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Tolerance Reduction

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https://www.readbyqxmd.com/read/28441031/lead-accumulation-and-distribution-in-maize-seedlings-relevance-to-biomass-sproduction-and-metal-phytoextraction
#1
Dmitry I Bashmakov, Alina N Kluchagina, Przemysław Malec, Kazimierz Strzałka, Alexander S Lukatkin
Among trace metals, lead is a highly toxic contaminant, being hazardous to humans and animals. Application of maize plants for phytoremediation of polluted soils and waters has recently been of particular interest. The aim of this work is to investigate the Pb-phytoextraction potential of the maize cv. Tzariza used widely in Eastern European agriculture. Maize seedlings were exposed in a nutrient solution to 0.1 - 10000 µM of Pb2+ for 21 days. Lead accumulated mostly in conductive tissues and shoots at 0...
April 25, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28440014/biomass-derived-n-doped-porous-carbon-supported-single-fe-atoms-as-superior-electrocatalysts-for-oxygen-reduction
#2
Zhengping Zhang, Xinjin Gao, Meiling Dou, Jing Ji, Feng Wang
Exploring sustainable and high-performance electrocatalysts for the oxygen reduction reaction (ORR) is the crucial issue for the large-scale application of fuel cell technology. A new strategy is demonstrated to utilize the biomass resource for the synthesis of N-doped hierarchically porous carbon supported single-atomic Fe (SA-Fe/NHPC) electrocatalyst toward the ORR. Based on the confinement effect of porous carbon and high-coordination natural iron source, SA-Fe/NHPC, derived from the hemin-adsorbed bio-porphyra-carbon by rapid heat-treatment up to 800 °C, presents the atomic dispersion of Fe atoms in the N-doped porous carbon...
April 25, 2017: Small
https://www.readbyqxmd.com/read/28440009/sodium-glucose-co-transporter-2-inhibitors-for-type-2-diabetes-mellitus-an-overview-for-the-primary-care-physician
#3
REVIEW
Paresh Dandona, Ajay Chaudhuri
AIMS: Sodium-glucose co-transporter type 2 (SGLT2) inhibitors are a new class of anti-hyperglycaemic agents in type 2 diabetes mellitus (T2DM). This review examines their mechanism of action and provides an overview of safety and efficacy from the main studies of SGLT2 inhibitors marketed in the United States and Europe, namely, canagliflozin, dapagliflozin and empagliflozin. METHODS: We searched the PubMed database to identify relevant publications on the mechanism of action of SGLT2 inhibitors and clinical trial reports...
April 24, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28439987/comparison-of-silodosin-versus-tadalafil-in-patients-with-lower-urinary-tract-symptoms-associated-with-benign-prostatic-hyperplasia
#4
Masaki Yoshida, Hideki Origasa, Narihito Seki
OBJECTIVES: To compare the efficacy and safety of silodosin versus tadalafil for treating lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH). METHODS: After informed consent, patients with LUTS/BPH were randomized in a 1:1 ratio to receive silodosin 8 mg/day or tadalafil 5 mg/day for 8 weeks (Period 1). Patients treated with tadalafil entered an exploratory phase and received silodosin or tadalafil for another 8 weeks. The primary efficacy endpoint was the change in the total International Prostate Symptom Score (IPSS) with Period 1 treatment...
April 25, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28439881/effect-of-cocoa-on-blood-pressure
#5
REVIEW
Karin Ried, Peter Fakler, Nigel P Stocks
BACKGROUND: High blood pressure is an important risk factor for cardiovascular disease, contributing to about 50% of cardiovascular events worldwide and 37% of cardiovascular-related deaths in Western populations. Epidemiological studies suggest that cocoa-rich products reduce the risk of cardiovascular disease. Flavanols found in cocoa have been shown to increase the formation of endothelial nitric oxide which promotes vasodilation and therefore blood pressure reduction. Here we update previous meta-analyses on the effect of cocoa on blood pressure...
April 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28439669/effects-of-desiccation-and-starvation-on-thermal-tolerance-and-the-heat-shock-response-in-forest-ants
#6
Andrew D Nguyen, Kerri DeNovellis, Skyler Resendez, Jeremy D Pustilnik, Nicholas J Gotelli, Joel D Parker, Sara Helms Cahan
Temperature increases associated with global climate change are likely to be accompanied by additional environmental stressors such as desiccation and food limitation, which may alter how temperature impacts organismal performance. To investigate how interactions between stressors influence thermal tolerance in the common forest ant, Aphaenogaster picea, we compared the thermal resistance of workers to heat shock with and without pre-exposure to desiccation or starvation stress. Knockdown (KD) time at 40.5 °C of desiccated ants was reduced 6% compared to controls, although longer exposure to desiccation did not further reduce thermal tolerance...
April 24, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28439024/nip1-2-is-a-plasma-membrane-localized-transporter-mediating-aluminum-uptake-translocation-and-tolerance-in-arabidopsis
#7
Yuqi Wang, Ruihong Li, Demou Li, Xiaomin Jia, Dangwei Zhou, Jianyong Li, Sangbom M Lyi, Siyu Hou, Yulan Huang, Leon V Kochian, Jiping Liu
Members of the aquaporin (AQP) family have been suggested to transport aluminum (Al) in plants; however, the Al form transported by AQPs and the roles of AQPs in Al tolerance remain elusive. Here we report that NIP1;2, a plasma membrane-localized member of the Arabidopsis nodulin 26-like intrinsic protein (NIP) subfamily of the AQP family, facilitates Al-malate transport from the root cell wall into the root symplasm, with subsequent Al xylem loading and root-to-shoot translocation, which are critical steps in an internal Al tolerance mechanism in Arabidopsis We found that NIP1;2 transcripts are expressed mainly in the root tips, and that this expression is enhanced by Al but not by other metal stresses...
April 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28438927/the-role-of-psl-genes-in-antibiotic-tolerance-of-adherent-pseudomonas-aeruginosa
#8
Keiji Murakami, Tsuneko Ono, Darija Viducic, Yoko Somiya, Reiko Kariyama, Kenji Hori, Takashi Amoh, Katsuhiko Hirota, Hiromi Kumon, Matthew R Parsek, Yoichiro Miyake
Bacteria attached to a surface are generally more tolerant to antibiotics than their planktonic counterparts, even without the formation of a biofilm. The mechanism of antibiotic tolerance in biofilm communities is multifactorial, and the genetic backgound underlying this antibiotic tolerance has not yet been fully elucidated. Using transposon mutagenesis, we isolated a mutant with reduced tolerance to biapenem (relative to the wild-type) from adherent cells. Sequencing analysis revealed a mutation in the pslL gene, which is a part of the polysaccharide biosynthesis operon...
April 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28438879/definitive-intensity-modulated-radiation-therapy-in-elderly-patients-with-locally-advanced-oropharyngeal-cancer
#9
Francesca DE Felice, Alessandro Galdieri, Gessica Abate, Nadia Bulzonetti, Daniela Musio, Vincenzo Tombolini
BACKGROUND: To evaluate the treatment tolerance and clinical outcomes in patients aged 70 years and older with locally advanced oropharyngeal cancer treated by definitive intensity-modulated radiation therapy (IMRT). PATIENTS AND METHODS: We retrospectively analyzed 15 consecutive elderly patients, with histologically-proven squamous cell carcinoma of the oropharynx, staged T3-4 with or without involved lymph nodes at diagnosis, who received definitive sequential IMRT (70 Gy; 2 Gy/fraction)...
May 2017: In Vivo
https://www.readbyqxmd.com/read/28437989/low-loss-compact-and-fabrication-tolerant-si-wire-90%C3%A2-waveguide-bend-using-clothoid-and-normal-curves-for-large-scale-photonic-integrated-circuits
#10
Takeshi Fujisawa, Shuntaro Makino, Takanori Sato, Kunimasa Saitoh
Ultimately low-loss 90° waveguide bend composed of clothoid and normal curves is proposed for dense optical interconnect photonic integrated circuits. By using clothoid curves at the input and output of 90° waveguide bend, straight and bent waveguides are smoothly connected without increasing the footprint. We found that there is an optimum ratio of clothoid curves in the bend and the bending loss can be significantly reduced compared with normal bend. 90% reduction of the bending loss for the bending radius of 4 μm is experimentally demonstrated with excellent agreement between theory and experiment...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437557/expression-of-catalase-alcohol-dehydrogenase-and-malate-dehydrogenase-in-rot-grains-upon-fungicide-use-on-maize-hybrids-grown-at-different-spacings
#11
E R Kluge, M C Mendes, M V Faria, H O Santos, L A Santos, I E Sandini
In this study, we evaluated the fungicide effect on the incidence of rot grains and expression of catalase (CAT), alcohol dehydrogenase (ADH), and malate dehydrogenase (MDH) enzymes in commercial maize hybrids grown with conventional and reduced spacing in Guarapuava, PR, Brazil. The experiment was designed in random blocks with a 3 × 8-factorial scheme, totaling 24 treatments. The first factor constituted three levels, the first with foliar fungicide application [150.0 g/L trifloxystrobin (15.0%, w/v) + 175...
April 20, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28437278/pharmacodynamic-and-kinetic-behavior-of-low-intermediate-and-high-dose-landiolol-during-long-term-infusion-in-caucasians
#12
Günther Krumpl, Ivan Ulč, Michaela Trebs, Pavla Kadlecová, Juri Hodisch, Gabriele Maurer, Bernhard Husch
PK, PD, safety, and tolerability of long-term administration of landiolol, a fast-acting cardioselective β-blocker, were investigated for the first time in Caucasian subjects in a prospective clinical trial.Blood concentrations of landiolol and its metabolites, HR, BP and ECG parameters were studied in twelve healthy volunteers receiving continuous infusions of a new 12 mg/mL formulation of landiolol using a dose-escalation regimen (10 µg/kg BW/min for 2 hr, 20 µg/kg BW/min for 2 hr, 40 µg/kg BW/min for 20 hr, 6 hr follow-up)...
April 18, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28437200/effects-of-dietary-macronutrient-composition-on-fndc5-and-irisin-in-mice-skeletal-muscle
#13
Simone Moreira de Macêdo, Deborah de Farias Lelis, Keila Lopes Mendes, Carlos Alberto de Carvalho Fraga, Igor V Brandi, Jonh David Feltenberger, Lucyana Conceição Farias, André Luiz Sena Guimarães, Alfredo Maurício Batista de Paula, Sérgio Henrique de Sousa Santos
BACKGROUND: Fibronectin type III domain containing 5 (FNDC5) and its protein product Irisin are therapeutic targets for obesity-associated disorders. Irisin plays an important role in energy regulation, inducing browning of white adipocytes, and improving obesity. We aimed to investigate the association between muscle Irisin expression and dietary quality. METHODS: Twenty-eight female mice were divided into four groups and fed the following experimental diets for 60 days: standard diet (SD), high-carbohydrate diet (HCD), high-fat diet (HFD), and high-protein diet (HPD)...
February 23, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28436739/prediabetes-exhibits-decreased-disposition-index-correlated-with-deterioration-of-glycemic-parameters-in-nonobese-japanese-subjects-a-cross-sectional-study-from-medical-examination
#14
Yasutaka Takeda, Yukihiro Fujita, Tsuyoshi Yanagimachi, Jun Honjo, Atsuko Abiko, Mahito Asai, Masakazu Haneda
BACKGROUND: Prediabetes, defined as impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), likely develops to type 2 diabetes mellitus (DM) and independently increases cardiovascular risk. We employed disposition index (DI), a new metabolic parameter indicating the pancreatic beta cell function adjusted for insulin resistance, and investigated whether it could be altered in Japanese population with prediabetes and associated with early glucose intolerance. METHODS: A total of 102 adults who underwent an oral glucose tolerance test at the medical screening were designated to normal glucose tolerance (NGT), IFG, IGT, and DM...
April 24, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28436223/interconnected-hierarchically-porous-fe-n-codoped-carbon-nanofibers-as-efficient-oxygen-reduction-catalysts-for-zn-air-batteries
#15
Yingxuan Zhao, Qingxue Lai, Ya Wang, Junjie Zhu, Yan Yu Liang
Developing porous carbon-based no-precious metal catalysts towards oxygen reduction reaction (ORR) is a suitable approach to significantly reduce the costs of fuel cells or metal-air batteries. Herein, interconnected hierarchically porous carbon nanofibers simultaneously doped with nitrogen and iron (HP-Fe-N/CNFs) were fabricated by facile pyrolysis of polypyrrole coated electrospun polystyrene/FeCl3 fibers. The obtained carbon nanofibers present high specific surface area (569.6 m2 g-1) and large pore volume (1...
April 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28435305/glucagon-like-peptide-1-receptor-agonists-a-systematic-review-of-comparative-effectiveness-research
#16
REVIEW
Philip A Levin, Hiep Nguyen, Eric T Wittbrodt, Seoyoung C Kim
BACKGROUND: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) act by increasing insulin secretion, decreasing glucagon secretion, slowing gastric emptying, and increasing satiety. OBJECTIVE: Published evidence directly comparing GLP-1RAs with other approved treatments for type 2 diabetes (T2D) was systematically reviewed. METHODS: A literature search was performed using MEDLINE and Embase databases to identify papers comparing GLP-1RAs with other classes of glucose-lowering therapy in patients with T2D...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/28435213/comparison-of-0-2-and-0-18-hyaluronate-eye-drops-in-patients-with-moderate-to-severe-dry-eye-with-keratitis-or-keratoconjunctivitis
#17
Dorothea Groß, Marc Childs, Jean-Marie Piaton
PURPOSE: Comparison of efficacy and safety of 0.2% and 0.18% hyaluronic acid (HA) eye drops three times a day (tid) in patients with moderate to severe dry eye disease, related to keratitis or keratoconjunctivitis. PATIENTS AND METHODS: Prospective, multicenter, randomized, single-masked, phase IIIb, noninferiority study (0.2% HA vs 0.18% HA) in two parallel groups over a period of 84 days. N=70 patients were evaluated. Primary efficacy outcome was ocular surface (OS) staining change on day 35 (D35), compared to baseline...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28434203/topiramate-monotherapy-for-juvenile-myoclonic-epilepsy
#18
REVIEW
Jia Liu, Lu-Ning Wang, Yu-Ping Wang
BACKGROUND: Topiramate is a newer broad-spectrum antiepileptic drug (AED). Some studies have shown the benefits of topiramate monotherapy in the treatment of juvenile myoclonic epilepsy (JME). However, there are no current systematic reviews to determine the efficacy and tolerability of topiramate monotherapy in people with JME. This is an updated version of the original Cochrane Review published in Issue 12, 2015. OBJECTIVES: To evaluate the efficacy and tolerability of topiramate monotherapy in the treatment of JME...
April 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28434175/myoxinol-ointment-for-the-treatment-of-acute-fissure
#19
J Martellucci, G Rossi, I Corsale, P Carrieri, M D'Elia, I Giani
Myoxinol is a complex of oligopeptides obtained from the seeds of Hibiscus esculentus used in cosmetic as natural alternative to botulin toxin. The aim of the study was to evaluate the safety and effectiveness of local myoxinol for the treatment of acute anal fissure. All the consecutive patients with acute fissure treated from January to June 2014 underwent 30 days of topical treatment (twice/day) with a mioxinol based ointment. Pain, symptomatic relief, fissure healing and re-epithelization, 1-year recurrence rate, subjective satisfaction and need for further treatments were evaluated...
April 22, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28433829/successful-repeat-sacroplasty-in-a-patient-with-a-recurrent-sacral-insufficiency-fracture-a-case-report
#20
Jeremy I Simon, David B Surrey, Paul Kitei, Matthew Sonagere, Jeffrey Gehret, David Smoger
The standard of care for treatment of sacral insufficiency fractures (SIF) remains conservative management with limited weight-bearing and analgesics, as most fractures heal within 12 weeks. For those who fail conservative therapy, are immobile or cannot tolerate the pain despite analgesic therapy, as well as those who do not improve with time, rest, or activity modification, minimally invasive surgery with percutaneous transverse screw fixation across the fracture is effective. However, a less invasive procedure, percutaneous sacroplasty, may be an option for potential rapid pain reduction...
April 19, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
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