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Tetracaine

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https://www.readbyqxmd.com/read/29742927/tetracaine-induces-apoptosis-through-a-mitochondrion-dependent-pathway-in-human-corneal-stromal-cells-in-vitro
#1
Zhan Song, Ting-Jun Fan
PURPOSE: Tetracaine is a local anesthetic widely used in ocular diagnosis and ophthalmic surgery and may lead to some adverse effects and complications at a clinical dose. To assess the cytotoxicity and molecular toxicity mechanisms of tetracaine, we used human corneal stromal (HCS) cells as an in vitro model to study the effects of tetracaine on HCS cells. MATERIALS AND METHODS: The cytotoxicity of tetracaine on HCS cells was investigated by examining the changes of cell growth, morphology, viability and cell cycle progressing when HCS cells were treated with tetracaine at concentrations from 10 g/L to 0...
May 9, 2018: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29601618/the-use-of-a-self-occluding-topical-anasthetic-in-daily-practice-a-non-interventional-study
#2
Ravi Jain, Gerardo Moreno Arias, Pablo Naranjo, Max Murison, Jose Luis López Estebaranz, Alina Fratila, Welf Prager, Carlos Guillén Barona, Michael Weidmann, Serge Dahan, Hugues Cartier, Gerhard Sattler, Maurizio Podda
INTRODUCTION: A variety of topical anesthetic creams are available to reduce pain associated with dermatological procedures. Pliaglis is a self-occluding eutectic mixture of lidocaine and tetracaine. STUDY OBJECTIVES: To evaluate the post-marketing safety profile of Pliaglis and efficacy in terms of pain reduction, product satisfaction, and daily practice use prior to pre-defined dermatological procedures. METHODS: A prospective, non-interventional study conducted at 44 sites in four European countries; 581 patients were treated prior to dermatological procedures such as pulsed-dye laser therapy, laser-assisted hair removal, non-ablative laser resurfacing, dermal filler injections, and vascular access...
April 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29530656/tetracaine-challenges-old-dogma-for-emergency-department-management-of-corneal-abrasion-pain-and-beckons-a-definitive-study
#3
EDITORIAL
Brennan M Boyd, Robert Snyder
No abstract text is available yet for this article.
June 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29525621/lipid-mediated-mode-of-action-of-local-anesthetics-on-lipid-pores-induced-by-polyenes-peptides-and-lipopeptides
#4
Svetlana S Efimova, Evgeny G Chulkov, Olga S Ostroumova
The effects of local anesthetics (LAs), namely, lidocaine (LDC), prilocaine (PLC), mepivacaine (MPV), bupivacaine (BPV), procaine (PC), and tetracaine (TTC), on the steady-state transmembrane conductance induced by the cis-side addition of the antifungal polyene macrolide antibiotic, nystatin (NYS), in planar lipid bilayers were studied. The addition of TTC to model membranes comprising DOPC and cholesterol (33 mol%) led to a nearly twenty-fold increase in the steady-state NYS-induced membrane conductance...
June 1, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29415859/effects-of-transdermal-lidocaine-or-lidocaine-with-prilocaine-or-tetracaine-on-mechanical-superficial-sensation-and-nociceptive-thermal-thresholds-in-horses
#5
Franz J Söbbeler, Sabine Br Kästner
OBJECTIVE: To evaluate the transdermal local anaesthetic effect of lidocaine or lidocaine combined with prilocaine or tetracaine in horses. STUDY DESIGN: Experimental, randomized study. ANIMALS: A total of five healthy adult warmblood horses. METHODS: Horses were clipped bilaterally at the withers, cranial saddle area and caudal saddle area. Baseline measurements for mechanical superficial sensation via von Frey filaments and nociceptive thermal thresholds were performed...
March 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29410362/tetracaine-derivatives-for-catecholaminergic-polymorphic-ventricular-tachycardia-new-drugs-for-correction-of-diastolic-ca-2-leak
#6
EDITORIAL
Héctor H Valdivia, Carmen R Valdivia
No abstract text is available yet for this article.
April 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29401432/dynamic-and-irregular-distribution-of-ryr2-clusters-in-the-periphery-of-live-ventricular-myocytes
#7
Florian Hiess, Pascal Detampel, Carme Nolla-Colomer, Alex Vallmitjana, Anutosh Ganguly, Matthias Amrein, Henk E D J Ter Keurs, Raul Benítez, Leif Hove-Madsen, S R Wayne Chen
Cardiac ryanodine receptors (RyR2s) are Ca2+ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2+ release. The distribution of these Ca2+ release units plays a critical role in determining the spatio-temporal profile and stability of sarcoplasmic reticulum Ca2+ release. RyR2 clusters located in the interior of cardiomyocytes are arranged in highly ordered arrays. However, little is known about the distribution and function of RyR2 clusters in the periphery of cardiomyocytes...
January 23, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29383731/ca-2-signalling-in-mouse-urethral-smooth-muscle-in-situ-role-of-ca-2-stores-and-ca-2-influx-mechanisms
#8
Bernard T Drumm, Benjamin E Rembetski, Caroline A Cobine, Salah A Baker, Gerard P Sergeant, Mark A Hollywood, Keith D Thornbury, Kenton M Sanders
KEY POINTS: Contraction of urethral smooth muscle cells (USMCs) contributes to urinary continence. Ca2+ signalling in USMCs was investigated in intact urethral muscles using a genetically encoded Ca2+ sensor, GCaMP3, expressed selectively in USMCs. USMCs were spontaneously active in situ, firing intracellular Ca2+ waves that were asynchronous at different sites within cells and between adjacent cells. Spontaneous Ca2+ waves in USMCs were myogenic but enhanced by adrenergic or purinergic agonists and decreased by nitric oxide...
April 15, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29319604/the-european-society-of-regional-anaesthesia-and-pain-therapy-american-society-of-regional-anesthesia-and-pain-medicine-recommendations-on-local-anesthetics-and-adjuvants-dosage-in-pediatric-regional-anesthesia
#9
Santhanam Suresh, Claude Ecoffey, Adrian Bosenberg, Per-Anne Lonnqvist, Gildasio S de Oliveira, Oscar de Leon Casasola, José de Andrés, Giorgio Ivani
BACKGROUND AND OBJECTIVES: Dosage of local anesthetics (LAs) used for regional anesthesia in children is not well determined. In order to evaluate and come to a consensus regarding some of these controversial topics, The European Society of Regional Anaesthesia and Pain Therapy (ESRA) and the American Society of Regional Anesthesia and Pain Medicine (ASRA) developed a Joint Committee Practice Advisory on Local Anesthetics and Adjuvants Dosage in Pediatric Regional Anesthesia. METHODS: Representatives from both ASRA and ESRA composed the joint committee practice advisory...
February 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29289652/cellular-mechanisms-of-metabolic-syndrome-related-atrial-decompensation-in-a-rat-model-of-hfpef
#10
Felix Hohendanner, David Bode, Uwe Primessnig, Tim Guthof, Rafael Doerr, Sarah Jeuthe, Sophie Reimers, Kun Zhang, Doris Bach, Paulina Wakula, Burkert M Pieske, Frank R Heinzel
Heart failure (HF) with preserved ejection fraction (HFpEF) is present in about 50% of HF patients. Atrial remodeling is common in HFpEF and associated with increased mortality. We postulate that atrial remodeling is associated with atrial dysfunction in vivo related to alterations in cardiomyocyte Calcium (Ca) signaling and remodeling. We examined atrial function in vivo and Ca transients (CaT) (Fluo4-AM, field stim) in atrial cardiomyocytes of ZSF-1 rats without (Ln; lean hypertensive) and with metabolic syndrome (Ob; obese, hypertensive, diabetic) and HFpEF...
February 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29248564/el20-a-potent-antiarrhythmic-compound-selectively-inhibits-calmodulin-deficient-ryanodine-receptor-type-2
#11
Robert C Klipp, Na Li, Qiongling Wang, Tarah A Word, Martha Sibrian-Vazquez, Robert M Strongin, Xander H T Wehrens, Jonathan J Abramson
BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmogenic disorder caused by mutations in the cardiac ryanodine receptor RyR2 that increase diastolic calcium cation (Ca2+ ) leak from the sarcoplasmic reticulum (SR). Calmodulin (CaM) dissociation from RyR2 has been associated with diastolic Ca2+ leak in heart failure. OBJECTIVE: Determine whether the tetracaine-derivative compound EL20 inhibits abnormal Ca2+ release from RyR2 in a CPVT model and investigate the underlying mechanism of inhibition...
April 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29236279/the-maxillary-nerve-block-for-in-office-hybrid-balloon-sinus-dilation-procedures-a-preliminary-study
#12
Gary J Nishioka
Transitioning of rhinologic procedures from the operating room to the office setting in selected patients is a rising trend. An effective pain-control, patient-preparation protocol is essential, especially with advanced in-office rhinologic procedures such as hybrid balloon sinus dilation (BSD), in which other procedures such as ethmoidectomy, turbinate reduction, and other procedures are concomitantly performed. A regimen using oral sedation, topical tetracaine gel, topical tetracaine/epinephrine-soaked cottonoid packs, and intranasal local infiltrative anesthesia can vary significantly in effectiveness and be suboptimal at times (as determined by using treated patients as historical controls)...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29203420/compound-action-potential-inhibition-produced-by-various-antidepressants-in-the-frog-sciatic-nerve
#13
Ryo Hirao, Tsugumi Fujita, Aiko Sakai, Eiichi Kumamoto
Although an inhibition of action potential conduction in nerve fibers possibly contributes to at least a part of antinociception produced by analgesics and the adjuvants, it has not been fully examined yet how the conduction inhibition differs in extent among their drugs. We investigated the effects of various antidepressants used as analgesic adjuvants on compound action potentials (CAPs) recorded from the frog sciatic nerve by using the air-gap method. The results were compared with those of the other adjuvants that were reported previously...
January 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29184841/evaluation-of-the-anesthetic-effect-of-nasal-mucosa-with-tetracaine-0-5-on-hemodynamic-changes-and-postoperative-pain-of-septoplasty-a-randomized-controlled-trial
#14
Hossein Madineh, Soroush Amani, Majid Kabiri, Behnam Karimi
The nasal septum repair surgery is the dangerous operations that any stimulation of this area causes a large change in the rhythm of the heartbeat and blood pressure. This study aimed to determine the effects of tetracaine 0.5% on changes in heartbeat and heart rhythm, hemodynamic changes during surgery, intraoperative bleeding, and pain after septoplasty surgery. The irregular double-blind clinical trial registry of clinical trials Iran with the code number (IRCT: 20150526625N8) in the first half of 2013 on 86 patients in Kashani hospital of Shahrekord...
October 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29150444/toll-like-receptor-4-induced-ryanodine-receptor-2-oxidation-and-sarcoplasmic-reticulum-ca-2-leakage-promote-cardiac-contractile-dysfunction-in-sepsis
#15
Jie Yang, Rui Zhang, Xin Jiang, Jingzhang Lv, Ying Li, Hongyu Ye, Wenjuan Liu, Gang Wang, Cuicui Zhang, Na Zheng, Ming Dong, Yan Wang, Peiya Chen, Kumar Santosh, Yong Jiang, Jie Liu
Studies suggest the potential role of a sarcoplasmic reticulum (SR) Ca2+ leak in cardiac contractile dysfunction in sepsis. However, direct supporting evidence is lacking, and the mechanisms underlying this SR leak are poorly understood. Here, we investigated the changes in cardiac Ca2+ handling and contraction in LPS-treated rat cardiomyocytes and a mouse model of polymicrobial sepsis produced by cecal ligation and puncture (CLP). LPS decreased the systolic Ca2+ transient and myocyte contraction as well as SR Ca2+ content...
January 19, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29091806/electrochemical-fenton-based-treatment-of-tetracaine-in-synthetic-and-urban-wastewater-using-active-and-non-active-anodes
#16
Carlota Ridruejo, Francesc Centellas, Pere L Cabot, Ignasi Sirés, Enric Brillas
The electrochemical degradation of tetracaine hydrochloride has been studied in urban wastewater. Treatments in simulated matrix with similar ionic composition as well as in 0.050 M Na2 SO4 were comparatively performed. The cell contained an air-diffusion cathode for H2 O2 electrogeneration and an anode selected among active Pt, IrO2 -based and RuO2 -based materials and non-active boron-doped diamond (BDD). Electrochemical oxidation with electrogenerated H2 O2 (EO-H2 O2 ), electro-Fenton (EF) and photoelectro-Fenton (PEF) were comparatively assessed at pH 3...
January 1, 2018: Water Research
https://www.readbyqxmd.com/read/29069016/topical-cryoanesthesia-for-the-relief-of-pain-caused-by-steroid-injections-used-to-treat-hypertrophic-scars-and-keloids
#17
RANDOMIZED CONTROLLED TRIAL
Xiuxia Wang, Xiaoli Wu, Ke Liu, Lingling Xia, Xunxun Lin, Wei Liu, Zhen Gao
Intralesional steroid injections are the standard treatment for hypertrophic scars and keloids. The procedure is, however, quite painful and is unpopular with patients because of this. Topical application of anesthetic creams, such as Ametop gel (tetracaine) and EMLA cream (lidocaine and prilocaine), has limited efficacy because of poor drug penetration. The onset of the analgesic effect is also slow, which means that the use of topical anesthetics is time-consuming in clinical practice.We hypothesized that a commercially available cryotip could be used to provide fast-acting topical cryoanesthesia that would reduce the pain associated with steroid injections...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28978899/subarachnoid-block-induced-deafferentation-pain-successfully-treated-with-pentazocine
#18
Hiroaki Kishikawa, Zen'ichiro Wajima, Toshiro Shitara, Toru Shimizu, Hitoshi Adachi, Atsuhiro Sakamoto
Deafferentation pain induced by subarachnoid block (SAB) is rare, but it can appear in the form of recurrent phantom lower limb pain, new acute-onset stump pain in amputees, lower limb pain in patients with tabes dorsalis, and neuropathic pain. We have previously reported that thiopental is an effective treatment for deafferentation pain induced by therapeutic SAB applied to treat neuropathic pain of central origin. Here, we report the case of an amputee who developed new stump pain in his lower limb immediately after subarachnoid tetracaine was administered prior to appendectomy...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28943117/lack-of-methemoglobin-elevations-after-topical-applications-of-benzocaine-alone-or-benzocaine-plus-tetracaine-to-the-oral-mucosa
#19
RANDOMIZED CONTROLLED TRIAL
Steven Wang, Helen Giannakopoulos, Jamie Lowstetter, Laura Kaye, Catherine Lee, Stacey Secreto, Vanessa Ho, Matthew C Hutcheson, John T Farrar, Ping Wang, Geraldine Doyle, Stephen A Cooper, Elliot V Hersh
PURPOSE: This study evaluated changes in methemoglobin and oxygen saturation concentrations after the administration of recommended doses of 14% benzocaine alone or 14% benzocaine combined with 2% tetracaine. METHODS: American Society of Anesthesiology class 1 and 2 subjects (n = 40) were enrolled in this modified crossover study. Subjects were administered 0.2 mL of 14% benzocaine alone, 0.2 mL of 14% benzocaine plus 2% tetracaine, or 0.4 mL of 14% benzocaine plus 0...
October 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28881348/accelerating-topical-anaesthesia-using-microneedles
#20
Lleucu B Davies, Christopher Gateley, Phillip Holland, Siôn A Coulman, James C Birchall
BACKGROUND/AIMS: Topical anaesthetics reduce pain during venous access procedures in children. However, clinical use is hindered by a significant anaesthetic onset time. Restricted diffusion of the topical anaesthetic through the stratum corneum barrier is the principal reason for the delayed onset. Microneedles can painlessly pierce the skin. This study evaluated microneedle pre-treatment of ex vivo human skin as a means to increase the rate of tetracaine permeation, in order to accelerate the onset of anaesthesia...
2017: Skin Pharmacology and Physiology
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