Marijan Tepes, Ivan Krezic, Hrvoje Vranes, Ivan Maria Smoday, Luka Kalogjera, Helena Zizek, Vlasta Vukovic, Katarina Oroz, Katarina Kasnik Kovac, Zrinko Madzar, Mislav Rakic, Blazenka Miskic, Suncana Sikiric, Ivan Barisic, Sanja Strbe, Marko Antunovic, Luka Novosel, Ivana Kavelj, Josipa Vlainic, Ivan Dobric, Mario Staresinic, Anita Skrtic, Sven Seiwerth, Alenka Boban Blagaic, Predrag Sikiric
Given in reperfusion, the use of stable gastric pentadecapeptide BPC 157 is an effective therapy in rats. It strongly counteracted, as a whole, decompression/reperfusion-induced occlusion/occlusion-like syndrome following the worst circumstances of acute abdominal compartment and intra-abdominal hypertension, grade III and grade IV, as well as compression/ischemia-occlusion/occlusion-like syndrome. Before decompression (calvariectomy, laparotomy), rats had long-lasting severe intra-abdominal hypertension, grade III (25 mmHg/60 min) (i) and grade IV (30 mmHg/30 min; 40 mmHg/30 min) (ii/iii), and severe occlusion/occlusion-like syndrome...
November 2, 2023: Pharmaceuticals