Yin P Hung, Adam S Fisch, Julio A Diaz-Perez, A John Iafrate, Jochen K Lennerz, Valentina Nardi, Miriam A Bredella, Kevin A Raskin, Santiago A Lozano-Calderon, Andrew E Rosenberg, G Petur Nielsen
AIMS: Simple bone cysts are benign intramedullary tumours primarily involving the long bones in skeletally immature individuals. Several mechanisms have been proposed for their pathogenesis. Although the diagnosis is typically straightforward, the interpretation can be problematic, because of superimposed fracture causing them to resemble aneurysmal bone cysts and other tumours. EWSR1-NFATC2 or FUS-NFATC2 fusions, which are characteristic of a subset of aggressive round cell sarcomas, have been recently detected in simple bone cysts...
May 2021: Histopathology