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https://www.readbyqxmd.com/read/28317309/infantile-fibrosarcoma-treated-with-postoperative-vincristine-and-dactinomycin
#1
Hiroki Yoshihara, Yuri Yoshimoto, Yosuke Hosoya, Daisuke Hasegawa, Takafumi Kawano, Akiko Sakoda, Hajime Okita, Atsushi Manabe
Infantile fibrosarcoma is a non-rhabdomyosarcoma soft-tissue sarcoma that occurs in infancy and which has a relatively good prognosis. A vincristine and dactinomycin (VA) regimen has been shown to be effective, although the duration of chemotherapy has not been well defined. We describe the case of a 4-month-old boy with a mass at the left dorsum of the foot who was diagnosed with infantile fibrosarcoma after resection of the tumor, the margin of which was macroscopically positive. VA treatment was carried out with careful monitoring of response and adverse effects...
March 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28286052/a-systems-biology-approach-to-overcome-trail-resistance-in-cancer-treatment
#2
REVIEW
Kumar Selvarajoo
Over the last decade, our research team has investigated the dynamic responses and global properties of living cells using systems biology approaches. More specifically, we have developed computational models and statistical techniques to interpret instructive cell signaling and high-throughput transcriptome-wide behaviors of immune, cancer, and embryonic development cells. Here, I will focus on our recent works in overcoming cancer resistance. TRAIL (tumor necrosis factor related apoptosis-inducing ligand), a proinflammatory cytokine, has shown promising success in controlling cancer threat due to its ability to induce apoptosis in cancers specifically, while having limited effect on normal cells...
March 9, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28282121/mass-spectrometry-based-proteomics-study-of-cisplatin-induced-dna-protein-cross-linking-in-human-fibrosarcoma-ht1080-cells
#3
Xun Ming, Erin D Michaelson-Richie, Arnold Groehler, Peter W Villalta, Colin Campbell, Natalia Y Tretyakova
Platinum-based antitumor drugs such as 1,1,2,2-cis-diamminedichloroplatinum(II) (cisplatin), carboplatin, and oxaliplatin are currently used to treat nearly 50% of all cancer cases, and novel platinum based agents are under development. The antitumor effects of cisplatin and other platinum compounds are attributed to their ability to induce interstrand DNA-DNA cross-links, which are thought to inhibit tumor cell growth by blocking DNA replication and/or preventing transcription. However, platinum agents also induce significant numbers of unusually bulky and helix-distorting DNA-protein cross-links (DPCs), which are poorly characterized because of their unusual complexity...
March 10, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28277540/p53-loss-of-heterozygosity-is-a-necessary-prerequisite-for-mutant-p53-stabilization-and-gain-of-function-in-vivo
#4
Evguenia M Alexandrova, Safia A Mirza, Sulan Xu, Ramona Schulz-Heddergott, Natalia D Marchenko, Ute M Moll
Missense mutations in TP53 comprise >75% of all p53 alterations in cancer, resulting in highly stabilized mutant p53 proteins that not only lose their tumor-suppressor activity, but often acquire oncogenic gain-of-functions (GOFs). GOF manifests itself in accelerated tumor onset, increased metastasis, increased drug resistance and shortened survival in patients and mice. A known prerequisite for GOF is mutant p53 protein stabilization, which itself is linked to aberrant protein conformation. However, additional determinants for mutant p53 stabilization likely exist...
March 9, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28272394/amigo2-upregulation-in-tumour-cells-facilitates-their-attachment-to-liver-endothelial-cells-resulting-in-liver-metastases
#5
Yusuke Kanda, Mitsuhiko Osaki, Kunishige Onuma, Ayana Sonoda, Masanobu Kobayashi, Junichi Hamada, Garth L Nicolson, Takahiro Ochiya, Futoshi Okada
Since liver metastasis is the main cause of death in cancer patients, we attempted to identify the driver gene involved. QRsP-11 fibrosarcoma cells were injected into the spleens of syngeneic mice to isolate tumour sub-populations that colonize the liver. Cells from liver metastatic nodules were established and subsequently injected intrasplenically for selection. After 12 cycles, the cell subline LV12 was obtained. Intravenous injection of LV12 cells produced more liver metastases than QRsP-11 cells, whereas the incidence of lung metastases was similar to that of QRsP-11 cells...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28270508/discoidin-domain-receptor-2-mediates-collagen-induced-activation-of-membrane-type-1-matrix-metalloproteinase-in-human-fibroblasts
#6
Iwona Majkowska, Yasuyuki Shitomi, Noriko Ito, Nathanael S Gray, Yoshifumi Itoh
Membrane-Type 1 Matrix Metalloproteinase (MT1-MMP) is a membrane-bound MMP that is highly expressed in cells with invading capacity including fibroblasts and invasive cancer cell. A potential physiological stimulus for MT1-MMP expression is fibrillar collagen, and it has been shown that it upregulates both MT1-MMP gene and functions in various cell types. However, the mechanisms of collagen-mediated MT1-MMP activation is not clearly understood. In this study we identified discoidin domain receptor 2 (DDR2) as a crucial receptor that mediates this process in human fibroblasts...
March 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28270135/is-cancer-a-pure-growth-curve-or-does-it-follow-a-kinetics-of-dynamical-structural-transformation
#7
Maraelys Morales González, Javier Antonio González Joa, Luis Enrique Bergues Cabrales, Ana Elisa Bergues Pupo, Baruch Schneider, Suleyman Kondakci, Héctor Manuel Camué Ciria, Juan Bory Reyes, Manuel Verdecia Jarque, Miguel Angel O'Farril Mateus, Tamara Rubio González, Soraida Candida Acosta Brooks, José Luis Hernández Cáceres, Gustavo Victoriano Sierra González
BACKGROUND: Unperturbed tumor growth kinetics is one of the more studied cancer topics; however, it is poorly understood. Mathematical modeling is a useful tool to elucidate new mechanisms involved in tumor growth kinetics, which can be relevant to understand cancer genesis and select the most suitable treatment. METHODS: The classical Kolmogorov-Johnson-Mehl-Avrami as well as the modified Kolmogorov-Johnson-Mehl-Avrami models to describe unperturbed fibrosarcoma Sa-37 tumor growth are used and compared with the Gompertz modified and Logistic models...
March 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28270078/a-preliminary-study-of-the-action-of-virtosomes-from-non-dividing-cells-on-tumour-cell-replication-in-vitro-and-in-vivo
#8
Mariano Garcia-Arranz, Damian Garcia-Olmo, Luz Vega-Clemente, Maurice Stroun
BACKGROUND: A DNA-RNA-lipoprotein complex, termed a virtosome, is released spontaneously from healthy human, other mammalian, avian, amphibian and plant cells in a regulated and energy-dependent manner. Studies on human and mouse lymphocytes, hepatocytes, NIH 3T3 cells and mouse tumour cell lines have shown that virtosomes may be acting as inter-cellular messengers. In particular, virtosomes from non-dividing cells blocked 3H-thymidine incorporation into DNA in tumour cell lines. OBJECTIVE: Study of the effect of virtosomes on tumors "in vivo" and "in vitro" Methods and Results...
February 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28268995/low-frequency-ultrasound-radiosensitization-and-therapy-response-monitoring-of-tumors-an-in-vivo-study
#9
Ali Sadeghi-Naini, Martin Stanisz, Hadi Tadayyon, Jaswinder Taank, Gregory J Czarnota
A new framework has been introduced in this paper for tumor radiosensitization and therapy response monitoring using low-frequency ultrasound. Human fibrosarcoma xenografts grown in severe combined immunodeficiency (SCID) mice (n = 108) were treated using ultrasound-stimulated microbubbles at various concentration and exposed to different doses of radiation. Low-frequency ultrasound radiofrequency (RF) data were acquired from tumors prior to and at different times after treatment. Quantitative ultrasound (QUS) techniques were applied to generate spectral parametric maps of tumors...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263097/transcriptional-and-epigenetic-regulation-of-follicular-t-helper-cells-and-their-role-in-autoimmunity
#10
Hong Qiu, Haijing Wu, Vera Chan, Chak-Sing Lau, Qianjin Lu
T-follicular helper (Tfh) cells are a specialized subset of T cells that provide help to B cells and promote the formation of germinal centers (GCs). Tfh cells transmit important signals to B cells that drive class switch recombination, somatic hyper-mutation, the generation of high-affinity antibodies, immunological memory and their differentiation into plasma cells or memory B cells in the GCs. Tfh-cell differentiation is regulated by the coordinated functions of distinct cytokines, including interleukin (IL)-6, IL-21, IL-12, IL-23, IL-2, IL-7 and transforming growth factor-β (TGF-β), as well as transcription factors, including B-cell lymphoma 6 protein (Bcl-6), Signal transducers and activators of transcription (STAT)1, STAT3, STAT4, B-cell activating transcription factor (Batf), interferon regulatory factor 4 (IRF4), v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog (C-Maf), T-cell-specific transcription factor 1 (TCF-1) and Achaete-scute homolog 2 (Acl2), which have been shown to form a complex transcriptional network...
March 2017: Autoimmunity
https://www.readbyqxmd.com/read/28261869/intraventricular-gliosarcoma-with-dual-sarcomatous-differentiation-a-unique-case
#11
Rajalakshmi Poyuran, Nandeesh Bn, Yerasi Varun Kumar Reddy, Amey R Savardekar
Gliosarcoma, a variant of isocitrate dehydrogenase-wildtype glioblastoma, is largely a lobar surfacing neoplasm often with dural attachment. In this biphasic neoplasm, the sarcomatous component usually takes the form of fibrosarcoma or malignant fibrous histiocytoma. Heterologous sarcomatous differentiation is a rare phenomenon. Here, we present a case of gliosarcoma with liposarcomatous and myosarcomatous differentiation in a 68-year-old man which was purely intraventricular. This is the first report of such a morphologic pattern in this location...
March 6, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28256570/recurrent-bcor-internal-tandem-duplication-and-bcor-or-bcl6-expression-distinguish-primitive-myxoid-mesenchymal-tumor-of-infancy-from-congenital-infantile-fibrosarcoma
#12
Teresa Santiago, Michael R Clay, Sariah J Allen, Brent A Orr
Primitive myxoid mesenchymal tumor of infancy is a rare sarcoma that preferentially affects infants. It can be locally aggressive and rarely metastasizes, but the long-term outcome of children with this tumor is mostly unknown. Histologically, it is characterized by primitive cells with abundant myxoid stroma. Internal tandem duplication of B-cell CLL/lymphoma 6 (BCL6)-interacting co-repressor (BCOR) exon 15 has recently been described in clear cell sarcoma of kidney, central nervous system high-grade neuroepithelial tumor with BCOR alteration, and primitive myxoid mesenchymal tumor of infancy...
March 3, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28227205/low-frequency-ultrasound-radiosensitization-and-therapy-response-monitoring-of-tumors-an-in-vivo-study
#13
Ali Sadeghi-Naini, Martin Stanisz, Hadi Tadayyon, Jaswinder Taank, Gregory J Czarnota, Ali Sadeghi-Naini, Martin Stanisz, Hadi Tadayyon, Jaswinder Taank, Gregory J Czarnota, Jaswinder Taank, Hadi Tadayyon, Martin Stanisz, Ali Sadeghi-Naini, Gregory J Czarnota
A new framework has been introduced in this paper for tumor radiosensitization and therapy response monitoring using low-frequency ultrasound. Human fibrosarcoma xenografts grown in severe combined immunodeficiency (SCID) mice (n = 108) were treated using ultrasound-stimulated microbubbles at various concentration and exposed to different doses of radiation. Low-frequency ultrasound radiofrequency (RF) data were acquired from tumors prior to and at different times after treatment. Quantitative ultrasound (QUS) techniques were applied to generate spectral parametric maps of tumors...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224623/outcome-and-prognostic-factors-following-curative-intent-surgery-for-oral-tumours-in-dogs-234-cases-2004-to-2014
#14
B N Sarowitz, G J Davis, S Kim
OBJECTIVES: To describe the long-term outcomes and prognostic factors associated with curative-intent surgery for oral tumours in a large series of dogs. METHODS: Retrospective review of records for dogs with oral tumours treated with curative-intent surgery. Data collected included signalment, weight, surgical procedure, lymph node staging results, computed tomography results, tumour size, histopathology results including margin evaluation, complications, adjunctive therapies, local recurrence or metastasis, date and cause of death and owner satisfaction...
February 22, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28222111/a-meta-analysis-of-the-abscopal-effect-in-preclinical-models-is-the-biologically-effective-dose-a-relevant-physical-trigger
#15
Raffaella Marconi, Silvia Strolin, Gianluca Bossi, Lidia Strigari
BACKGROUND: Preclinical in vivo studies using small animals are considered crucial in translational cancer research and clinical implementation of novel treatments. This is of paramount relevance in radiobiology, especially for any technological developments permitted to deliver high doses in single or oligo-fractionated regimens, such as stereotactic ablative radiotherapy (SABR). In this context, clinical success in cancer treatment needs to be guaranteed, sparing normal tissue and preventing the potential spread of disease or local recurrence...
2017: PloS One
https://www.readbyqxmd.com/read/28218026/gingival-fibrosarcoma-in-a-horse
#16
Apryle Horbal, Padraic M Dixon
A 4-year-old thoroughbred cross mare was referred to the University of Edinburgh Veterinary School Equine Hospital for treatment of a soft tissue tumor on the buccal gingival margin of the rostral right maxillary cheek teeth. The lesion was initially surgically excised and diagnosed as a fibrosarcoma via histopathology. Adjunctive treatment with intralesional cisplatin chemotherapy was begun. The tumor recurred and was repeatedly treated with intralesional cisplatin injections and additional surgical resection over the course of 14 weeks...
December 2016: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28208720/doxorubicin-conjugated-to-glutathione-stabilized-gold-nanoparticles-au-gsh-dox-as-an-effective-therapeutic-agent-for-feline-injection-site-sarcomas-chick-embryo-chorioallantoic-membrane-study
#17
Katarzyna Zabielska-Koczywąs, Izabella Dolka, Magdalena Król, Artur Żbikowski, Wiktor Lewandowski, Józef Mieczkowski, Michał Wójcik, Roman Lechowski
Feline injection-site sarcomas are malignant skin tumours with a high local recurrence rate, ranging from 14% to 28%. The treatment of feline injection-site sarcomas includes radical surgery, radiotherapy and/or chemotherapy. In our previous study it has been demonstrated that doxorubicin conjugated to glutathione-stabilized gold nanoparticles (Au-GSH-Dox) has higher cytotoxic effects than free doxorubicin for feline fibrosarcoma cell lines with high glycoprotein P activity (FFS1, FFS3). The aim of the present study was to assess the effectiveness of intratumoural injection of Au-GSH-Dox on the growth of tumours from the FFS1 and FFS3 cell lines on chick embryo chorioallantoic membrane...
February 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28205098/enhanced-cellular-functions-through-induction-of-lpa2-by-cisplatin-in-fibrosarcoma-ht1080-cells
#18
Kaede Takahashi, Kaori Fukushima, Nobuyuki Fukushima, Kanya Honoki, Toshifumi Tsujiuchi
Lysophosphatidic acid (LPA) is a simple biophysical lipid which interacts with at least six subtypes of G protein-coupled LPA receptors (LPA1-LPA6). In cancer cells, LPA signaling via LPA receptors is involved in the regulation of malignant properties, such as cell growth, motility, and invasion. The aim of this study was to assess whether LPA receptors regulate cellular functions of fibrosarcoma cells treated with anticancer drug. HT1080 cells were maintained by the stepwise treatment of cisplatin (CDDP) at a range of 0...
February 15, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28198545/the-therapeutic-t-cell-response-induced-by-tumor-delivery-of-tnf-and-melphalan-is-dependent-on-early-triggering-of-natural-killer-and-dendritic-cells
#19
Enrica Balza, Silvia Zanellato, Alessandro Poggi, Daniele Reverberi, Anna Rubartelli, Lorenzo Mortara
The fusion protein L19mTNF (mouse TNF and human antibody fragment L19 directed to fibronectin extra domain-B) selectively targets the tumor vasculature, and in combination with melphalan induces a long-lasting T-cell therapeutic response and immune memory in murine models. Increasing evidence suggests that natural killer (NK) cells act to promote effective T-cell-based antitumor responses. We have analyzed the role of NK cells and dendritic cells (DCs) on two different murine tumor models: WEHI-164 fibrosarcoma and C51 colon carcinoma, in which the combined treatment induces high and low rejection rates respectively...
February 15, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28195246/cellular-fibroma-in-the-douglas-cavity-mimicking-a-malignant-neoplasia-fibroma-fibrosarcoma-or-mitotically-active-cellular-fibroma
#20
A Di Lorito, P Viola, S Rosini, G Lattanzio
INTRODUCTION: Ovarian fibroma is a benign stromal tumour composed of spindle/ovoid fibroblastic cells producing collagen. Approximally 10% of fibromas are densely cellular with small amount of collagen. In these cases, if mild nuclear atypia is present, they are best addressed as cellular fibroma. However cellular fibroma may show a greater mitotic activity and therefore they should be referred as mitotically active cellular fibromas. Mostly benign, it is necessary to differentiate them from malignant tumours such as fibrosarcomas...
March 2016: Pathologica
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