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https://www.readbyqxmd.com/read/29792733/feasibility-and-acceptability-of-nurse-led-primary-palliative-care-for-older-adults-with-chronic-conditions-a-pilot-study
#1
Shigeko Seiko Izumi, Basilia Basin, Margo Presley, Jean McCalmont, Jon P Furuno, Brie Noble, Judith G Baggs, J Randall Curtis
BACKGROUND: Many older adults live with serious illness for years before their death. Nurse-led primary palliative care could improve their quality of life and ability to stay in their community. OBJECTIVES: To assess feasibility and acceptability of a nurse-led Transitional Palliative Care (TPC) program for older adults with serious illness. METHODS: The study was a pilot trial of the TPC program in which registered nurses assisted patients with symptom management, communication with care providers, and advance care planning...
May 24, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29792422/toward-total-synthesis-of-thiolate-protected-metal-nanoclusters
#2
Qiaofeng Yao, Tiankai Chen, Xun Yuan, Jianping Xie
Total synthesis, where desired organic- and/or biomolecules could be produced from simple precursors at atomic precision and with known step-by-step reactions, has prompted centuries-lasting bloom of organic chemistry since its conceptualization in 1828 (Wöhler synthesis of urea). Such expressive science is also highly desirable in nanoscience, since it represents a decisive step toward atom-by-atom customization of nanomaterials for basic and applied research. Although total synthesis chemistry is less established in nanoscience, recent years have witnessed seminal advances and increasing research efforts devoted into this field...
May 24, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29792260/widening-participation-of-m%C3%A4-ori-and-pasifika-students-in-health-careers-evaluation-of-two-health-science-academies
#3
Lesley Middleton, Ausaga Faasalele Tanuvasa, Megan Pledger, Nicola Grace, Kirsten Smiler, Tua Taueetia Loto-Su'a, Jacqueline Cumming
Objective The aim of the present study was to evaluate the short-term outcomes of two health science academies established by a district health board in South Auckland, New Zealand, to create a health workforce pipeline for local Māori and Pasifika students. Methods A mixed-methods approach was used, involving background discussions with key informants to generate an initial logic model of how the academies work, followed by secondary analysis of students' records relating to retention and academic achievement, a survey of senior academy students' interest in particular health careers and face-to-face interviews and focus groups with students, families and teachers...
May 24, 2018: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29792129/exploring-intimate-partner-violence-before-during-and-after-pregnancy-in-bangladesh
#4
Md Jahirul Islam, Lisa Broidy, Paul Mazerolle, Kathleen Baird, Nurunnahar Mazumder
Intimate partner violence (IPV) against pregnant or postpartum women is known to have multiple detrimental effects on women and their children. Although results from past research suggest much continuity in trajectories of IPV, it is unclear whether pregnancy interrupts or augments these patterns. Little is known about how physical, sexual, and psychological IPV change and overlap throughout a woman's transition to parenthood. Relying on population-based data, this study examines the prevalence, co-occurring nature, and the changing patterns of physical, sexual, and psychological IPV before, during, and after pregnancy in Bangladesh...
May 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29792086/risk-of-further-surgery-on-the-same-or-opposite-side-and-mortality-after-primary-total-hip-arthroplasty-a-multi-state-analysis-of-133-654-patients-from-the-swedish-hip-arthroplasty-register
#5
Peter H J Cnudde, Szilard Nemes, Erik Bülow, A John Timperley, Sarah L Whitehouse, Johan Kärrholm, Ola Rolfson
Background and purpose - The hip-related timeline of patients following a total hip arthroplasty (THA) can vary. Ideally patients will live their life without need for further surgery; however, some will undergo replacement on the contralateral hip and/or reoperations. We analyzed the probability of mortality and further hip-related surgery on the same or contralateral hip. Patients and methods - We performed a multi-state survival analysis on a prospectively followed cohort of 133,654 Swedish patients undergoing an elective THA between 1999 and 2012...
May 23, 2018: Acta Orthopaedica
https://www.readbyqxmd.com/read/29790218/lost-in-transition-finding-a-path-forward-for-young-adults-with-type-1-diabetes
#6
L Laffel
In this issue of Diabetic Medicine, Kellett and colleagues describe the experiences of young persons with Type 1 diabetes in the UK as their needs and self-care efforts for diabetes management evolve during the university years [1]. In the 21st century, the topic of transitions in care for young people with various chronic diseases, in general, and with Type 1 diabetes, in particular, has become a popular and appealing area for cross-sectional, observational and interventional research globally [2]. Similarly, a number of national and international organizations have published clinical guidelines related to transition, although many of the clinical recommendations are based upon expert consensus rather than empirical data [3-7]...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29790020/can-we-accurately-predict-cost-effectiveness-without-access-to-overall-survival-data-the-case-study-of-nivolumab-in-combination-with-ipilimumab-for-the-treatment-of-patients-with-advanced-melanoma-in-england
#7
D Lee, A Amadi, J Sabater, J Ellis, H Johnson, S Kotapati, S McNamara, A Walker, M Cooper, K Patterson, N Roskell, Y Meng
BACKGROUND: Nivolumab with ipilimumab (the Regimen) is the first immuno-oncology combination treatment to demonstrate long-term clinical benefit for advanced melanoma patients. We evaluated the cost effectiveness of the Regimen in this population, with and without the availability of overall survival (OS) data. METHODS: A partitioned survival model and a Markov state-transition model were developed to estimate the lifetime costs and benefits of the Regimen versus ipilimumab...
May 22, 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29789993/the-role-of-the-epithelial-to-mesenchymal-transition-emt-in-diseases-of-the-salivary-glands
#8
REVIEW
Margherita Sisto, Sabrina Lisi, Domenico Ribatti
The link between inflammatory microenvironment and cancer emerged in the last years as a decisive factor in the induction of the pathological epithelial-mesenchymal transition (EMT). The EMT induces changes of cell states converting the epithelial cells to mesenchymal cells when this program is fully executed and EMT has emerged as a central driver of tumor malignancy. Cellular pathways activated by chronic inflammation brought about by chronic infections, by immune-mediated diseases, or by dysregulated wound healing at sites of repetitive tissue injury, constitute risk factors or initial cell transformation and for cancer progression...
May 23, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29789964/caring-for-women-with-multiple-sclerosis-across-the-lifespan
#9
REVIEW
Kelsey Rankin, Riley Bove
PURPOSE OF REVIEW: Caring for women with multiple sclerosis (MS), whose first symptoms typically begin during the childbearing years, requires a comprehensive approach to management across a range of reproductive exposures, and beyond through menopause. RECENT FINDINGS: This article summarizes what is known about the disease course in women with MS, how it differs from men, and the current state of knowledge regarding effects of reproductive exposures (menarche, childbearing, menopause) on MS-related inflammation and neurodegeneration...
May 23, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29789877/-meta-analyses-on-measurement-precision-of-non-invasive-hemodynamic-monitoring-technologies-in-adults
#10
G Pestel, K Fukui, M Higashi, I Schmidtmann, C Werner
An ideal non-invasive monitoring system should provide accurate and reproducible measurements of clinically relevant variables that enables clinicians to guide therapy accordingly. The monitor should be rapid, easy to use, readily available at the bedside, operator-independent, cost-effective and should have a minimal risk and side effect profile for patients. An example is the introduction of pulse oximetry, which has become established for non-invasive monitoring of oxygenation worldwide. A corresponding non-invasive monitoring of hemodynamics and perfusion could optimize the anesthesiological treatment to the needs in individual cases...
May 22, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29789717/multicellular-detachment-generates-metastatic-spheroids-during-intra-abdominal-dissemination-in-epithelial-ovarian-cancer
#11
Sara Al Habyan, Christina Kalos, Joseph Szymborski, Luke McCaffrey
Ovarian cancer is the most lethal gynecological cancer, where survival rates have had modest improvement over the last 30 years. Metastasis of cancer cells is a major clinical problem, and patient mortality occurs when ovarian cancer cells spread beyond the confinement of ovaries. Disseminated ovarian cancer cells typically spread within the abdomen, where ascites accumulation aids in their transit. Metastatic ascites contain multicellular spheroids, which promote chemo-resistance and recurrence. However, little is known about the origin and mechanisms through which spheroids arise...
May 23, 2018: Oncogene
https://www.readbyqxmd.com/read/29788831/lumbosacral-transitional-vertebrae-in-cats-and-its-relationship-to-lumbosacral-vertebral-canal-stenosis
#12
Georgina Harris, Jessica Ball, Steven De Decker
Objectives Although a clear relationship has been demonstrated between the presence of lumbosacral transitional vertebrae and the development of lumbosacral stenosis in dogs, this relationship has not been evaluated in cats. The aim of this study was to investigate the relationship between the presence of lumbosacral transitional vertebrae and lumbosacral stenosis in cats. Methods The medical records and diagnostic imaging studies of 13 cats diagnosed with lumbosacral stenosis were retrospectively reviewed for lumbosacral abnormalities and compared with findings of 405 cats that underwent CT for reasons unrelated to spinal disease...
May 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29788749/university-life-with-asd-faculty-knowledge-and-student-needs
#13
Sasha M Zeedyk, Yasamine Bolourian, Jan Blacher
Increasingly, young adults with autism spectrum disorder are attending 4-year universities. The transition to adulthood can be challenging for these students, and university life poses its own set of demands. The present article takes a mixed-methods approach by including two studies utilizing complementary methodologies. Through in-depth interviews with students with autism spectrum disorder ( n = 13) and college professors ( n = 18), the purpose of the first study was to evaluate the experiences and needs of college students with autism spectrum disorder and identify the knowledge that faculty members possessed about working with these students...
May 1, 2018: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29788537/ten-years-of-medical-education-registrars-value-added
#14
Victoria Brazil, Lorna Davin
OBJECTIVE: There is a paucity of any long-term follow up of trainees' career pathways or organisational outcomes from medical education registrar posts in emergency medicine training. We report on the experience of a selected group of medical education trainees during and subsequent to their post and reflect on the value added to emergency medical education at three institutions. METHODS: We conducted an online survey study, examining quantitative outcomes and qualitative reflections, of emergency physicians who had previously undertaken a medical education registrar post...
May 22, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29788361/treatment-of-inflammatory-bowel-disease-in-the-older-patient
#15
Alastair Dorreen, Courtney Heisler, Jennifer Jones
The incidence of inflammatory bowel disease (IBD) is increasing, and as our population ages, there is a growing number of IBD patients who are transitioning into advanced age; 15% to 20% of IBD patients are classified as late-onset (between 60-65 years of age). This has led clinicians to treat a large number of older patients with IBD. The principles of management of IBD in older patients are the same as those who are younger. There are, however, phenotypic differences that are unique to late-onset IBD and age-related concerns that clinicians must consider when initiating therapy for their older patients with IBD...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788360/use-of-social-media-for-health-related-tasks-by-adolescents-with-inflammatory-bowel-disease-a-step-in-the-pathway-of-transition
#16
Winnie Szeto, Annelotte van der Bent, Carter R Petty, Jason Reich, Francis Farraye, Laurie N Fishman
Background: Social media is commonly used among the adolescent and young adult population, including those with chronic diseases. For adults, these platforms have been shown to be a major source of health information. Our aims were to explore how youth with inflammatory bowel disease (IBD) use social media for (1) disease information gathering, (2) provider communication, (3) sense of belonging to the IBD community, (4) self-expression around IBD, and (5) disease management/monitoring...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788230/tumor-infiltrating-lymphocytes-in-patients-receiving-trastuzumab-pertuzumab-based-chemotherapy-a-tryphaena-substudy
#17
Michail Ignatiadis, Gert Van den Eynden, Salgado Roberto, Marco Fornili, Yacine Bareche, Christine Desmedt, Françoise Rothé, Marion Maetens, David Venet, Esther Holgado, Virginia McNally, Astrid Kiermaier, Heidi M Savage, Timothy R Wilson, Javier Cortes, Andreas Schneeweiss, Karen Willard-Gallo, Elia Biganzoli, Christos Sotiriou
Background: There is an urgent requirement to identify biomarkers to tailor treatment in human epidermal growth factor receptor 2 (HER2)-amplified early breast cancer treated with trastuzumab/pertuzumab-based chemotherapy. Methods: Among the 225 patients randomly assigned to trastuzumab/pertuzumab concurrently or sequentially with an anthracycline-containing regimen or concurrently with an anthracycline-free regimen in the Tryphaena trial, we determined the percentage of tumor-infiltrating lymphocytes (TILs) at baseline in 213 patients, of which 126 demonstrated a pathological complete response (pCR; ypT0/is ypN0), with 28 demonstrating event-free survival (EFS) events...
May 18, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29788049/evidence-that-divergent-selection-shapes-a-developmental-cline-in-a-forest-tree-species-complex
#18
João Costa E Silva, Peter A Harrison, Robert Wiltshire, Brad M Potts
Background and Aims: Evolutionary change in developmental trajectories (heterochrony) is a major mechanism of adaptation in plants and animals. However, there are few detailed studies of the variation in the timing of developmental events among wild populations. We here aimed to identify the climatic drivers and measure selection shaping a genetic-based developmental cline among populations of an endemic tree species complex on the island of Tasmania. Methods: Seed lots from 38 native provenances encompassing the clinal transition from the heteroblastic Eucalyptus tenuiramis to the homoblastic Eucalyptus risdonii were grown in a common-garden field trial in southern Tasmania for 20 years...
May 19, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29786631/comparison-between-elite-and-subelite-swimmers-on-dry-land-and-tumble-turn-leg-extensor-force-time-characteristics
#19
Julian V Jones, David B Pyne, G Greg Haff, Robert U Newton
Jones, JV, Pyne, DB, Haff, GG, and Newton, RU. Comparison between elite and subelite swimmers on dry land and tumble turn leg extensor force-time characteristics. J Strength Cond Res 32(6): 1762-1769, 2018-Elite swimmers demonstrate faster swimming turn times that are potentially a result of having better strength-power characteristics than subelite swimmers. We quantified differences between dry-land and swimming turn force-time characteristics in elite swimmers and subelite swimmers. Subelite (11 males: 17...
June 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29784617/evolution-of-echocardiographic-measures-of-cardiac-disease-from-ckd-to-esrd-and-risk-of-all-cause-mortality-findings-from-the-cric-study
#20
Nisha Bansal, Jason Roy, Hsiang-Yu Chen, Rajat Deo, Mirela Dobre, Michael J Fischer, Elyse Foster, Alan S Go, Jiang He, Martin G Keane, John W Kusek, Emile Mohler, Sankar D Navaneethan, Mahboob Rahman, Chi-Yuan Hsu
RATIONALE & OBJECTIVE: Abnormal cardiac structure and function are common in chronic kidney disease (CKD) and end-stage renal disease (ESRD) and linked with mortality and heart failure. We examined changes in echocardiographic measures during the transition from CKD to ESRD and their associations with post-ESRD mortality. STUDY DESIGN: Prospective study. SETTING & PARTICIPANTS: We studied 417 participants with CKD in the Chronic Renal Insufficiency Cohort (CRIC) who had research echocardiograms during CKD and ESRD...
May 18, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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