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https://www.readbyqxmd.com/read/29117898/the-contribution-of-immune-infiltrates-and-the-local-microenvironment-in-the-pathogenesis-of-osteosarcoma
#1
Marie-Françoise Heymann, Frédéric Lézot, Dominique Heymann
Osteosarcoma is a rare primary bone cancer characterized by cancer cells producing calcified osteoid extracellular matrix and inducing lung metastases with a high frequency. The local microenvironment defined several tumor niches controlling the tumor growth and cell extravasation. The immune infiltrate composes one of these niches. The immune environment of osteosarcoma is mainly composed by T-lymphocytes and macrophages but also contains other subpopulations including B-lymphocytes and mast cells. Osteosarcoma cells control the recruitment and differentiation of immune infiltrating cells and establish a local immune tolerant environment favorable to the tumor growth, drug resistance and the occurrence of metastases...
November 2, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29071027/antibacterial-effect-of-diode-laser-in-pulpectomy-of-primary-teeth
#2
Zahra Bahrololoomi, Reza Fekrazad, Shiva Zamaninejad
Introduction: Laser irradiation has been suggested as an adjunct to traditional methods of canal preparation but few studies are available on the antibacterial effect of diode laser in pulpectomy of primary teeth. The purpose of the present study is to investigate the antibacterial effect of diode laser in pulpectomy of primary teeth, in addition to define the optimal and harmless diode lasing conditions in the root canal. Methods: A total of 125 single rooted primary teeth were selected. After traditional canal cleaning, they were divided in 2 groups...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29070950/periodontal-ligament-injection-versus-routine-local-infiltration-for-nonsurgical-single-posterior-maxillary-permanent-tooth-extraction-comparative-double-blinded-randomized-clinical-study
#3
Mohammad H Al-Shayyab
AIM: The aim of this study was to evaluate the efficacy of, and patients' subjective responses to, periodontal ligament (PDL) anesthetic injection compared to traditional local-anesthetic infiltration injection for the nonsurgical extraction of one posterior maxillary permanent tooth. MATERIALS AND METHODS: All patients scheduled for nonsurgical symmetrical maxillary posterior permanent tooth extraction in the Department of Oral and Maxillofacial Surgery at the University of Jordan Hospital, Amman, Jordan over a 7-month period were invited to participate in this prospective randomized double-blinded split-mouth study...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29070883/combined-immunotherapy-with-anti-pdl-1-pd-1-and-anti-cd4-antibodies-cures-syngeneic-disseminated-neuroblastoma
#4
Valentina Rigo, Laura Emionite, Antonio Daga, Simonetta Astigiano, Maria Valeria Corrias, Concetta Quintarelli, Franco Locatelli, Silvano Ferrini, Michela Croce
Anti-PD-1 or anti-PD-L1 blocking monoclonal antibodies (mAbs) have shown potent anti-tumor effects in adult cancer patients and clinical studies have recently been started in pediatric cancers, including high-risk/relapsing neuroblastoma (NB). Therefore, we studied the effects of anti-PD-1/PD-L1 mAbs in two syngeneic models of disseminated NB generated by the injection of either Neuro2a or NXS2 cells, which express PD-L1. In addition, we tested the combination of these agents with the immune-enhancing cytokine IL-21, the Ecto-NTPDase inhibitor POM-1, an anti-CD25 mAb targeting Treg cells, or an anti-CD4 mAb...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29068580/orthodontic-intrusion-of-periodontally-compromised-maxillary-incisors-3-dimensional-finite-element-method-analysis
#5
Liwia E Minch, Michał Sarul, Rafał Nowak, Beata Kawala, Joanna Antoszewska-Smith
BACKGROUND: Loading of the compromised periodontium with orthodontic forces produces different results than those achieved in patients with healthy periodontal support. Determining the force value at a level preventing further deterioration of the patient's periodontal status, thus delivering the most precisely individualized "dose" of loading, seems to be crucial for the successful intrusion of teeth with reduced periodontal support. OBJECTIVES: The aim of the study was to determine the range of force values efficiently intruding maxillary incisors without further compromising the initially-impaired periodontal status...
August 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29063603/effects-of-paraoxonase-1-on-the-cytodifferentiation-and-mineralization-of-periodontal-ligament-cells
#6
R Masumoto, J Kitagaki, M Matsumoto, S Miyauchi, C Fujihara, M Yamashita, S Yamada, M Kitamura, S Murakami
BACKGROUND AND OBJECTIVE: Single nucleotide polymorphisms (SNPs) of paraoxonase 1 (PON1) are known to be associated with the pathogenesis of osteoporosis and periodontitis. However, the effects of PON1 on the osteoblastic differentiation of periodontal ligament (PDL) cells are unclear. In this study, we examined the effects of PON1 on the osteoblastic differentiation of PDL cells, and analysed the role of PON1 SNPs on the pathogenesis of aggressive periodontitis (AgP) in the Japanese population...
October 24, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29055015/small-molecule%C3%A2-inhibition-of-pd-1-transcription-is-an-effective-alternative-to-antibody-blockade-in-cancer-therapy
#7
Alison Taylor, David Rothstein, Christopher E Rudd
The impact of PD-1 immune checkpoint therapy prompts exploration of other strategies to downregulate PD-1 for cancer therapy. We previously showed that the serine/threonine kinase, glycogen synthase kinase GSK-3α/β, is a central regulator of PD-1 transcription in CD8+ T cells. Here, we show that the use of small molecule inhibitors of GSK-3α/β (GSK-3i) to reduce pcdc1 (PD-1) transcription and expression was as effective as anti-PD-1 and PDL-1 blocking antibodies in the control of B16 melanoma, or EL4 lymphoma, in primary tumor and metastatic settings...
October 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/29016746/effects-of-low-magnitude-high-frequency-mechanical-vibration-combined-with-compressive-force-on-human-periodontal-ligament-cells-in-vitro
#8
Sutiwa Benjakul, Suwanna Jitpukdeebodintra, Chidchanok Leethanakul
Objective: Vibration can be used to accelerate tooth movement, though the exact mechanisms remain unclear. This study aimed to investigate the effects of low magnitude high frequency (LMHF) vibration combined with compressive force on periodontal ligament (PDL) cells in vitro. Materials and methods: Human PDL cells were isolated from extracted premolar teeth of four individuals. To determine the optimal frequency for later used in combination with compressive force, three cycles of low-magnitude (0...
September 7, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28994643/shorter-treatment-intervals-of-east-asians-with-port-wine-stain-with-pulsed-dye-laser-are-safe-and-effective-a-prospective-side-by-side-comparison
#9
Wenxin Yu, Jiafang Zhu, Shih-Jen Changc, Hui Chen, Yunbo Jin, Xi Yang, Tianyou Wang, Lei Chang, Yijie Chen, Gang Ma, Xiaoxi Lin
OBJECTIVE: To compare the safety and efficacy of pulsed dye laser (PDL) at different intervals for the treatment of East Asians with Port-Wine Stain (PWS). BACKGROUND: The population of East Asians around the world is about 1.6 billion, and they are considered to have more melanin in their skin compared with Caucasians. Nevertheless, no studies about the optimal treatment intervals for East Asians with PWS have been carried out. METHODS: We prospectively investigated 39 East Asian patients with untreated PWS...
October 10, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28971402/-mir-140-3p-downregulation-in-association-with-pdl-1-overexpression-in-many-cancers-a-review-from-the-literature-using-predictive-bioinformatics-tools
#10
Nikolaos Kapodistrias, Catherine Bobori, Georgia Theocharopoulou
Programmed death-ligand 1 (PD-L1) has been speculated to play a critical role in suppression of the immune system and it can be upregulated in cancer cells, which may allow cancers to evade the host immune system. MicroRNAs (miRNAs) are small non-coding RNA molecules (containing about 22 nucleotides), that function in RNA silencing and post-transcriptional regulation of gene expression. MiRNAs were found deregulated (upregulated or downregulated) and implicated in cancer development with various roles which depend on their gene target...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28932633/cd163-positive-tumor-associated-macrophages-and-cd8-positive-cytotoxic-lymphocytes-are-powerful-diagnostic-markers-for-the-therapeutic-stratification-of-osteosarcoma-patients-an-immunohistochemical-analysis-of-the-biopsies-fromthe-french-os2006-phase-3-trial
#11
Anne Gomez-Brouchet, Claire Illac, Julia Gilhodes, Corinne Bouvier, Sébastien Aubert, Jean-Marc Guinebretiere, Béatrice Marie, Frédérique Larousserie, Natacha Entz-Werlé, Gonzague de Pinieux, Thomas Filleron, Véronique Minard, Vincent Minville, Eric Mascard, François Gouin, Marta Jimenez, Marie-Cécile Ledeley, Sophie Piperno-Neumann, Laurence Brugieres, Françoise Rédini
The French phase 3 trial (OS 2006) testing zoledronic acid, an osteoclast inhibitor, with chemotherapy and surgery did not improve the outcome of patients with osteosarcoma (OS). To understand this unexpected result, the presence of infiltrating immune cells was investigated in 124 pre-therapeutic biopsies of patients enrolled in the trial. The percentage of CD68/CD163 tumor-infiltrating macrophages (TAMs), CD8(+) lymphocytes, osteoclasts, and the PD1/PDL-1 checkpoint were assessed by immunohistochemistry. M1/M2 macrophage polarization was characterized by pSTAT1/CMAF staining...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28881302/nanoparticulation-of-bovine-serum-albumin-and-poly-d-lysine-through-complex-coacervation-and-encapsulation-of-curcumin
#12
L Maldonado, R Sadeghi, J Kokini
Soluble coacervate nanoparticles were fabricated by mixing bovine serum albumin (BSA) and poly-d-lysine with low (LMW-PDL) and high molecular weights (HMW-PDL). The particle size was influenced by molecular weight, mass ratio of polyelectrolytes (PEs), and salt concentration. The smallest nanoparticles had a diameter of 212±11nm which was achieved with LMW-PDL dissolved with 0.1M NaCl at pH 7 and a mass ratio of 2.0 (BSA: PDL). SEM images showed that coacervate nanoparticles of LMW-PDL are relatively spherical in shape, while nanoparticles of HMW-PDL were irregular...
August 30, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28878676/pd-1-and-pd-l1-checkpoint-signaling-inhibition-for-cancer-immunotherapy-mechanism-combinations-and-clinical-outcome
#13
REVIEW
Hashem O Alsaab, Samaresh Sau, Rami Alzhrani, Katyayani Tatiparti, Ketki Bhise, Sushil K Kashaw, Arun K Iyer
Several cancers are highly refractory to conventional chemotherapy. The survival of tumors in several cases is assisted by checkpoint immunomodulation to maintain the imbalance between immune surveillance and cancer cell proliferation. Check point antibody inhibitors, such as anti-PD-1/PD-L1, are a novel class of inhibitors that function as a tumor suppressing factor via modulation of immune cell-tumor cell interaction. These checkpoint blockers are rapidly becoming a highly promising cancer therapeutic approach that yields remarkable antitumor responses with limited side effects...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28869918/circulating-cd4-pd-1-and-cd8-pd-1-t-cells-are-profoundly-decreased-at-the-onset-of-fulminant-type-1-diabetes-and-are-restored-by-treatment-contrasting-with-cd4-cd25-foxp3-regulatory-t-cells
#14
Toshie Iijima, Kanako Kato, Teruo Jojima, Takanori Tomotsune, Maiko Fukushima, Kunihiro Suzuki, Yoshimasa Aso
Programed cell death protein-1 (PD-1) is an inhibitory receptor expressed by T cells that downregulates the activation and proliferation of these cells to maintain peripheral self-tolerance. Recent studies reported some cases of new-onset type 1 diabetes (T1D) under anti-PD1 or PDL-1 antibodies. We demonstrated that circulating both CD4+PD-1+ and CD8+PD-1+ T cells were profoundly reduced at the onset of fulminant T1D and were restored by treatment in two patients with fulminant T1D.
July 31, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28861710/healing-of-root-and-surrounding-periodontium-after-root-damage-with-miniscrew-implants-a-histomorphologic-study-in-dogs
#15
Yingtao Lv, Zhaoqiang Zhang, Yuan Su, Peiyan Yuan, Weiqun Ma, Wenhua Huang, Pingping Xu
OBJECTIVES: The main purpose of this study was to investigate the detailed healing process of the roots and surrounding periodontium [cementum, periodontal ligament (PDL), and bone] at different time points after intentional root damage with miniscrew implants (MSIs). MATERIALS AND METHODS: After cone-beam computed tomography examination and measurement, a total of 78 premolar and molar roots from five beagle dogs were intentionally damaged by implanting miniscrews in the interradicular region...
August 31, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28858925/pulsed-dye-laser-at-subpurpuric-settings-for-the-treatment-of-pulsed-dye-laser-induced-ecchymoses-in-patients-with-port-wine-stains
#16
Jeremy A Brauer, Joshua A Farhadian, Leonard J Bernstein, Yoon-Soo Bae, Roy G Geronemus
BACKGROUND: Post-procedure purpura is a major complaint of patients with port-wine stains (PWSs) treated with pulsed dye laser (PDL). OBJECTIVE: To assess the safety and efficacy of using PDL at nonpurpuric settings to treat ecchymoses that develop within PWSs after treatment with PDL. MATERIALS AND METHODS: Prospective, randomized, controlled study using 595-nm PDL for treatment of PWSs and laser-induced ecchymoses. Port-wine stains were treated in entirety at baseline...
August 30, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28855904/immunological-properties-of-murine-parthenogenetic-stem-cell-derived-cardiomyocytes-and-engineered-heart-muscle
#17
Michael Didié, Satish Galla, Vijayakumar Muppala, Ralf Dressel, Wolfram-Hubertus Zimmermann
Pluripotent parthenogenetic stem cells (pSCs) can be derived by pharmacological activation of unfertilized oocytes. Homozygosity of the major histocompatibility complex (MHC) in pSCs makes them an attractive cell source for applications in allogeneic tissue repair. This was recently demonstrated for pSC-based tissue-engineered heart repair. A detailed analysis of immunological properties of pSC-derived cardiomyocytes and engineered heart muscle (EHM) thereof is, however, lacking. The aim of this study was to determine baseline and cytokine-inducible MHC class I and MHC class II as well as programmed death ligand-1 (PDL-1) and co-stimulatory protein (CD40, CD80, CD86) expression in pSC-derived cardiomyocytes and pSC-EHM in vitro and in vivo...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28835018/effect-of-fgf-2-tgf-%C3%AE-1-and-bmps-on-teno-ligamentogenesis-and-osteo-cementogenesis-of-human-periodontal-ligament-stem-cells
#18
Sun-Yi Hyun, Ji-Hye Lee, Kyung-Jung Kang, Young-Joo Jang
The periodontal ligament (PDL) is the connective tissue between tooth root and alveolar bone containing mesenchymal stem cells (MSC). It has been suggested that human periodontal ligament stem cells (hPDLSCs) differentiate into osteo/cementoblast and ligament progenitor cells. The periodontitis is a representative oral disease where the PDL tissue is collapsed, and regeneration of this tissue is important in periodontitis therapy. Fibroblast growth factor-2 (FGF-2) stimulates proliferation and differentiation of fibroblastic MSCs into various cell lineages...
August 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28834247/regeneration-of-the-cementum-and-periodontal-ligament-using-local-bdnf-delivery-in-class-ii-furcation-defects
#19
Ryo Jimbo, Jessica Singer, Nick Tovar, Charles Marin, Rodrigo Neiva, Estevam A Bonfante, Malvin N Janal, Hugues Contamin, Paulo G Coelho
Periodontal furcation defects are usually addressed by the placement of a physical barrier which may limit the regenerative potential of periodontal wounds. This study morphometrically quantified the regenerative effect of brain-derived neurotrophic factor (BDNF) in furcation defects in a non-human primate model. Grade II furcation defects (with and without induced inflammation prior to surgery) were created on the first and second molars of eight non-human primates. Defects were treated with open flap debridement and subsequently filled with either: Group A; BDNF (500 µg mL(-1) ) in high-molecular weight-hyaluronic acid (HMW-HA), Group B; BDNF (50 µg mL(-1) ) in HMW-HA, Group C; HMW-HA acid only, Group D; unfilled defect, or Group E; BDNF (500 µg mL(-1) ) in saline...
August 21, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28831825/pdl-1-pd1-inhibitors-antibody-or-antinobody
#20
Fouad Aoun, Elie El Rassy, Tarek Assi, Joseph Kattan
No abstract text is available yet for this article.
August 2017: Future Oncology
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