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malondialdehyde in heart failure

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https://www.readbyqxmd.com/read/27928616/oleuropein-attenuates-the-progression-of-heart-failure-in-rats-by-antioxidant-and-antiinflammatory-effects
#1
Zeinab Janahmadi, Ali Akbar Nekooeian, Ali Reza Moaref, Masoomeh Emamghoreishi
Much of the beneficial effects of olive products have been attributed to oleuropein. This study examined the effects of oleuropein in rats with heart failure induced by permanent ligation of left coronary arteries. Twenty-four hours after the operation, the rats were assigned to five groups including a sham assigned to receive vehicle (1 ml/day) and four coronary ligated groups assigned to receive vehicle or oleuropein at 5, 10, or 20 mg/kg/day. Five weeks later, echocardiographic and hemodynamic parameters, serum concentrations of oxidative stress, and inflammatory markers were determined...
December 8, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27924631/cardioprotective-effects-of-curcumin-loaded-magnetic-hydrogel-nanocomposite-nanocurcumin-against-doxorubicin-induced-cardiac-toxicity-in-rat-cardiomyocyte-cell-lines
#2
Mehrdad Namdari, Ali Eatemadi
Curcumin, is a yellow substance extracted from Curcuma longa rhizomes, it is a crystalline compound that has been traditionally applied in culinary practices and medicines in India. The aim of our study is to demonstrate the efficacy of curcumin-loaded magnetic hydrogel nanocomposite in the treatment of heart hypertrophy. 10 rats weighing 150-200 g each were induced with heart failure using 2.5 mg/kg doxorubicin for 2 weeks. The test groups were treated with curcumin-loaded magnetic hydrogel nanocomposite while the control was treated with curcumin alone...
December 7, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27862262/different-effects-of-selective-%C3%AE-1-adrenoceptor-antagonists-nebivolol-or-atenolol-in-acetaminophen-induced-heptatotoxicity-of-rats
#3
Remon R Rofaeil, Maha Yehia Kamel, Walaa Yehia Abdelzaher
Acetaminophen (APAP) overdose is a common cause of acute liver failure and beta blockers are commonly used drugs in clinical practice. This study aims to evaluate the effect of two different beta blockers agents as nebivolol and atenolol against APAP-induced hepatotoxicity. Male wistar rats were treated with APAP (2 g/kg/day, p.o.) to induce hepatotoxicity. Our results showed that nebivolol and atenolol reduced heart rate and blood pressure. Nebivolol (5 mg/kg /day, p.o.) for 14 days has a hepatoprotective effect shown by significant decrease in hepatic injury parameters (serum AST and ALT) with significant suppression of hepatic malondialdehyde (MDA) and nitric oxide (NO) which were elevated with APAP administration...
November 14, 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27818481/effect-of-allopurinol-on-myocardial-energy-metabolism-in-chronic-heart-failure-rats-after-myocardial-infarct
#4
Zhenzhen Wang, Juan Ding, Xiang Luo, Siliang Zhang, Gang Yang, Que Zhu, Dichuan Liu
To determine the effect of the xanthine oxidase (XO) inhibitor allopurinol on myocardial energy metabolism in a chronic heart failure rat model after myocardial infarct.An AMI model was established in 6-week-old rats via the ligation of the anterior descending coronary artery. Thirty-five rats were randomly divided into the following 3 groups: an ALLO group, an AMI group, and a Sham group. Heart failure was successfully diagnosed via echocardiography and blood tests. Xanthine oxidase (XO), malondialdehyde (MDA), PGC-1α, CPT-1, and GLUT4 were monitored in the myocardium...
November 4, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27624556/nox2-amplifies-acetaldehyde-mediated-cardiomyocyte-mitochondrial-dysfunction-in-alcoholic-cardiomyopathy
#5
Moritz Brandt, Venkata Garlapati, Matthias Oelze, Efthymios Sotiriou, Maike Knorr, Swenja Kröller-Schön, Sabine Kossmann, Tanja Schönfelder, Henning Morawietz, Eberhard Schulz, Heinz-Peter Schultheiss, Andreas Daiber, Thomas Münzel, Philip Wenzel
Alcoholic cardiomyopathy (ACM) resulting from excess alcohol consumption is an important cause of heart failure (HF). Although it is assumed that the cardiotoxicity of the ethanol (EtOH)-metabolite acetaldehyde (ACA) is central for its development and progression, the exact mechanisms remain obscure. Murine cardiomyocytes (CMs) exposed to ACA or EtOH showed increased superoxide (O2(•-)) levels and decreased mitochondrial polarization, both being normalized by NADPH oxidase (NOX) inhibition. C57BL/6 mice and mice deficient for the ACA-degrading enzyme mitochondrial aldehyde dehydrogenase (ALDH-2(-/-)) were fed a 2% EtOH diet for 5 weeks creating an ACA-overload...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27581176/impact-of-malondialdehyde-modified-low-density-lipoprotein-on-tissue-characteristics-in-patients-with-stable-coronary-artery-disease%C3%A3-integrated-backscatter-intravascular-ultrasound-study
#6
Hiroki Ikenaga, Satoshi Kurisu, Shingo Kono, Yoji Sumimoto, Noriaki Watanabe, Takashi Shimonaga, Tadanao Higaki, Toshitaka Iwasaki, Naoya Mitsuba, Ken Ishibashi, Yoshihiro Dohi, Yukihiro Fukuda, Yasuki Kihara
BACKGROUND: Malondialdehyde-modified low-density lipoprotein (MDA-LDL) is considered to play an essential role in plaque destabilization. We aimed to investigate the association between the tissue characteristics of culprit plaque assessed by integrated backscatter (IB)-intravascular ultrasound (IVUS) and the serum MDA-LDL levels in patients with stable coronary artery disease. METHODS AND RESULTS: The study group consisted of 179 patients undergoing IB-IVUS during elective percutaneous coronary intervention...
September 23, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27473036/nitrite-therapy-ameliorates-myocardial-dysfunction-via-h2s-and-nuclear-factor-erythroid-2-related-factor-2-nrf2-dependent-signaling-in-chronic-heart-failure
#7
Erminia Donnarumma, Shashi Bhushan, Jessica M Bradley, Hiroyuki Otsuka, Erinn L Donnelly, David J Lefer, Kazi N Islam
BACKGROUND: Bioavailability of nitric oxide (NO) and hydrogen sulfide (H2S) is reduced in heart failure (HF). Recent studies suggest cross-talk between NO and H2S signaling. We previously reported that sodium nitrite (NaNO2) ameliorates myocardial ischemia-reperfusion injury and HF. Nuclear factor-erythroid-2-related factor 2 (Nrf2) regulates the antioxidant proteins expression and is upregulated by H2S. We examined the NaNO2 effects on endogenous H2S bioavailability and Nrf2 activation in mice subjected to ischemia-induced chronic heart failure (CHF)...
2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27351177/modulation-of-mapk-and-nf-954-b-signaling-pathways-by-antioxidant-therapy-in-skeletal-muscle-of-heart-failure-rats
#8
Paula F Martinez, Camila Bonomo, Daniele M Guizoni, Silvio A Oliveira Junior, Ricardo L Damatto, Marcelo D M Cezar, Aline R R Lima, Luana U Pagan, Fabio R Seiva, Renata T Bueno, Denise C Fernandes, Francisco R Laurindo, Leonardo A M Zornoff, Katashi Okoshi, Marina P Okoshi
BACKGROUND/AIMS: Although increased oxidative stress plays a role in heart failure (HF)-induced skeletal myopathy, signaling pathways involved in muscle changes and the role of antioxidant agents have been poorly addressed. We evaluated the effects of N-acetylcysteine (NAC) on intracellular signaling pathways potentially modulated by oxidative stress in soleus muscle from HF rats. METHODS AND RESULTS: Four months after surgery, rats were assigned to Sham, myocardial infarction (MI)-C (without treatment), and MI-NAC (treated with N-acetylcysteine) groups...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27097156/the-effects-of-ultrafiltration-and-diuretic-therapies-on-oxidative-stress-markers-in-patients-with-cardio-renal-syndrome
#9
Tansu Sav, Faruk Cecen, Enver S Albayrka
BACKGROUND: Cardiorenal syndrome (CRS) is defined as complex pathophysiological disorder of the heart and kidneys. Both heart and renal failure are characterized by increased systemic oxidative stress in CRS. The aim of the present study is to assess the impacts of ultrafiltration (UF) and furosemide treatment on oxidative stress markers and renal functions in patients with CRS. METHOD: 77 patients with CRS (37 patients in the UF group and 40 patients in the furosemide group) were included in the study...
April 20, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27073402/protective-effects-of-sheng-mai-san-on-right-ventricular-dysfunction-during-chronic-intermittent-hypoxia-in-mice
#10
Cheng-Zhi Chai, Wei-Lan Mo, Xian-Fei Zhuang, Jun-Ping Kou, Yong-Qing Yan, Bo-Yang Yu
Right ventricular (RV) dysfunction and failure contribute to the increasing morbidity and mortality of cardiovascular diseases; however, current treatment strategies are grossly inadequate. Sheng-Mai-San (SMS) has been used to treat heart diseases for hundreds of years in China, and its protective effects on RV have not been observed. The present study was to investigate the protective effects of SMS aqueous extract on RV dysfunction in chronic intermittent hypoxia (CIH) mice model. The results showed that CIH mice model presented RV dysfunction and maladaptive compensation after 28-day-CIH and SMS treatment significantly reversed these changes...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/26863032/delayed-treatment-with-sodium-hydrosulfide-improves-regional-blood-flow-and-alleviates-cecal-ligation-and-puncture-clp-induced-septic-shock
#11
Akbar Ahmad, Nadiya Druzhyna, Csaba Szabo
Cecal ligation and puncture (CLP)-induced sepsis is a serious medical condition, caused by a severe systemic infection resulting in a systemic inflammatory response. Recent studies have suggested the therapeutic potential of donors of hydrogen sulfide (H2S), a novel endogenous gasotransmitter and biological mediator in various diseases. The aim of the present study was to assess the effect of H2S supplementation in sepsis, with special reference to its effect on the modulation of regional blood flow. We infused sodium hydrosulfide (NaHS), a compound that produces H2S in aqueous solution (1, 3, or 10 mg/kg/h, for 1 h at each dose level) in control rats or rats 24 h after CLP, and measured blood flow using fluorescent microspheres...
August 2016: Shock
https://www.readbyqxmd.com/read/26846272/berberine-pretreatment-confers-cardioprotection-against-ischemia-reperfusion-injury-in-a-rat-model-of-type-2-diabetes
#12
Wenguang Chang, Kun Li, Fengying Guan, Fan Yao, Yang Yu, Ming Zhang, Grant M Hatch, Li Chen
Preclinical and clinical studies have demonstrated that berberine (BBR) improves diabetic complications and reduces mortality of patients with congestive heart failure. The therapeutic effects of BBR have been reported to be mediated by its regulation of adenosine monophosphate (AMP)-activated protein kinase (AMPK). We previously reported that BBR protects against ischemia-reperfusion injury via regulating AMPK activity in both ischemic and nonischemic areas of the rat heart. Since diabetic hearts are more sensitive to ischemia-reperfusion injury, we examined whether BBR treatment exhibited cardioprotective effects in the diabetic heart...
September 2016: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/26833169/reduction-of-acute-lung-injury-by-administration-of-spironolactone-after-intestinal-ischemia-and-reperfusion-in-rats
#13
Figen Barut, V Haktan Ozacmak, Inci Turan, Hale Sayan-Ozacmak, Erol Aktunc
PURPOSE: Multiple organ failure, including acute lung injury, is a common complication of intestinal ischemia and reperfusion (I/R) injury and contributes to its high mortality rate. Activated polymorphonuclear neutrophils and reactive oxygen species contribute to the lung injury caused by intestinal I/R. Mineralocorticoid receptor antagonist spironolactone has a protective effect against I/R injury in animal models of retina, kidney, heart, and brain. The aim of the present study is to investigate the effect of aldosterone receptor blocker spironolactone on lung injury induced by intestinal I/R...
February 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/26664452/protective-effects-of-salidroside-on-mitochondrial-functions-against-exertional-heat-stroke-induced-organ-damage-in-the-rat
#14
Wei Zhang, Ming Peng, Yang Yang, Zhangwu Xiao, Bin Song, Zhaofen Lin
Exertional heat stroke (EHS) results in a constellation of systemic inflammatory responses resulting in multiorgan failure and an extremely high mortality. The present study was designed to evaluate the protective effects of salidroside on EHS by improving mitochondrial functions in the rat model. Liver and heart mitochondria were observed by transmission electron microscopy and mitochondrial membrane potential (ΔΨm) was detected by a fluorescent probe. Intramitochondrial free Ca(2+) concentration, mitochondrial respiratory control ratio (RCR), reactive oxygen species (ROS) levels, superoxide dismutase (SOD), and malondialdehyde (MDA) activity were detected by the corresponding kits...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/26647638/pharmacodynamical-evaluation-of-matrix-type-transdermal-therapeutic-systems-containing-captopril
#15
Oya Kerımoğlu, Sevınç Şahbaz, Özer Şehırlı, Zarıfe Nıgar Ozdemır, Şule Çetınel, Betül Dortunç, Göksel Şener
The objective of this study was to evaluate pharmacodynamical properties of transdermal therapeutic systems (TTS) containing captopril together with synthetic and pH independent polymers, Eudragit RL 100 and RS 100. Optimum formulation was chosen according to the results of our previous study regarding in vitro dissolution and ex vivo diffusion rate studies through excised human skin by using Franz Diffusion Cell. Control group, hypertension group (HT) and TTS containing captopril hypertension group (HT-CAP) were assessed for the pharmacodynamic activity of the study...
July 2015: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/26635633/methylprednisolone-protects-cardiac-pumping-mechanics-from-deteriorating-in-lipopolysaccharide-treated-rats
#16
Ya-Hui Ko, Ming-Shian Tsai, Ru-Wen Chang, Chun-Yi Chang, Chih-Hsien Wang, Ming-Shiou Wu, Jin-Tung Liang, Kuo-Chu Chang
It has been shown that a prolonged low-dose corticosteroid treatment attenuates the severity of inflammation and the intensity and duration of organ system failure. In the present study, we determined whether low-dose methylprednisolone (a synthetic glucocorticoid) can protect male Wistar rats against cardiac pumping defects caused by lipopolysaccharide-induced chronic inflammation. For the induction of chronic inflammation, a slow-release ALZET osmotic pump was subcutaneously implanted to infuse lipopolysaccharide (1 mg kg(-1) d(-1)) for 2 weeks...
2015: Frontiers in Physiology
https://www.readbyqxmd.com/read/26539521/myeloperoxidase-related-chlorination-activity-is-positively-associated-with-circulating-ceruloplasmin-in-chronic-heart-failure-patients-relationship-with-neurohormonal-inflammatory-and-nutritional-parameters
#17
Aderville Cabassi, Simone Maurizio Binno, Stefano Tedeschi, Gallia Graiani, Cinzia Galizia, Michele Bianconcini, Pietro Coghi, Federica Fellini, Livia Ruffini, Paolo Govoni, Massimo Piepoli, Stefano Perlini, Giuseppe Regolisti, Enrico Fiaccadori
RATIONALE: Heart failure (HF) is accompanied by the development of an imbalance between oxygen- and nitric oxide-derived free radical production leading to protein nitration. Both chlorinating and peroxidase cycle of Myeloperoxidase (MPO) contribute to oxidative and nitrosative stress and are involved in tyrosine nitration of protein. Ceruloplasmin (Cp) has antioxidant function through its ferroxidase I (FeOxI) activity and has recently been proposed as a physiological defense mechanism against MPO inappropriate actions...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26508994/oxidative-stress-in-dilated-cardiomyopathy-caused-by-mybpc3-mutation
#18
Thomas L Lynch, Mayandi Sivaguru, Murugesan Velayutham, Arturo J Cardounel, Michelle Michels, David Barefield, Suresh Govindan, Cristobal dos Remedios, Jolanda van der Velden, Sakthivel Sadayappan
Cardiomyopathies can result from mutations in genes encoding sarcomere proteins including MYBPC3, which encodes cardiac myosin binding protein-C (cMyBP-C). However, whether oxidative stress is augmented due to contractile dysfunction and cardiomyocyte damage in MYBPC3-mutated cardiomyopathies has not been elucidated. To determine whether oxidative stress markers were elevated in MYBPC3-mutated cardiomyopathies, a previously characterized 3-month-old mouse model of dilated cardiomyopathy (DCM) expressing a homozygous MYBPC3 mutation (cMyBP-C((t/t))) was used, compared to wild-type (WT) mice...
2015: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/26416627/systemic-inflammatory-response-syndrome-in-end-stage-heart-failure-patients-following-continuous-flow-left-ventricular-assist-device-implantation-differences-in-plasma-redox-status-and-leukocyte-activation
#19
Nandan K Mondal, Erik N Sorensen, Si M Pham, Steven C Koenig, Bartley P Griffith, Mark S Slaughter, Zhongjun J Wu
The role of oxidative stress and leukocyte activation has not been elucidated in developing systemic inflammatory response syndrome (SIRS) in heart failure (HF) patients after continuous-flow left ventricular assist device (CF-LVAD) implantation. The objective of this study was to investigate the change of plasma redox status and leukocyte activation in CF-LVAD implanted HF patients with or without SIRS. We recruited 31 CF-LVAD implanted HF patients (16 SIRS and 15 non-SIRS) and 11 healthy volunteers as the control...
May 2016: Artificial Organs
https://www.readbyqxmd.com/read/26361649/inducible-no-synthase-is-constitutively-expressed-in-porcine-myocardium-and-its-level-decreases-along-with-tachycardia-induced-heart-failure
#20
Urszula Paslawska, Liliana Kiczak, Jacek Bania, Robert Paslawski, Adrian Janiszewski, Piotr Dzięgiel, Maciej Zacharski, Alicja Tomaszek, Katarzyna Michlik
BACKGROUND: The adverse effects of oxidative stress and the presence of proinflammatory factors in the heart have been widely demonstrated mainly on rodent models. However, larger clinical trials focusing on inflammation or oxidative stress in heart failure (HF) have not been carried out. This may be due to differences in the anatomy and physiology of the cardiovascular system between small rodents and large mammals. Thus, we investigated myocardial inflammatory factors, such as inducible NO synthase (iNOS) and oxidative stress indices in female pigs with chronic tachycardia-induced cardiomyopathy...
January 2016: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
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