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colorectal cancer AND lncRNA

Ting Ma, Rui-Ping Wang, Xi Zou
BACKGROUND: As a member of non-coding RNAs family, long non-coding RNAs' functions in cancer needs to be further investigated. It has been indicated that the functions of Hox transcript antisense intergenic RNA (lncRNA: HOTAIR) include reprogramming chromatin organization and promoting tumor metastasis such as breast and colorectal tumor. The aim of this study is to investigate the functions of Hox in gastric cancer. METHODS: In the present study, the expression level of HOTAIR was determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR), 20 gastric cancer tissues and 20 normal tissues was included...
September 30, 2016: BMC Complementary and Alternative Medicine
Mingqi Li, Cheng Yang, Xin Liu, Liang Yuan, Fubin Zhang, Muhong Wang, Dazhuang Miao, Xinyue Gu, Shixiong Jiang, Binbin Cui, Jinxue Tong, Zhiwei Yu
Ephrin Type-A Receptor 3 (EphA3) belongs to the ephrin receptor subfamily of the protein tyrosine kinase family, and plays an important role in embryogenesis and neurogenesis. This study aimed to investigate the role of EphA3 in promoting malignant transformation of colorectal epithelial cells, and explore underlying molecular mechanisms. Colorectal cancer tissue specimens from 68 patients were analyzed for EphA3 expression. EphA3 expression levels were manipulated in rat colon epithelial cell lines. We found that EphA3 expression level in tumor tissues was associated with patient age (P = 0...
October 6, 2016: Cancer Letters
(no author information available yet)
The GMR editorial staff was alerted about some manuscripts that were found to be substantially equal. The Publisher and Editor decided to retract these articles in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation, we have strong reason to believe that the peer review process was failure and, after review and contacting the authors, the editors of Genetics and Molecular Research decided to retract these articles. The authors and their institutions were advised of this serious breach of ethics...
September 30, 2016: Genetics and Molecular Research: GMR
Haiting Zhao, Renjun Peng, Qing Liu, Dingyang Liu, Peng Du, Jian Yuan, Gang Peng, Yiwei Liao
H19, one of the first found cancer-associated long non-coding RNAs (lncRNAs), is involved in the development and progression of many types of tumors. An aberrant expression of H19 was observed in hepatocellular carcinoma, cervical cancer, breast cancer, ovarian cancer, and colorectal cancer. However, the exact effects and molecular mechanisms of H19 in glioma progression are still unknown up to now. In this study, we investigated the role of H19 in human glioma cell lines and clinical tumor samples in order to determine the function of this molecule...
September 28, 2016: Archives of Biochemistry and Biophysics
Chuanxi Wang, Jinyu Yu, Yuping Han, Leping Li, Jie Li, Tao Li, Peng Qi
Colorectal cancer (CRC) is currently the most prevalent malignant cancer worldwide. However, there is a lack of efficient biomarkers for CRC screening. Accumulating evidence reveals that long non-coding RNAs (lncRNAs) detectable in serum are associated with the genesis and development of various types of cancer. Therefore, we examined the diagnostic ability of lncRNAs in blood samples from patients with CRC by evaluating the levels of 17 CRC- or gastrointestinal cancer-related lncRNAs in serum samples from 71 CRC patients and 70 healthy individuals using reverse transcription-quantitative polymerase chain reaction (RT-qPCR)...
September 23, 2016: Oncotarget
Qi Liao, Linbo Chen, Jianfa Liu, Tao Yang, Jincheng Li, Xiaohong Zhang, Jinshun Zhao
Colorectal cancer (CRC) is one of the most common and severe cancers worldwide. The occurrence of CRC is developed by accumulation of genetic and epigenetic alteration in colon cells. Work over the last decade has proposed that epigenetic changes such as DNA methylation, histone modification of protein coding genes play an important role in CRC development. However, the epigenetic pattern and features of lncRNAs in CRC were unclear. Here, we comprehensively analyze the patterns of DNA methylation, H3K4me3, H3K27me3 on both protein coding genes and lncRNAs...
September 15, 2016: Gene
Min Lu, Zhuo Liu, Bo Li, Gang Wang, Dechuan Li, Yuping Zhu
BACKGROUND: Long non-coding RNAs (lncRNAs) have been shown to have crucial regulatory roles in human cancer biology. LncRNA PANDAR is a novel identified lncRNA that was previously reported to be increased in various cancers; however, its effect in colorectal cancer (CRC) remains unknown. The aim of this study was to explore the expression and role of lncRNA PANDAR in CRC. METHODS: The expression of lncRNA PANDAR was examined in CRC samples and cell lines by qRT-PCR...
September 14, 2016: Journal of Cancer Research and Clinical Oncology
J Liu, J Wang, Y Song, Y Yang, Y Hu, P Gao, J Sun, X Chen, Y Xu, Z Wang
Long non-coding RNAs (lncRNAs) occupy the majority of the human genome. Their dysregulation is usually related with the procession of diseases, including tumors. Abnormally expressed lncRNAs have been found in colorectal cancer (CRC), but are not fully understood. In the current study, we determined the expression level of a novel lncRNA-RP1-13P20.6 in 99 pairs of CRC tissues compared to their matched normal adjacent tissues, using real time polymerase chain reaction. We further assessed the correlation between their expression levels and their clinicopathological parameters, and determined the potential of RP1-13P20...
September 6, 2016: Neoplasma
Q Li, Y Dai, F Wang, S Hou
Colorectal cancer (CRC) is a disease with high incidence, especially in developed countries. Long non-coding RNAs (lncRNAs) are new research hotspots for their vital roles in regulating gene expression. This study aims to investigate the prognostic value of lncRNAs in CRC patients. A total of 21 cancer-related lncRNAs were detected by PCR array to reveal their expression changes in CRC tissue. A 120-week-long follow-up was performed in 30 CRC patients to analyze the relationship between lncRNA levels and CRC prognosis...
September 6, 2016: Neoplasma
Rui Wang, Lutao Du, Xiaoyun Yang, Xiumei Jiang, Weili Duan, Suzhen Yan, Yujiao Xie, Yuntao Zhu, Qingliang Wang, Lili Wang, Yongmei Yang, Chuanxin Wang
BACKGROUND: Colorectal cancer (CRC) is prevalent worldwide, and improvements in timely and effective diagnosis are imperatively needed. We aimed to identify potential long noncoding RNA (lncRNA) biomarkers for CRC diagnosis along with prognosis prediction. METHODS: LncRNA expression profiles were studied by microarray in paired tumor and normal tissues from six patients with CRC. The expression levels of candidate lncRNAs were analyzed in 80 pairs of tissues and two independent cohorts of serum samples...
November 2016: Journal of Cancer Research and Clinical Oncology
Xu Han, Lingling Wang, Yu Ning, Shuang Li, Zhenjun Wang
BACKGROUND AND OBJECTIVE: Long non-coding RNAs can regulate tumorigenesis of various cancers. Dys-regulation of lncRNA-AFAP1-AS1 has not been studied in colorectal carcinoma (CRC). This study was to examine the function involvement of AFAP1-AS1 in tumor growth and metastasis of CRC. METHODS: Relative expression of AFAP1-AS1 in CRC tissues and CRC cells lines was determined using quantitative real-time PCR (qRT-PCR). Functional involvement of AFAP1-AS1 in tumor proliferation and metastasis was evaluated in AFAP1-AS1-specific siRNA-treated CRC cells and in CRC cell xenograft...
2016: Biological Research
Hong-Lei Luo, Ming-de Huang, Jia-Ni Guo, Rui-Hua Fan, Xiao-Tian Xia, Jing-Dong He, Xiao-Fei Chen
Recent findings indicate that long noncoding RNAs (lncRNAs) were dysregulated in many kinds of tumors including esophageal squamous cell carcinoma (ESCC). LncRNA AFAP1-AS1 was found to be upregulated in hepatocellular carcinoma (HCC), lung cancer, colorectal cancer, esophageal adenocarcinoma (EAC), pancreatic ductal adenocarcinoma, and nasopharyngeal carcinoma, while its clinical value and potential function in ESCC are still unknown. Expression of AFAP1-AS1 was measured in 65 ESCC tissues and corresponding noncancerous tissues by quantitative real-time polymerase chain reaction, which revealed that AFAP1-AS1 expression was markedly elevated in ESCC tissues and significantly associated with advanced TNM stage (P = 0...
August 30, 2016: Cancer Medicine
Yuan Li, Shengkai Huang, Yan Li, Weilong Zhang, Kun He, Mei Zhao, Hong Lin, Dongdong Li, Honggang Zhang, Zhaoxu Zheng, Changzhi Huang
Increasing evidence suggests that long non-coding RNAs (lncRNAs) are aberrantly expressed in colorectal cancer (CRC); however, only few CRC-related lncRNAs have been characterized. In this study, we aimed to dig out potential dysregulated lncRNAs that are highly involved in CRC development. Using a lncRNA-mining approach, we performed lncRNA expression profiling in a large CRC cohort from Gene Expression Ominus (GEO), GSE39582 test series (N = 585). We identified 31 downregulated lncRNAs and 16 upregulated lncRNAs from the GSE39582 test series patients (566 tumor patients and 19 normal controls)...
August 23, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yifan Lian, Zeling Cai, Huangbo Gong, Songling Xue, Dongdong Wu, Keming Wang
Long non-coding RNAs (lncRNAs), which represent a novel group of non-protein-coding RNAs and are commonly defined as RNA molecules larger than 200 nucleotides in length, have been shown to get involved in diverse biological processes, such as cell growth, apoptosis, migration and invasion. In addition, aberrant expression of lncRNAs has been discovered in human tumors, where they function as either oncogenes or tumor suppressor genes. Recently tumorigenic effects of one specific lncRNA, termed as 'HOXA transcript at the distal tip' (HOTTIP), on the initiation and progression of human cancer has been widely reported...
October 18, 2016: Molecular BioSystems
Xiao-Jun Yang, Chao-Qun Huang, Chun-Wei Peng, Jin-Xuan Hou, Jiu-Yang Liu
Recently, long noncoding RNAs (lncRNAs) have been emerged as crucial regulators of human diseases and prognostic markers in numerous of cancers, including colorectal carcinoma (CRC). Here, we identified an oncogenetic lncRNA HULC, which may promote colorectal tumorigenesis. HULC has been found to be up-regulated and acts as oncogene in gastric cancer and hepatocellular carcinoma, but its expression pattern, biological function and underlying mechanism in CRC is still undetermined. Here, we reported that HULC expression is also over-expressed in CRC, and its increased level is associated with poor prognosis and shorter survival...
October 30, 2016: Gene
Shifeng Chen, Hong Wu, Na Lv, Hongling Wang, Yushu Wang, Qianqing Tang, Huiyuan Shao, Chengming Sun
LncRNA colon cancer-associated transcript 2 (CCAT2) was firstly discovered and found overexpressed in colorectal cancer, and identified as is oncogenic lncRNA. However, the significance of CCAT2 in small cell lung cancer (SCLC) remains unclear. The expression of CCAT2 in SCLC tissues and cell lines was detected, and the association between CCAT2 expression and clinicopathological factors was analyzed. Cell proliferation and invasion assays were conducted by using SCLC cell lines transfected with CCAT2-siRNA or NC-siRNA...
August 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jianlu Kong, Wenjie Sun, Chen Li, Ledong Wan, Shuo Wang, Yihua Wu, Enping Xu, Honghe Zhang, Maode Lai
Long non-coding RNAs (lncRNAs) play crucial roles in many biological and pathological processes, including tumor metastasis. Here we reported a novel lncRNA, LINC01133 that was downregulated by TGF-β, which could inhibit epithelial-mesenchymal transition (EMT) and metastasis in colorectal cancer (CRC) cells. An alternative splicing factor SRSF6 was identified to directly interact with LINC01133, and SRSF6 promoted EMT and metastasis in CRC cells independent of LINC01133 And we confirmed that the EMT process was regulated by LINC01133 in CRC cells dependent on the presence of SRSF6...
October 1, 2016: Cancer Letters
Jiang Qiu, Yehui Chen, Gang Huang, Zhi Zhang, Lizhong Chen, Ning Na
AIM: Long noncoding RNAs (lncRNAs) are novel intracellular noncoding ribonucleotides regulating the genome and proteome. The lncRNA activated by transforming growth factor β (TGF-β) (lncRNA-ATB) was discovered as a prognostic factor in hepatocellular carcinoma, gastric cancer, and colorectal cancer. However, little is known about the role of lncRNA-ATB in renal transplantation. This study aimed to assess lncRNA-ATB expression in renal transplant patients with acute kidney injury and explore its role in postoperative pharmaceutical immunosuppression therapy...
July 14, 2016: Nephrology
Le-Chi Ye, Tao Chen, De-Xiang Zhu, Shi-Xu Lv, Jun-Jun Qiu, Jianmin Xu, Feng-Lai Yuan, Ye Wei
Over-expression of long non-coding RNA (lncRNA)-CLMAT3 is significantly associated with colorectal liver metastasis and is an independent predictor of poor survival for colorectal cancer patients. However, as little is known regarding the role of this gene in the proliferation of colorectal cancer in vitro, we investigated the involvement of lncRNA-CLMAT3 in colorectal cancer cell proliferation. In this study, we demonstrate that lncRNA-CLMAT3 expression was significantly increased in colorectal cancer cells compared with a normal intestinal mucous cell line and that inhibition of lncRNA-CLMAT3 suppressed colorectal cancer cell proliferation in vitro...
July 6, 2016: Oncotarget
H Song, L-M Han, Q Gao, Y Sun
OBJECTIVE: Medulloblastoma is the most common malignant brain tumor in children. Despite remarkable advances over the past decades, a novel therapeutic strategy is urgently required to increase long-term survival. This study aimed to understand the role of a long non-coding RNA (lncRNA), colorectal neoplasia differentially expressed (CRNDE), in medulloblastoma tumor growth. MATERIALS AND METHODS: The transcript level of CRNDE was initially examined in dissected clinical tissues and cultured cancerous cells...
June 2016: European Review for Medical and Pharmacological Sciences
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