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https://www.readbyqxmd.com/read/28943117/lack-of-methemoglobin-elevations-after-topical-applications-of-benzocaine-alone-or-benzocaine-plus-tetracaine-to-the-oral-mucosa
#1
Steven Wang, Helen Giannakopoulos, Jamie Lowstetter, Laura Kaye, Catherine Lee, Stacey Secreto, Vanessa Ho, Matthew C Hutcheson, John T Farrar, Ping Wang, Geraldine Doyle, Stephen A Cooper, Elliot V Hersh
PURPOSE: This study evaluated changes in methemoglobin and oxygen saturation concentrations after the administration of recommended doses of 14% benzocaine alone or 14% benzocaine combined with 2% tetracaine. METHODS: American Society of Anesthesiology class 1 and 2 subjects (n = 40) were enrolled in this modified crossover study. Subjects were administered 0.2 mL of 14% benzocaine alone, 0.2 mL of 14% benzocaine plus 2% tetracaine, or 0.4 mL of 14% benzocaine plus 0...
September 21, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28881348/accelerating-topical-anaesthesia-using-microneedles
#2
Lleucu B Davies, Christopher Gateley, Phillip Holland, Siôn A Coulman, James C Birchall
BACKGROUND/AIMS: Topical anaesthetics reduce pain during venous access procedures in children. However, clinical use is hindered by a significant anaesthetic onset time. Restricted diffusion of the topical anaesthetic through the stratum corneum barrier is the principal reason for the delayed onset. Microneedles can painlessly pierce the skin. This study evaluated microneedle pre-treatment of ex vivo human skin as a means to increase the rate of tetracaine permeation, in order to accelerate the onset of anaesthesia...
September 8, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28868303/adjuvants-to-local-anesthetics-current-understanding-and-future-trends
#3
EDITORIAL
Amlan Swain, Deb Sanjay Nag, Seelora Sahu, Devi Prasad Samaddar
Although beneficial in acute and chronic pain management, the use of local anaesthetics is limited by its duration of action and the dose dependent adverse effects on the cardiac and central nervous system. Adjuvants or additives are often used with local anaesthetics for its synergistic effect by prolonging the duration of sensory-motor block and limiting the cumulative dose requirement of local anaesthetics. The armamentarium of local anesthetic adjuvants have evolved over time from classical opioids to a wide array of drugs spanning several groups and varying mechanisms of action...
August 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28680703/patient-pain-during-intravitreal-injections-under-topical-anesthesia-a-systematic-review
#4
Helio Francisco Shiroma, Augusto Key Karazawa Takaschima, Michel Eid Farah, Ana Luisa Höfling-Lima, Graziela de Luca Canto, Roberto Henrique Benedetti, Eduardo Buchele Rodrigues
BACKGROUND: Intravitreal injection (IVI) is a very common vitreoretinal procedure, and multiple injections are often required per patient. This systematic review was conducted to evaluate the effectiveness of various local anesthetic techniques in reducing pain during injection. METHODS: A systematic review was conducted based on searches of Cochrane, LILACS, PubMed, Scopus, Web of Science, and the gray literature (Google Scholar). The end search date was February 19, 2016, across all databases...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28661445/thermal-stability-of-phase-separated-domains-in-multicomponent-lipid-membranes-with-local-anesthetics
#5
Ko Sugahara, Naofumi Shimokawa, Masahiro Takagi
The functional mechanisms of local anesthetics (LAs) have not yet been fully explained, despite their importance in modern medicine. Recently, an indirect interaction between channel proteins and LAs was proposed as follows: LAs alter the physical properties of lipid membranes, thus affecting the channel proteins. To examine this hypothesis, we investigated changes in thermal stability in lipid membranes consisting of dioleoylphosphocholine, dipalmitoylphosphocholine, and cholesterol by adding the LAs, lidocaine and tetracaine...
June 29, 2017: Membranes
https://www.readbyqxmd.com/read/28651726/tetracaine-is-not-more-effective-than%C3%A2-benzocaine-for-preventing-discomfort-in-young-infants-undergoing-frenotomy
#6
Romina Brignardello-Petersen
No abstract text is available yet for this article.
July 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28626826/adverse-drug-events-leading-to-emergency-department-visits-at-an-eye-hospital-a-brief-report
#7
Safa Alizadeh, Niayesh Mohebbi, Kheirollah Gholami, Mahmoud Jabbarvand
PURPOSE: To evaluate adverse drug events (ADEs) resulting in emergency department visits in an eye hospital. METHOD: Emergency department visits at Farabi Eye Hospital were assessed for a 7-day period. The patients' eye disorders and drug history were evaluated to detect ADEs. RESULTS: Of 1631 emergency visits, 5 (0.3%, 95% CI: 0.13-0.71%) were drug related. Tetracaine eye drops accounted for 4 (80%, 95% CI: 38-96%) cases with corneal involvement...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28568606/coupling-of-excitation-to-ca-2-release-is-modulated-by-dysferlin
#8
Valeriy Lukyanenko, Joaquin M Muriel, Robert J Bloch
KEY POINTS: Dysferlin, the protein missing in limb girdle muscular dystrophy 2B and Miyoshi myopathy, concentrates in transverse tubules of skeletal muscle, where it stabilizes voltage-induced Ca(2+) transients against loss after osmotic shock injury (OSI). Local expression of dysferlin in dysferlin-null myofibres increases transient amplitude to control levels and protects them from loss after OSI. Inhibitors of ryanodine receptors (RyR1) and L-type Ca(2+) channels protect voltage-induced Ca(2+) transients from loss; thus both proteins play a role in injury in dysferlin's absence...
August 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28521706/fibrinous-anterior-uveitis-and-recurrent-epithelial-erosion-following-topical-tetracaine-abuse
#9
Olga E Makri, Panagiotis Plotas, Foteini Tsapardoni, Ilias Georgalas, Constantinos D Georgakopoulos
A 54-year-old man presented complaining of severe pain and blurred vision in his left eye. Slit-lamp biomicroscopy revealed a large epithelial defect with an underlying prominent ring infiltrate and severe anterior uveitis with fibrinous exudates and hypopyon. Patient admitted abuse of topical tetracaine, which was discontinued and topical treatment with a non-steroidal anti-inflammatory agent, an antibiotic, a cycloplegic agent were instituted while a therapeutic contact lens was applied. Response to treatment was favorable with a rapid resolution of anterior uveitis within days while the epithelial defect fully healed within a month...
May 18, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28483289/an-observational-study-to-determine-whether-routinely-sending-patients-home-with-a-24-hour-supply-of-topical-tetracaine-from-the-emergency-department-for-simple-corneal-abrasion-pain-is-potentially-safe
#10
Neil Waldman, Ben Winrow, Ian Densie, Andrew Gray, Scott McMaster, George Giddings, John Meanley
STUDY OBJECTIVE: To determine if the number of emergency department (ED) rechecks, persistent fluorescein uptake, ophthalmology referrals, or complications would be affected by the prescription of topical tetracaine for pain relief from simple corneal abrasions (SCAs). METHODS: This retrospective cohort study was conducted in an ED where policy change allowed physicians to use topical tetracaine hydrochloride 1% eye drops for 24 hours for pain treatment for patients with corneal abrasions...
May 2, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28476660/%C3%AE-adrenergic-induced-sr-ca-2-leak-is-mediated-by-an-epac-nos-pathway
#11
Laëtitia Pereira, Dan J Bare, Samuel Galice, Thomas R Shannon, Donald M Bers
Cardiac β-adrenergic receptors (β-AR) and Ca(2+)-Calmodulin dependent protein kinase (CaMKII) regulate both physiological and pathophysiological Ca(2+) signaling. Elevated diastolic Ca(2+) leak from the sarcoplasmic reticulum (SR) contributes to contractile dysfunction in heart failure and to arrhythmogenesis. β-AR activation is known to increase SR Ca(2+) leak via CaMKII-dependent phosphorylation of the ryanodine receptor. Two independent and reportedly parallel pathways have been implicated in this β-AR-CaMKII cascade, one involving exchange protein directly activated by cAMP (Epac2) and another involving nitric oxide synthase 1 (NOS1)...
July 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28458772/comparative-study-of-compounded-anesthetic-benzocaine-lidocaine-tetracaine-blt-cream-with-and-without-abrasive-particles
#12
Metavee Boonsiri, Deanna Diaz, Theerayuth Sukmee, Joyce Okawa, Chérie M Ditre
Objective: The purpose of this study was to compare the use of benzocaine, lidocaine, tetracaine (BLT) cream with and without abrasive particles to see which type of cream is more effective in reducing discomfort during cosmetic dermatologic procedures, specifically procedures using hyaluronic acid (HA) injectables. Methods: The study was conducted as a single-site, double-blind, paired study. Participants: Thirty-one subjects were enrolled. Men and women over 18, but not more than 75 years of age, were included...
April 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28372769/the-power-of-lidocaine-epinephrine-and-tetracaine-let-and-a-child-life-specialist-when-suturing-lacerations-in-children
#13
Heather A Martin
No abstract text is available yet for this article.
March 2017: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/28253176/intranasal-tetracaine-and-oxymetazoline-spray-for-maxillary-local-anesthesia-without-injections
#14
Mana Saraghi, Elliot V Hersh
No abstract text is available yet for this article.
March 2017: General Dentistry
https://www.readbyqxmd.com/read/28230244/topical-anaesthetics-for-pain-control-during-repair-of-dermal-laceration
#15
REVIEW
Baraa O Tayeb, Anthony Eidelman, Cristy L Eidelman, Ewan D McNicol, Daniel B Carr
BACKGROUND: Topical local anaesthetics provide effective analgesia for patients undergoing numerous superficial procedures, including repair of dermal lacerations. The need for cocaine in topical anaesthetic formulations has been questioned because of concern about adverse effects, thus novel preparations of cocaine-free anaesthetics have been developed. This review was originally published in 2011 and has been updated in 2017. OBJECTIVES: To assess whether benefits of non-invasive topical anaesthetic application occur at the expense of decreased analgesic efficacy...
February 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28182013/duodenal-glp-1-signaling-regulates-hepatic-glucose-production-through-a-pkc-%C3%AE-dependent-neurocircuitry
#16
Mengliu Yang, Jinzhi Wang, Shaobo Wu, Lei Yuan, Xiaodong Zhao, Chaohong Liu, Jing Xie, Yanjun Jia, Yerui Lai, Allan Zijian Zhao, Guenther Boden, Ling Li, Gangyi Yang
Intestinal glucagon-like peptide-1 (GLP-1) is a hormone that stimulates insulin secretion and acts as a neuropeptide to control glucose homeostasis, but little is known whether intestinal GLP-1 has any effect in the control of hepatic glucose production (HGP). Here we found that intraduodenal infusion of GLP-1 activated duodenal PKC-δ, lowered HGP and was accompanied by a decrease in hepatic expression of gluconeogenic enzymes and an increase in hepatic insulin signaling in rats. However, gut co-infusion of either the GLP-1 receptor antagonist Ex-9, or the PKC-δ inhibitor rottlerin with GLP-1, negated the ability of gut GLP-1 to lower HGP and to increase hepatic insulin signaling during clamps...
February 9, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28130888/first-time-success-with-needle-procedures-was-higher-with-a-warm-lidocaine-and-tetracaine-patch-than-an-eutectic-mixture-of-lidocaine-and-prilocaine-cream
#17
Giorgio Cozzi, Fabio Borrometi, Franca Benini, Elena Neri, Francesca Rusalen, Loredana Celentano, Davide Zanon, Silvana Schreiber, Luca Ronfani, Egidio Barbi
AIM: More than 50% of children report apian during venepuncture or intravenous cannulation and using local anaesthetics before needle procedures can lead to different success rates. This study examined how many needle procedures were successful at the first attempt when children received either a warm lidocaine and tetracaine patch or an eutectic mixture of lidocaine and prilocaine (EMLA) cream. METHODS: We conducted this multicentre randomised controlled trial at three tertiary-level children's hospitals in Italy in 2015...
January 27, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28060026/exponential-decay-metrics-of-topical-tetracaine-hydrochloride-administration-describe-corneal-anesthesia-properties-mechanistically
#18
Jason Ethington, David Goldmeier, Bruce I Gaynes
PURPOSE: To identify pharmacodynamic (PD) and pharmacokinetic (PK) metrics that aid in mechanistic understanding of dosage considerations for prolonged corneal anesthesia. METHODS: A rabbit model using 0.5% tetracaine hydrochloride was used to induce corneal anesthesia in conjunction with Cochet-Bonnet anesthesiometry. Metrics were derived describing PD-PK parameters of the time-dependent domain of recovery in corneal sensitivity. Curve fitting used a 1-phase exponential dissociation paradigm assuming a 1-compartment PK model...
March 2017: Cornea
https://www.readbyqxmd.com/read/28046151/pain-alleviation-during-castration-of-piglets-a-comparative-study-of-different-farm-options
#19
COMPARATIVE STUDY
F Gottardo, A Scollo, B Contiero, A Ravagnani, G Tavella, D Bernardini, G M De Benedictis, S A Edwards
Pain alleviation associated with castration of piglets is an important welfare issue. The present study compares the effect of different approaches and products suitable for farmer use, with the aim to alleviate pain due to castration in piglets. A randomized within-litter design, with 28 replicate litters, compared 7 treatments: handling () restraint of the piglet and manipulation of the scrotum, castration without pain relief (), 2 treatments (, ) with different concentrations of tetracaine (2 and 6%) applied topically 10 min before and immediately post-surgery, and 3 treatments with i...
December 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/28017670/presynaptic-facilitation-by-tetracaine-of-glutamatergic-spontaneous-excitatory-transmission-in-the-rat-spinal-substantia-gelatinosa-involvement-of-trpa1-channels
#20
Lian-Hua Piao, Tsugumi Fujita, Ting Yu, Eiichi Kumamoto
The amide-type local anesthetic (LA) lidocaine activates transient receptor potential (TRP) ankyrin-1 (TRPA1) channels to facilitate spontaneous l-glutamate release onto spinal substantia gelatinosa (SG) neurons, which play a crucial role in regulating nociceptive transmission. In contrast, the ester-type LA procaine reduces the spontaneous release of l-glutamate in SG neurons. In order to determine whether TRPA1 activation by LAs is specific to amide-types, we examined the actions of tetracaine, another ester-type LA, and other amide-type LAs on glutamatergic spontaneous excitatory transmission in SG neurons by focusing on TRP activation...
February 15, 2017: Brain Research
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