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https://www.readbyqxmd.com/read/29179875/surgical-staging-identified-false-hpv-negative-cases-in-a-large-series-of-invasive-cervical-cancers
#1
Karl Ulrich Petry, Clemens Liebrich, Alexander Luyten, Martina Zander, Thomas Iftner
OBJECTIVE: We examined a large series of biopsy-proven invasive cervical cancers with surgical staging and HPV re-testing to estimate the relevance of HPV-negative cervical cancers in a Caucasian population. METHODS: We prospectively collected smears from 371 patients with a biopsy-proven diagnosis of cervical cancer for HC2 testing of high-risk HPV (HR-HPV). In HC2-negative cases, smears and paraffin embedded tissue blocks underwent additional HPV genotyping. RESULTS: HC2 tests showed 31/371 cases (8...
December 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/29122824/ruthenium-106-brachytherapy-for-iris-and-iridociliary-melanomas
#2
Marina Marinkovic, Nanda Horeweg, Mirjam S Laman, Jaco C Bleeker, Martijn Ketelaars, Femke P Peters, Gre P M Luyten, Carien L Creutzberg
BACKGROUND AND PURPOSE: To evaluate ruthenium-106 (Ru106) brachytherapy as eye-conserving treatment of iris melanomas (IMs) and iridociliary melanomas (ICMs). MATERIALS AND METHODS: Eighty-eight patients received Ru106 brachytherapy between 2006 and 2016. Primary outcome was local control, and secondary outcomes were metastasis, survival, eye preservation, complications and visual acuity (VA). RESULTS: Overall median follow-up was 36 months...
November 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29122819/treatment-of-conjunctival-melanoma-in-a-dutch-referral-centre
#3
Niels J Brouwer, Marina Marinkovic, Sjoerd G van Duinen, Jaco C Bleeker, Martine J Jager, Gregorius P M Luyten
AIMS: To evaluate the treatment of conjunctival melanoma at a large Dutch referral centre and to make recommendations for clinical management. METHODS: A retrospective review was performed of clinical and histological data of 70 patients treated for a primary conjunctival melanoma between 2001 and 2014 at the Leiden University Medical Center, Leiden, the Netherlands. Detailed follow-up data were available for all patients. RESULTS: The mean follow-up time was 70...
November 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29109684/antimicrobial-anthelmintic-and-antiviral-activity-of-plants-traditionally-used-for-treating-infectious-disease-in-the-similipal-biosphere-reserve-odisha-india
#4
Sujogya K Panda, Laxmipriya Padhi, Pieter Leyssen, Maoxuan Liu, Johan Neyts, Walter Luyten
In the present study, we tested in vitro different parts of 35 plants used by tribals of the Similipal Biosphere Reserve (SBR, Mayurbhanj district, India) for the management of infections. From each plant, three extracts were prepared with different solvents (water, ethanol, and acetone) and tested for antimicrobial (E. coli, S. aureus, C. albicans); anthelmintic (C. elegans); and antiviral (enterovirus 71) bioactivity. In total, 35 plant species belonging to 21 families were recorded from tribes of the SBR and periphery...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29107398/the-stress-reward-mentalizing-model-of-depression-an-integrative-developmental-cascade-approach-to-child-and-adolescent-depressive-disorder-based-on-the-research-domain-criteria-rdoc-approach
#5
REVIEW
Patrick Luyten, Peter Fonagy
The Research Domain Criteria (RDoC) propose a much-needed change in approach to the study of vulnerability factors implicated in mental disorders, shifting away from a categorical, disease-oriented model to a dimensional approach that focuses on underlying systems implicated in psychopathology. In this paper we illustrate this approach with a focus on the emergence of depression in childhood and adolescence. Based on evolutionary biological and developmental psychopathology considerations, we present an integrative developmental cascade model of depression that essentially suggests that depression emerges out of a three-pronged series of interacting impairments in the domains of stress regulation, reward, and mentalizing...
October 9, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/29057596/the-anaclitic-introjective-depression-assessment-development-and-preliminary-validity-of-an-observer-rated-measure
#6
Felicitas Rost, Patrick Luyten, Peter Fonagy
BACKGROUND: The two-configurations model developed by Blatt and colleagues offers a comprehensive conceptual and empirical framework for understanding depression. This model suggests that depressed patients struggle, at different developmental levels, with issues related to dependency (anaclitic issues) or self-definition (introjective issues), or a combination of both. AIMS: This paper reports three studies on the development and preliminary validation of the Anaclitic-Introjective Depression Assessment, an observer-rated assessment tool of impairments in relatedness and self-definition in clinical depression based on the item pool of the Shedler-Westen Assessment Procedure...
October 23, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/29037109/the-process-of-co-creating-the-interface-for-venster-an-interactive-artwork-for-nursing-home-residents-with-dementia
#7
Gaston Jamin, Tom Luyten, Rob Delsing, Susy Braun
INTRODUCTION: Interactive art installations might engage nursing home residents with dementia. The main aim of this article was to describe the challenging design process of an interactive artwork for nursing home residents, in co-creation with all stakeholders and to share the used methods and lessons learned. This process is illustrated by the design of the interface of VENSTER as a case. METHODS: Nursing home residents from the psychogeriatric ward, informal caregivers, client representatives, health care professionals and members of the management team were involved in the design process, which consisted of three phases: (1) identify requirements, (2) develop a prototype and (3) conduct usability tests...
October 17, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29031184/gene-environment-interactions-between-stress-and-5-httlpr-in-depression-a-meta-analytic-update
#8
REVIEW
Dries Bleys, Patrick Luyten, Bart Soenens, Stephan Claes
BACKGROUND: Meta-analyses have yielded contradictory findings concerning the role of 5-HTTLPR in interaction with stress (GxE) in depression. The current meta-analysis investigates if these contradictory findings are a result of differences between studies in methodological approaches towards the assessment of stress and depression. METHODS: After performing a systematic database search (February to December 2016), first, a meta-analysis was used to investigate the total effect size and publication bias...
October 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29024891/mentalizing-and-interpersonal-problems-in-borderline-personality-disorder-the-mediating-role-of-identity-diffusion
#9
Celine De Meulemeester, Benedicte Lowyck, Rudi Vermote, Yannic Verhaest, Patrick Luyten
Individuals with borderline personality disorder (BPD) are characterized by problems in interpersonal functioning and their long-term social integration often remains problematic. Extant theories have linked identity diffusion to many of the interpersonal problems characteristic of BPD patients. Recent theoretical accounts have suggested that identity diffusion results from problems with mentalizing or reflective functioning, that is, the capacity to understand oneself and others in terms of intentional mental states...
December 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28993161/new-class-of-early-stage-enterovirus-inhibitors-with-a-novel-mechanism-of-action
#10
Yipeng Ma, Rana Abdelnabi, Leen Delang, Mathy Froeyen, Walter Luyten, Johan Neyts, Carmen Mirabelli
4-dimethylamino benzoic acid (compound 12, synonym: 4EDMAB) was identified as an in vitro inhibitor of Coxsackie virus B3 (CVB3) replication in CPE-based assays (EC50 of 9.1 ± 1.5 μM). Next, the activity of twenty-three analogues was assessed, their structure-activity relationship was deduced and a more potent analogue was identified (EC50 of 2.6 ± 0.5 μM). The antiviral activity of 4EDMAB was further confirmed by quantifying viral RNA yield. Time-of-drug-addition assay revealed that 4EDMAB exerts its antiviral activity at the early stages of virus replication...
October 7, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28987025/an-integrated-bioprocess-for-the-expansion-and-chondrogenic-priming-of-human-periosteum-derived-progenitor-cells-in-suspension-bioreactors
#11
Priyanka Gupta, Liesbet Geris, Frank P Luyten, Ioannis Papantoniou
The increasing use of microcarrier based suspension bioreactors for scalable expansion of adult progenitor cells in recent years reveals the necessity of such approaches to address bio manufacturing challenges of advanced therapeutic medicinal products. However, the differentiation of progenitor cells within suspension bioreactors for the production of tissue modules is of equal importance but not well investigated. This study reports on the development of a bioreactor based integrated process for expansion and chondrogenic priming of human periosteum derived stem cells (hPDCs) using Cultispher S microcarriers...
October 7, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28985628/a-mentalization-based-approach-to-common-factors-in-the-treatment-of-borderline-personality-disorder
#12
REVIEW
Anthony Bateman, Chloe Campbell, Patrick Luyten, Peter Fonagy
In this paper we conceptualize borderline personality disorder as a disorder of mentalizing, social cognition, and loss of resilience. Several treatment approaches are effective, and meta-analyses suggest that there are few substantive differences in effectiveness between them and between specialized and non-specialized approaches. We propose that these findings arise because of shared mechanisms of change, congruent with current thinking both about the existence of a general 'p' factor of psychopathology and a reconceptualization of personality disorders as involving a lack of resilience resulting from problems with epistemic trust and salutogenesis, the capacity to derive benefit from the social environment...
September 14, 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28985489/changes-in-gait-characteristics-of-women-with-early-and-established-medial-knee-osteoarthritis-results-from-a-2-years-longitudinal-study
#13
Armaghan Mahmoudian, Jaap H van Dieёn, Isabel A C Baert, Sjoerd M Bruijn, Gert S Faber, Frank P Luyten, Sabine M P Verschueren
BACKGROUND: Despite the large number of cross-sectional studies on gait in subjects with knee osteoarthritis, there are scarcely any longitudinal studies on gait changes in knee osteoarthritis. METHODS: Gait analysis was performed on 25 women with early and 18 with established medial knee osteoarthritis, as well as a group of 23 healthy controls. Subjects were asked to walk at their comfortable speed. Kinematic and kinetic data were measured at baseline and after 2years follow-up...
October 2, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28968563/changes-in-interpersonal-problems-in-the-psychotherapeutic-treatment-of-depression-as-measured-by-the-inventory-of-interpersonal-problems-a-systematic-review-and-meta-analysis
#14
REVIEW
Tara McFarquhar, Patrick Luyten, Peter Fonagy
BACKGROUND: Interpersonal problems are commonly reported by depressed patients, but the effect of psychotherapeutic treatment on them remains unclear. This paper reviews the effectiveness of psychotherapeutic interventions for depression on interpersonal problems as measured by the Inventory of Interpersonal Problems (IIP). METHODS: An electronic database search identified articles reporting IIP outcome scores for individual adult psychotherapy for depression. A systematic review and, where possible, meta-analysis was conducted...
January 15, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28961665/bias-toward-psychodynamic-therapy-framing-the-problem-and-working-toward-a-solution
#15
Allan Abbass, Patrick Luyten, Christiane Steinert, Falk Leichsenring
Although psychodynamic therapy (PDT) is an evidence-based intervention for a broad spectrum of psychiatric conditions, there is often notable bias in the way PDT is depicted both in the popular media and in the scientific literature. This has contributed to a negative view of PDT, which hampers both patient access to this treatment and researcher access to funding for further research on PDT. The adverse effects of these distortions and biases are detrimental not only to PDT but also to the overall field of psychotherapy, raising questions about its credibility...
September 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28947760/two-genomes-of-highly-polyphagous-lepidopteran-pests-spodoptera-frugiperda-noctuidae-with-different-host-plant-ranges
#16
Anaïs Gouin, Anthony Bretaudeau, Kiwoong Nam, Sylvie Gimenez, Jean-Marc Aury, Bernard Duvic, Frédérique Hilliou, Nicolas Durand, Nicolas Montagné, Isabelle Darboux, Suyog Kuwar, Thomas Chertemps, David Siaussat, Anne Bretschneider, Yves Moné, Seung-Joon Ahn, Sabine Hänniger, Anne-Sophie Gosselin Grenet, David Neunemann, Florian Maumus, Isabelle Luyten, Karine Labadie, Wei Xu, Fotini Koutroumpa, Jean-Michel Escoubas, Angel Llopis, Martine Maïbèche-Coisne, Fanny Salasc, Archana Tomar, Alisha R Anderson, Sher Afzal Khan, Pascaline Dumas, Marion Orsucci, Julie Guy, Caroline Belser, Adriana Alberti, Benjamin Noel, Arnaud Couloux, Jonathan Mercier, Sabine Nidelet, Emeric Dubois, Nai-Yong Liu, Isabelle Boulogne, Olivier Mirabeau, Gaelle Le Goff, Karl Gordon, John Oakeshott, Fernando L Consoli, Anne-Nathalie Volkoff, Howard W Fescemyer, James H Marden, Dawn S Luthe, Salvador Herrero, David G Heckel, Patrick Wincker, Gael J Kergoat, Joelle Amselem, Hadi Quesneville, Astrid T Groot, Emmanuelle Jacquin-Joly, Nicolas Nègre, Claire Lemaitre, Fabrice Legeai, Emmanuelle d'Alençon, Philippe Fournier
Emergence of polyphagous herbivorous insects entails significant adaptation to recognize, detoxify and digest a variety of host-plants. Despite of its biological and practical importance - since insects eat 20% of crops - no exhaustive analysis of gene repertoires required for adaptations in generalist insect herbivores has previously been performed. The noctuid moth Spodoptera frugiperda ranks as one of the world's worst agricultural pests. This insect is polyphagous while the majority of other lepidopteran herbivores are specialist...
September 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28945785/signaling-properties-of-the-human-chemokine-receptors-cxcr4-and-cxcr7-by-cellular-electric-impedance-measurements
#17
Jordi Doijen, Tom Van Loy, Wouter De Haes, Bart Landuyt, Walter Luyten, Liliane Schoofs, Dominique Schols
The chemokine receptor 4 (CXCR4) and 7 (CXCR7) are G-protein-coupled receptors involved in various diseases including human cancer. As such, they have become important targets for therapeutic intervention. Cell-based receptor assays, able to detect agents that modulate receptor activity, are of key importance for drug discovery. We evaluated the potential of cellular electric impedance for this purpose. Dose-dependent and specific stimulation of CXCR4 was detected upon addition of its unique chemokine ligand CXCL12...
2017: PloS One
https://www.readbyqxmd.com/read/28939390/exploring-parental-mentalization-in-postnatal-phase-with-a-self-report-questionnaire-prfq-factor-structure-gender-differences-and-association-with-sociodemographic-factors-the-finn-brain-birth-cohort-study
#18
Marjukka Pajulo, Mimmi Tolvanen, Nina Pyykkönen, Linnea Karlsson, Linda Mayes, Hasse Karlsson
The objective was to explore the preliminary functioning of a self-report questionnaire designed to assess parental reflective functioning (PRFQ, Luyten et al., 2009, unpublished manual) during early postnatal phase and with a large population-based sample. Parental reflective functioning (PRF) refers to parental capacity to focus on experience and feelings, within self, in the child and underlying observed reactions. Individual differences in PRF reportedly affect child attachment and socio-emotional development...
September 11, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28935341/conduct-problems-in-youth-and-the-rdoc-approach-a-developmental-evolutionary-based-view
#19
REVIEW
Peter Fonagy, Patrick Luyten
Problems related to aggression in young people are traditionally subsumed under the header of conduct problems, which include conduct disorder and oppositional defiant disorder. Such problems in children and adolescents are an important societal and mental health problem. In this paper we present an evolutionarily informed developmental psychopathology view of conduct problems inspired by the NIMH Research Domain Criteria (RDoC) initiative. We assume that while there are many pathways to conduct problems, chronic or temporary impairments in the domain of social cognition or mentalizing are a common denominator...
September 8, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28919106/selecting-relevant-features-from-the-electronic-health-record-for-clinical-code-prediction
#20
Elyne Scheurwegs, Boris Cule, Kim Luyckx, Léon Luyten, Walter Daelemans
A multitude of information sources is present in the electronic health record (EHR), each of which can contain clues to automatically assign diagnosis and procedure codes. These sources however show information overlap and quality differences, which complicates the retrieval of these clues. Through feature selection, a denser representation with a consistent quality and less information overlap can be obtained. We introduce and compare coverage-based feature selection methods, based on confidence and information gain...
October 2017: Journal of Biomedical Informatics
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