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Myxofibrosarcoma

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https://www.readbyqxmd.com/read/29785541/new-observations-in-tumor-cell-plasticity-mutational-profiling-in-a-case-of-metastatic-melanoma-with-biphasic-sarcomatoid-transdifferentiation
#1
Niels J Rupp, Markus Rechsteiner, Sandra N Freiberger, Daniela Lenggenhager, Mirjana Urosevic, Irene A Burger, Elisabeth J Rushing, Daniela Mihic-Probst
We describe a highly unusual case of metastatic melanoma in a 61-year-old female that manifested as a single groin lymph node metastasis accompanied by two distinct, subcutaneous sarcomatoid tumors on the same leg, without evidence of a primary tumor. Characterization encompassed extensive immunohistochemical staining as well as next-generation sequencing (NGS). The lymph node metastasis showed obvious features of melanoma. The two subcutaneous lesions, however, were morphologically and immunohistochemically consistent with high-grade myxofibrosarcoma and soft tissue mixed tumor, respectively...
May 21, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29748938/an-entire-clinical-course-of-mediastinal-myxofibrosarcoma-treated-by-surgery-and-radiation
#2
Yasoo Sugiura, Hiroyuki Fujimoto, Toshinori Hashizume, Go Ogura, Etsuo Nemoto
A woman in her 70s with an 8.6-cm tumor in the anterior mediastinum underwent tumor excision by median sternotomy, which combined resection of the fifth and sixth ribs. The pathological diagnosis was myxofibrosarcoma, and pathologically curative resection was accomplished. Local recurrence was detected at 10, 19, 23 and 28 months after the initial surgery. After repeated surgical resection, radiation therapy for the fourth unresectable recurrence resulted in failure. She died 34 months after the initial surgery...
May 10, 2018: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29720127/primary-cardiac-myxofibrosarcoma-case-report-literature-review-and-pooled-analysis
#3
Dandan Sun, Yupeng Wu, Yan Liu, Jun Yang
BACKGROUND: Primary cardiac myxofibrosarcoma is a very rare cardiac malignancy. The majority of publications are limited to case reports. No pooled analyses of primary cardiac myxofibrosarcoma cases are available. Little clinical features and outcome patterns are acknowledged. The purpose of this study is to identify the clinical characteristics and prognostic factors of primary cardiac myxofibrosarcoma. CASE PRESENTATION: A case report of primary cardiac myxofibrosarcoma was presented, and a review of English language literatures of primary cardiac myxofibrosarcomas were performed electronically...
May 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29702311/initial-experience-with-intraoperative-phosphorous-32-brachytherapy-during-resection-of-malignant-spinal-tumors
#4
Cecilia L Dalle Ore, Christopher P Ames, Stephen T Magill, Vedat Deviren, Manish K Aghi, Darryl Lau
INTRODUCTION: Brachytherapy is a major adjuvant modality for neoplasms, but few have trialed its use for spinal tumors. This study examines perioperative and oncological outcomes of malignant spinal tumor patients who underwent resection with intraoperative phosphorous-32 (P32) brachytherapy. METHODS: Consecutive adult patients who underwent P32 brachytherapy during malignant spinal tumor resection were retrospectively identified from 2014 to 2015. Complications, tumor recurrence, and survival were reviewed...
April 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29659611/preoperative-evaluation-of-the-efficacy-of-radio-hyperthermo-chemotherapy-for-soft-tissue-sarcoma-in-a-case-series
#5
Hisaki Aiba, Satoshi Yamada, Jun Mizutani, Norio Yamamoto, Hideki Okamoto, Katsuhiro Hayashi, Hiroaki Kimura, Akihiko Takeuchi, Shinji Miwa, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Yoshihiro Araki, Hiroyuki Tsuchiya, Takanobu Otsuka
PURPOSE: Radio-hyperthermo-chemo (RHC) therapy, which combines radiotherapy, hyperthermia, and chemotherapy, for malignant soft tissue tumors has been introduced with the aim of decreasing the possibility of local recurrence after surgery. To avoid unnecessary neoadjuvant therapy and to plan the appropriate surgical treatment, surveillance of RHC therapeutic efficacy during treatment is necessary. In this study, we determined the optimal response criteria to evaluate the efficacy of RHC by comparing preoperative images before and after RHC with pathological evaluation of necrosis in the resected tumor...
2018: PloS One
https://www.readbyqxmd.com/read/29649644/endoscopic-transseptal-approach-with-a-bilateral-nasoseptal-flap-in-challenging-skull-base-tumors
#6
Do Hyun Kim, Yong-Kil Hong, Sin-Soo Jeun, Jae-Sung Park, Soo Whan Kim, Jin Hee Cho, Yong Jin Park, Sung Won Kim
OBJECTIVE: To examine the utility of an endoscopic transseptal approach and the creation of a bilateral nasoseptal flap using a two-nostrils/four-hands technique in patients with challenging skull-base tumors. METHODS: The medical records of patients operated on via an endoscopic transseptal approach between 2009 and 2017 were retrospectively reviewed. Two patients with ossifying fibroma, two with orbital hemangioma, two with trigeminal nerve schwannoma, and one patient each with juvenile angiofibroma, meningioma, and myxofibrosarcoma were included in the study...
April 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29610117/cd163-is-required-for-protumoral-activation-of-macrophages-in-human-and-murine-sarcoma
#7
Daisuke Shiraishi, Yukio Fujiwara, Hasita Horlad, Yoichi Saito, Toyohisa Iriki, Junko Tsuboki, Pan Cheng, Naomi Nakagata, Hiroshi Mizuta, Hirofumi Bekki, Yasuharu Nakashima, Yoshinao Oda, Motohiro Takeya, Yoshihiro Komohara
Recent findings have shown the significance of CD163-positive macrophages in tumor progression, yet there have been few studies on the function of CD163 in macrophages. Here we uncover the role of CD163 in macrophage activation using CD163-deficient mice and human samples. We detected CD163 in 62 undifferentiated pleomorphic sarcoma samples, in which a high percentage of CD163-positive macrophages was associated with decreased overall survival and higher histological grade. We observed macrophage-induced tumor cell proliferation in co-cultures of human monocyte-derived macrophages and leiomyosarcoma (TYLMS-1) and myxofibrosarcoma (NMFH-1) cell lines, which was abrogated by silencing of CD163...
April 2, 2018: Cancer Research
https://www.readbyqxmd.com/read/29555080/non-islet-cell-tumour-hypoglycaemia-nicth-about-a-series-of-6-cases
#8
Arnaud Jannin, Stéphanie Espiard, Kanza Benomar, Christine Do Cao, Bénédicte Mycinski, Henri Porte, Michèle D'Herbomez, Nicolas Penel, Marie-Christine Vantyghem
The purpose of this study was to analyse the characteristics of 6 patients managed in a university hospital between 1996 and 2016 for non-islet cell tumor hypoglycemia (NICTH), a form of hypoglycaemia due to the paraneoplastic secretion of IGF-2 or its related substances. RESULTS: Three of these 6 patients (50%), aged over 69 years, including 2 with acromegaloid phenotype, presented with a pleural solitary fibrous tumor (SFT), with median diameter 20 cm (interquartile range, 12.5-20.5) with a low median SUV (3...
March 16, 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29449896/myxofibrosarcoma-primary-cultures-molecular-and-pharmacological-profile
#9
Alessandro De Vita, Federica Recine, Laura Mercatali, Giacomo Miserocchi, Chiara Liverani, Chiara Spadazzi, Roberto Casadei, Alberto Bongiovanni, Federica Pieri, Nada Riva, Dino Amadori, Toni Ibrahim
Background: Myxofibrosarcoma (MFS), formerly considered as a myxoid variant of malignant fibrous histiocytoma, is the most common sarcoma of the extremities in adults and is characterized by a high frequency of local recurrence. The clinical behavior of MFS is unpredictable and the efficacy of chemotherapy is still not well documented. Furthermore, given the relatively recent recognition of MFS as a distinct pathologic entity its cellular and molecular biology has still not been extensively studied in patient-derived preclinical models...
December 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29414432/clinicopathologic-features-and-outcomes-of-primary-cardiac-tumors-a-16-year-experience-with-212-patients-at-a-chinese-medical-center
#10
Ji-Gang Wang, Baolei Wang, Yanjiao Hu, Ji-Hua Liu, Bing Liu, Hui Liu, Peng Zhao, Lijuan Zhang, Yu-Jun Li
Primary cardiac tumors are uncommon, and the majority of them are benign which are curable but can cause significant morbidity if not diagnosed and treated in a timely fashion. The objective of this study was to review the clinicopathologic features and surgical outcomes of patients with primary cardiac tumors in a single medical center in China. We have retrospectively reviewed 212 consecutive adult patients who underwent surgical resection of primary cardiac tumors at our center from January of 2001 to June of 2017...
March 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29409129/successful-management-of-a-rare-type-of-complex-myxofibrosarcoma-which-affected-right-lung-and-invading-into-the-left-atrium-under-the-guidance-of-multimode-image
#11
Heng Zhang, Da Zhu, Li Dong
Myxofibrosarcoma is a rare type of highly malignant sarcoma which easily occur lung metastasis. We report a rare metastatic myxofibrosarcoma which generated from the upper and middle lobe of the lung, invading the right superior pulmonary vein, extending to the left atrium. A single imaging examination may lead to misdiagnosis, so the combination of computed tomography imaging, magnetic resonance imaging, as well as positron emission tomographic scan are necessary for perioperative diagnosis and surgical planning...
February 2018: Echocardiography
https://www.readbyqxmd.com/read/29375952/primary-cardiac-high-grade-myxofibrosarcoma-presenting-with-multiple-brain-metastases-a-case-report
#12
Filippo Badaloni, Eugenio Pozzati, Gianluca Marucci, Pietro Fiaschi, Antonio Fioravanti
Herein we describe the case of a young patient who presented with a recent history of epilepsy due to multiple brain lesions; he did not complain about any cardiopulmonary impairments. The patient died as a consequence of hemorrhagic progression of brain metastatic disease. Regardless of a thorough investigation, the heart tumor remained occult. Primary cardiac tumors are very rare entities. Most of these are benign, but approximately 25% are malignant, and the majority of these are sarcomas. Myxofibrosarcoma and osteosarcoma are exceptionally rare...
November 21, 2017: Curēus
https://www.readbyqxmd.com/read/29361819/pembrolizumab-for-refractory-metastatic-myxofibrosarcoma-a-case-report
#13
Haa-Na Song, Min Gyu Kang, Jeong Rang Park, Jin-Yong Hwang, Jung Hun Kang, Won Seop Lee, Gyeong-Won Lee
Myxofibrosarcoma is a rare tumor, refractory to cytotoxic chemotherapy and radiotherapy. Pembrolizumab is an innovative immunotherapy drug consisting of programmed death ligand receptor-1 (PD-L1) antibody proven to be useful for numerous types of cancer cells. A patient had been diagnosed with metastatic myxofibrosarcoma, refractory to radiotherapy and conventional cytotoxic chemotherapy. The patient achieved a partial response during palliative chemotherapy with pembrolizumab for 14 cycles. To the best of our knowledge, this is the first case report demonstrating the efficacy of pembrolizumab for refractory myxofibrosarcoma...
January 22, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29355158/histological-types-of-soft-tissue-sarcomas-at-the-lagos-university-teaching-hospital
#14
Nzechukwu Zimudo Ikeri, Andrea Oludolapo Akinjo, Olugbende O Ajayi, Adekunbiola Aina Fehintola Banjo
OBJECTIVE: There is scanty data on histologically diagnosed soft-tissue sarcomas in the Nigerian literature. This is due to paucity of facilities for ancillary testing as well as a dearth of specialist soft tissue pathologists. Knowledge however of the common soft-tissue sarcomas is vital for the establishment of an effective sarcoma service. The aim of this study, therefore, was to determine the histological spectrum of soft-tissue sarcomas in Lagos, Nigeria. MATERIALS AND METHODS: Archival haematoxylin and eosin (H and E)-stained slides were retrieved and reviewed by a team of soft-tissue pathologists at the Royal National Orthopaedic Hospital, London, UK...
October 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29312771/low-grade-myxofibrosarcoma-in-the-right-ventricle-presenting-as-pulmonary-thromboembolism
#15
Jong Hui Suh, Do Yeon Kim, Jeong Seob Yoon, Eun Su Park, Chan Beom Park
We report an unusual malignant cardiac neoplasm that initially presented as pulmonary thromboembolism in a 78-year-old male. Despite anticoagulation, the pulmonary artery lesion progressed and a mass-like lesion developed in the right ventricular outflow tract. Venoarterial extracorporeal membrane oxygenation was applied before surgery due to the presence of severe right-side heart failure with pulmonary hypertension. A round mass was found in the right ventricle and separate lobulated masses were found in both pulmonary arteries, and these were consistent with low-grade myxofibrosarcoma...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29280521/left-atrial-appendage-myxofibrosarcoma-a-rare-masquerader-of-myxoma-and-thrombus-all-that-glitters-is-not-gold
#16
Muhammad Shoaib Khan, Sahadev Reddy, Richard Lombardi, Pitti Isabel, Walter E Mcgregor, Bang Tang, George Gabriel, Robert W Biederman
Left atrial appendage mass can occasionally pose a serious challenge to physicians to identify the nature of the mass with the aid of imaging techniques. We present a case of 67-year-old man, who was evaluated for suspected left atria myxoma. Transesophageal echocardiography revealed a heterogeneous density originating from left atrial appendage, thought to be most consistent with a myxoma. Cardiac magnetic resonance imaging, uncharacteristically, gave an equivocal picture, suggesting the mass to be a myxoma on initial imaging and a thrombus with evidence of liquefaction necrosis following postcontrast enhancement...
February 2018: Echocardiography
https://www.readbyqxmd.com/read/29220302/biology-and-management-of-undifferentiated-pleomorphic-sarcoma-myxofibrosarcoma-and-malignant-peripheral-nerve-sheath-tumors-state-of-the-art-and-perspectives
#17
Brigitte C Widemann, Antoine Italiano
Undifferentiated pleomorphic sarcomas, myxofibrosarcomas, and malignant peripheral nerve sheath tumors are characterized by complex genomic characteristics and aggressive clinical behavior. Recent advances in the understanding of the pathogenesis of these tumors may allow for the development of more-effective innovative therapeutic strategies, including immunotherapies. This review describes the current knowledge of the epidemiology, clinical presentation, treatment, and pathogenesis of these tumors and highlights ongoing and future research...
January 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29065228/myxofibrosarcoma-of-unusual-sites
#18
B Joel Tjarks, Jennifer S Ko, Steven D Billings
BACKGROUND: Myxofibrosarcoma classically presents as a painless mass in the proximal extremities. Cutaneous myxofibrosarcomas arising in the head and neck and distal extremities are extremely uncommon. We present a series of 6 cases of myxofibrosarcoma presenting in the head and neck and acral locations. METHODS: Archives were searched using the term "myxofibrosarcoma" over a 6-year period (2009-2015). The clinicopathologic features of myxofibrosarcoma were recorded...
February 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29028101/topbp1-promotes-malignant-progression-and-correlates-with-poor-prognosis-in-osteosarcoma
#19
D-P Wu, X-B Yan, L-G Liu, C Tian, K Han, H Zhang, D-L Min
OBJECTIVE: Topoisomerase IIβ binding protein 1 (TopBP1) is involved in DNA damage and replication checkpoint and has been shown to be related to tumorigenesis in many cancer types. This study aimed to evaluate the biological role and clinicopathological significance of TopBP1 in OS. PATIENTS AND METHODS: TopBP1 expression in sarcoma patients was determined through the Oncomine database, and the prognostic role of TopBP1 expression was assessed in a retrospective cohort study...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28893544/myxofibrosarcoma-in-head-and-neck-case-report-of-unusually-aggressive-presentation
#20
Anastasiya Quimby, Abigail Estelle, Arun Gopinath, Rui Fernandes
Myxofibrosarcoma (MFS) is a malignant fibroblastic tumor that primarily affects the lower and upper extremities. It is usually described as a slow-growing tumor with high recurrence rates but low metastatic potential. The reported incidence of head and neck MFS is 2 to 4% and rarely presents with distant metastases. This report describes a case of maxillary MFS in a 72-year-old woman whose disease progression followed an atypical course with an extremely rapid rate of growth and early pulmonary and central nervous system lesions...
December 2017: Journal of Oral and Maxillofacial Surgery
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