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https://www.readbyqxmd.com/read/28089960/cohort-profile-the-environmental-influence-on-early-ageing-environage-a-birth-cohort-study
#1
Bram G Janssen, Narjes Madlhoum, Wilfried Gyselaers, Esmée Bijnens, Diana B Clemente, Bianca Cox, Janneke Hogervorst, Leen Luyten, Dries S Martens, Martien Peusens, Michelle Plusquin, Eline B Provost, Harry A Roels, Nelly D Saenen, Maria Tsamou, Annette Vriens, Ellen Winckelmans, Karen Vrijens, Tim S Nawrot
No abstract text is available yet for this article.
January 15, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28055257/updating-the-evidence-and-recommendations-for-short-term-psychodynamic-psychotherapy-in-the-treatment-of-major-depressive-disorder-in-adults
#2
Joel M Town, Allan Abbass, Ellen Driessen, Patrick Luyten, Priyanthy Weerasekera
No abstract text is available yet for this article.
January 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/27955715/biases-in-research-risk-factors-for-non-replicability-in-psychotherapy-and-pharmacotherapy-research
#3
F Leichsenring, A Abbass, M J Hilsenroth, F Leweke, P Luyten, J R Keefe, N Midgley, S Rabung, S Salzer, C Steinert
Replicability of findings is an essential prerequisite of research. For both basic and clinical research, however, low replicability of findings has recently been reported. Replicability may be affected by research biases not sufficiently controlled for by the existing research standards. Several biases such as researcher allegiance or selective reporting are well-known for affecting results. For psychotherapy and pharmacotherapy research, specific additional biases may affect outcome (e.g. therapist allegiance, therapist effects or impairments in treatment implementation)...
December 13, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27943559/assessing-anaclitic-and-introjective-characteristics-using-the-swap-200-q-sort-concurrent-validity-with-the-inventory-of-interpersonal-problems-circumplex-scales
#4
Racheli Miller, Mark Hilsenroth
: This investigation's goal was to assess the concurrent validity of the four scales of the Anaclitic and Introjective Depression Assessment (AIDA), a newly developed clinician-rated measure, and the Inventory of Interpersonal Problems Circumplex Scales (IIP-64). The AIDA is composed of Shedler-Westen Assessment Procedure items and is comprised of two primitive and two more mature scales of introjective and anaclitic personality types. Specific predictions of relationships were made and are discussed further in this paper...
December 12, 2016: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/27913204/the-selective-bcl-2-inhibitor-venetoclax-a-bh3-mimetic-does-not-dysregulate-intracellular-ca-2-signaling
#5
Tamara Vervloessem, Hristina Ivanova, Tomas Luyten, Jan B Parys, Geert Bultynck
Anti-apoptotic B cell-lymphoma-2 (Bcl-2) proteins are emerging as therapeutic targets in a variety of cancers for precision medicines, like the BH3-mimetic drug venetoclax (ABT-199), which antagonizes the hydrophobic cleft of Bcl-2. However, the impact of venetoclax on intracellular Ca(2+) homeostasis and dynamics in cell systems has not been characterized in detail. Here, we show that venetoclax did not affect Ca(2+)-transport systems from the endoplasmic reticulum (ER) in permeabilized cell systems. Venetoclax (1μM) did neither trigger Ca(2+) release by itself nor affect agonist-induced Ca(2+) release in a variety of intact cell models...
November 30, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27896515/outcome-after-sentinel-lymph-node-dissection-in-vulvar-cancer-a-subgroup-analysis-of-the-ago-care-1-study
#6
Rüdiger Klapdor, Peter Hillemanns, Linn Wölber, Julia Jückstock, Felix Hilpert, Nikolaus de Gregorio, Severine Iborra, Jalid Sehouli, Anika Habermann, Sophie Teresa Fürst, Hans Georg Strauß, Klaus Baumann, Falk Thiel, Alexander Mustea, Werner Meier, Philipp Harter, Pauline Wimberger, Lars Hanker, Barbara Schmalfeldt, Ulrich Canzler, Tanja Fehm, Alexander Luyten, Martin Hellriegel, Jens Kosse, Christoph Heiss, Peer Hantschmann, Peter Mallmann, Berno Tanner, Jacobus Pfisterer, Barbara Richter, Martin Jäger, Sven Mahner
PURPOSE: Analyzing the large patient cohort of the multicenter AGO-CaRE-1 study, we compared isolated sentinel lymph node dissection (SLND) with radical lymph node dissection (LND) of the groin in relation to recurrence rates and survival. METHODS: The AGO-CaRE-1 study retrospectively collected data on treatment patterns and follow-up of vulvar cancer patients [International Federation of Gynecology and Obstetrics (FIGO) stage ≥1B] treated at 29 gynecologic cancer centers between 1998 and 2008...
November 28, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27859970/barriers-for-guideline-adherence-in-knee-osteoarthritis-care-a-qualitative-study-from-the-patients-perspective
#7
David Spitaels, Patrik Vankrunkelsven, Jurgen Desfosses, Frank Luyten, Sabine Verschueren, Dieter Van Assche, Bert Aertgeerts, Rosella Hermens
RATIONALE, AIMS AND OBJECTIVES: Guidelines for patients with knee osteoarthritis (OA) are suboptimally implemented in clinical care. To improve guideline adherence, patients' perceived barriers and facilitators in current care were investigated. METHODS: Eleven patients with knee OA were extensively interviewed using a semistructured script based on quality indicators. Directed content analysis, within the framework of Grol and Wensing, was performed to describe barriers and facilitators in 6 domains: guideline, health care professional, patient, social environment, organization, and financial context...
November 14, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27852532/are-physiotherapists-adhering-to-quality-indicators-for-the-management-of-knee-osteoarthritis-an-observational-study
#8
David Spitaels, Rosella Hermens, Dieter Van Assche, Sabine Verschueren, Frank Luyten, Patrik Vankrunkelsven
BACKGROUND: Osteoarthritis (OA) is a common musculoskeletal condition that often leads to pain, stiffness and disability. Physiotherapy plays an important role in the management of knee OA, however we hypothesize discordance between physiotherapists' practice and existing guideline recommendations. OBJECTIVES: This study aimed to measure physiotherapists' guideline adherence for knee OA. Additionally, determinants for guideline adherence at the professional and organizational level were explored, to find clues for improvement...
October 26, 2016: Manual Therapy
https://www.readbyqxmd.com/read/27811476/factors-involved-in-vocal-fatigue-a-pilot-study
#9
Evelien D'haeseleer, Mara Behlau, Laura Bruneel, Iris Meerschman, Anke Luyten, Stien Lambrecht, Mauriceia Cassol, Paul Corthals, Maryna Kryshtopava, Floris L Wuyts, Sofie Claeys, Kristiane Van Lierde
OBJECTIVE: The purpose of this retrospective study was to determine the vocal characteristics of a treatment-seeking population with the primary complaint of vocal fatigue (VF). METHODS: Forty-three men (mean age 42 years, range 19-69) and 145 women (mean age 34 years, range 18-68) were included. None of the subjects had received voice therapy or previous laryngeal surgery. A questionnaire, laryngeal and perceptual evaluations, aerodynamic and acoustic parameters, and the Dysphonia Severity Index (DSI) were used to determine vocal characteristics...
November 4, 2016: Folia Phoniatrica et Logopaedica
https://www.readbyqxmd.com/read/27808102/bioinspired-seeding-of-biomaterials-using-three-dimensional-microtissues-induces-chondrogenic-stem-cell-differentiation-and-cartilage-formation-under-growth-factor-free-conditions
#10
J Leijten, L S Moreira Teixeira, J Bolander, W Ji, B Vanspauwen, J Lammertyn, J Schrooten, F P Luyten
Cell laden biomaterials are archetypically seeded with individual cells and steered into the desired behavior using exogenous stimuli to control growth and differentiation. In contrast, direct cell-cell contact is instructive and even essential for natural tissue formation. Namely, microaggregation and condensation of mesenchymal progenitor cells triggers chondrogenesis and thereby drives limb formation. Yet a biomimetic strategy translating this approach into a cell laden biomaterial-based therapy has remained largely unexplored...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27802342/propensity-scoring-after-multiple-imputation-in-a-retrospective-study-on-adjuvant-radiation-therapy-in-lymph-node-positive-vulvar-cancer
#11
Christine Eulenburg, Anna Suling, Petra Neuser, Alexander Reuss, Ulrich Canzler, Tanja Fehm, Alexander Luyten, Martin Hellriegel, Linn Woelber, Sven Mahner
Propensity scoring (PS) is an established tool to account for measured confounding in non-randomized studies. These methods are sensitive to missing values, which are a common problem in observational data. The combination of multiple imputation of missing values and different propensity scoring techniques is addressed in this work. For a sample of lymph node-positive vulvar cancer patients, we re-analyze associations between the application of radiotherapy and disease-related and non-related survival. Inverse-probability-of-treatment-weighting (IPTW) and PS stratification are applied after multiple imputation by chained equation (MICE)...
2016: PloS One
https://www.readbyqxmd.com/read/27768171/association-of-axial-length-with-risk-of-uncorrectable-visual-impairment-for-europeans-with-myopia
#12
J Willem L Tideman, Margaretha C C Snabel, Milly S Tedja, Gwyneth A van Rijn, King T Wong, Robert W A M Kuijpers, Johannes R Vingerling, Albert Hofman, Gabriëlle H S Buitendijk, Jan E E Keunen, Camiel J F Boon, Annette J M Geerards, Gregorius P M Luyten, Virginie J M Verhoeven, Caroline C W Klaver
Importance: Myopia (ie, nearsightedness) is becoming the most common eye disorder to cause blindness in younger persons in many parts of the world. Visual impairment due to myopia is associated with structural changes of the retina and the globe because of elongation of the eye axis. How axial length-a sum of the anterior chamber depth, lens thickness, and vitreous chamber depth-and myopia relate to the development of visual impairment over time is unknown. Objectives: To evaluate the association between axial length, spherical equivalent, and the risk of visual impairment and to make projections of visual impairment for regions with high prevalence rates...
December 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27764126/upregulation-of-hla-expression-in-primary-uveal-melanoma-by-infiltrating-leukocytes
#13
T Huibertus van Essen, Sake I van Pelt, Inge H G Bronkhorst, Mieke Versluis, Fariba Némati, Cécile Laurent, Gregorius P M Luyten, Thorbald van Hall, Peter J van den Elsen, Pieter A van der Velden, Didier Decaudin, Martine J Jager
INTRODUCTION: Uveal melanoma (UM) with an inflammatory phenotype, characterized by infiltrating leukocytes and increased human leukocyte antigen (HLA) expression, carry an increased risk of death due to metastases. These tumors should be ideal for T-cell based therapies, yet it is not clear why prognostically-infaust tumors have a high HLA expression. We set out to determine whether the level of HLA molecules in UM is associated with other genetic factors, HLA transcriptional regulators, or microenvironmental factors...
2016: PloS One
https://www.readbyqxmd.com/read/27759061/changes-in-bone-macro-and-microstructure-in-diabetic-obese-mice-revealed-by-high-resolution-microfocus-x-ray-computed-tomography
#14
G Kerckhofs, M Durand, R Vangoitsenhoven, C Marin, B Van der Schueren, G Carmeliet, F P Luyten, L Geris, K Vandamme
High resolution microfocus X-ray computed tomography (HR-microCT) was employed to characterize the structural alterations of the cortical and trabecular bone in a mouse model of obesity-driven type 2 diabetes (T2DM). C57Bl/6J mice were randomly assigned for 14 weeks to either a control diet-fed (CTRL) or a high fat diet (HFD)-fed group developing obesity, hyperglycaemia and insulin resistance. The HFD group showed an increased trabecular thickness and a decreased trabecular number compared to CTRL animals. Midshaft tibia intracortical porosity was assessed at two spatial image resolutions...
October 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27744006/varus-thrust-in-women-with-early-medial-knee-osteoarthritis-and-its-relation-with-the-external-knee-adduction-moment
#15
Armaghan Mahmoudian, Jaap H van Dieen, Sjoerd M Bruijn, Isabel Ac Baert, Gert S Faber, Frank P Luyten, Sabine Mp Verschueren
BACKGROUND: Varus thrust, defined as an abrupt increase of the knee varus angle during weight-bearing in gait, has been shown to be present in patients with moderate to severe knee osteoarthritis and is considered to be one of the risk factors for progression of symptomatic medial knee osteoarthritis. We evaluated the presence and magnitude of varus thrust and its relation with the Knee Adduction Moment in women with early medial knee osteoarthritis, and compared it to that in a group of controls and in a group of subjects with established medial knee osteoarthritis...
November 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27741435/ruthenium-106-brachytherapy-for-choroidal-melanoma-without-transpupillary-thermotherapy-similar-efficacy-with-improved-visual-outcome
#16
Marina Marinkovic, Nanda Horeweg, Marta Fiocco, Femke P Peters, Linda W Sommers, Mirjam S Laman, Jaco C Bleeker, Martijn Ketelaars, Gre P M Luyten, Carien L Creutzberg
PURPOSE: To evaluate efficacy and toxicity of two different protocols for eye-conserving treatment of patients with small to intermediate-sized choroidal melanomas; the current ruthenium-106 (Ru106) brachytherapy protocol and the preceding protocol of Ru106-brachytherapy with transpupillary thermotherapy (Ru106/TTT). METHODS AND MATERIALS: Long-term outcomes of 449 consecutive patients, of whom 196 (43.6%) treated using Ru106/TTT and 253 (56.3%) treated using Ru106, were compared in terms of local control, survival, eye preservation and visual outcome...
October 11, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27721016/the-botrydial-biosynthetic-gene-cluster-of-botrytis-cinerea-displays-a-bipartite-genomic-structure-and-is-positively-regulated-by-the-putative-zn-ii-2cys6-transcription-factor-bcbot6
#17
Antoine Porquier, Guillaume Morgant, Javier Moraga, Bérengère Dalmais, Isabelle Luyten, Adeline Simon, Jean-Marc Pradier, Joëlle Amselem, Isidro González Collado, Muriel Viaud
Botrydial (BOT) is a non-host specific phytotoxin produced by the polyphagous phytopathogenic fungus Botrytis cinerea. The genomic region of the BOT biosynthetic gene cluster was investigated and revealed two additional genes named Bcbot6 and Bcbot7. Analysis revealed that the G+C/A+T-equilibrated regions that contain the Bcbot genes alternate with A+T-rich regions made of relics of transposable elements that have undergone repeat-induced point mutations (RIP). Furthermore, BcBot6, a Zn(II)2Cys6 putative transcription factor was identified as a nuclear protein and the major positive regulator of BOT biosynthesis...
November 2016: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/27687932/bioluminescent-avian-pathogenic-escherichia-coli-for-monitoring-colibacillosis-in-experimentally-infected-chickens
#18
Leon H Oosterik, Huruma N Tuntufye, Jessica Tsonos, Tom Luyten, Sam Noppen, Sandra Liekens, Rob Lavigne, Patrick Butaye, Bruno M Goddeeris
Avian pathogenic Escherichia coli (APEC) are responsible for significant economic losses in the poultry industry. In this study, a model for investigating the pathogenesis of APEC infections was established. APEC strain CH2 (O78) was marked with the luciferase operon (luxCDABE) using a Tn7 transposon and tissues of experimentally infected chickens were analysed for a correlation between the bioluminescent signal and the number of bacteria. Transposition of the lux operon into the chromosome of the APEC isolate did not affect sensitivity to lytic bacteriophages and there was no effect on virulence in an intratracheal infection model in 1-day-old chicks, although results with a subcutaneous infection model were inconclusive...
October 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27677879/preoperative-planning-with-three-dimensional-reconstruction-of-patient-s-anatomy-rapid-prototyping-and-simulation-for-endoscopic-mitral-valve-repair
#19
Peyman Sardari Nia, Samuel Heuts, Jean Daemen, Peter Luyten, Jindrich Vainer, Jan Hoorntje, Emile Cheriex, Jos Maessen
OBJECTIVES: Mitral valve repair performed by an experienced surgeon is superior to mitral valve replacement for degenerative mitral valve disease; however, many surgeons are still deterred from adapting this procedure because of a steep learning curve. Simulation-based training and planning could improve the surgical performance and reduce the learning curve. The aim of this study was to develop a patient-specific simulation for mitral valve repair and provide a proof of concept of personalized medicine in a patient prospectively planned for mitral valve surgery...
September 27, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27676444/no-effect-of-glucose-administration-in-a-novel-contextual-fear-generalization-protocol-in-rats
#20
L Luyten, N Schroyens, K Luyck, M S Fanselow, T Beckers
The excessive transfer of fear acquired for one particular context to similar situations has been implicated in the development and maintenance of anxiety disorders, such as post-traumatic stress disorder. Recent evidence suggests that glucose ingestion improves the retention of context conditioning. It has been speculated that glucose might exert that effect by ameliorating hippocampal functioning, and may hold promise as a therapeutic add-on in traumatized patients because improved retention of contextual fear could help to restrict its generalization...
2016: Translational Psychiatry
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