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Fibrosarcoma

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https://www.readbyqxmd.com/read/29683818/pan-trk-immunohistochemistry-identifies-ntrk-rearrangements-in-pediatric-mesenchymal-tumors
#1
Erin R Rudzinski, Christina M Lockwood, Bradley A Stohr, Sara O Vargas, Rachel Sheridan, Jennifer O Black, Veena Rajaram, Theodore W Laetsch, Jessica L Davis
Activating neurotrophic receptor kinase (NTRK) fusions define certain pediatric mesenchymal tumors, including infantile fibrosarcoma and cellular mesoblastic nephroma. Traditionally, molecular confirmation of these fusions has included either fluorescent in situ hybridization for ETV6 rearrangements or reverse-transcriptase polymerase chain reaction for the classic ETV6-NTRK3 fusion. However, these methods overlook variant NTRK rearrangements, which are increasingly appreciated as recurrent events in a subset of pediatric mesenchymal tumors...
April 20, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29658958/treatment-with-src-inhibitor-dasatinib-results-in-elevated-metastatic-potential-in-the-4t1-murine-mammary-carcinoma-model
#2
Veronica S Hughes, Dietmar W Siemann
Introduction: The src inhibitor Dasatinib has been widely studied as an anti-metastatic agent. The aims of this study were to examine the effect of Src inhibition on the metastatic potential of the 4T1 murine mammary carcinoma. Context: Src is a non-receptor tyrosine kinase well-known to contribute to the metastatic potential of tumour cells. It does so through alteration of signalling pathways important to metastasis. Elevated levels of Src are common in many cancer types, and have been correlated with tumour progression and poor patient prognosis...
2018: Tumor & microenvironment
https://www.readbyqxmd.com/read/29658783/fibrosarcoma-arising-in-the-paranasal-sinus-a-clinicopathological-and-radiological-analysis
#3
Junjie Zeng, Huaping Liu, Lizhi Liu, Weihua Liao, Ping Hu, Xiaoyi Wang, Xuejun Li, Lunquan Sun, Youming Zhang, Xiaoping Yi
OBJECTIVES: To analyze the clinicopathological features and the CT and MRI features of patients with paranasal sinus fibrosarcoma. METHODS: Seven patients with surgically and pathologically confirmed paranasal sinus fibrosarcoma were enrolled. Their CT and MRI data and imaging features were retrospectively analyzed in detail. RESULTS: The study participants were two males and five females (median age, 43 years; range, 22-73 years). CT or MRI imaging showed a well-defined (n = 5) or ill-defined (n = 2), irregular (n = 6) or oval (n = 1) mass, with heterogeneous (n = 7) density...
April 16, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29658114/proton-pump-inhibitor-use-and-cancer-mortality
#4
Siri A Tvingsholm, Christian Dehlendorff, Kell Østerlind, Søren Friis, Marja Jäättelä
Proton pump inhibitors (PPIs) are commonly used as a supplement to cancer therapy. Yet, their effect on cancer mortality is largely unknown. Using data from Danish nationwide registries and Cox models regressing of both propensity scores and drug use, we estimated hazard ratios with 95% confidence intervals (CIs) for cancer-specific and non-cancer death among PPI users (≥2 prescriptions within six months after diagnosis; n=36,066) compared with nonusers (<2 prescriptions, n=311,853) or users of histamine H2 -receptor antagonists (H2 RA; n=5,152)...
April 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29630153/successful-management-of-congenital-infantile-fibrosarcoma-presenting-as-large-non-healing-buttock-ulceration
#5
Madeleine G Sowash, Karen Itumeleng Mosojane, Alan R Anderson, Carrie L Kovari, Victoria L Williams
A two-year-old boy presented with a large, non-healing ulceration on his left buttock, which was originally noted as a brown patch present at birth. Punch skin biopsy was performed and histopathology revealed an atypical, pleomorphic, spindled proliferation in whorled fascicles replacing the dermis and trapping fat in the subcutis, consistent with a diagnosis of congenital/infantile fibrosarcoma. No evidence of metastatic spread was seen on imaging. The tumor was initially deemed unresectable owing to extent of local invasion...
February 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29615178/unusual-presentation-of-fibrosarcoma-in-a-child
#6
Afshan Fayyaz, Chaudhry Aqeel Safdar
Malignant soft tissue tumours are rare in infants. Specific radiologic features help differentiate benign from malignant musculoskeletal entities. We report a case of malignant soft tissue tumour with initial radiologic evaluation suggesting a benign entity, thus delaying diagnosis. The case was treated as a case of cystic hygroma, suggested by ultrasound and MRI with good initial response to bleomycin injection. Later, symptoms recurred with poor response to repeat therapy which led to review the diagnosis...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29609122/microwave-assisted-one-pot-synthesis-of-new-phenanthrene-fused-tetrahydrodibenzo-acridinones-as-potential-cytotoxic-and-apoptosis-inducing-agents
#7
Niggula Praveen Kumar, Pankaj Sharma, T Srinivasa Reddy, Nagula Shankaraiah, Suresh K Bhargava, Ahmed Kamal
An expeditious microwave-assisted one-pot synthesis of new cytotoxic phenanthrene fused-tetrahydrodibenzo-acridinones has been successfully accomplished. This protocol offers wide substrate scope, catalyst-free synthesis, atom-economy, simple recrystallization, high yields, and ethanol was used as green solvent. These new compounds were tested for their in vitro cytotoxicity against cervical (HeLa), prostate (PC-3), fibrosarcoma (HT-1080), ovarian (SKOV-3) cancer cells, and were safer to normal (Hek-293T) kidney cell line...
March 27, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29606586/larotrectinib-for-paediatric-solid-tumours-harbouring-ntrk-gene-fusions-phase-1-results-from-a-multicentre-open-label-phase-1-2-study
#8
Theodore W Laetsch, Steven G DuBois, Leo Mascarenhas, Brian Turpin, Noah Federman, Catherine M Albert, Ramamoorthy Nagasubramanian, Jessica L Davis, Erin Rudzinski, Angela M Feraco, Brian B Tuch, Kevin T Ebata, Mark Reynolds, Steven Smith, Scott Cruickshank, Michael C Cox, Alberto S Pappo, Douglas S Hawkins
BACKGROUND: Gene fusions involving NTRK1, NTRK2, or NTRK3 (TRK fusions) are found in a broad range of paediatric and adult malignancies. Larotrectinib, a highly selective small-molecule inhibitor of the TRK kinases, had shown activity in preclinical models and in adults with tumours harbouring TRK fusions. This study aimed to assess the safety of larotrectinib in paediatric patients. METHODS: This multicentre, open-label, phase 1/2 study was done at eight sites in the USA and enrolled infants, children, and adolescents aged 1 month to 21 years with locally advanced or metastatic solid tumours or CNS tumours that had relapsed, progressed, or were non-responsive to available therapies regardless of TRK fusion status; had a Karnofsky (≥16 years of age) or Lansky (<16 years of age) performance status score of 50 or more, adequate organ function, and full recovery from the acute toxic effects of all previous anticancer therapy...
March 29, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29599325/blocking-the-cleavage-of-filamin-a-by-calpain-inhibitor-decreases-tumor-cell-growth
#9
Reza Salimi, Sashidhar Bandaru, Sravani Devarakonda, Sevtap Gökalp, Chandu Ala, Ali Alvandian, Nilgün Yener, Levent M Akyürek
BACKGROUND/AIM: Filamin A (FLNA) is the most abundant and widely expressed isoform of filamin in human tissues. It is cleaved by calpain at the hinge 1 and 2 domains, producing a 90-kDa carboxyl-terminal fragment (FLNACT ). Recently, it has been shown that FLNACT mediates cell signaling and transports transcription factors into the cell nucleus. However, the significance of cleavage of FLNA by calpain has not been studied in cancer cell growth. Calpeptin is a chemical inhibitor of both calpain 1 and 2 that cleaves FLNA...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29596317/distribution-of-glutathione-stabilized-gold-nanoparticles-in-feline-fibrosarcomas-and-their-role-as-a-drug-delivery-system-for-doxorubicin-preclinical-studies-in-a-murine-model
#10
Katarzyna Zabielska-Koczywąs, Anna Wojtalewicz, Ewelina Użarowska, Agata Klejman, Agata Wojtkowska, Izabella Dolka, Marek Wojnicki, Katarzyna Sobczak, Michał Wójcik, Haifa Shen, Mauro Ferrari, Roman Lechowski
Feline injection site sarcomas (FISS) are malignant skin tumors with high recurrence rates despite the primary treatment of radical surgical resections. Adjunctive radiotherapy or chemotherapy with doxorubicin is mostly ineffective. Cellular and molecular causes of multidrug resistance, specific physio-chemical properties of solid tumors impairing drug transport, and the tumor microenvironment have been indicated for causing standard chemotherapy failure. Gold nanoparticles are promising imaging tools, nanotherapeutics, and drug delivery systems (DDS) for chemotherapeutics, improving drug transport within solid tumors...
March 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29587914/-surgical-treatment-of-refractory-chest-tumors-assisted-by-cardiopulmonary-bypass
#11
Rongying Zhu, Shanzhou Duan, Wentao Yang, Li Shi, Fuquan Zhang, Yongbing Chen
BACKGROUND: A retrospective review of the surgical treatment of refractory chest tumors involving the heart or large vessels with cardiopulmonary bypass (CPB). METHODS: To summarize 11 cases of chest tumor patients who had undergone cardiopulmonary bypass surgery from January 2008 to May 2017 in our hospital, and analyze the general condition, clinical characteristics, treatment methods, postoperative hospitalization time, complications and follow-up results of all patients...
April 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29574223/spinal-sclerosing-epithelioid-fibrosarcoma-at-the-cervicothoracic-junction
#12
Jing Zhang, Dean Chou
BACKGROUND: Sclerosing epithelioid fibrosarcoma (SEF) is an unusual variant of fibrosarcoma that was previously considered to be a low-grade tumor with an indolent course. To our knowledge, the spine is a rare primary site for SEF, with only a few cases reported to date. CASE DESCRIPTION: We report a case of SEF occurring in the cervicothoracic spine of a 64-year-old male with complaints of neck pain and right hand tingling for 6 months prior to presentation. Imaging revealed a large mass that extended from C5 to T1 in the right posterior paraspinal soft tissues, involvement of the posterior elements from C6 to T1, and infiltration of the T1 vertebral body...
March 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29553955/ntrk-fusions-define-a-novel-uterine-sarcoma-subtype-with-features-of-fibrosarcoma
#13
Sarah Chiang, Paolo Cotzia, David M Hyman, Alexander Drilon, William D Tap, Lei Zhang, Jaclyn F Hechtman, Denise Frosina, Achim A Jungbluth, Rajmohan Murali, Kay J Park, Robert A Soslow, Esther Oliva, A John Iafrate, Ryma Benayed, Marc Ladanyi, Cristina R Antonescu
Tropomyosin receptor kinase (Trk) inhibitors have shown high response rates in patients with tumors harboring NTRK fusions. We identified 4 NTRK fusion-positive uterine sarcomas that should be distinguished from leiomyosarcoma and undifferentiated uterine sarcoma. NTRK rearrangements were detected by fluorescence in situ hybridization (FISH) and/or targeted RNA or DNA sequencing in 4 undifferentiated uterine sarcomas with spindle cell morphology. Because of histologic overlap with leiomyosarcoma, TrkA and pan-Trk immunohistochemistry was performed in 97 uterine leiomyosarcomas...
March 16, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29547709/triterpenoid-saponins-from-scabiosa-stellata-collected-in-north-eastern-algeria
#14
Meryem Lehbili, Abdulmagid Alabdul Magid, Ahmed Kabouche, Laurence Voutquenne-Nazabadioko, Hamid Morjani, Dominique Harakat, Zahia Kabouche
Eight undescribed triterpenoid saponins, scabiostellatosides A-H, together with three known compounds were isolated from the whole plant of Scabiosa stellata L. Their structures were established by spectroscopic analyses (1D, 2D-NMR and HRESIMS) and chemical methods. Scabiostellatosides A-H were evaluated for their cytotoxicity against human fibrosarcoma cell line (HT1080). Scabiostellatoside F, a heptasaccharide derivative of oleanolic acid, exhibited moderate cytotoxicity against HT1080 cell line with IC50 value of 12...
March 12, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29545133/endoglin-based-in-vivo-near-infrared-fluorescence-imaging-of-tumor-models-in-mice-using-activatable-liposomes
#15
Felista L Tansi, Ronny Rüger, Ansgar M Kollmeier, Markus Rabenhold, Frank Steiniger, Roland E Kontermann, Ulf K Teichgraeber, Alfred Fahr, Ingrid Hilger
BACKGROUND: Endoglin (CD105) is overexpressed on tumor cells and tumor vasculatures, making it a potential target for diagnostic imaging and therapy of different neoplasms. Therefore, studies on nanocarrier systems designed for endoglin-directed diagnostic and drug delivery purposes would expose the feasibility of targeting endoglin with therapeutics. METHODS: Liposomes carrying high concentrations of a near-infrared fluorescent dye in the aqueous interior were prepared by the lipid film hydration and extrusion procedure, then conjugated to single chain antibody fragments either selective for murine endoglin (termed mEnd-IL) or directed towards human endoglin (termed hEnd-IL)...
March 12, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29541234/-in-vitro-anticancer-effects-of-a-rage-inhibitor-discovered-using-a-structure-based-drug-design-system
#16
Ali Hafez Ali Mohammed El-Far, Seiichi Munesue, Ai Harashima, Akira Sato, Mika Shindo, Shingo Nakajima, Mana Inada, Mariko Tanaka, Akihiko Takeuchi, Hiroyuki Tsuchiya, Hiroshi Yamamoto, Hazem M E Shaheen, Yasser S El-Sayed, Shuhei Kawano, Sei-Ichi Tanuma, Yasuhiko Yamamoto
Receptor for advanced glycation end-products (RAGE) is a pattern recognition receptor implicated in the pathogenesis of certain types of cancer. In the present study, papaverine was identified as a RAGE inhibitor using the conversion to small molecules through optimized-peptide strategy drug design system. Papaverine significantly inhibited RAGE-dependent nuclear factor κ-B activation driven by high mobility group box-1, a RAGE ligand. Using RAGE- or dominant-negative RAGE-expressing HT1080 human fibrosarcoma cells, the present study revealed that papaverine suppressed RAGE-dependent cell proliferation and migration dose-dependently...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29529946/correlation-between-raf-mek-erk-signaling-pathway-and-clinicopathological-features-and-prognosis-for-patients-with-breast-cancer-having-axillary-lymph-node-metastasis
#17
Guo-Li Shao, Meng-Chuan Wang, Xu-Long Fan, Lin Zhong, Shu-Feng Ji, Guo Sang, Shui Wang
OBJECTIVE: This study aims to investigate the correlations between rapidly accelerated fibrosarcoma/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase signaling pathway and clinicopathological features and prognosis for patients with breast cancer having axillary lymph node metastasis. METHODS: A total of 118 breast cancer tissues with axillary lymph node metastasis (axillary lymph node metastasis group), 150 breast cancer tissues with non-axillary lymph node metastasis (non-axillary lymph node metastasis group), and 216 normal breast tissues (normal group) were enrolled in this study...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29529600/long-noncoding-rna-meg3-regulates-mafa-expression-in-mouse-beta-cells-by-inactivating-rad21-smc3-or-sin3%C3%AE
#18
Ning Wang, Yanan Zhu, Min Xie, Lintao Wang, Feiyan Jin, Yihui Li, Qingxin Yuan, Wei De
BACKGROUND/AIMS: The main pathogenic mechanism of diabetes is a decrease in the number of islet beta cells or a decline in their function. Recent studies have shown that pancreatic long noncoding RNAs (lncRNAs) have a high degree of tissue specificity and may be involved in the maintenance of islet cells function and the development of diabetes. The aim of this study was to investigate the molecular regulatory mechanism of mouse maternal expressed gene 3 (Meg3) in insulin biosynthesis in pancreatic islets...
March 6, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29518973/new-terpenoids-from-chamaecyparis-formosensis-cupressaceae-leaves-with-modulatory-activity-on-matrix-metalloproteases-2-and-9
#19
Meng-Lun Chang, Hui-Ching Mei, I-Chih Kuo, George Hsiao, Yueh-Hsiung Kuo, Ching-Kuo Lee
Chamaecyparis formosensis is Taiwan's most representative tree, and has high economic value. To date, only a few active chemical constituents have been reported for C. formosensis . In this study, 37 secondary metabolites, including three new compounds ( 1 - 3 ), were extracted from the leaves of C. formosensis . The compounds isolated from the ethyl acetate layer were used at different concentrations to treat HT-1080 human fibrosarcoma cells and to evaluate their effects on matrix metalloprotease 2 (MMP-2) and 9 (MMP-9) expression...
March 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29506145/role-of-acid-sphingomyelinase-and-ceramide-in-mechano-acoustic-enhancement-of-tumor-radiation-responses
#20
Ahmed El Kaffas, Azza Al-Mahrouki, Amr Hashim, Niki Law, Anoja Giles, Gregory J Czarnota
Background: High-dose radiotherapy (>8-10 Gy) causes rapid endothelial cell death via acid sphingomyelinase (ASMase)-induced ceramide production, resulting in biologically significant enhancement of tumor responses. To further augment or solicit similar effects at low radiation doses, we used genetic and chemical approaches to evaluate mechano-acoustic activation of the ASMase-ceramide pathway by ultrasound-stimulated microbubbles (USMB). Methods: Experiments were carried out in wild-type and acid sphingomyelinase (asmase) knockout mice implanted with fibrosarcoma xenografts...
February 28, 2018: Journal of the National Cancer Institute
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