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Macular hole

Lydia Sauer, Sven Peters, Johanna Schmidt, Dietrich Schweitzer, Matthias Klemm, Lisa Ramm, Regine Augsten, Martin Hammer
PURPOSE: To investigate the impact of macular pigment (MP) on fundus autofluorescence (FAF) lifetimes in vivo by characterizing full-thickness idiopathic macular holes (MH) and macular pseudo-holes (MPH). METHODS: A total of 37 patients with MH and 52 with MPH were included. Using the fluorescence lifetime imaging ophthalmoscope (FLIO), based on a Heidelberg Engineering Spectralis system, a 30° retinal field was investigated. FAF decays were detected in a short (498-560 nm; ch1) and long (560-720 nm; ch2) wavelength channel...
October 24, 2016: Acta Ophthalmologica
L Porrúa, N Oblanca, J J González-López
CASE REPORT: A 14 year-old boy attended our clinic complaining of a scotoma after an accidental exposure to a 10W, 450nm laser beam from a blue-light handheld laser device. Optical coherence tomography confirmed a full thickness macular hole. As visual acuity (VA) remained 20/20 Snellen, observation was decided. Spontaneous closure was confirmed after one month. DISCUSSION: Reckless use of high-power handheld laser devices may induce severe retinal lesions, including full thickness macular holes...
October 18, 2016: Archivos de la Sociedad Española de Oftalmología
Marko Popovic, Varun Chaudhary, Bryon R McKay, Prima Moinul, Mohammad Mohaghagh, Anne Beattie, Mark Fava, Dalia Eino, Keith Mann, Lawrence Kobetz, Joshua Barbosa
OBJECTIVE: The purpose of this study was to investigate the extent of agreement between physicians and patients in reporting ocular history and to determine whether there are any predictive factors for physician-patient consensus. DESIGN: Retrospective chart review. PARTICIPANTS: Between June and September 2014, adult patients undergoing cataract surgery were recruited for the study. METHODS: Before surgery, patient demographics and self-reported ocular history were extracted from a prospectively collected database...
October 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Ryuya Hashimoto, Tetsuya Sugiyama, Makoto Ubuka, Takatoshi Maeno
PURPOSE: To investigate optic nerve head (ONH) blood flow changes resulting from intraocular pressure (IOP) elevation in subjects without systemic disorders. MATERIALS AND METHODS: Eighteen eyes of 18 patients who underwent vitrectomy to treat an epiretinal membrane or macular hole at Toho University Sakura Medical Center were included. Following standard 25-gauge microincision vitreous surgery, mean blur rate (MBR) in tissue (MT), an index of ONH blood flow, was measured using laser speckle flowgraphy...
October 21, 2016: Current Eye Research
Takehiro Matsumura, Yoshihiro Takamura, Takeshi Tomomatsu, Shogo Arimura, Makoto Gozawa, Akira Kobori, Masaru Inatani
PURPOSE: To evaluate the efficacy of the inverted internal limiting membrane (ILM) flap technique in vitrectomy for macular hole (MH) with retinal detachment (RD) compared with vitrectomy using ILM peeling. METHODS: A retrospective case series study was performed. Twenty-two eyes of 22 patients who underwent vitrectomy for MH with RD and followed-up more than 12 months after the surgery were included in this study. We retrospectively reviewed the medical records of patients who underwent vitrectomy with inverted ILM flap technique or vitrectomy with ILM peeling...
2016: PloS One
Haiying Jin, Qi Zhang, Peiquan Zhao
BACKGROUND: To introduce a modified surgical technique, the "parafoveal multiple curvelinear internal limiting membrane (ILM) peeling", to preserve epi-foveal ILM in myopic foveoschisis surgery. METHODS: Consecutive patients with myopic foveoschisis were enrolled in the present prospective interventional case series. The surgeries were performed using transconjunctival 23-gauge system. The macular area was divided into quadrants. ILM was peeled off in a curvilinear manner centered around the site that was away from the central fovea in each quadrant...
October 18, 2016: BMC Ophthalmology
Carlos A Medina, Angelica G Ortiz, Nidhi Relhan, William E Smiddy, Justin H Townsend, Harry W Flynn
PURPOSE: To report the clinical features, possible associations and treatment outcomes of patients with macular hole after pars plana vitrectomy (PPV) (single or multiple) for rhegmatogenous retinal detachment (RD). METHODS: Retrospective consecutive case series from July 2009 to July 2014. RESULTS: In the 15 study patients, the average time from RD surgery to macular hole diagnosis was 119 days (range: 41-398 months). Possible associations include epiretinal membrane (73%, 11/15 patients), macula-off RD (60%, 9/15 patients), recurrent RD (47%, 7/15 patients), and high myopia (56%, 5/9 patients)...
October 11, 2016: Retina
Kanako Yasuda, Ryosuke Motohashi, Osamu Kotake, Hayate Nakagawa, Hidetaka Noma, Masahiko Shimura
PURPOSE: To compare the effects of topical diclofenac and betamethasone on postoperative inflammation after combined sutureless cataract and vitreoretinal surgery in patients with macular hole (MH), epiretinal membrane (ERM), diabetic macular edema (DME), and rhegmatogenous retinal detachment (RRD). METHODS: The study involved 180 eligible eyes that underwent the combined surgery, followed by treatment with topical diclofenac (n = 100) or betamethasone (n = 80) for 12 weeks...
October 18, 2016: Journal of Ocular Pharmacology and Therapeutics
Ramesh Venkatesh, Prachi Gurav, Prachi A Dave
PURPOSE: To report a case of choroidal neovascular membrane after vitreoretinal surgery in a patient with macular hole-induced retinal detachment. METHODS: Retrospective observational case report. CASE DESCRIPTION: A 64-year-old lady presented with sudden drop in vision in the right eye since 20 days. Her best-corrected visual acuity was 6/36 in the right eye and 6/18 in the left eye. She was diagnosed with retinal detachment with a macular hole in the right eye...
October 3, 2016: Retinal Cases & Brief Reports
Robert A Sisk, Okan Toygar
Purpose. To introduce a clinical sign on spectral domain optical coherence tomography (SDOCT), which may indicate high risk for full-thickness macular hole formation after internal limiting membrane (ILM) peeling. Methods. The preoperative SDOCT images of two patients-one with multilaminar hemorrhage from ruptured retinal artery macroaneurysm and one with serous retinal detachment and severe macular schisis from optic pit maculopathy-who developed full-thickness macular hole (FTMH) after ILM peeling were evaluated retrospectively...
2016: Case Reports in Ophthalmological Medicine
Yuedong Hu, Liu Ningning, Yanyan Chen
We report a case of tamoxifen associated macular hole with typical optical imaging and clinical features. A 53-year-old woman came to our department for gradual decrees of vision acuity in both eyes for 3 months after 30 months low-dosage-tamoxifen treatment as adjuvant treatment for invasive ductal breast carcinoma. Her best corrected visual acuity (BCVA) was 0.4 in the right eye and 0.12 in the left eye. Dilated fundus examination showed macular multiple, fine, crystalline deposits and small white points in retina of both eyes...
October 13, 2016: Photodiagnosis and Photodynamic Therapy
Sayaka Myojin, Takeru Yoshimura, Shigeo Yoshida, Atsunobu Takeda, Yusuke Murakami, Yoichi Kawano, Yuji Oshima, Tatsuro Ishibashi, Koh-Hei Sonoda
PURPOSE: The analysis of gene expression in idiopathic epiretinal membranes (iERMs) may help elucidate ERM formation and its pathology. Here, we conducted a case-control study, in order to determine the expression levels of cytokines and other genes in eyes with macular hole (MH) or iERM. METHODS: Twenty eyes, obtained from seven male and 13 female patients, were included in the study. The average age of the study subjects was 69.1 ± 7.67 years, and 15 eyes had iERM, while five eyes had MH...
2016: PloS One
Elad Moisseiev, Glenn Yiu
We report the case of a 69-year-old patient who underwent vitrectomy for vitreomacular traction (VMT) and developed a postoperative macular hole that was observed 1 week after surgery. The hole did not close by in-office fluid-gas exchange alone, but was achieved after repeat surgery with internal limiting membrane (ILM) peeling. Intraoperative OCT (iOCT) images from the first surgery revealed an occult macular hole that formed after VMT release. We discuss how iOCT findings provide insight into the role of the ILM in macular hole formation and emphasize the importance of carefully inspecting iOCT images in real time to avoid missing small but important findings...
May 2016: Case Reports in Ophthalmology
Kazuyuki Kumagai, Akinori Uemura, Masanori Hangai, Tetsuyuki Suetsugu, Nobuchika Ogino
PURPOSE: To determine the effects of vitreomacular separation on macular thickness. METHODS: This was a retrospective, observational, cross-sectional study. Average foveal and central minimum thicknesses were measured by spectral-domain optical coherence tomography (SD-OCT) in 308 eyes of 308 healthy subjects (healthy group) and 298 normal fellow eyes of 298 patients with a unilateral macular hole (MH group). Multiple regression analyses were performed to determine the effects of various factors on the macular thickness...
October 7, 2016: Japanese Journal of Ophthalmology
Peter A Campochiaro, Andreas K Lauer, Elliott H Sohn, Tahreem A Mir, Stuart Naylor, Matthew C Anderton, Michelle Kelleher, Richard Harrop, Scott Ellis, Kyriacos A Mitrophanous
Neovascular age-related macular degeneration (NVAMD) is a prevalent cause of vision loss. Intraocular injections of VEGF-neutralizing proteins provide benefit, but many patients require frequent injections for a prolonged period. Benefits are often lost over time due to lapses in treatment. New treatments that sustain anti-angiogenic activity are needed. This study tested the safety and expression profile of a lentiviral Equine Infectious Anemia Virus (EIAV) vector expressing endostatin and angiostatin (RetinoStat(®))...
September 26, 2016: Human Gene Therapy
Aditya Kelkar, Jai Kelkar, Sampada Chitale, Rachana Shah, Ashish Jain, Shreekant Kelkar
BACKGROUND: The aim of this study was to assess the surgical outcomes of combined femtosecond laser-assisted cataract surgery (FLACS) with 25-gauge vitrectomy surgery. MATERIALS AND METHODS: A retrospective analysis of 45 patients who underwent combined FLACS with 25-gauge vitrectomy surgery. RESULTS: A total number of 45 eyes of 45 patients were treated with a mean age of 63.27 years (range 45-75). The mean follow-up was 3 months (range 3-12 months)...
August 2016: Indian Journal of Ophthalmology
Cheolmin Yun, Seong-Woo Kim, Kuhl Huh, Jaeryung Oh
No abstract text is available yet for this article.
2016: International Journal of Ophthalmology
Kazunori Tamaki, Ayumi Usui-Ouchi, Akira Murakami, Nobuyuki Ebihara
Purpose: The purpose of this study was to investigate whether fibrocytes participate in formation of the fibrovascular membrane (FVM) in patients with proliferative diabetic retinopathy (PDR). Methods: Vitreous fluid and FVM samples were obtained during vitrectomy in patients with PDR. Samples from patients with macular hole or epiretinal membrane were used as controls. Vitreous fluid and FVM samples were subjected to immunohistochemical analysis. In addition, cells isolated from the vitreous fluid of PDR and control patients were cultured in serum-free medium...
September 1, 2016: Investigative Ophthalmology & Visual Science
Jaesang Ko, Gyu Ah Kim, Sung Chul Lee, Jihwan Lee, Hyoung Jun Koh, Sung Soo Kim, Suk Ho Byeon, Christopher Seungkyu Lee
PURPOSE: To report the clinical findings and surgical outcomes of lamellar macular holes (LMHs) with and without lamellar hole-associated epiretinal proliferation (LHEP). METHODS: A retrospective review was performed of 73 eyes of 73 patients who underwent vitrectomy for LMH. Patients were grouped according to the presence of LHEP on preoperative spectral-domain optical coherence tomography (SD-OCT). Postoperative best-corrected visual acuity (BCVA) and OCT features were compared between LMH patients with and without LHEP...
September 20, 2016: Acta Ophthalmologica
Prethy Rao, Yoshihiro Yonekawa, Benjamin J Thomas, Kimberly A Drenser
PURPOSE: To compare the sensitivities of spectral-domain optical coherence tomography (SD-OCT) versus time-domain OCT (TD-OCT) in identifying epiretinal membranes (ERM) preoperatively in patients who underwent surgery for full-thickness macular holes (FTMH). METHODS: This is an interventional retrospective case series of 59 eyes diagnosed with FTMHs who underwent 25-G pars plana vitrectomy with internal limiting membrane peeling between 2009 and 2015. Preoperative OCTs were obtained by SD-OCT (Spectralis, Heidelberg, Germany) or TD-OCT (Stratus, Carl Zeiss Meditec, Dublin, CA, USA)...
September 17, 2016: European Journal of Ophthalmology
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