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Steven L Goldberg, Christoph Hammerstingl
Functional, or secondary, mitral regurgitation (FMR) is clinically important because patient with congestive heart failure with FMR have worse clinical outcomes and associated higher risks than patients without FMR. There is interest in finding repair techniques which may modify the mitral valve dysfunction and reduce the clinical impact. Although several devices have taken advantage of the close anatomical relationship between the coronary sinus and the posterior annulus of the mitral valve, in order to provide a cinching force on the mitral annulus, only the Carillon device is currently in use in humans...
January 2016: Interventional cardiology clinics
Julie Carillon, Bernard Jover, Jean-Paul Cristol, Jean-Max Rouanet, Sylvain Richard, Anne Virsolvy
BACKGROUND: Obesity-related metabolic syndrome is associated with high incidence of cardiovascular diseases partially consecutive to vascular dysfunction. Therapeutic strategies consisting of multidisciplinary interventions include nutritional approaches. Benefits of supplementation with a specific melon concentrate, enriched in superoxide dismutase (SOD), have previously been shown on the development of insulin resistance and inflammation in a nutritional hamster model of obesity. OBJECTIVE: We further investigated arterial function in this animal model of metabolic syndrome and studied the effect of melon concentrate supplementation on arterial contractile activity...
2016: Food & Nutrition Research
Piotr Kałmucki, Olga Jerzykowska, Rafał Dankowski, Artur Baszko, Lucyna Kramer, Andrzej Szyszka, Tomasz Siminiak
OBJECTIVES: The purpose of our study is to verify, whether percutaneous mitral annuloplasty results in reverse remodeling in patients with functional mitral regurgitation (FMR) and impaired ejection fraction (EF) and to investigate which echo parameters may help in prediction of the efficacy of the procedure. BACKGROUND: FMR exacerbates left ventricular (LV) dilatation and contributes to both LV remodeling and heart failure. METHODS: We analyzed baseline and 1 month follow-up data in 22 consecutive patients with FMR, who underwent successful percutaneous trans-coronary venous mitral annuloplasty with the Carillon device...
December 2016: Journal of Interventional Cardiology
Dennis Rottländer, Hubertus Degen, Michael Haude
No abstract text is available yet for this article.
September 18, 2016: EuroIntervention
Nagwa Abdelrahman, Mohammed Andaleeb Chowdhury, Arif Al Nooryani, Wael Elabbassi
Functional mitral regurgitation (FMR) is common in severe heart failure. Medical therapy is the standard of care since the role of surgery is less established. Various trans-catheter percutaneous techniques may avoid the risks of surgery; such as edge-to-edge repair using MitraClip system (Abbott Vascular, Illinois, USA) and CARILLON® Mitral Contour System® (Model XE2; Cardiac Dimensions., Kirkland, WA, USA). We present the case of a 41-year-old man with severe dilated cardiomyopathy, NYHA IIIb, and grade 3 MR...
December 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Janusz Lipiecki, Tomasz Siminiak, Horst Sievert, Jochen Müller-Ehmsen, Hubertus Degen, Justina C Wu, Christian Schandrin, Piotr Kalmucki, Ilona Hofmann, David Reuter, Steven L Goldberg, Michael Haude
OBJECTIVE: Functional (or secondary) mitral regurgitation (FMR) is associated with greater morbidity and worse outcomes in patients with congestive heart failure (CHF) and cardiomyopathy. The Carillon® Mitral Contour System® is a coronary sinus-based percutaneous therapy to reduce FMR. We evaluated the safety and efficacy of a modified version of the Carillon device in the treatment of patients with cardiomyopathy and FMR. METHODS: 36 patients with CHF, depressed left ventricular function (ejection fraction <40%) and at least moderate FMR underwent the Carillon device implant...
2016: Open Heart
J Carillon, F Barbé, S Barial, M Saby, A Sacy, J-M Rouanet
The objectives of this study were to investigate the effects of a specific melon concentrate on oviduct antioxidant defenses and egg characteristics of laying hens.Lohmann Brown hens were assigned to 2 treatment groups (n = 16 in each). One group was supplemented with the melon concentrate (26 mg/kg of feed) during 6 wk. The other group was composed of untreated hens, which served as control. Eggs were collected, weighed (yolk, albumen, shell), and analyzed (Haugh unit and albumen pH relevant for egg freshness) at the end of the supplementation period...
August 1, 2016: Poultry Science
Julie Carillon, Audrey Gauthier, Sandy Barial, Michel Tournier, Nathalie Gayrard, Anne-Dominique Lajoix, Bernard Jover
BACKGROUND: In spontaneously hypertensive rats (SHR), a model of human essential hypertension, oxidative stress is involved in the development of cardiac hypertrophy and fibrosis associated with hypertension. Dietary supplementation with agents exhibiting antioxidant properties could have a beneficial effect in remodeling of the heart. We previously demonstrated a potent anti-hypertrophic effect of a specific melon (Cucumis melo L.) concentrate with antioxidant properties in spontaneously hypertensive rats...
2016: Food & Nutrition Research
B Chabi, M Pauly, J Carillon, G Carnac, F B Favier, G Fouret, B Bonafos, F Vanterpool, B Vernus, C Coudray, C Feillet-Coudray, A Bonnieu, D Lacan, C Koechlin-Ramonatxo
While myostatin gene deletion is a promising therapy to fight muscle loss during aging, this approach induces also skeletal muscle metabolic changes such as mitochondrial deficits, redox alteration and increased fatigability. In the present study, we evaluated the effects of aging on these features in aged wild-type (WT) and mstn knockout (KO) mice. Moreover, to determine whether an enriched-antioxidant diet may be useful to prevent age-related disorders, we orally administered to the two genotypes a melon concentrate rich in superoxide dismutase for 12 weeks...
June 2016: Experimental Gerontology
Norbert Klein, Dietrich Pfeiffer, Steven Goldberg, Maika Klein
BACKGROUND AND AIMS: One option for interventional treatment of secondary mitral regurgitation is the placement of an indirect mitral annuloplasty device (Carillon Mitral Contour System) cinching the mitral annulus to facilitate coaptation of the mitral leaflets. The aim of this study is to evaluate the implantation success and hemodynamic results. METHODS AND RESULTS: Seventeen consecutive patients (11 females, 6 males) suffering from moderate to severe secondary mitral regurgitation (40% ischemic, 59% non-ischemic) received a Carillon Mitral Contour System device, which was evaluated prospectively in a single-center setting...
March 2016: Journal of Invasive Cardiology
Mathias Orban, D Braun, Martin Orban, L Gross, M Näbauer, C M Hagl, S Massberg, J Hausleiter
Severe mitral regurgitation (MR) is a growing medical challenge in today's aging population, leading to increased health expenditure due to the resultant morbidity and mortality. Surgery, either replacement or repair, has been the mainstay of therapy for primary MR. In high-risk or inoperable patients, treatment was limited to medical therapy until 2008. Since then, alternative percutaneous therapies have been introduced and have proven to be safe and effective in patients with secondary MR. Edge-to-edge repair with the MitraClip system is applied worldwide for primary and secondary MR...
February 2016: Herz
Charlotte J Haug
"We can meet after my lecture, at a table, over a drink," Carl Ogereau told me — that's "the French way to fight terrorism," he explained: refusing to be intimidated. So on Friday evening, one week after the Paris terrorist attack that left 130 dead and hundreds injured, Ogereau arrived on his..
December 31, 2015: New England Journal of Medicine
Steven L Goldberg, Janusz Lipiecki, Horst Sievert
No abstract text is available yet for this article.
September 2015: EuroIntervention
Oleg Borisenko, Michael Haude, Uta C Hoppe, Tomasz Siminiak, Janusz Lipiecki, Steve L Goldberg, Nawzer Mehta, Omari V Bouknight, Staffan Bjessmo, David G Reuter
BACKGROUND: To determine the cost-effectiveness of the percutaneous mitral valve repair (PMVR) using Carillon® Mitral Contour System® (Cardiac Dimensions Inc., Kirkland, WA, USA) in patients with congestive heart failure accompanied by moderate to severe functional mitral regurgitation (FMR) compared to the prolongation of optimal medical treatment (OMT). METHODS: Cost-utility analysis using a combination of a decision tree and Markov process was performed. The clinical effectiveness was determined based on the results of the Transcatheter Implantation of Carillon Mitral Annuloplasty Device (TITAN) trial...
2015: BMC Cardiovascular Disorders
Marie-Paule Lefranc, Véronique Giudicelli, Patrice Duroux, Joumana Jabado-Michaloud, Géraldine Folch, Safa Aouinti, Emilie Carillon, Hugo Duvergey, Amélie Houles, Typhaine Paysan-Lafosse, Saida Hadi-Saljoqi, Souphatta Sasorith, Gérard Lefranc, Sofia Kossida
IMGT(®), the international ImMunoGeneTics information system(®)( is the global reference in immunogenetics and immunoinformatics. By its creation in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), IMGT(®) marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT(®) is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH) and proteins of the IgSF and MhSF superfamilies...
January 2015: Nucleic Acids Research
Hani M Mahmoud, Mohammed A Al-Ghamdi, Abdullah E Ghabashi
The coronary sinus (CS) has become a clinically important structure especially through its role in providing access for different cardiac procedures such as arrhythmia ablation, biventricular pacing and recently, percutaneous valvular interventions. Fluoroscopy with or without two-dimensional transesophageal echocardiography is the widely used method for guidance. A 78-year-old female patient undergoing percutaneous CARILLON mitral annuloplasty device therapy for chronic severe symptomatic mitral regurgitation...
January 2015: Echocardiography
Julie Carillon, Claire Notin, Karine Schmitt, Guy Simoneau, Dominique Lacan
BACKGROUND: We aimed to investigate effects of superoxide dismutase (SOD)-melon concentrate supplementation on psychological stress, physical and mental fatigue in healthy people. METHODS: A randomized, double-blind, placebo-controlled trial was performed on 61 people divided in two groups: active supplement (n = 32) and placebo (n = 29) for 12 weeks. Volunteers were given one small hard capsule per day. One capsule contained 10 mg of SOD-melon concentrate (140 U of SOD) and starch for the active supplement and starch only for the placebo...
June 19, 2014: Nutrients
Julie Carillon, Caroline Rugale, Jean-Max Rouanet, Jean-Paul Cristol, Dominique Lacan, Bernard Jover
We assessed the influence of SODB, a melon superoxide dismutase (SOD), on left ventricular (LV) hypertrophy in SHR. SODB (4 or 40U SOD) was given orally for 4 or 28 days to SHR. For each treatment period, LV weight index (LVWI) and cardiomyocytes size were measured. SOD, glutathione peroxidase (GPx) and catalase expressions, and LV production and presence of superoxide anion were determined. Pro-inflammatory markers were also measured. SODB reduced LVWI and cardiomyocytes size after 4 or 28 days. Cardiac SOD and GPx increased by 30-40% with SODB...
August 2014: International Journal of Food Sciences and Nutrition
Tomasz Siminiak, Olga Jerzykowska, Michał Kuzemczak, Andrzej Szyszka, Piotr Kałmucki, Artur Baszko
BACKGROUND AND AIM: Functional mitral regurgitation (MR) remains a significant clinical problem. Surgical valve repair carries a high procedural risk. Thus, percutaneous techniques are under development. One of the most advanced devices for percutaneous mitral annuloplasty (PTMA) is the Carillon™ device. B-type natriuretic peptide (BNP) is a marker of haemodynamic status in heart failure patients. So far, its usefulness in patients after PTMA is unknown. METHODS: Thirteen consecutive patients after successful implantation of the Carillon™ device were enrolled...
2014: Kardiologia Polska
Tomasz Siminiak, Olga Jerzykowska, Piotr Kalmucki, Rafał Link, Artur Baszko
We present a case of a 45-year-old man with symptomatic heart failure and ischaemic functional mitral regurgitation (FMR), who underwent a successful percutaneous trans-coronary venous mitral annuloplasty with the Carillon system. The procedure resulted in clinical improvement as well as in a decrease in the degree of MR as assessed by echocardiography. Fifteen months later, the patient underwent cardiac resynchronisation (CRT) device implantation, resulting in a further improvement in echocardiographic measures of FMR...
2013: Kardiologia Polska
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