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https://www.readbyqxmd.com/read/28417664/low-dose-systemic-scopolamine-disrupts-context-conditioning-in-rats
#1
Laura Luyten, Shauni Nuyts, Tom Beckers
Cholinergic neurotransmission plays a key role in learning and memory. Prior research with rats indicated that a low dose of pre-training scopolamine (0.1 mg/kg), a cholinergic receptor antagonist, did not affect cued fear conditioning, but did block renewal when injected before extinguishing a conditioned tone, opening up opportunities to pharmacologically improve exposure therapy for anxiety patients. Before translating these findings to the clinic, it is important to carefully examine how scopolamine affects contextual fear memories...
April 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28413687/what-we-have-changed-our-minds-about-part-1-borderline-personality-disorder-as-a-limitation-of-resilience
#2
REVIEW
Peter Fonagy, Patrick Luyten, Elizabeth Allison, Chloe Campbell
This paper sets out a recent transition in our thinking in relation to psychopathology associated with personality disorder, in an approach that integrates our thinking about attachment, mentalizing (understanding ourselves and others in terms of intentional mental states) and epistemic trust (openness to the reception of social communication that is personally relevant and of generalizable significance) with recent findings on the structure of both adult and child psychopathology and resilience. In this paper - the first of two parts - we review evidence suggesting that a general psychopathology or p factor underlies vulnerability for psychopathology...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/28405338/what-we-have-changed-our-minds-about-part-2-borderline-personality-disorder-epistemic-trust-and-the-developmental-significance-of-social-communication
#3
REVIEW
Peter Fonagy, Patrick Luyten, Elizabeth Allison, Chloe Campbell
In Part 1 of this paper, we discussed emerging evidence suggesting that a general psychopathology or 'p' factor underlying the various forms of psychopathology should be conceptualized in terms of the absence of resilience, that is, the absence of positive reappraisal mechanisms when faced with adversity. These impairments in the capacity for positive reappraisal seem to provide a comprehensive explanation for the association between the p factor and comorbidity, future caseness, and the 'hard-to-reach' character of many patients with severe personality pathology, most notably borderline personality disorder (BPD)...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/28400312/assigning-clinical-codes-with-data-driven-concept-representation-on-dutch-clinical-free-text
#4
Elyne Scheurwegs, Kim Luyckx, Léon Luyten, Bart Goethals, Walter Daelemans
Clinical codes are used for public reporting purposes, are fundamental to determining public financing for hospitals, and form the basis for reimbursement claims to insurance providers. They are assigned to a patient stay to reflect the diagnosis and performed procedures during that stay. This paper aims to enrich algorithms for automated clinical coding by taking a data-driven approach and by using unsupervised and semi-supervised techniques for the extraction of multi-word expressions that convey a generalisable medical meaning (referred to as concepts)...
April 8, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28393091/data-on-cytotoxicity-in-hela-and-su-dhl-4-cells-exposed-to-dpb162-ae-compound
#5
Mart Bittremieux, Katsuhiko Mikoshiba, Geert Bultynck
DPB162-AE is a valuable tool to study store-operated Ca(2+) entry (SOCE), as this compound was developed as a 2-APB analog that inhibits SOCE more potently and more selectively than 2-APB itself. In addition to this, we showed that, in some conditions, DPB162-AE can deplete the endoplasmic reticulum Ca(2+) stores in intact cells, including the cervical carcinoma HeLa cell line and the diffuse large B-cell lymphoma SU-DHL-4 cell line. Here, we present data regarding the toxicity of DPB162-AE in HeLa and SU-DHL-4 cells...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28391358/genetic-evolution-of-uveal-melanoma-guides-the-development-of-an-inflammatory-microenvironment
#6
Gülçin Gezgin, Mehmet Dogrusöz, T Huibertus van Essen, Wilhelmina G M Kroes, Gregorius P M Luyten, Pieter A van der Velden, Vonn Walter, Robert M Verdijk, Thorbald van Hall, Sjoerd H van der Burg, Martine J Jager
Uveal melanoma (UM) is characterized by a number of genetic aberrations that follow a certain chronology and are tightly linked to tumor recurrence and survival. Loss of chromosome 3, bi-allelic loss of BAP1 expression, and gain in chromosome 8q have been associated with metastasis formation and death, while loss of chromosome 3 has been associated with the influx of macrophages and T cells. We used a set of genetically-classified UM to study immune infiltration in the context of their genetic evolution. We show in two independent cohorts that lack of BAP1 expression is associated with an increased density of CD3(+) T cells and CD8(+) T cells...
April 8, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28338421/harnessing-the-osteogenicity-of-in-vitro-stem-cell-derived-mineralized-extracellular-matrix-as-3d-biotemplate-to-guide-bone-regeneration
#7
Yoke Chin Chai, Johanna Bolander, Ioannis Papantoniou, Jennifer Patterson, Jef Vleugels, Jan Schrooten, Frank P Luyten
Advanced biomaterials that are capable of guiding robust bone regeneration are highly demanded for translational therapy of bone defects or bone augmentation in clinics. One of the strategic approaches is to produce tissue engineering (TE) constructs that mediate bone regeneration by recapitulating the natural bone formation or healing process. In this study, we aimed at producing devitalized mineralized carriers with augmented bone forming capacity via a modified culture protocol (i.e., culture conditions with high calcium and/or phosphate concentrations) that first promotes cell growth and, subsequently, mineralized extracellular matrix (ECM) deposition by human periosteum-derived osteoprogenitor cells (hPDCs) on additive manufactured three-dimensional (3D) porous titanium (Ti)-based scaffolds...
March 24, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28294262/speciation-of-indium-iii-chloro-complexes-in-the-solvent-extraction-process-from-chloride-aqueous-solutions-to-ionic-liquids
#8
Clio Deferm, Bieke Onghena, Tom Vander Hoogerstraete, Dipanjan Banerjee, Jan Luyten, Harald Oosterhof, Jan Fransaer, Koen Binnemans
Most metal extraction studies focus on the kinetics, the maximum loading and the extraction equilibrium, while structural information on the extracted complexes has been limited. This paper concerns the nature of the indium(iii) chloride complexes, present in the organic and aqueous phase during the solvent extraction of indium(iii) from an aqueous HCl solution by undiluted ionic liquids Cyphos(®) IL 101 and Aliquat(®) 336. In an aqueous HCl solution (0-12 M), indium(iii) exists as octahedral mixed complexes, [In(H2O)6-nCln](3-n) (0 ≤ n ≤ 6)...
March 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28287047/how-nursing-home-residents-with-dementia-respond-to-the-interactive-art-installation-venster-a-pilot-study
#9
Tom Luyten, Susy Braun, Gaston Jamin, Susan van Hooren, Luc de Witte
The goal of this study was (1) to determine whether and how nursing home residents with dementia respond to the interactive art installation in general and (2) to identify whether responses change when the content type and, therefore, the nature of the interaction with the artwork changes. The interactive art installation 'VENSTER' evokes responses in nursing home residents with dementia, illustrating the potential of interactive artworks in the nursing home environment. Frequently observed responses were naming, recognizing or asking questions about depicted content and how the installation worked, physically gesturing towards or tapping on the screen and tapping or singing along to the music...
March 12, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28263091/attachment-and-reflective-functioning-in-women-with-borderline-personality-disorder
#10
Deborah Badoud, Paco Prada, Rosetta Nicastro, Charlotte Germond, Patrick Luyten, Nader Perroud, Martin Debbané
Insecure attachment and impairments in reflective functioning (RF) are thought to play a critical role in borderline personality disorder (BPD). In particular, the mentalization-based model argues that insecure attachment indirectly accounts for increased BPD features, notably via disruption of RF capacities. Although the mediation relationship between attachment, RF, and BPD is supported by previous evidence, it remains to be directly tested in adults with BPD. In the current study, a sample of 55 female adult BPD patients and 105 female healthy controls completed a battery of self-report measures to investigate the interplay between attachment, RF capacities, and BPD clinical status...
March 6, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28256778/rechargeable-stimulators-in-deep-brain-stimulation-for-obsessive-compulsive-disorder-a-prospective-interventional-cohort-study
#11
Philippe De Vloo, Simon Raymaekers, Kris van Kuyck, Laura Luyten, Lutgardis Gabriëls, Bart Nuttin
BACKGROUND: From 1999 onwards, deep brain stimulation (DBS) has been proposed as an alternative to capsulotomy in refractory cases of obsessive-compulsive disorder (OCD). Although rechargeable implantable pulse generators (rIPGs) have been used extensively in DBS for movement disorders, there are no reports on rIPGs in patients with a psychiatric DBS indication, and even possible objections to their use. OBJECTIVE: We aim to evaluate rIPGs in OCD in terms of effectiveness, applicability, safety, and need for IPG replacement...
March 3, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28254579/resveratrol-induced-autophagy-is-dependent-on-ip3rs-and-on-cytosolic-ca-2
#12
Tomas Luyten, Kirsten Welkenhuyzen, Gemma Roest, Elzbieta Kania, Liwei Wang, Mart Bittremieux, David I Yule, Jan B Parys, Geert Bultynck
Previous work revealed that intracellular Ca(2+) signals and the inositol 1,4,5-trisphosphate (IP3) receptors (IP3R) are essential to increase autophagic flux in response to mTOR inhibition, induced by either nutrient starvation or rapamycin treatment. Here, we investigated whether autophagy induced by resveratrol, a polyphenolic phytochemical reported to trigger autophagy in a non-canonical way, also requires IP3Rs and Ca(2+) signaling. Resveratrol augmented autophagic flux in a time-dependent manner in HeLa cells...
February 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28249080/treating-borderline-personality-disorder-with-psychotherapy-where-do-we-go-from-here
#13
Peter Fonagy, Patrick Luyten, Anthony Bateman
No abstract text is available yet for this article.
April 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28196740/dpb162-ae-an-inhibitor-of-store-operated-ca-2-entry-can-deplete-the-endoplasmic-reticulum-ca-2-store
#14
Mart Bittremieux, Julia V Gerasimenko, Marleen Schuermans, Tomas Luyten, Eloise Stapleton, Kamil J Alzayady, Humbert De Smedt, David I Yule, Katsuhiko Mikoshiba, Peter Vangheluwe, Oleg V Gerasimenko, Jan B Parys, Geert Bultynck
Store-operated Ca(2+) entry (SOCE), an important Ca(2+) signaling pathway in non-excitable cells, regulates a variety of cellular functions. To study its physiological role, pharmacological tools, like 2-aminoethyl diphenylborinate (2-APB), are used to impact SOCE. 2-APB is one of the best characterized SOCE inhibitors. However, 2-APB also activates SOCE at lower concentrations, while it inhibits inositol 1,4,5-trisphosphate receptors (IP3Rs), sarco/endoplasmic reticulum Ca(2+)-ATPases (SERCAs) and other ion channels, like TRP channels...
February 1, 2017: Cell Calcium
https://www.readbyqxmd.com/read/28196691/healing-of-a-large-long-bone-defect-through-serum-free-in%C3%A2-vitro-priming-of%C3%A2-human-periosteum-derived-cells
#15
Johanna Bolander, Wei Ji, Jeroen Leijten, Liliana Moreira Teixeira, Veerle Bloemen, Dennis Lambrechts, Malay Chaklader, Frank P Luyten
Clinical translation of cell-based strategies for regenerative medicine demands predictable in vivo performance where the use of sera during in vitro preparation inherently limits the efficacy and reproducibility. Here, we present a bioinspired approach by serum-free pre-conditioning of human periosteum-derived cells, followed by their assembly into microaggregates simultaneously primed with bone morphogenetic protein 2 (BMP-2). Pre-conditioning resulted in a more potent progenitor cell population, while aggregation induced osteochondrogenic differentiation, further enhanced by BMP-2 stimulation...
March 14, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28195571/electrical-stimulation-of-the-bed-nucleus-of-the-stria-terminalis-reduces-anxiety-in-a-rat-model
#16
K Luyck, T Tambuyzer, M Deprez, J Rangarajan, B Nuttin, L Luyten
We recently showed that deep brain stimulation (DBS) in the bed nucleus of the stria terminalis (BST) reduces obsessions, compulsions and associated anxiety in patients suffering from severe, treatment-refractory obsessive-compulsive disorder. Here, we investigated the anxiolytic effects of electrical BST stimulation in a rat model of conditioned anxiety, unrelated to obsessions or compulsions. Two sets of stimulation parameters were evaluated. Using fixed settings at 100 Hz, 40 μs and 300 μA (Set A), we observed elevated freezing and startle levels, whereas stimulation at 130 Hz, 220 μs and individually tailored amplitudes (Set B) appeared to reduce freezing...
February 14, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28180279/dna-target-recognition-domains-in-the-type-i-restriction-and-modification-systems-of-staphylococcus-aureus
#17
Laurie P Cooper, Gareth A Roberts, John H White, Yvette A Luyten, Edward K M Bower, Richard D Morgan, Richard J Roberts, Jodi A Lindsay, David T F Dryden
Staphylococcus aureus displays a clonal population structure in which horizontal gene transfer between different lineages is extremely rare. This is due, in part, to the presence of a Type I DNA restriction-modification (RM) system given the generic name of Sau1, which maintains different patterns of methylation on specific target sequences on the genomes of different lineages. We have determined the target sequences recognized by the Sau1 Type I RM systems present in a wide range of the most prevalent S. aureus lineages and assigned the sequences recognized to particular target recognition domains within the RM enzymes...
April 7, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28179071/the-bh4-domain-of-bcl-2-orthologues-from-different-classes-of-vertebrates-can-act-as-an-evolutionary-conserved-inhibitor-of-ip3-receptor-channels
#18
Hristina Ivanova, Tomas Luyten, Elke Decrock, Tim Vervliet, Luc Leybaert, Jan B Parys, Geert Bultynck
Ca(2+) signalling plays an important role in various physiological processes in vertebrates. In mammals, the highly conserved anti-apoptotic B-cell lymphoma-2 (Bcl-2) protein is an important modulator of the inositol 1,4,5-trisphosphate receptor (IP3R), i.e. the main intracellular Ca(2+) - release channel located at the endoplasmic reticulum (ER). The Bcl-2 Homology (BH) 4 domain of Bcl-2 (BH4-Bcl-2) is a critical determinant for inhibiting IP3Rs, by directly targeting a region in the modulatory domain of the receptor (domain 3)...
January 25, 2017: Cell Calcium
https://www.readbyqxmd.com/read/28168598/brain-activity-underlying-negative-self-and-other-perception-in-adolescents-the-role-of-attachment-derived-self-representations
#19
Martin Debbané, Deborah Badoud, David Sander, Stephan Eliez, Patrick Luyten, Pascal Vrtička
One of teenagers' key developmental tasks is to engage in new and meaningful relationships with peers and adults outside the family context. Attachment-derived expectations about the self and others in terms of internal attachment working models have the potential to shape such social reorientation processes critically and thereby influence adolescents' social-emotional development and social integration. Because the neural underpinnings of this developmental task remain largely unknown, we sought to investigate them by functional magnetic resonance imaging...
February 6, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28159971/the-prognostic-value-of-ajcc-staging-in-uveal-melanoma-is-enhanced-by-adding-chromosome-3-and-8q-status
#20
Mehmet Dogrusöz, Mette Bagger, Sjoerd G van Duinen, Wilma G Kroes, Claudia A L Ruivenkamp, Stefan Böhringer, Klaus Kaae Andersen, Gregorius P M Luyten, Jens F Kiilgaard, Martine J Jager
Purpose: The American Joint Committee on Cancer (AJCC) staging system has been validated for use as a prognostic parameter in uveal melanoma (UM). We studied whether adding information regarding chromosome 3 and 8q status further enhances the prognostic value of this staging system. Methods: We retrospectively studied a cohort of 522 patients who had been treated for UM in two different centers between 1999 and 2015. The mean follow-up time was 47.7 months. Cumulative incidence curves were generated and regression analyses were performed for different combinations of AJCC staging and chromosome status...
February 1, 2017: Investigative Ophthalmology & Visual Science
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