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malondialdehyde in heart failure

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https://www.readbyqxmd.com/read/29655692/effects-of-xin-ji-er-kang-on-heart-failure-induced-by-myocardial-infarction-role-of-inflammation-oxidative-stress-and-endothelial-dysfunction
#1
Juan Hu, Pan Cheng, Guang-Yao Huang, Guo-Wei Cai, Feng-Zhen Lian, Xiao-Yun Wang, Shan Gao
BACKGROUND: Xin-Ji-Er-Kang (XJEK) is a Chinese herbal formula, which has been reported to exert effective protection on cardiovascular diseases like hypertension and myocarditis. PURPOSE: To elucidate the protective effects of XJEK on heart failure (HF) induced by myocardial infarction (MI) through the amelioration of inflammation, oxidative stress (OS) and endothelial dysfunction(ED). MATERIALS AND METHODS: Fifty-seven male KM mice were randomized into the following six groups (n = 9-10 for each): control group, model group, MI+XJEK low dose group(XJEKL) group, MI+XJEK middle dose group(XJEKM), MI+XJEK high dose group(XJEKH), and MI+fosinopril group (positive control group)...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29620209/epigallocatechingallate-attenuates-myocardial-injury-in-a-mouse-model-of-heart-failure-through-tgf%C3%A2-%C3%AE-1-smad3-signaling-pathway
#2
Keyan Chen, Wei Chen, Shi Li Liu, Tian Shi Wu, Kai Feng Yu, Jing Qi, Yijun Wang, Hui Yao, Xiao Yang Huang, Ying Han, Ping Hou
The present study aimed to assess the protective effect of epigallocatechingallate (EGCG) against myocardial injury in a mouse model of heart failure and to determine the mechanism underlying regulation of the transforming growth factor‑β1/mothers against decapentaplegic homolog 3 (TGF‑β1/Smad3) signaling pathway. Mouse models of heart failure were established. Alterations in ejection fraction, left ventricular internal diastolic diameter (LVIDd) and left ventricular internal systolic diameter (LVIDs) were measured by echocardiography...
March 29, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29527002/sulforaphane-a-natural-isothiocyanate-compound-improves-cardiac-function-and-remodeling-by-inhibiting-oxidative-stress-and-inflammation-in-a-rabbit-model-of-chronic-heart-failure
#3
Tongliang Ma, Decai Zhu, Duoxue Chen, Qiaoyun Zhang, Huifang Dong, Wenwu Wu, Huihe Lu, Guangfu Wu
BACKGROUND The aim of this study was to investigate the effects of sulforaphane (SFN), a natural isothiocyanate compound, in a rabbit ascending aortic cerclage model of chronic heart failure (CHF). MATERIAL AND METHODS Thirty New Zealand White rabbits were divided into the sham operation group (n=10), the CHF group (n=10), and the CHF + SFN group (n=10) treated with subcutaneous SFN (0.5 mg/kg) for five days per week for 12 weeks. After 12 weeks, echocardiography and biometric analysis were performed, followed by the examination of the rabbit hearts...
March 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29323739/fasudil-alleviates-pressure-overload-induced-heart-failure-by-activating-nrf2-mediated-antioxidant-responses
#4
Peng Guan, Yingran Liang, Na Wang
The RhoA/Rho-kinase cascade plays an important role in many aspects of cardiovascular function. This study aims to investigate the protective effects of fasudil, a Rho-kinase inhibitor, on pressure overload induced heart failure in rats. Pressure overload induced heart failure was induced in SD rats by banding the abdominal aorta for 8 weeks. The rats were divided into four groups: Sham, TAC, TAC plus low dose of fasudil and TAC plus high dose of fasudil group. Low dose and high dose fasudil were 5 mg/kg/day and 10 mg/kg/day respectively...
January 11, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28864378/potential-cardiovascular-and-renal-protective-effects-of-vitamin-d-and-coenzyme-q-10-in-l-name-induced-hypertensive-rats
#5
Hanan A Shamardl, Sahar M El-Ashmony, Hala F Kamel, Sameer H Fatani
BACKGROUND: Hypertension is one of the primary modifiable risk factors for cardiovascular disease. Adequate vitamin D (vit D) levels have been shown to reduce vascular smooth muscle contraction and to increase arterial compliance, which may be beneficial in hypertension. Further, coenzyme Q10 (COQ10) through its action to lower oxidative stress has been reported to have beneficial effects on hypertension and heart failure. This study examined the possible cardiac and renal protective effects of vit D and COQ10 both separately and in combination with an angiotensin II receptor blocker, valsartan (vals) in l-NAME hypertensive rats...
August 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28793058/inflammation-and-oxidative-stress-in-heart-failure-effects-of-exercise-intensity-and-duration
#6
COMPARATIVE STUDY
G A Ribeiro-Samora, L A Rabelo, A C C Ferreira, M Favero, G S Guedes, L S M Pereira, V F Parreira, R R Britto
Although acute exercise is apparently pro-inflammatory and increases oxidative stress, it can promote the necessary stress stimulus to train chronic adaptations in patients with chronic heart failure (CHF). This study aimed to compare the effects of exercise intensity and duration on the inflammatory markers soluble tumor necrosis factor receptor (sTNFR1) and interleukin-6 (IL-6), and on oxidative stress [malondialdehyde (MDA) and antioxidant enzymes: catalase (CAT) and superoxide dismutase (SOD)] in individuals with CHF...
August 7, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28745354/soybean-isoflavones-ameliorate-ischemic-cardiomyopathy-by-activating-nrf2-mediated-antioxidant-responses
#7
RANDOMIZED CONTROLLED TRIAL
Yang Li, Haiyan Zhang
Ischemic cardiomyopathy (IC) is the major cause of heart failure. Conventional medicine has been proved ineffective with adverse effects. Soybean presents exciting adjunctive therapies and shows protective benefits for IC. However, the molecular mechanisms remain unclear. Isoflavones are the main bioactive components of soybean and may be protective against heart disease. Isoflavones were extracted by using an acidic-ethanol method and analyzed by HPLC. All patients with ischemic stroke were randomly and evenly assigned to two groups: the isoflavone group (80 mg day-1 , n = 100) and control group (80 mg day-1 placebo, n = 100), and the whole period of the experiment was 24 weeks...
August 1, 2017: Food & Function
https://www.readbyqxmd.com/read/28684113/sericin-improves-heart-and-liver-mitochondrial-architecture-in-hypercholesterolaemic-rats-and-maintains-pancreatic-and-adrenal-cell-biosynthesis
#8
Sumate Ampawong, Duangnate Isarangkul, Pornanong Aramwit
Hypercholesterolaemia is well known to be associated with mitochondrial dysfunction, subsequently leading to multiple organ failure. Similar to other natural products, sericin is a candidate for adjunctive therapy in hyperlipidaemic conditions. However, the cholesterol-lowering mechanisms of sericin are multifactorial and controversial. Here, a high-cholesterol-fed rat model with or without sericin treatment was established using a dosage of 1000mg/kg/day for 30 days. Blood lipid profiles, oxidative stress markers (superoxide dismutase, SOD; malondialdehyde, MDA; nuclear factor erythroid 2-related factor, Nrf-2), dysmorphic mitochondria in relation to fission (dynamin-related protein-1; Drp-1) and fusion (guanosine triphosphatase mutated in dominant optic atrophy; OPA-1) markers and biosynthetic markers (aquaporin, AQP-1; tubulin-4β, Tb4B) in the pancreas and adrenal gland were evaluated...
September 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28656216/hydrogen-containing-saline-alleviates-pressure-overload-induced-interstitial-fibrosis-and-cardiac-dysfunction-in-rats
#9
Jing Yang, Shujing Wu, Liqun Zhu, Jingjing Cai, Lu Fu
Cardiac fibrosis induced by sustained pressure overload contributes to heart failure. Oxidative stress serves an important role in cardiac remodeling and heart failure independent of etiological factors. The application of hydrogen as an antioxidant is a novel concept in disease treatment, however no studies as present have investigated the effects of hydrogen on cardiac fibrosis. In the present study, the effects of hydrogen on pressure overload‑induced cardiac fibrosis and heart failure were investigated in abdominal aortic‑constricted rats...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28627670/intermedin-improves-cardiac-function-and-sympathetic-neural-remodeling-in-a-rat-model-of-post-myocardial-infarction-heart-failure
#10
Bin Xu, Hao Xu, Heng Cao, Xiaoxiao Liu, Chunhuan Qin, Yanzhou Zhao, Xiaolin Han, Hongli Li
Emerging evidence has suggested that intermedin (IMD), a novel member of the calcitonin gene‑related peptide (CGRP) family, has a wide range of cardioprotective effects. The present study investigated the effects of long‑term administration of IMD on cardiac function and sympathetic neural remodeling in heart failure (HF) rats, and studied potential underlying mechanism. HF was induced in rats by myocardial infarction (MI). Male Sprague Dawley rats were randomly assigned to either saline or IMD (0.6 µg/kg/h) treatment groups for 4 weeks post‑MI...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28580831/markers-of-oxidative-stress-in-dogs-with-heart-failure
#11
Barbara Verk, Alenka Nemec Svete, Janez Salobir, Vida Rezar, Aleksandra Domanjko Petrič
We tested the hypothesis that indirect measures of oxidative stress (vitamin E, glutathione peroxidase, and malondialdehyde) differ in dogs in heart failure resulting from either myxomatous mitral valve disease or dilated cardiomyopathy. Dogs were classified according to the International Small Animal Cardiac Health Council (ISACHC) classification. Additionally, the effect of cardiac therapy on oxidative stress parameters and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in advanced stages of congestive heart failure was investigated...
June 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28407763/klotho-ameliorates-oxidized-low-density-lipoprotein-ox-ldl-induced-oxidative-stress-via-regulating-lox-1-and-pi3k-akt-enos-pathways
#12
Yansheng Yao, Yanbing Wang, Yibo Zhang, Chang Liu
BACKGROUND: Atherosclerosis is a common cardiovascular disease that causes myocardial infarction, heart failure, and stroke. Increased oxidized low density lipoprotein (ox-LDL) in the sub-endothelium is the characteristic origin of atherogenesis. Klotho, an anti-aging protein, has been reported to protect against atherosclerosis and ameliorate endothelial dysfunction in vivo. The aim of this study is to investigatethe anti-oxidative activity of Klothoin ox-LDL-treated human umbilical vein endothelial cells (HUVECs)...
April 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28406043/cardioprotective-effect-of-magnetic-hydrogel-nanocomposite-loaded-n-%C3%AE-l-rhamnopyranosyl-vincosamide-isolated-from-moringa-oleifera-leaves-against-doxorubicin-induced-cardiac-toxicity-in-rats-in-vitro-and-in-vivo-studies
#13
Mostafa Cheraghi, Mehrdad Namdari, Hadis Daraee, Babak Negahdari
Cardioprotective effect of N, α-L-rhamnopyranosyl vincosamide (VR), isolated from the leaves of Moringa oleifera plant in doxorubicin (Dox)-induced cardiac toxicity rats was evaluated. Twelve (12) rats were randomly selected into three groups; two rats received distilled water in the control group, five rats in group I received varying concentration of VR treatment, and group II containing five rats received varying concentration of VR-loaded magnetic hydrogel nanocomposite. Malondialdehyde (MDA), glutathione peroxidase (GSH) and superoxide dismutase (SOD) enzymes activities level were analysed after two weeks...
June 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28333655/biochemical-and-electrocardiographic-studies-on-the-beneficial-effects-of-gallic-acid-in-cyclophosphamide-induced-cardiorenal-dysfunction
#14
Omolola Rachel Ogunsanwo, Ademola Adetokunbo Oyagbemi, Temidayo Olutayo Omobowale, Ebunoluwa Racheal Asenuga, Adebowale Bernard Saba
Background Cardiac toxicity is one of the life-threatening complications of cancer therapy. Cyclophosphamide (CYP) is an alkylating agent with potent antineoplastic and immunosuppressive properties and possibly the most widely used antineoplastic agent. Chronic cardiotoxicity associated with CYP is characterized by progressive heart failure developing from weeks to years after therapy. Methods In this study, rats were administered with (60 mg/kg and 120 mg/kg) alone or in combination with single intraperitoneal (200 mg/kg) administration of CYP for 7 days...
March 22, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28296550/protective-effects-of-salusin-%C3%AE-and-salusin-%C3%AE-on-renal-ischemia-reperfusion-damage-and-their-levels-in-ischemic-acute-renal-failure
#15
M Cakir, H Duzova, A Taslidere, G Orhan, F Ozyalin
Salusin-α and salusin-β are expressed in many tissues including the central nervous system, vessels and kidneys; they have been shown to decrease endoplasmic reticulum stress during heart ischemia/reperfusion (I/R) and to decrease apoptosis. We investigated the relation of salusin-α and salusin-β levels to acute ischemic renal failure. We also investigated whether these peptides are protective against renal I/R damage. Fifty-three rats were divided into six groups: control, I/R, I/R + salusin-α1, I/R + salusin-α10, I/R + salusin-β1 and I/R + salusin-β10...
2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28237302/yiqifumai-powder-injection-attenuates-coronary-artery-ligation-induced-myocardial-remodeling-and-heart-failure-through-modulating-mapks-signaling-pathway
#16
Li-Zhi Pang, Ai-Chun Ju, Xian-Jie Zheng, Fang Li, Yun-Fei Song, Yan Zhao, Yuan-Feng Gu, Fei-Leng Chen, Chun-Hua Liu, Jin Qi, Zhen Gao, Jun-Ping Kou, Bo-Yang Yu
ETHNOPHARMACOLOGICAL RELEVANCE: YiQiFuMai Powder Injection (YQFM), a traditional Chinese medicine prescription re-developed based on Sheng-Mai-San, is a classical and traditional therapeutic for clinical heart failure (HF) and angina. However, its potential mechanism against HF remains unclear. AIM OF THE STUDY: The present study observes the therapeutic role of YQFM and mechanisms underlying its effects on coronary artery ligation (CAL)-induced myocardial remodeling (MR) and HF...
April 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28231545/aqueous-extract-of-cortex-dictamni-protects-h9c2-cardiomyocytes-from-hypoxia-reoxygenation-induced-oxidative-stress-and-apoptosis-by-pi3k-akt-signaling-pathway
#17
Lin Li, Yunfeng Zhou, Yanlin Li, Lili Wang, Lan Sun, Lidong Zhou, Hiderori Arai, Yun Qi, Yang Xu
Ischemia-reperfusion injury is the major manifestation of ischemic heart disease, which facilitates cardiac arrhythmias, heart failure and death. Oxidative stress and apoptosis have been involved in the pathogenesis of myocardial ischemia-reperfusion injury. Modern pharmacological studies have indicated that the extracts and active compounds of Cortex Dictamni exhibit antioxidative and cardiovascular protective activities. This study was designed to investigate the protective effect of aqueous extract of Cortex Dictamni (CDAE) on regulating hypoxia/reoxygenation (H/R)-induced cardiomyocytes oxidative stress and apoptosis...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28225475/stretching-exercises-improve-vascular-endothelial-dysfunction-through-attenuation-of-oxidative-stress-in-chronic-heart-failure-patients-with-an-implantable-cardioverter-defibrillator
#18
Michitaka Kato, Takashi Masuda, Michio Ogano, Kazuki Hotta, Hisato Takagi, Shinya Tanaka, Yumi Kamada, Ayako Akiyama, Daisuke Kamekawa, Ryosuke Shimizu, Minoru Tabata, Jun Tanabe, Takuya Umemoto
PURPOSE: Endurance training improves oxidative stress and vascular endothelial dysfunction in patients with chronic heart failure (CHF). However, patients with CHF and an implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy-defibrillator (CRT-D) often avoid endurance training for fear of ICD shock. Recent studies have reported that stretching exercises enhance antioxidant activity and improve vascular responses. Therefore, we aimed to assess the effects of 4 weeks of stretching exercises on oxidative stress and vascular endothelial function in patients with CHF with an ICD or CRT-D...
March 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28156163/post-infarct-sleep-disruption-and-its-relation-to-cardiac-remodeling-in-a-rat-model-of-myocardial-infarction
#19
Marjan Aghajani, Mahdieh Faghihi, Alireza Imani, Mohammad Reza Vaez Mahdavi, Abbas Shakoori, Tayebeh Rastegar, Hoda Parsa, Saman Mehrabi, Fatemeh Moradi, Ehsan Kazemi Moghaddam
Sleep disruption after myocardial infarction (MI) by affecting ubiquitin-proteasome system (UPS) is thought to contribute to myocardial remodeling and progressive worsening of cardiac function. The aim of current study was to test the hypothesis about the increased risk of developing heart failure due to experience of sleep restriction (SR) after MI. Male Wistar rats (n = 40) were randomly assigned to four experimental groups: (1) Sham, (2) MI, (3) MI and SR (MI + SR) (4) Sham and SR (Sham + SR). MI was induced by permanent ligation of left anterior descending coronary artery...
2017: Chronobiology International
https://www.readbyqxmd.com/read/28132441/markers-of-oxidative-stress-in-dogs-with-myxomatous-mitral-valve-disease-are-influenced-by-sex-neuter-status-and-serum-cholesterol-concentration
#20
M J Reimann, J Häggström, J E Møller, J Lykkesfeldt, T Falk, L H Olsen
BACKGROUND: Cardiovascular disease has been associated with oxidative stress, which has been suggested to contribute to myocardial remodeling in human patients. Little is known about the relationship between myxomatous mitral valve disease (MMVD) and oxidative stress in dogs. OBJECTIVE: To determine whether clinical stage of MMVD is associated with changes in the plasma concentrations of certain markers of oxidative stress in clinically healthy dogs and dogs with MMVD...
March 2017: Journal of Veterinary Internal Medicine
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