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Kan, herman

Erica K Schallert, J Herman Kan, Johanna Monsalve, Wei Zhang, George S Bisset, Scott Rosenfeld
No abstract text is available yet for this article.
April 4, 2016: Pediatric Radiology
Simon-Peter Williams, Annie Ogasawara, Jeff N Tinianow, Judith E Flores, David Kan, Jeffrey Lau, MaryAnn Go, Alexander N Vanderbilt, Herman S Gill, Li Miao, Joshua Goldsmith, Bonnee Rubinfeld, Weiguang Mao, Ron Firestein, Shang-Fan Yu, Jan Marik, Anton G T Terwisscha van Scheltinga
The efficacy of antibody-drug conjugates (ADCs) targeted to solid tumors depends on biological processes that are hard to monitor in vivo. 89Zr-immunoPET of the ADC antibodies could help understand the performance of ADCs in the clinic by confirming the necessary penetration, binding, and internalization. This work studied monomethyl auristatin E (MMAE) ADCs against two targets in metastatic castration-resistant prostate cancer, TENB2 and STEAP1, in four patient-derived tumor models (LuCaP35V, LuCaP70, LuCaP77, LuCaP96...
May 3, 2016: Oncotarget
Jong Woo Lee, Suzette LaRoche, Hyunmi Choi, Andres A Rodriguez Ruiz, Evan Fertig, Jeffrey M Politsky, Susan T Herman, Tobias Loddenkemper, Arnold J Sansevere, Pearce J Korb, Nicholas S Abend, Joshua L Goldstein, Saurabh R Sinha, Keith E Dombrowski, Eva K Ritzl, Michael B Westover, Jay R Gavvala, Elizabeth E Gerard, Sarah E Schmitt, Jerzy P Szaflarski, Kan Ding, Kevin F Haas, Richard Buchsbaum, Lawrence J Hirsch, Courtney J Wusthoff, Jennifer L Hopp, Cecil D Hahn
PURPOSE: The rapid expansion of the use of continuous critical care electroencephalogram (cEEG) monitoring and resulting multicenter research studies through the Critical Care EEG Monitoring Research Consortium has created the need for a collaborative data sharing mechanism and repository. The authors describe the development of a research database incorporating the American Clinical Neurophysiology Society standardized terminology for critical care EEG monitoring. The database includes flexible report generation tools that allow for daily clinical use...
April 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
Lawrence W-Y Wong, Jack W-H Kan, Thanh-ha Nguyen, Herman H-Y Sung, Dang Li, Alex S-F Au-Yeung, Rajpal Sharma, Zhenyang Lin, Ian D Williams
Bis(mandelato)borate [B(Man)2](-) (R- or S-) anions are simply prepared and appear widely effective for resolution of racemic cations. Three examples demonstrate their scope; the alkaloid tetrahydropalmatine (THP), 1,2-diaminopropane (1,2-dap) and the metal-organic complex [Co(phen)3](3+) are readily resolved, either by a facile one-pot procedure, or via counter-ion metathesis.
November 11, 2015: Chemical Communications: Chem Comm
Johanna Monsalve, J Herman Kan, Erica K Schallert, George S Bisset, Wei Zhang, Scott B Rosenfeld
OBJECTIVE: Osteomyelitis and septic arthritis clinically present at any age with overlapping signs and symptoms. The purposes of this study were to evaluate the demographic distribution of septic arthritis and osteomyelitis in children and to explore optimal imaging guidelines for these patients. MATERIALS AND METHODS: We performed a retrospective study of children up to 18 years old who were treated for osteomyelitis or septic arthritis between January 2011 and September 2013...
June 2015: AJR. American Journal of Roentgenology
Seema Jain, Derek J Williams, Sandra R Arnold, Krow Ampofo, Anna M Bramley, Carrie Reed, Chris Stockmann, Evan J Anderson, Carlos G Grijalva, Wesley H Self, Yuwei Zhu, Anami Patel, Weston Hymas, James D Chappell, Robert A Kaufman, J Herman Kan, David Dansie, Noel Lenny, David R Hillyard, Lia M Haynes, Min Levine, Stephen Lindstrom, Jonas M Winchell, Jacqueline M Katz, Dean Erdman, Eileen Schneider, Lauri A Hicks, Richard G Wunderink, Kathryn M Edwards, Andrew T Pavia, Jonathan A McCullers, Lyn Finelli
BACKGROUND: Incidence estimates of hospitalizations for community-acquired pneumonia among children in the United States that are based on prospective data collection are limited. Updated estimates of pneumonia that has been confirmed radiographically and with the use of current laboratory diagnostic tests are needed. METHODS: We conducted active population-based surveillance for community-acquired pneumonia requiring hospitalization among children younger than 18 years of age in three hospitals in Memphis, Nashville, and Salt Lake City...
February 26, 2015: New England Journal of Medicine
Erica K Schallert, J Herman Kan, Johanna Monsalve, Wei Zhang, George S Bisset, Scott Rosenfeld
BACKGROUND: Joint effusions identified by MRI may accompany osteomyelitis and determining whether the joint effusion is septic or reactive has important implications on patient care. OBJECTIVE: Determine the incidence of epiphyseal marrow edema, joint effusions, perisynovial edema and epiphyseal non-enhancement in the setting of pediatric metaphyseal osteomyelitis and whether this may be used to predict coexisting septic arthritis. MATERIALS AND METHODS: Following IRB approval, we retrospectively evaluated children who underwent MRI and orthopedic surgical consultation for suspected musculoskeletal infection between January 2011 and September 2013...
July 2015: Pediatric Radiology
J Herman Kan, Esben S Vogelius, Robert C Orth, R Paul Guillerman, Siddharth P Jadhav
BACKGROUND: Fragmentary ossification of the inferior patella is often dismissed as a normal variant in children younger than 10 years of age. OBJECTIVE: The purpose of this study was to determine whether fragmentary inferior patellar pole ossification is a normal variant or is associated with symptoms or signs of pathology using MRI and clinical exam findings as reference. MATERIALS AND METHODS: A retrospective review was performed on 150 patients ages 5-10 years who underwent 164 knee radiography and MRI exams (45...
June 2015: Pediatric Radiology
Wei Kan, Merel Adjobo-Hermans, Michael Burroughs, Guy Faibis, Sundeep Malik, Gregory G Tall, Alan V Smrcka
Phospholipase Cβ (PLCβ) enzymes are activated by G protein-coupled receptors through receptor-catalyzed guanine nucleotide exchange on Gαβγ heterotrimers containing Gq family G proteins. Here we report evidence for a direct interaction between M3 muscarinic receptor (M3R) and PLCβ3. Both expressed and endogenous M3R interacted with PLCβ in coimmunoprecipitation experiments. Stimulation of M3R with carbachol significantly increased this association. Expression of M3R in CHO cells promoted plasma membrane localization of YFP-PLCβ3...
April 18, 2014: Journal of Biological Chemistry
Haithuy N Nguyen, J Herman Kan, R Paul Guillerman, Christopher I Cassady
OBJECTIVE: The American College of Radiology recommends that fluoroscopically guided intussusception reduction be performed with a surgeon readily available. At many institutions, this may not be feasible. The purpose of this study was to assess the utilization of immediate surgical services at the time of radiologic intussusception reduction. MATERIALS AND METHODS: All radiologic intussusception reductions at a tertiary care children's hospital from November 2007 through August 2012 were reviewed to determine method, complications, clinical status of the child, and time between unsuccessful reduction and operative intervention...
February 2014: AJR. American Journal of Roentgenology
Sanaz Javadi, J Herman Kan, Robert C Orth, Marietta DeGuzman
OBJECTIVE: The purpose of this study was to characterize the extent of joint and tendon involvement in patients with juvenile idiopathic arthritis referred for MRI of the wrist or ankle. MATERIALS AND METHODS: Forty-five patients (32 female and 13 male patients; mean age, 10 years; age range, 1-19 years) with an established diagnosis of juvenile idiopathic arthritis were referred for MRI of the wrist or ankle between January 2000 and August 2012 (39 wrists and 33 ankles)...
February 2014: AJR. American Journal of Roentgenology
Zbigniew A Starosolski, J Herman Kan, Scott D Rosenfeld, Rajesh Krishnamurthy, Ananth Annapragada
Three-dimensional printing called rapid prototyping, a technology that is used to create physical models based on a 3-D computer representation, is now commercially available and can be created from CT or MRI datasets. This technical innovation paper reviews the specific requirements and steps necessary to apply biomedical 3-D printing of pediatric musculoskeletal disorders. We discuss its role for the radiologist, orthopedist and patient.
February 2014: Pediatric Radiology
Zeyad A Metwalli, J Herman Kan, Karuna A Munjal, Robert C Orth, Wei Zhang, R Paul Guillerman
OBJECTIVE: The purpose of this study was to determine the frequency of bilateral abnormalities in children with suspected lower extremity musculoskeletal infection and the impact of detection of contralateral abnormalities by MRI on patient management. MATERIALS AND METHODS: A retrospective review of 165 consecutive bilateral lower extremity MRI examinations performed for suspected musculoskeletal infection in pediatric patients (64% boys and 36% girls; mean age, 7...
August 2013: AJR. American Journal of Roentgenology
Lamya A Atweh, Robert C Orth, R Paul Guillerman, Wei Zhang, J Herman Kan
BACKGROUND: The added value of routine contrast-enhanced MR imaging in children with classic findings of osteonecrosis on unenhanced MR images has not been determined. OBJECTIVE: Our purpose was to determine the added value of routine contrast-enhanced MR sequences for identifying complications of osteonecrosis. MATERIAL AND METHODS: Sixty-four patients who underwent 139 contrast-enhanced MR examinations were retrospectively identified. Unenhanced images and subsequently both unenhanced and enhanced images were reviewed in consensus...
November 2013: Pediatric Radiology
Jared Guthrie Cobb, J Herman Kan, John C Gore
PURPOSE: To evaluate the feasibility of measuring T1ρ values in epiphyseal cartilage in children, we have conducted a novel study of spin locking techniques. Adult articular cartilage has been widely studied with spin locking techniques by magnetic resonance imaging. However, no results are available for in vivo T1ρ imaging of developing cartilage. MATERIALS AND METHODS: Ten volunteers of age 6 ± 3 years were recruited to have T1ρ mapping performed on the knee at the conclusion of their clinical study...
August 2013: Journal of Magnetic Resonance Imaging: JMRI
Chien-Tat Low, Poh-Chin Lai, Wing-Sze Cindy Tse, Chung-Kan Tsui, Herman Lee, Pak-Kwan Hui
Tuberculosis (TB) is known as a disease of poverty. It has also been related to poor living environment. This study examines the relationship between TB outcome and housing characteristics which is reflective of the socio-economic standing. We sought to investigate the association from two novel angles: (1) TB outcome against floor level of residence, and (2) TB outcome against types of housing development. A total of 1787 culture-positive TB cases were collected by the Centralized Mycobacterium Laboratory from 2007 to 2009...
June 2013: Social Science & Medicine
Yen-Ying Wu, Robert C Orth, R Paul Guillerman, Wei Zhang, J Herman Kan
OBJECTIVE: Radiographs are often obtained before MRI in the evaluation of pediatric knee pain, but the value of these radiographs is undefined. The purpose of this study was to determine the marginal value of knee radiographs in the interpretation of knee MR images requested by pediatric sports medicine and orthopedic subspecialists. MATERIALS AND METHODS: Knee MRI examinations of 194 pediatric patients (mean age, 14 [SD, 3.1] years; range 4-18 years) performed over a 3-year period were reviewed retrospectively...
April 2013: AJR. American Journal of Roentgenology
J Herman Kan
Juvenile idiopathic arthritis (JIA) represents a spectrum of non-pyogenic inflammatory arthritides affecting children. The purpose of this pictorial review is to illustrate the imaging spectrum of JIA and the role of radiology in disease diagnosis and management.
March 2013: Pediatric Radiology
Lamya A Atweh, J Herman Kan
Developmental dysplasia of the hip (DDH) is a spectrum disorder resulting in underdevelopment of the acetabulum. Radiographs and ultrasound are the mainstays for screening, with CT and MRI playing important roles in assessing outcome after treatment. The purpose of this article is to illustrate the use of multimodality imaging in the diagnosis and management of DDH.
March 2013: Pediatric Radiology
Randheer Shailam, Diego Jaramillo, J Herman Kan
Identification of congenital and acquired etiologies causing alignment disorders and leg-length discrepancies (LLD) in children is important for management. Minor differences in the lengths of the lower extremities are considered a normal variation and usually have no clinical significance. However, LLD of greater than 1 cm can cause altered biomechanics, resulting in scoliosis, back and lower extremity joint pain, pelvic tilt, abnormal gait and premature degenerative joint disease. The purpose of this pictorial essay is to review the imaging spectrum of growth arrest and resultant alignment and leg-length discrepancies in children...
March 2013: Pediatric Radiology
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