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https://www.readbyqxmd.com/read/28087106/charge-variant-analysis-of-proposed-biosimilar-to-trastuzumab
#1
Pravinkumar Dakshinamurthy, Pavithra Mukunda, Bhargav Prasad Kodaganti, Bharath Ravindra Shenoy, Bairavabalakumar Natarajan, Amol Maliwalave, Vivek Halan, Sathyabalan Murugesan, Sunit Maity
Trastuzumab is a humanized monoclonal antibody (mAb) employed for the treatment of HER2 Positive Breast Cancer. A HER2 overexpressing tumor cell binds to Trastuzumab and attracts immune cells which lead to induction of Antibody Dependent Cellular Cytotoxicity (ADCC) by binding to Fc receptors (CD16a or FcγRIIIa) on an effector cell, such as natural killer (NK) cells. The most commonly expressed receptor on NK cell is CD16a which binds to the Fc portion of Trastuzumab. The ligand-independent HER2-HER3 dimerization is the most potent stimulator of downstream pathways for regulation of cell growth and survival...
January 10, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28081068/plasmonic-wavelength-splitter-based-on-a-metal-insulator-metal-waveguide-with-a-graded-grating-coupler
#2
Yue Yu, Jiangnan Si, Yaying Ning, Minghai Sun, Xiaoxu Deng
A plasmonic wavelength splitter based on a sub-wavelength metal-insulator-metal (MIM) periodic rectangle wrinkle waveguide with a graded grating coupler is theoretically analyzed and experimentally demonstrated. The surface plasmon polaritons (SPPs), excited in the metal grating with wavelength selection, are deflected by the graded difference according to the aplanatic parametric principle. The wave vector of the deflected SPPs meets the phase-matching condition and couples into the periodic rectangle wrinkle waveguide with a plasmonic bandgap...
January 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28079185/high-efficiency-tri-band-quasi-continuous-phase-gradient-metamaterials-based-on-spoof-surface-plasmon-polaritons
#3
Yongfeng Li, Hua Ma, Jiafu Wang, Yongqiang Pang, Qiqi Zheng, Hongya Chen, Yajuan Han, Jieqiu Zhang, Shaobo Qu
A high-efficiency tri-band quasi-continuous phase gradient metamaterial is designed and demonstrated based on spoof surface plasmon polaritons (SSPPs). High-efficiency polarizaiton conversion transmission is firstly achieved via tailoring phase differece between the transmisive SSPP and the space wave in orthogonal directions. As an example, a tri-band circular-to-circular (CTC) polarization conversion metamateiral (PCM) was designed by a nonlinearly dispersive phase difference. Using such PCM unit cell, a tri-band quasi-continuous phase gradient metamaterial (PGM) was then realized by virtue of the Pancharatnam-Berry phase...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28078339/simultaneous-topographical-electrical-and-optical-microscopy-of-optoelectronic-devices-at-the-nanoscale
#4
Naresh Kumar, Alina Zoladek-Lemanczyk, Anne A Y Guilbert, Weitao Su, Sachetan M Tuladhar, Thomas Kirchartz, Bob C Schroeder, Iain McCulloch, Jenny Nelson, Debdulal Roy, Fernando A Castro
Novel optoelectronic devices rely on complex nanomaterial systems where the nanoscale morphology and local chemical composition are critical to performance. However, the lack of analytical techniques that can directly probe these structure-property relationships at the nanoscale presents a major obstacle to device development. In this work, we present a novel method for non-destructive, simultaneous mapping of the morphology, chemical composition and photoelectrical properties with <20 nm spatial resolution by combining plasmonic optical signal enhancement with electrical-mode scanning probe microscopy...
January 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28076951/a-multiscale-study-of-plasmonic-scattering-and-light-trapping-effect-in-silicon-nanowire-array-solar-cells
#5
Lingyi Meng, Yu Zhang, ChiYung Yam
Nanometallic structures that support surface plasmons provide new ways to confine light at deep-subwavelength scales. In this paper, the effect of light scattering in nanowire array solar cells is studied by a multiscale approach combining classical electromagnetics (EM) and quantum mechanical (QM) simulations. A photovoltaic device is constructed by integrating a silicon nanowire array with a plasmonic silver nanosphere. The light scatterings by plasmonic element and nanowire array are obtained via classical EM simulations while current-voltage characteristics and optical properties of the nanowire cells are evaluated quantum mechanically...
January 11, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28074853/plasmonic-plano-semi-cylindrical-nanocavities-with-high-efficiency-local-field-confinement
#6
Feifei Liu, Xinping Zhang, Xiaohui Fang
Plasmonic nanocavity arrays were achieved by producing isolated silver semi-cylindrical nanoshells periodically on a continuous planar gold film. Hybridization between localized surface plasmon resonance (LSPR) in the Ag semi-cylindrical nanoshells (SCNS) and surface plasmon polaritons (SPP) in the gold film was observed as split bonding and anti-bonding resonance modes located at different spectral positions. This led to strong local field enhancement and confinement in the plano-concave nanocavites. Narrow-band optical extinction with an amplitude as high as 1...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28074502/seedless-synthesis-of-monodispersed-gold-nanorods-with-remarkably-high-yield-synergistic-effect-of-template-modification-and-growth-kinetics-regulation
#7
Kang Liu, Yanru Bu, Yuanhui Zheng, Xuchuan Jiang, Aibing Yu, Huanting Wang
Gold nanorods (AuNRs) are versatile materials due to their broadly tuneable optical properties associated with the anisotropic feature. However, conventional seed-mediated synthesis is not only limited by the operational complexity and over-sensitivity towards subtle changes of experimental conditions, but also suffers from low yield (~15%). Herein, a facile seedless method is reported to overcome the above challenge. Monodispersed AuNRs with high yield (~100%) and highly adjustable longitudinal surface plasmon resonance (LSPR) are reproducibly synthesized...
January 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28073524/distribution-occurrence-and-biotoxin-composition-of-the-main-shellfish-toxin-producing-microalgae-within-european-waters-a-comparison-of-methods-of-analysis
#8
Sara E McNamee, Linda K Medlin, Jessica Kegel, Gary R McCoy, Robin Raine, Lucia Barra, Maria Valeria Ruggiero, Wiebe H C F Kooistra, Marina Montresor, Johannes Hagstrom, Eva Perez Blanco, Edna Graneli, Francisco Rodríguez, Laura Escalera, Beatriz Reguera, Simon Dittami, Bente Edvardsen, Joe Taylor, Jane M Lewis, Yolanda Pazos, Christopher T Elliott, Katrina Campbell
Harmful algal blooms (HABs) are a natural global phenomena emerging in severity and extent. Incidents have many economic, ecological and human health impacts. Monitoring and providing early warning of toxic HABs are critical for protecting public health. Current monitoring programmes include measuring the number of toxic phytoplankton cells in the water and biotoxin levels in shellfish tissue. As these efforts are demanding and labour intensive, methods which improve the efficiency are essential. This study compares the utilisation of a multitoxin surface plasmon resonance (multitoxin SPR) biosensor with enzyme-linked immunosorbent assay (ELISA) and analytical methods such as high performance liquid chromatography with fluorescence detection (HPLC-FLD) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) for toxic HAB monitoring efforts in Europe...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28072528/triosephosphate-isomerase-and-filamin-c-share-common-epitopes-as-novel-allergens-of-procambarus-clarkii
#9
Yang Yang, Yong-Xia Zhang, Meng Liu, Soheila J Maleki, Ming-Li Zhang, Qingmei Liu, Min-Jie Cao, Wen-Jin Su, Guang-Ming Liu
Triosephosphate isomerase (TIM) is a key enzyme in glycolysis and has been identified as an allergen in saltwater products. In this study, TIM with the molecular mass of 28 kDa was purified from the freshwater crayfish (Procambarus clarkii) muscle. A 90-kDa protein showed IgG/IgE cross-reactivity with TIM was purified and identified as filamin C (FLN c), which is an actin-binding proteins. TIM showed similar thermal and pH stability while better digestion resistant compared with FLN c. Result of surface plasmon resonance (SPR) experiment demonstrated the infinity of anti-TIM polyclonal antibody (pAb) to both TIM and FLN c...
January 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28071899/near-ir-absorbing-gold-nanoframes-with-enhanced-physiological-stability-and-improved-biocompatibility-for-in-vivo-biomedical-applications
#10
Liying Wang, Yunching Chen, Hsin Yao Lin, Yung-Te Hou, Ling-Chu Yang, Aileen Y Sun, Jia-Yu Liu, Chien-Wen Chang, Dehui Wan
This paper describes the synthesis of near-infrared (NIR)-absorbing gold nanoframes (GNFs) and a systematic study comparing their physiological stability and biocompatibility with those of hollow Au-Ag nanoshells (GNSs), which have been used widely as photothermal agents in biomedical applications because of their localized surface plasmon resonance (LSPR) in the NIR region. The GNFs were synthesized in three steps: galvanic replacement, Au deposition, and Ag dealloying, using silver nanospheres (SNP) as the starting material...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28070589/facile-three-dimensional-nanoarchitecturing-of-double-bent-gold-strips-on-roll-to-roll-nanoimprinted-transparent-nanogratings-for-flexible-and-scalable-plasmonic-sensors
#11
Jung-Sub Wi, Seungjo Lee, Sung Ho Lee, Dong Kyo Oh, Kyu-Tae Lee, Inkyu Park, Moon Kyu Kwak, Jong G Ok
We develop scalable 3D plasmonic nanoarchitectures comprising a double-bent nanoscale Au strip array integrated within the transparent nanograting framework, which can be continuously fabricated on a large-area flexible substrate via roll-to-roll nanoimprint lithography and angled Au deposition, realizing localized surface plasmon resonance with higher sensitivity in a smaller footprint.
January 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28069507/a-highly-versatile-adaptor-protein-for-the-tethering-of-growth-factors-to-gelatin-based-biomaterials
#12
Cyril Addi, Frédéric Murschel, Benoît Liberelle, Nesrine Riahi, Gregory De Crescenzo
: In the field of tissue engineering, the tethering of growth factors to tissue scaffolds in an oriented manner can enhance their activity and increase their half-life. We chose to investigate the capture of the basic Fibroblast Growth Factor (bFGF) and the Epidermal Growth Factor (EGF) on a gelatin layer, as a model for the functionalization of collagen-based biomaterials. Our strategy relies on the use of two high affinity interactions, that is, the one between two distinct coil peptides as well as the one occurring between a collagen-binding domain (CBD) and gelatin...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28069433/dual-recognition-activity-of-a-rhamnose-binding-lectin-to-pathogenic-bacteria-and-zooxanthellae-in-stony-coral-pocillopora-damicornis
#13
Zhi Zhou, Xiaopeng Yu, Jia Tang, Yunjie Zhu, Guangmei Chen, Liping Guo, Bo Huang
Rhamnose-binding lectin (RBL) is a type of Ca(2+)-independent lectin with tandem repeat carbohydrate-recognition domain, and is crucial for the innate immunity in many invertebrates. In this study, the cDNA sequence encoding RBL in coral Pocillopora damicornis (PdRBL-1) was cloned. The PdRBL-1 protein shared highest amino acid sequence similarity (55%) with the polyp of Hydra vulgaris, and contained a signal peptide and two tandem carbohydrate-recognition domains in which all cysteine residues were conserved...
January 6, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28068458/synthetic-muc1-glycopeptide-bearing-%C3%AE-galnac-thr-as-tn-antigen-isomer-induces-antibodies-production-against-tumor-cells
#14
Vanessa Leiria Campo, Thalita Riul, Leandro Bortot, Maristela Martins-Teixeira, Marcelo Marchiori, Emanuela Iaccarino, Menotti Ruvo, Marcelo Dias-Baruffi, Ivone Carvalho
This study presents the synthesis of the novel protected O-glycosyl amino acids βGalNAc-SerOBn (1) and βGalNAc-ThrOBn (2) as mimetics of the natural Tn antigen (αGalNAc-Ser/Thr), along with the solid-phase assembly of the glycopeptides NHAcSer-Ala-Pro-Asp-Thr[αGalNAc]-Arg-Pro-Ala-Pro-Gly-BSA (3-BSA) and NHAcSer-Ala-Pro-Asp-Thr[βGalNAc]-Arg-Pro-Ala-Pro-Gly-BSA (4-BSA), bearing αGalNAc-Thr or βGalNAc-Thr, as mimetics of MUC1 tumor mucin glycoproteins. According to ELISA tests, mice immunizations with βGalNAc-glycopeptide 4-BSA induced higher sera titers (1:320000) if compared to immunizations with αGalNAc-glycopeptide 3-BSA (1:40000)...
January 9, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28067766/wavelength-scanning-spr-imaging-sensors-based-on-an-acousto-optic-tunable-filter-and-a-white-light-laser
#15
Youjun Zeng, Lei Wang, Shu-Yuen Wu, Jianan He, Junle Qu, Xuejin Li, Ho-Pui Ho, Dayong Gu, Bruce Zhi Gao, Yonghong Shao
A fast surface plasmon resonance (SPR) imaging biosensor system based on wavelength interrogation using an acousto-optic tunable filter (AOTF) and a white light laser is presented. The system combines the merits of a wide-dynamic detection range and high sensitivity offered by the spectral approach with multiplexed high-throughput data collection and a two-dimensional (2D) biosensor array. The key feature is the use of AOTF to realize wavelength scan from a white laser source and thus to achieve fast tracking of the SPR dip movement caused by target molecules binding to the sensor surface...
January 5, 2017: Sensors
https://www.readbyqxmd.com/read/28067633/single-mode-tuning-of-the-plasmon-resonance-in-high-density-pillar-arrays
#16
Matthew David Arnold
The Maxwell-Garnett (MG) effective medium model has a pure resonance controlled by volume fraction f, but is usually invalid at high density. I present special 2D structures that match quasistatic MG over the entire range 0<f<1, in several regular and semi-regular arrays, expanding the applicability of MG. A key insight is the direct relationship between optimal surface polarization and surface position. Electrodynamic calculations underline the effect of constituent permittivity on spatial dispersion and required sizes for quasistatic response in various materials...
January 9, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28067530/infrared-absorption-and-hot-electron-production-in-low-electron-density-nanospheres-a-look-at-real-systems
#17
R Carmina Monreal, S Peter Apell, Tomasz J Antosiewicz
Doped semiconductor quantum dots are a new class of plasmonic systems exhibiting infrared resonances. At ultralow concentrations of charge carriers that can be achieved by controlled doping, only few carriers occupy each quantum dot; therefore, a spectrum with well-defined atomic-like peaks is expected. Here we investigate theoretically how surface imperfections and inhomogeneities in shape and morphology (surface "roughness") always present in these nanocrystals, randomize their energy levels, and blur the atomic-like features...
January 11, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28067433/plasmonic-imaging-of-the-interfacial-potential-distribution-on-bipolar-electrodes
#18
Meisam Hasheminejad, Yimin Fang, Meng Li, Yingyan Jiang, Wei Wang, Hong-Yuan Chen
Bipolar electrochemistry is based on the gradient distribution of free-electron density along an electrically isolated electrode, which causes a positive electrode potential at one end and a negative potential at the other, allowing for wide applications in analytical chemistry and materials science. To take full advantage of its wireless and high-throughput features, various types of optical probes, such as pH indicators and fluorescence and electrochemiluminescence reagents, have often been used to indirectly monitor the interfacial electron transfer through chromogenic or fluorogenic reactions...
January 9, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28067372/selective-turn-on-and-modulation-of-resonant-energy-transfer-in-single-plasmonic-hybrid-nanostructures
#19
Łukasz Bujak, Tatsuya Ishii, Dharmendar Kumar Sharma, Shuzo Hirata, Martin Vacha
Förster resonant energy transfer (FRET) is a nonradiative process by which the energy of light absorbed by a donor molecule is transferred to an acceptor molecule over a distance of several nanometers. FRET plays a crucial role in photosynthesis and nature-inspired artificial light-harvesting systems that are being explored for use in energy conversion applications. Localized plasmons of metal nanoparticles can potentially lead to a significant increase of FRET efficiency and effective donor-acceptor distance...
January 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/28067365/inverted-organic-solar-cells-enhanced-by-grating-coupled-surface-plasmons-and-waveguide-modes
#20
Kazuma Hara, Chutiparn Lertvachirapaiboon, Ryousuke Ishikawa, Yasuo Ohdaira, Kazunari Shinbo, Keizo Kato, Futao Kaneko, Akira Baba
In this study, we demonstrate improved photovoltaic properties in inverted organic thin-film solar cells by simultaneous excitation of grating-coupled surface plasmons and grating-coupled waveguide modes on gold grating surfaces. The cell consists of a glass-ITO substrate/titanium dioxide/poly(3-hexylthiophene-2,5-diyl):phenyl-C61-butyric acid methyl ester/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)/gold structure. The grating structures were fabricated on P3HT:PCBM layers using a nanoimprinting technique with a PDMS stamp...
January 9, 2017: Physical Chemistry Chemical Physics: PCCP
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