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https://www.readbyqxmd.com/read/28527315/longitudinal-decline-in-speech-production-in-parkinson-s-disease-spectrum-disorders
#1
Sharon Ash, Charles Jester, Collin York, Olga L Kofman, Rachel Langey, Amy Halpin, Kim Firn, Sophia Dominguez Perez, Lama Chahine, Meredith Spindler, Nabila Dahodwala, David J Irwin, Corey McMillan, Daniel Weintraub, Murray Grossman
We examined narrative speech production longitudinally in non-demented (n=15) and mildly demented (n=8) patients with Parkinson's disease spectrum disorder (PDSD), and we related increasing impairment to structural brain changes in specific language and motor regions. Patients provided semi-structured speech samples, describing a standardized picture at two time points (mean±SD interval=38±24months). The recorded speech samples were analyzed for fluency, grammar, and informativeness. PDSD patients with dementia exhibited significant decline in their speech, unrelated to changes in overall cognitive or motor functioning...
May 17, 2017: Brain and Language
https://www.readbyqxmd.com/read/28527175/chorea-and-orofaciolingual-dystonia-in-a-40-year-old-male
#2
Lulup Kumar Sahoo, Kali Prasanna Swain, Ashok Kumar Mallick, Geeta Mohanty, Maheswar Samanta, Srikanta Kumar Sahoo
Neuroacanthocytosis is a heterogeneous group of disorders which result in progressive neurodegeneration, predominantly of the basal ganglia, and erythrocyte acanthocytosis. We report a case of neuroacanthocytosis with typical phenotype of choreoacanthocytosis. A 40 year male presented with features of chorea with orofaciolingual dystonia producing eating and speech difficulties. There were features of self mutilation in form of lip and tongue biting. Peripheral blood smear examination revealed acanthocytes in our patient...
April 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28516196/coupling-dynamics-in-speech-gestures-amplitude-and-rate-influences
#3
Pascal H H M van Lieshout
Speech is a complex oral motor function that involves multiple articulators that need to be coordinated in space and time at relatively high movement speeds. How this is accomplished remains an important and largely unresolved empirical question. From a coordination dynamics perspective, coordination involves the assembly of coordinative units that are characterized by inherently stable coupling patterns that act as attractor states for task-specific actions. In the motor control literature, one particular model formulated by Haken et al...
May 17, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28516192/the-value-of-gesell-score-in-predicting-the-outcome-of-cochlear-implantation-in-children
#4
Yang Yang, Liu Haihong, Zheng Jun, Chen Min, Li Ying, Hao Jinsheng, Liu Wei, Zhang Jie, Ni Xin
The purpose is to determine the value of preoperative evaluation on developmental levels using Gesell score in predicting the postoperative outcome in pediatric cochlear implantation (CI) recipients. 78 children who underwent CI were included in our study. Age at the time of CI ranged from 6 to 67 months. The Gesell score including adaptability, fine motor, gross motor, language, and social skill was used for evaluating the patients' developmental levels before the CI, and a developmental quotient (DQ) was calculated by the following formula: (developmental age/actual age) × 100...
May 17, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28514307/exome-sequencing-identifies-a-de-novo-mutation-of-ctnnb1-gene-in-a-patient-mainly-presented-with-retinal-detachment-lens-and-vitreous-opacities-microcephaly-and-developmental-delay-case-report-and-literature-review
#5
Niu Li, Yufei Xu, Guoqiang Li, Tingting Yu, Ru-En Yao, Xiumin Wang, Jian Wang
RATIONALE: The CTNNB1 (β-catenin) gene is well known for its crucial role in cell adhesion and the Wnt-signaling pathway. Previous studies have shown that gain-of-function mutations in the CTNNB1 gene contribute to the occurrence and development of a variety of carcinomas in humans. Recently, de novo, heterozygous, loss-of-function mutations of the CTNNB1 gene were found that partially explain intellectual disability in some patients. Other major clinical symptoms in these patients included microcephaly, abnormal facial features, motor delays, speech impairments, and deformities of the hands and feet...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28507360/psychometric-properties-of-conversion-disorder-scale-revised-cds-for-children
#6
Tazvin Ijaz, Attikah Nasir, Naema Sarfraz, Shirmeen Ijaz
OBJECTIVE: To revise conversion disorder scale and to establish the psychometric properties of the revised scale. METHODS: This case-control study was conducted from February to June, 2014, at the Government College University, Lahore, Pakistan, and comprised schoolchildren and children with conversion disorder. In order to generate items for revised version of conversion disorder scale, seven practising mental health professionals were consulted. A list of 42 items was finalised for expert ratings...
May 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28506484/a-surgical-approach-to-the-anatomo-functional-structure-of-language
#7
REVIEW
E Mandonnet
INTRODUCTION: Language is the most widely mapped cognitive function during brain surgery. Intraoperative language functional mapping using direct electrical stimulation under awake conditions is currently the gold standard technique for establishing the causal link between an area and a deficit that would be caused by its resection. It is also a powerful tool to investigate the anatomical correlates of current neuropsychological models of language. MATERIAL AND METHODS: The aim of this article is to reexamine the anatomo-functional structure of language that could be inferred from data obtained in direct electrical stimulation studies during awake surgery...
May 12, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28495044/cognitive-and-academic-outcomes-in-long-term-survivors-of-infantile-onset-pompe-disease-a-longitudinal-follow-up
#8
Gail A Spiridigliozzi, Lori A Keeling, Mihaela Stefanescu, Cindy Li, Stephanie Austin, Priya S Kishnani
This study examines the long-term cognitive and academic outcomes of 11 individuals with infantile onset Pompe disease (IOPD) (median age=11years, 1month, range=5years, 6months through 17years of age) treated with enzyme replacement therapy from an early age. All participants (7 males, 4 females) were administered individual intelligence tests (Wechsler or Leiter scales or both), a measure of their academic skill levels (Woodcock-Johnson Tests of Achievement), and a screening measure of visual-motor integration ability (Beery-Buktenica)...
May 1, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28494172/an-investigation-of-clear-speech-effects-on-articulatory-kinematics-in-talkers-with-als
#9
Mili Kuruvilla-Dugdale, Miguel Chuquilin-Arista
Amyotrophic lateral sclerosis (ALS) affects the speech motor system and causes a substantial decline in intelligibility. Clear speech strategies have been found to benefit intelligibility in talkers with dysarthria and the purpose of this study was to examine clear speech effects on tongue, lip, and jaw movements in persons with ALS and healthy controls. For this purpose, participants produced 10 repetitions of the sentence 'I owe you a yoyo' using both habitual and clear speech. Movement variability as well as maximum speed, range, and duration of movement of the articulators were obtained for both conditions...
May 11, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/28488902/designing-augmentative-and-alternative-communication-applications-the-results-of-focus-groups-with-speech-language-pathologists-and-parents-of-children-with-autism-spectrum-disorder
#10
Jamie B Boster, John W McCarthy
PURPOSE: The purpose of this study was to gain insight from speech-language pathologists (SLPs) and parents of children with autism spectrum disorder (ASD) regarding appealing features of augmentative and alternative communication (AAC) applications. METHOD: Two separate 1-hour focus groups were conducted with 8 SLPs and 5 parents of children with ASD to identify appealing design features of AAC Apps, their benefits and potential concerns. Participants were shown novel interface designs for communication mode, play mode and incentive systems...
May 10, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28483857/cortical-dynamics-of-disfluency-in-adults-who-stutter
#11
Ranit Sengupta, Shalin Shah, Torrey M J Loucks, Kristin Pelczarski, J Scott Yaruss, Katie Gore, Sazzad M Nasir
Stuttering is a disorder of speech production whose origins have been traced to the central nervous system. One of the factors that may underlie stuttering is aberrant neural miscommunication within the speech motor network. It is thus argued that disfluency (any interruption in the forward flow of speech) in adults who stutter (AWS) could be associated with anomalous cortical dynamics. Aberrant brain activity has been demonstrated in AWS in the absence of overt disfluency, but recording neural activity during disfluency is more challenging...
May 2017: Physiological Reports
https://www.readbyqxmd.com/read/28483485/sensory-motor-relationships-in-speech-production-in-post-lingually-deaf-cochlear-implanted-adults-and-normal-hearing-seniors-evidence-from-phonetic-convergence-and-speech-imitation
#12
Lucie Scarbel, Denis Beautemps, Jean-Luc Schwartz, Marc Sato
Speech communication can be viewed as an interactive process involving a functional coupling between sensory and motor systems. One striking example comes from phonetic convergence, when speakers automatically tend to mimic their interlocutor's speech during communicative interaction. The goal of this study was to investigate sensory-motor linkage in speech production in postlingually deaf cochlear implanted participants and normal hearing elderly adults through phonetic convergence and imitation. To this aim, two vowel production tasks, with or without instruction to imitate an acoustic vowel, were proposed to three groups of young adults with normal hearing, elderly adults with normal hearing and post-lingually deaf cochlear-implanted patients...
May 5, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28480166/albuterol-as-an-adjunctive-treatment-to-enzyme-replacement-therapy-in-infantile-onset-pompe-disease
#13
Yin-Hsiu Chien, Wuh-Liang Hwu, Ni-Chung Lee, Fuu-Jen Tsai, Dwight D Koeberl, Wen-Hui Tsai, Pao-Chin Chiu, Chaw-Liang Chang
BACKGROUND: Early initiation of enzyme replacement therapy (ERT) with recombinant human acid alpha-glucosidase is an effective treatment for patients with infantile-onset Pompe disease (IOPD) but cannot prevent a slow progression of myopathy. Albuterol has been shown to be helpful in adult patients with Pompe disease, and therefore, we administered an open-label adjunctive therapy with albuterol in IOPD patients undergoing ERT. METHODS: Fourteen patients, aged 2 to 12 years, were enrolled in this study; all of them had a disease onset before 12 months of life, and 13 of them were ambulatory because of early initiation of ERT...
June 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/28479488/the-development-of-offspring-from-mothers-with-systemic-lupus-erythematosus-a-systematic-review
#14
REVIEW
Fjodor A Yousef Yengej, Annet van Royen-Kerkhof, Ronald H W M Derksen, Ruth D E Fritsch-Stork
OBJECTIVE: To analyze published data on the influence of maternal systemic lupus erythematosus (SLE) on different aspects of child development. METHODS: A systematic review was conducted using PubMed and Embase searches for SLE or SLE-related antibodies and physical, neurocognitive, psychiatric or motor development outcomes in children. RESULTS: In total 24 cohort and 4 case-control studies were included after initial screening of 1853 hits...
May 4, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28477351/normalization-of-timed-neuropsychological-tests-with-the-pata-rate-and-nine-hole-pegboard-tests
#15
Francesco Saccà, Teresa Costabile, Filomena Abate, Agnese Liguori, Francesca Paciello, Chiara Pane, Anna De Rosa, Fiore Manganelli, Giuseppe De Michele, Alessandro Filla
INTRODUCTION: Despite neurological patients show frequent physical impairment, timed neuropsychological tests do not take this into account during scoring procedures. OBJECTIVE: We propose a normalization method based on the PATA Rate Task (PRT) and on the nine-hole pegboard test (9HPT) as a measure of dysarthria and upper limb dysfunction. METHODS: We tested 65 healthy controls on timed neuropsychological tests (Attentional Matrices [AM], Trail Making Test, Symbol Digit Modalities Test, Verbal Fluencies) to determine the time spent on phonation or on hand movement during test execution...
May 6, 2017: Journal of Neuropsychology
https://www.readbyqxmd.com/read/28475658/a-comparison-of-the-metalinguistic-performance-and-spelling-development-of-children-with-inconsistent-speech-sound-disorder-and-their-age-matched-and-reading-matched-peers
#16
Brigid C McNeill, Julie Wolter, Gail T Gillon
Purpose: This study explored the specific nature of a spelling impairment in children with speech sound disorder (SSD) in relation to metalinguistic predictors of spelling development. Method: The metalinguistic (phoneme, morphological, and orthographic awareness) and spelling development of 28 children ages 6-8 years with a history of inconsistent SSD were compared to those of their age-matched (n = 28) and reading-matched (n = 28) peers. Analysis of the literacy outcomes of children within the cohort with persistent (n = 18) versus resolved (n = 10) SSD was also conducted...
May 17, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28471206/the-complementary-roles-of-auditory-and-motor-information-evaluated-in-a-bayesian-perceptuo-motor-model-of-speech-perception
#17
Raphaël Laurent, Marie-Lou Barnaud, Jean-Luc Schwartz, Pierre Bessière, Julien Diard
There is a consensus concerning the view that both auditory and motor representations intervene in the perceptual processing of speech units. However, the question of the functional role of each of these systems remains seldom addressed and poorly understood. We capitalized on the formal framework of Bayesian Programming to develop COSMO (Communicating Objects using Sensory-Motor Operations), an integrative model that allows principled comparisons of purely motor or purely auditory implementations of a speech perception task and tests the gain of efficiency provided by their Bayesian fusion...
May 4, 2017: Psychological Review
https://www.readbyqxmd.com/read/28470820/semantic-richness-and-word-learning-in-children-with-autism-spectrum-disorder
#18
Allison Gladfelter, Lisa Goffman
Semantically rich learning contexts facilitate semantic, phonological, and articulatory aspects of word learning in children with typical development (TD). However, because children with autism spectrum disorder (ASD) show differences at each of these processing levels, it is unclear whether they will benefit from semantic cues in the same manner as their typical peers. The goal of this study was to track how the inclusion of rich, sparse, or no semantic cues influences semantic, phonological, and articulatory aspects of word learning in children with ASD and TD over time...
May 4, 2017: Developmental Science
https://www.readbyqxmd.com/read/28470385/the-metopic-sagittal-craniosynostosis-report-of-35-operative-cases
#19
Takeyoshi Shimoji, Takaoki Kimura, Kazuaki Shimoji, Masakazu Miyajima
PURPOSE: We have diagnosed 35 cases of the supposedly rare condition metopic-sagittal synostosis in the past 20 years. Here, we introduce their clinical symptoms, neuroradiological findings, and surgical treatment methods, as well as discuss the relevant literature. METHODS: Subjects included 35 patients (33 boys and 2 girls; mean age 4.2 years; range 1-8 years). Magnetic resonance imaging (MRI) confirmed that there were no abnormal findings in the brain. Thirty patients presented with symptoms including speech delay, hyperactivity, autistic tendency, motor impairment, self-mutilation, and panic/temper tantrum behaviors...
May 3, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28467888/auditory-object-perception-a-neurobiological-model-and-prospective-review
#20
Julie A Brefczynski-Lewis, James W Lewis
Interaction with the world is a multisensory experience, but most of what is known about the neural correlates of perception comes from studying vision. Auditory inputs enter cortex with its own set of unique qualities, and leads to use in oral communication, speech, music, and the understanding of emotional and intentional states of others, all of which are central to the human experience. To better understand how the auditory system develops, recovers after injury, and how it may have transitioned in its functions over the course of hominin evolution, advances are needed in models of how the human brain is organized to process real-world natural sounds and "auditory objects"...
April 30, 2017: Neuropsychologia
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