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https://www.readbyqxmd.com/read/29440666/folic-acid-exposure-rescues-spina-bifida-aperta-phenotypes-in-human-induced-pluripotent-stem-cell-model
#1
Vardine Sahakyan, Robin Duelen, Wai Long Tam, Scott J Roberts, Hanne Grosemans, Pieter Berckmans, Gabriele Ceccarelli, Gloria Pelizzo, Vania Broccoli, Jan Deprest, Frank P Luyten, Catherine M Verfaillie, Maurilio Sampaolesi
Neural tube defects (NTDs) are severe congenital abnormalities, caused by failed closure of neural tube during early embryonic development. Periconceptional folic acid (FA) supplementation greatly reduces the risk of NTDs. However, the molecular mechanisms behind NTDs and the preventive role of FA remain unclear. Here, we use human induced pluripotent stem cells (iPSCs) derived from fetuses with spina bifida aperta (SBA) to study the pathophysiology of NTDs and explore the effects of FA exposure. We report that FA exposure in SBA model is necessary for the proper formation and maturation of neural tube structures and robust differentiation of mesodermal derivatives...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29416527/the-impact-of-type-2-diabetes-on-bone-fracture-healing
#2
REVIEW
Carlos Marin, Frank P Luyten, Bart Van der Schueren, Greet Kerckhofs, Katleen Vandamme
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease known by the presence of elevated blood glucose levels. Nowadays, it is perceived as a worldwide epidemic, with a very high socioeconomic impact on public health. Many are the complications caused by this chronic disorder, including a negative impact on the cardiovascular system, kidneys, eyes, muscle, blood vessels, and nervous system. Recently, there has been increasing evidence suggesting that T2DM also adversely affects the skeletal system, causing detrimental bone effects such as bone quality deterioration, loss of bone strength, increased fracture risk, and impaired bone healing...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29405241/productivity-estimation-in-economic-evaluations-of-occupational-health-and-safety-interventions-a-systematic-review
#3
Jonas Steel, Lode Godderis, Jeroen Luyten
Objectives Occupational health and safety (OHS) interventions` effect on worker productivity is an essential, but complex element of the value of these programs. The trustworthiness of economic evaluation studies, aiming to provide guidance to decision-makers in the field of OHS, depends at least partly on how accurately productivity changes are measured. We aim to review the methods used to estimate productivity changes in recently published economic evaluations of OHS interventions. Methods We performed systematic searches of economic evaluations of OHS programs published between 2007 and 2017 and reviewed these studies` methods to quantify the programs` impact on worker productivity Results Of the 90 identified studies, 44 used a human capital approach, 17 a friction cost approach, 13 stated productivity in natural units (eg, a cost-per-absence-day-avoided), 7 made use of compensation expenses, 4 used output-based methods, 4 an "ad hoc" approach, and 1 study did not state its method...
February 6, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29395750/cost-effectiveness-of-ovarian-stimulation-with-gonadotrophin-and-clomiphene-citrate-in-an-intrauterine-insemination-programme-for-subfertile-couples
#4
Karen Peeraer, Jeroen Luyten, Carla Tomassetti, Sarah Verschueren, Carl Spiessens, Ann Tanghe, Christel Meuleman, Sophie Debrock, Eline Dancet, Thomas D'Hooghe
Ovarian stimulation with low-dose human menopausal gonadotrophin (HMG) is superior to clomiphene citrate in intrauterine insemination (IUI) cycles with respect to clinical pregnancy rate, but it is unclear whether HMG is also the more cost-effective option. The aim of this study was to compare the cost-effectiveness of ovarian stimulation with low-dose subcutaneously administred HMG (37.5-75 IU per day) to orally administred clomiphene citrate (50 mg/day from day 3-7) in an IUI programme for subfertile couples...
December 27, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29380706/anticancer-activity-study-of-chromone-and-coumarin-hybrids-using-electrical-impedance-spectroscopy
#5
Mustapha M Bouhenna, Monica Vara Perez, Oualid Talhi, Khaldoun Bachari, Artur M S Silva, Walter Luyten, Nabil Mameri
Oncology treatments aim at selective toxicity for tumor (compared to normal) cells, and chromone-coumarin hybrids have shown such activity. In this study, we test a novel series of synthetic chromone and coumarin derivatives (1-9) for cytotoxic activity against a panel of tumor cell lines (MCF-7, A549, HepG2, HTC-116, B16) opposed to non-tumor cells (Caco-2 and HEK-293t). Electrical impedance spectroscopy was used to monitor cell viability in real time. Compound 8 showed the most potent activity, and it significantly diminished cancer cell proliferation and viability in different cell lines...
January 29, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29366765/active-principles-of-tetradenia-riparia-iv-anthelmintic-activity-of-8-14-15-sandaracopimaradiene-7%C3%AE-18-diol
#6
Luc Van Puyvelde, Maoxuan Liu, Cedrick Veryser, Wim M De Borggraeve, Joseph Mungarulire, Marie Jeanne Mukazayire, Walter Luyten
ETHNOPHARMACOLOGICAL RELEVANCE: Tetradenia (T.) riparia (Hochst.) Codd (Lamiaceae), formerly known as Iboza riparia (Hochst.) N.E.Br., is one of the most frequently used medicinal plants in traditional Rwandese medicine. It was used as a remedy against a wide range of diseases including malaria, angina, yaws, dental abscesses, headache, worm infections and several kinds of fevers and aches. AIM OF THE STUDY: This study aims to identify the compounds active against helminths from Tetradenia riparia...
January 20, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29338133/pimasertib-associated-ophthalmological-adverse-events
#7
Elon H C van Dijk, Wim H J Kruit, Martine J Jager, Gregorius P M Luyten, Johannes R Vingerling, Camiel J F Boon
PURPOSE: To analyse ophthalmological adverse events associated with mitogen-activated protein kinase kinase (MEK) inhibition with pimasertib treatment for metastatic cutaneous melanoma (CM). METHODS: In this prospective observational, cohort-based, cross-sectional study, eight patients treated with the MEK inhibitor pimasertib received a complete ophthalmic examination. This included Early Treatment of Diabetic Retinopathy Study best-corrected visual acuity, visual field testing, colour vision testing, slit-lamp examination, applanation tonometry, indirect ophthalmoscopy, digital colour fundus photography and optical coherence tomography (OCT)...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29335516/an-evaluation-of-the-effect-of-pulse-shape-on-grey-and-white-matter-stimulation-in-the-rat-brain
#8
Marjolijn Deprez, Kelly Luyck, Laura Luyten, Tim Tambuyzer, Bart Nuttin, Myles Mc Laughlin
Despite the current success of neuromodulation, standard biphasic, rectangular pulse shapes may not be optimal to achieve symptom alleviation. Here, we compared stimulation efficiency (in terms of charge) between complex and standard pulses in two areas of the rat brain. In motor cortex, Gaussian and interphase gap stimulation (IPG) increased stimulation efficiency in terms of charge per phase compared with a standard pulse. Moreover, IPG stimulation of the deep mesencephalic reticular formation in freely moving rats was more efficient compared to a standard pulse...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29313045/thermal-stability-of-trihexyl-tetradecyl-phosphonium-chloride
#9
Clio Deferm, Arne Van den Bossche, Jan Luyten, Harald Oosterhof, Jan Fransaer, Koen Binnemans
Dynamic TGA studies of phosphonium ionic liquids have reported thermal stabilities of 300 °C or higher for these compounds. This is often an overestimation of the real thermal stability. The chosen technique as well as the experimental parameters can influence the thermal stability. In this paper, the thermal stability of commercially available Cyphos IL 101 is studied. The effect of the nature of the atmosphere (air or inert gas), the purity of the sample, the heating rate and presence of a metal on the short-term and long-term stability of commercial Cyphos IL 101 is investigated...
January 9, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29306094/simultaneous-three-dimensional-visualization-of-mineralized-and-soft-skeletal-tissues-by-a-novel-microct-contrast-agent-with-polyoxometalate-structure
#10
Greet Kerckhofs, Steve Stegen, Nick van Gastel, Annelies Sap, Guillaume Falgayrac, Guillaume Penel, Marjorie Durand, Frank P Luyten, Liesbet Geris, Katleen Vandamme, Tatjana Parac-Vogt, Geert Carmeliet
Biological tissues have a complex and heterogeneous 3D structure, which is only partially revealed by standard histomorphometry in 2D. We here present a novel chemical compound for contrast-enhanced microfocus computed tomography (CE-CT), a Hafnium-based Wells-Dawson polyoxometalate (Hf-POM), which allows simultaneous 3D visualization of mineralized and non-mineralized skeletal tissues, such as mineralized bone and bone marrow vasculature and adipocytes. We validated the novel contrast agent, which has a neutral pH in solution, by detailed comparison with (immuno)histology on murine long bones as blueprint, and showed that Hf-POM-based CE-CT can be used for virtual 3D histology...
December 22, 2017: Biomaterials
https://www.readbyqxmd.com/read/29294916/prevalence-of-exposure-to-complex-trauma-and-community-violence-and-their-associations-with-internalizing-and-externalizing-symptoms
#11
Karen Yearwood, Nicole Vliegen, Cecilia Chau, Jozef Corveleyn, Patrick Luyten
Studies about trauma often tend to focus on abuse and neglect. However important, these studies may neglect the importance of the broader community context that is often associated with trauma, and complex trauma (CT) in particular. This study aimed to investigate the effects of CT (defined in terms of experiencing abuse and/or neglect occurring in the context of relationships with caregivers), and of broader environmental adversity (i.e., exposure to community violence), in a sample of adolescents ( N = 218) from a severely disadvantaged district of Lima, Peru...
September 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29275786/glucocorticoid-receptor-dna-methylation-and-childhood-trauma-in-chronic-fatigue-syndrome-patients
#12
Elise Beau Vangeel, Stefan Kempke, Jelena Bakusic, Lode Godderis, Patrick Luyten, Leen Van Heddegem, Veerle Compernolle, Philippe Persoons, Diether Lambrechts, Benedetta Izzi, Kathleen Freson, Stephan Claes
OBJECTIVE: Although the precise mechanisms are not yet understood, previous studies have suggested that chronic fatigue syndrome (CFS) is associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation and trauma in early childhood. Consistent with findings suggesting that early life stress-induced DNA methylation changes may underlie dysregulation of the HPA axis, we previously found evidence for the involvement of glucocorticoid receptor (GR) gene (NR3C1) methylation in whole blood of CFS patients...
January 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29249047/electrolytic-post-training-lesions-of-the-bed-nucleus-of-the-stria-terminalis-block-startle-potentiation-in-a-cued-fear-conditioning-procedure
#13
Kelly Luyck, Bart Nuttin, Laura Luyten
Existing neuroanatomical models argue that the bed nucleus of the stria terminalis (BST) principally mediates sustained, long-lasting fear or anxiety responses, but not shorter, phasic fear responses, although recent studies paint a more complex picture. In the current study, we evaluated the effect of post-training electrolytic BST lesions in a cued fear conditioning protocol with relatively short (10 s) tones. We hypothesized that the BST would not play a crucial role in the expression of fear upon re-exposure to the conditioned tones...
December 16, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29232329/cortisol-and-subjective-stress-responses-to-acute-psychosocial-stress-in-fibromyalgia-patients-and-control-participants
#14
Eline Coppens, Stefan Kempke, Peter Van Wambeke, Stephan Claes, Bart Morlion, Patrick Luyten, Lukas Van Oudenhove
OBJECTIVE: Hypothalamic-pituitary-adrenal (HPA) axis dysfunction may play a role in fibromyalgia (FM) pathogenesis, but remains understudied in this disorder. Furthermore, early childhood adversities (ECA) are common in FM, but whether they moderate stress reactivity is unknown. Hence, we investigated cortisol and subjective responses to acute psychosocial stress in FM and controls, while adjusting for ECA. METHODS: Twenty-seven female FM patients and 24 age-matched female controls were recruited in a tertiary care center and through advertisements, respectively...
December 11, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29228259/the-non-specific-adenine-dna-methyltransferase-m-ecogii
#15
Iain A Murray, Richard D Morgan, Yvette Luyten, Alexey Fomenkov, Ivan R Corrêa, Nan Dai, Mohammed B Allaw, Xing Zhang, Xiaodong Cheng, Richard J Roberts
We describe the cloning, expression and characterization of the first truly non-specific adenine DNA methyltransferase, M.EcoGII. It is encoded in the genome of the pathogenic strain Escherichia coli O104:H4 C227-11, where it appears to reside on a cryptic prophage, but is not expressed. However, when the gene encoding M.EcoGII is expressed in vivo - using a high copy pRRS plasmid vector and a methylation-deficient E. coli host-extensive in vivo adenine methylation activity is revealed. M.EcoGII methylates adenine residues in any DNA sequence context and this activity extends to dA and rA bases in either strand of a DNA:RNA-hybrid oligonucleotide duplex and to rA bases in RNAs prepared by in vitro transcription...
December 8, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29179875/surgical-staging-identified-false-hpv-negative-cases-in-a-large-series-of-invasive-cervical-cancers
#16
Karl Ulrich Petry, Clemens Liebrich, Alexander Luyten, Martina Zander, Thomas Iftner
OBJECTIVE: We examined a large series of biopsy-proven invasive cervical cancers with surgical staging and HPV re-testing to estimate the relevance of HPV-negative cervical cancers in a Caucasian population. METHODS: We prospectively collected smears from 371 patients with a biopsy-proven diagnosis of cervical cancer for HC2 testing of high-risk HPV (HR-HPV). In HC2-negative cases, smears and paraffin embedded tissue blocks underwent additional HPV genotyping. RESULTS: HC2 tests showed 31/371 cases (8...
December 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/29122824/ruthenium-106-brachytherapy-for-iris-and-iridociliary-melanomas
#17
Marina Marinkovic, Nanda Horeweg, Mirjam S Laman, Jaco C Bleeker, Martijn Ketelaars, Femke P Peters, Gre P M Luyten, Carien L Creutzberg
BACKGROUND AND PURPOSE: To evaluate ruthenium-106 (Ru106) brachytherapy as eye-conserving treatment of iris melanomas (IMs) and iridociliary melanomas (ICMs). MATERIALS AND METHODS: Eighty-eight patients received Ru106 brachytherapy between 2006 and 2016. Primary outcome was local control, and secondary outcomes were metastasis, survival, eye preservation, complications and visual acuity (VA). RESULTS: Overall median follow-up was 36 months...
November 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29122819/treatment-of-conjunctival-melanoma-in-a-dutch-referral-centre
#18
Niels J Brouwer, Marina Marinkovic, Sjoerd G van Duinen, Jaco C Bleeker, Martine J Jager, Gregorius P M Luyten
AIMS: To evaluate the treatment of conjunctival melanoma at a large Dutch referral centre and to make recommendations for clinical management. METHODS: A retrospective review was performed of clinical and histological data of 70 patients treated for a primary conjunctival melanoma between 2001 and 2014 at the Leiden University Medical Center, Leiden, the Netherlands. Detailed follow-up data were available for all patients. RESULTS: The mean follow-up time was 70...
November 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29109684/antimicrobial-anthelmintic-and-antiviral-activity-of-plants-traditionally-used-for-treating-infectious-disease-in-the-similipal-biosphere-reserve-odisha-india
#19
Sujogya K Panda, Laxmipriya Padhi, Pieter Leyssen, Maoxuan Liu, Johan Neyts, Walter Luyten
In the present study, we tested in vitro different parts of 35 plants used by tribals of the Similipal Biosphere Reserve (SBR, Mayurbhanj district, India) for the management of infections. From each plant, three extracts were prepared with different solvents (water, ethanol, and acetone) and tested for antimicrobial (E. coli, S. aureus, C. albicans); anthelmintic (C. elegans); and antiviral (enterovirus 71) bioactivity. In total, 35 plant species belonging to 21 families were recorded from tribes of the SBR and periphery...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29107398/the-stress-reward-mentalizing-model-of-depression-an-integrative-developmental-cascade-approach-to-child-and-adolescent-depressive-disorder-based-on-the-research-domain-criteria-rdoc-approach
#20
REVIEW
Patrick Luyten, Peter Fonagy
The Research Domain Criteria (RDoC) propose a much-needed change in approach to the study of vulnerability factors implicated in mental disorders, shifting away from a categorical, disease-oriented model to a dimensional approach that focuses on underlying systems implicated in psychopathology. In this paper we illustrate this approach with a focus on the emergence of depression in childhood and adolescence. Based on evolutionary biological and developmental psychopathology considerations, we present an integrative developmental cascade model of depression that essentially suggests that depression emerges out of a three-pronged series of interacting impairments in the domains of stress regulation, reward, and mentalizing...
October 9, 2017: Clinical Psychology Review
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