keyword
MENU ▼
Read by QxMD icon Read
search

hypothalamo

keyword
https://www.readbyqxmd.com/read/28614607/anatomical-and-functional-implications-of-crh-neurons-in-a-septal-nucleus-of-the-avian-brain-an-emphasis-on-glial-neuronal-interaction-via-v1a-receptors-in-vitro
#1
Gurueswar Nagarajan, Alexander Jurkevich, Seong W Kang, Wayne J Kuenzel
Previously, we showed that corticotropin releasing hormone immunoreactive (CRH-ir) neurons in a septal structure are associated with stress and the hypothalamo-pituitary-adrenal axis in birds. In this study, we focused upon CRH-ir neurons located within the septal structure called the nucleus of the hippocampal commissure (NHpC). Immunocytochemical and gene expression analyses were used to identify the anatomical and functional characteristics of cells within the NHpC. A comparative morphometry analysis showed that CRH-ir neurons in the NHpC were significantly larger than CRH-ir parvocellular neurons in the paraventricular nucleus of the hypothalamus (PVN) and lateral bed nucleus of the stria terminalis...
June 14, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28609296/neuroanatomical-pathways-underlying-the-effects-of-hypothalamo-hypophysial-adrenal-hormones-on-exploratory-activity
#2
Robert Lalonde, Catherine Strazielle
When injected via the intracerebroventricular route, corticosterone-releasing hormone (CRH) reduced exploration in the elevated plus-maze, the center region of the open-field, and the large chamber in the defensive withdrawal test. The anxiogenic action of CRH in the elevated plus-maze also occurred when infused in the basolateral amygdala, ventral hippocampus, lateral septum, bed nucleus of the stria terminalis, nucleus accumbens, periaqueductal grey, and medial frontal cortex. The anxiogenic action of CRH in the defensive withdrawal test was reproduced when injected in the locus coeruleus, while the amygdala, hippocampus, lateral septum, nucleus accumbens, and lateral globus pallidus contribute to center zone exploration in the open-field...
June 13, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28587847/molecular-cloning-and-tissue-distribution-of-crh-and-pomc-mrna-in-the-fat-tailed-dunnart-sminthopsis-crassicaudata-an-australian-marsupial
#3
Ellyse B Noy, Melissa K Scott, Sylvia V H Grommen, Kylie A Robert, Bert De Groef
Like all vertebrates, marsupials respond to stressors with the activation of the hypothalamo-pituitary-adrenal axis. However, peptides operating at the higher regulatory levels of this hormonal system, i.e. corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH), have not been investigated in marsupials. Here we report the molecular cloning of the precursor cDNAs of CRH (prepro-CRH) and of ACTH (proopiomelanocortin; POMC) in an Australian marsupial, the fat-tailed dunnart (Sminthopsis crassicaudata)...
June 3, 2017: Gene
https://www.readbyqxmd.com/read/28555252/the-perinatal-effects-of-maternal-caffeine-intake-on-fetal-and-neonatal-brain-levels-of-testosterone-estradiol-and-dihydrotestosterone-in-rats
#4
S Karaismailoglu, M Tuncer, S Bayrak, G Erdogan, E L Ergun, A Erdem
Testosterone, estradiol, and dihydrotestosterone are the main sex steroid hormones responsible for the organization and sexual differentiation of brain structures during early development. The hypothalamo-pituitary-adrenocortical axis, adrenal cells, and gonads play a key role in the production of sex steroids and express adenosine receptors. Caffeine is a non-selective adenosine antagonist; therefore, it can modulate metabolic pathways in these tissues. Besides, the proportion of pregnant women that consume caffeine is ∼60%...
May 29, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28536363/update-on-treatment-guideline-in-fibromyalgia-syndrome-with-focus-on-pharmacology
#5
REVIEW
Sanam Kia, Ernet Choy
Fibromyalgia syndrome (FMS) is a chronic condition with unknown aetiology. The pathophysiology of the disease is incompletely understood; despite advances in our knowledge with regards to abnormal central and peripheral pain processing, and hypothalamo-pituitary-adrenal dysfunction, there is no clear specific pathophysiological therapeutic target. The management of this complex condition has thus perplexed the medical community for many years, and several national and international guidelines have aimed to address this complexity...
May 8, 2017: Biomedicines
https://www.readbyqxmd.com/read/28506881/altered-circadian-patterns-of-salivary-cortisol-in-individuals-with-schizophrenia-a-critical-literature-review
#6
Nathalie Coulon, Sylvie Brailly-Tabard, Michel Walter, Sylvie Tordjman
This article focuses on stress vulnerability in schizophrenia through an integrated clinical and biological approach. The objective of this article is to better understand the relationships between vulnerability, stress and schizophrenia. First, the concept of vulnerability is defined and several models of vulnerability in schizophrenia are reviewed. Second, a section is developed on the biology of stress, and more specifically on the stress responses of the hypothalamo-pitutary adrenal (HPA) axis. Then, studies of cortisol circadian rhythms are summarized, suggesting hyper-reactivity of the HPA axis in patients with schizophrenia and high risk individuals for schizophrenia...
May 12, 2017: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/28506430/george-e-palade-memorial-lecture-my-life-in-pancreatic-research-unexpected-results-may-open-the-door
#7
REVIEW
Makoto Otsuki
The Palade Prize is the most distinguished award of the IAP for achievement in pancreatic research. It is named after George E. Palade, who in 1974 was awarded the Nobel Prize for his work on protein trafficking in pancreatic acinar cells. It is a great honor to be awarded the 2016 Palade Prize. While I was in graduate school, I was conducting research on hypothalamo-pituitary-thyroid axis; after finishing graduate school, I began research on amylase isoenzymes. This was the first step of my pancreatic research...
May 6, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28499018/intracystic-interferon-alpha-in-pediatric-craniopharyngioma-patients-an-international-multicenter-assessment-on-behalf-of-siope-and-ispn
#8
John-Paul Kilday, Massimo Caldarelli, Luca Massimi, Robert Hsin-Hung Chen, Yi Yen Lee, Muh-Lii Liang, Jeanette Parkes, Thuran Naiker, Marie-Lise van Veelen, Erna Michiels, Conor Mallucci, Benedetta Pettorini, Lisethe Meijer, Christian Dorfer, Thomas Czech, Manuel Diezi, Antoinette Yn Schouten-van Meeteren, Stefan Holm, Bengt Gustavsson, Martin Benesch, Hermann L Müller, Anika Hoffmann, Stefan Rutkowski, Joerg Flitsch, Gabriele Escherich, Michael Grotzer, Helen A Spoudeas, Kristian Azquikina, Michael Capra, Rolando Jiménez-Guerra, Patrick MacDonald, Donna L Johnston, Rina Dvir, Shlomi Constantini, Meng-Fai Kuo, Shih-Hung Yang, Ute Bartels
Background: Craniopharyngiomas are frequent hypothalamo-pituitary tumors in children, presenting predominantly as cystic lesions. Morbidity from conventional treatment has focused attention on intracystic drug delivery, hypothesized to cause fewer clinical consequences. However, the efficacy of intracystic therapy remains unclear. We report the retrospective experiences of several global centers using intracystic interferon-alpha. Methods: European Société Internationale d'Oncologie Pédiatrique and International Society for Pediatric Neurosurgery centers were contacted to submit a datasheet capturing pediatric patients with cystic craniopharyngiomas who had received intracystic interferon-alpha...
May 11, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28490690/a-decline-in-female-baboon-hypothalamo-pituitary-adrenal-axis-activity-anticipates-aging
#9
Shanshan Yang, Kenneth G Gerow, Hillary F Huber, McKenna M Considine, Cun Li, Vicki Mattern, Anthony G Comuzzie, Stephen P Ford, Peter W Nathanielsz
Stressors that disrupt homeostasis advance aging. Glucocorticoids regulate multiple processes that determine the aging trajectory. Debate exists regarding life-course circulating glucocorticoid concentrations. Rodent and nonhuman primate studies indicate circulating glucocorticoids fall from early life. We measured fasting morning cortisol in 24 female baboons (6-21 years, human equivalent ~18-70). We also quantified hypothalamic paraventricular nuclear (PVN) arginine vasopressin (AVP), corticotropin-releasing hormone, steroid receptors, and pituitary proopiomelanocortin immunohistochemically in 14 of these females at 6-13 years...
May 9, 2017: Aging
https://www.readbyqxmd.com/read/28475465/food-restriction-alters-salivary-cortisol-and-%C3%AE-amylase-responses-to-a-simulated-weightlifting-competition-without-significant-performance-modification
#10
Alexandre Durguerian, Edith Filaire, Catherine Drogou, Clément Bougard, Mounir Chennaoui
The aim of this investigation was to evaluate the effect of a 6-day food restriction period on the physiological responses and performance of 11 high-level weightlifters. After a period of weight maintenance (T2), they were assigned into two groups depending on whether they lost (Diet group, n = 6) or maintained their body weight (Control group, n = 5) during the course of those 6 days. An evaluation of performance and the measurement of salivary cortisol concentrations and salivary α-amylase (sAA) activity were performed during a simulated weightlifting competition which took place at T2, after a 6-day period of food restriction (T3)...
May 5, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28450069/circulating-steroids-negatively-correlate-with-tinnitus
#11
Pavel Chrbolka, Zoltán Palúch, Martin Hill, Štefan Alušík
While not a disease entity in itself; symptoms of tinnitus (from Latin tinnio - clink) accompany a number of diseases. Tinnitus prevalence increases with age, deteriorates one's quality of life, and may even result in suicidal behavior. Tinnitus develops in response to a variety of risk factors, otoxic substances, noise exposure, hearing disorders, and psychological alterations. Tinnitus is closely related to mood, depression, and psychological state. In the present study, we focused on alterations of the steroid metabolome and particularly neuroactive, neuroprotective, and immunomodulatory steroids in patients with tinnitus...
April 25, 2017: Steroids
https://www.readbyqxmd.com/read/28441891/investigational-and-experimental-gnrh-analogs-and-associated-neurotransmitters
#12
Zeev Blumenfeld
The GnRH agonistic analogs enable for desensitizing the hypothalamo-pituitary-gonadal axis in malignant and benign conditions where minimizing the production of sex hormones, or blocking ovulation is necessary. The possible indications are prostate cancer, benign prostate hyperplasia, breast cancer, endometriosis, precocious puberty, uterine leiomyomata, assisted reproduction (ART)/in vitro fertilization (IVF), PCOS, minimizing the gonadotoxic effect of chemotherapy in young women, and possibly ovarian cancer...
May 4, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28418336/intracranial-lesions-in-children-and-adolescents-with-morbid-obesity
#13
Ayça Törel Ergür, Sevinç Odabaşı Güneş, Sinan Tan, Ü Ayşe Tandırcıoğlu
BACKGROUND: Intracranial lesions may affect the hypothalamo-hypophyseal axis and lead to some neuro-endocrinological dysfunctions (hyperphagia, sleep disorders and hormonal dysfunctions). There is a very limited number of studies about childhood obesity and intracranial lesions. AIMS: To evaluate the incidence of intracranial lesions and its role in clinical symptoms and aetiology in cases with morbid obesity who have been admitted to the paediatric endocrinology department with this complaint...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28412090/pituitary-gland-in-bipolar-disorder-and-major-depression-evidence-from-structural-mri-studies-special-section-on-translational-and-neuroscience-studies-in-affective-disorders-section-editor-maria-nobile-md-phd-this-section-of-jad-focuses-on-the-relevance-of
#14
G Delvecchio, A C Altamura, J C Soares, P Brambilla
BACKGROUND: The function of the hypothalamo-pituitary-adrenal axis (HPA) has been widely investigated in mood disorders based on its role in regulating stress response. Particularly, Magnetic Resonance Imaging (MRI) reports have explored pituitary gland (PG) in both bipolar disorder (BD) and major depressive disorder (MDD). In this context, the present review summarizes the results from MRI studies with the final aim of commenting on the presence of common or distinct PG structural alterations between these two disabling illnesses...
April 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28377717/biomarkers-associated-with-cognitive-impairment-in-treated-cancer-patients-potential-predisposition-and-risk-factors
#15
REVIEW
Hélène Castel, Angeline Denouel, Marie Lange, Marie-Christine Tonon, Martine Dubois, Florence Joly
Purpose: Cognitive impairment in cancer patients induced, at least in part, by treatment are frequently observed and likely have negative impacts on patient quality of life. Such cognitive dysfunctions can affect attention, executive functions, and memory and processing speed, can persist after treatment, and their exact causes remain unclear. The aim of this review was to create an inventory and analysis of clinical studies evaluating biological markers and risk factors for cognitive decline in cancer patients before, during, or after therapy...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28348023/a-homozygous-mutation-of-gnrhr-in-a-familial-case-diagnosed-with-polycystic-ovary-syndrome
#16
Sandrine Caburet, Ronit Beck Fruchter, Bérangère Legois, Marc Fellous, Stavit Shalev, Reiner A Veitia
CONTEXT: PCOS is a heterogeneous condition characterized by hyperandrogenism and chronic anovulation and affects about 10% of women. Its etiology is poorly known, but a dysregulation of gonadotropin secretion is one of its hallmarks. OBJECTIVE: As the etiology of PCOS is unclear, we have performed a genome-wide analysis of a consanguineous family with three sisters diagnosed with PCOS. METHODS: Whole-exome sequencing and Sanger sequencing confirmation...
May 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28339602/gonadotropin-releasing-hormone-kisspeptin-and-gonadal-steroids-directly-modulate-nucleobindin-2-nesfatin-1-in-murine-hypothalamic-gonadotropin-releasing-hormone-neurons-and-gonadotropes%C3%A2
#17
A Hatef, S Unniappan
Neuroendocrine regulation of metabolism and reproduction are tightly interlinked. Nesfatin-1 is an 82 amino acid metabolic peptide derived from nucleobindin-2 (NUCB2). NUCB2 mRNA and protein significantly increase in the hypothalamus of rats during puberty-to-adult transition. Administration of nesfatin-1 modulates circulating LH and testosterone in male rats. However, whether nesfatin-1 acts directly on neurons and gonadotropes remain unknown. In addition, whether reproductive hormones of the hypothalamo-pituitary gonadal axis modulate NUCB2/nesfatin-1 is unclear...
March 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28339047/hypothalamo%C3%A2-hypophysial-system-in-rats-with-autotransplantation-of-the-adrenal-cortex
#18
Nae Takizawa, Susumu Tanaka, Souichi Oe, Taro Koike, Tadashi Matsuda, Hisao Yamada
Patients with bilateral pheochromocytoma often require an adrenalectomy. Autotransplantation of the adrenal cortex is an alternative therapy that could potentially be performed instead of receiving glucocorticoid replacement following adrenalectomy. Adrenal cortex autotransplantation aims to avoid the side effects of long‑term steroid treatment and adrenal insufficiency. Although the function of the hypothalamo‑hypophysial system is critical for patients who have undergone adrenal cortex autotransplantation, the details of that system, with the exception of adrenocorticotropic hormone in the subjects with adrenal autotransplantation, have been overlooked for a long time...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28330882/adiponectin-and-resistin-potential-metabolic-signals-affecting-hypothalamo-pituitary-gonadal-axis-in-females-and-males-of-different-species
#19
REVIEW
Agnieszka Rak, Namya Mellouk, Pascal Froment, Joëlle Dupont
Adipokines, including adiponectin and resistin, are cytokines produced mainly by the adipose tissue. They play a significant role in metabolic functions that regulate the insulin sensitivity and inflammation. Alterations in adiponectin and resistin plasma levels, or their expression in metabolic and gonadal tissues, are observed in some metabolic pathologies, such as obesity. Several studies have shown that these two hormones and the receptors for adiponectin, AdipoR1 and AdipoR2 are present in various reproductive tissues in both sexes of different species...
June 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28324042/interleukin-1-antagonism-decreases-cortisol-levels-in-obese-individuals
#20
Sandrine Andrea Urwyler, Philipp Schuetz, Fahim Ebrahimi, Marc Y Donath, Mirjam Christ-Crain
Context: Increased cortisol levels in obesity may contribute to the associated metabolic syndrome. In obesity, the activated innate immune system leads to increased interleukin (IL)-1β, which is known to stimulate the release of adrenocorticotropin hormone (ACTH). Objectives: We hypothesized that in obesity IL-1 antagonism would result in downregulation of the hypothalamo-pituitary-adrenal axis, leading to decreased cortisol levels. Design and Participants: In this prospective intervention study, we included 73 patients with obesity (body mass index [BMI] ≥30 kg/m2) and at least one additional feature of the metabolic syndrome...
May 1, 2017: Journal of Clinical Endocrinology and Metabolism
keyword
keyword
81572
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"