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Percutaneous mitral annuloplasty

Vasilis C Babaliaros, Adam B Greenbaum, Jaffar M Khan, Toby Rogers, Dee Dee Wang, Marvin H Eng, William W O'Neill, Gaetano Paone, Vinod H Thourani, Stamatios Lerakis, Dennis W Kim, Marcus Y Chen, Robert J Lederman
OBJECTIVES: This study sought to use a new catheter technique to split the anterior mitral valve leaflet (AML) and prevent iatrogenic left ventricular outflow tract (LVOT) obstruction immediately before transcatheter mitral valve replacement (TMVR). BACKGROUND: LVOT obstruction is a life-threatening complication of TMVR, caused by septal displacement of the AML. METHODS: The procedure was used in patients with severe mitral valve disease and prohibitive surgical risk...
April 24, 2017: JACC. Cardiovascular Interventions
Dorothee H L Bail
OBJECTIVE: The purpose of this study is to provide a systematic review of currently available data about the percutaneous trans-coronary-venous mitral annuloplasty with the Carillon Mitral Contour System. METHOD: A systematic literature search was conducted using the common medical and scientific databases. The documented parameters included among others grade of mitral regurgitation (MR), vena contracta (VC), effective regurgitant orifice area (EROA), 6 minute-walk-test (6MWT), NYHA-classification, and Quality of Life (QoL) at baseline, 30 days and in the long-term follow-up...
April 2017: Journal of Interventional Cardiology
Horst Sievert, Steven Goldberg, Tomasz Siminiak, Hubertus Degen, Janusz Lipiecki, Michael Haude
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
Horst Sievert, Michael Haude, Hubertus Degen, Janusz Lipiecki, Steven Goldberg, Tomasz Siminiak
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
Maurizio Taramasso, Azeem Latib
Percutaneous mitral valve therapies are emerging as an alternative option for high-risk patients who are not good candidates for conventional open-heart surgery. Recently, multiple technologies and diversified approaches have been developed and are under clinical study or in preclinical development. This article on transcatheter mitral annuloplasty devices, describes the different technologies, and reports on the initial clinical and preclinical experiences.
January 2016: Interventional cardiology clinics
Piotr Kałmucki, Olga Jerzykowska, Rafał Dankowski, Artur Baszko, Lucyna Kramer, Andrzej Szyszka, Tomasz Siminiak
OBJECTIVES: The purpose of our study is to verify, whether percutaneous mitral annuloplasty results in reverse remodeling in patients with functional mitral regurgitation (FMR) and impaired ejection fraction (EF) and to investigate which echo parameters may help in prediction of the efficacy of the procedure. BACKGROUND: FMR exacerbates left ventricular (LV) dilatation and contributes to both LV remodeling and heart failure. METHODS: We analyzed baseline and 1 month follow-up data in 22 consecutive patients with FMR, who underwent successful percutaneous trans-coronary venous mitral annuloplasty with the Carillon device...
December 2016: Journal of Interventional Cardiology
Rawn Salenger, Xavier Diao, Murtaza Y Dawood, Daniel L Herr, George A Sample, Augusto Pichard, James S Gammie
We report a case of catastrophic hemodynamic compromise secondary to pannus ingrowth and severe mitral stenosis occurring years after repair of a nonrheumatic mitral valve. The initial repair included closure of a posterior leaflet cleft and implantation of an annuloplasty ring. We describe a hybrid treatment strategy for this severely compromised patient, which included initial placement of a right ventricular assist device followed by percutaneous balloon mitral valvuloplasty and, eventually, a definitive mitral valve reoperation...
November 2016: Annals of Thoracic Surgery
Georg Nickenig, Christoph Hammerstingl, Robert Schueler, Yan Topilsky, Paul A Grayburn, Alec Vahanian, David Messika-Zeitoun, Marina Urena Alcazar, Stephan Baldus, Rudolph Volker, Michael Huntgeburth, Ottavio Alfieri, Azeem Latib, Giovanni La Canna, Eustachio Agricola, Antonio Colombo, Karl-Heinz Kuck, Felix Kreidel, Christian Frerker, Felix C Tanner, Ori Ben-Yehuda, Francesco Maisano
OBJECTIVES: This study sought to show safety and efficacy of the Cardioband system during 6 months after treatment. BACKGROUND: Current surgical and medical treatment options for functional mitral regurgitation (FMR) are limited. The Cardioband system (Valtech Cardio, OrYehuda, Israel) is a novel transvenous, transseptal direct annuloplasty device. METHODS: Thirty-one patients (71.8 ± 6.9 years of age; 83.9% male; EuroSCORE II: 8.6 ± 5.9) with moderate to severe FMR, symptomatic heart failure, and depressed left ventricular function (left ventricular ejection fraction 34 ± 11%) were prospectively enrolled...
October 10, 2016: JACC. Cardiovascular Interventions
Ted Feldman, Mayra Guerrero, Michael H Salinger
No abstract text is available yet for this article.
September 18, 2016: EuroIntervention
Azeem Latib, Marco B Ancona, Luca Ferri, Matteo Montorfano, Antonio Mangieri, Damiano Regazzoli, Francesco Giannini, Fabrizio Monaco, Manuela Giglio, Stefano De Servi, Ottavio Alfieri, Antonio Colombo, Eustachio Agricola
No abstract text is available yet for this article.
September 26, 2016: JACC. Cardiovascular Interventions
Nagwa Abdelrahman, Mohammed Andaleeb Chowdhury, Arif Al Nooryani, Wael Elabbassi
Functional mitral regurgitation (FMR) is common in severe heart failure. Medical therapy is the standard of care since the role of surgery is less established. Various trans-catheter percutaneous techniques may avoid the risks of surgery; such as edge-to-edge repair using MitraClip system (Abbott Vascular, Illinois, USA) and CARILLON® Mitral Contour System® (Model XE2; Cardiac Dimensions., Kirkland, WA, USA). We present the case of a 41-year-old man with severe dilated cardiomyopathy, NYHA IIIb, and grade 3 MR...
December 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Janusz Lipiecki, Tomasz Siminiak, Horst Sievert, Jochen Müller-Ehmsen, Hubertus Degen, Justina C Wu, Christian Schandrin, Piotr Kalmucki, Ilona Hofmann, David Reuter, Steven L Goldberg, Michael Haude
OBJECTIVE: Functional (or secondary) mitral regurgitation (FMR) is associated with greater morbidity and worse outcomes in patients with congestive heart failure (CHF) and cardiomyopathy. The Carillon® Mitral Contour System® is a coronary sinus-based percutaneous therapy to reduce FMR. We evaluated the safety and efficacy of a modified version of the Carillon device in the treatment of patients with cardiomyopathy and FMR. METHODS: 36 patients with CHF, depressed left ventricular function (ejection fraction <40%) and at least moderate FMR underwent the Carillon device implant...
2016: Open Heart
Georg Nickenig, Robert Schueler, Antonio Dager, Pedro Martinez Clark, Alexandre Abizaid, Tomasz Siminiak, Pawel Buszman, Marcin Demkow, Adrian Ebner, Federico M Asch, Christoph Hammerstingl
BACKGROUND: Current surgical and medical treatment options for functional mitral regurgitation (FMR) are limited and additional interventional approaches are required. OBJECTIVES: This study sought to report the safety and performance data from the feasibility study with a novel direct annuloplasty system. METHODS: Seventy-one patients with moderate to severe FMR (mean 67.7 ± 11.3 years of age, left ventricular [LV] ejection fraction 34.0 ± 8...
June 28, 2016: Journal of the American College of Cardiology
Arpandeep Randhawa, Abhimanyu Saini, Anjali Aggarwal, Uma Nahar Saikia, R Shane Tubbs, Tulika Gupta, Manoj Kumar Rohit, Gurdeep Singh Kalyan, Daisy Sahni
BACKGROUND: The spatial relationship of the coronary sinus-great cardiac vein (CS-GCV) to free posterior portion of the mitral valve annulus (MVA) and left circumflex coronary artery (LCx) has gained importance with the advent of cardiovascular interventional procedures such as percutaneous transvenous mitral annuloplasty (PTMA) and mitral isthmus (MI) ablation. METHODS: In 50 normal (nondilated cardiomyopathy, or non-DCM) and 20 dilated cardiomyopathy (DCM) cadaveric hearts, the diameter and distance from the MVA of CS-GCV and its spatial relationship to LCx along the free posterior portion of the MVA were studied...
September 2016: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
Janice Swampillai
Percutaneous approaches to reduce mitral regurgitation in ischemic cardiomyopathy have stirred interest recently. Patients with ischemic cardiomyopathy and functional mitral regurgitation often meet criteria for cardiac resynchronisation therapy to improve left ventricular function as well as mitral regurgitation, and alleviate symptoms. This case shows that implantation of a pacing lead in the coronary sinus to restore synchronous left and right ventricular contraction is feasible, despite the presence of a remodeling device in the coronary sinus...
May 16, 2016: World Journal of Clinical Cases
Mackram F Eleid, Allison K Cabalka, Matthew R Williams, Brian K Whisenant, Oluseun O Alli, Neil Fam, Peter M Pollak, Firas Barrow, Joseph F Malouf, Rick A Nishimura, Lyle D Joyce, Joseph A Dearani, Charanjit S Rihal
OBJECTIVES: This study sought to examine the feasibility, safety, and intermediate-term outcomes in patients undergoing percutaneous transvenous transcatheter mitral valve implantation in failed bioprosthesis, ring annuloplasty, and calcific mitral stenosis. BACKGROUND: Surgical mitral valve replacement in patients with previous surgery or severe mitral annular calcification (MAC) is often associated with high or prohibitive risk. METHODS: Percutaneous transfemoral antegrade transseptal implantation of Edwards SAPIEN prosthesis (Edwards Lifesciences, Irvine, California) was performed in 48 patients with degenerated mitral bioprosthesis (n = 33), previous ring annuloplasty (n = 9), and severe MAC (n = 6)...
June 13, 2016: JACC. Cardiovascular Interventions
Lalit Mehra, Shashi Raheja, Sneh Agarwal, Yashoda Rani, Kulwinder Kaur, Anita Tuli
Percutaneous transvenous mitral annuloplasty (PTMA) has evolved as a latest procedure for the treatment of functional mitral regurgitation. It reduces mitral valve annulus (MVA) size and increases valve leaflet coaptation via compression of coronary sinus (CS). Anatomical considerations for this procedure were elucidated in the present study. In 40 formalin fixed adult cadaveric human hearts, relation of the venous channel formed by CS and great cardiac vein (GCV) to MVA and the adjacent arteries was described, at 6 points by making longitudinal sections perpendicular to the plane of MVA, numbered 1-6 starting from CS ostium...
March 2016: Anatomy & Cell Biology
Michele De Bonis, Elisabetta Lapenna, Nicola Buzzatti, Giovanni La Canna, Paolo Denti, Federico Pappalardo, Davide Schiavi, Alberto Pozzoli, Micaela Cioni, Giovanna Di Giannuario, Ottavio Alfieri
OBJECTIVES: Recurrent mitral regurgitation (MR) is common after surgical and percutaneous (MitraClip) treatment of functional MR (FMR). However, the Everest II trial suggested that, in patients with secondary MR and initially successful MitraClip therapy, the results were sustained at 4 years and were comparable with surgery in terms of late efficacy. The aim of this study was to assess whether both those findings were confirmed by our own experience. METHODS: We reviewed 143 patients who had an initial optimal result (residual MR ≤ 1+ at discharge) after MitraClip therapy (85 patients) or surgical edge-to-edge (EE) repair (58 patients) for severe secondary MR (mean ejection fraction 28 ± 8...
September 2016: European Journal of Cardio-thoracic Surgery
Yuval Ramot, Serge D Rousselle, Nadav Yellin, Udi Willenz, Itai Sabag, Avi Avner, Abraham Nyska
Prosthetic annuloplasty rings are a common treatment modality for mitral regurgitation, and recently, percutaneous implantation techniques have gained popularity due to their favorable safety profile. Although in common use, biocompatibility of annuloplasty rings has been reported only sparsely in the literature, and none of these reports used the percutaneous technique of implantation. We report on the biocompatibility and the systemic safety of a novel transcatheter mitral valve annuloplasty ring (AMEND™) in 6 minipigs...
July 2016: Toxicologic Pathology
Cengiz Ozturk, Atila Iyisoy, Ersel Onrat, Sevket Balta, Turgay Celik
No abstract text is available yet for this article.
April 15, 2016: International Journal of Cardiology
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