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Diabetic macular edema

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https://www.readbyqxmd.com/read/28076563/influence-of-the-epiretinal-membrane-on-ranibizumab-therapy-outcomes-in-patients-with-diabetic-macular-edema
#1
Nimet Yesim Ercalik, Serhat Imamoglu, Esra Turkseven Kumral, Nursal Melda Yenerel, Handan Bardak, Yavuz Bardak
Purpose: To investigate the influence of the epiretinal membrane (ERM) on intravitreal ranibizumab (IVR) therapy for diabetic macular edema (DME). Methods: This retrospective study included 56 eyes of 48 patients with DME divided into two groups: the DME with ERM (study) and only DME (control) groups. Changes in the central macular thickness (CMT) and best-corrected visual acuity (BCVA) were evaluated. Results: In the study group, although the CMT was significantly reduced following the first injection (p<0...
November 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28073426/the-prevention-and-treatment-of-retinal-complications-in-diabetes
#2
Susanne Gabriele Schorr, Hans-Peter Hammes, Ulrich Alfons Müller, Heinz-Harald Abholz, Rüdiger Landgraf, Bernd Bertram
BACKGROUND: Microvascular complications of diabetes mellitus can cause retino pathy and maculopathy, which can irreversibly damage vision and lead to blindness. The prevalence of retinopathy is 9-16% in patients with type 2 diabetes and 24-27% in patients with type 1 diabetes. 0.2-0.5% of diabetics are blind. METHODS: The National Disease Management Guideline on the prevention and treatment of retinal complications in diabetes was updated according to recommendations developed by seven scientific medical societies and organizations and by patient representatives and then approved in a formal consensus process...
December 2, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28068435/adaptive-optics-reveals-photoreceptor-abnormalities-in-diabetic-macular-ischemia
#3
Peter L Nesper, Fabio Scarinci, Amani A Fawzi
Diabetic macular ischemia (DMI) is a phenotype of diabetic retinopathy (DR) associated with chronic hypoxia of retinal tissue. The goal of this prospective observational study was to report evidence of photoreceptor abnormalities using adaptive optics scanning laser ophthalmoscopy (AOSLO) in eyes with DR in the setting of deep capillary plexus (DCP) non-perfusion. Eleven eyes from 11 patients (6 women, age 31-68), diagnosed with DR without macular edema, underwent optical coherence tomography angiography (OCTA) and AOSLO imaging...
2017: PloS One
https://www.readbyqxmd.com/read/28063765/skin-autofluorescence-renal-insufficiency-and-retinopathy-in-patients-with-type-2-diabetes
#4
Rabia Bentata, Audrey Cougnard-Grégoire, Marie Noëlle Delyfer, Cécile Delcourt, Laurence Blanco, Emilie Pupier, Marie Bénédicte Rougier, Kalina Rajaobelina, Marie Hugo, Jean François Korobelnik, Vincent Rigalleau
OBJECTIVES: Advanced glycation end-products (AGEs) are involved in diabetic retinopathy (DR). Their accumulation in tissues can be analyzed by measuring the skin autofluorescence (sAF). We hypothesized that renal insufficiency, another cause of high sAF, may disturb the relation between sAF and DR. RESEARCH DESIGN AND METHODS: We measured sAF with an AGE-Reader in 444 patients with type 2 diabetes (T2D), and we analyzed their retinal status. The associations of sAF with DR, and interaction with renal insufficiency were estimated by multivariate logistic regression analysis...
October 30, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28061854/association-of-statin-use-and-hypertriglyceridemia-with-diabetic-macular-edema-in-patients-with-type-2-diabetes-and-diabetic-retinopathy
#5
Yoo-Ri Chung, Sung Wook Park, Shin-Young Choi, Seung Woo Kim, Ka Young Moon, Jeong Hun Kim, Kihwang Lee
BACKGROUND: To investigate the effects of dyslipidemia and statin therapy on progression of diabetic retinopathy and diabetic macular edema in patients with type 2 diabetes. METHODS: The medical records of 110 patients with type 2 diabetes (70 statin users and 40 non-users) were retrospectively reviewed. The two outcome measures were progression of diabetic retinopathy by two or more steps on the early treatment diabetic retinopathy study scale and diabetic macular edema based on optical coherence tomography...
January 7, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28060586/evidence-based-treatment-of-diabetic-macular-edema
#6
Rasha Barham, Hala El Rami, Jennifer K Sun, Paolo S Silva
Diabetes mellitus is a chronic disease that affects 415 million people worldwide. Despite treatment advances, diabetic eye disease remains a leading cause of vision loss worldwide. Diabetic macular edema (DME) is a common cause of vision loss in diabetic patients. The pathophysiology is complex and involves multiple pathways that ultimately lead to central retinal thickening and, if untreated, visual loss. First-line treatment of DME has evolved from focal/grid laser established by the Early Treatment of Diabetic Retinopathy Study (ETDRS) to intravitreous pharmacologic therapy...
2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28018716/machine-learning-based-detection-of-age-related-macular-degeneration-amd-and-diabetic-macular-edema-dme-from-optical-coherence-tomography-oct-images
#7
Yu Wang, Yaonan Zhang, Zhaomin Yao, Ruixue Zhao, Fengfeng Zhou
Non-lethal macular diseases greatly impact patients' life quality, and will cause vision loss at the late stages. Visual inspection of the optical coherence tomography (OCT) images by the experienced clinicians is the main diagnosis technique. We proposed a computer-aided diagnosis (CAD) model to discriminate age-related macular degeneration (AMD), diabetic macular edema (DME) and healthy macula. The linear configuration pattern (LCP) based features of the OCT images were screened by the Correlation-based Feature Subset (CFS) selection algorithm...
December 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/28017424/predictors-of-long-term-visual-outcome-in-intermediate-uveitis
#8
Rachael L Niederer, Lazha Sharief, Asaf Bar, Sue L Lightman, Oren Tomkins-Netzer
PURPOSE: To describe factors that predict visual loss and complications in intermediate uveitis. DESIGN: Cross-sectional study. PARTICIPANTS: Subjects with intermediate uveitis were identified from a database of 1254 uveitis patients seen in the clinic of a single consultant (S.L.L.) between 2011 and 2013. METHODS: Information was gathered from the clinical notes of all subjects examined in clinic. MAIN OUTCOME MEASURES: Best-corrected visual acuity (BCVA), moderate visual loss (MVL; ≤20/50), severe visual loss (SVL; ≤20/200)...
December 22, 2016: Ophthalmology
https://www.readbyqxmd.com/read/28009415/dexamethasone-intravitreal-implant-at-the-time-of-cataract-surgery-in-eyes-with-diabetic-macular-edema
#9
Giacomo A Panozzo, Elena Gusson, Giorgio Panozzo, Giulia Dalla Mura
PURPOSE: To determine the potential role of intraoperative dexamethasone intravitreal implant (DEX-I) in reducing diabetic macular edema (DME) worsening after phacoemulsification. METHODS: This was a prospective study on 19 eyes of 19 patients with type 2 diabetes mellitus with DME and cataract. Mean preoperative Early Treatment Diabetic Retinopathy Study visual acuity (VA) was 16.7 letters. Mean foveal thickness (FT) was 451 μm. The DME was naive in 11 eyes and refractory in 8 eyes...
December 16, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28009414/bromfenac-eyedrops-in-the-treatment-of-diabetic-macular-edema-a-pilot-study
#10
Antonio Pinna, Francesco Blasetti, Giuseppe D'Amico Ricci, Francesco Boscia
PURPOSE: To evaluate the efficacy and safety of topical bromfenac in patients with newly diagnosed diabetic macular edema (DME). METHODS: In this pilot study including 17 patients with monocular, newly diagnosed DME, diagnosis of DME was established by the detection of retinal thickening at or within 500 μm of the center of the macula on ophthalmoscopic examination, according to the Early Treatment Diabetic Retinopathy Study classification. Central macular thickness (CMT) was determined by optical coherence tomography...
November 16, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28006063/intravitreal-aflibercept-injection-in-eyes-with-substantial-vision-loss-after-laser-photocoagulation-for-diabetic-macular-edema-subanalysis-of-the-vista-and-vivid-randomized-clinical-trials
#11
Charles C Wykoff, Dennis M Marcus, Edoardo Midena, Jean-François Korobelnik, Namrata Saroj, Andrea Gibson, Robert Vitti, Alyson J Berliner, Zinaria Williams Liu, Oliver Zeitz, Carola Metzig, Thomas Schmelter, Jeffrey S Heier
Importance: Information on the effect of anti-vascular endothelial growth factor therapy in eyes with diabetic macular edema (DME) with vision loss after macular laser photocoagulation is clinically valuable. Objective: To evaluate visual and anatomic outcomes in a subgroup of macular laser photocoagulation treatment control (hereafter laser control) eyes with substantial vision loss receiving treatment with intravitreal aflibercept injection. Design, Setting, and Participants: This investigation was a post hoc analysis of a subgroup of laser control eyes in 2 phase 3 trials-VISTA (Study of Intravitreal Aflibercept Injection in Patients With Diabetic Macular Edema) and VIVID (Intravitreal Aflibercept Injection in Vision Impairment Due to DME)-in a multicenter setting...
December 22, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28006049/further-scrutiny-of-vision-outcomes-when-aflibercept-is-used-as-rescue-treatment-for-eyes-with-diabetic-macular-edema-treated-with-laser
#12
Maureen G Maguire
No abstract text is available yet for this article.
December 22, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28006042/evaluating-effects-of-switching-anti-vascular-endothelial-growth-factor-drugs-for-age-related-macular-degeneration-and-diabetic-macular-edema
#13
Frederick L Ferris, Maureen G Maguire, Adam R Glassman, Gui-Shuang Ying, Daniel F Martin
Importance: When a patient with neovascular age-related macular degeneration or diabetic macular edema does not respond to an initial anti-vascular endothelial growth factor agent, usually after several injections, ophthalmologists may switch to another anti-vascular endothelial growth factor agent. Authors of case series have suggested beneficial effects from switching. However, to our knowledge, there are no studies with an appropriate control group to evaluate how such patients would do without switching agents...
December 22, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28005668/correlation-between-cystoid-spaces-in-chronic-diabetic-macular-edema-and-capillary-nonperfusion-detected-by-optical-coherence-tomography-angiography
#14
Valérie Mané, Bénédicte Dupas, Alain Gaudric, Sophie Bonnin, Alexandre Pedinielli, Elodie Bousquet, Ali Erginay, Ramin Tadayoni, Aude Couturier
PURPOSE: To study the relationship between the location of cystoid spaces and retinal capillary nonperfusion areas in diabetic cystoid macular edema (DCME). METHODS: In this retrospective study, 24 eyes of 21 patients with chronic DCME were followed using optical coherence tomography angiography. The capillary density of the superficial capillary plexus and deep capillary plexus was measured using AngioAnalytics software in all DCME eyes and in 20 healthy controls...
December 2016: Retina
https://www.readbyqxmd.com/read/27994438/comorbidity-and-health-care-visit-burden-in-working-age-commercially-insured-patients-with-diabetic-macular-edema
#15
Szilárd Kiss, Hitesh S Chandwani, Ashley L Cole, Vaishali D Patel, Orsolya E Lunacsek, Pravin U Dugel
PURPOSE: To examine the comorbidity profile and update estimates of health care resource utilization for commercially insured, working-age adults with diabetic macular edema (DME) relative to a matched comparison group of diabetic adults without DME. Additional comparisons were made in the subgroup of pseudophakic patients. PATIENTS AND METHODS: A retrospective matched-cohort study of commercially insured diabetic adults aged 18-63 years was conducted using medical and outpatient pharmacy claims (July 1, 2008-June 30, 2013)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27994434/increased-serum-level-of-homocysteine-correlates-with-retinal-nerve-fiber-layer-thinning-in-diabetic-retinopathy
#16
Khushboo Srivastav, Sandeep Saxena, Abbas A Mahdi, Rajendra K Shukla, Carsten H Meyer, Levent Akduman, Vinay K Khanna
PURPOSE: To study the correlation between serum levels of vitamin B12, folic acid, and homocysteine and the severity of diabetic retinopathy and the correlation with retinal nerve fiber layer (RNFL) thinning on spectral domain optical coherence tomography (SD-OCT). METHODS: In a tertiary care center-based prospective cross-sectional study, 60 consecutive cases and 20 healthy controls in the age group of 40-65 years were included. The eyes of the cases were divided into three groups according to Early Treatment Diabetic Retinopathy Study (ETDRS) classification: diabetes mellitus without retinopathy (n = 20), non-proliferative diabetic retinopathy with macular edema (n = 20), and proliferative diabetic retinopathy with macular edema (n = 20)...
2016: Molecular Vision
https://www.readbyqxmd.com/read/27993483/lens-power-axial-length-to-corneal-radius-ratio-and-association-with-diabetic-retinopathy-in-the-adult-population-with%C3%A2-type-2-diabetes
#17
Jiangnan He, Xian Xu, Jianfeng Zhu, Bijun Zhu, Bo Zhang, Lina Lu, Xiangui He, Xuelin Bai, Xun Xu, Haidong Zou
PURPOSE: To calculate crystalline lens power and to determine the relationship between ocular biometry and diabetic retinopathy (DR) in an adult population with type 2 diabetes mellitus (T2DM). DESIGN: Cross-sectional, population-based study. PARTICIPANTS: Patients with T2DM from the Beixinjing community, Changning district, Shanghai. METHODS: Random clustering sampling was used to identify adults with T2DM in the Beixinjing community...
December 16, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27983657/fingolimod-associated-bilateral-cystoid-macular-edema-wait-and-see
#18
REVIEW
Refik Pul, Alma Osmanovic, Holger Schmalstieg, Amelie Pielen, Kaweh Pars, Philipp Schwenkenbecher, Kurt Wolfram Sühs, Özlem Yildiz, Benedikt Frank, Martin Stangel, Thomas Skripuletz
Fingolimod 0.5-mg once-daily is an approved therapy for patients with relapsing-remitting multiple sclerosis (MS). Several pivotal and real-world studies have demonstrated that fingolimod is associated with the development of macular edema (ME). Herein, we present a case of a diabetic MS patient who developed severe bilateral ME during fingolimod treatment. By means of this case study we provide a detailed review about fingolimod associated macular edema (FAME), its current incidence with or without diabetes mellitus, and previous therapy attempts and outcomes in MS patients...
December 14, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27978559/oct-leakage-a-new-method-to-identify-and-locate-abnormal-fluid-accumulation-in-diabetic-retinal-edema
#19
José Cunha-Vaz, Torcato Santos, Luísa Ribeiro, Dalila Alves, Inês Marques, Morton Goldberg
Purpose: To identify retinal extracellular fluid changes and their correlation with increased retinal thickness (RT) in eyes with subclinical and clinical macular edema in diabetes type 2. Methods: A cohort of 48 eyes from 48 type 2 diabetic patients with mild or moderate nonproliferative diabetic retinopathy (Early Treatment Diabetic Retinopathy Study levels 20/35) were classified as having normal RT (10), subclinical macular edema (30), or clinical macular edema (8)...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27973190/indirect-comparison-of-triamcinolone-acetonide-with-ranibizumab-and-aflibercept-for-the-treatment-of-diabetic-macular-edema
#20
S Park, Y R Choi, S Jeung, I Choi, D Suh
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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