Remco de Bree, Lisa van der Putten, Harm van Tinteren, Jan Wedman, Wim J G Oyen, Luuk M Janssen, Michiel W M van den Brekel, Emile F I Comans, Jan Pruim, Robert P Takes, Monique G G Hobbelink, Renato Valdés Olmos, Bernard F A M van der Laan, Maarten Boers, Otto S Hoekstra, C René Leemans
PURPOSE: The purpose of this study is to evaluate the efficacy of (18)F-FDG-PET as first-line diagnostic investigation, prior to performing a direct laryngoscopy with biopsy under general anesthesia, in patients suspected of recurrent laryngeal carcinoma after radiotherapy. PATIENTS AND METHODS: 150 patients suspected of recurrent T2-4 laryngeal carcinoma at least two months after prior (chemo)radiotherapy with curative intent for resectable disease were randomized to direct laryngoscopy (CWU: conventional workup strategy) or to (18)F-FDG-PET only followed by direct laryngoscopy if PET was assessed 'positive' or 'equivocal' (PWU: PET based workup strategy), to compare the effectiveness of these strategies...
February 2016: Radiotherapy and Oncology