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malondialdehyde in heart failure

Moritz Brandt, Venkata Garlapati, Matthias Oelze, Efthymios Sotiriou, Maike Knorr, Swenja Kröller-Schön, Sabine Kossmann, Tanja Schönfelder, Henning Morawietz, Eberhard Schulz, Heinz-Peter Schultheiss, Andreas Daiber, Thomas Münzel, Philip Wenzel
Alcoholic cardiomyopathy (ACM) resulting from excess alcohol consumption is an important cause of heart failure (HF). Although it is assumed that the cardiotoxicity of the ethanol (EtOH)-metabolite acetaldehyde (ACA) is central for its development and progression, the exact mechanisms remain obscure. Murine cardiomyocytes (CMs) exposed to ACA or EtOH showed increased superoxide (O2(•-)) levels and decreased mitochondrial polarization, both being normalized by NADPH oxidase (NOX) inhibition. C57BL/6 mice and mice deficient for the ACA-degrading enzyme mitochondrial aldehyde dehydrogenase (ALDH-2(-/-)) were fed a 2% EtOH diet for 5 weeks creating an ACA-overload...
2016: Scientific Reports
Hiroki Ikenaga, Satoshi Kurisu, Shingo Kono, Yoji Sumimoto, Noriaki Watanabe, Takashi Shimonaga, Tadanao Higaki, Toshitaka Iwasaki, Naoya Mitsuba, Ken Ishibashi, Yoshihiro Dohi, Yukihiro Fukuda, Yasuki Kihara
BACKGROUND: Malondialdehyde-modified low-density lipoprotein (MDA-LDL) is considered to play an essential role in plaque destabilization. We aimed to investigate the association between the tissue characteristics of culprit plaque assessed by integrated backscatter (IB)-intravascular ultrasound (IVUS) and the serum MDA-LDL levels in patients with stable coronary artery disease. METHODS AND RESULTS: The study group consisted of 179 patients undergoing IB-IVUS during elective percutaneous coronary intervention...
September 23, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
Erminia Donnarumma, Shashi Bhushan, Jessica M Bradley, Hiroyuki Otsuka, Erinn L Donnelly, David J Lefer, Kazi N Islam
BACKGROUND: Bioavailability of nitric oxide (NO) and hydrogen sulfide (H2S) is reduced in heart failure (HF). Recent studies suggest cross-talk between NO and H2S signaling. We previously reported that sodium nitrite (NaNO2) ameliorates myocardial ischemia-reperfusion injury and HF. Nuclear factor-erythroid-2-related factor 2 (Nrf2) regulates the antioxidant proteins expression and is upregulated by H2S. We examined the NaNO2 effects on endogenous H2S bioavailability and Nrf2 activation in mice subjected to ischemia-induced chronic heart failure (CHF)...
2016: Journal of the American Heart Association
Paula F Martinez, Camila Bonomo, Daniele M Guizoni, Silvio A Oliveira Junior, Ricardo L Damatto, Marcelo D M Cezar, Aline R R Lima, Luana U Pagan, Fabio R Seiva, Renata T Bueno, Denise C Fernandes, Francisco R Laurindo, Leonardo A M Zornoff, Katashi Okoshi, Marina P Okoshi
BACKGROUND/AIMS: Although increased oxidative stress plays a role in heart failure (HF)-induced skeletal myopathy, signaling pathways involved in muscle changes and the role of antioxidant agents have been poorly addressed. We evaluated the effects of N-acetylcysteine (NAC) on intracellular signaling pathways potentially modulated by oxidative stress in soleus muscle from HF rats. METHODS AND RESULTS: Four months after surgery, rats were assigned to Sham, myocardial infarction (MI)-C (without treatment), and MI-NAC (treated with N-acetylcysteine) groups...
2016: Cellular Physiology and Biochemistry
Tansu Sav, Faruk Cecen, Enver S Albayrka
BACKGROUND: Cardiorenal syndrome (CRS) is defined as complex pathophysiological disorder of the heart and kidneys. Both heart and renal failure are characterized by increased systemic oxidative stress in CRS. The aim of the present study is to assess the impacts of ultrafiltration (UF) and furosemide treatment on oxidative stress markers and renal functions in patients with CRS. METHOD: 77 patients with CRS (37 patients in the UF group and 40 patients in the furosemide group) were included in the study...
April 20, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Cheng-Zhi Chai, Wei-Lan Mo, Xian-Fei Zhuang, Jun-Ping Kou, Yong-Qing Yan, Bo-Yang Yu
Right ventricular (RV) dysfunction and failure contribute to the increasing morbidity and mortality of cardiovascular diseases; however, current treatment strategies are grossly inadequate. Sheng-Mai-San (SMS) has been used to treat heart diseases for hundreds of years in China, and its protective effects on RV have not been observed. The present study was to investigate the protective effects of SMS aqueous extract on RV dysfunction in chronic intermittent hypoxia (CIH) mice model. The results showed that CIH mice model presented RV dysfunction and maladaptive compensation after 28-day-CIH and SMS treatment significantly reversed these changes...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Akbar Ahmad, Nadiya Druzhyna, Csaba Szabo
Cecal ligation and puncture (CLP)-induced sepsis is a serious medical condition, caused by a severe systemic infection resulting in a systemic inflammatory response. Recent studies have suggested the therapeutic potential of donors of hydrogen sulfide (H2S), a novel endogenous gasotransmitter and biological mediator in various diseases. The aim of the present study was to assess the effect of H2S supplementation in sepsis, with special reference to its effect on the modulation of regional blood flow. We infused sodium hydrosulfide (NaHS), a compound that produces H2S in aqueous solution (1, 3, or 10 mg/kg/h, for 1 h at each dose level) in control rats or rats 24 h after CLP, and measured blood flow using fluorescent microspheres...
August 2016: Shock
Wenguang Chang, Kun Li, Fengying Guan, Fan Yao, Yang Yu, Ming Zhang, Grant M Hatch, Li Chen
Preclinical and clinical studies have demonstrated that berberine (BBR) improves diabetic complications and reduces mortality of patients with congestive heart failure. The therapeutic effects of BBR have been reported to be mediated by its regulation of adenosine monophosphate (AMP)-activated protein kinase (AMPK). We previously reported that BBR protects against ischemia-reperfusion injury via regulating AMPK activity in both ischemic and nonischemic areas of the rat heart. Since diabetic hearts are more sensitive to ischemia-reperfusion injury, we examined whether BBR treatment exhibited cardioprotective effects in the diabetic heart...
September 2016: Journal of Cardiovascular Pharmacology and Therapeutics
Figen Barut, V Haktan Ozacmak, Inci Turan, Hale Sayan-Ozacmak, Erol Aktunc
PURPOSE: Multiple organ failure, including acute lung injury, is a common complication of intestinal ischemia and reperfusion (I/R) injury and contributes to its high mortality rate. Activated polymorphonuclear neutrophils and reactive oxygen species contribute to the lung injury caused by intestinal I/R. Mineralocorticoid receptor antagonist spironolactone has a protective effect against I/R injury in animal models of retina, kidney, heart, and brain. The aim of the present study is to investigate the effect of aldosterone receptor blocker spironolactone on lung injury induced by intestinal I/R...
February 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
Wei Zhang, Ming Peng, Yang Yang, Zhangwu Xiao, Bin Song, Zhaofen Lin
Exertional heat stroke (EHS) results in a constellation of systemic inflammatory responses resulting in multiorgan failure and an extremely high mortality. The present study was designed to evaluate the protective effects of salidroside on EHS by improving mitochondrial functions in the rat model. Liver and heart mitochondria were observed by transmission electron microscopy and mitochondrial membrane potential (ΔΨm) was detected by a fluorescent probe. Intramitochondrial free Ca(2+) concentration, mitochondrial respiratory control ratio (RCR), reactive oxygen species (ROS) levels, superoxide dismutase (SOD), and malondialdehyde (MDA) activity were detected by the corresponding kits...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
Oya Kerımoğlu, Sevınç Şahbaz, Özer Şehırlı, Zarıfe Nıgar Ozdemır, Şule Çetınel, Betül Dortunç, Göksel Şener
The objective of this study was to evaluate pharmacodynamical properties of transdermal therapeutic systems (TTS) containing captopril together with synthetic and pH independent polymers, Eudragit RL 100 and RS 100. Optimum formulation was chosen according to the results of our previous study regarding in vitro dissolution and ex vivo diffusion rate studies through excised human skin by using Franz Diffusion Cell. Control group, hypertension group (HT) and TTS containing captopril hypertension group (HT-CAP) were assessed for the pharmacodynamic activity of the study...
July 2015: Acta Poloniae Pharmaceutica
Ya-Hui Ko, Ming-Shian Tsai, Ru-Wen Chang, Chun-Yi Chang, Chih-Hsien Wang, Ming-Shiou Wu, Jin-Tung Liang, Kuo-Chu Chang
It has been shown that a prolonged low-dose corticosteroid treatment attenuates the severity of inflammation and the intensity and duration of organ system failure. In the present study, we determined whether low-dose methylprednisolone (a synthetic glucocorticoid) can protect male Wistar rats against cardiac pumping defects caused by lipopolysaccharide-induced chronic inflammation. For the induction of chronic inflammation, a slow-release ALZET osmotic pump was subcutaneously implanted to infuse lipopolysaccharide (1 mg kg(-1) d(-1)) for 2 weeks...
2015: Frontiers in Physiology
Aderville Cabassi, Simone Maurizio Binno, Stefano Tedeschi, Gallia Graiani, Cinzia Galizia, Michele Bianconcini, Pietro Coghi, Federica Fellini, Livia Ruffini, Paolo Govoni, Massimo Piepoli, Stefano Perlini, Giuseppe Regolisti, Enrico Fiaccadori
RATIONALE: Heart failure (HF) is accompanied by the development of an imbalance between oxygen- and nitric oxide-derived free radical production leading to protein nitration. Both chlorinating and peroxidase cycle of Myeloperoxidase (MPO) contribute to oxidative and nitrosative stress and are involved in tyrosine nitration of protein. Ceruloplasmin (Cp) has antioxidant function through its ferroxidase I (FeOxI) activity and has recently been proposed as a physiological defense mechanism against MPO inappropriate actions...
2015: BioMed Research International
Thomas L Lynch, Mayandi Sivaguru, Murugesan Velayutham, Arturo J Cardounel, Michelle Michels, David Barefield, Suresh Govindan, Cristobal dos Remedios, Jolanda van der Velden, Sakthivel Sadayappan
Cardiomyopathies can result from mutations in genes encoding sarcomere proteins including MYBPC3, which encodes cardiac myosin binding protein-C (cMyBP-C). However, whether oxidative stress is augmented due to contractile dysfunction and cardiomyocyte damage in MYBPC3-mutated cardiomyopathies has not been elucidated. To determine whether oxidative stress markers were elevated in MYBPC3-mutated cardiomyopathies, a previously characterized 3-month-old mouse model of dilated cardiomyopathy (DCM) expressing a homozygous MYBPC3 mutation (cMyBP-C((t/t))) was used, compared to wild-type (WT) mice...
2015: Oxidative Medicine and Cellular Longevity
Nandan K Mondal, Erik N Sorensen, Si M Pham, Steven C Koenig, Bartley P Griffith, Mark S Slaughter, Zhongjun J Wu
The role of oxidative stress and leukocyte activation has not been elucidated in developing systemic inflammatory response syndrome (SIRS) in heart failure (HF) patients after continuous-flow left ventricular assist device (CF-LVAD) implantation. The objective of this study was to investigate the change of plasma redox status and leukocyte activation in CF-LVAD implanted HF patients with or without SIRS. We recruited 31 CF-LVAD implanted HF patients (16 SIRS and 15 non-SIRS) and 11 healthy volunteers as the control...
May 2016: Artificial Organs
Urszula Paslawska, Liliana Kiczak, Jacek Bania, Robert Paslawski, Adrian Janiszewski, Piotr Dzięgiel, Maciej Zacharski, Alicja Tomaszek, Katarzyna Michlik
BACKGROUND: The adverse effects of oxidative stress and the presence of proinflammatory factors in the heart have been widely demonstrated mainly on rodent models. However, larger clinical trials focusing on inflammation or oxidative stress in heart failure (HF) have not been carried out. This may be due to differences in the anatomy and physiology of the cardiovascular system between small rodents and large mammals. Thus, we investigated myocardial inflammatory factors, such as inducible NO synthase (iNOS) and oxidative stress indices in female pigs with chronic tachycardia-induced cardiomyopathy...
January 2016: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
Yan-ling Wang, Jing-hui Chen, Qiong-fang Zhu, Gao-feng Yu, Chen-fang Luo, Gang-jian Luo, Shang-rong Li, Zi-qing Hei
Acute kidney injury associated with renal hypoperfusion is a frequent and severe complication during sepsis. Fluid resuscitation is the main therapy. However, heart failure is usually lethal for those patients receiving large volumes of fluids. We compared the effects of small-volume resuscitation using four different treatment regimens, involving saline, hypertonic saline (HTS), hydroxyethyl starch (HES), or hypertonic saline hydroxyethyl starch (HSH), on the kidneys of rats treated with lipopolysaccharide (LPS) to induce endotoxemia...
2015: Mediators of Inflammation
Sandhya Metta, Doddamani R Basalingappa, Satyanarayana Uppala, Geeta Mitta
BACKGROUND: Cigarette smoke promotes atherogenesis by producing oxygen-derived free radicals. AIM: The present study was conducted to determine the effect of cigarette smoking on lipid peroxidation and erythrocyte antioxidant status in ischemic heart disease (IHD). MATERIALS AND METHODS: A total of 327 male subjects were enrolled for this study, divided into two groups consisting of 200 patients, who were consecutively admitted for IHD in the intensive cardiac care unit (ICCU) of a Government Hospital and 127 age matched male healthy subjects...
June 2015: Journal of Clinical and Diagnostic Research: JCDR
Alberto Roghi, Erika Poggiali, Lorena Duca, Antonio Mafrici, Patrizia Pedrotti, Stefania Paccagnini, Sergio Brenna, Alessio Galli, Dario Consonni, Maria Domenica Cappellini
BACKGROUND: Hereditary hemochromatosis, thalassemia and myelodysplastic syndromes represent disease models with evidence of iron-related heart failure. Non-Transferrin Bound Iron (NTBI) induces cardiac toxicity through the production of reactive oxygen species and lipid peroxidation. In ST-elevation acute myocardial infarction (STEMI) with evidence of microvascular obstruction (MVO) and hemorrhage (HEM), HEM may be a source of iron-related cardiac toxicity through NTBI and pro-inflammatory mediators...
November 15, 2015: International Journal of Cardiology
Peng Zhao, Ru Zhou, Xiao-Yun Zhu, Yin-Ju Hao, Nan Li, Jie Wang, Yang Niu, Tao Sun, Yu-Xiang Li, Jian-Qiang Yu
Matrine, an active constituent of the Chinese herb, Sophora flavescens Ait., and it is known for its antioxidant, anti-inflammatory and antitumor activities. It has been demonstrated that matrine exerts protective effects against heart failure by decreasing the expression of caspase-3 and Bax, and increasing Bcl‑2 levels. In this study, we aimed to determine whether these protective effects of matrine can be applied to cerebral ischemia. Following 7 successive days of treatment with matrine (7.5, 15 and 30 mg/kg) and nimodipine (1 mg/kg) by intraperitoneal injection, male Institute of Cancer Research (ICR) mice were subjected to middle cerebral artery occlusion (MCAO)...
September 2015: International Journal of Molecular Medicine
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