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https://www.readbyqxmd.com/read/29031184/gene-environment-interactions-between-stress-and-5-httlpr-in-depression-a-meta-analytic-update
#1
REVIEW
Dries Bleys, Patrick Luyten, Bart Soenens, Stephan Claes
BACKGROUND: Meta-analyses have yielded contradictory findings concerning the role of 5-HTTLPR in interaction with stress (GxE) in depression. The current meta-analysis investigates if these contradictory findings are a result of differences between studies in methodological approaches towards the assessment of stress and depression. METHODS: After performing a systematic database search (February to December 2016), first, a meta-analysis was used to investigate the total effect size and publication bias...
October 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29024891/mentalizing-and-interpersonal-problems-in-borderline-personality-disorder-the-mediating-role-of-identity-diffusion
#2
Celine De Meulemeester, Benedicte Lowyck, Rudi Vermote, Yannic Verhaest, Patrick Luyten
Individuals with borderline personality disorder (BPD) are characterized by problems in interpersonal functioning and their long-term social integration often remains problematic. Extant theories have linked identity diffusion to many of the interpersonal problems characteristic of BPD patients. Recent theoretical accounts have suggested that identity diffusion results from problems with mentalizing or reflective functioning, that is, the capacity to understand oneself and others in terms of intentional mental states...
September 28, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28993161/new-class-of-early-stage-enterovirus-inhibitors-with-a-novel-mechanism-of-action
#3
Yipeng Ma, Rana Abdelnabi, Leen Delang, Mathy Froeyen, Walter Luyten, Johan Neyts, Carmen Mirabelli
4-dimethylamino benzoic acid (compound 12, synonym: 4EDMAB) was identified as an in vitro inhibitor of Coxsackie virus B3 (CVB3) replication in CPE-based assays (EC50 of 9.1 ± 1.5 μM). Next, the activity of twenty-three analogues was assessed, their structure-activity relationship was deduced and a more potent analogue was identified (EC50 of 2.6 ± 0.5 μM). The antiviral activity of 4EDMAB was further confirmed by quantifying viral RNA yield. Time-of-drug-addition assay revealed that 4EDMAB exerts its antiviral activity at the early stages of virus replication...
October 6, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28987025/an-integrated-bioprocess-for-the-expansion-and-chondrogenic-priming-of-human-periosteum-derived-progenitor-cells-in-suspension-bioreactors
#4
Priyanka Gupta, Liesbet Geris, Frank P Luyten, Ioannis Papantoniou
The increasing use of microcarrier based suspension bioreactors for scalable expansion of adult progenitor cells in recent years reveals the necessity of such approaches to address bio manufacturing challenges of advanced therapeutic medicinal products. However, the differentiation of progenitor cells within suspension bioreactors for the production of tissue modules is of equal importance but not well investigated. This study reports on the development of a bioreactor based integrated process for expansion and chondrogenic priming of human periosteum derived stem cells (hPDCs) using Cultispher S microcarriers...
October 7, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28985628/a-mentalization-based-approach-to-common-factors-in-the-treatment-of-borderline-personality-disorder
#5
REVIEW
Anthony Bateman, Chloe Campbell, Patrick Luyten, Peter Fonagy
In this paper we conceptualize borderline personality disorder as a disorder of mentalizing, social cognition, and loss of resilience. Several treatment approaches are effective, and meta-analyses suggest that there are few substantive differences in effectiveness between them and between specialized and non-specialized approaches. We propose that these findings arise because of shared mechanisms of change, congruent with current thinking both about the existence of a general 'p' factor of psychopathology and a reconceptualization of personality disorders as involving a lack of resilience resulting from problems with epistemic trust and salutogenesis, the capacity to derive benefit from the social environment...
September 14, 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28985489/changes-in-gait-characteristics-of-women-with-early-and-established-medial-knee-osteoarthritis-results-from-a-2-years-longitudinal-study
#6
Armaghan Mahmoudian, Jaap H van Dieёn, Isabel A C Baert, Sjoerd M Bruijn, Gert S Faber, Frank P Luyten, Sabine M P Verschueren
BACKGROUND: Despite the large number of cross-sectional studies on gait in subjects with knee osteoarthritis, there are scarcely any longitudinal studies on gait changes in knee osteoarthritis. METHODS: Gait analysis was performed on 25 women with early and 18 with established medial knee osteoarthritis, as well as a group of 23 healthy controls. Subjects were asked to walk at their comfortable speed. Kinematic and kinetic data were measured at baseline and after 2years follow-up...
October 2, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28968563/changes-in-interpersonal-problems-in-the-psychotherapeutic-treatment-of-depression-as-measured-by-the-inventory-of-interpersonal-problems-a-systematic-review-and-meta-analysis
#7
REVIEW
Tara McFarquhar, Patrick Luyten, Peter Fonagy
BACKGROUND: Interpersonal problems are commonly reported by depressed patients, but the effect of psychotherapeutic treatment on them remains unclear. This paper reviews the effectiveness of psychotherapeutic interventions for depression on interpersonal problems as measured by the Inventory of Interpersonal Problems (IIP). METHODS: An electronic database search identified articles reporting IIP outcome scores for individual adult psychotherapy for depression. A systematic review and, where possible, meta-analysis was conducted...
September 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28961665/bias-toward-psychodynamic-therapy-framing-the-problem-and-working-toward-a-solution
#8
Allan Abbass, Patrick Luyten, Christiane Steinert, Falk Leichsenring
Although psychodynamic therapy (PDT) is an evidence-based intervention for a broad spectrum of psychiatric conditions, there is often notable bias in the way PDT is depicted both in the popular media and in the scientific literature. This has contributed to a negative view of PDT, which hampers both patient access to this treatment and researcher access to funding for further research on PDT. The adverse effects of these distortions and biases are detrimental not only to PDT but also to the overall field of psychotherapy, raising questions about its credibility...
September 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28947760/two-genomes-of-highly-polyphagous-lepidopteran-pests-spodoptera-frugiperda-noctuidae-with-different-host-plant-ranges
#9
Anaïs Gouin, Anthony Bretaudeau, Kiwoong Nam, Sylvie Gimenez, Jean-Marc Aury, Bernard Duvic, Frédérique Hilliou, Nicolas Durand, Nicolas Montagné, Isabelle Darboux, Suyog Kuwar, Thomas Chertemps, David Siaussat, Anne Bretschneider, Yves Moné, Seung-Joon Ahn, Sabine Hänniger, Anne-Sophie Gosselin Grenet, David Neunemann, Florian Maumus, Isabelle Luyten, Karine Labadie, Wei Xu, Fotini Koutroumpa, Jean-Michel Escoubas, Angel Llopis, Martine Maïbèche-Coisne, Fanny Salasc, Archana Tomar, Alisha R Anderson, Sher Afzal Khan, Pascaline Dumas, Marion Orsucci, Julie Guy, Caroline Belser, Adriana Alberti, Benjamin Noel, Arnaud Couloux, Jonathan Mercier, Sabine Nidelet, Emeric Dubois, Nai-Yong Liu, Isabelle Boulogne, Olivier Mirabeau, Gaelle Le Goff, Karl Gordon, John Oakeshott, Fernando L Consoli, Anne-Nathalie Volkoff, Howard W Fescemyer, James H Marden, Dawn S Luthe, Salvador Herrero, David G Heckel, Patrick Wincker, Gael J Kergoat, Joelle Amselem, Hadi Quesneville, Astrid T Groot, Emmanuelle Jacquin-Joly, Nicolas Nègre, Claire Lemaitre, Fabrice Legeai, Emmanuelle d'Alençon, Philippe Fournier
Emergence of polyphagous herbivorous insects entails significant adaptation to recognize, detoxify and digest a variety of host-plants. Despite of its biological and practical importance - since insects eat 20% of crops - no exhaustive analysis of gene repertoires required for adaptations in generalist insect herbivores has previously been performed. The noctuid moth Spodoptera frugiperda ranks as one of the world's worst agricultural pests. This insect is polyphagous while the majority of other lepidopteran herbivores are specialist...
September 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28945785/signaling-properties-of-the-human-chemokine-receptors-cxcr4-and-cxcr7-by-cellular-electric-impedance-measurements
#10
Jordi Doijen, Tom Van Loy, Wouter De Haes, Bart Landuyt, Walter Luyten, Liliane Schoofs, Dominique Schols
The chemokine receptor 4 (CXCR4) and 7 (CXCR7) are G-protein-coupled receptors involved in various diseases including human cancer. As such, they have become important targets for therapeutic intervention. Cell-based receptor assays, able to detect agents that modulate receptor activity, are of key importance for drug discovery. We evaluated the potential of cellular electric impedance for this purpose. Dose-dependent and specific stimulation of CXCR4 was detected upon addition of its unique chemokine ligand CXCL12...
2017: PloS One
https://www.readbyqxmd.com/read/28939390/exploring-parental-mentalization-in-postnatal-phase-with-a-self-report-questionnaire-prfq-factor-structure-gender-differences-and-association-with-sociodemographic-factors-the-finn-brain-birth-cohort-study
#11
Marjukka Pajulo, Mimmi Tolvanen, Nina Pyykkönen, Linnea Karlsson, Linda Mayes, Hasse Karlsson
The objective was to explore the preliminary functioning of a self-report questionnaire designed to assess parental reflective functioning (PRFQ, Luyten et al., 2009, unpublished manual) during early postnatal phase and with a large population-based sample. Parental reflective functioning (PRF) refers to parental capacity to focus on experience and feelings, within self, in the child and underlying observed reactions. Individual differences in PRF reportedly affect child attachment and socio-emotional development...
September 11, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28935341/conduct-problems-in-youth-and-the-rdoc-approach-a-developmental-evolutionary-based-view
#12
REVIEW
Peter Fonagy, Patrick Luyten
Problems related to aggression in young people are traditionally subsumed under the header of conduct problems, which include conduct disorder and oppositional defiant disorder. Such problems in children and adolescents are an important societal and mental health problem. In this paper we present an evolutionarily informed developmental psychopathology view of conduct problems inspired by the NIMH Research Domain Criteria (RDoC) initiative. We assume that while there are many pathways to conduct problems, chronic or temporary impairments in the domain of social cognition or mentalizing are a common denominator...
September 8, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28919106/selecting-relevant-features-from-the-electronic-health-record-for-clinical-code-prediction
#13
Elyne Scheurwegs, Boris Cule, Kim Luyckx, Léon Luyten, Walter Daelemans
A multitude of information sources is present in the electronic health record (EHR), each of which can contain clues to automatically assign diagnosis and procedure codes. These sources however show information overlap and quality differences, which complicates the retrieval of these clues. Through feature selection, a denser representation with a consistent quality and less information overlap can be obtained. We introduce and compare coverage-based feature selection methods, based on confidence and information gain...
October 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28917712/toward-classification-criteria-for-early-osteoarthritis-of-the-knee
#14
F P Luyten, S Bierma-Zeinstra, F Dell'Accio, V B Kraus, K Nakata, I Sekiya, N K Arden, L S Lohmander
OBJECTIVE: To propose draft classification criteria for early stage osteoarthritis (OA) of the knee for use in a primary care setting. METHODS: A group of basic scientists, physician-scientists, rheumatologists, orthopedic surgeons, and physiotherapists in a workshop setting discussed potential classification criteria for early osteoarthritis of the knee. The workshop was divided into sessions around relevant topics with short state of the art presentations followed by breakout sessions, consensus discussions, and consolidation into a consensus document...
August 9, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28900037/znf143-is-an-important-regulator-of-the-myeloid-transcription-factor-c-ebp%C3%AE
#15
David Gonzalez, Annouck Luyten, Boris Bartholdy, Qiling Zhou, Miroslava Kardosova, Alex Ebralidze, Kenneth D Swanson, Hanna Radomska, Pu Zhang, Susumu S Kobayashi, Robert S Welner, Elena Levantini, Ulrich Steidl, Gilbert Chong, Samuel Collombet, Min Hee Choi, Alan D Friedman, Linda M Scott, Meritxell Alberich-Jorda, Daniel G Tenen
The transcription factor (TF) C/EBPα is essential for myeloid differentiation and is frequently dysregulated in acute myeloid leukemia (AML). While studied extensively, the precise regulation of its gene by upstream factors has remained largely elusive. Here, we investigated its transcriptional activation during myeloid differentiation. We identified an evolutionarily conserved octameric sequence, CCCAGCAG, approximately 100 bases upstream of the CEBPA transcription start site (TSS), and demonstrated through mutational analysis that this sequence is crucial for C/EBPα expression...
September 12, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28899197/personality-psychopathology-and-health-through-the-lens-of-interpersonal-relatedness-and-self-definition
#16
Patrick Luyten
Sidney Blatt's seminal contributions in the domain of personality development, psychopathology, and health rank among the best researched and most empirically supported theories in psychoanalysis. Blatt is known primarily for his two-polarities model of personality development, which he viewed as evolving through a dialectical, synergistic interaction between two fundamental processes across the lifespan: the development of interpersonal relatedness on the one hand, and of self-definition on the other. In this model, psychopathology is viewed as an attempt to find a balance, however distorted, between relatedness and self-definition...
June 2017: Journal of the American Psychoanalytic Association
https://www.readbyqxmd.com/read/28875574/rgd-functionalized-polyethylene-glycol-hydrogels-support-proliferation-and-in-vitro-chondrogenesis-of-human-periosteum-derived-cells
#17
Abhijith K Kudva, Frank P Luyten, Jennifer Patterson
The combination of progenitor cells with appropriate scaffolds and in vitro culture regimes is a promising area of research in bone and cartilage tissue engineering. Mesenchymal stem cells (MSCs), when encapsulated within hydrogels composed of the necessary cues and/or preconditioned using suitable culture conditions, have been shown to differentiate into bone or cartilage. Here, we utilized human periosteum-derived cells (hPDCs), a progenitor cell population with MSC characteristics, paired with protease-degradable, functionalized polyethylene glycol (PEG) hydrogels to create tissue-engineered constructs...
September 5, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28875425/initiating-human-articular-chondrocyte-re-differentiation-in-a-3d-system-after-2d-expansion
#18
Abhijith K Kudva, Frank P Luyten, Jennifer Patterson
Cartilage damage affects a large population via acute and chronic injury and disease. Since native cartilage does not self-renew, cartilage tissue engineering has gained traction as a potential treatment. However, a limiting factor is that the primary cell type in cartilage, the articular chondrocyte, tends to de-differentiate when grown on 2D surfaces for in vitro expansion. Thus, 3D systems are being developed and used to counter this loss of chondrogenic capabilities. We hypothesize that a 3D matrix that can be remodeled may be more supportive of the chondrogenic phenotype of encapsulated articular chondrocytes than a 2D surface and may allow for the re-differentiation of chondrocytes after 2D expansion...
September 5, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28873769/reconnecting-people-with-dementia-by-using-the-interactive-instrument-crdl
#19
Lisanne Teunissen, Tom Luyten, Luc de Witte
Dementia is a progressive brain disease with a decline in functioning over time. CRDL (pronounced as Cradle) is an interactive instrument, developed to stimulate communication between users through sound and touch. It recognises the intention of the touch (tickle, holding, grabbing, fondling, kneading, and tapping) and will adjust the sound accordingly. This qualitative observational study explores whether this innovative product has the potential to be used in elderly care to create a moment of interaction between the person with dementia and someone else or multiple others...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28868281/multiple-pigmented-conjunctival-lesions-following-intravitreal-injections-in-a-patient-with-uveal-melanoma
#20
Niels J Brouwer, Gregorius P M Luyten, Sjoerd G van Duinen, Martine J Jager, Marina Marinkovic
PURPOSE: This paper reports a case of pigmented conjunctival lesions after intravitreal injections in a patient who received brachytherapy for uveal melanoma. METHODS: Clinical and histopathological examination of the pigmented conjunctival lesions was performed. RESULTS: A 57-year-old male who was treated with brachytherapy for uveal melanoma developed radiation retinopathy. Following intravitreal anti-vascular endothelial growth factor (VEGF) injections, 2 pigmented conjunctival spots appeared at the injection sites...
July 2017: Ocular Oncology and Pathology
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