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Internal limiting membrane

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https://www.readbyqxmd.com/read/28334923/validated-rp-hplc-dad-method-for-the-quantification-of-insect-repellent-ethyl-2-aminobenzoate-in-membrane-moderated-matrix-type-monolithic-polymeric-device
#1
Johirul Islam, Kamaruz Zaman, Srijita Chakrabarti, Nilutpal Sharma Bora, Santa Mandal, Manash Pratim Pathak, Pakalapati Srinivas Raju, Pronobesh Chattopadhyay
A simple, accurate and sensitive reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the estimation of ethyl 2-aminobenzoate (EAB) in a matrix type monolithic polymeric device and validated as per the International Conference on Harmonization guidelines. The analysis was performed isocratically on a ZORBAX Eclipse plus C18 analytical column (250 × 4.4 mm, 5 μm) and a diode array detector (DAD) using acetonitrile and water (75:25 v/v) as the mobile phase by keeping the flow-rate constant at 1...
March 14, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28333857/successful-closure-of-full-thickness-macular-holes-secondary-to-macular-vitelliform-lesions
#2
Justin C Galvin, Brian E Chua, Adrian T Fung
PURPOSE: To describe the first reported cases of full-thickness macular holes secondary to vitelliform lesions that were successfully closed with vitrectomy surgery and gas tamponade. METHODS: Two female patients developed visual loss secondary to bilateral vitelliform lesions and associated full-thickness macular holes. The patients underwent 25-gauge pars plana vitrectomy, internal limiting membrane peeling, and 26% sulfur hexafluoride gas, followed by 3 days of face-down positioning...
March 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28333852/re-intervention-in-de-novo-vitreous-opacities-after-pars-plana-vitrectomy-in-familial-amyloidotic-polyneuropathy-ttr-val30metportuguese-patients
#3
Natália Novais Ferreira, David Afonso Cunha Dias, Rui Pedro Afonso Carvalho, Maria Teresa Pardal Monteiro Coelho
PURPOSE: To report management of de novo vitreous amyloid opacities after previous pars plana vitrectomy in familial amyloidotic polyneuropathy transthyretin Val30Met. METHODS: This work is a retrospective observational consecutive case series of five eyes of four patients. Demographic data, transthyretin mutation involved, age at the beginning of disease, duration of disease, treatment (liver transplant or tafamidis), time between vitrectomy and re-intervention, and ophthalmologic changes were evaluated...
March 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28333716/internal-aspiration-under-perfluorocarbon-liquid-for-the-management-of-large-macular-holes
#4
Oded Ohana, Adiel Barak, Shulamit Schwartz
PURPOSE: To report the outcomes of pars plana vitrectomy with internal aspiration under perfluorocarbon liquid for large macular holes (MH). METHODS: Retrospective consecutive case series of patients with large (>400 µm) MH. All treated were with pars plana vitrectomy, internal limiting membrane peeling, internal fluid aspiration under perfluorocarbon liquid, and gas/oil tamponade. Outcomes included closure rate and visual acuity at 6 months. RESULTS: Twenty eyes of 20 patients were included...
January 11, 2017: Retina
https://www.readbyqxmd.com/read/28331946/-technique-of-proton-and-phosphorous-mr-spectroscopy
#5
M Backens
CLINICAL/METHODICAL ISSUE: Magnetic resonance spectroscopy (MRS) is an important non-invasive method that can reveal the concentration and spatial distribution of particular biochemically relevant tissue metabolites. STANDARD RADIOLOGICAL METHODS: Proton MRS is routinely applicable in the clinical setting providing good quality results even with a moderate magnetic field strength of 1.5 T. Relative values of metabolite concentrations are mostly used for the assessment of metabolic disorders...
March 22, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28331373/decrease-of-the-foveal-avascular-zone-area-after-internal-limiting-membrane-peeling-single-case-study
#6
Kazuyuki Kumagai, Akinori Uemura, Mariko Furukawa, Tetsuyuki Suetsugu, Nobuchika Ogino
PURPOSE: To report a patient whose foveal avascular zone (FAZ) decreased after vitrectomy with internal limiting membrane (ILM) peeling. METHODS: A 58-year-old woman underwent successful phacovitrectomy with ILM peeling for a thin epiretinal membrane in an eye with a normal foveal contour. Optical coherence tomography angiographic en face images of the 3 mm×3 mm superficial and deep inner retinal vascular plexuses were examined preoperatively, and on days 1, 2, 9, and 37 postoperatively...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28330734/enhanced-cellular-uptake-and-gene-silencing-activity-of-sirna-using-temperature-responsive-polymer-modified-liposome
#7
Jian Wang, Eri Ayano, Yoshie Maitani, Hideko Kanazawa
Short interfering RNA (siRNA) delivery systems using nanoparticle carriers have been limited by inefficient intracellular delivery. One drawback is the poor cellular uptake of siRNA/particle complexes through the plasma membrane and release of the nucleic acids into the cytosol. In this study, to develop the temperature-responsive liposome as a novel carrier for siRNA delivery, we prepared lipoplexes and assessed cellular uptake of siRNA and gene silencing activity of target genes, compared with those of a commercial transfection reagent, Lipofectamine RNAiMAX, and non-modified or PEGylated liposomes...
March 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28318697/how-do-low-doses-of-desferrioxamine-b-and-edta-affect-the-phytoextraction-of-metals-in-sunflower
#8
J Y Cornu, C Dépernet, C Garnier, V Lenoble, A Braud, T Lebeau
The aim of this study was to compare the efficiency of siderophore desferrioxamine B (DFOB) and EDTA in increasing the phytoextraction of metals in sunflower. A 28-day pot experiment was conducted in a metal-contaminated soil supplied with 200μmolkg(-1) of DFOB or EDTA. Pore water was collected and pseudo-polarographic analyses were conducted to assess the impact of the two chelators on the mobility and speciation of metals in the liquid phase. Our results showed that DFOB is not an efficient mobilizing agent of divalent metals in soil...
March 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28316197/-inhibitory-effect-of-insulin-like-growth-factor-binding-protein-related-protein-1-on-retinal-angiogenesis-via-erk-signaling-pathway
#9
P Zhang, H Wang, H Cao, X Xu, T Sun
Objective: To explore the inhibitory effect of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1), a novel anti-angiogenic factor, on retinal angiogenesis and its underlying molecular mechanisms. Methods: Experimental study. C57BL/6J mice were classified into three groups: control group (n=24), oxygen-induced retinopathy (OIR) non-intervention group (n=24) and OIR intervention group (n=72). The OIR mouse model was established using improved Smith's methods (n= 96). Twelve-day-old mice in the OIR intervention group were randomly assigned into three groups receiving intravitreal injection of recombinant mouse IGFBP-rP1 (50 μg/L, 100 μg/L and 200 μg/L, respectively)...
March 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28314834/internal-limiting-membrane-peeling-or-not-a-systematic-review-and-meta-analysis-of-idiopathic-macular-pucker-surgery
#10
Xiao-Ling Fang, Yao Tong, Ya-Li Zhou, Pei-Quan Zhao, Zhao-Yang Wang
PURPOSE: To determine whether internal limiting membrane (ILM) peeling improves anatomical and functional outcomes in idiopathic macular pucker (IMP)/epiretinal membrane (ERM) surgery in this systematic review and meta-analysis. METHODS: We searched the PubMed, Medline, Web of Science, Cochrane, Ovid MEDLINE, ClinicalTrials.gov and CNKI databases for studies published before 15 September 2016. The eligibility criteria included studies comparing ILM peeling versus no-peeling for IMP surgery...
March 17, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28299798/sterol-glycosyltransferases-required-for-adaptation-of-withania-somnifera-at-high-temperature
#11
Gaurav Singh, Manish Tiwari, Surendra Pratap Singh, Ruchi Singh, Surendra Singh, Pramod Arvind Shirke, Prabodh K Trivedi, Pratibha Misra
Heat is a major environmental stress factor that confines growth, productivity, and metabolism of plants. Plants respond to such unfavorable conditions through changes in their physiological, biochemical and developmental processes. Withania somnifera, an important medicinal plant, grows in hot and dry conditions, however, molecular mechanisms related to such adaptive properties are not known. Here, we elucidated that members of the SGT gene family play important roles in the survival of W. somnifera under adverse conditions through maintaining the integrity of the membrane...
March 16, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28299505/changes-in-membrane-lipids-drive-increased-endocytosis-following-fas-ligation
#12
Mauro Degli Esposti, Paola Matarrese, Antonella Tinari, Agostina Longo, Serena Recalchi, Roya Khosravi-Far, Walter Malorni, Roberta Misasi, Tina Garofalo, Maurizio Sorice
Once activated, some surface receptors promote membrane movements that open new portals of endocytosis, in part to facilitate the internalization of their activated complexes. The prototypic death receptor Fas (CD95/Apo1) promotes a wave of enhanced endocytosis that induces a transient intermixing of endosomes with mitochondria in cells that require mitochondria to amplify death signaling. This initiates a global alteration in membrane traffic that originates from changes in key membrane lipids occurring in the endoplasmic reticulum (ER)...
March 15, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28297658/multiscale-modeling-of-complex-formation-and-cd80-depletion-during-immune-synapse-development
#13
István P Sugár, Jayajit Das, Ciriyam Jayaprakash, Stuart C Sealfon
The mechanisms that discriminate self- and foreign antigen before T cell activation are unresolved. As part of the immune system's adaptive response to specific infections or neoplasms, antigen-presenting cells (APC) and effector T cells form transcellular molecular complexes. CTLA4 expression on regulatory or effector T cells reduces T cell activation. The CTLA4 transendocytosis hypothesis proposes that CTLA4 depletes CD80 and CD86 proteins from the APC membrane, rendering the APC incapable of activating T cells...
March 14, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28292775/effectiveness-of-combined-macular-buckle-under-direct-vision-and-vitrectomy-with-ilm-peeling-in-refractory-macular-hole-retinal-detachment-with-extreme-high-axial-myopia-a-24-month-comparative-study
#14
Jin Ma, Honghui Li, Xiaohu Ding, Silvia Tanumiharjo, Lin Lu
PURPOSE: To evaluate the efficacy of a combined macular buckle under direct vision and 23-gauge pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling in refractory macular hole retinal detachment (MHRD) with extreme high axial myopia. DESIGN: Prospective, randomised controlled study. PARTICIPANTS: The study included 98 eyes of 98 patients of MHRD with extreme high axial (>30 mm) myopia. INTERVENTION: Patients were randomly assigned to undergo PPV with ILM peeling (group 1, n=52) or PPV with ILM peeling combined with macular buckle under direct vision (group 2, n=46)...
March 14, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28282068/surgical-treatment-and-optical-coherence-tomographic-evaluation-for-accidental-laser-induced-full-thickness-macular-holes
#15
Y Qi, Y Wang, Q You, F Tsai, W Liu
PurposeTo report OCT appearance and surgical outcomes of full-thickness macular holes (MHs) accidentally caused by laser devices.Patients and methodsThis retrospective case series included 11 eyes of 11 patients with laser-induced MHs treated by pars plana vitrectomy, internal limiting membrane (ILM) peeling, and gas or silicone oil tamponade. Evaluations included a full ophthalmic examination, macular spectral-domain optical coherence tomography (SD-OCT), and fundus photography. Main outcome measures is MH closure and final visual acuity; the secondary outcome was the changes of retinal pigment epithelium and photoreceptor layer evaluated by sequential post-operative SD-OCT images...
March 10, 2017: Eye
https://www.readbyqxmd.com/read/28277441/changes-in-the-posterior-vitreous-after-cataract-surgery-assessed-by-swept-source-optical-coherence-tomography
#16
Yuki Otsuka, Sotaro Ooto, Nagahisa Yoshimura
PURPOSE: To assess changes in the posterior vitreous caused directly by phacoemulsification with implantation of an intraocular lens, using the enhanced vitreous swept-source optical coherence tomography system (Topcon, Tokyo, Japan). METHODS: Consecutive patients with cataract without posterior vitreous detachment were enrolled. Swept-source optical coherence tomography examinations were performed 1 day before and several days after surgery, using enhanced vitreous visualization...
March 8, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28274796/dual-functional-lipomet-mediates-envelope-type-nanoparticles-to-combinational-oncogene-silencing-and-tumor-growth-inhibition
#17
Kai Shi, Yi Zhao, Lei Miao, Andrew Satterlee, Matthew Haynes, Cong Luo, Sara Musetti, Leaf Huang
The success of small interfering RNA (siRNA)-mediated gene silencing for cancer therapy is still limited because of its instability and poor intracellular internalization. Traditional cationic carriers cannot adequately meet the need for clinical application of siRNA. We herein report a dual-functional liposome containing a cholesterol derivative of metformin, i.e., LipoMET, which takes advantage of the fusogenic activity as well as intrinsic tumor apoptosis inducing ability of biguanide moiety to achieve a combinational anti-oncogenic effect...
March 5, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28268725/low-power-operation-of-a-barometric-pressure-sensor-for-use-in-an-automatic-fall-detector
#18
Wei Lu, Changhong Wang, Michael C Stevens, Stephen J Redmond, Nigel H Lovell
The use of a barometric pressure sensor in a wearable fall detector has been shown to improve the detection accuracy by determining the altitude change associated with the fall event. However, the barometer is a high-power-consuming sensor. This paper proposes a fall detection approach using a hermetically sealed and waterproof enclosure incorporating a small window covered by a semi-permeable membrane (SPM) to delay the equilibrium of internal and external pressures. This feature can be utilized to limit the time the barometer is powered but still capturing critical pressure information to discriminate fall and non-fall events...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28260064/tumor-penetrating-peptide-fused-to-a-pro-apoptotic-peptide-facilitates-effective-gastric-cancer-therapy
#19
Ying Huang, Xihan Li, Huizi Sha, Lianru Zhang, Xinyu Bian, Xiao Han, Baorui Liu
KLA (sequence, KLAKLAKKLAKLAK) is a peptide which leads to programmed cell death by disrupting the mitochondrial membrane. However, low penetration in tumors greatly limits its application and efficacy. To develop a KLA-based cancer therapy, KLA-iRGD, a recombinant protein was constructed. It consists of the KLA peptide and iRGD (CRGDKGPDC), a tumor-homing peptide with high penetration into tumor tissue and cells. The conjugated KLA exhibits pro-apoptotic activity to prevent the growth of a tumor once it is inside the cell...
February 10, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28257377/vitrectomy-for-intermediate-age-related-macular-degeneration-associated-with-tangential-vitreomacular-traction-a-clinicopathologic-correlation
#20
Jean Ziada, Felix Hagenau, Denise Compera, Armin Wolf, Renate Scheler, Markus M Schaumberger, Siegfried G Priglinger, Ricarda G Schumann
PURPOSE: To describe the morphologic characteristics of the vitreomacular interface in intermediate age-related macular degeneration associated with tangential traction due to premacular membrane formation and to correlate with optical coherence tomography (OCT) findings and clinical data. METHODS: Premacular membrane specimens were removed sequentially with the internal limiting membrane from 27 eyes of 26 patients with intermediate age-related macular degeneration during standard vitrectomy...
March 1, 2017: Retina
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