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https://www.readbyqxmd.com/read/28737334/-barriers-to-tuberculosis-awareness-and-screening-a-qualitative-study-in-a-french-department
#1
Séverine Carillon, Annabel Desgrées du Loû
The incidence of tuberculosis in Seine-Saint-Denis is considerably higher than the national average. The north-west part of the department is particularly concerned. Screening teams encounter difficulties communicating on the disease, reaching the populations concerned and obtaining their adhesion to the screening proposal. The objective of this study was to identify and elucidate the obstacles to tuberculosis prevention and screening. A qualitative study was conducted based on observation of screening actions in Seine-Saint-Denis and semi-directive interviews with health professionals in charge of screening, community representatives and associations, and individuals from the population concerned...
April 27, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28577672/a-randomized-double-blind-trial-of-an-interventional-device-treatment-of-functional-mitral-regurgitation-in-patients-with-symptomatic-congestive-heart-failure-trial-design-of-the-reduce-fmr-study
#2
RANDOMIZED CONTROLLED TRIAL
Steven L Goldberg, Ian Meredith, Thomas Marwick, Brian A Haluska, Janusz Lipiecki, Tomasz Siminiak, Nawzer Mehta, David M Kaye, Horst Sievert
The Carillon Mitral Contour System has been studied in 3 nonrandomized trials in patients with symptomatic congestive heart failure and functional mitral regurgitation. The REDUCE FMR study is a uniquely designed, double-blind trial evaluating the impact of the Carillon device on reducing regurgitant volume, as well as assessing the safety and clinical efficacy of this device. Carillon is a coronary sinus-based indirect annuloplasty device. Eligible patients undergo an invasive venogram to assess coronary sinus vein suitability for the Carillon device...
June 2017: American Heart Journal
https://www.readbyqxmd.com/read/28524699/comparison-of-ambulatory-blood-pressure-lowering-effects-of-higher-doses-of-different-calcium-antagonists-in-uncontrolled-hypertension-the-calcium-antagonist-controlled-release-high-dose-therapy-in-uncontrolled-refractory-hypertensive-patients-carillon-study
#3
Hiroyuki Mizuno, Satoshi Hoshide, Naoko Tomitani, Kazuomi Kario
BACKGROUND: Data are sparse regarding ambulatory blood pressure (BP) reduction of up-titration from a standard dose to a high dose in both nifedipine controlled-release (CR) and amlodipine. This was a prospective, randomized, multicenter, open-label trial. PATIENTS AND METHODS: Fifty-one uncontrolled hypertensives medicated by two or more antihypertensive drugs including a renin-angiotensin system inhibitor and a calcium antagonist were randomly assigned to either the nifedipine CR (80 mg)/candesartan (8 mg) group or the amlodipine (10 mg)/candesartan (8 mg) group...
May 19, 2017: Blood Pressure
https://www.readbyqxmd.com/read/28477282/implantation-of-carillon-%C3%A2-mitral-contour-system-with-transvenous-left-ventricular-lead-in-place
#4
T Wengenmayer, J Reinöhl, J Steinfurt, A Mittag, C Bode, J Biermann
BACKGROUND: Cardiac resynchronisation therapy (CRT) is an established treatment option for chronic heart failure patients with left bundle branch block. Although a concomitant functional mitral regurgitation is often reduced by CRT, many patients need additional mitral valve repair. Placing a CARILLON(®) Mitral Contour System (CMCS) over a transvenous CRT lead is currently not recommended, since both of them are implanted in the coronary sinus (CS). The aim of this study was to investigate the feasibility of sequential implantation of a transvenous LV lead followed by CMCS implantation, and to assess LV lead performance and possibility of extraction...
May 5, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28247436/treatment-of-functional-mitral-regurgitation-by-percutaneous-annuloplasty-using-the-carillon-mitral-contour-system-currently-available-data-state
#5
REVIEW
Dorothee H L Bail
OBJECTIVE: The purpose of this study is to provide a systematic review of currently available data about the percutaneous trans-coronary-venous mitral annuloplasty with the Carillon Mitral Contour System. METHOD: A systematic literature search was conducted using the common medical and scientific databases. The documented parameters included among others grade of mitral regurgitation (MR), vena contracta (VC), effective regurgitant orifice area (EROA), 6 minute-walk-test (6MWT), NYHA-classification, and Quality of Life (QoL) at baseline, 30 days and in the long-term follow-up...
April 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/27852485/coronary-sinus-based-approach-to-mitral-regurgitation
#6
REVIEW
Steven L Goldberg, Christoph Hammerstingl
Functional, or secondary, mitral regurgitation (FMR) is clinically important because patient with congestive heart failure with FMR have worse clinical outcomes and associated higher risks than patients without FMR. There is interest in finding repair techniques which may modify the mitral valve dysfunction and reduce the clinical impact. Although several devices have taken advantage of the close anatomical relationship between the coronary sinus and the posterior annulus of the mitral valve, in order to provide a cinching force on the mitral annulus, only the Carillon device is currently in use in humans...
January 2016: Interventional cardiology clinics
https://www.readbyqxmd.com/read/27834185/dietary-supplementation-with-a-specific-melon-concentrate-reverses-vascular-dysfunction-induced-by-cafeteria-diet
#7
Julie Carillon, Bernard Jover, Jean-Paul Cristol, Jean-Max Rouanet, Sylvain Richard, Anne Virsolvy
BACKGROUND: Obesity-related metabolic syndrome is associated with high incidence of cardiovascular diseases partially consecutive to vascular dysfunction. Therapeutic strategies consisting of multidisciplinary interventions include nutritional approaches. Benefits of supplementation with a specific melon concentrate, enriched in superoxide dismutase (SOD), have previously been shown on the development of insulin resistance and inflammation in a nutritional hamster model of obesity. OBJECTIVE: We further investigated arterial function in this animal model of metabolic syndrome and studied the effect of melon concentrate supplementation on arterial contractile activity...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27813186/percutaneous-trans-coronary-venous-mitral-annuloplasty-in-patients-with-functional-mitral-regurgitation-analysis-of-poznan-carillon-registry-data
#8
Piotr Kałmucki, Olga Jerzykowska, Rafał Dankowski, Artur Baszko, Lucyna Kramer, Andrzej Szyszka, Tomasz Siminiak
OBJECTIVES: The purpose of our study is to verify, whether percutaneous mitral annuloplasty results in reverse remodeling in patients with functional mitral regurgitation (FMR) and impaired ejection fraction (EF) and to investigate which echo parameters may help in prediction of the efficacy of the procedure. BACKGROUND: FMR exacerbates left ventricular (LV) dilatation and contributes to both LV remodeling and heart failure. METHODS: We analyzed baseline and 1 month follow-up data in 22 consecutive patients with FMR, who underwent successful percutaneous trans-coronary venous mitral annuloplasty with the Carillon device...
December 2016: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/27640037/the-carillon-strategies-for-optimal-patient-selection-and-optimised-results
#9
REVIEW
Dennis Rottländer, Hubertus Degen, Michael Haude
No abstract text is available yet for this article.
September 18, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27543418/a-case-of-dilated-cardiomyopathy-and-severe-mitral-regurgitation-treated-using-a-combined-percutaneous-approach-of-mitraclip-followed-by-carillon%C3%A2-mitral-contour-system
#10
Nagwa Abdelrahman, Mohammed Andaleeb Chowdhury, Arif Al Nooryani, Wael Elabbassi
Functional mitral regurgitation (FMR) is common in severe heart failure. Medical therapy is the standard of care since the role of surgery is less established. Various trans-catheter percutaneous techniques may avoid the risks of surgery; such as edge-to-edge repair using MitraClip system (Abbott Vascular, Illinois, USA) and CARILLON® Mitral Contour System® (Model XE2; Cardiac Dimensions., Kirkland, WA, USA). We present the case of a 41-year-old man with severe dilated cardiomyopathy, NYHA IIIb, and grade 3 MR...
December 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/27493761/coronary-sinus-based-percutaneous-annuloplasty-as-treatment-for-functional-mitral-regurgitation-the-titan-ii-trial
#11
Janusz Lipiecki, Tomasz Siminiak, Horst Sievert, Jochen Müller-Ehmsen, Hubertus Degen, Justina C Wu, Christian Schandrin, Piotr Kalmucki, Ilona Hofmann, David Reuter, Steven L Goldberg, Michael Haude
OBJECTIVE: Functional (or secondary) mitral regurgitation (FMR) is associated with greater morbidity and worse outcomes in patients with congestive heart failure (CHF) and cardiomyopathy. The Carillon® Mitral Contour System® is a coronary sinus-based percutaneous therapy to reduce FMR. We evaluated the safety and efficacy of a modified version of the Carillon device in the treatment of patients with cardiomyopathy and FMR. METHODS: 36 patients with CHF, depressed left ventricular function (ejection fraction <40%) and at least moderate FMR underwent the Carillon device implant...
2016: Open Heart
https://www.readbyqxmd.com/read/27143774/diet-supplementation-with-a-specific-melon-concentrate-improves-oviduct-antioxidant-defenses-and-egg-characteristics-in-laying-hens
#12
J Carillon, F Barbé, S Barial, M Saby, A Sacy, J-M Rouanet
The objectives of this study were to investigate the effects of a specific melon concentrate on oviduct antioxidant defenses and egg characteristics of laying hens.Lohmann Brown hens were assigned to 2 treatment groups (n = 16 in each). One group was supplemented with the melon concentrate (26 mg/kg of feed) during 6 wk. The other group was composed of untreated hens, which served as control. Eggs were collected, weighed (yolk, albumen, shell), and analyzed (Haugh unit and albumen pH relevant for egg freshness) at the end of the supplementation period...
August 1, 2016: Poultry Science
https://www.readbyqxmd.com/read/27079780/relaxin-and-atrial-natriuretic-peptide-pathways-participate-in-the-anti-fibrotic-effect-of-a-melon-concentrate-in-spontaneously-hypertensive-rats
#13
Julie Carillon, Audrey Gauthier, Sandy Barial, Michel Tournier, Nathalie Gayrard, Anne-Dominique Lajoix, Bernard Jover
BACKGROUND: In spontaneously hypertensive rats (SHR), a model of human essential hypertension, oxidative stress is involved in the development of cardiac hypertrophy and fibrosis associated with hypertension. Dietary supplementation with agents exhibiting antioxidant properties could have a beneficial effect in remodeling of the heart. We previously demonstrated a potent anti-hypertrophic effect of a specific melon (Cucumis melo L.) concentrate with antioxidant properties in spontaneously hypertensive rats...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/26944368/protective-effect-of-myostatin-gene-deletion-on-aging-related-muscle-metabolic-decline
#14
B Chabi, M Pauly, J Carillon, G Carnac, F B Favier, G Fouret, B Bonafos, F Vanterpool, B Vernus, C Coudray, C Feillet-Coudray, A Bonnieu, D Lacan, C Koechlin-Ramonatxo
While myostatin gene deletion is a promising therapy to fight muscle loss during aging, this approach induces also skeletal muscle metabolic changes such as mitochondrial deficits, redox alteration and increased fatigability. In the present study, we evaluated the effects of aging on these features in aged wild-type (WT) and mstn knockout (KO) mice. Moreover, to determine whether an enriched-antioxidant diet may be useful to prevent age-related disorders, we orally administered to the two genotypes a melon concentrate rich in superoxide dismutase for 12 weeks...
June 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/26773240/mitral-annuloplasty-device-implantation-for-non-surgical-treatment-of-mitral-regurgitation-clinical-experience-after-the-approval-studies
#15
Norbert Klein, Dietrich Pfeiffer, Steven Goldberg, Maika Klein
BACKGROUND AND AIMS: One option for interventional treatment of secondary mitral regurgitation is the placement of an indirect mitral annuloplasty device (Carillon Mitral Contour System) cinching the mitral annulus to facilitate coaptation of the mitral leaflets. The aim of this study is to evaluate the implantation success and hemodynamic results. METHODS AND RESULTS: Seventeen consecutive patients (11 females, 6 males) suffering from moderate to severe secondary mitral regurgitation (40% ischemic, 59% non-ischemic) received a Carillon Mitral Contour System device, which was evaluated prospectively in a single-center setting...
March 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/26659844/established-interventions-for-mitral-valve-regurgitation-current-evidence
#16
REVIEW
Mathias Orban, D Braun, Martin Orban, L Gross, M Näbauer, C M Hagl, S Massberg, J Hausleiter
Severe mitral regurgitation (MR) is a growing medical challenge in today's aging population, leading to increased health expenditure due to the resultant morbidity and mortality. Surgery, either replacement or repair, has been the mainstay of therapy for primary MR. In high-risk or inoperable patients, treatment was limited to medical therapy until 2008. Since then, alternative percutaneous therapies have been introduced and have proven to be safe and effective in patients with secondary MR. Edge-to-edge repair with the MitraClip system is applied worldwide for primary and secondary MR...
February 2016: Herz
https://www.readbyqxmd.com/read/26629999/report-from-paris
#17
Charlotte J Haug
"We can meet after my lecture, at a table, over a drink," Carl Ogereau told me — that's "the French way to fight terrorism," he explained: refusing to be intimidated. So on Friday evening, one week after the Paris terrorist attack that left 130 dead and hundreds injured, Ogereau arrived on his..
December 31, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26384195/the-carillon-mitral-contour-transcatheter-indirect-mitral-valve-annuloplasty-system
#18
Steven L Goldberg, Janusz Lipiecki, Horst Sievert
No abstract text is available yet for this article.
September 2015: EuroIntervention
https://www.readbyqxmd.com/read/25971307/cost-utility-analysis-of-percutaneous-mitral-valve-repair-in-inoperable-patients-with-functional-mitral-regurgitation-in-german-settings
#19
Oleg Borisenko, Michael Haude, Uta C Hoppe, Tomasz Siminiak, Janusz Lipiecki, Steve L Goldberg, Nawzer Mehta, Omari V Bouknight, Staffan Bjessmo, David G Reuter
BACKGROUND: To determine the cost-effectiveness of the percutaneous mitral valve repair (PMVR) using Carillon® Mitral Contour System® (Cardiac Dimensions Inc., Kirkland, WA, USA) in patients with congestive heart failure accompanied by moderate to severe functional mitral regurgitation (FMR) compared to the prolongation of optimal medical treatment (OMT). METHODS: Cost-utility analysis using a combination of a decision tree and Markov process was performed. The clinical effectiveness was determined based on the results of the Transcatheter Implantation of Carillon Mitral Annuloplasty Device (TITAN) trial...
2015: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/25378316/imgt%C3%A2-the-international-immunogenetics-information-system%C3%A2-25-years-on
#20
Marie-Paule Lefranc, Véronique Giudicelli, Patrice Duroux, Joumana Jabado-Michaloud, Géraldine Folch, Safa Aouinti, Emilie Carillon, Hugo Duvergey, Amélie Houles, Typhaine Paysan-Lafosse, Saida Hadi-Saljoqi, Souphatta Sasorith, Gérard Lefranc, Sofia Kossida
IMGT(®), the international ImMunoGeneTics information system(®)(http://www.imgt.org) is the global reference in immunogenetics and immunoinformatics. By its creation in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), IMGT(®) marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT(®) is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH) and proteins of the IgSF and MhSF superfamilies...
January 2015: Nucleic Acids Research
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