keyword
MENU ▼
Read by QxMD icon Read
search

Myxofibrosarcoma

keyword
https://www.readbyqxmd.com/read/27909132/myxofibrosarcoma-of-the-extremity-and-trunk-a-multidisciplinary-approach-leads-to-good-local-rates-of-local-control
#1
C G Ghazala, N R Agni, M Ragbir, P Dildey, D Lee, K S Rankin, T B Beckingsale, C H Gerrand
AIMS: Myxofibrosarcomas (MFSs) are malignant soft-tissue sarcomas characteristically presenting as painless slowly growing masses in the extremities. Locally infiltrative growth means that the risk of local recurrence is high. We reviewed our experience to make recommendations about resection strategies and the role of the multidisciplinary team in the management of these tumours. PATIENTS AND METHODS: Patients with a primary or recurrent MFS who were treated surgically in our unit between 1997 and 2012 were included in the study...
December 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27879142/-myxofibrosarcoma-in-the-abdominal-cavity
#2
F Janů
A number of benign and malignant tumors may develop in the abdominal cavity. Sarcomas are rather rare tumors of the abdominal cavity. They are often diagnosed at advanced growth stages as their local growth can cause clinical problems to the patients. The author presents a case report of myxofibrosarcoma in the abdominal cavity.Key words: myxofibrosarcoma.
2016: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/27873216/prognostic-metabolite-biomarkers-for-soft-tissue-sarcomas-discovered-by-mass-spectrometry-imaging
#3
Sha Lou, Benjamin Balluff, Arjen H G Cleven, Judith V M G Bovée, Liam A McDonnell
Metabolites can be an important read-out of disease. The identification and validation of biomarkers in the cancer metabolome that can stratify high-risk patients is one of the main current research aspects. Mass spectrometry has become the technique of choice for metabolomics studies, and mass spectrometry imaging (MSI) enables their visualization in patient tissues. In this study, we used MSI to identify prognostic metabolite biomarkers in high grade sarcomas; 33 high grade sarcoma patients, comprising osteosarcoma, leiomyosarcoma, myxofibrosarcoma, and undifferentiated pleomorphic sarcoma were analyzed...
November 21, 2016: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/27858546/massively-distended-abdomen-caused-by-fibromatosis-previously-misdiagnosed-as-myxofibrosarcoma
#4
Michaela Kuhlen, Prasad T Oommen, Arndt Borkhardt
No abstract text is available yet for this article.
November 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/27832806/diagnosis-of-extraskeletal-myxoid-chondrosarcoma-in-the-thigh-using-ewsr1-nr4a3-gene-fusion-a-case-report
#5
Hiroki Kobayashi, Kazutaka Kikuta, Tetsuya Sekita, Michiro Susa, Kazumasa Nishimoto, Aya Sasaki, Kaori Kameyama, Shintaro Sugita, Tadashi Hasegawa, Masaya Nakamura, Morio Matsumoto, Hideo Morioka
BACKGROUND: Extraskeletal myxoid chondrosarcoma is a rare soft tissue sarcoma that has unusual ultrastructural and molecular features. However, unlike other soft tissue sarcomas, it does not have specific clinical symptoms or radiological features, which can make its diagnosis difficult. Nevertheless, extraskeletal myxoid chondrosarcoma has a rare gene fusion (EWSR1-NR4A3) that is useful for making a differential diagnosis. CASE PRESENTATION: A 43-year-old Japanese man presented with a soft tissue mass in his right thigh...
November 10, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27737652/ct-guided-cryoablation-for-locally-recurrent-or-metastatic-bone-and-soft-tissue-tumor-initial-experience
#6
Michiro Susa, Kazutaka Kikuta, Robert Nakayama, Kazumasa Nishimoto, Keisuke Horiuchi, Sota Oguro, Masanori Inoue, Hideki Yashiro, Seishi Nakatsuka, Masaya Nakamura, Morio Matsumoto, Kazuhiro Chiba, Hideo Morioka
BACKGROUND: Historically, local control of recurrent sarcomas has been limited to radiotherapy when surgical re-resection is not feasible. For metastatic carcinomas to the bone or soft tissue, radiotherapy and some interventional radiology treatment along with other systemic therapies have been widely advocated due to the possibility of disseminated disease. These techniques are effective in alleviating pain and achieving local control for some tumor types, but it has not been effective for prolonged local control of most tumors...
October 13, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27733900/high-nuclear-expression-of-proteasome-activator-complex-subunit-1-predicts-poor-survival-in-soft-tissue-leiomyosarcomas
#7
Sha Lou, Arjen H G Cleven, Benjamin Balluff, Marieke de Graaff, Marie Kostine, Inge Briaire-de Bruijn, Liam A McDonnell, Judith V M G Bovée
BACKGROUND: Previous studies on high grade sarcomas using mass spectrometry imaging showed proteasome activator complex subunit 1 (PSME1) to be associated with poor survival in soft tissue sarcoma patients. PSME1 is involved in immunoproteasome assembly for generating tumor antigens presented by MHC class I molecules. In this study, we aimed to validate PSME1 as a prognostic biomarker in an independent and larger series of soft tissue sarcomas by immunohistochemistry. METHODS: Tissue microarrays containing leiomyosarcomas (n = 34), myxofibrosarcomas (n = 14), undifferentiated pleomorphic sarcomas (n = 15), undifferentiated spindle cell sarcomas (n = 4), pleomorphic liposarcomas (n = 4), pleomorphic rhabdomyosarcomas (n = 2), and uterine leiomyomas (n = 7) were analyzed for protein expression of PSME1 using immunohistochemistry...
2016: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/27639272/lhrh-receptor-expression-in-sarcomas-of-bone-and-soft-tissue
#8
Chenthuran Deivaraju, H Thomas Temple, Norman Block, Philip Robinson, Andrew V Schally
AIM: Luteinizing hormone releasing hormone (LHRH) is a neurohormone, secreted by the hypothalamus, which regulates the secretion of gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the pituitary. LHRH acts by binding to receptors located in the pituitary gland. These receptors (LHRH receptors) have also been found in the cytoplasm of many tumor cells that involve both the reproductive and non-reproductive organs. These receptors have been demonstrated in prostate and breast cancers, endometrial carcinomas, renal cell carcinoma, lymphoma, carcinoma of liver, pancreas and skin...
November 1, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27617600/myxofibrosarcoma-presenting-as-an-exophytic-multi-lobed-nodule-on-the-leg
#9
Colton Nielson, Amy Schutte, Morgan L Wilson, Stephen P Stone
Myxofibrosarcoma may present as a dermal or subcutaneous nodule, often on the extremity of an elderly patient. We present a case of myxofibrosarcoma on the lower leg of a 77-year-old man, which illustrates the deeply infiltrative growth pattern of these tumors, as well as the potential for superficial biopsies to show lower grade histopathologic features than subsequent excision specimens.
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27594370/primary-cardiac-myxofibrosarcoma-in-a-young-woman
#10
V M Becerra-Muñoz, L Jordán-Martínez, E Gallego-Domínguez, M J Mataró-López, E Rodríguez-Caulo
No abstract text is available yet for this article.
August 2016: Acta Cardiologica
https://www.readbyqxmd.com/read/27591498/myxofibrosarcoma
#11
REVIEW
Christina L Roland, Wei-Lien Wang, Alexander J Lazar, Keila E Torres
Myxofibrosarcoma is a unique subtype of soft tissue sarcoma with a locally infiltrative behavior. High-quality MRI imaging is critical for preoperative planning. Wide surgical resection with a 2 cm soft tissue margin is the mainstay of treatment and can require complex vascular and plastic surgery reconstruction. Local recurrence is common, and a subset of patients with higher-grade lesions will develop distant metastases. Radiation may be beneficial in reducing local recurrence.
October 2016: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/27577794/integrin-%C3%AE-10-dependency-identifies-rac-and-rictor-as-therapeutic-targets-in-high-grade-myxofibrosarcoma
#12
Tomoyo Okada, Ann Y Lee, Li-Xuan Qin, Narasimhan Agaram, Takahiro Mimae, Yawei Shen, Rachael O'Connor, Miguel A López-Lago, Amanda Craig, Martin L Miller, Phaedra Agius, Evan Molinelli, Nicholas D Socci, Aimee M Crago, Fumi Shima, Chris Sander, Samuel Singer
: Myxofibrosarcoma is a common mesenchymal malignancy with complex genomics and heterogeneous clinical outcomes. Through gene-expression profiling of 64 primary high-grade myxofibrosarcomas, we defined an expression signature associated with clinical outcome. The gene most significantly associated with disease-specific death and distant metastasis was ITGA10 (integrin-α10). Functional studies revealed that myxofibrosarcoma cells strongly depended on integrin-α10, whereas normal mesenchymal cells did not...
October 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27560552/establishment-and-molecular-characterisation-of-seven-novel-soft-tissue-sarcoma-cell-lines
#13
Abdulazeez Salawu, Malee Fernando, David Hughes, Malcolm W R Reed, Penella Woll, Claire Greaves, Chris Day, Meshal Alhajimohammed, Karen Sisley
BACKGROUND: Soft-tissue sarcomas (STS) are a diverse group of malignancies that remain a diagnostic and therapeutic challenge. Relatively few reliable cell lines currently exist. Rapidly developing technology for genomic profiling with emerging insights into candidate functional (driver) aberrations raises the need for more models for in vitro functional validation of molecular targets. METHODS: Primary cell culture was performed on STS tumours utilising a differential attachment approach...
October 25, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27546198/myxofibrosarcoma-of-the-heart-a-case-report-with-positive-pleural-effusion-cytology
#14
Yoko Hagiwara, Kayoko Nakamura, Masako Taguchi, Ayaka Ashiwa, Chieko Nishioka, Takashi Kono, Naomi Matsuzaki, Yoshiaki Yuba
Primary cardiac sarcoma is rare, and there have been only a few reports on its cytologic findings. Myxofibrosarcoma, a variant of fibrosarcoma of the heart, is an extremely rare entity. We present a case of primary cardiac myxofibrosarcoma in a 63-year-old woman. Pleural fluid cytology and imprint cytology of the resected tumor at operation and autopsy were obtained. Cytologic evaluation with immunocytochemical staining utilizing a cell transfer technique revealed that tumor cells of the resected tumor and autopsy specimen and pleural effusion demonstrated large and pleomorphic cells with irregular, hyperchromatic nuclei and were positive for vimentin...
December 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27523716/an-unexpected-skin-ulcer-and-soft-tissue-necrosis-after-the-nonconcurrent-combination-of-proton-beam-therapy-and-pazopanib-a-case-of-myxofibrosarcoma
#15
Nobuhiro Uwa, Tomonori Terada, Takeshi Mohri, Yoshitane Tsukamoto, Hiroyuki Futani, Yusuke Demizu, Tomoaki Okimoto, Masafumi Sakagami
We herein report the case of a patient presenting with myxofibrosarcoma (MFS) who underwent treatment with surgery, proton beam therapy (PBT), and pazopanib. A 64-year-old male was diagnosed with MFS, which ranged from the posterior neck to the shoulder. Surgery was performed as an initial treatment; however, the primary tumor recurred 83 months after the initial treatment. We, therefore, administered PBT. Although most of the recurrent tumor disappeared after PBT, multiple lung metastases were identified 3 months after the completion of PBT...
August 11, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27505448/myxofibrosarcoma-in-the-thenar-eminence
#16
James Martin-Smith, Niall McInerney, Christina Buckley, Jennifer Gilmore, Edward Jason Kelly
Myxofibrosarcoma is a rare cause of swelling in the upper extremities. The rarer form arising in the deep tissues can present a diagnostic difficulty. The treatment of high-grade myxofibrosarcoma in the extremity requires tissue diagnosis, accurate staging, careful multidisciplinary agreement on treatment, accurate execution of that treatment, and finally regular specialist surveillance. The treatment must be planned on an individual basis, weighing the risk of distant metastasis against the potential for severe functional impairment should radical excision or amputation be performed...
August 8, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27503444/patterns-of-disease-relapse-in-primary-extremity-soft-tissue-sarcoma
#17
H G Smith, N Memos, J M Thomas, M J F Smith, D C Strauss, A J Hayes
BACKGROUND: Extremity soft-tissue sarcomas comprise a range of distinct histological subtypes. This study aimed to characterize the patterns of disease relapse in patients undergoing resection of primary extremity soft-tissue sarcoma. METHODS: All patients who had resection of primary extremity soft-tissue sarcoma at the Royal Marsden Hospital between January 2004 and January 2014 were identified from an institutional database. RESULTS: In the period examined, 556 patients underwent resection...
October 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27501198/modified-partial-maxillary-swing-approach-for-myxofibrosarcoma-in-pterygopalatine-fossa
#18
Hikari Shimoda, Koichiro Yonezawa, Hirotaka Shinomiya, Naoki Otsuki, Kazunobu Hashikawa, Ryohei Sasaki, Eiji Komura, Ken-Ichi Nibu
BACKGROUND: Extirpation of tumors arising in the pterygopalatine fossa is challenging because of its anatomic complexity. METHODS AND RESULTS: A 67-year-old man was referred to our department with a diagnosis of a tumor in his left pterygoid fossa. An incisional biopsy through the canine fossa was diagnosed as myxofibrosarcoma. The upper part of the maxilla was swung laterally to remove the tumor while the hard plate was preserved. The defect was reconstructed using rectus abdominis musculocutaneous free and ipsilateral temporal...
December 2016: Head & Neck
https://www.readbyqxmd.com/read/27491785/primary-extremity-soft-tissue-sarcomas-does-local-control-impact-survival
#19
Sylvie Bonvalot, Antonin Levy, Philippe Terrier, Dimitri Tzanis, Sara Bellefqih, Axel Le Cesne, Cécile Le Péchoux
BACKGROUND: The objective of this study was to evaluate the adequate margin in the local treatment of extremity soft tissue sarcomas (ESTS) and understand the relationship between local control and overall survival (OS). METHODS: All consecutive patients treated for a primary ESTS at a single center from 1993 to 2012 were reviewed. RESULTS: In all, 531 patients were included. Twelve (2 %) underwent a first-line amputation. The resections were R0/R1/not available in 434 (82 %), 92 (17 %), and 5 patients (1 %)...
August 4, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27387491/a-case-report-of-primary-cardiac-myxofibrosarcoma-presenting-with-severe-congestive-heart-failure
#20
Kosuke Ujihira, Akira Yamada, Naritomo Nishioka, Yutaka Iba, Ryushi Maruyama, Katsuhiko Nakanishi, Ai Shimizu, Kanako C Hatanaka, Tomoko Mitsuhashi, Toshiya Shinohara, Hatsue Ishibashi Ueda
BACKGROUND: Primary cardiac sarcomas are extremely rare. Furthermore, the myxofibrosarcomas are one of the rarest forms of cardiac sarcomas, and its prognosis is known to be quite poor. CASE PRESENTATION: This is a case of a 23-year-old man who presented with acute severe congestive heart failure caused by almost complete obstruction of the mitral valve due to a large left atrial tumor. The patient required endotracheal intubation before his arrival to the hospital, and underwent an emergent surgical excision of the tumor...
2016: Journal of Cardiothoracic Surgery
keyword
keyword
81657
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"