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Fibrosarcoma

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https://www.readbyqxmd.com/read/29243803/effect-of-metformin-on-fibrosarcoma-in-hamsters
#1
D J Popović, D Lalošević, D Miljković, K J Popović, I Čapo, J K Popović
OBJECTIVE: We investigated the effect of metformin on an in vivo solid tumor model of fibrosarcoma in hamsters. MATERIALS AND METHODS: 33 Syrian golden hamsters of both sexes, weighing approximately 100 g, were randomly allocated to 3 experimental and 2 control groups. 2 x 106 BHK-21/C13 cells in 1 ml were injected subcutaneously into the animals' back in 4 groups. The first experimental group (7 animals) started peroral treatment with metformin 500 mg/kg daily via a gastric probe 7 days before tumor inoculation, the second (8 animals) 3 days before inoculation and the third (6 animals) immediately after inoculation...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228606/identifying-tumor-promoting-genomic-alterations-in-tumor-associated-fibroblasts-via-retrovirus-insertional-mutagenesis
#2
Lijie Rong, Yangyang Bian, Shubai Liu, Xiaoman Liu, Xiao Li, Haiyang Liu, Jinxue Zhou, Jirun Peng, Henghui Zhang, Hongsong Chen, Zhihai Qin
Tumor-associated fibroblasts (TAFs) are often essential for solid tumor growth. However, few genetic or epigenetic alterations have been found in TAFs during the progression of solid tumors. Employing a tumor-stromal cell co-injection model, we adapted here retroviral-insertional mutagenesis to stromal cells to identify novel tumor-associated genes in TAFs. We successfully identified 20 gene candidates that might modulate tumor growth if altered in TAFs at genomic level. To validate our finding, the function of one of the candidate genes, tubulin tyrosine ligase (Ttl), was further studied in TAFs from fibrosarcoma, colon, breast and hepatocarcinoma...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221156/the-protective-role-of-sphingosine-1-phosphate-against-the-action-of-the-vascular-disrupting-agent-combretastatin-a-4-3-o-phosphate
#3
Joanna Shepherd, Matthew Fisher, Abigail Welford, Donald M McDonald, Chryso Kanthou, Gillian M Tozer
Solid tumours vary in sensitivity to the vascular disrupting agent combretastatin A-4 3-O-phosphate (CA4P), but underlying factors are poorly understood. The signaling sphingolipid, sphingosine-1-phosphate (S1P), promotes vascular barrier integrity by promoting assembly of VE-cadherin/β-catenin complexes. We tested the hypothesis that tumour pre-treatment with S1P would render tumours less susceptible to CA4P. S1P (1μM) pretreatment attenuated an increase in endothelial cell (HUVEC) monolayer permeability induced by 10μM CA4P...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29216821/molecular-targets-and-signaling-pathways-regulated-by-nuclear-translocation-of-syndecan-1
#4
Tünde Szatmári, Filip Mundt, Ashish Kumar-Singh, Lena Möbus, Rita Ötvös, Anders Hjerpe, Katalin Dobra
BACKGROUND: The cell-surface heparan sulfate proteoglycan syndecan-1 is important for tumor cell proliferation, migration, and cell cycle regulation in a broad spectrum of malignancies. Syndecan-1, however, also translocates to the cell nucleus, where it might regulate various molecular functions. RESULTS: We used a fibrosarcoma model to dissect the functions of syndecan-1 related to the nucleus and separate them from functions related to the cell-surface. Nuclear translocation of syndecan-1 hampered the proliferation of fibrosarcoma cells compared to the mutant lacking nuclear localization signal...
December 8, 2017: BMC Cell Biology
https://www.readbyqxmd.com/read/29200168/spontaneous-regression-in-a-patient-with-infantile-fibrosarcoma
#5
Sameer Farouk Sait, Enrico Danzer, Daniel Ramirez, Michael P LaQuaglia, Meyers Paul
Infantile fibrosarcoma usually presents as a rapidly growing mass on the extremities or trunk. We describe spontaneous regression in a 5-month-old female infant with biopsy proven, molecularly confirmed, right leg infantile fibrosarcoma currently at 26 months of age with no signs of local recurrence. Previously reported cases of spontaneous regression are reviewed, suggesting a benign clinical course in some cases. Although evidence for spontaneous regression is anecdotal in this rare tumor type, physicians should weigh the risks and benefits of surgery and chemotherapy against watchful waiting...
December 1, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29198034/population-level-effect-of-molecular-testing-and-targeted-therapy-in-patients-with-advanced-pulmonary-adenocarcinoma-a-prospective-cohort-study
#6
Christine Schwegler, Dinu Kaufmann, David Pfeiffer, Stefan Aebi, Joachim Diebold, Oliver Gautschi
Large cancer centres in the USA demonstrated that molecular diagnosis and targeted therapy improved overall survival of patients with advanced pulmonary adenocarcinoma. We validated this finding in a rural area of Switzerland, served by private practices, community hospitals and a tertiary referral centre. We conducted a prospective cohort study with the Cancer Registry of Central Switzerland, covering 4 cantons and 517,000 inhabitants. All residents newly diagnosed with stage IV pulmonary adenocarcinoma from 2010 to 2014 were enrolled...
December 2, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29194391/impaired-osteogenesis-of-disease-specific-induced-pluripotent-stem-cells-derived-from-a-cfc-syndrome-patient
#7
Jung-Yun Choi, Kyu-Min Han, Dongkyu Kim, Beom-Hee Lee, Han-Wook Yoo, Jin-Ho Choi, Yong-Mahn Han
Cardiofaciocutaneous (CFC) syndrome is a rare genetic disorder caused by mutations in the extracellular signal-regulated kinase (ERK) signaling. However, little is known about how aberrant ERK signaling is associated with the defective bone development manifested in most CFC syndrome patients. In this study, induced pluripotent stem cells (iPSCs) were generated from dermal fibroblasts of a CFC syndrome patient having rapidly accelerated fibrosarcoma kinase B (BRAF) gain-of-function mutation. CFC-iPSCs were differentiated into mesenchymal stem cells (CFC-MSCs) and further induced to osteoblasts in vitro...
December 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29193082/a-preliminary-investigation-of-the-effect-of-sample-collection-technique-on-the-cell-and-rna-content-of-fine-needle-aspirates-of-five-canine-tumours
#8
K L Bowlt Blacklock, J Ireland, J Stewart, S Murphy, L Blackwood, M Starkey
OBJECTIVES: To evaluate the effect of syringe size, needle size, number of needle passes and operator experience on cell yield from tumour fine-needle aspirates, and the quantity and quality of extractable RNA. MATERIALS AND METHODS: Fine-needle aspirates were collected from canine lymphoma, cutaneous mast cell tumour, anal gland adenocarcinoma, fibrosarcoma and oral malignant melanoma using nine different techniques. RESULTS: There was a significant difference in cell yield between fine-needle aspirate techniques for melanoma, lymphoma and anal gland adenocarcinoma...
November 29, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29189868/-breast-osteosarcoma-originating-in-a-phyllodes-tumor-report-of-one-case
#9
Tereza Nieto-Coronel, Jessica Elizabeth Salazar-Campos, David Cantú de León, Raúl Díaz-Molina, Rafael Vázquez-Romo, Enrique Bargalló-Rocha
Phyllodes tumors account for less than 1% of tumors of the mammary gland, have both epithelial and stromal components and are classified as benign, borderline and malignant. The malignant tumors are highly heterogeneous: they can differentiate to liposarcomas, fibrosarcomas, rhabdomyosarcomas, chondrosarcomas or osteosarcomas. The differentiation to osteosarcoma is extremely rare, constitutes 1.3% of cases and is very aggressive. The standard treatment of these tumors is surgical. The role of radiotherapy and chemotherapy is not clear...
August 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29172905/retrospective-study-of-more-than-9000-feline-cutaneous-tumours-in-the-united-kingdom-2006-2013
#10
Nicola T Ho, Ken C Smith, Melanie J Dobromylskyj
Objectives The aim of the study was to utilise a large database available from a UK-based, commercial veterinary diagnostic laboratory to ascertain the prevalence of different forms of cutaneous neoplasia within the feline population, and to detect any breed, sex or age predilections for the more common tumours. Methods Records from the laboratory were searched for feline submissions received between 31 May 2006 and 31 October 2013. For masses arising within the skin for which histopathology had been performed, the diagnosis was recorded together with the breed, age, sex and neuter status of the cat...
March 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29172833/a-systematic-review-of-targeted-agents-for-non-small-cell-lung-cancer
#11
Hannah H Vestergaard, Marcus R Christensen, Ulrik N Lassen
BACKGROUND: advanced-stage non-small cell lung cancer (NSCLC) is characterized by having limited treatment options and thus a poor prognosis. However, new treatment options, in the form of targeted agents (TA), have emerged during recent years. This systematic review aims to provide an overview of the accessible literature in PubMed evaluating TA used on NSCLC patients, and the resulting survival outcomes. METHOD: this systematic literature review was conducted by reviewing all relevant literature in PubMed...
November 25, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29155337/photodynamic-therapy-in-fibrosarcoma-balb-c-animal-model-observation-of-the-rebound-effect
#12
Etcheverry María Eugenia, Pasquale Miguel Ángel, Gutiérrez Anabella, Bibé Solange, Ponzinibbio Carlos, Poteca Horacio, Garavaglia Mario
In vivo spectrofluorometric analysis during photodynamic therapy (PDT) is a fundamental tool to obtain information about the drug bleaching kinetics. Using a portable spectrofluorometer with an excitation source emitting at 400nm wavelength and a spectral analyzer ranging from 500nm to 800nm, the evolution of the meta-tetra(hydroxyphenyl) chlorin (m-THPC) photosensitizer fluorescence spectrum at the tumoral tissue of BALB/c murines with fibrosarcoma located at their flank was followed up. Ex vivo fluorescence measurements of the tumor and skin were also performed with the aim of better characterizing the in vivo signal at different parts of the tumor...
November 16, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29139598/preparation-and-comparative-evaluation-of-99m-tc-hynic-cngr-and-99m-tc-hynic-peg2-cngr-as-tumor-targeting-molecular-imaging-probes
#13
Kusum Vats, Drishty Satpati, Rohit Sharma, Chandan Kumar, Haladhar Dev Sarma, Sharmila Banerjee
The tripeptide sequence NGR (asparagine-glycine-arginine) specifically recognizes aminopeptidase N (APN or CD13) receptors highly expressed on tumor cells as well as tumor vasculature. Thus NGR peptides can precisely deliver therapeutic and diagnostic compounds to CD13 expressing cancer sites. In this regard two NGR peptide ligands, HYNIC-c(NGR) and HYNIC-PEG2 -c(NGR) were synthesized, radiolabeled with (99m) Tc and evaluated in CD13-positive human fibrosarcoma HT-1080 tumor xenografts. The radiotracers, (99m) Tc-HYNIC-c(NGR) and (99m) Tc-HYNIC-PEG2 -c(NGR) could be prepared in ~95% radiochemical purity (RCP) and exhibited excellent in vitro and in vivo stability...
November 15, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29138682/mir-128-is-implicated-in-stress-responses-by-targeting-mafg-in-skeletal-muscle-cells
#14
Rocco Caggiano, Fabio Cattaneo, Ornella Moltedo, Giovanni Esposito, Cinzia Perrino, Bruno Trimarco, Rosario Ammendola, Raffaella Faraonio
MAFG (v-Maf avian musculoaponeurotic fibrosarcoma oncogene homolog G) is a bZIP-type transcriptional regulator that belongs to the small MAF (sMAFs) protein family. By interacting with other bZIP transcription factors, sMAFs can form homo- and heterodimers governing either repressive or activating transcriptional functions. As heterodimeric partner of Nrf2, MAFG positively influences the ARE-dependent antioxidant/xenobiotic pathways, at least in condition of a correct MAFG:Nrf2 balance. MicroRNAs (miRs) participate to different regulatory networks being involved as fine-tuning regulators of gene expression...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29130625/comparative-evaluation-of-68-ga-labeled-nodaga-dotaga-and-hbed-cc-conjugated-cngr-peptide-chelates-as-tumor-targeted-molecular-imaging-probes
#15
Drishty Satpati, Rohit Sharma, Haladhar Dev Sarma, Ashutosh Dash
The biological behavior of (68) Ga-based radiopharmaceuticals can be significantly affected by the chelators' attributes (size, charge, lipophilicity). Thus this study aimed at examining the influence of three different chelators, DOTAGA, NODAGA and HBED-CC on the distribution pattern of (68) Ga-labeled NGR peptides targeting CD13 receptors. (68) Ga-DOTAGA-c(NGR), (68) Ga-NODAGA-c(NGR) and (68) Ga-HBED-CC-c(NGR) were observed to be hydrophilic with respective log P values being -3.5±0.2, -3.3±0.08 and -2...
November 11, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29111484/self-calibrated-fluorescent-probe-resembled-as-an-indicator-of-the-lysosomal-phosphatase-pertaining-to-the-cancer-cells
#16
Arup Podder, Susan M Alex, Mrinmoy Maiti, Kaustabh Kumar Maiti, Sankarprasad Bhuniya
A self-calibrated fluorescent probe Lyso-Phos has synthesized followed by a straightforward synthetic pathway. Lyso-Phos acts as an indicator for lysosomal phosphatase. Its photophysical property including cellular imaging was described. Lyso-Phos showed ratiometric UV-Vis- absorption changes from λabs 370nm to λabs 450nm in the presence of alkaline phosphatase (ALP). On the other hand, fluorescence intensity λem 560nm of Lyso-Phos has increased around 45-fold in the presence of ALP. The probe Lyso-Phos was found to be highly chemoselective toward the phosphatase compared with other ubiquitous entities in cellular milieu...
October 18, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29109321/epidemiological-and-clinicopathological-analysis-of-92-odontogenic-tumors-a-5-year-retrospective-study
#17
Ipsita Sharma, Deepa Venkatesh, Geetanjali Bawa, Syed Vaseemuddin, Amit Joseph, Jimmy K Sangtani
INTRODUCTION: Odontogenic tumors (OTs) are a heterogeneous group of lesions that are derived from odontogenic apparatus comprised of odontogenic epithelium, ectomesenchyme, and/ or mesenchymal elements. The OTs show marked geographical variation. This study was conducted to analyze the epidemiology and clinicopathological presentation of OTs based on age, sex, and site. MATERIALS AND METHODS: This study was conducted in Department of Oral Pathology and Microbiology...
November 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29109116/mitochondrial-dynamics-and-respiration-within-cells-with-increased-open-pore-cytoskeletal-meshes
#18
David H Jang, Sarah C Seeger, Martha E Grady, Frances C Shofer, David M Eckmann
The cytoskeletal architecture directly affects the morphology, motility, and tensional homeostasis of the cell. In addition, the cytoskeleton is important for mitosis, intracellular traffic, organelle motility, and even cellular respiration. The organelle responsible for a majority of the energy conversion for the cell, the mitochondrion, has a dependence on the cytoskeleton for mobility and function. In previous studies, we established that cytoskeletal inhibitors altered the movement of the mitochondria, their morphology, and their respiration in human dermal fibroblasts...
November 6, 2017: Biology Open
https://www.readbyqxmd.com/read/29107054/selecting-the-correct-cellular-model-for-assessing-of-the-biological-response-of-collagen-based-biomaterials
#19
Natalia Davidenko, Samir Hamaia, Daniel V Bax, Jean-Daniel Malcor, Carlos F Schuster, Donald Gullberg, Richard W Farndale, Serena M Best, Ruth E Cameron
Accurate evaluation of the biological performance of biomaterials requires the correct assessment of their native-like cell ligation properties. However, cell attachment studies often overlook the details of the substrate-cell binding mechanisms, be they integrin-mediated or non-specific, and ignore the class- and species-specificities of the cell adhesion receptor involved. In this work we have used different collagen (Col) substrates (fibrillar collagens I, II and III and network-forming Col IV), containing different affinity cell-recognition motifs, to establish the influence of the receptor identity and species-specificity on collagen-cell interactive properties...
October 26, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29104242/synthesis-and-anti-proliferative-effects-of-mono-and-bis-purinomimetics-targeting-kinases
#20
Andrea Bistrović, Anja Harej, Petra Grbčić, Mirela Sedić, Sandra Kraljević Pavelić, Mario Cetina, Silvana Raić-Malić
A series of mono-pyrrolo[2,3-d]pyrimidines 4a-4k, unsymmetrical bis-purine isosteres 5a-5e and symmetrical bis-pyrrolo[2,3-d]pyrimidines 6a and 6b connected via di(1,2,3-triazolyl)phenyl linker were synthesized by click chemistry. Whereas mono- 4g and bis-pseudopurine 5e showed selective inhibitory activities on cervical carcinoma (HeLa) cells, bis-pyrrolo[2,3-d]pyrimidine 6b exhibited potent and selective anti-proliferative effect in the nanomolar range on pancreatic carcinoma (CFPAC-1) cells. Among these, compound 6b induced a significant reduction in the expression level of CDK9 (cyclin-dependent kinase 9)/cyclin T1 in CFPAC-1 cells concomitant with attenuation of proliferative signaling mediated by c-Raf (rapidly accelerated fibrosarcoma) and p38 MAP (mitogen-activated protein) kinases...
November 1, 2017: International Journal of Molecular Sciences
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