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Synergy stent

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https://www.readbyqxmd.com/read/27879518/three-month-evaluation-of-strut-healing-using-a-novel-optical-coherence-tomography-analytical-method-following-bioresorbable-polymer-everolimus-eluting-stent-implantation-in-humans-the-timeless-study
#1
Boris Vesga, Hector Hernandez, Miguel Moncada, Pawel Gasior, Sergio A H Leal, Antonio Dager, Camilo Arana, Juan A Delgado, Philippe Généreux, Akiko Maehara, Juan F Granada
AIMS: Bioresorbable polymer drug-eluting stent technologies have been considered to have the potential to enhance vascular healing by reducing polymer exposure to the vessel wall, potentially allowing the earlier discontinuation of dual antiplatelet therapy. At present, the early vascular healing response to this type of technologies is still unclear. PATIENTS AND METHODS: The TIMELESS study is a multicenter, prospective, single-arm study that enrolled real-world patients undergoing percutaneous coronary intervention...
November 22, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27807948/procedural-resources-utilization-and-clinical-outcomes-with-bioresorbable-everolimus-eluting-scaffolds-and-pt-cr-everolimus-eluting-stent-with-resorbable-abluminal-polymer-in-clinical-practice-a-randomized-trial
#2
Jose M de la Torre Hernandez, Tamara Garcia Camarero, Dae-Hyun Lee, Fermin Sainz Laso, Gabriela Veiga Fernandez, Tania Pino, Silvia Rubio, Pablo Legarra, Jorge R Valdivia, Javier Zueco Gil
OBJECTIVES: We sought to compare the procedural implications of using bioresorbable everolimus-eluting scaffolds (BVS) and Pt-Cr everolimus-eluting stent with abluminal bioabsorbable polymer (Synergy). BACKGROUND: There are important differences in the respective platforms, which could impact on procedural performance, complications and outcomes. METHODS: A prospective, randomized single center study including consecutive patients in stable clinical condition and with lesions amenable to be treated with BVS according to predefined criteria...
November 3, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27797291/everolimus-eluting-stents-or-bypass-surgery-for-left-main-coronary-artery-disease
#3
Gregg W Stone, Joseph F Sabik, Patrick W Serruys, Charles A Simonton, Philippe Généreux, John Puskas, David E Kandzari, Marie-Claude Morice, Nicholas Lembo, W Morris Brown, David P Taggart, Adrian Banning, Béla Merkely, Ferenc Horkay, Piet W Boonstra, Ad J van Boven, Imre Ungi, Gabor Bogáts, Samer Mansour, Nicolas Noiseux, Manel Sabaté, José Pomar, Mark Hickey, Anthony Gershlick, Pawel Buszman, Andrzej Bochenek, Erick Schampaert, Pierre Pagé, Ovidiu Dressler, Ioanna Kosmidou, Roxana Mehran, Stuart J Pocock, A Pieter Kappetein
Background Patients with obstructive left main coronary artery disease are usually treated with coronary-artery bypass grafting (CABG). Randomized trials have suggested that drug-eluting stents may be an acceptable alternative to CABG in selected patients with left main coronary disease. Methods We randomly assigned 1905 eligible patients with left main coronary artery disease of low or intermediate anatomical complexity to undergo either percutaneous coronary intervention (PCI) with fluoropolymer-based cobalt-chromium everolimus-eluting stents (PCI group, 948 patients) or CABG (CABG group, 957 patients)...
October 31, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27792651/comparison-of-vascular-responses-following-new-generation-biodegradable-and-durable-polymer-based-drug-eluting-stent-implantation-in-an-atherosclerotic-rabbit-iliac-artery-model
#4
Gaku Nakazawa, Sho Torii, Takeshi Ijichi, Hirofumi Nagamatsu, Yohei Ohno, Fumi Kurata, Ayako Yoshikawa, Masataka Nakano, Norihiko Shinozaki, Fuminobu Yoshimachi, Yuji Ikari
BACKGROUND: Incomplete endothelialization is the primary substrate of late stent thrombosis; however, recent reports have revealed that abnormal vascular responses are also responsible for the occurrence of late stent failure. The aim of the current study was to assess vascular response following deployment of biodegradable polymer-based Synergy (Boston Scientific) and Nobori (Terumo) drug-eluting stents and the durable polymer-based Resolute Integrity stent (Medtronic) in an atherosclerotic rabbit iliac artery model...
October 19, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27765302/impact-of-operator-experience-and%C3%A2-volume-on-outcomes-after-left%C3%A2-main%C3%A2-coronary-artery-percutaneous%C3%A2-coronary-intervention
#5
Bo Xu, Björn Redfors, Yuejin Yang, Shubin Qiao, Yongjian Wu, Jilin Chen, Haibo Liu, Jue Chen, Liang Xu, Yanyan Zhao, Changdong Guan, Runlin Gao, Philippe Généreux
OBJECTIVES: The aim of this study was to assess the impact of operator experience on prognosis after left main coronary artery (LM) percutaneous coronary intervention (PCI). BACKGROUND: LM PCI can be technically challenging and potentially risky considering the amount of supplied myocardium. METHODS: Consecutive patients who underwent unprotected LM PCI at a single institution were included and compared according to whether the primary operator was an experienced, high-volume LM operator (defined as an operator who performed at least 15 LM PCIs per year for at least 3 consecutive years) or not...
October 24, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27592016/major-predictors-of-long-term-clinical-outcomes-after-percutaneous-coronary-intervention-for-coronary-bifurcation-lesions-with-2-stent-strategy-patient-level-analysis-of-the-korean-bifurcation-pooled%C3%A2-cohorts
#6
Pil Sang Song, Young Bin Song, Joo Myung Lee, Joo-Yong Hahn, Seung-Hyuk Choi, Jin-Ho Choi, Sang Hoon Lee, Kyung Woo Park, Hyo-Soo Kim, Yangsoo Jang, Ki Bae Seung, Ju Hyeon Oh, Hyeon-Cheol Gwon
OBJECTIVES: This study investigated the long-term outcomes and predictors of target vessel failure (a composite of cardiac death, myocardial infarction, stent thrombosis, or target vessel revascularization) in patients with bifurcation lesion treated by percutaneous coronary intervention (PCI) utilizing the 2-stent strategy with a drug-eluting stent (DES). BACKGROUND: There are limited data on outcomes of the 2-stent strategy in bifurcation PCI. METHODS: Patient-level pooled analysis was performed with patients undergoing PCI with 2-stent strategy from the Korean Bifurcation Pooled Cohorts...
September 26, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27585503/outcomes-after-percutaneous-coronary-intervention-or-bypass-surgery-in-patients-with-unprotected-left-main-disease
#7
Rafael Cavalcante, Yohei Sotomi, Cheol W Lee, Jung-Min Ahn, Vasim Farooq, Hiroki Tateishi, Erhan Tenekecioglu, Yaping Zeng, Pannipa Suwannasom, Carlos Collet, Felipe N Albuquerque, Yoshinobu Onuma, Seung-Jung Park, Patrick W Serruys
BACKGROUND: Currently available randomized data on the comparison between percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) for the treatment of unprotected left main coronary disease (LMD) lacks statistical power due to low numbers of patients enrolled. OBJECTIVES: This study assessed long-term outcomes of PCI and CABG for the treatment of LMD in specific subgroups according to disease anatomic complexity. METHODS: We conducted a pooled analysis of individual patient-level data of the LMD patients included in the PRECOMBAT (Bypass Surgery Versus Angioplasty Using Sirolimus-Eluting Stent in Patients With Left Main Coronary Artery Disease) and SYNTAX (Synergy Between PCI With TAXUS and Cardiac Surgery) trials...
September 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27491605/individual-long-term-mortality-prediction%C3%A2-following-either-coronary-stenting-or%C3%A2-bypass-surgery-in-patients%C3%A2-with-multivessel-and-or-unprotected-left-main%C3%A2-disease-an-external-validation-of-the-syntax-score-ii-model-in-the-1-480-patients-of-the-best-and-precombat
#8
Yohei Sotomi, Rafael Cavalcante, David van Klaveren, Jung-Min Ahn, Cheol Whan Lee, Robbert J de Winter, Joanna J Wykrzykowska, Yoshinobu Onuma, Ewout W Steyerberg, Seung-Jung Park, Patrick W Serruys
OBJECTIVES: The study sought to validate the SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score II mortality prediction model after percutaneous coronary intervention (PCI) or coronary artery bypass grafting in a large pooled population of patients with multivessel coronary disease (MVD) and/or unprotected left main disease (UPLMD) enrolled in the PRECOMBAT (Bypass Surgery Versus Angioplasty Using Sirolimus-Eluting Stent in Patients With Left Main Coronary Artery Disease) and BEST (Artery Bypass Surgery and Everolimus-Eluting Stent Implantation in the Treatment of Patients with Multivessel Coronary Artery Disease) randomized controlled trials...
August 8, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27453515/evaluation-of-5-prognostic-scores-for-prediction-of-stroke-thromboembolic-and-coronary-events-all-cause-mortality-and-major-adverse-cardiac-events-in-patients-with-atrial-fibrillation-and-coronary-stenting
#9
Laurent Fauchier, Coralie Lecoq, Yann Ancedy, Karim Stamboul, Christophe Saint Etienne, Fabrice Ivanes, Denis Angoulvant, Dominique Babuty, Yves Cottin, Gregory Y H Lip
Management of antithrombotic therapy in patients with atrial fibrillation (AF) and coronary stenting remains challenging, and there is a need for efficient tools to predict their risk of different types of cardiovascular events and death. Several scores exist such as the CHA2DS2-VASc score, the Global Registry of Acute Coronary Events (GRACE) score, the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score, the Anatomical and Clinical Syntax II Score and the Reduction of Atherothrombosis for Continued Health score...
September 1, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27400317/over-expansion-capacity-and-stent-design-model-an-update-with-contemporary-des-platforms
#10
Jaryl Ng, Nicolas Foin, Hui Ying Ang, Jiang Ming Fam, Sayan Sen, Sukhjinder Nijjer, Ricardo Petraco, Carlo Di Mario, Justin Davies, Philip Wong
BACKGROUND: Previously, we examined the difference in stent designs across different sizes for six widely used Drug Eluting Stents (DESs). Although stent post-dilatation to larger diameter is commonly done, typically in the setting of long tapering segment or left-main PCI, there is an increasing recognition that information with regard to the different stent model designs has a critical impact on overexpansion results. This study aims to provide an update on stent model designs for contemporary DES platforms as well as test overexpansion results under with oversized post-dilatation...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27364047/long-term-mortality-after-coronary-revascularization-in-nondiabetic-patients-with-multivessel-disease
#11
Mineok Chang, Jung-Min Ahn, Cheol Whan Lee, Rafael Cavalcante, Yohei Sotomi, Yoshinobu Onuma, Erhan Tenekecioglu, Minkyu Han, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Seong-Wook Park, Patrick W Serruys, Seung-Jung Park
BACKGROUND: In diabetic patients with multivessel coronary artery disease (CAD), the survival difference between coronary artery bypass graft (CABG) surgery and percutaneous coronary intervention (PCI) favors CABG. However, there are few data on the mortality difference between the 2 strategies in nondiabetic patients. OBJECTIVES: This study performed a patient-level meta-analysis to compare the effect of CABG versus PCI with drug-eluting stents on long-term mortality in 1,275 nondiabetic patients with multivessel CAD...
July 5, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27357702/distal-longitudinal-deformation-of-a%C3%A2-synergy-stent-by-jailed-rotawire-guidewire
#12
A M Leong, P J L Ong, H H Ho, T Watson
Recent advances in stent technology have led to the development of thin strut platforms with fewer connectors. This has improved delivery but compromised strength, as illustrated by recent cases of longitudinal compression. We present an unusual case of longitudinal shortening at the distal end of a Synergy stent.
June 29, 2016: Herz
https://www.readbyqxmd.com/read/27313281/long-term-mortality-in-patients-with-radiation-associated-coronary-artery-disease-treated-with-percutaneous-coronary-intervention
#13
Grant W Reed, Ahmad Masri, Brian P Griffin, Samir R Kapadia, Stephen G Ellis, Milind Y Desai
BACKGROUND: The incidence and predictors of long-term mortality after percutaneous coronary intervention (PCI) for radiation-associated coronary artery disease are unknown. METHODS AND RESULTS: In this observational study of 314 patients (age, 65.2±11.4 years; 233 [74%] women) treated with PCI, 157 patients with previous external beam radiation therapy (XRT) were matched 1:1 with 157 comparison patients with atherosclerotic coronary artery disease without previous XRT, based on age, sex, lesion artery, and PCI type...
June 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27282597/coronary-artery-bypass-graft-surgery-and%C3%A2-percutaneous-coronary-interventions-in-patients-with-unprotected-left-main-coronary-artery-disease
#14
Zhe Zheng, Bo Xu, Heng Zhang, Changdong Guan, Ying Xian, Yanyan Zhao, Hongyang Fan, Yuejin Yang, Wei Wang, Runlin Gao, Shengshou Hu
OBJECTIVES: This study sought to investigate long-term clinical outcomes following coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) in patients with unprotected left main disease (ULMD). BACKGROUND: PCI has been increasingly used as an alternative mode of revascularization for ULMD. However, there are limited data comparing clinical outcomes between CABG surgery and PCI. METHODS: Between 2004 and 2010, 4,046 consecutive patients with ULMD were treated with either CABG surgery (n = 2,604) or PCI (n = 1,442) with drug-eluting stents...
June 13, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27198680/angiographic-and-clinical-outcomes-after%C3%A2-everolimus-eluting-stenting-for-unprotected-left-main-disease-and-high%C3%A2-anatomic-coronary-complexity
#15
Angela Migliorini, Renato Valenti, Guido Parodi, Ruben Vergara, Piergiovanni Buonamici, Giampaolo Cerisano, Nazario Carrabba, David Antoniucci
OBJECTIVES: This study determined angiographic and clinical outcomes after everolimus-eluting stent (EES)-supported percutaneous coronary intervention for unprotected left main disease (ULMD) and high SYNTAX (SYNergy between PCI with TAXus and Cardiac Surgery) trial score (≥33). BACKGROUND: The SYNTAX trial has shown the superiority of coronary surgery over percutaneous coronary intervention (PCI) in patients with ULMD and complex coronary anatomy. It has been hypothesized that, if newer generation drug-eluting stents had been used in the SYNTAX trial, there would have been a significant reduction in clinical events...
May 23, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/26936450/comparison-of-first-and-second-generation-drug-eluting-stent-efficacies-for-treating-left-main-and-or-three-vessel-disease-a-propensity-matched-study
#16
Norihiro Kobayashi, Yoshiaki Ito, Keisuke Hirano, Masahiro Yamawaki, Motoharu Araki, Tsuyoshi Sakai, Hideyuki Takimura, Yasunari Sakamoto, Shinsuke Mori, Masakazu Tsutsumi, Takuro Takama, Hiroya Takafuji, Takashi Maruyama, Yohsuke Honda, Takahiro Tokuda, Kenji Makino, Shigemitsu Shirai, Toshiya Muramatsu
The efficacy of second-generation drug-eluting stent (DES) for the treatment of left main disease (LM) and/or three vessel disease (3VD) remains unclear. We compared 2-year outcomes of second- versus first -generation DES implantation among patients with LM and/or 3VD and to assess the differential of risk by complexity of coronary artery disease using synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) scores. Between April 2007 and December 2012, 341 patients with LM and/or 3VD were treated by percutaneous coronary intervention; 154 with first-generation DES and 137 with second-generation DES...
March 2, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/26892080/left-main-stenting-in-comparison-with-surgical-revascularization-10-year-outcomes-of-the-left-main-coronary-artery-stenting-le-mans-trial
#17
Pawel E Buszman, Piotr P Buszman, Iwona Banasiewicz-Szkróbka, Krzysztof P Milewski, Aleksander Żurakowski, Bartłomiej Orlik, Magda Konkolewska, Błażej Trela, Adam Janas, Jack L Martin, R Stefan Kiesz, Andrzej Bochenek
OBJECTIVES: This study has reported 10-year clinical follow-up of patients enrolled in the prospective, randomized LE MANS (Left Main Stenting) trial. BACKGROUND: The very long-term outcome after left main stenting in comparison with surgical revascularization remains unknown. METHODS: In this prospective, multicenter trial, we randomly assigned 105 patients with unprotected left main coronary artery stenosis with low and medium complexity of coexisting coronary artery disease according to SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score to percutaneous coronary intervention (PCI) with stenting (n = 52) or coronary artery bypass grafting (CABG) (n = 53)...
February 22, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/26823484/impact-of-diabetic-status-on-outcomes-after-revascularization-with-drug-eluting-stents-in-relation-to-coronary-artery-disease-complexity-patient-level-pooled-analysis-of-6081-patients
#18
Konstantinos C Koskinas, George C M Siontis, Raffaele Piccolo, Anna Franzone, Alan Haynes, Julie Rat-Wirtzler, Sigmund Silber, Patrick W Serruys, Thomas Pilgrim, Lorenz Räber, Dik Heg, Peter Jüni, Stephan Windecker
BACKGROUND: Diabetes mellitus and angiographic coronary artery disease complexity are intertwined and unfavorably affect prognosis after percutaneous coronary interventions, but their relative impact on long-term outcomes after percutaneous coronary intervention with drug-eluting stents remains controversial. This study determined drug-eluting stents outcomes in relation to diabetic status and coronary artery disease complexity as assessed by the Synergy Between PCI With Taxus and Cardiac Surgery (SYNTAX) score...
February 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/26690312/the-synergy-ii-everolimus-eluting-stent-in-patients-older-than-75-years-undergoing-coronary-revascularisation-associated-with-a-short-dual-antiplatelet-therapy-senior-trial-rationale-and-design-of-a-large-scale-randomised-multicentre-study
#19
Olivier Varenne, Thomas Cuisset, Aurès Chaïb, Marie-Claude Morice, Manel Sabaté, Tian-Hai Koh, Isabelle Durand-Zaleski, Olivier Hanon, Kris Bogaerts, Peter Sinnaeve
AIMS: In the elderly population, bare metal stents (BMS) are often preferred over drug-eluting stents (DES) because of the longer duration of dual antiplatelet therapy (DAPT) associated with the latter. The SENIOR trial is designed to determine whether one of the latest generation of DES can reduce major cardiovascular events compared to BMS, despite a similar short DAPT duration. METHODS AND RESULTS: The SENIOR trial is a multicentre, single-blind, prospective, randomised trial comparing the latest generation DES (SYNERGY™ II; Boston Scientific, Marlborough, MA, USA) to BMS (Rebel™; Boston Scientific) in 1,200 patients ≥75 years old...
December 23, 2015: EuroIntervention
https://www.readbyqxmd.com/read/26614789/validation-of-the-ability-of-syntax-and-clinical-syntax-scores-to-predict-adverse-cardiovascular-events-after-stent-implantation-a-systematic-review-and-meta-analysis
#20
JiaYuan Chen, Buzhou Tang, YongQing Lin, Ying Ru, MaoXiong Wu, Xiaolong Wang, Qingcai Chen, YangXin Chen, JingFeng Wang
To compare the predicative ability of SYNTAX (Synergy between PCI with Taxus and Cardiac Surgery) and clinical SYNTAX scores for major adverse cardiac events (MACEs) after stent implantation in patients with coronary artery disease (CAD). Studies were identified by electronic and manual searches. Twenty-six studies were included in the meta-analysis. The pooled C-statistics of SYNTAX score for 1- and 5-year all-cause mortality (ACM) were 0.65 (95% confidence interval [CI]: 0.61-0.68) and 0.62 (95% CI: 0.59-0...
October 2016: Angiology
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