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https://www.readbyqxmd.com/read/29744430/preparation-of-chitin-pla-laminated-composite-for-implantable-application
#1
Romana Nasrin, Shanta Biswas, Taslim Ur Rashid, Sanjida Afrin, Rumana Akhter Jahan, Papia Haque, Mohammed Mizanur Rahman
The present study explores the possibilities of using locally available inexpensive waste prawn shell derived chitin reinforced and bioabsorbable polylactic acid (PLA) laminated composites to develop new materials with excellent mechanical and thermal properties for implantable application such as in bone or dental implant. Chitin at different concentration (1-20% of PLA) reinforced PLA films (CTP) were fabricated by solvent casting process and laminated chitin-PLA composites (LCTP) were prepared by laminating PLA film (obtained by hot press method) with CTP also by hot press method at 160 °C...
December 2017: Bioactive Materials
https://www.readbyqxmd.com/read/29627909/technological-advances-in-stent-therapies-a-year-in-review
#2
REVIEW
Jad Raffoul, Ammar Nasir, Andrew J P Klein
Stent technology has rapidly evolved since the first stainless steel bare metal stents with substantial developments in scaffolding, polymer, drug choice, drug delivery, and elution mechanisms. Most recently, there has been the evolution of bioabsorbable vascular scaffolds, potentially eliminating the need for long-term foreign object retention. These rapid developments have led to an ever-expanding selection of new stents, making the choice of which to use in which patient challenging. Operators must balance potential short- and long-term clinical ramifications, namely stent thrombosis, in-stent restenosis, target lesion revascularization, and target lesion failure...
April 7, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29619983/acute-thrombogenicity-of-fluoropolymer-coated-versus-biodegradable-and-polymer-free-stents
#3
Sho Torii, Qi Cheng, Hiroyoshi Mori, Michael J Lipinski, Eduardo Acampado, Laura E L Perkins, Syed F Hossainy, Stephen D Pacetti, Frank D Kolodgie, Renu Virmani, Aloke V Finn
AIMS: Durable-fluoropolymer coated everolimus-eluting stents (FP-EES) have shown lower rates of stent thrombosis (ST) versus bare-metal stents (BMS) and 1st-generation bioabsorbable-polymer (BP) DES. However, the specific role of the FP in thromboresistance has not been explored. METHODS AND RESULTS: A total of 57 stents were assessed in 3 separate ex-vivo swine arterio-venous shunt-model experiments [1st-shunt-experiment, custom-made fluoropolymer-coated BMS (FP-only) vs...
April 3, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29613762/synthetic-nanofiber-reinforced-amniotic-membrane-via-interfacial-bonding
#4
Huanhuan Liu, Zhengbing Zhou, Hui Lin, Juan Wu, Brian Ginn, Ji Suk Choi, Xuesong Jiang, Liam Chung, Jennifer H Elisseeff, Samuel Yiu, Hai-Quan Mao
Severe damage to the ocular surface can result in limbal stem cell (LSC) deficiency, which contributes to loss of corneal clarity, potential vision loss, chronic pain, photophobia, and keratoplasty failure. Human amniotic membrane (AM) is the most effective substrate for LSC transplantation to treat patients with LSC deficiency. However, the widespread use of the AM in the clinic remains a challenge because of the high cost for preserving freshly prepared AM and the weak mechanical strength of lyophilized AM...
April 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29578542/a-tailorable-in-situ-light-activated-biodegradable-vascular-scaffold
#5
Mazen S Albaghdadi, Jian Yang, Jessica H Brown, Neel A Mansukhani, Guillermo A Ameer, Melina R Kibbe
Biodegradable vascular scaffolds (BVS) are novel treatments for obstructive atherosclerotic cardiovascular disease that have been developed to overcome the limitations of traditional metallic drug-eluting stents (DES). The mechanical properties of bioabsorbable polymers used for the production of novel BVS are a key consideration for the clinical translation of this emerging technology. Herein, we describe the engineering of an in situ light-activated vascular scaffold (ILVS) comprised of a biodegradable citric acid-based elastomeric polymer, referred to as methacrylated poly-diol citrate (mPDC), and a diazeniumdiolate chitosan nitric oxide donor (chitoNO)...
April 2017: Advanced materials technologies
https://www.readbyqxmd.com/read/29513378/incidence-and-predictors-of-target-lesion-failure-in-a-multiethnic-asian-population-receiving-the-synergy-coronary-stent-a-prospective-all-comers-registry
#6
Rajiv Ananthakrishna, William Kristanto, Li Liu, Siew-Pang Chan, Poay Huan Loh, Edgar L Tay, Koo Hui Chan, Mark Y Chan, Chi-Hang Lee, Adrian F Low, Huay Cheem Tan, Joshua P Loh
OBJECTIVES: To evaluate the target lesion failure (TLF) rate of the SYNERGY stent in all-comers, multiethnic Asian population. BACKGROUND: Currently, most drug eluting stents deliver anti-proliferative drugs from a durable polymer which is associated with a risk of late stent thrombosis. The novel everolimus-eluting, platinum chromium SYNERGY stent is coated with a bioabsorbable abluminal polymer that resolves within 4 months. METHODS: This was a prospective, single center registry of consecutive patients treated with the SYNERGY stent between December 2012 and April 2015...
March 7, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29344373/multianalysis-with-optical-coherence-tomography-and-vasomotion-in-everolimus-eluting-stents-and-everolimus-eluting-biovascular-scaffolds-the-moves-trial
#7
Diego A Arroyo, Sara Schukraft, Zacharenia Kallinikou, Jean-Christophe Stauffer, Gérard Baeriswyl, Jean-Jacques Goy, Mario Togni, Stéphane Cook, Serban Puricel
Aims: To compare endothelium-dependent vasomotor function and vascular healing 15 months after implantation of two new-generation drug-eluting stents and biovascular scaffolds (BVS). Methods and results: A total of 28 patients previously treated with a SYNERGY stent (bioabsorbable polymer everolimus-eluting stents (BP-EES)), a PROMUS stent (persistent polymer everolimus-eluting stents (PP-EES)) or an ABSORB (BVS) underwent control coronary angiography, 15 months after implantation, coupled with optical coherence tomography imaging and supine bicycle exercise...
2018: Open Heart
https://www.readbyqxmd.com/read/29338896/novel-bioabsorbable-polymer-and-polymer-free-metallic-drug-eluting-stents
#8
REVIEW
Jason Nogic, Liam M McCormick, Rohin Francis, Nitesh Nerlekar, Catherine Jaworski, Nick E J West, Adam J Brown
The introduction of drug-eluting stents (DES) significantly reduced angiographic restenosis and the clinical need for revascularization following percutaneous coronary intervention. However, concerns remain regarding the long-term safety and efficacy of DES. The use of durable polymers for drug elution that have limited biocompatibility is thought to contribute toward DES failure, by promoting an adverse local inflammatory response and vascular toxicity. Biodegradable polymer and polymer-free metallic stents represent two novel technological solutions to this challenging clinical problem...
May 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29279677/on-the-synthesis-and-characterization-of-%C3%AE-tricalcium-phosphate-scaffolds-coated-with-collagen-or-poly-d-l-lactic-acid-for-alveolar-bone-augmentation
#9
Isadora S Deschamps, Gabriel L Magrin, Ricardo S Magini, Márcio C Fredel, Cesar A M Benfatti, Júlio C M Souza
Objectives: After tooth loss, dimensional alterations on the alveolar bone ridge can occur that can negatively affect the placement of dental implants. The purpose of this study was to evaluate the synthesis, and mechanical properties of β-tricalcium phosphate (β-TCP) scaffolds coated with bioabsorbable polymers, namely, collagen and poly (D, L-lactic acid) (PDLLA). Materials and Methods: β-TCP powder was obtained by reactive milling and then characterized by X-ray diffraction and scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDS)...
October 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/29278354/long-term-clinical-outcomes-of-a-crystalline-sirolimus-eluting-coronary-stent-with-a-fully-bioabsorbable-polymer-coating-five-year-outcomes-from-the-dessolve-i-and-ii-trials
#10
William Wijns, Mathias Vrolix, Stefan Verheye, Danny Schoors, Ton Slagboom, Marcel Gosselink, Edouard Benit, David Kandzari, Dennis Donohoe, John A Ormiston
AIMS: The aim was to evaluate the five-year clinical results of a sirolimus-eluting stent (MiStent SES) with a bioabsorbable coating designed for sustained drug delivery during and after rapid polymer dissolution. METHODS AND RESULTS: The five-year results from the DESSOLVE I and II trials including major adverse cardiac events (MACE), target lesion failure (TLF), target vessel failure (TVF), and stent thrombosis (ST) at five-year follow-up are reported. In DESSOLVE I, 10...
December 26, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29230917/interfacial-nanoprecipitation-toward-stable-and-responsive-microbubbles-and-their-use-as-a-resuscitative-fluid
#11
Yifeng Peng, Raymond P Seekell, Alexis R Cole, Jemima R Lamothe, Andrew T Lock, Sarah van den Bosch, Xiaoqi Tang, John N Kheir, Brian D Polizzotti
A new approach has been developed to prepare stable microbubbles (MBs) by interfacial nanoprecipitation of bioabsorbable polymers at air/liquid interfaces. This facile method offers robust control over the morphology and chemophysical properties of MBs by simple chemical modifications. This approach is amenable to large-scale manufacturing, and is useful to develop functional MBs for advanced biomedical applications. To demonstrate this, a MB-based intravenous oxygen carrier was created that undergoes pH-triggered self-elimination...
January 26, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29226468/peptide-integrated-optics
#12
Amir Handelman, Nadezda Lapshina, Boris Apter, Gil Rosenman
Bio-nanophotonics is a wide field in which advanced optical materials, biomedicine, fundamental optics, and nanotechnology are combined and result in the development of biomedical optical chips. Silk fibers or synthetic bioabsorbable polymers are the main light-guiding components. In this work, an advanced concept of integrated bio-optics is proposed, which is based on bioinspired peptide optical materials exhibiting wide optical transparency, nonlinear and electrooptical properties, and effective passive and active waveguiding...
February 2018: Advanced Materials
https://www.readbyqxmd.com/read/29203070/a-sirolimus-eluting-bioabsorbable-polymer-coated-stent-mistent-versus-an-everolimus-eluting-durable-polymer-stent-xience-after-percutaneous-coronary-intervention-dessolve-iii-a-randomised-single-blind-multicentre-non-inferiority-phase-3-trial
#13
Robbert J de Winter, Yuki Katagiri, Taku Asano, Krzysztof P Milewski, Philipp Lurz, Pawel Buszman, Gillian A J Jessurun, Karel T Koch, Roland P T Troquay, Bas J B Hamer, Ton Oude Ophuis, Jochen Wöhrle, Rafał Wyderka, Guillaume Cayla, Sjoerd H Hofma, Sébastien Levesque, Aleksander Żurakowski, Dieter Fischer, Maciej Kośmider, Pascal Goube, E Karin Arkenbout, Michel Noutsias, Markus W Ferrari, Yoshinobu Onuma, William Wijns, Patrick W Serruys
BACKGROUND: MiStent is a drug-eluting stent with a fully absorbable polymer coating containing and embedding a microcrystalline form of sirolimus into the vessel wall. It was developed to overcome the limitation of current durable polymer drug-eluting stents eluting amorphous sirolimus. The clinical effect of MiStent sirolimus-eluting stent compared with a durable polymer drug-eluting stents has not been investigated in a large randomised trial in an all-comer population. METHODS: We did a randomised, single-blind, multicentre, phase 3 study (DESSOLVE III) at 20 hospitals in Germany, France, Netherlands, and Poland...
February 3, 2018: Lancet
https://www.readbyqxmd.com/read/29174243/evaluation-and-efficacy-of-long-length-pronova-xr-bioabsorbable-polymer-stent-in-the-treatment-of-long-coronary-lesions
#14
M S Hiremath
AIM: The study aims an observational registry of the long and extra-long length (>33mm) Pronova XR stents in patients with long coronary lesions (>30mm) in a prospective real world study. METHODS AND RESULTS: Current study was conducted at Ruby Hall Clinic Pune, between July 2012 and July 2013 including 30 patients who underwent PTCA using long and extra-long Pronova XR stents. Among the stents used, one stent - 33mm, 2 stents - 38mm, 5 stents - 43mm and 25 stents were of 48mm in length...
November 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/29148244/real-life-experience-with-bioresorbable-polymer-everolimus-eluting-stents-is-this-an-answer-in-search-of-a-question
#15
EDITORIAL
Youssef Rahban, Carey Kimmelstiel
Stent thrombosis and clinically driven restenosis are rare in the era of newer generation DES. The Synergy bioresorbable polymer DES appears to be comparable to other durable polymer and other bioabsorbable polymer DES in terms of safety and efficacy at 1-year post implantation. Further long-term study is needed to determine the specific role of the Synergy stent and other DES with bioabsorbable polymers.
November 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29145993/an-absorbable-hydrogel-spray-reduces-postoperative-mediastinal-adhesions-after-congenital-heart-surgery
#16
Nahidh Hasaniya, Anees Razzouk, Jennifer Newcombe, Dana Hassneiah, Jessica Heimes, Joshua Gysbers, Timothy Martens, Leonard Bailey
BACKGROUND: Adhesions encountered during reoperative cardiac surgery can prolong operative time and increase operative risk. The purpose of this clinical study was to investigate the antiadhesion property of a synthetic bioabsorbable polymer spray after cardiac reoperations in infants. METHODS: A prospective randomized double-blinded study was designed. Forty infants requiring staged cardiac operations were randomly allocated to a study group (n = 20) or a control group (n = 20)...
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29061548/acute-performance-of-a-novel-restorative-transcatheter-aortic-valve-preclinical-results
#17
Yosuke Miyazaki, Osama I I Soliman, Mohammad Abdelghani, Athanasios Katsikis, Christophe Naz, Susana Lopes, Boris Warnack, Martijn Cox, Yoshinobu Onuma, Patrick W Serruys
AIMS: The Xeltis aortic valve leaflets are made from a bioabsorbable supramolecular polymer that guides the tissue to restoring itself. It is mounted on a self-expanding nitinol frame that includes three feelers and a native leaflet clipping mechanism. We sought to investigate the acute valve performance in a preclinical setting. METHODS AND RESULTS: In 33 sheep, 26 mm Xeltis aortic valves were transapically implanted in a 23 mm native annulus. Aortography (analysable, n=28) and echocardiography (analysable, n=20) images were acquired immediately after implantation of the Xeltis aortic valve to assess the acute device performance...
December 8, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29026706/development-of-novel-drug-eluting-stents-for-acute-myocardial-infarction
#18
REVIEW
Doo Sun Sim, Myung Ho Jeong
Delayed arterial healing at culprit sites after drug-eluting stent (DES) placement for acute myocardial infarction (AMI) is associated with increased risk of late stent thrombosis. The Korea Acute Myocardial Infarction Registry was established in commemoration of the 50th anniversary of Korea Circulation Society. Between November 2005 and December 2016, more than 62,000 patients were registered from 50 primary percutaneous coronary intervention (PCI) centers in Korea. DES in AMI may be safe and effective, however, there is concern about increased stent thrombosis after DES implantation in AMI patients, requiring longer-term dual anti-platelet therapy to reduce the risk of late stent thrombosis...
September 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/28931346/subhepatic-mass-occurrence-after-using-oxidized-and-regenerated-cellulose-polymer-in-laparoscopic-cholecystectomy-a-case-series
#19
Erasmo Spaziani, Annalisa Di Filippo, Piero Francioni, Martina Spaziani, Alessandro De Cesare, Marcello Picchio
BACKGROUND: Oxidized regenerated cellulose (ORC) is a bioabsorbable surgical hemostatic. We present the first prospective case series of circumscribed mass occurrence after using ORC in laparoscopic cholecystectomy. METHODS: Tabotamp (Ethicon, Inc., Somerville, NJ) in the form of tightly woven knitted patches was used to achieve hemostasis in 83 patients submitted to LC. RESULTS: A subhepatic mass was detected in five patients and radiologic characteristics were described...
February 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28923786/final-five-year-clinical-outcomes-in-the-evolve-trial-a-randomized-evaluation-of-a-novel-bioabsorbable-polymer-coated-everolimus-eluting-stent
#20
Ian T Meredith, Stefan Verheye, Christophe Dubois, Joseph Dens, Bruno Farah, Didier Carrié, Simon Walsh, Keith Oldroyd, Olivier Varenne, Seif El-Jack, Raul Moreno, Thomas Christen, Dominic J Allocco
AIMS: Long-term data for bioabsorbable polymer-coated everolimus-eluting stents (BP-EES) are limited. The EVOLVE trial compared the safety and efficacy of 2 dose formulations of SYNERGY BP-EES with permanent polymer-coated PROMUS Element EES (PE). METHODS AND RESULTS: The EVOLVE study was a prospective, multicentre, noninferiority trial that randomised 291 patients with de novo coronary lesions (length: ≤28mm; diameter: ≥2.25 to ≤3.5 mm) to receive PE (n=98), SYNERGY (n=94), or SYNERGY half-dose (n=99)...
September 19, 2017: EuroIntervention
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