keyword
https://read.qxmd.com/read/38517365/phoenixin-20-ameliorates-pulmonary-arterial-hypertension-via-inhibiting-inflammation-and-oxidative-stress
#1
JOURNAL ARTICLE
Yaqin Chai, Xing Gu, HongJun Zhang, Xinting Xu, Lizhan Chen
Pulmonary arterial hypertension (PAH) is a severe pathophysiological syndrome resulting in heart failure, which is found to be induced by pulmonary vascular remodeling mediated by oxidative stress (OS) and inflammation. Phoenixin-20 (PNX-20) is a reproductive peptide first discovered in mice with potential suppressive properties against OS and inflammatory response. Our study will explore the possible therapeutic functions of PHN-20 against PAH for future clinical application. Rats were treated with normal saline, PHN-20 (100 ng/g body weight daily), hypoxia, hypoxia+PHN-20 (100 ng/g body weight daily), respectively...
March 19, 2024: Aging
https://read.qxmd.com/read/38417368/diannexin-alleviates-myocardial-ischemia-reperfusion-injury-by-orchestrating-cardiomyocyte-oxidative-damage-macrophage-polarization-and-fibrotic-process-by-tlr4-nf-kb-mediated-inactivation-of-nlrp3-inflammasome
#2
JOURNAL ARTICLE
Lin Zhang, Songlin Zhao, Yaqi Wang
Myocardial ischemia-reperfusion (I/R) injury is a pathogenic mechanism of myocardial infarction and heart failure, constituting a major health concern globally. Diannexin is a homodimer of recombinant human annexin V and elicits important roles in several I/R injuries. Nevertheless, its function in MI/R remains elusive. Here, Diannexin alleviated simulated I/R (SI/R)-induced cardiomyocyte death and oxidative injury by increasing cell viability and inhibiting cell apoptosis, ROS, lactate dehydrogenase, malondialdehyde production and anti-oxidative SOD activity...
February 27, 2024: International Immunopharmacology
https://read.qxmd.com/read/38385181/statin-administration-improves-vascular-function-in-heart-failure-with-preserved-ejection-fraction
#3
JOURNAL ARTICLE
Jarred J Iacovelli, Jeremy K Alpenglow, Stephen M Ratchford, Jesse C Craig, Jonah M Simmons, Jia Zhao, Van Reese, Kanokwan Bunsawat, Christy L Ma, John J Ryan, D Walter Wray
Heart failure with preserved ejection fraction (HFpEF) is characterized by impaired vascular endothelial function that may be improved by hydroxy-methylglutaryl-CoA (HMG-CoA) reductase enzyme inhibition. Thus, using a parallel, double-blind, placebo-controlled design, this study evaluated the efficacy of 30-day atorvastatin administration (10mg QD) on peripheral vascular function and biomarkers of inflammation and oxidative stress in sixteen patients with HFpEF (Statin: n=8, 74±6 yr, EF 52-73%; Placebo: n=8, 67±9 yr, EF 56-72%)...
February 22, 2024: Journal of Applied Physiology
https://read.qxmd.com/read/38334825/vitamin-d-ameliorates-celecoxib-cardiotoxicity-in-a-doxorubicin-heart-failure-rat-model-via-enhancement-of-the-antioxidant-defense-and-minimizing-mitochondrial-dysfunction
#4
JOURNAL ARTICLE
Sepideh Azizian, Saleh Khezri, Mohammad Shabani, Saman Atashbar, Ahmad Salimi
Recent evidence suggests the mechanistic role of mitochondria and oxidative stress in the development of celecoxib-induced cardiotoxicity. On the other, it has reported the positive effects of vitamin D on oxidative stress and the maintenance of mitochondrial functions. This current study examined the cardiac effects of celecoxib, doxorubicin, vitamin D, and a combination of them in rats. The effect of 10 days of celecoxib (100 mg/kg/day), doxorubicin (2.5 mg/kg), vitamin D (60,000 U/kg), and their combination was studied on cardiac function according to serum lactate dehydrogenase (LDH), creatine kinase (CK), glutathione (GSH), and malondialdehyde (MDA) levels as well as mitochondrial succinate dehydrogenases (SDH) activity, reactive oxygen species (ROS) production, mitochondrial swelling, and mitochondrial membrane potential (MMP)...
February 9, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38305401/the-different-therapeutic-effects-of-traditional-chinese-medicine-shensong-yangxin-capsule-and-salubrinal-in-high-intensity-exercise-induced-heart-failure-in-rats-with-acute-myocardial-infarction
#5
JOURNAL ARTICLE
Junli Lu, Yanzhuo Ma, Hongzhi Lv, Congxin Li, Leisheng Ru, Jian Zhao, Dongmei Wang
BACKGROUND: Currently, endoplasmic reticulum stress is studied utilizing a dephosphorylation inhibitor (Sal). The traditional Chinese patent medicine and simple formulation Shensong Yangxin Capsule is a commonly used medication for the treatment of arrhythmia. However, the efficacy and underlying mechanism of the capsule in treating post-ischemic heart failure in myocardial tissue have not yet been investigated. OBJECTIVE: The therapeutic effects and the underlying mechanism of the Shensong Yangxin Capsule (SSYX) and the dephosphorylation inhibitor Salubrinal (Sal) on heart failure (HF) induced by high-intensity exercise in rats with acute myocardial infarction (AMI) were investigated...
January 15, 2024: Combinatorial Chemistry & High Throughput Screening
https://read.qxmd.com/read/38247327/arginine-vasopressin-induces-ferroptosis-to-promote-heart-failure-via-activation-of-the-v1ar-can-nfatc3-pathway
#6
JOURNAL ARTICLE
Zhiyong Wu, Hua Jiang, Qiulin Yin, Zhifeng Zhang, Xuanlan Chen
Arginine vasopressin (AVP) is a key contributor to heart failure (HF), but the underlying mechanisms remain unclear. In the present study, a mouse model of HF and human cardiomyocyte (HCM) cells treated with dDAVP are generated in vivo and in vitro , respectively. Hematoxylin and eosin (HE) staining is used to evaluate the morphological changes in the myocardial tissues. A colorimetric method is used to measure the iron concentration, Fe 2+ concentration and malondialdehyde (MDA) level. Western blot analysis is used to examine the protein levels of the V1a receptor (V1aR), calcineurin (CaN), nuclear factor of activated T cells isoform C3 (NFATC3), glutathione peroxidase 4 (GPX4) and acyl-CoA synthase long chain family member 4 (ACSL4)...
January 22, 2024: Acta Biochimica et Biophysica Sinica
https://read.qxmd.com/read/38178352/a-retrospective-clinical-study-on-cardiovascular-complications-from-colorectal-cancer
#7
JOURNAL ARTICLE
Ting Yin, Jianqi Yang, Xiaojing Liu, Jiaqi Huang, Erxun Dai
OBJECTIVE: To investigate the incidence and risk factors of cardiovascular complications amongst patients with colorectal cancer (CRC). METHODS: A retrospective cohort study was conducted on 2085 patients diagnosed with CRC in two tertiary hospitals in China between 2015 and 2020. The patients' medical records were reviewed to identify cardiovascular complications, including myocardial infarction, heart failure, stroke, hypertension, coronary heart disease, heart failure, and arrhythmia...
December 26, 2023: Heart Surgery Forum
https://read.qxmd.com/read/38136887/differences-in-levels-of-mitochondrial-dna-content-at-various-stages-of-canine-myxomatous-mitral-valve-disease
#8
JOURNAL ARTICLE
Suphakan Chirathanaphirom, Phongsakorn Chuammitri, Wanpitak Pongkan, Nawin Manachai, Pinkarn Chantawong, Burin Boonsri, Chavalit Boonyapakorn
Myxomatous mitral valve disease (MMVD) is the most common heart disease in small-breed dogs, often leading to heart failure. Oxidative stress in MMVD can harm mitochondria, decreasing their DNA content. This study assesses dogs' oxidative stress and mitochondrial DNA at different MMVD stages. Fifty-five small-breed dogs were categorized into four groups, including: A-healthy ( n = 15); B-subclinical ( n = 15); C-heart failure ( n = 15); and D-end-stage MMVD ( n = 10). Serum malondialdehyde (MDA) and mitochondrial DNA in peripheral blood were analyzed...
December 14, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38125366/echinacoside-ameliorates-doxorubicin%C3%A2-induced-cardiac-injury-by-regulating-gpx4-inhibition%C3%A2-induced-ferroptosis
#9
JOURNAL ARTICLE
Yan Ma, Xiaoli Yang, Nianxin Jiang, Cheng Lu, Jiehan Zhang, Shaowei Zhuang
Echinacoside (ECH) is a compound derived from the natural herbs Cistanche and Echinacea , which has considerable protective effects on heart failure (HF). HF is characterized by myocardial damage and abnormal ferroptosis. Glutathione peroxidase 4 (GPX4) is an important regulator of ferroptosis, which plays a role in ferroptosis-related diseases. Despite this, the therapeutic mechanisms of ECH against HF remain unknown. Therefore, the aim of the present study was to investigate the cardioprotective effect and underlying mechanisms of ECH in the treatment of doxorubicin (DOX)-induced chronic HF (CHF)...
January 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38114118/-pathogenesis-of-chronic-heart-failure-in-rats-based-on-ferroptosis-mediated-oxidative-stress-and-intervention-effect-of-shenfu-injection
#10
JOURNAL ARTICLE
Zi-Yi Wang, Qian Zhang, Jin Guo, Shu-Min Huang, Li-Chong Meng, Zhi-Xi Hu
This study aims to investigate the pathogenesis of chronic heart failure based on ferroptosis-mediated oxidative stress and predict the targets of Shenfu Injection in treating chronic heart failure. A rat model of chronic heart failure was established by the isoproterenol induction method. According to the random number table method, the modeled rats were assigned into three groups: a model group, a Shenfu Injection group, and a ferrostatin-1(ferroptosis inhibitor) group. In addition, a normal group was designed...
October 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38004420/stable-gastric-pentadecapeptide-bpc-157-therapy-effect-on-reperfusion-following-maintained-intra-abdominal-hypertension-grade-iii-and-iv-in-rats
#11
JOURNAL ARTICLE
Marijan Tepes, Ivan Krezic, Hrvoje Vranes, Ivan Maria Smoday, Luka Kalogjera, Helena Zizek, Vlasta Vukovic, Katarina Oroz, Katarina Kasnik Kovac, Zrinko Madzar, Mislav Rakic, Blazenka Miskic, Suncana Sikiric, Ivan Barisic, Sanja Strbe, Marko Antunovic, Luka Novosel, Ivana Kavelj, Josipa Vlainic, Ivan Dobric, Mario Staresinic, Anita Skrtic, Sven Seiwerth, Alenka Boban Blagaic, Predrag Sikiric
Given in reperfusion, the use of stable gastric pentadecapeptide BPC 157 is an effective therapy in rats. It strongly counteracted, as a whole, decompression/reperfusion-induced occlusion/occlusion-like syndrome following the worst circumstances of acute abdominal compartment and intra-abdominal hypertension, grade III and grade IV, as well as compression/ischemia-occlusion/occlusion-like syndrome. Before decompression (calvariectomy, laparotomy), rats had long-lasting severe intra-abdominal hypertension, grade III (25 mmHg/60 min) (i) and grade IV (30 mmHg/30 min; 40 mmHg/30 min) (ii/iii), and severe occlusion/occlusion-like syndrome...
November 2, 2023: Pharmaceuticals
https://read.qxmd.com/read/37957697/treatment-with-recombinant-sirt1-rewires-the-cardiac-lipidome-and-rescues-diabetes-related-metabolic-cardiomyopathy
#12
JOURNAL ARTICLE
Sarah Costantino, Alessandro Mengozzi, Srividya Velagapudi, Shafeeq Ahmed Mohammed, Era Gorica, Alexander Akhmedov, Alessia Mongelli, Nicola Riccardo Pugliese, Stefano Masi, Agostino Virdis, Andreas Hülsmeier, Christian Matthias Matter, Thorsten Hornemann, Giovanni Melina, Frank Ruschitzka, Thomas Felix Luscher, Francesco Paneni
BACKGROUND: Metabolic cardiomyopathy (MCM), characterized by intramyocardial lipid accumulation, drives the progression to heart failure with preserved ejection fraction (HFpEF). Although evidence suggests that the mammalian silent information regulator 1 (Sirt1) orchestrates myocardial lipid metabolism, it is unknown whether its exogenous administration could avoid MCM onset. We investigated whether chronic treatment with recombinant Sirt1 (rSirt1) could halt MCM progression. METHODS: db/db mice, an established model of MCM, were supplemented with intraperitoneal rSirt1 or vehicle for 4 weeks and compared with their db/ + heterozygous littermates...
November 13, 2023: Cardiovascular Diabetology
https://read.qxmd.com/read/37871668/deubiquitinase-otub1-regulates-doxorubicin-induced-cardiotoxicity-via-deubiquitinating-c-myc
#13
JOURNAL ARTICLE
Fei Xu, Tongtong Zang, Han Chen, Changyi Zhou, Rui Wang, Yue Yu, Li Shen, Juying Qian, Junbo Ge
BACKGROUND: Doxorubicin (DOX), an anthracycline drug widely used in antitumor therapies, has dose-dependent toxicity that can cause cardiomyocyte apoptosis and oxidative stress, thus limiting its clinical application. OTUB1 (ovarian tumor associated proteinase B1) is an OTU superfamily deubiquitinase that effectively regulates cell proliferation, inflammatory responses, apoptosis, and oxidative stress by specifically removing K48- and K63-linked ubiquitination; however, its role in DOX-induced cardiotoxicity remains unknown...
October 21, 2023: Cellular Signalling
https://read.qxmd.com/read/37816240/effect-of-metformin-on-oxidative-stress-and-left-ventricular-geometry-in-nondiabetic-heart-failure-patients-a-randomized-controlled-trial
#14
JOURNAL ARTICLE
Ahmed M Kamel, Batool Ismail, Gamal Abdel Hafiz, Nirmeen Sabry, Samar Farid
Introduction: There is an increasing interest in using metformin in cardiovascular diseases and its potential new roles. Only two randomized controlled trials investigated the effect of metformin in nondiabetic heart failure (HF) patients. However, none of these studies assess the role of metformin in reducing oxidative stress. We hypothesized that metformin might improve oxidative stress and left ventricular remodeling in nondiabetic HF patients with reduced ejection fraction (HFrEF). Methods and Methods: Seventy HFrEF patients (EF 37% ± 8%; median age 66 years) were randomized to metformin ( n  = 35) or standard of care (SOC) for HF ( n  = 35) for 6 months in addition to standard therapy...
October 10, 2023: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/37778994/catalpol-inhibits-autophagy-to-ameliorate-doxorubicin-induced-cardiotoxicity-via-the-akt-mtor-pathway
#15
JOURNAL ARTICLE
Bo Liu, Han Xie, Xiongbing Du, Yuyang Zhou, Jiashun Huang
As a kind of anthracycline, doxorubicin (DOX) is commonly used as an antitumor drug, but its clinical application has been greatly hindered due to its severe cardiotoxicity. Hence, in this study, we investigated the role of catalpol (CTP) and its effect on DOX-induced cardiotoxicity.The cardiac function of mice was evaluated by assessing lactate dehydrogenase, creatine kinase isoenzyme, heart weight to body weight, and heart weight/tibia length levels. Histopathological changes were observed using hematoxylin and eosin staining, and the terminal deoxynucleotidyl transferase dUTP nick end labeling assay was used to examine myocardial apoptosis...
2023: International Heart Journal
https://read.qxmd.com/read/37759971/malondialdehyde-serum-levels-in-patients-with-systemic-sclerosis-relate-to-dyslipidemia-and-low-ventricular-ejection-fraction
#16
JOURNAL ARTICLE
Zeina Ibrahim-Achi, Pablo Jorge-Pérez, Pedro Abreu-González, Raquel López-Mejías, Candelaria Martín-González, Miguel Á González-Gay, Iván Ferraz-Amaro
Systemic sclerosis (SSc) is a chronic disease characterized by vasculopathy with the involvement of dysfunctional microcirculatory vessels. Features of the disease include progressive fibrosis of the skin and internal organs and systemic inflammation characterized by the presence of circulating autoantibodies and proinflammatory cytokines. Furthermore, macrovascular disease and atherosclerosis are more common in patients with SSc than in the general population. Oxidative stress plays a crucial role in the development of several processes, including endothelial dysfunction, cancer, inflammation, and atherogenesis...
August 25, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/37728183/beta-vulgaris-derived-exosome-like-nanovesicles-alleviate-chronic-doxorubicin-induced-cardiotoxicity-by-inhibiting-ferroptosis
#17
JOURNAL ARTICLE
Jiejie Cai, Jingye Pan
Dose-dependent heart failure is a major complication of the clinical use of doxorubicin (Dox), one of the most potent chemotherapeutic agents. Effective adjuvant therapy is required to prevent Dox-induced cardiotoxicity. Currently, plant-derived exosome-like nanovesicle (PELNV) has revealed their salubrious antioxidant and immunological regulating actions in various disease models. In this study, we isolated, purified and characterized Beta vulgaris-derived exosome-like nanovesicle (BELNV). Dox or normal saline was given to HL-1 cells (3 μM) and 8-week C57BL/6N mice (5 mg/kg bodyweight per week for 4 weeks) to establish the in vitro and in vivo model of Dox-induced cardiotoxicity...
September 20, 2023: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/37701944/protective-effect-of-vitamin-b-6-against-doxorubicin-induced-cardiotoxicity-by-modulating-nhe1-expression
#18
JOURNAL ARTICLE
Rui-Li Sun, Huan-Huan Wang, Zi-Chen Gui, Shuang-Guo, Lai-Biao Lin, Jia-Xin Fan, Xue-Zhang, Bin-Yan Mao, Geng Liu, Wei-Zhen Liu, Rui-Zhu Yue, Ya-Ling Yin, Qian-Qian Wang, Peng Li
Doxorubicin (DOX) has been used to treat various types of cancer, but its application is limited due to its heart toxicity as well as other drawbacks. Chronic inhibition of Na+ /H+ exchanger (NHE1) reduces heart failure and reduces the production of reactive oxygen species (ROS); vitamin B6 (VitB6 ) has been demonstrated to have a crucial role in antioxidant mechanism. So, this study was designed to explore the effect of VitB6 supplement on the DOX-induced cardiotoxicity and to imply whether NHE1 is involved...
September 13, 2023: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/37672718/downregulation-of-circular-rna-00091761-protects-against-heart-failure-after-myocardial-infarction-via-microrna-335-3p-ascl4-axis
#19
JOURNAL ARTICLE
Qian Wei, Mengni Jiang, Bin Tang, Lanlan You, Lin Zhao
Our research tended to explore the biological roles and expression status of circ_00091761 in HF after MI. The hypoxia reoxygenation (H/R) injured H9c2 cells model was constructed to simulate HF after MI. The expression of circ_0091761 was examined in H/R injured H9c2 cells by qRT-PCR. Then, the effect of circ_0091761 expression on the proliferation of H/R injured H9c2 cells was evaluated by CCK-8 along with TUNEL assay. Secretion of lactate dehydrogenase (LDH), reactive oxygen species (ROS), Fe2+, glutathione (GSH), and malondialdehyde (MDA) was measured to evaluate cell ferroptosis of H/R injured H9c2 cells, along with protein levels of glutathione peroxidase 4 (GPX4), solute carrier family 7 member 11 (SLC7A11), and transferrin receptor protein (TFRC)...
September 6, 2023: Acta Biochimica Polonica
https://read.qxmd.com/read/37660414/effect-of-sglt2-inhibitor-on-cardiomyopathy-in-a-rat-model-of-t2dm-possible-involvement-of-cardiac-aquaporins
#20
JOURNAL ARTICLE
Somaia A G Eltobshy, Refka Messiha, Emile Metias, Mohamed Sarhan, Randa El-Gamal, Ahmed El-Shaieb, Mohammad Ghalwash
UNLABELLED: Diabetic cardiomyopathy (DCM) causes arrhythmia, heart failure, and sudden death. Empagliflozin, an SGLT-2 (Sodium glucose co-transporter) inhibitor, is an anti-diabetic medication that decreases blood glucose levels by stimulating urinary glucose excretion. Several aquaporins (AQPs) including AQP-1-3 and - 4 and their involvement in the pathogenesis in different cardiac diseases were detected. In the current study the effect of Empagliflozin on diabetic cardiomyopathy and the possible involvement of cardiac AQPs were investigated...
August 21, 2023: Tissue & Cell
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