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colorectal cancer AND lncRNA

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https://www.readbyqxmd.com/read/29439310/lncrna-ab073614-induces-epithelial-mesenchymal-transition-of-colorectal-cancer-cells-via-regulating-the-jak-stat3-pathway
#1
Jinfang Xue, Liya Liao, Fang Yin, Haoyu Kuang, Xiaojun Zhou, Yanan Wang
BACKGROUND: LncRNAs are involved in the metastasis and recurrence of human tumors, including colorectal cancer (CRC). We previously reported that lncRNA AB073614 promotes tumor proliferation and metastasis and predicted a poor clinical outcome of CRC patients. Herein, we investigated the underlying mechanism of lncRNA AB073614-related metastasis in CRC. MATERIAL AND METHODS: The expression of lncRNA AB073614 in CRC tissues were evaluated by quantitative real-time PCR (qRT-PCR)...
January 26, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29436686/downregulation-of-the-long-non-coding-rna-xloc_010588-inhibits-the-invasion-and-migration-of-colorectal-cancer
#2
Yue Li, Lin Zhao, Yining Zhang, Lin Guan, Huijing Zhang, Huan Zhou, Tong Gao, Peng Miao, Mingjun Sun
Long non-coding RNAs (lncRNAs) have emer-ged as major players in many biological and pathological processes; however, investigation into the function of lncRNAs in the development and progression of cancer is in its infancy. Therefore, clarification of the mechanism by which cancer‑related lncRNAs function is of critical importance in research on tumorigenesis. It has been demonstrated that the lncRNA XLOC_010588 is expressed at a low level in cervical cancer, and that this has significant impact on the proliferation of cervical cancer cells...
February 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29436635/differential-expression-profiles-of-long-noncoding-rna-and-mrna-in-colorectal-cancer-tissues-from-patients-with-lung-metastasis
#3
Ruo Shu, Yu Xu, Yan Tian, Yujian Zeng, Liang Sun, Fangyou Gong, Yi Lei, Kunhua Wang, Huayou Luo
Lungs are the most common extra‑abdominal site of metastasis of colorectal cancer (CRC), in which long noncoding RNA (lncRNA) may serve a role. In the present study, a high‑throughput microarray assay was performed to detect lncRNA expression and identify novel targets for further study of lung metastasis in CRC. In the CRC tissues from patients with lung metastasis, 7,632 lncRNA (3,574 upregulated and 4,058 downregulated) and 6,185 mRNA (3,394 upregulated and 2,791 downregulated) were detected to be differentially expressed with a fold change ≥2 and P<0...
February 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29434883/lncrna-fam83h-as1-is-associated-with-the-prognosis-of-colorectal-carcinoma-and-promotes-cell-proliferation-by-targeting-the-notch-signaling-pathway
#4
Song Lu, Wei Dong, Pei Zhao, Zhenjun Liu
The long non-coding RNA, FAM83H antisense RNA 1 (head to head) (FAM83H-AS1), has exhibited a functional role as an oncogene in a number of different types of cancer. The aim of the present study was to reveal the dysregulation of FAM83H-AS1 in colorectal carcinoma (CRC) samples and elucidate its underlying associations with the Notch signaling pathway. The expression profiles of FAM83H-AS1 and two Notch signaling-associated molecules, Notch1 and Hes family basic-helix-loop-helix transcription factor 1 (Hes1), were measured by reverse transcription-polymerase chain reaction and western blot analysis...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29427222/long-noncoding-rna-gaplinc-promotes-cells-migration-and-invasion-in-colorectal-cancer-cell-by-regulating-mir-34a-c-met-signal-pathway
#5
Yuqi Luo, Jun Ouyang, Donggen Zhou, Shizhen Zhong, Minjie Wen, Wentao Ou, Haitao Yu, Lin Jia, Yaoxin Huang
BACKGROUND: Gastric adenocarcinoma predictive long intergenic noncoding RNA (GAPLINC) has been detected in colorectal cancer (CRC) cells and reportedly performs many functions related to tumor proliferation and metastasis. Aim The present study aimed to comprehensively explore the biological functions of GAPLINC and their underlying mechanism in CRC cell. METHODS: The human cancer LncRNA PCR array was used to detect the differentially expressed long noncoding RNAs in human CRC samples...
February 9, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29410604/exosomal-lncrna-91h-is-associated-with-poor-development-in-colorectal-cancer-by-modifying-hnrnpk-expression
#6
Tianyi Gao, Xiangxiang Liu, Bangshun He, Zhenlin Nie, Chengbin Zhu, Pei Zhang, Shukui Wang
Background: Exosomes mediated transfer of lncRNA 91H may play a critical role in the development of CRC. However, few studies have proved the mechanism. So we performed this study to deeply explore the biological functions of exosomal 91H in the development and progression of CRC. Methods: The association between lncRNA 91H and exosomes was detected in vitro and vivo. Then RNA pulldown and RIP were used to detect how lncRNA 91H affect CRC IGF2 express. At last, clinic pathological significance of exosomal 91H was evaluated by Cox proportional hazards model...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29374362/the-regulatory-network-analysis-of-long-noncoding-rnas-in-human-colorectal-cancer
#7
Yuwei Zhang, Yang Tao, Yang Li, Jinshun Zhao, Lina Zhang, Xiaohong Zhang, Changzheng Dong, Yangyang Xie, Xiaoyu Dai, Xinjun Zhang, Qi Liao
Colorectal cancer (CRC) is among one of the most prevalent and lethiferous diseases worldwide. Long noncoding RNAs (lncRNAs) are commonly accepted to function as a key regulatory factor in human cancer, but the potential regulatory mechanisms of CRC-associated lncRNA are largely obscure. Here, we integrated several expression profiles to obtain 55 differentially expressed (DE) lncRNAs. We first detected lncRNA interactions with transcription factors, microRNAs, mRNAs, and RNA-binding proteins to construct a regulatory network and then create functional enrichment analyses for them using bioinformatics approaches...
January 26, 2018: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/29364477/long-non-coding-rna-dleu7-as1-promotes-the-occurrence-and-development-of-colorectal-cancer-via-wnt-%C3%AE-catenin-pathway
#8
X-B Liu, C Han, C-Z Sun
OBJECTIVE:   To investigate the expression features of long non-coding RNA (lncRNA) DLEU7-AS1 in colorectal cancer (CRC), so as to further study its role in the occurrence and development of CRC and its potential regulatory mechanism. PATIENTS AND METHODS: The expression levels of lncRNA DLEU7-AS1 in 82 pairs of CRC tissues and para-carcinoma normal tissues were detected via quantitative Real-time polymerase chain reaction (qRT-PCR), and the correlation of DLEU7-AS1 expression with pathological indexes of CRC and patients' prognosis was analyzed...
January 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29345294/hypoxia-stimulates-the-cytoplasmic-localization-of-oncogenic-long-noncoding-rna-linc00152-in-colorectal-cancer
#9
Yujiro Nishizawa, Masamitsu Konno, Ayumu Asai, Jun Koseki, Koichi Kawamoto, Norikatsu Miyoshi, Hidekazu Takahashi, Naohiro Nishida, Naotsugu Haraguchi, Daisuke Sakai, Toshihiro Kudo, Taishi Hata, Chu Matsuda, Tsunekazu Mizushima, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii
Recent studies have indicated that long noncoding RNAs (lncRNAs) play a pivotal role in almost all physiological cellular processes, including every stage of cancer development. Given that hypoxia in the tumor microenvironment is involved in the malignant behavior of tumors, such as invasion and metastasis, we investigated the cytoplasmic and nuclear localization of lncRNAs in colorectal cancer cells. A cell culture under hypoxic conditions revealed several lncRNAs, such as LINC00152, whose levels were increased in the cytoplasm of colorectal cancer cells...
February 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29344178/long-non-coding-rna-lnctcf7-activates-the-wnt-%C3%AE-catenin-pathway-to-promote-metastasis-and-invasion-in-colorectal-cancer
#10
Tengyu Li, Jing Zhu, Xin Wang, Guowei Chen, Lie Sun, Shuai Zuo, Junling Zhang, Shanwen Chen, Ju Ma, Zihao Yao, Youwen Zheng, Zeyang Chen, Yucun Liu, Pengyuan Wang
Long non-coding RNA (Lnc)TCF7 is a novel lncRNA that is involved in tumorigenesis. Previous studies have revealed that lncTCF7 serves an essential role in maintaining cancer stem cell self-renewal; however, the functions of lncTCF7 in colorectal cancer (CRC) remain unknown. Therefore, the present study aimed to investigate the role of lncTCF7 in CRC. LncTCF7 was upregulated in 52/58 CRC tissues, and its expression correlated with tumor size, lymph metastasis and tumor-node-metastasis stage in CRC. Knocking down lncTCF7 in colon cancer cell lines decreased cell proliferation, migration and invasion, while lncTCF7 overexpression showed opposite changes...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29340086/up-regulation-of-lncrna-snhg1-indicates-poor-prognosis-and-promotes-cell-proliferation-and-metastasis-of-colorectal-cancer-by-activation-of-the-wnt-%C3%AE-catenin-signaling-pathway
#11
Yuping Zhu, Bo Li, Zhuo Liu, Lai Jiang, Gang Wang, Min Lv, Dechuan Li
Recently, the lncRNA small nucleolar RNA host gene (SNHG1) has been exhibited to be upregulated, which plays a crucial role in the development and prognosis of several cancers. However, the role of the biology and clinical significance of SNHG1 in the tumorigenesis of colorectal cancer (CRC) has rarely been reported. In this work, we firstly found that SNHG1 expression levels were upregulated aberrantly in colorectal cancer tissues and colorectal cancer cell lines. By Kaplan-Meier survival analysis, patients with high SNHG1 expression level had poorer overall survival (OS) and progression-free survival (PFS) than those with low SNHG1 expression...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29338818/expression-and-function-of-long-non-coding-rna-casc19-in-colorectal-cancer
#12
Jian Jun Wang, Xiao Min Li, Lei He, Shu Zhi Zhong, Yan Xiao Peng, Na Ji
Objective To investigate the expression, function and significance of long non-coding RNA (lncRNA) CASC19 in colorectal cancer (CRC). Methods Real-time quantitative polymerase chain reaction was employed to determine the expression of CASC19 in 40 paired samples from CRC surgical specimens and 5 CRC cell lines. The correlations of CASC19 expression with clinicopathologic parameters were analyzed. Transwell assay was applied to detect the migration ability of CRC cells after the CASC19 expression was knocked down by small interfering RNA...
December 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29330370/a-rna-sequencing-approach-for-the-identification-of-novel-long-non-coding-rna-biomarkers-in-colorectal-cancer
#13
Atsushi Yamada, Pingjian Yu, Wei Lin, Yoshinaga Okugawa, C Richard Boland, Ajay Goel
Long non-coding RNAs (lncRNAs) have been implicated in human pathology, however, their role in colorectal carcinogenesis have not been fully elucidated. In the current study, whole-transcriptome analysis was performed in 3 pairs of colorectal cancer (CRC) and matched normal mucosa (NM) by RNA sequencing (RNA-seq). Followed by confirmation using the Cancer Genome Atlas (TCGA) dataset, we identified 27 up-regulated and 22 down-regulated lncRNAs in CRC. Up-regulation of four lncRNAs, hereby named colorectal cancer associated lncRNA (CRCAL)-1 [AC021218...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29328404/chronic-oxymatrine-treatment-induces-resistance-and-epithelial%C3%A2-mesenchymal-transition-through-targeting-the-long-non-coding-rna-malat1-in-colorectal-cancer-cells
#14
Yibai Xiong, Jun Wang, Huirong Zhu, Lingshuang Liu, Yi Jiang
A major reason for colorectal cancer (CRC) chemoresistance is the enhanced migration and invasion of cancer cells, such as the cell acquisition of epithelial-mesenchymal transition (EMT). Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been considered as a pro-oncogene in multiple cancers. However, the precise functional mechanism of lncRNA MALAT1 in chemoresistance and EMT is not well known. In the present study, we focused on the effect of oxymatrine on CRC cells and further investigated the role of MALAT1 in oxymatrine-induced resistance and EMT process...
January 10, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29306015/long-noncoding-rnas-undeciphered-cellular-codes-encrypting-keys-of-colorectal-cancer-pathogenesis
#15
Taewan Kim, Carlo M Croce
Long noncoding RNAs are non-protein coding transcripts longer than 200 nucleotides in length. By the advance in genetic and bioinformatic technologies, the new genomic landscape including noncoding transcripts has been revealed. Despite their non-capacity to be translated into proteins, lncRNAs have a versatile functions through various mechanisms interacting with other cellular molecules including DNA, protein, and RNA. Recent research interest and endeavor have identified the functional role of lncRNAs in various diseases including cancer...
January 3, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29299168/lncrna-crnde-promotes-cell-proliferation-invasion-and-migration-by-competitively-binding-mir-384-in-papillary-thyroid-cancer
#16
Honggang Sun, Liqin He, Lan Ma, Tao Lu, Jianguo Wei, Kejie Xie, Xingmu Wang
Thyroid cancer is one of the most prevalent endocrine neoplasm. The present study examined the effects of Colorectal Neoplasia Differentially Expressed (CRNDE) on the progression of papillary thyroid cancer (PTC), and explored the underlying molecular mechanisms. Quantitative real-time PCR was used to detect CRNDE, miR-384 and pleiotrophin (PTN) mRNA expression. Western blot was used to measure PTN protein levels. Cell proliferation, cell growth, cell invasion and migration of PTC cells were determined by CCK-8, colony formation, transwell invasion and migration assays, respectively...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29286182/knockdown-of-pseudogene-derived-from-lncrna-duxap10-inhibits-cell-proliferation-migration-invasion-and-promotes-apoptosis-in-pancreatic-cancer
#17
Yifan Lian, Chuanxing Xiao, Changsheng Yan, Dajun Chen, Qingwen Huang, Yanyun Fan, Zhaohua Li, Hongzhi Xu
Current evidence suggests that pseudogene derived lncRNAs may be important players in human cancer progression. Our previous study showed that DUXAP10 could promote cell proliferation in colorectal cancer. However, the clinical significance and potential role of DUXAP10 in human pancreatic cancer (PC) has not been uncovered. In this study, we found that DUXAP10 was overexpressed in PC tissues compared with normal tissues. DUXAP10 expression was significantly higher in patients with an advanced TNM stage and positive lymph node metastasis...
December 29, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29278853/lncrna-hif1a-as2-positively-affects-the-progression-and-emt-formation-of-colorectal-cancer-through-regulating-mir-129-5p-and-dnmt3a
#18
Jinguan Lin, Zhaohui Shi, Zhiyuan Yu, Zhe He
LncRNAs were a group of RNAs, which can be a regulator or master in biological activities of cancer cells. HIF1A-AS2 belongs to this group, and it has been verified to be able to affect cell activities in several kinds of cancers. In this study, we tried to study the functions of HIF1A-AS2 exerted in colorectal cancer. In order to clearly know about the expression of HIF1A-AS2, miR-129-5p and DNMT3A in CRC tissues and cells, we employed qRT-PCR. The relevance among those three genes was examined by the use of Pearson correlation analysis...
December 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29274585/knockdown-of-the-long-non-coding-rna-hottip-inhibits-colorectal-cancer-cell-proliferation-and-migration-and-induces-apoptosis-by-targeting-sgk1
#19
Tianyou Liu, Tao Yu, Haiying Hu, Keping He
More and more long non-coding RNA (lncRNA) might be serve as molecular biomarkers for tumor cell progression. HOTTIP has been recently revealed as oncogenic regulator in several cancers. However, it remains unclear about whether and how HOTTIP regulates Colorectal cancer (CRC). In the present study, we assayed the expression of HOTTIP in CRC tissues and cell lines, and detected CRC cells (HCT-116 and SW620) proliferation, migration, and apoptosis when HOTTIP was knocked down. Furthermore, we discovered the underlying mechanism...
December 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29260518/-effects-of-lncrna-h19-on-proliferation-of-human-colorectal-cancer-sw620-cells
#20
Xiao-Lei Huo, Zhen Pei, Yong-Zhi Li, Ling-Na Han, Xiang-Yang Tian, Yi-Qiang Zhang
OBJECTIVE: To determine the expression level of long non-coding RNA (lncRNA) imprinted maternallyexpressed transcript (H19) in colorectal cancer tissues and its effect on proliferation of colorectal cancer SW620 cells. METHODS: Real-time quantitative PCR (qRT-PCR) was applied to detect the expression of H19 in 20 paired tumor tissues and adjacent normal tissues,and in normal NCM460 cells and colorectal cancer SW480,HCT116 and SW620 cells. The specific small interfering RNA for H19 (si-H19 group) or negative control sequence (si-NC group) were transfected into SW620 cells...
November 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
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