keyword
https://read.qxmd.com/read/38512271/limitations-of-assessing-barriers-in-diabetic-retinopathy-screening
#1
JOURNAL ARTICLE
Yu-Mei Yang, Yen-Mou Lu, Chia-Hao Hsu
No abstract text is available yet for this article.
March 21, 2024: JAMA Ophthalmology
https://read.qxmd.com/read/38512268/limitations-of-assessing-barriers-in-diabetic-retinopathy-screening-reply
#2
JOURNAL ARTICLE
Sophia Y Wang, Cassie A Ludwig, Rohith Ravindranath
No abstract text is available yet for this article.
March 21, 2024: JAMA Ophthalmology
https://read.qxmd.com/read/38490291/hyperglycemia-and-circadian-disruption-lead-to-retinal-dysfunction-in-a-stabilized-colony-of-the-fat-sand-rat-psammomys-obesus
#3
JOURNAL ARTICLE
Catherine E Estay-Ahumada, Daniela M Verra, Michel Roux, Fabiana Sassone, Marie-Paule Felder-Schmittbuhl, Christophe Klopp, Dominique Ciocca, Myriam Ly-Le Moal, David Hicks
PURPOSE: The Fat Sand Rat (Psammomys obesus) recapitulates several features of human pre-proliferative diabetic retinopathy, but data are restricted to wild animals, incompatible with stringent biomedical research criteria. To overcome this barrier, we characterized retinal changes in a colony of P. obsesus maintained under strictly controlled housing conditions. METHODS: Animals were maintained on low or high caloric energy diets, and raised under either standard (12 h light/12 h dark) or shortened (5 h light/5 h dark) photoperiods...
March 13, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38489843/smart-nanocarriers-for-the-treatment-of-retinal-diseases
#4
REVIEW
Shuya Liu, Zhike Yan, Zixiang Huang, Huanghao Yang, Jingying Li
Retinal diseases, such as age-related macular degeneration, diabetic retinopathy, and retinoblastoma, stand as the leading causes of irreversible vision impairment and blindness worldwide. Effectively administering drugs for retinal diseases poses a formidable challenge due to the presence of complex ocular barriers and elimination mechanisms. Over time, various approaches have been developed to fabricate drug delivery systems for improving retinal therapy including virus vectors, lipid nanoparticles, and polymers...
March 15, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38475818/transient-but-not-chronic-hyperglycemia-accelerates-ocular-glymphatic-transport
#5
JOURNAL ARTICLE
Christine Delle, Xiaowei Wang, Michael Giannetto, Evan Newbold, Weiguo Peng, Ryszard Stefan Gomolka, Antonio Ladrón-de-Guevara, Neža Cankar, Elise Schiøler Nielsen, Celia Kjaerby, Pia Weikop, Yuki Mori, Maiken Nedergaard
Glymphatic transport is vital for the physiological homeostasis of the retina and optic nerve. Pathological alterations of ocular glymphatic fluid transport and enlarged perivascular spaces have been described in glaucomatous mice. It remains to be established how diabetic retinopathy, which impairs vision in about 50% of diabetes patients, impacts ocular glymphatic fluid transport. Here, we examined ocular glymphatic transport in chronic hyperglycemic diabetic mice as well as in healthy mice experiencing a daily transient increase in blood glucose...
March 12, 2024: Fluids and Barriers of the CNS
https://read.qxmd.com/read/38474297/tgf-%C3%AE-signaling-pathways-in-the-development-of-diabetic-retinopathy
#6
REVIEW
Andrew Callan, Sonal Jha, Laura Valdez, Lois Baldado, Andrew Tsin
Diabetic retinopathy (DR), a prevalent complication of diabetes mellitus affecting a significant portion of the global population, has long been viewed primarily as a microvascular disorder. However, emerging evidence suggests that it should be redefined as a neurovascular disease with multifaceted pathogenesis rooted in oxidative stress and advanced glycation end products. The transforming growth factor-β (TGF-β) signaling family has emerged as a major contributor to DR pathogenesis due to its pivotal role in retinal vascular homeostasis, endothelial cell barrier function, and pericyte differentiation...
March 6, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38381150/improving-access-to-eye-care-through-community-health-screenings-using-artificial-intelligence
#7
JOURNAL ARTICLE
Bhakti Panchal, Samuel Asanad, Rana Malek, Kashif Munir, Lisa S Schocket
PURPOSE: To the best of our knowledge, implementation of artificial intelligence (AI)-based vision screening in community health fair settings has not been previously studied. This prospective cohort study explored the incorporation of AI in a community health fair setting to improve access to eyecare. METHODS: Vision screening was implemented during a community health fair event using an AI-based non-mydriatic fundus camera. In addition, a questionnaire was provided to survey the various barriers to eyecare and assess eye health literacy...
February 21, 2024: Ophthalmic Epidemiology
https://read.qxmd.com/read/38380035/langmuir-monolayer-studies-of-non-ionic-surfactants-and-dotma-for-the-design-of-ophthalmic-niosomes
#8
JOURNAL ARTICLE
Axel Kattar, Emílio V Lage, Matilde Casas, Angel Concheiro, Carmen Alvarez-Lorenzo
The worldwide increase in diabetes entails a rise in associated diseases, with diabetic retinopathy on the forefront of the ocular complications. To overcome the challenges posed by ocular barriers, self-assembled nanocarriers have gathered increasing attention in recent years, with niosomes revealing themselves to be suitable for the delivery of a variety of drugs. This study investigated the mechanical properties of Langmuir monolayers comprising cholesterol, Tween 60, and 1,2-di- O -octadecenyl-3-trimethylammonium propane (DOTMA), both individually and in binary and ternary systems...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38359018/healthcare-resource-utilization-and-costs-in-an-at-risk-population-with-diabetic-retinopathy
#9
JOURNAL ARTICLE
Vivian Rajeswaren, Vivian Lu, Hongan Chen, Jennifer L Patnaik, Niranjan Manoharan
PURPOSE: Several investigators have suggested the cost-effectiveness of earlier screening, management of risk factors, and early treatment for diabetic retinopathy (DR). We aimed to evaluate the extent of health care utilization and cost of delayed care by insurance type in a vulnerable patient population. METHODS: A retrospective analysis of patients with DR was conducted using electronic medical record (EMR) data from January 2014 to December 2020 at Denver Health Medical Center, a safety net institution...
February 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38355716/modeling-early-pathophysiological-phenotypes-of-diabetic-retinopathy-in-a-human-inner-blood-retinal-barrier-on-a-chip
#10
JOURNAL ARTICLE
Thomas L Maurissen, Alena J Spielmann, Gabriella Schellenberg, Marc Bickle, Jose Ricardo Vieira, Si Ying Lai, Georgios Pavlou, Sascha Fauser, Peter D Westenskow, Roger D Kamm, Héloïse Ragelle
Diabetic retinopathy (DR) is a microvascular disorder characterized by inner blood-retinal barrier (iBRB) breakdown and irreversible vision loss. While the symptoms of DR are known, disease mechanisms including basement membrane thickening, pericyte dropout and capillary damage remain poorly understood and interventions to repair diseased iBRB microvascular networks have not been developed. In addition, current approaches using animal models and in vitro systems lack translatability and predictivity to finding new target pathways...
February 14, 2024: Nature Communications
https://read.qxmd.com/read/38339053/molecular-mechanisms-and-therapeutic-implications-of-human-pericyte-like-adipose-derived-mesenchymal-stem-cells-in-an-in-vitro-model-of-diabetic-retinopathy
#11
JOURNAL ARTICLE
Aleksandra Agafonova, Alessia Cosentino, Ivana Roberta Romano, Giovanni Giurdanella, Floriana D'Angeli, Rosario Giuffrida, Debora Lo Furno, Carmelina Daniela Anfuso, Giuliana Mannino, Gabriella Lupo
The blood-retinal barrier (BRB) is strongly compromised in diabetic retinopathy (DR) due to the detachment of pericytes (PCs) from retinal microvessels, resulting in increased permeability and impairment of the BRB. Western blots, immunofluorescence and ELISA were performed on adipose mesenchymal stem cells (ASCs) and pericyte-like (P)-ASCs by co-cultured human retinal endothelial cells (HRECs) under hyperglycemic conditions (HG), as a model of DR. Our results demonstrated that: (a) platelet-derived growth factor receptor (PDGFR) and its activated form were more highly expressed in monocultured P-ASCs than in ASCs, and this expression increased when co-cultured with HRECs under high glucose conditions (HG); (b) the transcription factor Nrf2 was more expressed in the cytoplasmic fraction of ASCs and in the P-ASC nuclear fraction, under normal glucose and, even more, under HG conditions; (c) cytosolic phospholipase A2 activity and prostaglandin E2 release, stimulated by HG, were significantly reduced in P-ASCs co-cultured with HRECs; (d) HO-1 protein content was significantly higher in HG-P-ASCs/HRECs than P-ASCs/HRECs; and (e) VEGF-A levels in media from HG-co-cultures were reduced in P-ASCs/HRECs with respect to ASCs/HRECs...
February 1, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38321393/porous-se-sio-2-nanospheres-alleviate-diabetic-retinopathy-by-inhibiting-excess-lipid-peroxidation-and-inflammation
#12
JOURNAL ARTICLE
Tian Niu, Xin Shi, Xijian Liu, Haiyan Wang, Kun Liu, Yupeng Xu
BACKGROUND: Lipid peroxidation is a characteristic metabolic manifestation of diabetic retinopathy (DR) that causes inflammation, eventually leading to severe retinal vascular abnormalities. Selenium (Se) can directly or indirectly scavenge intracellular free radicals. Due to the narrow distinction between Se's effective and toxic doses, porous Se@SiO2 nanospheres have been developed to control the release of Se. They exert strong antioxidant and anti-inflammatory effects. METHODS: The effect of anti-lipid peroxidation and anti-inflammatory effects of porous Se@SiO2 nanospheres on diabetic mice were assessed by detecting the level of Malondialdehyde (MDA), glutathione peroxidase 4 (GPX4), decreased reduced/oxidized glutathione (GSH/GSSG) ratio, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and interleukin (IL) -1β of the retina...
February 6, 2024: Molecular Medicine
https://read.qxmd.com/read/38313399/imaging-modalities-for-assessing-the-vascular-component-of-diabetic-retinal-disease-review-and-consensus-for-an-updated-staging-system
#13
JOURNAL ARTICLE
Tien-En Tan, Lee M Jampol, Frederick L Ferris, Ramin Tadayoni, Srinivas R Sadda, Victor Chong, Amitha Domalpally, Barbara L Blodi, Elia J Duh, Christine A Curcio, David A Antonetti, Sanjoy Dutta, S Robert Levine, Jennifer K Sun, Thomas W Gardner, Tien Yin Wong
PURPOSE: To review the evidence for imaging modalities in assessing the vascular component of diabetic retinal disease (DRD), to inform updates to the DRD staging system. DESIGN: Standardized narrative review of the literature by an international expert workgroup, as part of the DRD Staging System Update Effort, a project of the Mary Tyler Moore Vision Initiative. Overall, there were 6 workgroups: Vascular Retina, Neural Retina, Systemic Health, Basic and Cellular Mechanisms, Visual Function, and Quality of Life...
2024: Ophthalmol Sci
https://read.qxmd.com/read/38302978/heparanase-inhibition-as-a-systemic-approach-to-protect-the%C3%A2-endothelial-glycocalyx-and-prevent-microvascular-complications-in-diabetes
#14
JOURNAL ARTICLE
Monica Gamez, Hesham E Elhegni, Sarah Fawaz, Kwan Ho Ho, Neill W Campbell, David A Copland, Karen L Onions, Matthew J Butler, Elizabeth J Wasson, Michael Crompton, Raina D Ramnath, Yan Qiu, Yu Yamaguchi, Kenton P Arkill, David O Bates, Jeremy E Turnbull, Olga V Zubkova, Gavin I Welsh, Denize Atan, Simon C Satchell, Rebecca R Foster
BACKGROUND: Diabetes mellitus is a chronic disease which is detrimental to cardiovascular health, often leading to secondary microvascular complications, with huge global health implications. Therapeutic interventions that can be applied to multiple vascular beds are urgently needed. Diabetic retinopathy (DR) and diabetic kidney disease (DKD) are characterised by early microvascular permeability changes which, if left untreated, lead to visual impairment and renal failure, respectively...
February 1, 2024: Cardiovascular Diabetology
https://read.qxmd.com/read/38264181/diabetic-macular-edema-management-a-review-of-anti-vascular-endothelial-growth-factor-vegf-therapies
#15
REVIEW
Abdullah A Cheema, Haider R Cheema
Diabetic macular edema (DME) is a major cause of vision impairment in diabetic individuals, characterized by fluid accumulation in the macula due to a breakdown of the blood-retinal barrier (BRB). This review article explores the role of anti-vascular endothelial growth factor (anti-VEGF) therapies in the management of DME. Anti-VEGF treatments, including ranibizumab, bevacizumab, and aflibercept, have revolutionized DME management by targeting VEGF, a key mediator in DME pathogenesis. We critically examined the efficacy of these therapies in reducing macular edema and improving visual acuity, assessed their safety and tolerability, and explored the variability in treatment response...
January 2024: Curēus
https://read.qxmd.com/read/38250169/do-socioeconomic-inequalities-exist-within-ophthalmology-and-orthoptics-in-the-uk-a-scoping-review
#16
REVIEW
Laura England, Anna O'Connor
INTRODUCTION: It is well documented that socioeconomic disadvantage adversely affects general health and ocular health worldwide. Within orthoptics, while clinicians recognise a relationship between socioeconomic situation and treatment outcome, no previous literature review was found to address this issue. Neither was a UK-specific literature review found to address the same issue for ophthalmology as a whole. AIM: This literature review evaluates evidence for an association between socioeconomic situation and ophthalmic/orthoptic conditions and their treatment outcomes, specifically within the UK...
2024: British and Irish Orthoptic Journal
https://read.qxmd.com/read/38247940/neurovascular-relationships-in-ages-based-models-of-proliferative-diabetic-retinopathy
#17
JOURNAL ARTICLE
Juan S Peña, Ranjini K Ramanujam, Rebecca A Risman, Valerie Tutwiler, Francois Berthiaume, Maribel Vazquez
Diabetic retinopathy affects more than 100 million people worldwide and is projected to increase by 50% within 20 years. Increased blood glucose leads to the formation of advanced glycation end products (AGEs), which cause cellular and molecular dysfunction across neurovascular systems. These molecules initiate the slow breakdown of the retinal vasculature and the inner blood retinal barrier (iBRB), resulting in ischemia and abnormal angiogenesis. This project examined the impact of AGEs in altering the morphology of healthy cells that comprise the iBRB, as well as the effects of AGEs on thrombi formation, in vitro...
January 8, 2024: Bioengineering
https://read.qxmd.com/read/38224327/capabilities-and-limitations-of-student-led-free-vision-screening-programs-in-the-united-states
#18
JOURNAL ARTICLE
Nirupama Devanathan, Melanie Scheive, Baraa S Nawash, Amrish Selvam, Alec Murphy, McKenna Morrow, Shruti Anant, Nickolas Chen, Elizabeth A Martin, Jessica S Kruger, Chi-Wah Rudy Yung, Thomas V Johnson
PURPOSE: The Consortium of Student-Led Eye Clinics (CSLEC), founded in 2021, administered a comprehensive survey to document the types of services, most common diagnoses, and follow-up care protocols offered by student-led free vision screening programs (SLFVSP) in the United States. METHODS: An 81-question institutional review board (IRB)-approved survey was administered to student-led vision screening eye clinics from October 1, 2022 to February 24, 2023. RESULTS: Sixteen SLFVSPs were included in the final analysis, of which 81% (n = 13) conducted variations of fundoscopic examinations and 75% (n = 12) measured intraocular pressure...
January 2, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38223768/implementation-of-a-teleophthalmology-screening-program-for-diabetic-retinopathy-in-new-york-city
#19
JOURNAL ARTICLE
Pamela Capellan, Alexander B Dillon, Geoff Rodriguez, Jason Chua, M Abdallah Mahrous, Kyle Kovacs, Sarah Van Tassel, Donald J D'Amico, Szilard Kiss, Anton Orlin
Purpose: To examine the implementation of a teleophthalmology program for diabetic retinopathy (DR) screening at a metropolitan hospital system and identify the challenges that the clinical teams encountered using the program. Methods: The study was conducted in 2 parts. The first was a pilot retrospective chart review of 300 consecutive patients screened for DR by the teleophthalmology screening program. The baseline variables, DR capture rate and staging, and continuity of care for those diagnosed with DR were analyzed...
2024: Journal of Vitreoretinal Diseases
https://read.qxmd.com/read/38206827/biochemical-changes-to-the-inner-ear-contributing-to-diabetes-induced-hearing-loss-possible-pharmacological-targets-for-therapy
#20
JOURNAL ARTICLE
Ahmed Gedawy, Hani Al-Salami, Crispin R Dass
OBJECTIVES: Biochemical alterations due to diabetes development and progress are complex and diabetes-associated injury to various tissues has been well reported. Nevertheless, a close investigation of the literature demonstrates limited coverage regarding these biochemical and molecular alterations within the inner ear and their impact on the vestibulocochlear environment. A closer look at these may reveal pharmacological targets that could alleviate the severity of disease in patients...
January 11, 2024: Journal of Pharmacy and Pharmacology
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