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Diabetic retinopathy barrier

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https://www.readbyqxmd.com/read/29158262/the-epac-rap1-pathway-prevents-and-reverses-cytokine-induced-retinal-vascular-permeability
#1
Carla J Ramos, Chengmao Lin, Xuwen Liu, David A Antonetti
Increased retinal vascular permeability contributes to macular edema, a leading cause of vision loss in eye pathologies such as diabetic retinopathy, age-related macular degeneration, and central retinal vein occlusions. Pathological changes in vascular permeability are driven by growth factors such as VEGF and by pro-inflammatory cytokines such as TNF-α. Identifying the pro-barrier mechanisms that block vascular permeability and restore the blood-retinal barrier (BRB) may lead to new therapies. The cAMP-dependent guanine nucleotide exchange factor EPAC promotes exchange of GTP in the small GTPase Rap1...
November 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29149824/the-role-of-gene-therapy-in-the-treatment-of-retinal-diseases-a-review
#2
Claudio Campa, Carla Enrica Gallenga, Elena Bolletta, Paolo Perri
Background: Gene therapy represents the therapeutic delivery of nucleic acid polymers into a patient's cells with the aim of treating an underlying disease. Over the past 2 decades this new therapy has made substantial progress owing to better understanding of the pathobiologic basis of various diseases coupled with growth of gene transfer biotechnologies. The eye, in particular, represents a suitable target for such therapy due to the immune privilege provided by the blood-ocular barrier, the ability to directly visualize, access and locally treat the cells and the minimal amount of vector needed given the size of this organ...
November 16, 2017: Current Gene Therapy
https://www.readbyqxmd.com/read/29147964/diabetes-care-in-qatar-a-survey-of-pharmacists-activities-attitudes-and-knowledge
#3
Maguy Saffouh El Hajj, Safae E Abu Yousef, Meena Ali Basri
Background Diabetes mellitus is recognized as a major public health issue and is one of the top ten causes of death in Qatar. Objective To describe the activities, and attitudes of Qatar pharmacists toward diabetes, to measure their diabetes knowledge and to assess their perceived barriers for diabetes care. Setting Community and ambulatory pharmacies in Qatar. Method Study objectives were addressed in a cross sectional survey of community and ambulatory pharmacists in Qatar. A phone call explaining the study was made to all community and ambulatory pharmacists in Qatar...
November 17, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29145552/association-between-perceived-barriers-to-diabetes-self-management-and-diabetic-retinopathy-in-asian-patients-with-type-2-diabetes
#4
Ryan Eyn Kidd Man, Eva K Fenwick, Alfred Tau Liang Gan, Charumathi Sabanayagam, Preeti Gupta, Amudha Aravindhan, Tien Yin Wong, Gavin Siew Wei Tan, Ecosse L Lamoureux
Importance: A patient's perceived barriers to diabetes self-management (DSM) may affect his or her risk of diabetic retinopathy (DR); however, few studies have examined this association. Objective: To examine the association between perceived barriers to DSM and the severity spectrum of DR in Asian patients with type 2 diabetes. Design, Setting, and Participants: A cross-sectional clinic-based study, the Singapore Diabetes Management Project, was conducted from December 28, 2010, to March 20, 2013, at the Singapore National Eye Centre, a tertiary eye care institute...
November 16, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29137959/moving-from-clinic-to-home-what-the-future-holds-for-ophthalmic-telemedicine
#5
Nancy M Holekamp
PURPOSE: To describe the expanding role of telemedicine in healthcare, the key criteria required for a successful device and program implementation, and the current and future role of home monitoring in ophthalmology. DESIGN: Expert perspective METHODS: Analysis with real-world interpretation of home monitoring technologies including current adoption barriers and expanded future demands based on demographic and market forces. RESULTS: Remote patient monitoring represents a paradigm shift in the way physicians care for patients...
November 11, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29119175/protective-effect-of-selenium-supplementation-following-oxidative-stress-mediated-by-glucose-on-retinal-pigment-epithelium
#6
Raquel González de Vega, Montserrat García, María Luisa Fernández-Sánchez, Héctor González-Iglesias, Alfredo Sanz-Medel
There are many conditions that affect the retina. However, diabetic retinopathy (RD) as a complication of Diabetes Mellitus continues to be the leading cause of blindness in working people globally. Diabetic retinopathy is an ocular complication of diabetes that is caused by the deterioration of the blood vessels that supply the retina, which has the consequence that the vision deteriorates irreversibly. The retina, and specifically the retinal pigment epithelium (RPE) is the only neural tissue that is exposed directly and frequently to light, which favors the oxidation of lipids that become extremely toxic to the cells of the retina...
November 9, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29110609/bmp3-is-required-for-integrity-of-blood-brain-barrier-by-promoting-pericyte-coverage-in-zebrafish-embryos
#7
D Lei, X Jin, L Wen, H Dai, Z Ye, G Wang
BACKGROUND: The compromise of blood brain barrier (BBB) integrity is often associated with human hemorrhage stroke and neurodegeneration diseases, including retina diseases, such as age-related macular degeneration and diabetic retinopathy. Brain pericytes play pivotal roles in regulation and maintenance of BBB integrity. However, the mechanisms underlying brain pericyte development to establish BBB integrity remain unclear. METHODS: zebrafish transgenic lines Tg(flk1:GFP; gata1:dsRed), Tg(flk1:GFP), Tg(fli1:GFP) and Tg(BRE:GFP) were used in this work...
November 5, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/29092057/health-system-dynamics-analysis-of-eyecare-services-in-trinidad-and-tobago-and-progress-towards-vision-2020-goals
#8
Tasanee Braithwaite, Blaine Winford, Henry Bailey, Petra Bridgemohan, Debra Bartholomew, Deo Singh, Subash Sharma, Rishi Sharma, Juan Carlos Silva, Alastair Gray, Samuel S Ramsewak, Rupert R A Bourne
Avoidable blindness is an important global public health concern. This study aimed to assess Trinidad and Tobago's progress towards achieving the Pan American Health Organization, 'Strategic Framework for Vision 2020: The Right to Sight-Caribbean Region,' indicators through comprehensive review of the eyecare system, in order to facilitate health system priority setting. We administered structured surveys to six stakeholder groups, including eyecare providers, patients and older adult participants in the National Eye Survey of Trinidad and Tobago...
October 30, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29066926/awareness-of-diabetic-retinopathy-among-patients-with-type-2-diabetes-mellitus-in-jordan
#9
May M Bakkar, Mera F Haddad, Yazan S Gammoh
BACKGROUND: Increasing the level of awareness of diabetic retinopathy among individuals with type 2 diabetes mellitus is considered an important factor for early diagnosis and management of diabetic retinopathy. The aim of this study was to evaluate awareness of diabetic retinopathy among a sample of type 2 diabetes mellitus patients in Jordan. PATIENTS AND METHODS: The study period was from August to December 2015. The sample was selected randomly from patients with type 2 diabetes mellitus from the general population in three main cities of Jordan (Amman, Irbid, and Zarqa)...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29026201/dual-contribution-of-trpv4-antagonism-in-the-regulatory-effect-of-vasoinhibins-on-blood-retinal-barrier-permeability-diabetic-milieu-makes-a-difference
#10
David Arredondo Zamarripa, Ramsés Noguez Imm, Ana María Bautista Cortés, Osvaldo Vázquez Ruíz, Michela Bernardini, Alessandra Fiorio Pla, Dimitra Gkika, Natalia Prevarskaya, Fernando López-Casillas, Wolfgang Liedtke, Carmen Clapp, Stéphanie Thébault
Breakdown of the blood-retinal barrier (BRB), as occurs in diabetic retinopathy and other chronic retinal diseases, results in vasogenic edema and neural tissue damage, causing vision loss. Vasoinhibins are N-terminal fragments of prolactin that prevent BRB breakdown during diabetes. They modulate the expression of some transient receptor potential (TRP) family members, yet their role in regulating the TRP vanilloid subtype 4 (TRPV4) remains unknown. TRPV4 is a calcium-permeable channel involved in barrier permeability, which blockade has been shown to prevent and resolve pulmonary edema...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28993218/novel-therapeutic-targets-in-diabetic-macular-edema-beyond-vegf
#11
Elizabeth A Urias, George A Urias, Finny Monickaraj, Paul McGuire, Arup Das
The leading cause of major vision loss in diabetic persons is diabetic macular edema (DME). The hallmark feature of diabetic retinopathy is the alteration of the blood-retinal barrier (BRB). Inflammation plays a crucial role in DME with involvement of several chemokines and cytokines including vascular endothelial growth factor (VEGF). VEGF is a potent cytokine and vaso-permeability factor that has been targeted in multiple, large clinical trials. Multiple anti-VEGF drugs are widely used in the treatment of diabetic macular edema (DME) as the first line of treatment, and have been shown to be effective in vision improvement and prevention of vision loss...
October 6, 2017: Vision Research
https://www.readbyqxmd.com/read/28978894/dynamic-regulation-of-vascular-permeability-by-vascular-endothelial-cadherin-mediated-endothelial-cell-cell-junctions
#12
Seung-Sik Rho, Koji Ando, Shigetomo Fukuhara
Endothelial cells lining blood vessels regulate vascular barrier function, which controls the passage of plasma proteins and circulating cells across the endothelium. In most normal adult tissues, endothelial cells preserve basal vascular permeability at a low level, while they increase permeability in response to inflammation. Therefore, vascular permeability is tightly controlled by a number of extracellular stimuli and mediators to maintain tissue homeostasis. Accordingly, impaired regulation of endothelial permeability causes various diseases, including chronic inflammation, asthma, edema, sepsis, acute respiratory distress syndrome, anaphylaxis, tumor angiogenesis, and diabetic retinopathy...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28976241/attitudes-and-perceptions-of-eye-care-workers-and-health-administrators-regarding-task-sharing-in-screening-and-detection-for-management-of-diabetic-retinopathy-in-pakistan
#13
Mufarriq Shah, Ayesha Noor, Gail M Ormsby, Rahul Chakrabarti, C Alex Harper, Fakir Amirul Islam, Jill Keeffe
PURPOSE: The shortage of ophthalmologists in many countries is a major barrier to timely provision of eye care. A team work approach to screen, detect and manage diabetic retinopathy (DR) could achieve greater screening coverage of people with diabetes to prevent vision loss. This study aimed to assess the attitudes and perceptions of eye care workers and health administrators regarding task sharing for management of DR. METHODS: Using purposive sampling, 121 eye and health care workers in five selected hospitals in two provinces in Pakistan were recruited...
October 4, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28931831/hyperhomocysteinemia-alters-retinal-endothelial-cells-barrier-function-and-angiogenic-potential-via-activation-of-oxidative-stress
#14
Riyaz Mohamed, Isha Sharma, Ahmed S Ibrahim, Heba Saleh, Nehal M Elsherbiny, Sadanand Fulzele, Khaled Elmasry, Sylvia B Smith, Mohamed Al-Shabrawey, Amany Tawfik
Hyperhomocysteinemia (HHcy) is associated with several human visual disorders, such as diabetic retinopathy (DR) and age-related macular degeneration (AMD). Breakdown of the blood-retinal barrier (BRB) is linked to vision loss in DR and AMD. Our previous work revealed that HHcy altered BRB in retinal endothelial cells in vivo. Here we hypothesize that homocysteine (Hcy) alters retinal endothelial cell barrier function and angiogenic potential via activation of oxidative stress. Human retinal endothelial cells (HRECs) treated with and without different concentrations of Hcy showed a reduction of tight junction protein expression, increased FITC dextran leakage, decreased transcellular electrical resistance and increased angiogenic potential...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923115/serous-retinal-detachment-after-panretinal-photocoagulation-for-proliferative-diabetic-retinopathy-a-case-report
#15
Patrik Schatz, Ahmed Aldayel, Ibrahim Taskintuna, Ehab Abdelkader, Marco Mura
BACKGROUND: Proliferative diabetic retinopathy is a major cause of visual impairment in working-age adults worldwide. Panretinal photocoagulation is a cornerstone in its management; however, it may include a range of side effects and complications, one of these being serous retinal detachment. To the best of our knowledge, this is the first report of the use of intravitreal injection of bevacizumab for serous retinal detachment after panretinal photocoagulation. CASE PRESENTATION: A 24-year-old Saudi man with poorly controlled type 1 diabetes presented with bilateral progressive proliferative retinopathy in spite of several sessions of panretinal photocoagulation...
September 19, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28892947/diabetes-and-diabetic-retinopathy-knowledge-attitude-practice-kap-among-diabetic-patients-in-a-tertiary-eye-care-centre
#16
Nithin Keshav Srinivasan, Deepa John, Grace Rebekah, Evon Selina Kujur, Padma Paul, Sheeja Susan John
INTRODUCTION: Diabetic retinopathy is becoming an increasingly important cause of visual impairment in India. Many diabetic patients who come to our centre have undetected, advanced diabetic retinopathy. If diabetic retinopathy had been detected earlier in these patients, irreversible visual impairment could have been prevented. AIM: To document Knowledge, Attitude and Practice (KAP) patterns of diabetic patients regarding diabetes and diabetic retinopathy, to determine association between them, and to identify barriers to compliance with follow up and treatment regimes...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28882117/awareness-and-practices-regarding-eye-diseases-among-patients-with-diabetes-a-cross-sectional-analysis-of-the-codiab-vd-cohort
#17
Lazaros Konstantinidis, Tania Carron, Eva de Ancos, Léonie Chinet, Isabelle Hagon-Traub, Emilie Zuercher, Isabelle Peytremann-Bridevaux
BACKGROUND: The increasing prevalence of diabetes is leading to a rise of eye diseases, augmenting the risk of sight-threatening complications. The aim of this study was to evaluate prevalence, awareness and practices regarding eye diseases among patients with diabetes in the canton of Vaud, Switzerland. METHODS: A cohort of 323 patients with diabetes completed a self-administered questionnaire assessing prevalence, awareness and practices regarding eye diseases, besides health status and quality of care measures...
September 7, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28856510/diabetic-eye-screening-knowledge-and-perspectives-from-providers-and-patients
#18
REVIEW
Yao Liu, Rebecca Swearingen
PURPOSE OF REVIEW: Diabetic retinopathy remains the leading cause of blindness among working-age US adults even though timely screening and treatment prevent 90% of blindness. We summarize current knowledge and perspectives to better understand why diabetic eye screening rates remain low and future directions towards preventing blindness from diabetes. RECENT FINDINGS: Significant advancements in the past 10 years include primary care and patient-oriented interventions as well as the use of teleophthalmology...
August 31, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28846772/conditional-m%C3%A3-ller-cell-ablation-leads-to-retinal-iron-accumulation
#19
Bailey Baumann, Jacob Sterling, Ying Song, Delu Song, Marcus Fruttiger, Mark Gillies, Weiyong Shen, Joshua L Dunaief
Purpose: Retinal iron accumulation is observed in a wide range of retinal degenerative diseases, including AMD. Previous work suggests that Müller glial cells may be important mediators of retinal iron transport, distribution, and regulation. A transgenic model of Müller cell loss recently demonstrated that primary Müller cell ablation leads to blood-retinal barrier leakage and photoreceptor degeneration, and it recapitulates clinical features observed in macular telangiectasia type 2 (MacTel2), a rare human disease that features Müller cell loss...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28821742/rock-1-mediates-diabetes-induced-retinal-pigment-epithelial-and-endothelial-cell-blebbing-contribution-to-diabetic-retinopathy
#20
Pierre-Raphaël Rothschild, Sawsen Salah, Marianne Berdugo, Emmanuelle Gélizé, Kimberley Delaunay, Marie-Christine Naud, Christophe Klein, Alexandre Moulin, Michèle Savoldelli, Ciara Bergin, Jean-Claude Jeanny, Laurent Jonet, Yvan Arsenijevic, Francine Behar-Cohen, Patricia Crisanti
In diabetic retinopathy, the exact mechanisms leading to retinal capillary closure and to retinal barriers breakdown remain imperfectly understood. Rho-associated kinase (ROCK), an effector of the small GTPase Rho, involved in cytoskeleton dynamic regulation and cell polarity is activated by hyperglycemia. In one year-old Goto Kakizaki (GK) type 2 diabetic rats retina, ROCK-1 activation was assessed by its cellular distribution and by phosphorylation of its substrates, MYPT1 and MLC. In both GK rat and in human type 2 diabetic retinas, ROCK-1 is activated and associated with non-apoptotic membrane blebbing in retinal vessels and in retinal pigment epithelium (RPE) that respectively form the inner and the outer barriers...
August 18, 2017: Scientific Reports
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