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Christina lampe

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https://www.readbyqxmd.com/read/28603410/full-thickness-macular-hole-formation-following-anti-vegf-injections-for-neovascular-age-related-macular-degeneration
#1
Stamatina A Kabanarou, Tina Xirou, George Mangouritsas, Christina Garnavou-Xirou, Eirini Boutouri, Ilias Gkizis, Irini Chatziralli
PURPOSE: Macular hole (MH) is part of a group of age-related degenerative diseases characterized by pathology of vitreomacular interface. Similarly, neovascular age-related macular degeneration (nAMD) affects older patients and is a leading cause of irreversible visual loss. The purpose of this case series is to describe the development of full-thickness MH in patients with nAMD, following antivascular endothelial growth factor (anti-VEGF) treatment. METHODS: Participants in this case series were four patients with nAMD, who received anti-VEGF injections with variable therapeutic response to treatment...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28464188/-lysosomal-storage-diseases-challenges-in-multiprofessional-patient-care-with-enzyme-replacement-therapy
#2
Anibh Martin Das, Florian Lagler, Michael Beck, Maurizio Scarpa, Christina Lampe
Background Due to their rarity studies in (ultra-) rare diseases are difficult. Only for a minority of these diseases causal therapies are available. Development and production of enzyme replacement therapies (ERT) for example are challenging and expensive. The number of patients is low, costs per patient are high. We will focus on the challenges of providing long-term ERT to patients with lysosomal storage diseases (LSD) in an out- and inpatient setting based on a literature search in Pubmed and own experience...
May 2, 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28408707/admixture-mapping-of-subclinical-atherosclerosis-and-subsequent-clinical-events-among-african-americans-in-2-large-cohort-studies
#3
Aditi Shendre, Howard Wiener, Marguerite R Irvin, Degui Zhi, Nita A Limdi, Edgar T Overton, Christina L Wassel, Jasmin Divers, Jerome I Rotter, Wendy S Post, Sadeep Shrestha
BACKGROUND: Local ancestry may contribute to the disproportionate burden of subclinical and clinical cardiovascular disease among admixed African Americans compared with other populations, suggesting a rationale for admixture mapping. METHODS AND RESULTS: We estimated local European ancestry (LEA) using Local Ancestry inference in adMixed Populations using Linkage Disequilibrium method (LAMP-LD) and evaluated the association with common carotid artery intima-media thickness (cCIMT) using multivariable linear regression analysis among 1554 African Americans from MESA (Multi-Ethnic Study of Atherosclerosis)...
April 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28196403/morphologic-patterns-formed-by-the-anomalous-fibers-occurring-along-the-anterior-capsule-of-the-crystalline-lens-in-people-with-the-long-anterior-zonule-trait
#4
Daniel K Roberts, Yongyi Yang, Christina E Morettin, Tricia L Newman, Mary F Roberts, Jacob T Wilensky
People with the long anterior zonule (LAZ) trait, which may have prevalence near 2%, have zonular fibers that extend more central than usual along the anterior capsule of the crystalline lens. The anomalous fibers can be observed in vivo with clinical slit lamp biomicroscopy after pharmacologic pupil dilation, and although minimally studied, the LAZ trait may have importance to glaucoma, retinal degeneration, and cataract surgery. To further characterize LAZ morphology, a custom computer program was used to trace LAZ fibers seen on retro-illumination photos acquired during previous study at an academic, urban eye care facility in Chicago, IL...
July 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28183348/optimized-creation-of-glioblastoma-patient-derived-xenografts-for-use-in-preclinical-studies
#5
Doreen William, Christina Susanne Mullins, Björn Schneider, Andrea Orthmann, Nora Lamp, Mathias Krohn, Annika Hoffmann, Carl-Friedrich Classen, Michael Linnebacher
BACKGROUND: Glioblastoma multiforme (GBM) is the most common and lethal brain tumor in adults, highlighting the need for novel treatment strategies. Patient derived xenografts (PDX) represent a valuable tool to accomplish this task. METHODS: PDX were established by implanting GBM tissue subcutaneously. Engraftment success was compared between NMRI Foxn1(nu) and NOD/SCID as well as between fresh and cryopreserved tissue. Established PDX were analyzed histologically and molecularly...
February 9, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28093642/the-ethical-framework-for-performing-research-with-rare-inherited-neurometabolic-disease-patients
#6
REVIEW
Viviana Giannuzzi, Hugo Devlieger, Lucia Margari, Viveca Lena Odlind, Lamis Ragab, Cinzia Maria Bellettato, Francesca D'Avanzo, Christina Lampe, Linda Cassis, Elisenda Cortès-Saladelafont, Ángels Garcia Cazorla, Ivo Barić, Ljerka Cvitanović-Šojat, Ksenija Fumić, Christine I Dali, Franco Bartoloni, Fedele Bonifazi, Maurizio Scarpa, Adriana Ceci
The need for performing clinical trials to develop well-studied and appropriate medicines for inherited neurometabolic disease patients faces ethical concerns mainly raising from four aspects: the diseases are rare; include young and very young patients; the neurological impairment may compromise the capability to provide 'consent'; and the genetic nature of the disease leads to further ethical implications. This work is intended to identify the ethical provisions applicable to clinical research involving these patients and to evaluate if these cover the ethical issues...
March 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27992230/ph-and-potential-transients-of-the-bc1-complex-co-reconstituted-in-proteo-lipobeads-with-the-reaction-center-from-rb-sphaeroides
#7
Andreas F Geiss, Raghav Khandelwal, Dieter Baurecht, Christina Bliem, Ciril Reiner-Rozman, Michael Boersch, G Matthias Ullmann, Leslie M Loew, Renate L C Naumann
His-tag technology is employed to bind membrane proteins, such as the bc1 complex and the reaction center (RC) from Rhodobacter sphaeroides, to spherical as well as planar surfaces in a strict orientation. Subsequently, the spherical and planar surfaces are subjected to in situ dialysis to form proteo-lipobeads (PLBs) and protein-tethered bilayer membranes, respectively. PLBs based on Ni-nitrileotriacetic acid-functionalized agarose beads that have diameters ranging from 50 to 150 μm are used to assess proton release and membrane potential parameters by confocal laser-scanning microscopy...
January 4, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27809869/erratum-to-review-and-evaluation-of-the-methodological-quality-of-the-existing-guidelines-and-recommendations-for-inherited-neurometabolic-disorders
#8
Linda Cassis, Elisenda Cortès-Saladelafont, Marta Molero-Luis, Delia Yubero, Maria Julieta González, Aida Ormazábal, Carme Fons, Cristina Jou, Cristina Sierra, Esperanza Castejon Ponce, Federico Ramos, Judith Armstrong, M Mar O'Callaghan, Mercedes Casado, Raquel Montero, Silvia Meavilla-Olivas, Rafael Artuch, Ivo Barić, Franco Bartoloni, Cinzia Maria Bellettato, Fedele Bonifazi, Adriana Ceci, Ljerka Cvitanović-Šojat, Christine I Dali, Francesca D'Avanzo, Ksenija Fumic, Viviana Giannuzzi, Christina Lampe, Maurizio Scarpa, Ángels Garcia-Cazorla
No abstract text is available yet for this article.
November 3, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27610627/heart-and-cardiovascular-involvement-in-patients-with-mucopolysaccharidosis-type-iva-morquio-a-syndrome
#9
Christoph Kampmann, Tariq Abu-Tair, Seyfullah Gökce, Christina Lampe, Jörg Reinke, Eugen Mengel, Julia B Hennermann, Christiane M Wiethoff
BACKGROUND: Mucopolysaccharidosis (MPS) IVA is a rare lysosomal storage disorder with multiple skeletal and non-skeletal abnormalities requiring multiple surgical interventions. It is well known that patients with MPS IVA suffer from tachycardia, but cardiac and hemodynamic alterations have not been reported to date. We investigated the cardiovascular and hemodynamic alterations in patients with MPS IVA and developed a possible patho-mechanism for cardiovascular deterioration during anesthesia...
2016: PloS One
https://www.readbyqxmd.com/read/27561270/health-related-quality-of-life-in-mucopolysaccharidosis-looking-beyond-biomedical-issues
#10
REVIEW
Christian J Hendriksz, Kenneth I Berger, Christina Lampe, Susanne G Kircher, Paul J Orchard, Rebecca Southall, Sarah Long, Stephen Sande, Jeffrey I Gold
The mucopolysaccharidoses (MPS) comprise a heterogeneous family of rare, genetic lysosomal storage disorders that result in severe morbidity and reduced life expectancy. Emerging treatments for several of these disorders have triggered the search for clinically relevant biomarkers and clinical markers associated with treatment efficacy in populations and individuals. However, biomedical measures do not tell the whole story when characterizing a complex chronic disorder such as MPS. Health-related quality of life (HRQoL) tools that utilize patient reported outcomes to address patient parameters such as symptoms (pain, fatigue, psychological health), functioning (activity and limitations), or quality of life, have been used to supplement traditional biomedical endpoints...
August 26, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27432811/the-lived-environment-life-quality-model-for-institutionalized-people-with-dementia-le-lived-environment-life-quality-model-pour-intervenir-dans-les-%C3%A3-tablissements-de-soins-aupr%C3%A3-s-des-personnes-atteintes-d-une-d%C3%A3-mence
#11
Wendy Wood, Jenna L Lampe, Christina A Logan, Amy R Metcalfe, Beth E Hoesly
BACKGROUND: There is a need for a conceptual practice model that explicates ecological complexities involved in using occupation to optimize the quality of life of institutionalized people with dementia. PURPOSE: This study aimed to prepare the Lived Environment Life Quality Model, a dementia-specific conceptual practice model of occupational therapy in institutional facilities, for publication and application to practice. METHOD: Interviews and focus groups with six expert occupational therapists were subjected to qualitative content analysis to confirm, disconfirm, and further develop the model...
July 18, 2016: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://www.readbyqxmd.com/read/27339555/cervical-cord-compression-in-mucopolysaccharidosis-vi-mps-vi-findings-from-the-mps-vi-clinical-surveillance-program-csp
#12
Guirish A Solanki, Peter P Sun, Kenneth W Martin, Christian J Hendriksz, Christina Lampe, Nathalie Guffon, Annie Hung, Zlatko Sisic, Renée Shediac, Paul R Harmatz
OBJECTIVES: To gain insight into the frequency, age of onset, and management of cervical cord compression in mucopolysaccharidosis VI (MPS VI). METHODS: Cervical spine magnetic resonance imaging (MRI) data and/or cervical decompression surgery data collected between 30 June 2005 and 1 September 2015 were analyzed from subjects enrolled in the MPS VI Clinical Surveillance Program (CSP) (ClinicalTrials.gov: NCT00214773), an ongoing multicenter, observational, retrospective and prospective registry...
August 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/26762268/sphingosine-1-phosphate-reduces-ischaemia-reperfusion-injury-by-phosphorylating-the-gap-junction-protein-connexin43
#13
Sandrine Morel, Christina Christoffersen, Lene N Axelsen, Fabrizio Montecucco, Viviane Rochemont, Miguel A Frias, Francois Mach, Richard W James, Christian C Naus, Marc Chanson, Paul D Lampe, Morten S Nielsen, Lars B Nielsen, Brenda R Kwak
AIM: Increasing evidence points to lipoprotein composition rather than reverse cholesterol transport in the cardioprotective properties of high-density lipoproteins (HDLs). HDL binding to receptors at the surface of cardiomyocytes activates signalling pathways promoting survival, but downstream targets are largely unknown. Here, we investigate the pathways by which the sphingosine-1-phosphate (S1P) constituent of HDL limits cell death induced by cardiac ischaemia-reperfusion (I/R). METHODS AND RESULTS: Apolipoprotein M (ApoM) transgenic (Apom-Tg) mice, in which plasma S1P is increased by 296%, and wild-type (WT) mice were subjected to in vivo I/R...
March 1, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/26414225/neutropenic-enterocolitis-new-insights-into-a-deadly-entity
#14
MULTICENTER STUDY
Taha Sachak, Michael A Arnold, Bita V Naini, Rondell P Graham, Sejal S Shah, Michael Cruise, Jason Y Park, Lindsey Clark, Laura Lamps, Wendy L Frankel, Nicole Theodoropoulos, Christina A Arnold
Neutropenic enterocolitis (NE) is a deadly ileocecal-based disease seen in patients with a recent history of chemotherapy. As histology is not included in the current diagnostic criteria, the pathologic features of NE are poorly understood. We undertook a multi-institutional study of NE, and report helpful clinical clues, such as immunosuppression (n=20/20), recent chemotherapy (n=17/18), neutropenia (n=16/18) gastrointestinal symptoms (n=19/19), abnormal imaging studies of the cecum/right colon (n=11/14), and positive microbiological studies (n=13/15)...
December 2015: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26411728/immunolocalization-of-cell-wall-carbohydrate-epitopes-in-seaweeds-presence-of-land-plant-epitopes-in-fucus-vesiculosus-l-phaeophyceae
#15
Sandra Cristina Raimundo, Utku Avci, Christina Hopper, Sivakumar Pattathil, Michael G Hahn, Zoë A Popper
Land plant cell wall glycan epitopes are present in Fucus vesiculosus. RG-I/AG mAbs recognize distinct glycan epitopes in structurally different galactans, and 3-linked glucans are also present in the cell walls. Cell wall-directed monoclonal antibodies (mAbs) have given increased knowledge of fundamental land plant processes but are not extensively used to study seaweeds. We profiled the brown seaweed Fucus vesiculosus glycome employing 155 mAbs that recognize predominantly vascular plant cell wall glycan components...
February 2016: Planta
https://www.readbyqxmd.com/read/26317991/comparison-of-rebound-tonometry-perkins-applanation-tonometry-and-ocular-response-analyser-in-mucopolysaccharidosis-patients
#16
COMPARATIVE STUDY
Joanna Wasielica-Poslednik, Christina Butsch, Christina Lampe, Heike Elflein, Julia Lamparter, Veronika Weyer, Susanne Pitz
AIMS: To investigate the feasibility and to compare three devices measuring intraocular pressure (IOP) in mucopolysaccharidosis patients (MPS): iCare rebound tonometer (RT), Perkins applanation tonometer (PAT) and ocular response analyzer (ORA). METHODS: MPS patients who underwent at least two examinations out of: RT, PAT and ORA at the same visit were identified and retrospectively analyzed in this study. RESULTS: 17 patients fulfilled the inclusion criterion...
2015: PloS One
https://www.readbyqxmd.com/read/26153146/iroll-does-3-d-radioguided-occult-lesion-localization-improve-surgical-management-in-early-stage-breast-cancer
#17
Christina Bluemel, Andreas Cramer, Christoph Grossmann, Georg W Kajdi, Uwe Malzahn, Nora Lamp, Heinz-Jakob Langen, Jan Schmid, Andreas K Buck, Hanns-Jörg Grimminger, Ken Herrmann
PURPOSE: To prospectively evaluate the feasibility of 3-D radioguided occult lesion localization (iROLL) and to compare iROLL with wire-guided localization (WGL) in patients with early-stage breast cancer undergoing breast-conserving surgery and sentinel lymph node biopsy (SLNB). METHODS: WGL (standard procedure) and iROLL in combination with SLNB were performed in 31 women (mean age 65.1 ± 11.2 years) with early-stage breast cancer and clinically negative axillae...
October 2015: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/25987170/neuronopathic-lysosomal-storage-disorders-approaches-to-treat-the-central-nervous-system
#18
REVIEW
Maurizio Scarpa, Cinzia Maria Bellettato, Christina Lampe, David J Begley
Pharmacological research has always focused on developing new therapeutic strategies capable of modifying a disease's natural history and improving patients' quality of life. Despite recent advances within the fields of medicine and biology, some diseases still represent a major challenge for successful therapy. Neuronopathic lysosomal storage disorders, in particular, have high rates of morbidity and mortality and a devastating socio-economic effect. Many of the available therapies, such as enzyme replacement therapy, can reverse the natural history of the disease in peripheral organs but, unfortunately, are still unable to reach the central nervous system effectively because they cannot cross the blood-brain barrier that surrounds and protects the brain...
March 2015: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/25393894/posterior-capsular-opacification-and-nd-yag-capsulotomy-rates-with-the-imics-y-60h-and-micro-ay-intra-ocular-lenses-3-year-results-of-a-randomized-clinical-trial
#19
RANDOMIZED CONTROLLED TRIAL
Sabine M Schriefl, Christina Leydolt, Eva Stifter, Rupert Menapace
PURPOSE: To compare the incidence and intensity of posterior capsular opacification (PCO) and neodymium:yttrium-aluminium-garnet (Nd:YAG) capsulotomy rates between two microincision intra-ocular lenses (IOLs) 3 years after surgery. METHODS: Sixty-five patients randomly received a Y-60H IOL (HOYA Surgical Optics, Singapore) in one eye and a Micro AY IOL (PhysIOL, Liège, Belgium) in the contralateral eye during same-day bilateral cataract surgery. Eyes were examined 1 week, 20 months and 3 years after surgery...
June 2015: Acta Ophthalmologica
https://www.readbyqxmd.com/read/24764221/natural-history-and-galsulfase-treatment-in-mucopolysaccharidosis-vi-mps-vi-maroteaux-lamy-syndrome-10-year-follow-up-of-patients-who-previously-participated-in-an-mps-vi-survey-study
#20
MULTICENTER STUDY
Roberto Giugliani, Christina Lampe, Nathalie Guffon, David Ketteridge, Elisa Leão-Teles, James E Wraith, Simon A Jones, Cheri Piscia-Nichols, Ping Lin, Adrian Quartel, Paul Harmatz
Mucopolysaccharidosis VI (MPS VI) is a clinically heterogeneous and progressive disorder with multiorgan manifestations caused by deficient N-acetylgalactosamine-4-sulfatase activity. A cross-sectional Survey Study in individuals (n = 121) affected with MPS VI was conducted between 2001 and 2002 to establish demographics, urinary glycosaminoglycan (GAG) levels, and clinical progression of disease. We conducted a Resurvey Study (ClinicalTrials.gov: NCT01387854) to obtain 10-year follow-up data, including medical histories and clinical assessments (n = 59), and survival status over 12 years (n = 117)...
August 2014: American Journal of Medical Genetics. Part A
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