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https://www.readbyqxmd.com/read/29675053/the-potential-effect-of-chinese-herbal-formula-hongqijiangzhi-fang-in-improving-nafld-focusing-on-nlrp3-inflammasome-and-gut-microbiota
#1
Shu Liang, Yupei Zhang, Yuanjun Deng, Yifang He, Yinji Liang, Zien Liang, Yanning Chen, Kairui Tang, Runsen Chen, Qinhe Yang
The present study investigates the potential therapeutic mechanism underlying the effects of the Chinese herbal formula Hongqijiangzhi Fang (HJF) on nonalcoholic fatty liver disease (NAFLD) in rats. Male Sprague Dawley (SD) rats were randomly divided into 4 groups ( n = 8): control group was fed a normal diet, three other groups were fed high-fat diets (HFD), and the two treatment groups were intragastrically given a compound probiotic or HJF during the molding time. After 16 w, related indices were detected...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29668928/akkermansia-muciniphila-can-reduce-the-damage-of-gluco-lipotoxicity-oxidative-stress-and-inflammation-and-normalize-intestine-microbiota-in-streptozotocin-induced-diabetic-rats
#2
Ling Zhang, Qianqian Qin, Manni Liu, Xiangling Zhang, Fang He, Guoqing Wang
This study aimed to investigate how Akkermansia muciniphila can implicate type 2 diabetes mellitus and the mechanisms underlying the effects Akkermansia muciniphila on type 2 diabetes mellitus. Normal and streptozotocin-induced diabetic Sprague-Dawley rats were orally administered with Akkermansia muciniphila and solvent. After four weeks of treatment, diabetic rats orally administered with live or pasteurized Akkermansia muciniphila exhibited significant increase in the blood concentration of high-density lipoprotein, and decrease in the hepatic glycogen, serum plasminogen activator inhibitor-1, tumor necrosis factor-α, lipopolysaccharide, malondialdehyde, and total glucagon-like peptide-1...
April 16, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29667480/the-human-gut-microbiota-metabolism-and-perspective-in-obesity
#3
Aline Corado Gomes, Christian Hoffmann, João Felipe Mota
The gut microbiota has been recognized as an important factor in the development of metabolic diseases such as obesity and is considered an endocrine organ involved in the maintenance of energy homeostasis and host immunity. Dysbiosis can change the functioning of the intestinal barrier and the gut-associated lymphoid tissues (GALT) by allowing the passage of structural components of bacteria, such as lipopolysaccharides (LPS), which activate inflammatory pathways that may contribute to the development of insulin resistance...
April 18, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29620942/food-withdrawal-alters-the-gut-microbiota-and-metabolome-in-mice
#4
Xiaojiao Zheng, Kejun Zhou, Yunjing Zhang, Xiaolong Han, Aihua Zhao, Jiajian Liu, Chun Qu, Kun Ge, Fengjie Huang, Brenda Hernandez, Herbert Yu, Jun Panee, Tianlu Chen, Weiping Jia, Wei Jia
Food withdrawal as a health-enhancing measure has beneficial effects on aging, disease prevention, and treatment. However, the cellular and molecular mechanisms involving gut microbial changes and metabolic consequences resulting from food withdrawal have yet to be elucidated. In this study, we subjected lean and obese mice to a dietary intervention that consisted of a 4-d complete food withdrawal and an 8-d 50% food withdrawal, and we studied changes in cecal microbiome and host serum metabolome. The abundance of potentially pathogenic Proteobacteria was decreased and Akkermansia muciniphila was elevated by food withdrawal in mice fed a high-fat diet (HFD)...
April 5, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29599513/akkermansia-muciniphila-is-permissive-to-arthritis-in-the-k-bxn-mouse-model-of-arthritis
#5
Matthew L Stoll, M Kathy Pierce, Jordan A Watkins, Mingce Zhang, Pamela F Weiss, Jennifer E Weiss, Charles O Elson, Randy Q Cron, Ranjit Kumar, Casey D Morrow, Trenton R Schoeb
Studies have identified abnormalities in the microbiota of patients with arthritis. To evaluate the pathogenicity of human microbiota, we performed fecal microbial transplantation from children with spondyloarthritis and controls to germ-free KRN/B6xNOD mice. Ankle swelling was equivalent in those that received patient vs. control microbiota. Principal coordinates analysis revealed incomplete uptake of the human microbiota with over-representation of two genera (Bacteroides and Akkermansia) among the transplanted mice...
March 24, 2018: Genes and Immunity
https://www.readbyqxmd.com/read/29572539/methodology-challenges-in-studying-human-gut-microbiota-effects-of-collection-storage-dna-extraction-and-next-generation-sequencing-technologies
#6
Marina Panek, Hana Čipčić Paljetak, Anja Barešić, Mihaela Perić, Mario Matijašić, Ivana Lojkić, Darija Vranešić Bender, Željko Krznarić, Donatella Verbanac
The information on microbiota composition in the human gastrointestinal tract predominantly originates from the analyses of human faeces by application of next generation sequencing (NGS). However, the detected composition of the faecal bacterial community can be affected by various factors including experimental design and procedures. This study evaluated the performance of different protocols for collection and storage of faecal samples (native and OMNIgene.GUT system) and bacterial DNA extraction (MP Biomedicals, QIAGEN and MO BIO kits), using two NGS platforms for 16S rRNA gene sequencing (Ilumina MiSeq and Ion Torrent PGM)...
March 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29571008/grape-proanthocyanidin-induced-intestinal-bloom-of-akkermansia-muciniphila-is-dependent-on-its-baseline-abundance-and-precedes-activation-of-host-genes-related-to-metabolic-health
#7
Li Zhang, Rachel N Carmody, Hetal M Kalariya, Rocio M Duran, Kristin Moskal, Alexander Poulev, Peter Kuhn, Kevin M Tveter, Peter J Turnbaugh, Ilya Raskin, Diana E Roopchand
We previously showed that C57BL/6J mice fed high-fat diet (HFD) supplemented with 1% grape polyphenols (GP) for 12 weeks developed a bloom of Akkermansia muciniphila with attenuated metabolic syndrome symptoms. Here we investigated early timing of GP-induced effects and the responsible class of grape polyphenols. Mice were fed HFD, low-fat diet (LFD) or formulations supplemented with GP (HFD-GP, LFD-GP) for 14 days. Mice fed HFD-GP, but not LFD-GP, showed improved oral glucose tolerance compared to controls...
February 15, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29566906/action-and-function-of-akkermansia-muciniphila-in-microbiome-ecology-health-and-disease
#8
REVIEW
Noora Ottman, Sharon Y Geerlings, Steven Aalvink, Willem M de Vos, Clara Belzer
The discovery of Akkermansia muciniphila has opened new avenues for the use of this abundant intestinal symbiont in next generation therapeutic products, as well as targeting microbiota dynamics. A. muciniphila is known to colonize the mucosal layer of the human intestine where it triggers both host metabolic and immune responses. A. muciniphila is particularly effective in increasing mucus thickness and increasing gut barrier function. As a result host metabolic markers ameliorate. The mechanism of host regulation is thought to involve the outer membrane composition, including the type IV pili of A...
December 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/29473096/influence-of-gemcitabine-chemotherapy-on-the-microbiota-of-pancreatic-cancer-xenografted-mice
#9
Concetta Panebianco, Kaarel Adamberg, Madis Jaagura, Massimiliano Copetti, Andrea Fontana, Signe Adamberg, Kaia Kolk, Raivo Vilu, Angelo Andriulli, Valerio Pazienza
BACKGROUND AND AIMS: Pancreatic ductal adenocarcinoma (PDAC) represents the fourth cause of cancer-related death. We aimed to evaluate whether gemcitabine treatment shapes the gut microbiota in a model of PDAC xenografted mice. MATERIALS AND METHODS: Pancreatic cancer xenograft mice were subjected to gemcitabine injection once per week for 3 weeks to assess the tumor volume as compared to control mice injected with normal saline solution. The composition of fecal microbiota, the activation of NF-kB pathway in cancer tissues and the serum metabolomics were further analyzed...
February 22, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29472701/akkermansia-muciniphila-derived-extracellular-vesicles-influence-gut-permeability-through-the-regulation-of-tight-junctions
#10
Chaithanya Chelakkot, Youngwoo Choi, Dae-Kyum Kim, Hyun T Park, Jaewang Ghim, Yonghoon Kwon, Jinseong Jeon, Min-Seon Kim, Young-Koo Jee, Yong S Gho, Hae-Sim Park, Yoon-Keun Kim, Sung H Ryu
The gut microbiota has an important role in the gut barrier, inflammation and metabolic functions. Studies have identified a close association between the intestinal barrier and metabolic diseases, including obesity and type 2 diabetes (T2D). Recently, Akkermansia muciniphila has been reported as a beneficial bacterium that reduces gut barrier disruption and insulin resistance. Here we evaluated the role of A. muciniphila-derived extracellular vesicles (AmEVs) in the regulation of gut permeability. We found that there are more AmEVs in the fecal samples of healthy controls compared with those of patients with T2D...
February 23, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29460206/deciphering-the-trophic-interaction-between-akkermansia-muciniphila-and-the-butyrogenic-gut-commensal-anaerostipes-caccae-using-a-metatranscriptomic-approach
#11
Loo Wee Chia, Bastian V H Hornung, Steven Aalvink, Peter J Schaap, Willem M de Vos, Jan Knol, Clara Belzer
Host glycans are paramount in regulating the symbiotic relationship between humans and their gut bacteria. The constant flux of host-secreted mucin at the mucosal layer creates a steady niche for bacterial colonization. Mucin degradation by keystone species subsequently shapes the microbial community. This study investigated the transcriptional response during mucin-driven trophic interaction between the specialised mucin-degrader Akkermansia muciniphila and a butyrogenic gut commensal Anaerostipes caccae. A...
February 19, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29432061/atorvastatin-treatment-modulates-the-gut-microbiota-of-the-hypercholesterolemic-patients
#12
Tariq Jamal Khan, Youssri M Ahmed, Mazin A Zamzami, Aisha M Siddiqui, Imran Khan, Othman A S Baothman, Mohamed G Mehanna, Abudukadeer Kuerban, Mohammed Kaleemuddin, Muhammad Yasir
Hypercholesterolemia is one of the most important risk factors for development of cardiovascular diseases. The composition of gut microbiota (total microbes residing in the gut) impacts on cholesterol and lipid metabolism. On the contrary, alterations in gut microbiota in response to hypercholesterolemia or drug treatment with atorvastatin (a cholesterol-lowering agent) are rarely investigated. We performed 16S rDNA amplicon sequencing to evaluate the gut bacterial community of 15 untreated hypercholesterolemic patients (HP) and 27 atorvastatin-treated hypercholesterolemic patients (At-HP) and compared with 19 healthy subjects (HS)...
February 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29393195/fecal-microbiome-and-food-allergy-in-pediatric-atopic-dermatitis-a-cross-sectional-pilot-study
#13
Karin B Fieten, Joan E E Totté, Evgeni Levin, Marta Reyman, Yolanda Meijer, André Knulst, Frank Schuren, Suzanne G M A Pasmans
BACKGROUND: Exposure to microbes may be important in the development of atopic disease. Atopic diseases have been associated with specific characteristics of the intestinal microbiome. The link between intestinal microbiota and food allergy has rarely been studied, and the gold standard for diagnosing food allergy (double-blind placebo-controlled food challenge [DBPCFC]) has seldom been used. We aimed to distinguish fecal microbial signatures for food allergy in children with atopic dermatitis (AD)...
January 25, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29379988/aberrant-intestinal-microbiota-in-individuals-with-prediabetes
#14
Kristine H Allin, Valentina Tremaroli, Robert Caesar, Benjamin A H Jensen, Mads T F Damgaard, Martin I Bahl, Tine R Licht, Tue H Hansen, Trine Nielsen, Thomas M Dantoft, Allan Linneberg, Torben Jørgensen, Henrik Vestergaard, Karsten Kristiansen, Paul W Franks, Torben Hansen, Fredrik Bäckhed, Oluf Pedersen
AIMS/HYPOTHESIS: Individuals with type 2 diabetes have aberrant intestinal microbiota. However, recent studies suggest that metformin alters the composition and functional potential of gut microbiota, thereby interfering with the diabetes-related microbial signatures. We tested whether specific gut microbiota profiles are associated with prediabetes (defined as fasting plasma glucose of 6.1-7.0 mmol/l or HbA1c of 42-48 mmol/mol [6.0-6.5%]) and a range of clinical biomarkers of poor metabolic health...
January 29, 2018: Diabetologia
https://www.readbyqxmd.com/read/29377524/model-driven-design-of-a-minimal-medium-for-akkermansia-muciniphila-confirms-mucus-adaptation
#15
Kees C H van der Ark, Steven Aalvink, Maria Suarez-Diez, Peter J Schaap, Willem M de Vos, Clara Belzer
The abundance of the human intestinal symbiont Akkermansia muciniphila has found to be inversely correlated with several diseases, including metabolic syndrome and obesity. A. muciniphila is known to use mucin as sole carbon and nitrogen source. To study the physiology and the potential for therapeutic applications of this bacterium, we designed a defined minimal medium. The composition of the medium was based on the genome-scale metabolic model of A. muciniphila and the composition of mucin. Our results indicate that A...
May 2018: Microbial Biotechnology
https://www.readbyqxmd.com/read/29339259/perturbations-of-gut-microbiome-genes-in-infants-with-atopic-dermatitis-according-to-feeding-type
#16
Min-Jung Lee, Mi-Jin Kang, So-Yeon Lee, Eun Lee, Kangjin Kim, Sungho Won, Dong In Suh, Kyung Won Kim, Youn Ho Sheen, Kangmo Ahn, Bong-Soo Kim, Soo-Jong Hong
BACKGROUND: Perturbations of the infant gut microbiota can shape development of the immune system and link to the risk of allergic diseases. OBJECTIVE: We sought to understand the role of the gut microbiome in patients with atopic dermatitis (AD). The metagenome of the infant gut microbiome was analyzed according to feeding types. METHODS: Composition of the gut microbiota was analyzed in fecal samples from 129 infants (6 months old) by using pyrosequencing, including 66 healthy infants and 63 infants with AD...
April 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29330443/an-insight-into-intestinal-mucosal-microbiota-disruption-after-stroke
#17
Dragana Stanley, Robert J Moore, Connie H Y Wong
Recent work from our laboratory has provided evidence that indicates selective bacterial translocation from the host gut microbiota to peripheral tissues (i.e. lung) plays a key role in the development of post-stroke infections. Despite this, it is currently unknown whether mucosal bacteria that live on and interact closely with the host intestinal epithelium contribute in regulating bacterial translocation after stroke. Here, we found that the microbial communities within the mucosa of gastrointestinal tract (GIT) were significantly different between sham-operated and post-stroke mice at 24 h following surgery...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29324224/good-bug-bad-bug-breaking-through-microbial-stereotypes
#18
Mihai Cirstea, Nina Radisavljevic, B Brett Finlay
Our expanding knowledge of microbial mechanisms is challenging the notion of "good" versus "bad" microbes and encouraging a better understanding of their roles in various contexts before their widespread therapeutic and clinical application. The intestinal microbe Akkermansia muciniphila, a promising probiotic with an emerging cautionary tale, best highlights this challenge.
January 10, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29304441/cloning-purification-and-biochemical-characterization-of-two-%C3%AE-n-acetylhexosaminidases-from-the-mucin-degrading-gut-bacterium-akkermansia-muciniphila
#19
Meng Wang, Xiao-Yang Zhang, Rui-Rui Guo, Zhi-Peng Cai, Xiao-Chun Hu, Huan Chen, Shuang Wei, Josef Voglmeir, Li Liu
Two genes encoding the β-N-acetylhexosaminidases Am2301 and Am2446 were cloned successfully from the mucin-degrading bacterium Akkermansia muciniphila. The recombinant enzymes with molecular masses of 61 kDa and 78 kDa were isolated and biochemically characterised. The optimum temperature of both enzymes was 37 °C, and the optimum pH was determined to be pH 5.0 for Am2301 and pH 6.5 for Am2446. The addition of sodium dodecyl sulphate (SDS) reduced the enzymes' activity significantly. Cu2+ -ions decreased the activity of Am2301 by 70%, while the activity of Am2446 was significantly reduced by Fe3+ -ions...
March 2, 2018: Carbohydrate Research
https://www.readbyqxmd.com/read/29297498/epithelial-hes1-maintains-gut-homeostasis-by-preventing-microbial-dysbiosis
#20
X-K Guo, J Ou, S Liang, X Zhou, X Hu
Recent advancements suggest that in addition to its roles in developmental processes, transcription repressor hairy and enhancer of split 1 (Hes1) also acts as a key regulator of inflammatory responses. A healthy gut microbiota ecology is critical for establishment of tissue homeostasis. However, the role of epithelial Hes1 in regulating intestinal microbiota ecology and intestinal homeostasis remains unexplored. Here we show that epithelial Hes1 deficiency leads to intestinal microbial dysbiosis and disturbed homeostasis...
January 3, 2018: Mucosal Immunology
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