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Naoko Iida, Fumiaki Yamao, Yasukazu Nakamura, Tetsushi Iida
In forward genetics, identification of mutations is a time-consuming and laborious process. Modern whole-genome sequencing, coupled with bioinformatics analysis, has enabled fast and cost-effective mutation identification. However, for many experimental researchers, bioinformatics analysis is still a difficult aspect of whole-genome sequencing. To address this issue, we developed a browser-accessible and easy-to-use bioinformatics tool called Mutation discovery (Mudi;, which enables 'one-click' identification of causative mutations from whole-genome sequence data...
June 2014: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
Marie Claire Van Hout, Tim Bingham
BACKGROUND: The online promotion of 'drug shopping' and user information networks is of increasing public health and law enforcement concern. An online drug marketplace called 'Silk Road' has been operating on the 'Deep Web' since February 2011 and was designed to revolutionise contemporary drug consumerism. METHODS: A single case study approach explored a 'Silk Road' user's motives for online drug purchasing, experiences of accessing and using the website, drug information sourcing, decision making and purchasing, outcomes and settings for use, and perspectives around security...
September 2013: International Journal on Drug Policy
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