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https://www.readbyqxmd.com/read/29655597/affective-spectrum-symptoms-and-self-criticism-a-behavioral-genetic-approach
#1
Dries Bleys, Patrick Luyten, Stephan Claes, Bart Soenens
No abstract text is available yet for this article.
April 8, 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29651097/unraveling-the-compromised-biomechanical-performance-of-type-2-diabetes-and-roux-en-y-gastric-bypass-bone-by-linking-mechanical-structural-and-physico-chemical-properties
#2
Carlos Marin, Georgios Papantonakis, Kathleen Sels, G Harry van Lenthe, Guillaume Falgayrac, Roman Vangoitsenhoven, Bart Van der Schueren, Guillaume Penel, Frank Luyten, Katleen Vandamme, Greet Kerckhofs
Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with obesity and hyperglycemia. Roux-en-Y gastric bypass (RYGB) surgery is a common treatment for severely obese patients and T2DM. Both RYGB and T2DM are linked to increased skeletal fragility, though the exact mechanisms are poorly understood. Our aim was to characterize the structural, mechanical and compositional properties of bones from diet-induced obese and RYGB-treated obese (bypass) mice to elucidate which the exact factors are contributing to the increased skeletal fragility...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29626696/fine-tuning-pro-angiogenic-effects-of-cobalt-for-simultaneous-enhancement-of-vascular-endothelial-growth-factor-secretion-and-implant-neovascularization
#3
Yoke Chin Chai, Luis Freitas Mendes, Nick van Gastel, Geert Carmeliet, Frank P Luyten
Rapid neovascularization of a tissue-engineered (TE) construct by the host vasculature is quintessential to warrant effective bone regeneration. This process can be promoted through active induction of angiogenic growth factor secretion or by implementation of in vitro pre-vascularization strategies. In this study, we aimed at optimizing the pro-angiogenic effect of Cobalt (Co2+ ) to enhance vascular endothelial growth factor (VEGF) expression by human periosteum-derived mesenchymal stem cells (hPDCs). Simultaneously we set out to promote microvascular network formation by co-culturing with human umbilical vein endothelial cells (HUVECs)...
April 4, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29566658/punch-biopsies-shorten-time-to-clearance-of-high-risk-human-papillomavirus-infections-of-the-uterine-cervix
#4
K U Petry, J Horn, A Luyten, R T Mikolajczyk
BACKGROUND: The primary objective was to determine human papilloma virus (HPV) clearance rate after cervical biopsy among women with persistent high-risk HPV infection compared with spontaneous HPV clearance rate in the absence of biopsy. METHODS: We collected data from a dedicated screening program of women aged 30-70 years old. Inclusion criteria for the baseline non-interventional cohort were a positive HPV test (hybrid capture 2, HC2) and normal cytology. In the baseline cohort women were followed with approximately yearly HPV-tests and cytology until HPV regressed (one negative HPV test) or interventions in the form of diagnostic biopsies or therapy...
March 23, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29528842/antiparasitic-activity-in-asteraceae-with-special-attention-to-ethnobotanical-use-by-the-tribes-of-odisha-india
#5
Sujogya Kumar Panda, Walter Luyten
The purpose of this review is to survey the antiparasitic plants of the Asteraceae family and their applicability in the treatment of parasites. This review is divided into three major parts: (a) literature on traditional uses of Asteraceae plants for the treatment of parasites; (b) description of the major classes of chemical compounds from Asteraceae and their antiparasitic effects; and (c) antiparasitic activity with special reference to flavonoids and terpenoids. This review provides detailed information on the reported Asteraceae plant extracts found throughout the world and on isolated secondary metabolites that can inhibit protozoan parasites such as Plasmodium, Trypanosoma, Leishmania, and intestinal worms...
2018: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/29500393/essential-oils-and-their-components-are-a-class-of-antifungals-with-potent-vapour-phase-mediated-anti-candida-activity
#6
Adam F Feyaerts, Lotte Mathé, Walter Luyten, Stijn De Graeve, Katrien Van Dyck, Lize Broekx, Patrick Van Dijck
Multi-resistant microorganisms continue to challenge medicine and fuel the search for new antimicrobials. Here we show that essential oils and their components are a promising class of antifungals that can have specific anti-Candida activity via their vapour-phase. We quantify the vapour-phase-mediated antimicrobial activity (VMAA) of 175 essential oils and 37 essential oil components, representing more than a 1,000 unique molecules, against C. albicans and C. glabrata in a novel vapour-phase-mediated susceptibility assay...
March 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29478425/day-hospital-mentalization-based-treatment-v-specialist-treatment-as-usual-in-patients-with-borderline-personality-disorder-randomized-controlled-trial
#7
Elisabeth M P Laurenssen, Patrick Luyten, Martijn J Kikkert, Dieuwertje Westra, Jaap Peen, Mirjam B J Soons, Anne-Marie van Dam, Anna J van Broekhuyzen, Matthijs Blankers, Jan J V Busschbach, Jack J M Dekker
BACKGROUND: Day hospital mentalization-based treatment (MBT-DH) is a promising treatment for borderline personality disorder (BPD) but its evidence base is still limited. This multi-site randomized trial compared the efficacy of MBT-DH delivered by a newly set-up service v. specialist treatment as usual (S-TAU) tailored to the individual needs of patients, and offered by a well-established treatment service. METHODS: Two mental healthcare institutes in The Netherlands participated in the study...
February 26, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29467016/advancing-osteochondral-tissue-engineering-bone-morphogenetic-protein-transforming-growth-factor-and-fibroblast-growth-factor-signaling-drive-ordered-differentiation-of-periosteal-cells-resulting-in-stable-cartilage-and-bone-formation-in-vivo
#8
L F Mendes, H Katagiri, W L Tam, Y C Chai, L Geris, S J Roberts, F P Luyten
BACKGROUND: Chondrogenic mesenchymal stem cells (MSCs) have not yet been used to address the clinical demands of large osteochondral joint surface defects. In this study, self-assembling tissue intermediates (TIs) derived from human periosteum-derived stem/progenitor cells (hPDCs) were generated and validated for stable cartilage formation in vivo using two different animal models. METHODS: hPDCs were aggregated and cultured in the presence of a novel growth factor (GF) cocktail comprising of transforming growth factor (TGF)-β1, bone morphogenetic protein (BMP)2, growth differentiation factor (GDF)5, BMP6, and fibroblast growth factor (FGF)2...
February 21, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29459714/the-mycotoxin-phomoxanthone-a-disturbs-the-form-and-function-of-the-inner-mitochondrial-membrane
#9
Philip Böhler, Fabian Stuhldreier, Ruchika Anand, Arun Kumar Kondadi, David Schlütermann, Niklas Berleth, Jana Deitersen, Nora Wallot-Hieke, Wenxian Wu, Marian Frank, Hendrik Niemann, Elisabeth Wesbuer, Andreas Barbian, Tomas Luyten, Jan B Parys, Stefanie Weidtkamp-Peters, Andrea Borchardt, Andreas S Reichert, Aida Peña-Blanco, Ana J García-Sáez, Samuel Itskanov, Alexander M van der Bliek, Peter Proksch, Sebastian Wesselborg, Björn Stork
Mitochondria are cellular organelles with crucial functions in the generation and distribution of ATP, the buffering of cytosolic Ca2+ and the initiation of apoptosis. Compounds that interfere with these functions are termed mitochondrial toxins, many of which are derived from microbes, such as antimycin A, oligomycin A, and ionomycin. Here, we identify the mycotoxin phomoxanthone A (PXA), derived from the endophytic fungus Phomopsis longicolla, as a mitochondrial toxin. We show that PXA elicits a strong release of Ca2+ from the mitochondria but not from the ER...
February 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29458785/ecco-essential-requirements-for-quality-cancer-care-melanoma
#10
REVIEW
Michel W Wouters, Olivier Michielin, Esther Bastiaannet, Marc Beishon, Orlando Catalano, Veronique Del Marmol, Roberto Delgado-Bolton, Rémi Dendale, Maria Die Trill, Andrea Ferrari, Ana-Maria Forsea, Hannelore Kreckel, József Lövey, Gre Luyten, Daniela Massi, Peter Mohr, Simon Oberst, Philippe Pereira, João Paulo Paiva Prata, Piotr Rutkowski, Tiina Saarto, Sapna Sheth, Gilly Spurrier-Bernard, Meri-Sisko Vuoristo, Alberto Costa, Peter Naredi
BACKGROUND: ECCO essential requirements for quality cancer care (ERQCC) are explanations and descriptions of challenges, organisation and actions that are necessary to give high-quality care to patients who have a specific type of cancer. They are written by European experts representing all disciplines involved in cancer care. ERQCC papers give oncology teams, patients, policymakers and managers an overview of the elements needed in any healthcare system to provide high quality of care throughout the patient journey...
February 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29440666/folic-acid-exposure-rescues-spina-bifida-aperta-phenotypes-in-human-induced-pluripotent-stem-cell-model
#11
Vardine Sahakyan, Robin Duelen, Wai Long Tam, Scott J Roberts, Hanne Grosemans, Pieter Berckmans, Gabriele Ceccarelli, Gloria Pelizzo, Vania Broccoli, Jan Deprest, Frank P Luyten, Catherine M Verfaillie, Maurilio Sampaolesi
Neural tube defects (NTDs) are severe congenital abnormalities, caused by failed closure of neural tube during early embryonic development. Periconceptional folic acid (FA) supplementation greatly reduces the risk of NTDs. However, the molecular mechanisms behind NTDs and the preventive role of FA remain unclear. Here, we use human induced pluripotent stem cells (iPSCs) derived from fetuses with spina bifida aperta (SBA) to study the pathophysiology of NTDs and explore the effects of FA exposure. We report that FA exposure in SBA model is necessary for the proper formation and maturation of neural tube structures and robust differentiation of mesodermal derivatives...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29416527/the-impact-of-type-2-diabetes-on-bone-fracture-healing
#12
REVIEW
Carlos Marin, Frank P Luyten, Bart Van der Schueren, Greet Kerckhofs, Katleen Vandamme
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease known by the presence of elevated blood glucose levels. Nowadays, it is perceived as a worldwide epidemic, with a very high socioeconomic impact on public health. Many are the complications caused by this chronic disorder, including a negative impact on the cardiovascular system, kidneys, eyes, muscle, blood vessels, and nervous system. Recently, there has been increasing evidence suggesting that T2DM also adversely affects the skeletal system, causing detrimental bone effects such as bone quality deterioration, loss of bone strength, increased fracture risk, and impaired bone healing...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29405241/productivity-estimation-in-economic-evaluations-of-occupational-health-and-safety-interventions-a-systematic-review
#13
Jonas Steel, Lode Godderis, Jeroen Luyten
Objectives Occupational health and safety (OHS) interventions` effect on worker productivity is an essential, but complex element of the value of these programs. The trustworthiness of economic evaluation studies, aiming to provide guidance to decision-makers in the field of OHS, depends at least partly on how accurately productivity changes are measured. We aim to review the methods used to estimate productivity changes in recently published economic evaluations of OHS interventions. Methods We performed systematic searches of economic evaluations of OHS programs published between 2007 and 2017 and reviewed these studies` methods to quantify the programs` impact on worker productivity Results Of the 90 identified studies, 44 used a human capital approach, 17 a friction cost approach, 13 stated productivity in natural units (eg, a cost-per-absence-day-avoided), 7 made use of compensation expenses, 4 used output-based methods, 4 an "ad hoc" approach, and 1 study did not state its method...
February 6, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29395750/cost-effectiveness-of-ovarian-stimulation-with-gonadotrophin-and-clomiphene-citrate-in-an-intrauterine-insemination-programme-for-subfertile-couples
#14
Karen Peeraer, Jeroen Luyten, Carla Tomassetti, Sarah Verschueren, Carl Spiessens, Ann Tanghe, Christel Meuleman, Sophie Debrock, Eline Dancet, Thomas D'Hooghe
Ovarian stimulation with low-dose human menopausal gonadotrophin (HMG) is superior to clomiphene citrate in intrauterine insemination (IUI) cycles with respect to clinical pregnancy rate, but it is unclear whether HMG is also the more cost-effective option. The aim of this study was to compare the cost-effectiveness of ovarian stimulation with low-dose subcutaneously administred HMG (37.5-75 IU per day) to orally administred clomiphene citrate (50 mg/day from day 3-7) in an IUI programme for subfertile couples...
December 27, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29380706/anticancer-activity-study-of-chromone-and-coumarin-hybrids-using-electrical-impedance-spectroscopy
#15
Mustapha M Bouhenna, Monica Vara Perez, Oualid Talhi, Khaldoun Bachari, Artur M S Silva, Walter Luyten, Nabil Mameri
Oncology treatments aim at selective toxicity for tumor (compared to normal) cells, and chromone-coumarin hybrids have shown such activity. In this study, we test a novel series of synthetic chromone and coumarin derivatives (1-9) for cytotoxic activity against a panel of tumor cell lines (MCF-7, A549, HepG2, HTC-116, B16) opposed to non-tumor cells (Caco-2 and HEK-293t). Electrical impedance spectroscopy was used to monitor cell viability in real time. Compound 8 showed the most potent activity, and it significantly diminished cancer cell proliferation and viability in different cell lines...
January 29, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29366765/active-principles-of-tetradenia-riparia-iv-anthelmintic-activity-of-8-14-15-sandaracopimaradiene-7%C3%AE-18-diol
#16
Luc Van Puyvelde, Maoxuan Liu, Cedrick Veryser, Wim M De Borggraeve, Joseph Mungarulire, Marie Jeanne Mukazayire, Walter Luyten
ETHNOPHARMACOLOGICAL RELEVANCE: Tetradenia (T.) riparia (Hochst.) Codd (Lamiaceae), formerly known as Iboza riparia (Hochst.) N.E.Br., is one of the most frequently used medicinal plants in traditional Rwandese medicine. It was used as a remedy against a wide range of diseases including malaria, angina, yaws, dental abscesses, headache, worm infections and several kinds of fevers and aches. AIM OF THE STUDY: This study aims to identify the compounds active against helminths from Tetradenia riparia...
April 24, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29338133/pimasertib-associated-ophthalmological-adverse-events
#17
Elon H C van Dijk, Wim H J Kruit, Martine J Jager, Gregorius P M Luyten, Johannes R Vingerling, Camiel J F Boon
PURPOSE: To analyse ophthalmological adverse events associated with mitogen-activated protein kinase kinase (MEK) inhibition with pimasertib treatment for metastatic cutaneous melanoma (CM). METHODS: In this prospective observational, cohort-based, cross-sectional study, eight patients treated with the MEK inhibitor pimasertib received a complete ophthalmic examination. This included Early Treatment of Diabetic Retinopathy Study best-corrected visual acuity, visual field testing, colour vision testing, slit-lamp examination, applanation tonometry, indirect ophthalmoscopy, digital colour fundus photography and optical coherence tomography (OCT)...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29335516/an-evaluation-of-the-effect-of-pulse-shape-on-grey-and-white-matter-stimulation-in-the-rat-brain
#18
Marjolijn Deprez, Kelly Luyck, Laura Luyten, Tim Tambuyzer, Bart Nuttin, Myles Mc Laughlin
Despite the current success of neuromodulation, standard biphasic, rectangular pulse shapes may not be optimal to achieve symptom alleviation. Here, we compared stimulation efficiency (in terms of charge) between complex and standard pulses in two areas of the rat brain. In motor cortex, Gaussian and interphase gap stimulation (IPG) increased stimulation efficiency in terms of charge per phase compared with a standard pulse. Moreover, IPG stimulation of the deep mesencephalic reticular formation in freely moving rats was more efficient compared to a standard pulse...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29313045/thermal-stability-of-trihexyl-tetradecyl-phosphonium-chloride
#19
Clio Deferm, Arne Van den Bossche, Jan Luyten, Harald Oosterhof, Jan Fransaer, Koen Binnemans
Dynamic TGA studies of phosphonium ionic liquids have reported thermal stabilities of 300 °C or higher for these compounds. This is often an overestimation of the real thermal stability. The chosen technique as well as the experimental parameters can influence the thermal stability. In this paper, the thermal stability of commercially available Cyphos IL 101 is studied. The effect of the nature of the atmosphere (air or inert gas), the purity of the sample, the heating rate and presence of a metal on the short-term and long-term stability of commercial Cyphos IL 101 is investigated...
January 24, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29306094/simultaneous-three-dimensional-visualization-of-mineralized-and-soft-skeletal-tissues-by-a-novel-microct-contrast-agent-with-polyoxometalate-structure
#20
Greet Kerckhofs, Steve Stegen, Nick van Gastel, Annelies Sap, Guillaume Falgayrac, Guillaume Penel, Marjorie Durand, Frank P Luyten, Liesbet Geris, Katleen Vandamme, Tatjana Parac-Vogt, Geert Carmeliet
Biological tissues have a complex and heterogeneous 3D structure, which is only partially revealed by standard histomorphometry in 2D. We here present a novel chemical compound for contrast-enhanced microfocus computed tomography (CE-CT), a Hafnium-based Wells-Dawson polyoxometalate (Hf-POM), which allows simultaneous 3D visualization of mineralized and non-mineralized skeletal tissues, such as mineralized bone and bone marrow vasculature and adipocytes. We validated the novel contrast agent, which has a neutral pH in solution, by detailed comparison with (immuno)histology on murine long bones as blueprint, and showed that Hf-POM-based CE-CT can be used for virtual 3D histology...
March 2018: Biomaterials
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