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https://www.readbyqxmd.com/read/28632410/correlation-between-interleukin-6-and-thrombin-antithrombin-iii-complex-levels-in-retinal-diseases
#1
Rita Ehrlich, Alon Zahavi, Ruth Axer-Siegel, Ivan Budnik, Ayelet Dreznik, Mor Dahbash, Yael Nisgav, Elinor Megiddo, Gili Kenet, Dov Weinberger, Tami Livnat
PURPOSE: This study aims to evaluate and correlate the levels of interleukin-6 (IL-6) and thrombin-antithrombin III complex (TAT) in the vitreous of patients with different vitreoretinal pathologies. METHODS: Vitreous samples were collected from 78 patients scheduled for pars plana vitrectomy at a tertiary medical center. Patients were divided by the underlying vitreoretinal pathophysiology, as follows: macular hole (MH)/epiretinal membrane (ERM) (n = 26); rhegmatogenous retinal detachment (RRD) (n = 32); and proliferative diabetic retinopathy (PDR) (n = 20)...
June 20, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28630788/evaluation-of-ganglion-cell-inner-plexiform-layer-thickness-after-vitreoretinal-surgery-with-internal-limiting-membrane-peeling-in-cases-with-idiopathic-macular-hole
#2
Sibel Demirel, Ahmed Abdullayev, Özge Yanık, Figen Batıoğlu, Emin Özmert
OBJECTIVES: To evaluate macular retinal ganglion cell-inner plexiform layer (GCIPL) thickness after vitrectomy with internal limiting membrane (ILM) peeling for idiopathic macular holes using spectral domain optical coherence tomography (SD-OCT). MATERIALS AND METHODS: Eighteen eyes of 18 patients with unilateral idiopathic macular hole who underwent vitrectomy with ILM peeling were retrospectively analyzed. Healthy fellow eyes of the patients and 18 eyes of 18 age-matched healthy individuals constituted the control group...
June 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28613215/correlation-between-preoperative-en-face-optical-coherence-tomography-of-photoreceptor-layer-and-visual-prognosis-after-macular-hole-surgery
#3
Kiyoung Kim, Eung Suk Kim, Yonguk Kim, Seung-Young Yu, Hyung Woo Kwak
PURPOSE: To investigate the correlation between preoperative en face spectral domain optical coherence tomography findings of the photoreceptor layer with restoration of foveal microstructure and visual acuity in repaired macular holes. METHODS: Medical records of 106 patients with surgically closed macular holes were retrospectively reviewed. Preoperative OCT slabs of the external limiting membrane (ELM) and ellipsoid zone (EZ) were generated using embedded tools...
May 22, 2017: Retina
https://www.readbyqxmd.com/read/28611650/anterior-360%C3%A2-synechiolysis-in-a-case-of-late-iridocorneal-adhesions-after-25-g-vitrectomy-surgical-and-physiopathogenetic-aspects
#4
Raffaele Nuzzi, Francesca Monteu
We describe the case of an 86-year-old patient, pseudophakic in both eyes and with high myopia, who had previously had a 25-G vitrectomy with 20% C3F8 used as a tamponade due to a total retinal detachment with choroidal hemorrhages and macular hole. At the postoperative 4-month follow-up, we found 360° iridocorneal synechiae with elevated intraocular pressure due to angle closure in all sectors, with an adherent retina and in the absence of choroidal hemorrhage/detachment and of corneal edema or endothelial damage...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28610601/positioning-in-macular-hole-surgery-pims-statistical-analysis-plan-for-a-randomised-controlled-trial
#5
Lauren Bell, Richard Hooper, Catey Bunce, Saruban Pasu, James Bainbridge
BACKGROUND: The treatment of idiopathic full-thickness macular holes involves surgery to close the hole. Some surgeons advise patients to adopt a face-down position to increase the likelihood of successful macular hole closure. However, patients often find the face-down positioning arduous. There is a lack of conclusive evidence that face-down positioning improves the outcome. The 'Positioning In Macular hole Surgery' (PIMS) trial will assess whether advice to position face-down after surgery improves the surgical success rate for the closure of large (≥400 μm) macular holes...
June 13, 2017: Trials
https://www.readbyqxmd.com/read/28604979/femtosecond-laser-assisted-cataract-in-vitreoretinal-surgery
#6
Stanislao Rizzo, Daniela Bacherini, Francesco Faraldi, Marco Pellegrini, Cesare Mariotti
PURPOSE: To assess the safety and surgical results of femtosecond laser-assisted phacovitrectomy. METHODS: Fifteen patients over 50 years of age with coexisting vitreoretinal pathologies and cataract underwent combined femtosecond laser-assisted cataract extraction and sutureless 25-G and 27-G vitreoretinal surgery. RESULTS: The indication for surgery was macular hole in 6 patients, epiretinal membrane in 6, vitreous hemorrhage in 2, and retinal detachment in 1...
June 2, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28603410/full-thickness-macular-hole-formation-following-anti-vegf-injections-for-neovascular-age-related-macular-degeneration
#7
Stamatina A Kabanarou, Tina Xirou, George Mangouritsas, Christina Garnavou-Xirou, Eirini Boutouri, Ilias Gkizis, Irini Chatziralli
PURPOSE: Macular hole (MH) is part of a group of age-related degenerative diseases characterized by pathology of vitreomacular interface. Similarly, neovascular age-related macular degeneration (nAMD) affects older patients and is a leading cause of irreversible visual loss. The purpose of this case series is to describe the development of full-thickness MH in patients with nAMD, following antivascular endothelial growth factor (anti-VEGF) treatment. METHODS: Participants in this case series were four patients with nAMD, who received anti-VEGF injections with variable therapeutic response to treatment...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28590964/overview-of-the-complications-of-high-myopia
#8
Yasushi Ikuno
High myopia is very common and one of the major causes of social blindness, especially in East Asian countries. It is characterized by axial length elongation, and induces various specific complications, including cataract formation, retinal detachment from peripheral retinal tears, myopic foveoschisis, macular hole with or without retinal detachment, peripapillary deformation, dome-shaped macula, choroidal/scleral thinning, myopic choroidal neovascularization, and glaucoma. This article will review these complications and discuss the current concepts relating to these complications and their treatments...
January 24, 2017: Retina
https://www.readbyqxmd.com/read/28590319/surgical-outcomes-of-27-gauge-vitrectomy-for-a-consecutive-series-of-163-eyes-with-various-vitreous-diseases
#9
Kazuhito Yoneda, Keisuke Morikawa, Yusuke Oshima, Shigeru Kinoshita, Chie Sotozono
PURPOSE: To evaluate the safety and efficacy of 27-gauge vitrectomy for various vitreoretinal disorders. METHODS: In this retrospective comparative study, 163 consecutive eyes with various diseases that underwent 27-gauge pars plana vitrectomy with or without ultraspeed transformer by a single surgeon from June 2012 through December 2014 were analyzed in regard to best-corrected visual acuity, intraocular pressure, intraoperative and postoperative complications, and surgery time...
January 4, 2017: Retina
https://www.readbyqxmd.com/read/28576209/vegf-a-is-increased-in-exogenous-endophthalmitis
#10
Mark E Seamone, Darrell R Lewis, Ian D Haidl, R Rishi Gupta, Daniel M O' Brien, John Dickinson, Arif Samad, Jean S Marshall, Alan F Cruess
OBJECTIVE: Exogenous endophthalmitis is an ophthalmologic emergency defined by panocular inflammation. Vascular endothelial growth factor A (VEGF-A) contributes to inflammation by promoting chemotaxis of monocytes and granulocytes and by increasing vascular permeability. The purpose of this article is to determine if VEGF-A is elevated in the vitreous samples obtained from individuals with exogenous endophthalmitis. METHODS: Vitreous samples from individuals with exogenous endophthalmitis (n = 18) were analyzed via Luminex assay and enzyme-linked immunosorbent assay for the cytokines VEGF-A, tumor necrosis factor (TNF), interleukin 6 (IL-6), IL-8 (chemokine [CXCL]-8), IL-1β, IL-10, IL-12p70, IL-33, interferon (IFN)-γ, IFN-α, IFN-β, chemokine ligand (CCL)-3, IL-2, IL-5, IL-15, CXCL-10, CCL-2, IL-1Ra, CCL-5, IL-17, and CCL-11...
June 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28572674/cytokine-profiling-in-the-sub-silicone-oil-fluid-after-vitrectomy-surgeries-for-refractory-retinal-diseases
#11
Hiroki Kaneko, Kei Takayama, Tetsu Asami, Yasuki Ito, Taichi Tsunekawa, Takeshi Iwase, Yasuhito Funahashi, Shinji Ueno, Norie Nonobe, Shunsuke Yasuda, Ayana Suzumura, Hideyuki Shimizu, Reona Kimoto, Shiang-Jyi Hwang, Hiroko Terasaki
Silicone oil (SO) is an intraocular surgical adjuvant that reduces the surgical complications in refractory retinal diseases, although membrane and cellular proliferation is often seen even in SO-filled eyes. We hypothesised that the fluid in the space between the SO and the retina, named the "sub-silicone oil fluid (SOF)", enhances these biological responses. We proposed a safe method for SOF extraction. We also analysed inflammatory cytokine expressions and SOF osmotic pressures from eyes with rhegmatogenous retinal detachment (RRD), proliferative diabetic retinopathy (PDR), proliferative vitreoretinopathy (PVR) and macular hole-associated retinal detachment (MHRD)...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28571008/microrna-200b-expression-in-the-vitreous-humor-of-patients-with-proliferative-diabetic-retinopathy
#12
Amir Ramadan Gomaa, Eman Tayae Elsayed, Reham Fadl Moftah
BACKGROUND: The role of microRNA (miRNA)-200b in the pathogenesis of proliferative diabetic retinopathy (PDR) has been studied in diabetic animal models. The aim of this study was to assess miRNA-200b expression in the vitreous of patients with PDR and to determine its correlation with vascular endothelial growth factor (VEGF), one of the pathogenic mechanisms in PDR. METHODS: Quantitative reverse transcription polymerase chain reaction was used to measure miRNA-200b expression in the vitreous from 29 eyes with PDR and 30 eyes with idiopathic macular holes (IMH; control group)...
June 2, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28570483/the-efficacy-of-superior-inverted-internal-limiting-membrane-flap-technique-for-the-treatment-of-full-thickness-macular-hole
#13
Se Rang Choi, Joon Won Kang, Ji Hoon Jeon, Joo Young Shin, Bum-Joo Cho, Baek-Lok Oh, Jang Won Heo
No abstract text is available yet for this article.
May 29, 2017: Retina
https://www.readbyqxmd.com/read/28559725/green-laser-induced-foveal-cyst-sustained-in-a-recreational-laser-light-show
#14
Rukiye Aydin, Merve Ozbek, Mustafa Ozsutcu, Fevzi Senturk
We report the case of a 9-year-old boy complained of visual loss in his right eye after watching green laser light show being hit by a ray of a laser at shopping center before five days ago. The laser had a maximum power rating of 30 mW (US Food and Drug Administration class IIIB). Best-corrected visual acuity in his right eye was 0.2 with Snellen at 5 days after the injury. Dilated fundoscopic examination demonstrated a macular hole appearance in the right eye. Spectral domain optical coherence tomography (OCT, Spectralis, Heidelberg Engineering, Heidelberg, Germany) demonstrates a steep fovea contour, a thickening of the macular edges, intraretinal cysts, disruption of the photoreceptor inner segment/outer segment layer and macular pseudohole formation...
April 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28546696/new-surgical-technique-for-management-of-recurrent-macular-hole
#15
Osman Abdelzaher Mohammed, Anant Pai
Recurrence of macular hole (MH) following the standard approach of pars plana vitrectomy, posterior hyaloids removal, internal limiting membrane peeling, gas tamponade, and postoperative positioning is a common postoperative complication following MH surgery. We present a new surgical technique which involves induction of serous macular detachment around the MH, parafoveal retinal massage to bring its edges closer, gas tamponade, and face down positioning. The recurrent MHs had closed in all four consecutive patients with a parallel gain in visual acuity following this technique...
January 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546149/progression-of-lamellar-hole-associated-epiretinal-proliferation-and-retinal-changes-during-long-term-follow-up
#16
Denise Compera, Ricarda G Schumann, Matteo G Cereda, Alessandra Acquistapace, Viviane Lita, Siegfried G Priglinger, Giovanni Staurenghi, Ferdinando Bottoni
PURPOSE: To report on progression of lamellar hole-associated epiretinal proliferation (LHEP) in eyes with lamellar macular holes (LMH) using spectral-domain optical coherence tomography (SD-OCT), and to correlate with intraretinal changes and visual function. METHODS: From a retrospectively reviewed series of 167 eyes with non-full-thickness macular holes, we exclusively included a subgroup of 34 eyes with LMH and LHEP by SD-OCT evaluation. In these eyes, area of LHEP, intraretinal changes of defect diameter, central retinal thickness, defects of the ellipsoid zone and occurrence of a contractive epiretinal membrane were analysed...
May 25, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28542230/visual-field-changes-after-vitrectomy-with-internal-limiting-membrane-peeling-for-epiretinal-membrane-or-macular-hole-in-glaucomatous-eyes
#17
Shunsuke Tsuchiya, Tomomi Higashide, Kazuhisa Sugiyama
PURPOSE: To investigate visual field changes after vitrectomy for macular diseases in glaucomatous eyes. METHODS: A retrospective review of 54 eyes from 54 patients with glaucoma, who underwent vitrectomy for epiretinal membrane (ERM; 42 eyes) or macular hole (MH; 12 eyes). Standard automated perimetry (Humphrey visual field 24-2 program) was performed and analyzed preoperatively and twice postoperatively (1st and 2nd sessions; 4.7 ± 2.5, 10.3 ± 3.7 months after surgery, respectively)...
2017: PloS One
https://www.readbyqxmd.com/read/28538264/lamellar-hole-associated-epiretinal-proliferation-in-lamellar-macular-hole-and-full-thickness-macular-hole-in-high-myopia
#18
Tso-Ting Lai, Chung-May Yang
PURPOSE: To report findings and surgical outcomes of lamellar macular hole (LMH) or full-thickness macular hole (FTMH) accompanied by lamellar hole-associated epiretinal proliferation (LHEP) in eyes with high myopia (HM). METHODS: Consecutive cases of HM with LMH or FTMH containing LHEP were retrospectively reviewed (study group, 43 cases). Cases of HM without LHEP (22) and those of non-HM with LHEP (30) served as Control A and B. RESULTS: The study group showed larger (928...
May 18, 2017: Retina
https://www.readbyqxmd.com/read/28499053/a-modified-perfluoro-n-octane-assisted-autologous-internal-limiting-membrane-transplant-for-failed-macular-hole-reintervention-a-case-series
#19
Sengul Ozdek, Prabu Baskaran, Levent Karabas, Pedro Pereira Neves
The authors describe a modified perfluoro-n-octane (PFO)-assisted autologous internal limiting membrane (ILM) transplantation technique for macular hole (MH) reintervention and present results from a series of 11 patients. The authors harvested a free ILM flap and transplanted it into the MH under a PFO bubble. The time at which PFO is injected, the extent of coverage of PFO, and the sequence of fluid-air exchange (FAE) are crucial to overcome previously described technical difficulties of relieving the flap from forceps, stabilizing the flap into the MH, and prevention of flap dislodgement during FAE...
May 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28499050/swept-source-oct-visualization-of-macular-hole-closure-in-gas-filled-eyes
#20
Daniel Q Li, Netan Choudhry
BACKGROUND AND OBJECTIVE: To assess the utility of swept-source optical coherence tomography (SS-OCT) in visualizing macular hole (MH) closure through gas-filled eyes on postoperative day (POD) 1 using a dual scanning protocol. PATIENTS AND METHODS: We examined 30 consecutive patients with full-thickness MH who underwent standard vitrectomy with SF6 (25%) gas tamponade between July 2015 and April 2016. SS-OCT imaging was performed using horizontal raster and 16-line radial scans with manual delicate focusing to evaluate MH closure status...
May 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
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