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Internal limiting membrane

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https://www.readbyqxmd.com/read/28438780/penetration-route-of-the-selective-glucocorticoid-receptor-agonist-sa22465-and-betamethasone-into-rabbit-meibomian-gland-based-on-pharmacokinetics-and-autoradiography
#1
Nagayoshi Asano, Kenji Ueda, Kouichi Kawazu
Meibomian glands are tiny sebaceous glands embedded within specific types of dense connective tissues. This study investigated drug penetration into meibomian glands following a single topical administration in rabbits. We measured time-course concentrations of the selective glucocorticoid receptor agonist (SEGRA) SA22465 and betamethasone in lid margins, palpebral conjunctival epithelium, and meibomian glands following a single instillation using a newly established collection method. We also visualized the distribution of (14)C-SA22465 in eyelid tissue sections using micro-autoradiography...
April 24, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28437318/results-of-macular-hole-surgery-evaluation-based-on-the-international-vitreomacular-traction-study-classification
#2
Laura Liu, Ijilmurun Enkh-Amgalan, Nan-Kai Wang, Lan-Hsin Chuang, Yen-Po Chen, Yih-Shiou Hwang, Chee-Jen Chang, Kuan-Jen Chen, Wei-Chi Wu, Tun-Lu Chen, Chi-Chun Lai
PURPOSE: To evaluate the differences in anatomical and visual function changes after macular hole (MH) surgery using the International Vitreomacular Traction Study classification. METHODS: Patients who underwent vitrectomy and blood-assisted internal limiting membrane peeling because of MHs were enrolled in the present study. The patients were divided into three groups according to the sizes of their MHs (small: ≤250 μm, medium: >250 μm and ≤400 μm, and large: >400 μm)...
April 20, 2017: Retina
https://www.readbyqxmd.com/read/28435209/increase-in-average-foveal-thickness-after-internal-limiting-membrane-peeling
#3
Kazuyuki Kumagai, Mariko Furukawa, Tetsuyuki Suetsugu, Nobuchika Ogino
PURPOSE: To report the findings in three cases in which the average foveal thickness was increased after a thin epiretinal membrane (ERM) was removed by vitrectomy with internal limiting membrane (ILM) peeling. METHODS: The foveal contour was normal preoperatively in all eyes. All cases underwent successful phacovitrectomy with ILM peeling for a thin ERM. The optical coherence tomography (OCT) images were examined before and after the surgery. The changes in the average foveal (1 mm) thickness and the foveal areas within 500 μm from the foveal center were measured...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28432184/management-of-a-case-of-myopic-foveoschisis-with-phakic-intraocular-lens-piol-in-situ-intraoperative-challenges
#4
Atul Kumar, Aditi Mehta, Raghav Dinesh Ravani, Prateek Kakkar
We describe the case of a 30-year-old man with pathological myopia with a phakic intraocular lens (IOL) (Visian ICL V4c model; STAAR, Monrovia, California, USA) in situ having complaints of metamorphopsia in the left eye with documented myopic foveoschisis on swept-source optical coherence tomography (DRI OCT Triton; Topcon, Tokyo, Japan). The patient underwent pars plana vitrectomy with internal limiting membrane peeling. This report discusses the intraoperative challenges occurring as a result of increased optical aberrations in the presence of a phakic IOL...
April 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28430333/epiretinal-membrane-negative-staining-and-double-peeling-in-a-single-block-with-brilliant-blue-g
#5
David Martins, Pedro Neves
PURPOSE: To describe a surgical technique for combined peeling of epiretinal and internal limiting membranes. METHODS: The authors present their procedure of choice for epiretinal membrane surgery: negative staining effect using Brilliant Blue G and single block removal of the epiretinal and internal limiting membranes in a single step. RESULTS: A total of 26 eyes were operated with the described technique. In all cases, the peeling was performed successfully and with no complications...
April 18, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28430324/negative-staining-of-the-vitreous-with-the-use-of-vital-dyes
#6
Cesare Mariotti, Michele Nicolai, Simone Donati, Michele Reibaldi
PURPOSE: The vitreous cortex, epiretinal membrane (ERM), and inner limiting membrane (ILM) are transparent tissues and are thus difficult to visualize. Staining these structures can increase the efficiency of a nontraumatic removal. METHODS: The surgeon performs a partial core vitrectomy and induces a posterior vitreous detachment. The vital dye is then injected into the retrohyaloid space in balanced salt solution (BSS). The dyes used are TWIN (Alchimia srl, Padova, Italy), MembraneBlue-Dual (DORC International, Zuidland, the Netherlands), and Doubledyne (Alfa Intes, Casoria, Italy)...
April 13, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28426241/extracellular-heme-uptake-and-the-challenge-of-bacterial-cell-membranes
#7
Weiliang Huang, Angela Wilks
Iron is essential for the survival of most bacteria but presents a significant challenge given its limited bioavailability. Furthermore, the toxicity of iron combined with the need to maintain physiological iron levels within a narrow concentration range requires sophisticated systems to sense, regulate, and transport iron. Most bacteria have evolved mechanisms to chelate and transport ferric iron (Fe(3+)) via siderophore receptor systems, and pathogenic bacteria have further lowered this barrier by employing mechanisms to utilize the host's hemoproteins...
April 19, 2017: Annual Review of Biochemistry
https://www.readbyqxmd.com/read/28424563/traumatic-reopening-of-macular-hole-following-successful-surgical-repair
#8
Margaret Wong, Robert L Halpern, James H Frank
A 75-year-old Caucasian female with a full-thickness macular hole underwent a successful surgical repair. Vision improved from 20/400 to 20/30 after surgery. Two years later, the patient presented with a decreased vision after a fall onto her face with a reopened full-thickness macular hole. Vision decreased to 20/400 and then she underwent a second surgery with an internal limiting membrane peeling, which resulted in a second successful closure of her macular hole. Vision following the second surgery was 20/100...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28419402/autologous-free-internal-limiting-membrane-flap-for-optic-nerve-head-pit-with-maculopathy
#9
Palmeera D'Souza, Upendra Babu, Venkatapathy Narendran
Optic disc pits (ODPs) are associated with serous macular detachment (SMD), which causes visual loss in 25% to 75% patients with ODPs. There are various modalities of noninvasive and invasive treatment options; however, the best method of treatment is to seal the optic disc to prevent further egress of fluid into the subretinal space. The authors report a technique that involves sealing of ODPs with autologous free flap of the internal limiting membrane (ILM). After trans pars plana vitrectomy, the ILM was peeled and plugged into the ODP...
April 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28413410/eccentric-macular-hole-after-pars-plana-vitrectomy-for-idiopathic-macular-hole-a-case-report
#10
Irini Chatziralli, George Theodossiadis, Maria Douvali, Alexandros A Rouvas, Panagiotis Theodossiadis
INTRODUCTION: Postoperative eccentric macular hole (MH) formation is an uncommon complication after pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling for epiretinal membrane or MH treatment. Herein, we present a case of eccentric MH formation after PPV with ILM peeling for MH. CASE DESCRIPTION: A 72-year-old female patient underwent 23-gauge PPV with ILM peeling for idiopathic MH in her right eye. The visual acuity was 6/24 in the right eye...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28406172/anchored-but-not-internalized-shape-dependent-endocytosis-of-nanodiamond
#11
Bokai Zhang, Xi Feng, Hang Yin, Zhenpeng Ge, Yanhuan Wang, Zhiqin Chu, Helena Raabova, Jan Vavra, Petr Cigler, Renbao Liu, Yi Wang, Quan Li
Nanoparticle-cell interactions begin with the cellular uptake of the nanoparticles, a process that eventually determines their cellular fate. In the present work, we show that the morphological features of nanodiamonds (NDs) affect both the anchoring and internalization stages of their endocytosis. While a prickly ND (with sharp edges/corners) has no trouble of anchoring onto the plasma membrane, it suffers from difficult internalization afterwards. In comparison, the internalization of a round ND (obtained by selective etching of the prickly ND) is not limited by its lower anchoring amount and presents a much higher endocytosis amount...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28402886/three-dimensional-super-resolution-in-eukaryotic-cells-using-the-double-helix-point-spread-function
#12
Alexander R Carr, Aleks Ponjavic, Srinjan Basu, James McColl, Ana Mafalda Santos, Simon Davis, Ernest D Laue, David Klenerman, Steven F Lee
Single-molecule localization microscopy, typically based on total internal reflection illumination, has taken our understanding of protein organization and dynamics in cells beyond the diffraction limit. However, biological systems exist in a complicated three-dimensional environment, which has required the development of new techniques, including the double-helix point spread function (DHPSF), to accurately visualize biological processes. The application of the DHPSF approach has so far been limited to the study of relatively small prokaryotic cells...
April 11, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28402720/insulin-like-growth-factor-binding-protein-related-protein-1-inhibit-retinal-neovascularization-in-the-mouse-model-of-oxygen-induced-retinopathy
#13
Ping Zhang, Hong Wang, Hui Cao, Xun Xu, Tao Sun
PURPOSE: To explore the inhibitory effect of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) on retinal angiogenesis and its underlying molecular mechanisms in the mouse model of oxygen-induced retinopathy (OIR). METHODS: C57BL/6J mice were classified into three groups as control group, OIR nonintervention group, and OIR intervention group. Postnatal day 12 (P12) mice in OIR intervention group were received recombinant mouse IGFBP-rP1 (50, 100, and 200 ng/mL) intravitreal injection...
April 12, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28379543/intra-endosomal-trafficking-mediated-by-lysobisphosphatidic-acid-contributes-to-intracellular-release-of-phosphorothioate-modified-antisense-oligonucleotides
#14
Shiyu Wang, Hong Sun, Michael Tanowitz, Xue-Hai Liang, Stanley T Crooke
Antisense oligonucleotides (ASOs) with phosphorothioate (PS) linkages are broadly used as research tools and therapeutic agents. Chemically modified PS-ASOs can mediate efficient target reduction by site-specific cleavage of RNA through RNase H1. PS-ASOs are known to be internalized via a number of endocytotic pathways and are released from membrane-enclosed endocytotic organelles, mainly late endosomes (LEs). This study was focused on the details of PS-ASO trafficking through endocytic pathways. It was found that lysobisphosphatidic acid (LBPA) is required for release of PS-ASOs from LEs...
April 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28376046/autologous-internal-limiting-membrane-fragment-transplantation-for-rhegmatogenous-retinal-detachment-due-to-paravascular-or-juxtapapillary-retinal-breaks-over-patchy-chorioretinal-atrophy-in-pathologic-myopia
#15
Stanislao Rizzo, Ruggero Tartaro, Francesco Barca, Daniela Bacherini, Fabrizio Franco, Tomaso Caporossi
No abstract text is available yet for this article.
April 3, 2017: Retina
https://www.readbyqxmd.com/read/28376039/residual-intraretinal-edema-after-25-gauge-vitrectomy-and-macular-pucker-removal-is-intraoperative-sustained-release-dexamethasone-a-real-treatment-option
#16
Gianluca Guidi, Giamberto Casini, Guido Ripandelli, Paolo Piaggi, Flavio Dalle Lucche, Mariasole Sartini, Pasquale Loiudice, Francesco Nasini, Mario Stirpe, Stefano Lazzeri
PURPOSE: To investigate the efficacy and safety of intraoperative slow-release dexamethasone implant and 25-gauge (G) vitrectomy plus epiretinal membrane removal in patients affected by idiopathic macular pucker. METHODS: In this randomized, clinical, multicenter study, 60 eyes of 60 pseudophakic eyes having idiopathic macular pucker were enrolled. Thirty eyes underwent 25-G pars plana vitrectomy and internal limiting membrane peeling ("Control group"), whereas 30 eyes underwent 25-G pars plana vitrectomy and internal limiting membrane peeling combined with dexamethasone implant ("DEX group")...
April 3, 2017: Retina
https://www.readbyqxmd.com/read/28374275/postoperative-roll-cake-like-macular-fold-after-retinal-detachment-surgery
#17
Ryusaburo Mori, Hiroyuki Nakashizuka, Yumiko Machida, Hiroyuki Shimada, Mitsuko Yuzawa
PURPOSE: To report a case developing a severe retinal fold (RF), resembling a roll cake on optical coherence tomography (OCT), after retinal detachment (RD) surgery. CASE REPORT: A 61-year-old man underwent vitrectomy for a limited macula-on-superior rhegmatogenous RD and gas tamponade at another hospital. Despite remaining prone for 4 days, RF was noted after gas disappearance and he was referred to us. OCT showed a roll cake-like RF, which resolved after vitrectomy with internal limiting membrane (ILM) peeling, creation of a new detachment, perfluorocarbon liquid injection, air-fluid exchange, silicone oil tamponade and prone positioning...
April 3, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28372729/development-of-a-thermostabilised-triplex-lamp-assay-with-dry-reagent-four-target-lateral-flow-dipstick-for-detection-of-entamoeba-histolytica-and-non-pathogenic-entamoeba-spp
#18
Phiaw Chong Foo, Yean Yean Chan, Maizan Mohamed, Weng Kin Wong, A B Nurul Najian, Boon Huat Lim
This study highlighted the development of a four target nitrocellulose-based nucleic acid lateral flow immunoassay biosensor in a dry-reagent strip format for interpretation of double-labelled double-stranded amplicons from thermostabilised triplex loop-mediated isothermal amplification assay. The DNA biosensor contained two test lines which captured biotin and texas red labelled amplicons; a LAMP internal amplification control line that captured digoxigenin labelled amplicon; and a chromatography control line that validated the functionality of the conjugated gold nanoparticles and membrane...
May 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28362505/radiation-and-internal-loss-engineering-of-high-stress-silicon-nitride-nanobeams
#19
Amir Hossein Ghadimi, Dalziel Joseph Wilson, Tobias J Kippenberg
High-stress Si3N4 nanoresonators have become an attractive choice for electro- and optomechanical devices. Membrane resonators can achieve quality factor (Q)-frequency (f) products exceeding 10(13) Hz, enabling (in principle) quantum coherent operation at room temperature. String-like beam resonators possess smaller Q × f products; however, on account of their significantly lower mass and mode density, they remain a canonical choice for precision force, mass, and charge sensing, and have recently enabled Heisenberg-limited position measurements at cryogenic temperatures...
April 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/28359588/centrifugal-pumps-and-hemolysis-in-pediatric-extracorporeal-membrane-oxygenation-ecmo-patients-an-analysis-of-extracorporeal-life-support-organization-elso-registry-data
#20
Ciaran O'Brien, Julie Monteagudo, Christine Schad, Eva Cheung, William Middlesworth
PURPOSE: It is currently unclear whether centrifugal pumps cause more hemolysis than roller pumps in extracorporeal membrane oxygenation (ECMO) circuits. The aim of this study was to help answer that question in pediatric patients. METHODS: A limited deidentified data set was extracted from the international multicenter Extracorporeal Life Support Organization (ELSO) registry comprising all reported ECMO runs for patients 18years or younger between 2010 and 2015...
March 16, 2017: Journal of Pediatric Surgery
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