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https://www.readbyqxmd.com/read/28743165/prognostic-factors-and-survival-outcomes-in-patients-with-chronic-myeloid-leukemia-in-blast-phase-in-the-tyrosine-kinase-inhibitor-era-cohort-study-of-477-patients
#1
Preetesh Jain, Hagop M Kantarjian, Ahmad Ghorab, Koji Sasaki, Elias J Jabbour, Graciela Nogueras Gonzalez, Rashmi Kanagal-Shamanna, Ghayas C Issa, Guillermo Garcia-Manero, Devendra Kc, Sara Dellasala, Sherry Pierce, Marina Konopleva, William G Wierda, Srdan Verstovsek, Naval G Daver, Tapan M Kadia, Gautam Borthakur, Susan O'Brien, Zeev Estrov, Farhad Ravandi, Jorge E Cortes
BACKGROUND: Outcomes in patients with chronic myeloid leukemia in blast phase (CML-BP) are historically dismal. Herein, the authors sought to analyze the characteristics, prognostic factors, and survival outcomes in patients with CML-BP in the tyrosine kinase inhibitor (TKI) era. METHODS: A total of 477 patients with CML-BP were treated with a TKI at some point during the course of their CML. Cox proportional hazard models identified characteristics that were predictive of survival...
July 25, 2017: Cancer
https://www.readbyqxmd.com/read/28743157/her2-mutations-in-lung-adenocarcinomas-a-report-from-the-lung-cancer-mutation-consortium
#2
Rathi N Pillai, Madhusmita Behera, Lynne D Berry, Mike R Rossi, Mark G Kris, Bruce E Johnson, Paul A Bunn, Suresh S Ramalingam, Fadlo R Khuri
BACKGROUND: Human epidermal growth factor receptor 2 (HER2) mutations have been reported in lung adenocarcinomas. Herein, the authors describe the prevalence, clinical features, and outcomes associated with HER2 mutations in 1007 patients in the Lung Cancer Mutation Consortium (LCMC). METHODS: Patients with advanced-stage lung adenocarcinomas were enrolled to the LCMC. Tumor specimens were assessed for diagnosis and adequacy; multiplexed genotyping was performed in Clinical Laboratory Improvement Amendments (CLIA)-certified laboratories to examine 10 oncogenic drivers...
July 25, 2017: Cancer
https://www.readbyqxmd.com/read/28742950/becoming-independent-political-participation-and-youth-transitions-in-the-scottish-referendum
#3
Maddie Breeze, Hugo Gorringe, Lynn Jamieson, Michael Rosie
Sociological debates on youth engagement with electoral politics play out against a backdrop of supposed 'decline' in civic participation (e.g. Putnam , Norris, ), in turn contextualized by theories of individualization in 'late' or 'reflexive' modernity (Beck, Giddens). However, the enfranchisement of 16 and 17 year olds in the 2014 Scottish Independence Referendum catalysed remarkably high levels of voter turnout among this youngest group, and was accompanied by apparently ongoing political engagement. We explored this engagement among a strategic sample of young 'Yes' voters, in the immediate aftermath of this exceptional political event...
July 25, 2017: British Journal of Sociology
https://www.readbyqxmd.com/read/28742412/post-high-school-changes-in-tobacco-and-cannabis-use-in-the-united-states
#4
Fearghal O'brien, Bruce Simons-Morton, Ashok Chaurasia, Jeremy Luk, Denise Haynie, Danping Liu
BACKGROUND: The transition from high school into young adulthood is a critical developmental period with many young people going to college, moving residence, and entering the work force for the first time. The NEXT Generation Health Study (NEXT) is a nationally representative longitudinal study of adolescent health behaviors. Previous NEXT research has found that the post-high school environment is associated with changes in alcohol use. OBJECTIVES: The current study investigated the impact of school status, residential status, and work status on cannabis and cigarette use among post-high school participants...
July 25, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28740776/tc-99m-human-serum-albumin-transit-time-as-a-measure-of-arm-breast-cancer-related-lymphedema
#5
Navid M Toyserkani, Svend Hvidsten, Siavosh Tabatabaeifar, Jane A Simonsen, Poul F Høilund-Carlsen, Jens A Sørensen
BACKGROUND: Lymphoscintigraphy has often been used for evaluating arm lymphatic dysfunction, but no optimal approach for quantification has so far emerged. We propose a quantifiable measure of lymphatic function that we applied in patients treated for breast cancer. METHODS: Eleven patients, aged 34-68 years, with unilateral arm lymphedema following breast cancer treatment underwent bilateral lymphoscintigraphy using intradermal injection in both hands of technetium-99m-labeled human serum albumin and sequential 5 min imaging for 5 hours...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28739834/change-in-physical-activity-from-adolescence-to-early-adulthood-a-systematic-review-and-meta-analysis-of-longitudinal-cohort-studies
#6
REVIEW
Kirsten Corder, Eleanor Winpenny, Rebecca Love, Helen Elizabeth Brown, Martin White, Esther van Sluijs
OBJECTIVE: To systematically review and meta-analyse how physical activity (PA) changes from adolescence to early adulthood (13-30 years). DATA SOURCES: Seven electronic databases were searched: Medline, Embase, PsycInfo, SCOPUS, ASSIA, SPORTdiscus and Web of Science. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: English-language, longitudinal studies (from 01/1980 to 01/2017) assessing PA ≥twice, with the mean age of ≥1 measurement in adolescence (13-19 years) and ≥1 in young adulthood (16-30 years) were included...
July 24, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28739498/increased-expression-of-ezh2-in-merkel-cell-carcinoma-is-associated-with-disease-progression-and-poorer-prognosis
#7
Kelly L Harms, Heather Chubb, Lili Zhao, Douglas R Fullen, Christopher K Bichakjian, Timothy M Johnson, Shannon Carskadon, Nallasivam Palanisamy, Paul W Harms
Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that affects tumorigenesis by epigenetic gene silencing. Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine carcinoma that has a high risk of disease progression with nodal and distant metastases. Here, we evaluated EZH2 expression by immunohistochemistry in a cohort of 85 MCC tumors (29 primary tumors, 41 lymph node metastases, 13 in-transit metastases, and 2 distant metastases) with clinical follow-up. We show strong/moderate EZH2 expression in 54% of tumors...
July 21, 2017: Human Pathology
https://www.readbyqxmd.com/read/28739430/evaluation-of-mr-imaging-targeted-biopsies-of-the-prostate-in-biopsy-na%C3%A3-ve-patients-a-single-centre-study
#8
J Garcia Bennett, J C Vilanova, J Gumà Padró, D Parada, A Conejero
PURPOSE: To evaluate the differences in prostate cancer detection rate and biopsy effectiveness between magnetic resonance imaging (MRI) target biopsy (TB) and transperineal standard biopsy (SB) in biopsy-naïve patients. MATERIAL AND METHODS: Between October 2014 and April 2016, 60 men with a mean age of 64.1±6.7 (SD) years (range: 53-82 years) were prospectively enrolled. All patients underwent a prostate MRI study, evaluated by two radiologists, before undergoing the biopsy...
July 21, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28739197/type-1-and-2-myocardial-infarction-and-myocardial-injury-clinical-transition-to-high-sensitivity-cardiac-troponin-i
#9
Yader Sandoval, Stephen W Smith, Anne Sexter, Sarah E Thordsen, Charles A Bruen, Michelle D Carlson, Kenneth W Dodd, Brian E Driver, Yan Hu, Katherine Jacoby, Benjamin K Johnson, Sara A Love, Johanna C Moore, Karen Schulz, Nathaniel L Scott, Fred S Apple
BACKGROUND: Studies addressing patients with type 2 myocardial infarction and myocardial injury, including the impact of using high-sensitivity (hs) cardiac troponin (cTn) assays on their incidence are needed. METHODS: Prospective, observational US cohort study. Consecutive emergency department patients with serial cTnI measurements. Outcomes included 180-day mortality and major adverse cardiac events, including 2-year follow-up for those with myonecrosis. RESULTS: Among 1,640 patients, using a contemporary cTnI assay, 30% (n=497) had ≥1 cTnI >99(th) percentile; with 4...
July 21, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28738450/the-effect-of-pressure-on-organic-reactions-in-fluids-a-new-theoretical-perspective
#10
REVIEW
Bo Chen, Roald Hoffmann, Roberto Cammi
This Review brings a new perspective to the study of chemical reactions in compressed fluid media. We begin by reviewing the substantial insight gained from more than 50 years of experimental studies on organic reactions in solution under pressure. These led to a proper estimation of the critical roles of volume of activation (Δ(≠) V) and reaction volume (ΔV) in understanding pressure effect on rates and equilibria of organic reactions. A recently developed computational method, the XP-PCM (extreme pressure polarizable continuum model) method, capable of carrying out quantum mechanical calculations of reaction pathways of molecules under pressure, is introduced...
July 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28738407/pain-and-learning-in-primary-school-a-population-based-study
#11
Silja Kosola, Lisa K Mundy, Susan M Sawyer, Louise Canterford, Danielle A van der Windt, Kate M Dunn, George C Patton
Despite the frequency of pain among children, little is known about its effects on learning and school outcomes. The objective of this study was to quantify the association of pain and academic achievement while taking into account the presence of co-occurring emotional symptoms. A population-based stratified random sample of 1239 students aged 8 to 9 years from primary schools in Melbourne, Australia, was recruited for the Childhood to Adolescence Transition Study. Children indicated sites of pain that had lasted for a day or longer in the past month using a pain manikin...
June 21, 2017: Pain
https://www.readbyqxmd.com/read/28737412/integrated-care-clinic-creating-enhanced-clinical-pathways-for-integrated-behavioral-health-care-in-a-family-medicine-residency-clinic-serving-a-low-income-minority-population
#12
Jerica M Berge, Lisa Trump, Stephanie Trudeau, Damir S Utržan, Michele Mandrich, Andrew Slattengren, Tanner Nissly, Laura Miller, Macaran Baird, Eli Coleman, Michael Wootten
INTRODUCTION: Research examining the implementation and effectiveness of integrated behavioral health (BH) care in family medicine/primary care is growing. However, research identifying ways to consistently use integrated BH in busy family medicine/primary care settings with underserved populations is limited. This study describes 1 family medicine clinic's transformation into a fully integrated BH care clinic through the development of an Integrated Care Clinic (ICC) and enhanced clinical pathways to promote regular use of behavioral health clinicians (BHCs)...
July 24, 2017: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/28737266/nephrolithiasis-a-complication-of-pediatric-diabetic-ketoacidosis
#13
Sungeeta Agrawal, Robin Kremsdorf, Serife Uysal, Meghan E Fredette, Lisa Swartz Topor
OBJECTIVE: To determine the frequency of nephrolithiasis as a complication of diabetic ketoacidosis (DKA) in pediatrics. METHODS: We performed a retrospective chart review of patients with DKA admitted to a pediatric hospital between January 2009 and July 2016. We identified patients with nephrolithiasis during admission for DKA. RESULTS: We identified 395 episodes of DKA over 7.5 years. Nephrolithiasis developed as a complication of DKA in 3 of those admissions (0...
July 24, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28736759/forecasted-trends-in-disability-and-life-expectancy-in-england-and-wales-up-to-2025-a-modelling-study
#14
Maria Guzman-Castillo, Sara Ahmadi-Abhari, Piotr Bandosz, Simon Capewell, Andrew Steptoe, Archana Singh-Manoux, Mika Kivimaki, Martin J Shipley, Eric J Brunner, Martin O'Flaherty
BACKGROUND: Reliable estimation of future trends in life expectancy and the burden of disability is crucial for ageing societies. Previous forecasts have not considered the potential impact of trends in disease incidence. The present prediction model combines population trends in cardiovascular disease, dementia, disability, and mortality to forecast trends in life expectancy and the burden of disability in England and Wales up to 2025. METHODS: We developed and validated the IMPACT-Better Ageing Model-a probabilistic model that tracks the population aged 35-100 years through ten health states characterised by the presence or absence of cardiovascular disease, dementia, disability (difficulty with one or more activities of daily living) or death up to 2025, by use of evidence-based age-specific, sex-specific, and year-specific transition probabilities...
July 2017: Lancet. Public Health
https://www.readbyqxmd.com/read/28735599/effectiveness-of-the-metslim-lifestyle-intervention-targeting-individuals-of-low-socio-economic-status-and-different-ethnic-origins-with-elevated-waist-to-height-ratio
#15
Andrea J Bukman, Dorit Teuscher, Agnes Meershoek, Reint Jan Renes, Marleen A van Baak, Edith Jm Feskens
OBJECTIVE: To evaluate whether the lifestyle intervention MetSLIM targeting individuals of low socio-economic status of Turkish, Moroccan and Dutch origin was successful in improving waist circumference and other cardiometabolic risk factors, lifestyle behaviour and quality of life. DESIGN: A quasi-experimental intervention study (Netherlands Trial Register NTR3721). The intervention group participated in a 12-month combined dietary and physical activity programme...
July 24, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28734908/why-transition-risk-to-psychosis-is-not-declining-at-the-oasis-ultra-high-risk-service-the-hidden-role-of-stable-pretest-risk-enrichment
#16
P Fusar-Poli, E Palombini, C Davies, D Oliver, I Bonoldi, V Ramella-Cravaro, P McGuire
BACKGROUND: The reason for declining risk to psychosis across individuals assessed and meeting Ultra High Risk (UHR) criteria is still unclear. No studies have investigated the potential substantial role of the underlying risk enrichment across all the individuals undergoing an UHR assessment. METHODS: Cohort study including all non-psychotic subjects who were assessed on suspicion of psychosis risk by the OASIS UHR service in the period 2001 to 2015. Posttest (after UHR assessment) and pretest risk (before UHR assessment) of psychosis were stratified and compared across three time periods (2001-2005, 2006-2010, 2011-2015) with Cox analysis and modulating factors were investigated...
July 19, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28734670/population-health-and-regional-variations-of-disease-burden-in-japan-1990-2015-a-systematic-subnational-analysis-for-the-global-burden-of-disease-study-2015
#17
Shuhei Nomura, Haruka Sakamoto, Scott Glenn, Yusuke Tsugawa, Sarah K Abe, Md M Rahman, Jonathan C Brown, Satoshi Ezoe, Christina Fitzmaurice, Tsuyoshi Inokuchi, Nicholas J Kassebaum, Norito Kawakami, Yosuke Kita, Naoki Kondo, Stephen S Lim, Satoshi Maruyama, Hiroaki Miyata, Meghan D Mooney, Mohsen Naghavi, Tomoko Onoda, Erika Ota, Yuji Otake, Gregory A Roth, Eiko Saito, Takahiro Tabuchi, Yohsuke Takasaki, Tadayuki Tanimura, Manami Uechi, Theo Vos, Haidong Wang, Manami Inoue, Christopher J L Murray, Kenji Shibuya
BACKGROUND: Japan has entered the era of super-ageing and advanced health transition, which is increasingly putting pressure on the sustainability of its health system. The level and pace of this health transition might vary across regions within Japan and concern is growing about increasing regional variations in disease burden. The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) provides a comprehensive, comparable framework. We used data from GBD 2015 with the aim to quantify the burden of disease and injuries, and to attribute risk factors in Japan at a subnational, prefecture-level...
July 19, 2017: Lancet
https://www.readbyqxmd.com/read/28734504/-relationship-between-family-variables-and-conjugal-adjustment
#18
Nerea Jiménez-Picón, Joaquín-Salvador Lima-Rodríguez, Marta Lima-Serrano
OBJECTIVE: To determine whether family variables, such as type of relationship, years of marriage, existence of offspring, number of members of family, stage of family life cycle, transition between stages, perceived social support, and/or stressful life events are related to conjugal adjustment. DESIGN: A cross-sectional and correlational study using questionnaires. LOCATION: Primary care and hospital units of selected centres in the province of Seville, Spain...
July 19, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28734323/parental-influences-on-heavy-episodic-drinking-development-in-the-transition-to-early-adulthood
#19
Aubrey Spriggs Madkour, Gretchen Clum, Thomas T Miles, Heng Wang, Kristina Jackson, Frances Mather, Arti Shankar
PURPOSE: The purpose of this study was to examine how parental relationship quality (communication frequency, time spent together, and closeness) during early adulthood is related to heavy episodic drinking (HED) during this developmental period and whether effects vary according to age, youth sex, or parent sex. METHODS: National data from the Panel Study of Income Dynamics-Transition to Adulthood Study were analyzed. Youth participated in up to four interviews (2005, 2007, 2009, and 2011; n = 1,320-1,489) between ages 18-25 years...
August 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28734226/inhibition-of-prb-pathway-differentially-modulates-apoptosis-in-esophageal-cancer-cells
#20
Rossana C Soletti, Deborah Biasoli, Nathassya A L V Rodrigues, João M A Delou, Renata Maciel, Vera L A Chagas, Rodrigo A P Martins, Stevens K Rehen, Helena L Borges
Esophageal cancer is the sixth most common cause of cancer-related death worldwide. Current chemotherapy regimens include a combination of 5-fluorouracil (5-FU) and cisplatin, but more efficient therapy strategies are needed to increase 5-year survival. Alterations in the signaling pathway of the tumor suppressor gene Rb-1, which encodes a phosphoprotein (pRB) that negatively regulates the G1/S transition of the cell cycle, are present in 70% of all tumors, but its role in esophageal cancer is still unclear...
July 19, 2017: Translational Oncology
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