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Growing prosthesis

Caitlin Martin, Wei Sun
Transcatheter aortic valve (TAV) implantation within a failed bioprosthetic valve is a growing trend for high-risk patients. The non-compliant stent of the previous prosthesis may prevent full expansion of the TAV, which has been shown to distort the leaflet configuration, and has been hypothesized to adversely affect durability. In this study, TAV leaflet fatigue damage under cyclic pressurization in the setting of stent underexpansion by 0 (fully expanded), 1, 2 and 3 mm was simulated using finite element analysis to test this hypothesis...
October 12, 2016: Annals of Biomedical Engineering
E Brauner, S Jamshir, G Guarino, A Ciolfi, V Valentini, G Pompa, S Di Carlo
OBJECTIVE: Although tumors of minor salivary glands are rare, the pleomorphic adenoma is the most common pathology among the benign neoplasm and can be found with high prevalence in the junction between hard palate and soft palate. Most of the maxillary tumors are surgically treated through either a total or partial maxillectomy. However, surgical defects lead to both clinical and psychologic disorders for the patient. A postoperative obturator prosthesis is a good option in patients who underwent maxillectomy...
September 2016: European Review for Medical and Pharmacological Sciences
Rachael W Quinn, Arthur A Bert, Gabriel L Converse, Eric E Buse, Stephen L Hilbert, William B Drake, Richard A Hopkins
BACKGROUND: Cardiac allometric organ growth after pediatric valve replacement can lead to patient-prosthesis size mismatch and valve re-replacement, which could be mitigated with allogeneic decellularized pulmonary valves treated with collagen conditioning solutions to enhance biological and mechanical performance, termed "bioengineered valves." In this study, we evaluated functional, dimensional, and biological responses of these bioengineered valves compared with traditional cryopreserved valves implanted in lambs during rapid somatic growth...
October 2016: Journal of Thoracic and Cardiovascular Surgery
Yan Qian, Xinwen Zhang, Linghai Xie, Dianpeng Qi, Bevita K Chandran, Xiaodong Chen, Wei Huang
Stretchable electronics are essential for the development of intensely packed collapsible and portable electronics, wearable electronics, epidermal and bioimplanted electronics, 3D surface compliable devices, bionics, prosthesis, and robotics. However, most stretchable devices are currently based on inorganic electronics, whose high cost of fabrication and limited processing area make it difficult to produce inexpensive, large-area devices. Therefore, organic stretchable electronics are highly attractive due to many advantages over their inorganic counterparts, such as their light weight, flexibility, low cost and large-area solution-processing, the reproducible semiconductor resources, and the easy tuning of their properties via molecular tailoring...
August 30, 2016: Advanced Materials
Joao S Soares, Kristen R Feaver, Will Zhang, David Kamensky, Ankush Aggarwal, Michael S Sacks
The use of replacement heart valves continues to grow due to the increased prevalence of valvular heart disease resulting from an ageing population. Since bioprosthetic heart valves (BHVs) continue to be the preferred replacement valve, there continues to be a strong need to develop better and more reliable BHVs through and improved the general understanding of BHV failure mechanisms. The major technological hurdle for the lifespan of the BHV implant continues to be the durability of the constituent leaflet biomaterials, which if improved can lead to substantial clinical impact...
August 9, 2016: Cardiovascular Engineering and Technology
L Renner, C Perka, A Trampuz, N Renz
The increasing number of prosthesis implantations and higher life expectancy lead to a growing number of periprosthetic infections (PPI). Optimal therapy necessitates interdisciplinary coordination of surgical and antimicrobial treatment. Challenges in the treatment are the increased occurrence of resistant pathogens, selection of adequate antimicrobial and surgical treatment strategies, inappropriate pretreatment and comorbidities of patients. Current treatment concepts lead to a high success rate in terms of infection eradication, when correctly applied...
October 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Francesco Nappi, Angelo Rosario Carotenuto, Arsenio Cutolo, Pierre Fouret, Christophe Acar, Juan Carlos Chachques, Massimiliano Fraldi
Synthetic grafts are often satisfactory employed in cardiac and vascular surgery, including expanded poly(ethylene terephthalate) or expanded poly(tetrafluoroethylene). However, accumulating evidences suggest the emergence of worrisome issues concerning the long-term fate of prosthetic grafts as large vessel replacement. Disadvantages related to the use of synthetic grafts can be traced in their inability of mimicking the elasto-mechanical characteristics of the native vascular tissue, local suture overstress leading to several prosthesis-related complications and retrograde deleterious effects on valve competence, cardiac function and perfusion...
October 2016: Journal of the Mechanical Behavior of Biomedical Materials
Muhammad Adil Abbas Khan, Ammar Asrar Javed, Dominic Jordan Rao, J Antony Corner, Peter Rosenfield
Pediatric traumatic limb amputations are rare and their acute and long term management can be challenging in this subgroup of patients. The lengthy and costly hospital stays, and resulting physical and psychological implications leads to significant morbidity. We present a summary of treatment principles and the evidence base supporting the management options for this entity. The initial management focuses on resuscitating and stabilization of the patients, administration of appropriate and adequate analgesics, and broad spectrum antibiotics...
January 2016: World Journal of Plastic Surgery
Tushar Kulkarni, Rashmi Uddanwadiker
Continuous growth in industrialization and lack of awareness in safety parameters the cases of amputations are growing. The search of safer, simpler and automated prosthetic arms for managing upper limbs is expected. Continuous efforts have been made to design and develop prosthetic arms ranging from simple harness actuated to automated mechanisms with various control options. However due the cost constraints, the automated prosthetic arms are still out of the reach of needy people. Recent data have shown that there is a wide scope to develop a low cost and light weight upper limb prosthesis...
September 2015: Molecular & Cellular Biomechanics: MCB
Ying Jiang, Yun-Kun Wang, Ming-Kun Yu
INTRODUCTION: The cranioplasty is a classical surgical procedure to repair large skull defects. The prosthesis fracture was one rare complication following cranioplasty, which was only known to happen in traumatic head injury or child growing skull. PRESENTATION OF CASE: In the current report, we documented the first reported case of cranioplasty prosthesis fracture in an adult neurological trauma patient at the proximal pterion point region without head trauma...
2016: International Journal of Surgery Case Reports
Da-cai Shang, Sheng-cai Zhong, Xiao-zhao Zhang, Deng-peng Lu, Qin-lin Liu
OBJECTIVE: To investigate the mothod and therapeutic efficacy of total hip anthroplasties (THA) for osteoarthritis secondary to Crowe type IV developmental dysplasia of hip in adults. METHODS: From May 2006 to December 2013, THA was performed on 15 adult patients (17 hips) with Growe type IV acetabular dysplasia, including 13 females and 2 males, with a mean age of 30.9 years old (22 to 58 years old) and an average preoperative Harris score of (34.0 ± 6.5) points...
February 2016: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Nelson Fernandes, Jacobus van den Heever, Christiaan Hoogendijk, Sarel Botha, Gerrie Booysen, Johan Els
Malignant peripheral nerve sheath tumors are extremely rare tumors arising in peripheral nerves. Only 17 cases involving the trigeminal nerve have ever been reported. These tumors have a very poor prognosis and very high rates of recurrence and metastases. Their recommended treatment involves complete tumor resection followed by radiation. This can be problematic in the head and neck region. We present a clinical case involving a 33-year-old female patient presenting with a slow-growing, exophytic mass of the anterior maxilla...
April 28, 2016: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
Fumiho Sano, Kazuhiro Ueda, Junichi Murakami, Masataro Hayashi, Arata Nishimoto, Kimikazu Hamano
BACKGROUND: Pneumonectomy induces active growth of the remaining lung in order to compensate for lost lung tissue. We hypothesized that tumor progression is enhanced in the activated local environment. METHODS: We examined the effects of mechanical strain on the activation of lung growth and tumor progression in mice. The mechanical strain imposed on the right lung after left pneumonectomy was neutralized by filling the empty space that remained after pneumonectomy with a polypropylene prosthesis...
May 1, 2016: Journal of Surgical Research
John M Stulak, Bassem N Mora, Sameh M Said, Hartzell V Schaff, Joseph A Dearani
Although most valve operations performed annually address lesions of the aortic or mitral valves, the frequency of pulmonary valve replacement (PVR) is increasing because most patients with congenital heart disease are surviving into the adult years. The vast majority of patients, especially children that require PVR, obtain a tissue valve because of the relative good durability and the lack of a need for anticoagulation. Because the need for repeat operation is inevitable for most patients, and the population of adults with congenital heart disease continues to grow, there are increasing situations in which a mechanical pulmonary prosthesis may be appropriate...
2016: Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual
John W Brown, Parth M Patel, Jiuann-Huey Ivy Lin, Asma S Habib, Mark D Rodefeld, Mark W Turrentine
BACKGROUND: The Ross aortic valve replacement (AVR) has been the AVR of choice for children at our center since 1993. Absence or inadequate quality of the pulmonary valve or, less commonly, family or surgeon preference caused us to select an alternative AVR prosthesis for some children. This review compares the outcomes of 42 children who received a non-Ross AVR with 115 children undergoing Ross root replacement at our institution during the most recent 22 years. METHODS: A retrospective chart review of the 42 pediatric non-Ross AVRs was compared with 115 Ross AVRs...
May 2016: Annals of Thoracic Surgery
Takashi Murakami, Yasuo Suehiro, Shinsuke Nishimura, Kenichi Sugioka, Shinichi Iwata, Asahiro Ito, Etsuji Sohgawa, Kazuki Mizutani, Minoru Yoshiyama, Toshihiko Shibata
Because paravalvular leak after mitral valve replacement in highly morbid patients is a troublesome issue, there has been a growing interest in less invasive procedures. We conducted transcatheter paravalvular leak closure of a mitral valve prosthesis through left ventricular apical access. The patient had undergone redo mitral valve replacement through a transatrial septal approach 2 months prior to the procedure; thus, penetration of the atrial septum was considered to be difficult through the ordinary antegrade trans-septal approach...
March 31, 2016: General Thoracic and Cardiovascular Surgery
Gerhard M Hobusch, Jakob Bollmann, Stephan E Puchner, Nikolaus W Lang, Jochen G Hofstaetter, Philipp T Funovics, Reinhard Windhager
BACKGROUND: Limited information is available about sports activities of survivors after resection and reconstruction of primary malignant bone tumors with megaprostheses. Because patients often ask what activities are possible after treatment, objective knowledge about sports activities is needed to help assess the risks of sports participation and to help guide patients' expectations. QUESTIONS/PURPOSES: The aims of this study were to evaluate (1) what proportion of patients with proximal-femoral megaprostheses placed as part of tumor reconstructions can perform sports; (2) what activity levels they achieved; and (3) whether sports activity levels are associated with an increased likelihood of revision...
March 28, 2016: Clinical Orthopaedics and related Research
Ferran Torner, Josep M Segur, Rosendo Ullot, Francisco Soldado, Pedro Domenech, Lydia DeSena, Jorge Knorr
PURPOSE: The non-invasive expandable prosthesis for skeletally immature patients is used after limb salvage surgery following tumor resection. The aim of the study was to assess the effectiveness of this treatment. METHODS: Seven paediatric patients with femoral tumors had resection and limb salvage with an uncemented non-invasive growing prosthesis. Mean age at the time of surgery was 9.8 (range 8-12) years. There were six distal femur osteosarcomas and one proximal femur Ewing sarcoma...
August 2016: International Orthopaedics
Jouha Min, Ki Young Choi, Erik C Dreaden, Robert F Padera, Richard D Braatz, Myron Spector, Paula T Hammond
Infections associated with orthopedic implants cause increased morbidity and significant healthcare cost. A prolonged and expensive two-stage procedure requiring two surgical steps and a 6-8 week period of joint immobilization exists as today's gold standard for the revision arthroplasty of an infected prosthesis. Because infection is much more common in implant replacement surgeries, these issues greatly impact long-term patient care for a continually growing part of the population. Here, we demonstrate that a single-stage revision using prostheses coated with self-assembled, hydrolytically degradable multilayers that sequentially deliver the antibiotic (gentamicin) and the osteoinductive growth factor (BMP-2) in a time-staggered manner enables both eradication of established biofilms and complete and rapid bone tissue repair around the implant in rats with induced osteomyelitis...
April 26, 2016: ACS Nano
Saverio Affatato, Saverio Comitini, Matteo Fosco, Aldo Toni, Domenico Tigani
INTRODUCTION: Since 1979 the number of patients treated with femoral stems has continued to grow, as well as the number of stems with features similar to the Zweymüller prosthesis produced by different companies. Identification can be problematic in case requiring revision. In the present paper, we present an overview of morphometric differences between the different stem designs, which can be useful for radiologic identification in revision cases. METHODS: By doing some research on the Internet of specialized sites and worldwide literature, we searched for all femoral stems agreeing with Zweymüller principles (cementless, straight, tapered, rectangular cross-sectioned femoral stems)...
February 29, 2016: International Orthopaedics
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