keyword
MENU ▼
Read by QxMD icon Read
search

PDL 1

keyword
https://www.readbyqxmd.com/read/27911476/nd-yag-and-pulsed-dye-laser-therapy-in-infantile-hemangiomas-a-retrospective-analysis-of-271-treated-hemangiomas-in-149-children
#1
F Hartmann, A Lockmann, L-L Grönemeyer, H A Haenssle, M Zutt, H von Fintel, I Kühnle, M P Schön, K-M Thoms
BACKGROUND: Infantile hemangiomas (IH) are common benign tumors in infancy. Most IH resolve spontaneously, but some require treatment due to ulceration, functional impairment or cosmetic disfiguration. While systemic propranolol is effective in many cases, laser therapy may be a safe topical alternative. OBJECTIVE: To assess the efficacy of combined Nd:YAG/pulsed dye laser (PDL) or PDL alone for therapy of IH. PATIENTS AND METHODS: 271 IH in 149 infants were treated with combined Nd:YAG/PDL or PDL alone...
December 2, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27911144/comparison-of-pulsed-dye-laser-versus-combined-pulsed-dye-laser-and-nd-yag-laser-in-the-treatment-of-inflammatory-acne-vulgaris
#2
Manal Mohamed Salah El Din, Nevien Ahmed Samy, Amira Eid Salem
BACKGROUND: Both pulsed dye laser and combined 585/1,064-nm (sequential dual-wave-length PDL and Nd:YAG) laser improves inflammatory skin disorders including acne vulgaris. OBJECTIVE: To compare the efficacy of 585 nm pulsed dye laser versus sequential dual-wave-length PDL and Nd:YAG in treatment of acne vulgaris. PATIENTS AND METHOD: Thirty patients complaining of acne vulgaris were treated with a single pass of PDL alone on half of the face and a single pass of combined 585/1064-nm laser on the other half for four treatment sessions at 2 weeks interval, then assessed by the count and severity of the acne lesions & digital camera photographs Results: The study showed that inflammatory acne lesions count was significantly reduced by 82...
December 2, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27907187/substance-p-induces-ho-1-expression-in-raw-264-7-cells-promoting-switch-towards-m2-like-macrophages
#3
Giovanna Montana, Nadia Lampiasi
Substance P (SP) is a neuropeptide that mediates many physiological as well as inflammatory responses. Recently, SP has been implicated in the resolution of inflammation through induction of M2 macrophages phenotype. The shift between M1-like and M2-like, allowing the resolution of inflammatory processes, also takes place by means of hemeoxygenase-1 (HO-1). HO-1 is induced in response to oxidative stress and inflammatory stimuli and modulates the immune response through macrophages polarisation. SP induces HO-1 expression in human periodontal ligament (PDL), the latter potentially plays a role in cytoprotection...
2016: PloS One
https://www.readbyqxmd.com/read/27905816/cementocyte-cell-death-occurs-in-rat-cellular-cementum-during-orthodontic-tooth-movement
#4
Humihiro Matsuzawa, Naoko Toriya, Yuya Nakao, Moe Konno-Nagasaka, Toshiya Arakawa, Miki Okayama, Itaru Mizoguchi
OBJECTIVE: To clarify the mechanism of root resorption during orthodontic treatment, we examined cementocyte cell death and root resorption in the cellular cementum on the pressure side during experimental tooth movement. MATERIALS AND METHODS: Using 8-week-old male Wistar rats, the right first molar was pushed mesiobuccally with a force of 40 g by a Ni-Ti alloy wire while the contralateral first molar was used as a control. Localization and number of cleaved caspase-3-positive and single-stranded DNA (ssDNA) - positive cells were evaluated using dual-label immunohistochemistry with anticleaved caspase-3 and anti-ssDNA antibodies...
December 1, 2016: Angle Orthodontist
https://www.readbyqxmd.com/read/27901202/in-vivo-performance-of-different-scaffolds-for-dental-pulp-stem-cells-induced-for-odontogenic-differentiation
#5
Cigdem Atalayin, Huseyin Tezel, Taner Dagci, Nefise Ulku Karabay Yavasoglu, Gulperi Oktem, Timur Kose
This study was designed to determine the in vivo performance of three different materials as scaffolds for dental pulp stem cells (DPSC) undergoing induced odontogenic differentiation. An odontogenic medium modified by the addition of recombinant human bone morphogenetic protein 2 was used in the experimental groups to induce differentiation. Mesenchymal stem cell medium was used in the control groups. DPSC were transplanted onto the backs of mice via three scaffolds: copolymer of L-lactide and DL-lactide (PLDL), copolymer of DL-lactide (PDL) and hydroxyapatite tricalcium phosphate (HA/TCP)...
November 28, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27832279/artificial-polymeric-scaffolds-as-extracellular-matrix-substitutes-for-autologous-conjunctival-goblet-cell-expansion
#6
Min He, Thomas Storr-Paulsen, Annie L Wang, Chiara E Ghezzi, Siran Wang, Matthew Fullana, Dimitrios Karamichos, Tor P Utheim, Rakibul Islam, May Griffith, M Mirazul Islam, Robin R Hodges, Gary E Wnek, David L Kaplan, Darlene A Dartt
Purpose: We fabricated and investigated polymeric scaffolds that can substitute for the conjunctival extracellular matrix to provide a substrate for autologous expansion of human conjunctival goblet cells in culture. Methods: We fabricated two hydrogels and two silk films: (1) recombinant human collagen (RHC) hydrogel, (2) recombinant human collagen 2-methacryloylxyethyl phosphorylcholine (RHC-MPC) hydrogel, (3) arginine-glycine-aspartic acid (RGD) modified silk, and (4) poly-D-lysine (PDL) coated silk, and four electrospun scaffolds: (1) collagen, (2) poly(acrylic acid) (PAA), (3) poly(caprolactone) (PCL), and (4) poly(vinyl alcohol) (PVA)...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27828142/design-and-fabrication-of-a-low-loss-and-asymmetric-1%C3%A2-%C3%A3-%C3%A2-5-arbitrary-optical-power-splitter
#7
Liang Liang Wang, Jun Ming An, Jia Shun Zhang, Yuan Da Wu, Jian Guang Li, Xiao Jie Yin, Hong Jie Wang, Yue Wang, Fei Zhong, Qiang Zha, Xiong Wei Hu
In this paper, a low-loss and wavelength-insensitive asymmetric 1×5 arbitrary optical power splitter is designed and optimized, which is composed of a three-branch and two Y-branch elements. A low-loss and wavelength-independent arbitrary 1×5 optical power splitter can be obtained. Asymmetric 1×5 optical power splitters of different output ratios are fabricated using silica-based planar lightwave circuit (PLC) technology on a 6-inch quartz substrate. The measured results show that the IL<sub>output1</sub>, IL<sub>output2∼5</sub>, UNIF<sub>output2∼5</sub>, PDL, and WDL of the output ratio 33%:67%, 50%:50%, and 95%:5% are less than (5...
October 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/27816392/assessing-pdl-1-and-pd-1-in-non-small-cell-lung-cancer-a-novel-immunoscore-approach
#8
Erna-Elise Paulsen, Thomas K Kilvaer, Mehrdad Rakaee Khanehkenari, Samer Al-Saad, Sigurd M Hald, Sigve Andersen, Elin Richardsen, Nora Ness, Lill-Tove Busund, Roy M Bremnes, Tom Donnem
INTRODUCTION: Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) or its ligand, PD-L1, have gained momentum in the treatment of non-small cell lung cancer (NSCLC). However, their prognostic significance remains controversial. The present study evaluated the expression of PD-L1 and PD-1 and their potential role in an Immunoscore, supplementing the TNM classification of NSCLC. MATERIALS AND METHODS: Tissue microarrays constructed from tumor tissue samples from 2 cohorts of a total of 536 patients (University Hospital of North Norway, n = 285; Nordland Hospital, n = 251) with primary resected stage I to IIIA NSCLC...
October 5, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27806346/cross-talk-between-microbiota-and-immune-fitness-to-steer-and-control-response-to-anti-pd-1-pdl-1-treatment
#9
REVIEW
Andrea Botticelli, Ilaria Zizzari, Federica Mazzuca, Paolo Antonio Ascierto, Lorenza Putignani, Luca Marchetti, Chiara Napoletano, Marianna Nuti, Paolo Marchetti
Immune Checkpoint Inhibitors (ICIs) are improving the survival of cancer patients, however only the 20-30% of treated patients present clinical benefits. Toxicity represents the major cause of reduced dosage, delayed drug administration and therapy discontinuation. Hence in the context of multiple treatment possibilities, the identification of predictive markers of response and toxicity is a challenging approach for drug selection in order to obtain the best clinical benefit while minimizing the side effects...
October 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27806071/fosfomycin-addition-to-poly-d-l-lactide-coating-does-not-affect-prophylaxis-efficacy-in-rat-implant-related-infection-model-but-that-of-gentamicin-does
#10
Anil Gulcu, Alp Akman, Ahmet Fahir Demirkan, Ali Cagdas Yorukoglu, Ilknur Kaleli, Ferda Bir
Gentamicin is the preferred antimicrobial agent used in implant coating for the prevention of implant-related infections (IRI). However, the present heavy local and systemic administration of gentamicin can lead to increased resistance, which has made its future use uncertain, together with related preventive technologies. Fosfomycin is an alternative antimicrobial agent that lacks the cross-resistance presented by other classes of antibiotics. We evaluated the efficacy of prophylaxis of 10% fosfomycin-containing poly(D,L-lactide) (PDL) coated K-wires in a rat IRI model and compared it with uncoated (Control 1), PDL-coated (Control 2), and 10% gentamicin-containing PDL-coated groups with a single layer of coating...
2016: PloS One
https://www.readbyqxmd.com/read/27803174/the-third-signal-cytokine-il-12-rather-than-immune-checkpoint-inhibitors-contribute-to-the-functional-restoration-of-hepatitis-d-virus-specific-t-cells
#11
Thomas Schirdewahn, Jan Grabowski, Solomon Owusu Sekyere, Birgit Bremer, Anika Wranke, Sebastian Lunemann, Verena Schlaphoff, Janina Kirschner, Svenja Hardtke, Michael Peter Manns, Markus Cornberg, Heiner Wedemeyer, Pothakamuri Venkata Suneetha
BACKGROUND:  Hepatitis D virus (HDV) infection affects 15-20 million individuals world-wide and causes severely progressive hepatitis. It is unknown to what extent cellular immune responses contribute to liver disease and control of viral replication in HDV infection. METHODS:  Immune cell frequencies and phenotypes were determined in 49 HDV-infected patients, 25 HBV-monoinfected individuals and 18 healthy controls. T-cell proliferative and cytokine-producing capacities were analysed by stimulation with overlapping peptides spanning the large HDV antigen...
October 31, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27791434/a-comparative-study-of-pulsed-dye-laser-versus-long-pulsed-nd-yag-laser-treatment-in-recalcitrant-viral-warts
#12
Yo Sup Shin, Eun Byul Cho, Eun Joo Park, Kwang Ho Kim, Kwang Joong Kim
BACKGROUND: Viral warts are common infectious skin disease induced by human papillomavirus (HPV). But the treatment of recalcitrant warts is still challenging. OBJECTIVE: In this study, we compared the effectiveness of pulsed dye laser (PDL) and long pulsed Nd:YAG (LPNY) laser in the treatment of recalcitrant viral warts. METHODS: We retrospectively analyzed the medical records of patients with recalcitrant warts treated with laser therapy between January 2013 and February 2016...
November 15, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27790253/effect-of-dexamethasone-intraligamentary-injection-on-post-endodontic-pain-in-patients-with-symptomatic-irreversible-pulpitis-a-randomized-controlled-clinical-trial
#13
Payman Mehrvarzfar, Ehsan Esnashari, Reyhaneh Salmanzadeh, Mahta Fazlyab, Mahyar Fazlyab
INTRODUCTION: The aim of this randomized-controlled clinical trial was to assess the effect of intraligamentary (PDL) injection of dexamethasone on onset and severity of post-treatment pain in patients with symptomatic irreversible pulpitis. METHODS AND MATERIALS: A total number of 60 volunteers were included according to the inclusion criteria and were assigned to three groups (n=20). After administration of local anesthesia and before treatment, group 1 (control) PDL injection was done with syringe containing empty cartridge, while in groups 2 and 3 the PDL injection was done with 0...
2016: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/27769028/insulin-like-growth-factor-1-igf1-affects-proliferation-and-differentiation-and-wound-healing-processes-in-an-inflammatory-environment-with-p38-controlling-early-osteoblast-differentiation-in-periodontal-ligament-cells
#14
Jan Reckenbeil, Dominik Kraus, Helmut Stark, Birgit Rath-Deschner, Andreas Jäger, Matthias Wenghoefer, Jochen Winter, Werner Götz
OBJECTIVE: The objective of this study was to investigate effects of insulin-like growth factor 1 (IGF1) on proliferation, wound healing and differentiation processes of human periodontal ligament (PDL) cells under inflammatory conditions and whether the protective, anabolic effects of IGF1 can attenuate unfavorable effects of interleukin-1β (IL-1β). DESIGN: Inflammation was mimicked through cell stimulation with IL-1β. PDL cells were characterized in respect to the presence of components of the IGF system and the responsive potential on IL-1β incubation...
January 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/27746641/prospective-comparison-of-dual-wavelength-long-pulsed-755-nm-alexandrite-1-064-nm-neodymium-yttrium-aluminum-garnet-laser-versus-585-nm-pulsed-dye-laser-treatment-for-rosacea
#15
Hyun-Min Seo, Jung-In Kim, Han-Saem Kim, Young-Jun Choi, Won-Serk Kim
BACKGROUND: Rosacea treatments including oral/topical medications and laser therapy are numerous but unsatisfactory. OBJECTIVE: To compare the effectiveness of the dual wavelength long-pulsed 755-nm alexandrite/1,064-nm neodymium: yttrium-aluminum-garnet laser (LPAN) with that of 585-nm pulsed dye laser (PDL) for rosacea. METHODS: This was a randomized, single-blinded, comparative study. Full face received four consecutive monthly treatments with LPAN or PDL, followed-up for 6 months after the last treatment...
October 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27721403/cxcl2-mif-cxcr2-signaling-promotes-the-recruitment-of-myeloid-derived-suppressor-cells-and-is-correlated-with-prognosis-in-bladder-cancer
#16
H Zhang, Y-L Ye, M-X Li, S-B Ye, W-R Huang, T-T Cai, J He, J-Y Peng, T-H Duan, J Cui, X-S Zhang, F-J Zhou, R-F Wang, J Li
The accumulation of myeloid-derived suppressor cells (MDSCs) has been observed in solid tumors and is correlated with tumor progression; however, the underlying mechanism is still poorly understood. In this study, we identified a mechanism by which tumor cells induce MDSC accumulation and expansion in the bladder cancer (BC) microenvironment via CXCL2/MIF-CXCR2 signaling. Elevated expression of CXCL2 and MIF and an increased number of CD33(+) MDSCs were detected in BC tissues, and these increases were significantly associated with advanced disease stage and poor patient prognosis (P<0...
October 10, 2016: Oncogene
https://www.readbyqxmd.com/read/27707883/protein-kinase-ck2-controls-t-cell-polarization-through-dendritic-cell-activation-in-response-to-contact-sensitizers
#17
Marie de Bourayne, Yann Gallais, Zeina El Ali, Philippe Rousseau, Marie-Hélène Damiens, Claude Cochet, Odile Filhol, Sylvie Chollet-Martin, Marc Pallardy, Saadia Kerdine-Römer
Allergic contact dermatitis (ACD) represents a severe health problem with increasing worldwide prevalence. It is a T-cell-mediated inflammatory skin disease caused by chemicals present in the daily or professional environment. NiSO4 and 2,4-dinitrochlorobenzene (DNCB) are 2 chemicals involved in ACD. These contact sensitizers are known to induce an up-regulation of phenotypic markers and cytokine secretion in dendritic cells (DCs; professional APCs), leading to the generation of CD8(+) Tc1/Tc17 and CD4(+) Th1/Th17 effector T cells...
October 5, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27695530/nivolumab-in-the-treatment-of-advanced-renal-cell-carcinoma-clinical-trial-evidence-and-experience
#18
Alessia Mennitto, Paolo Grassi, Raffaele Ratta, Elena Verzoni, Michele Prisciandaro, Giuseppe Procopio
Renal cell carcinoma (RCC) is considered an immunogenic tumor with a prominent dysfunctional immune cell infiltrate, unable to control tumor growth. Cytokine-based immunotherapies, including interferon-α and interleukin-2, have been used for the treatment of metastatic RCC (mRCC). Long-term responses and complete remissions were observed, but durable clinical benefit efficacy in the overall population was limited and associated with significant toxicity. As a consequence, new generation agents targeting the vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) pathways replaced interferon alpha (IFN-α)...
October 2016: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/27638921/periodontal-tissue-regeneration-using-syngeneic-adipose-derived-stromal-cells-in-a-mouse-model
#19
Mathieu Lemaitre, Paul Monsarrat, Vincent Blasco-Baque, Pascale Loubières, Rémy Burcelin, Louis Casteilla, Valérie Planat-Bénard, Philippe Kémoun
: : Current treatment of periodontitis is still associated with a high degree of variability in clinical outcomes. Recent advances in regenerative medicine by mesenchymal cells, including adipose stromal cells (ASC) have paved the way to improved periodontal regeneration (PD) but little is known about the biological processes involved. Here, we aimed to use syngeneic ASCs for periodontal regeneration in a new, relevant, bacteria-induced periodontitis model in mice. Periodontal defects were induced in female C57BL6/J mice by oral gavage with periodontal pathogens...
September 16, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27631416/blockade-of-programmed-death-1-programmed-death-ligand-pathway-enhances-the-antitumor-immunity-of-human-invariant-natural-killer-t-cells
#20
Toshiko Kamata, Akane Suzuki, Naoko Mise, Fumie Ihara, Mariko Takami, Yuji Makita, Atsushi Horinaka, Kazuaki Harada, Naoki Kunii, Shigetoshi Yoshida, Ichiro Yoshino, Toshinori Nakayama, Shinichiro Motohashi
The role of invariant natural killer T (iNKT) cells in antitumor immunity has been studied extensively, and clinical trials in patients with advanced cancer have revealed a prolonged survival in some cases. In recent years, humanized blocking antibodies against co-stimulatory molecules such as PD-1 have been developed. The enhancement of T cell function is reported to improve antitumor immunity, leading to positive clinical effects. However, there are limited data on the role of PD-1/programmed death ligand (PDL) molecules in human iNKT cells...
December 2016: Cancer Immunology, Immunotherapy: CII
keyword
keyword
81567
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"