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Nepafenac

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https://www.readbyqxmd.com/read/28493461/ophthalmic-nepafenac-use-in-the-netherlands-and-denmark
#1
Andrea V Margulis, Eline Houben, Jesper Hallas, Jetty A Overbeek, Anton Pottegård, Tobias Torp-Pedersen, Susana Perez-Gutthann, Alejandro Arana
PURPOSE: To describe nepafenac use in the Netherlands and Denmark with reference to its approved indications. For context, we also describe the use of ketorolac and diclofenac. METHODS: We identified users in the PHARMO Database Network (the Netherlands, 2008-2013) and the Danish national health registers (Denmark, 1994-2014). We described prevalence of cataract surgery and duration of use in patients with cataract surgery with and without diabetes. RESULTS: In the Netherlands, 9530 nepafenac users (mean age, 71 years; 60% women) contributed 12 691 therapy episodes, of which 21% had a recently recorded cataract surgery...
May 10, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28407163/effect-of-topical-nonsteroidal-anti-inflammatory-drugs-on-pupillary-size-during-uncomplicated-cataract-surgery
#2
Alejandro Rodríguez-García, Julio C Hernández-Camarena, Gilberto R López-Jaime, José A Nava-García
PURPOSE: To compare the effectiveness of three different topical nonsteroidal anti-inflammatory drugs (NSAIDs) in inhibiting surgically induced miosis during uncomplicated cataract phacoemulsification. METHODS: Prospective, randomized, double-masked comparative study of patients aged 40 years or older with grades II to III cataracts (Lens Opacities Classification System) and no other comorbidities. Participants were randomized into four groups: 0.1% nepafenac, 0...
April 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28367202/effect-of-topical-nepafenac-in-prevention-of-macular-edema-after-cataract-surgery-in-patients-with-non-proliferative-diabetic-retinopathy
#3
Muhammad Haroon Sarfraz, Rana Intisar Ul Haq, Mohammad Asim Mehboob
OBJECTIVE: To determine the efficacy of topical Nepafenac (0.1%), administered post-operatively in prevention of Macular Edema (ME), after cataract surgery in patients with Non-Proliferative Diabetic Retinopathy (NPDR). METHODS: This randomized control trial was conducted at Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi from Sep 2015 to Sep 2016. Sixty eyes of 60 patients with NPDR underwent phacoemulsification with intraocular lens implantation. Group 1 received 0...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28320481/cystoid-macular-edema-associated-with-preservative-free-latanoprost-after-uncomplicated-cataract-surgery-case-report-and-review-of-the-literature
#4
REVIEW
Olga E Makri, Foteini N Tsapardoni, Panagiotis Plotas, Nikistratos Ifantis, Paraskevi T Xanthopoulou, Constantine D Georgakopoulos
BACKGROUND: Cystoid macular edema associated with latanoprost administration has been reported in patients after complicated cataract surgery with coexisting risk factors. We present the first case of preservative free latanoprost associated cystoid macular edema that occurred many months after uncomplicated cataract surgery. CASE PRESENTATION: A 65-year old Caucasian female presented in the Outpatients Clinic complaining of reduced vision and metamorphopsia in the right eye...
March 20, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28268098/nepafenac-0-3-after-cataract-surgery-in-patients-with-diabetic-retinopathy-results-of-2-randomized-phase-3-studies
#5
Rishi P Singh, Robert Lehmann, Joseph Martel, Kevin Jong, Ayala Pollack, Alexis Tsorbatzoglou, Giovanni Staurenghi, Guadalupe Cervantes-Coste Cervantes, Louis Alpern, Satish Modi, Liza Svoboda, Adeniyi Adewale, Glenn J Jaffe
PURPOSE: To demonstrate the efficacy and safety of once-daily nepafenac 0.3% ophthalmic suspension versus vehicle, based on clinical outcomes, after cataract surgery in patients with diabetes. DESIGN: Two prospective, randomized, multicenter, double-masked, vehicle-controlled phase 3 studies. PARTICIPANTS: Total, 615 patients in study 1 and 605 patients in study 2. METHODS: Patients were randomized (1:1) to topical nepafenac 0...
March 4, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28253334/comparison-of-the-efficacy-and-patients-tolerability-of-nepafenac-and-ketorolac-in-the-treatment-of-ocular-inflammation-following-cataract-surgery-a-meta-analysis-of-randomized-controlled-trials
#6
Xinyu Zhao, Song Xia, Erqian Wang, Youxin Chen
As a new ophthalmic non-steroidal anti-inflammatory drug (NSAID) with prodrug structure, Nepafenac was supposed to have a better efficacy than conventional NSAIDs both in patients' tolerability and ocular inflammation associated with cataract surgery. However, many current studies reached contradictory conclusions on the superiority of Nepafenac over Ketorolac. The objective of our study is to evaluate the efficacy and patients' tolerability of Nepafenac and Ketorolac following cataract surgery. To clarify this, we conducted a meta-analysis of randomized controlled trials...
2017: PloS One
https://www.readbyqxmd.com/read/28219426/pseudophakic-cystoid-macular-edema-prevention-and-risk-factors-prospective-study-with-adjunctive-once-daily-topical-nepafenac-0-3-versus-placebo
#7
RANDOMIZED CONTROLLED TRIAL
Sean McCafferty, April Harris, Corin Kew, Tala Kassm, Lisa Lane, Jason Levine, Meisha Raven
BACKGROUND: Define the effectiveness of a topical non-steroidal anti-inflammatory drug (NSAID) added to topical steroid use after uncomplicated phacoemulsification for the prevention of pseudophakic cystoid macular edema (PCME) using a prospective, randomized, double-masked, placebo-controlled clinical study. METHODS: Eyes (1000) were randomized to placebo (497) or nepafenac 0.3% (503) used once daily, post-operatively for 5 weeks at two ophthalmology clinics. Diagnosis of PCME was made by clinical, ocular coherence tomography (OCT), and with fluorescein angiography confirmation...
February 20, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28130595/the-comparative-efficacy-and-safety-of-topical-non-steroidal-anti-inflammatory-drugs-for-the-treatment-of-anterior-chamber-inflammation-after-cataract-surgery-a-systematic-review-and-network-meta-analysis
#8
REVIEW
Ping Duan, Yong Liu, Jiawen Li
PURPOSE: Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of anti-inflammatory drugs that are used in ophthalmologic surgery. These drugs do not have a steroid structure, but can inhibit surgery-induced miosis, anterior chamber inflammation, and cystoid macular edema (CME). However, the application of NSAIDs remains controversial. Therefore, we performed a meta-analysis to assess the efficacy and safety of NSAIDs for the treatment of anterior chamber inflammation after cataract surgery...
January 27, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28080174/the-use-of-topical-non-steroidal-anti-inflammatory-drugs-for-uveitic-cystoid-macular-edema
#9
Harry Petrushkin, Duncan Rogers, Carlos Pavesio
The use of topical non-steroidal anti-inflammatory drugs in the management of uveitic cystoid macular edema is controversial. In this letter, we review the literature and report our results from a retrospective case series of 281 patients taking topical nepafenac 0.1% for uveitic cystoid macular edema between 2010 and 2016. Over a 4-month period, there was a modest improvement in best-corrected visual acuity (0.66 ± 3.7 logMAR) and central macular thickness (69.8 ± 132.5 μm). Patients with idiopathic anterior uveitis and HLA-B*27-associated anterior uveitis recovered more vision while taking topical nepafenac 0...
January 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27971626/cost-effectiveness-of-nepafenac-3-mg-ml-for-the-reduction-in-risk-of-post-operative-macular-oedema-associated-with-cataract-surgery-from-uk-nhs-perspective
#10
A Mullins, P Meijer, R Airey, P Gunda, J Banhazi
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27911428/-macular-edema-after-prior-brachytherapy-in-a-diabetic-retinopathy-patient-clinical-case
#11
S A Ignat'ev, O N Steshenko, Ya N Khionidi
The authors describe a case of radiation retinopathy after brachytherapy for uveal melanoma successfully treated with nepafenac 0.1%, a non-steroidal anti-inflammotory agent.
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27843229/a-comparative-study-of-various-topical-nonsteroidal-anti-inflammatory-drugs-to-steroid-drops-for-control-of-post-cataract-surgery-inflammation
#12
Anu Malik, Anup Sadafale, Yogesh Kumar Gupta, Alka Gupta
BACKGROUND: Postoperative inflammation continues to be a cause of patient discomfort, delayed recovery, and in some cases, suboptimal visual results. Topical nonsteroidal anti-inflammatory drugs (NSAIDs) and steroid are commonly used in the management and prevention of noninfectious ocular inflammation following cataract surgery. AIMS: The aim was to study the safety and efficacy of various NSAIDs drops for control of postoperative inflammation following cataract surgery and compare with steroid eye drops in a patient following cataract surgery...
September 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27801522/prophylactic-non-steroidal-anti-inflammatory-drugs-for-the-prevention-of-macular-oedema-after-cataract-surgery
#13
REVIEW
Blanche X Lim, Chris Hl Lim, Dawn K Lim, Jennifer R Evans, Catey Bunce, Richard Wormald
BACKGROUND: Macular oedema (MO) is the accumulation of extracellular fluid in the central retina (the macula). It may occur after cataract surgery and may give rise to poor visual outcome, with reduced visual acuity and distortion of the central vision. MO is often self-limiting with spontaneous resolution, but a small proportion of people with chronic persistent MO may be difficult to treat. Chronic oedema may lead to the formation of cystic spaces in the retina termed 'cystoid macular oedema' (CMO)...
November 1, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27771823/effect-of-nepafenac-on-the-foveal-profile-of-glaucomatous-patients-undergoing-phacoemulsification
#14
Elena Milla, Oana Stirbu, Isabel Jimenez Franco, Santiago J García Hernández, Jose Rios, Susana Duch
PURPOSE: Retrospective, pilot study to determine whether nepafenac treatment pre- and postcataract surgery in glaucoma patients using topical hypotensive agents minimized cystoid macular edema by comparing pre- and postsurgical foveal characteristics, as in some cases these agents cannot be withdrawn and, hypothetically, their inflammatory effect on the fovea could be neutralized by the addition of nepafenac. METHODS: Patients were divided into two subgroups depending on whether or not topical nepafenac was added to the surgical protocol (NEP = nepafenac group and nNEP = non nepafenac group)...
October 22, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27766540/topical-nonsteroidal-anti-inflammatory-drugs-as-adjuvant-therapy-in-the-prevention-of-macular-edema-after-cataract-surgery
#15
Nicola Cardascia, Carmela Palmisano, Tersa Centoducati, Giovanni Alessio
PURPOSE: The purpose of the study was to assess adjuvant treatment with topical nonsteroidal anti-inflammatory drugs (NSAIDs) (0.9 % bromfenac, 0.1 % nepafenac, 0.5 % indomethacin, or 0.1 % diclofenac) in addition to topical steroidal treatment with 0.1 % dexamethasone and 0.3 % netilmicin for prevention of cystoid macular edema (CME) after uneventful small incision cataract extraction with foldable intraocular lens (IOL) implantation. SETTING: Institute of Ophthalmology, Department of Scienze Mediche di Base, Neuroscienze ed Organi di Senso, Aldo Moro University, Policlinico Consorziale di Bari, Bari, Italy...
October 20, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27702506/a-novel-ph-induced-thermosensitive-hydrogel-composed-of-carboxymethyl-chitosan-and-poloxamer-cross-linked-by-glutaraldehyde-for-ophthalmic-drug-delivery
#16
Shihui Yu, Xiaoyu Zhang, Guoxin Tan, Lei Tian, Dandan Liu, Yaxuan Liu, Xinggang Yang, Weisan Pan
In this work, a stimuli-responsive three dimensional cross-linked hydrogel system containing carboxymethyl chitosan (CMC) and poloxamer composed of a poly (ethylene oxide)/poly (propylene oxide)/poly (ethylene oxide) (PEO-PPO-PEO) block copolymer was constructed, and its aqueous solution was found to undergo a reversible sol-gel transition upon a temperature and/or pH change at a very low concentration. The hydrogels were synthesized via a cross-linking reaction using glutaraldehyde (GA) as the cross-linking agent...
January 2, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27585567/cystoid-macular-edema-associated-with-iridocorneal-endothelial-syndrome-a-case-report
#17
Keita Suzuki, Tadashi Mizuguchi, Yui Seno, Atsuhiro Tanikawa, Masayuki Horiguchi
BACKGROUND: Iridocorneal endothelial (ICE) syndrome occurs mainly in young and middle-aged women and typically presents as a unilateral disease characterized by abnormalities of the iris and corneal endothelium. While the ICE syndrome is known to be associated with glaucoma and bullous keratopathy, to our knowledge, only two cases of ICE syndrome complicated with cystoid macular edema (CME) have been reported to date. In this paper, we report a case of ICE syndrome complicated with CME treated at our institution...
September 1, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27559517/eyelid-excoriation-and-erythema-with-nepafenac-eye-drop
#18
Kumar Saurabh, Rupak Roy, Debmalya Das, Aneesha Lobo
No abstract text is available yet for this article.
July 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27539765/frequency-of-systemic-risk-factors-in-central-serous-chorioretinopathy
#19
Qamar Ul Islam, Muhammad Kashif Hanif, Sheraz Tareen
OBJECTIVE: To determine the frequency of various systemic risk factors associated with acute central serous chorioretinopathy (CSCR) in our setup. STUDY DESIGN: Descriptive case series. PLACE AND DURATION OF STUDY: Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi, from July 2011 to June 2014. METHODOLOGY: All consecutive patients with acute CSCR who presented in the outpatient department during the study period were recruited...
August 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27513223/comparison-of-the-tolerability-of-diclofenac-and-nepafenac
#20
Asaf Achiron, Lily Karmona, Michael Mimouni, Assaf Gershoni, Yana Dzhanov, Zvi Gur, Zvia Burgansky
PURPOSE: Topical nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the prevention and treatment of inflammation and pain following cataract surgery. Preservative-free diclofenac and nepafenac drops are commonly used ophthalmic NSAIDs. The purpose of this study was to compare the tolerability of diclofenac to that of nepafenac. METHODS: In this prospective patient-blinded study, consecutive patients undergoing cataract surgery were included. One drop of nepafenac 0...
August 11, 2016: Journal of Ocular Pharmacology and Therapeutics
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