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https://www.readbyqxmd.com/read/28723974/alginate-hydrogels-allow-for-bioactive-and-sustained-release-of-vegf-c-and-vegf-d-for-lymphangiogenic-therapeutic-applications
#1
Kevin T Campbell, Dustin J Hadley, David L Kukis, Eduardo A Silva
Lymphatic dysfunction is associated with the progression of many cardiovascular disorders due to their role in maintaining tissue fluid homeostasis. Promoting new lymphatic vessels (lymphangiogenesis) is a promising strategy to reverse these cardiovascular disorders via restoring lymphatic function. Vascular endothelial growth factor (VEGF) members VEGF-C and VEGF-D are both potent candidates for stimulating lymphangiogenesis, though maintaining spatial and temporal control of these factors represents a challenge to developing efficient therapeutic lymphangiogenic applications...
2017: PloS One
https://www.readbyqxmd.com/read/28723714/vent-incisions-to-facilitate-peripheral-unfolding-of-the-dmek-graft
#2
Christopher Liu, Alfonso Vasquez-Perez, Jordan Vassileff Chervenkoff, Venkata Avadhanam
PURPOSE: To present the results of 15 cases in which a modified technique of Descemet membrane endothelial keratoplasty (DMEK) with vent incisions was used to assist unfolding of tight peripheral inward folds. METHODS: This is a retrospective case series of 15 consecutive eyes that underwent a modified vent incision technique for DMEK. Six oblique, small-size (1 mm) vent incisions parallel to the limbus and 3.5 mm from the center were performed after descemetorhexis...
July 17, 2017: Cornea
https://www.readbyqxmd.com/read/28723149/cyclewise-operation-of-printed-mos2-transistor-biosensors-for-rapid-biomolecule-quantification-at-femtomolar-levels
#3
Byunghoon Ryu, Hongsuk Nam, Bo-Ram Oh, Yujing Song, Pengyu Chen, Younggeun Park, Wenjie Wan, Katsuo Kurabayashi, Xiaogan Liang
Field-effect transistors made from MoS2 and other emerging layered semiconductors have been demonstrated to be able to serve as ultrasensitive biosensors. However, such nanoelectronic sensors still suffer seriously from a series of challenges associated with the poor compatibility between electronic structures and liquid analytes. These challenges hinder the practical biosensing applications that demand rapid, low-noise, highly specific biomolecule quantification at femtomolar levels. To address such challenges, we study a cyclewise process for operating MoS2 transistor biosensors, in which a series of reagent fluids are delivered to the sensor in a time-sequenced manner and periodically set the sensor into four assay-cycle stages, including incubation, flushing, drying, and electrical measurement...
February 24, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28722695/cardiac-cycle-efficiency-and-dicrotic-pressure-variations-new-parameters-for-fluid-therapy-a-pilot-observational-study
#4
Antonio Messina, Salvatore M Romano, Eleonora Bonicolini, Davide Colombo, Gianmaria Cammarota, Marco Chiostri, Francesco Della Corte, Paolo Navalesi, Didier Payen, Stefano Romagnoli
BACKGROUND: During a fluid challenge, the changes in cardiac performance and peripheral circulatory tone are closely related to the position of the ventricle on the Frank-Starling curve. Some patients have a good haemodynamic response to a fluid challenge, others hardly any response. The early haemodynamic effects of a fluid challenge could predict the final response before the entire fluid volume has been administered. OBJECTIVE: To assess whether a multivariate logistic regression model, including pulse pressure variation (PPV), cardiac cycle efficiency (CCE), arterial elastance and the difference between the dicrotic pressure and both systolic and mean arterial pressure (SAP - Pdic and MAP - Pdic) can predict cardiac responsiveness early during a fluid challenge in comparison with the standard procedure described elsewhere...
June 19, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28722332/functionalized-acupuncture-needle-as-surface-enhanced-resonance-raman-spectroscopy-sensor-for-rapid-and-sensitive-detection-of-dopamine-in-serum-and-cerebrospinal-fluid
#5
Liangbao Yang, Pan Li, Binbin Zhou, Xiaomin Cao, Xianghu Tang, Ling Hu, Jinhuai Liu
It is challenging to develop a robust sensor for simple and rapid operation and sensitive detection of neurotransmitter in complex specimen. In the present work, the ferric-citrate-functionalized Au nanoparticles [Au NPs/CA-Fe(III)] is utilized to develop a facile sensor based on Surface-enhanced Resonance Raman spectroscopy (SERRS) for sensitive detection of dopamine (DA). The sensor is prepared by decorating acupuncture needle with Au NPs, which enables the sufficient SERS enhancement. CA-Fe(III) structure was highly sensitive and selective to DA with formation of CA-Fe(III)-DA resonant structure, indicating the advantages of capturing, carrying and separating DA molecules from complicated samples with simple operation...
July 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28722241/mineralized-state-of-the-avian-influenza-virus-in-the-environment
#6
Hangyu Zhou, Guangchuan Wang, Xiaoyu Wang, Zhiyong Song, Ruikang Tang
Although the circulation of avian influenza in humans is limited, they can be transmitted from Aves to humans, representing a great challenge. Herein, we suggest that influenza viruses from Aves might exist in a mineralized state due to the high calcium concentrations in the avian intestine. Using two typical influenza viruses as examples, we demonstrate these viruses can self-mineralize in simulated avian intestinal fluid, resulting in egg-like virus-mineral structured composites. The mineralized viruses are more robust, with enhanced infectivity and thermostability...
July 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28721683/mesenchymal-stem-progenitor-cells-derived-from-articular-cartilage-synovial-membrane-and-synovial-fluid-for-cartilage-regeneration-current-status-and-future-perspectives
#7
REVIEW
Yi-Zhou Huang, Hui-Qi Xie, Antonietta Silini, Ornella Parolini, Yi Zhang, Li Deng, Yong-Can Huang
Large articular cartilage defects remain an immense challenge in the field of regenerative medicine because of their poor intrinsic repair capacity. Currently, the available medical interventions can relieve clinical symptoms to some extent, but fail to repair the cartilaginous injuries with authentic hyaline cartilage. There has been a surge of interest in developing cell-based therapies, focused particularly on the use of mesenchymal stem/progenitor cells with or without scaffolds. Mesenchymal stem/progenitor cells are promising graft cells for tissue regeneration, but the most suitable source of cells for cartilage repair remains controversial...
July 18, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28719956/a-case-of-ectopic-peritoneal-paragonimiasis-mimicking-diverticulitis-or-abdominal-abscess
#8
Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Yong Sik Yoon, Kyung Won Kim, Jaeeun Cho, Jong-Yil Chai, Yong Pil Chong
Paragonimiasis is a parasitic disease caused by Paragnonimus species. The primary site of infection is the lung, and extrapulmonary involvement is also reported. When infected with Paragonimus westermani, which is the dominant species in Korea, the central nervous system is frequently involved along with the liver, intestine, peritoneal cavity, retroperitoneum, and abdominal wall. Ectopic paragonimiasis raises diagnostic challenge since it is uncommon and may be confused with malignancy or other inflammatory diseases...
June 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28718403/adam-metalloprotease-released-cancer-biomarkers
#9
REVIEW
Peter Herrlich, Andreas Herrlich
Identification of early cancer, detection of progression, and monitoring of therapeutic success remain urgent issues in clinical medicine, particularly given the increasing cancer incidence in our aging populations. New methodologies have provided enormous progress over the past decades by defining the genetic and proteomic composition of cancers, yielding putative cancer biomarkers detectable in blood or other body fluids less invasively and more cheaply than using currently available screening techniques that often involve biopsies or surgery...
July 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28718049/good-things-in-small-packages-an-innovative-delivery-approach-for-inhaled-insulin
#10
James B Fink, Lisa Molloy, John S Patton, Valdecir Castor Galindo-Filho, Jacqueline de Melo Barcelar, Luciana Alcoforado, Simone Cristina Soares Brandão, Armèle Dornelas de Andrade
PURPOSE: The design development of a small, hand held, battery operated, breath actuated inhaler as a drug/device platform for inhaled insulin posed a number of technical challenges. Our goal was to optimize lung deposition and distribution with aerosol generators producing 3-6 μm particle size distribution. METHODS: In silico modeling with computational fluid dynamics (CFD) and in vitro testing of device components were assessed using an Alberta idealized adult airway (Copley, UK) to optimize mouthpiece and aerosol path design for dose delivered distal to the trachea...
July 17, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28718036/paravertebral-blocks-reduce-narcotic-use-without-affecting-perfusion-in-patients-undergoing-autologous-breast-reconstruction
#11
Elizabeth B Odom, Nili Mehta, Rajiv P Parikh, Ryan Guffey, Terence M Myckatyn
BACKGROUND: Autologous breast reconstruction offers excellent long term outcomes after mastectomy. However, maintaining adequate postoperative analgesia remains challenging. Use of paravertebral blocks (PVBs) reduces postoperative narcotic use and length of stay, and enhanced recovery protocols with mixed analgesia methods are gaining popularity, but few studies have explored the intraoperative effects of these interventions. METHODS: Patients who underwent abdominally based autologous breast reconstruction between 2010 and 2016 were compiled into a retrospective database...
July 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28716046/blood-volume-monitored-regulation-of-ultrafiltration-to-decrease-the-dry-weight-in-fluid-overloaded-hemodialysis-patients-a-randomized-controlled-trial
#12
Marlies Antlanger, Peter Josten, Michael Kammer, Isabella Exner, Katharina Lorenz-Turnheim, Manfred Eigner, Gernot Paul, Renate Klauser-Braun, Gere Sunder-Plassmann, Marcus D Säemann, Manfred Hecking
BACKGROUND: Because chronic fluid volume overload is associated with higher mortality, we tested whether blood-volume monitored regulation of ultrafiltration and dialysate conductivity (UCR) and/or regulation of ultrafiltration and temperature (UTR) would facilitate dry weight reduction, in comparison to conventional dialysis (CONV). METHODS: We carried out a multicenter, 4-week, randomized controlled trial in hemodialysis patients ≥15% above normal extracellular fluid volume (ECV), per bioimpedance spectroscopy, who were randomized 1:1:1...
July 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28715329/phased-array-imaging-of-complex-geometry-composite-components
#13
Alex J Brath, Francesco Simonetti, Francesco Simonetti
Progress in computational fluid dynamics (CFD) and the availability of new composite materials are driving major advances in the design of aerospace engine components which now have highly complex geometries optimized to maximize system performance. However, shape complexity poses significant challenges to traditional non-destructive evaluation (NDE) methods whose sensitivity and selectivity rapidly decrease as surface curvature increases. Additionally, new aerospace materials typically exhibit an intricate microstructure that further complicates the inspection...
July 13, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28714408/biomaterials-and-supercritical-fluid-technologies-which-perspectives-to-fabricate-artificial-extracellular-matrix
#14
Della Porta Giovanna, E Reverchon, N Maffulli
The foundation of tissue engineering for either therapeutic or diagnostic applications is the ability to exploit living cells. Tissue engineering utilizes living cells as engineering materials implanted, seeded or bio-plotted into an artificial structure capable of supporting three-dimensional tissue formation. These structures, typically called scaffolds, are critical, both ex vivo and in vivo, to influence their own microenvironments. Scaffolds can serve the following purposes: allow cell attachment and migration, deliver and retain cells and biochemical factors, enable diffusion of vital cell nutrients or expressed products, exert certain mechanical and biological influences to modify the behaviour of the cell phase...
July 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28714050/superiority-of-the-sonication-method-against-conventional-periprosthetic-tissue-cultures-for-diagnosis-of-prosthetic-joint-infections
#15
Sofia Tani, Panagiotis Lepetsos, Antonios Stylianakis, John Vlamis, Konstantinos Birbas, Ioannis Kaklamanos
INTRODUCTION: Diagnosis of periprosthetic infections is challenging. The aim of this study was to compare the diagnostic accuracy of conventional periprosthetic tissue culture and culture of sonication fluid of the explanted prostheses. METHODS: We prospectively enrolled 114 patients undergoing revision hip or knee arthroplasty because of loosening of the prostheses, at our institution, between July 2012 and July 2016. Patients' medical history and demographic characteristics were recorded...
July 17, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28713213/secondary-motion-in-three-dimensional-branching-networks
#16
Abhijit Guha, Kaustav Pradhan
A major aim of the present work is to understand and thoroughly document the generation, the three-dimensional distribution, and the evolution of the secondary motion as the fluid progresses downstream through a branched network. Six generations (G0-G5) of branches (involving 63 straight portions and 31 bifurcation modules) are computed in one go; such computational challenges are rarely taken in the literature. More than 30 × 10(6) computational elements are employed for high precision of computed results and fine quality of the flow visualization diagrams...
June 2017: Physics of Fluids
https://www.readbyqxmd.com/read/28712799/diagnosing-periprosthetic-joint-infection-and-the-winner-is
#17
Alisina Shahi, Timothy L Tan, Michael M Kheir, Dean D Tan, Javad Parvizi
BACKGROUND: Diagnosis of periprosthetic joint infection (PJI) remains a challenge despite a wide variety of available diagnostic tests. The question that arises is which of these tests has a better performance for diagnosing PJI. Diagnostic odds ratio (DOR) has been described as the best indicator for test performance. METHODS: To compare the performance of the standard diagnostic tests, the DOR of serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), synovial fluid (SF) white blood cell (WBC) count, SF polymorphonuclear (PMN%), and leukocyte esterase (LE) were calculated...
June 10, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28711597/micrornas-and-extracellular-vesicles-in-cholangiopathies
#18
REVIEW
P Olaizola, P Y Lee-Law, A Arbelaiz, A Lapitz, M J Perugorria, L Bujanda, J M Banales
Cholangiopathies encompass a heterogeneous group of disorders affecting biliary epithelial cells (i.e. cholangiocytes). Early diagnosis, prognosis and treatment still remain clinically challenging for most of these diseases and are critical for adequate patient care. In the past decade, extensive research has emphasized microRNAs (miRs) as potential non-invasive biomarkers and tools to accurately identify, predict and treat cholangiopathies. MiRs can be released extracellularly conjugated with lipoproteins or encapsulated in extracellular vesicles (EVs)...
July 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28711588/a-framework-for-computational-fluid-dynamic-analyses-of-patient-specific-stented-coronary-arteries-from-optical-coherence-tomography-images
#19
Susanna Migliori, Claudio Chiastra, Marco Bologna, Eros Montin, Gabriele Dubini, Cristina Aurigemma, Roberto Fedele, Francesco Burzotta, Luca Mainardi, Francesco Migliavacca
The clinical challenge of percutaneous coronary interventions (PCI) is highly dependent on the recognition of the coronary anatomy of each individual. The classic imaging modality used for PCI is angiography, but advanced imaging techniques that are routinely performed during PCI, like optical coherence tomography (OCT), may provide detailed knowledge of the pre-intervention vessel anatomy as well as the post-procedural assessment of the specific stent-to-vessel interactions. Computational fluid dynamics (CFD) is an emerging investigational tool in the setting of optimization of PCI results...
July 12, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28711543/clival-defect-with-primary-csf-rhinorrhea-a-very-rare-presentation-with-challenging-management
#20
Sheikh Asad, Jens Peters-Willke, Warwick Brennan, Saima Asad
Primary spontaneous cerebrospinal fluid (CSF) rhinorrhea due to clival defect is an extremely rare presentation and only six cases have been reported in the literature so far(17). We present a unique case of a 64-year-old lady who presented with 2 years history of ongoing CSF rhinorrhea. She had similar episode at the age of 40 and suffered from meningitis. She had MRI, CT cisternogram as well as CT of brain and that showed clival defect with CSF leak into the sphenoid sinus. She underwent trans-sphenoidal repair of the clival defect with concurrent lumbar drain insertion for CSF drainage...
July 12, 2017: World Neurosurgery
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