keyword
https://read.qxmd.com/read/33046436/deep-sedation-versus-general-anaesthesia-for-transcatheter-mitral-valve-repair-an-individual-patient-data-meta-analysis-of-observational-studies
#1
JOURNAL ARTICLE
Alexander Jobs, Simon Grund, Suzanne de Waha-Thiele, Jakob Ledwoch, Horst Sievert, Tienush Rassaf, Peter Luedike, Malte Kelm, Katharina Hellhammer, Patrick Horn, Ralf Westenfeld, Johannes Patzelt, Harald F Langer, Philipp Lurz, Steffen Desch, Ingo Eitel, Holger Thiele
AIMS: The aim of this meta-analysis was to compare general anaesthesia (GA) and deep sedation (DS) with regard to safety and length of intensive care unit (ICU) stay in patients undergoing percutaneous edge-to-edge mitral valve repair (PMVR). METHODS AND RESULTS: Four studies comparing GA and DS in patients undergoing PMVR were included in an individual patient data meta-analysis. Data were pooled after multiple imputation. The composite safety endpoint of all-cause death, stroke, pneumonia, or major to life-threatening bleeding occurred in 87 of 626 (13...
March 19, 2021: EuroIntervention
https://read.qxmd.com/read/33034814/clopidogrel-increases-risk-of-pneumonia-compared-with-aspirin-in-acute-ischemic-minor-stroke-patients
#2
JOURNAL ARTICLE
Zhangfeng Yu, Hua Zhou, Baoshuai Shan, Jianzhong Fu, Hao Zhu, Qian Feng, Rong Shen, Xing Jin
Antiplatelet agents may increase the risk of infections via suppressing platelet-mediated immune response. Here we assessed the contribution of clopidogrel versus aspirin to the development of pneumonia during an acute ischemic stroke admission. A retrospective cohort study was conducted of acute ischemic stroke patients who were admitted to our hospital from 2015 to 2018. Included patients received uninterrupted clopidogrel or aspirin therapy and did not take other antiplatelet agents throughout their stay...
July 2021: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/33031889/triggering-of-cardiovascular-disease-by-infection-type-the-atherosclerosis-risk-in-communities-study-aric
#3
JOURNAL ARTICLE
Logan T Cowan, Brian Buck, Jessica S Schwind, Pamela L Lutsey, James S Pankow, Kunihiro Matsushita, Junichi Ishigami, Kamakshi Lakshminarayan
INTRODUCTION: Acute infections are known triggers of cardiovascular disease (CVD) but how this association varies across infection types is unknown. We hypothesized while acute infections increase CVD risk, the strength of this association varies across infection types. METHOD: Acute coronary heart disease (CHD) and ischemic stroke cases were identified in the Atherosclerosis Risk in Communities Study (ARIC). ICD-9 codes from Medicare claims were used to identify cellulitis, pneumonia, urinary tract infections (UTI), and bloodstream infections...
February 15, 2021: International Journal of Cardiology
https://read.qxmd.com/read/32702435/ex-vivo-synthesized-cytokines-as-a-biomarker-of-stroke-associated-pneumonia
#4
JOURNAL ARTICLE
Elżbieta Gradek-Kwinta, Mateusz Czyzycki, Kazimierz Weglarczyk, Agnieszka Slowik, Maciej Siedlar, Tomasz Dziedzic
OBJECTIVES: We aimed to determine a profile of ex vivo released cytokines in patients with stroke-associated pneumonia (SAP) and to assess the clinical utility of individual cytokines and their combination as a biomarker of SAP. METHODS: We included 279 ischemic stroke patients (median age: 69 years; 41.6% women). We collected blood samples at day 3 after the onset of stroke and stimulated them ex vivo with lipopolysaccharide (LPS). We measured the LPS-induced cytokine concentrations (TNFα, IP-10, IL-1β, IL-6, IL-8, IL-10 and IL-12p70) as well as a plasma IL-6 level as a marker of systemic inflammation...
November 2020: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/32662845/association-of-do-not-resuscitate-patient-case-mix-with-publicly-reported-risk-standardized-hospital-mortality-and-readmission-rates
#5
JOURNAL ARTICLE
Benjamin D Pollock, Jeph Herrin, Matthew R Neville, Sean C Dowdy, Pablo Moreno Franco, Nilay D Shah, Henry H Ting
Importance: The Centers for Medicare and Medicaid Services's (CMS's) 30-day risk-standardized mortality rate (RSMR) and risk-standardized readmission rate (RSRR) models do not adjust for do-not-resuscitate (DNR) status of hospitalized patients and may bias Hospital Readmissions Reduction Program (HRRP) financial penalties and Overall Hospital Quality Star Ratings. Objective: To identify the association between hospital-level DNR prevalence and condition-specific 30-day RSMR and RSRR and the implications of this association for HRRP financial penalty...
July 1, 2020: JAMA Network Open
https://read.qxmd.com/read/32481512/impact-of-key-nicotinic-achr-subunits-on-post-stroke-pneumococcal-pneumonia
#6
JOURNAL ARTICLE
Sandra Jagdmann, Claudia Dames, Daniel Berchtold, Katarzyna Winek, Luis Weitbrecht, Andreas Meisel, Christian Meisel
Pneumonia is the most frequent severe medical complication after stroke. An overactivation of the cholinergic signaling after stroke contributes to immunosuppression and the development of spontaneous pneumonia caused by Gram-negative pathogens. The α7 nicotinic acetylcholine receptor (α7nAChR) has already been identified as an important mediator of the anti-inflammatory pathway after stroke. However, whether the α2, α5 and α9/10 nAChR expressed in the lung also play a role in suppression of pulmonary innate immunity after stroke is unknown...
May 28, 2020: Vaccines
https://read.qxmd.com/read/32474143/comparative-long-term-outcomes-of-patients-with-aorto-iliac-occlusive-disease-limited-to-common-iliac-arteries-treated-with-endarterectomy-versus-bypass
#7
JOURNAL ARTICLE
Jesse Manunga, Aleem Mirza, Nedaa Skeik, Larissa Stanberry, Senthil Jayarajan, Timothy M Sullivan
OBJECTIVE: To compare outcomes of patients with aorto-iliac occlusive disease (AIOD) limited to the common iliac territory and treated by either aortoiliac thromboendarterectomy (AIE) or aorto-bi-iliac bypass grafting (ABIB). METHODS: A single center, retrospective analysis of consecutive patients with AIOD treated either with AIE or ABIB between 2010 and 2019 from a prospective database. Patients with disease extending to the external iliac or common femoral arteries were excluded...
May 28, 2020: Annals of Vascular Surgery
https://read.qxmd.com/read/32407279/serum-albumin-as-a-potential-predictor-of-pneumonia-after-an-acute-ischemic-stroke
#8
JOURNAL ARTICLE
Xue Yang, Lu Wang, Lukai Zheng, Jiongxing Wu, Junfeng Liu, Zilong Hao, Shihong Zhang, Bo Wu, Ming Liu, Deren Wang
BACKGROUND: Serum albumin level is associated with infection after stroke, but whether albumin predicts post-stroke pneumonia is unclear. The potential relationship between albumin level and pneumonia in patients with acute ischemic stroke (AIS) was evaluated in this study. METHODS: A consecutive sample of 798 AIS patients who were admitted to West China Hospital within 24 h after onset, from the year 2017 to 2018, were retrospectively analyzed. Blood was collected on admission and assayed for serum albumin...
2020: Current Neurovascular Research
https://read.qxmd.com/read/32117536/lupus-and-perioperative-complications-in-elective-primary-total-hip-or-knee-arthroplasty
#9
JOURNAL ARTICLE
Keith T Aziz, Matthew J Best, Richard L Skolasky, Karthik E Ponnusamy, Robert S Sterling, Harpal S Khanuja
Background: The number of patients with systemic lupus erythematosus (herein, lupus) undergoing total hip arthroplasty (THA) or total knee arthroplasty (TKA) is increasing. There is disagreement about the effect of lupus on perioperative complication rates. We hypothesized that lupus would be associated with higher complication rates in patients who undergo elective primary THA or TKA. Methods: Records of more than 6.2 million patients from the National Inpatient Sample who underwent elective primary THA or TKA from 2000 to 2009 were reviewed...
March 2020: Clinics in Orthopedic Surgery
https://read.qxmd.com/read/32033891/comparison-of-glycemic-variability-indices-blood-glucose-risk-index-and-coefficient-of-variation-in-predicting-adverse-outcomes-for-patients-undergoing-cardiac-surgery
#10
JOURNAL ARTICLE
Valluvan Rangasamy, Xinling Xu, Ammu Thampi Susheela, Balachundhar Subramaniam
OBJECTIVES: Fluctuations in blood glucose (glycemic variability) increase the risk of adverse outcomes. No universally accepted tool for glycemic variability exists during the perioperative period. The authors compared 2 measures of glycemic variability-(1) coefficient of variation (CV) and (2) the Blood Glucose Risk Index (BGRI)-in predicting adverse outcomes after cardiac surgery. DESIGN: Prospective, observational study. SETTING: Single-center, teaching hospital...
July 2020: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/32001982/risk-factors-for-readmission-within-thirty-days-following-revision-total-hip-arthroplasty
#11
JOURNAL ARTICLE
Colin K Cantrell, Henry A DeBell, Eva J Lehtonen, Harshadkumar A Patel, Haley M McKissack, Gerald McGwin, Ashish Shah, Sameer Naranje
BACKGROUND: The number of total hip arthroplasties (THA) being performed has been steadily increasing for decades. With increased primary THA surgical volume, revision THA numbers are also increasing at a steady pace. With the aging, increasingly comorbid patient populations and newly imposed financial penalties for hospitals with high readmission rates, refining understanding of factors influencing readmission following THA is a research priority. We hypothesize that numerous preoperative medical comorbidities and postoperative medical complications will emerge as significant positive risk factors for 30-day readmission...
January 2020: Journal of Clinical Orthopaedics and Trauma
https://read.qxmd.com/read/31996724/associations-between-untraditional-risk-factors-pneumonia-lung-cancer-and-hospital-fatality-among-hypertensive-men-in-guangzhou-downtown
#12
JOURNAL ARTICLE
Yuechun Shen, Yuelin Chen, Zheng Huang, Junyao Huang, Xinchun Li, Zuojun Tian, Jun Li
Mortality of primary hypertension is high worldwide. Whether untraditional factors exist in modern life and affect the mortality is not well studied. The aim of the study was to evaluate the risk factors for fatality rate of hypertensive men in downtown area. A cross-sectional study was performed on hypertensive men, who were hospitalized into our hospital and lived in eligible urban areas. The characteristics of the patients and factors for the fatality were analyzed and of the risks or the contributors on the status were investigated...
January 29, 2020: Scientific Reports
https://read.qxmd.com/read/31866129/dysphagia-and-tube-feeding-after-stroke-are-associated-with-poorer-functional-and-mortality-outcomes
#13
JOURNAL ARTICLE
Juli Thomaz Souza, Priscila Watson Ribeiro, Sérgio Alberto Rupp de Paiva, Suzana Erico Tanni, Marcos Ferreira Minicucci, Leonardo Antônio Mamede Zornoff, Bertha Furlan Polegato, Silméia Garcia Zanati Bazan, Gabriel Pinheiro Modolo, Rodrigo Bazan, Paula Schmidt Azevedo
BACKGROUND & AIMS: Stroke is the leading cause of disability in adult life. Oropharyngeal dysphagia occurs in 65-90% of patients, and its identification in the acute phase of stroke can prevent complications. The aim of this study was to verify whether oropharyngeal dysphagia during stroke hospitalization is associated with functional capacity, as assessed by the modified Rankin Scale (mRs), and mortality 90 days after stroke. MATERIALS AND METHODS: A prospective cohort study evaluating 201 patients hospitalized in the Stroke Unit was carried out...
September 2020: Clinical Nutrition
https://read.qxmd.com/read/31814729/scoring-of-post-stroke-pneumonia-in-uttaradit-hospital
#14
JOURNAL ARTICLE
Nichakarn Leangpanich, Yanin Chuphanitsakun, Kanyaros Pakaranodom, Kunlachat Kerdjarern, Watcharapol Poonual
Background: Stroke is a disease which occurs when the blood supply to the brain is interrupted, depriving brain tissue of oxygen, resulting in cell death. The symptoms of stroke include: numbness, paraplegia, dysarthria, ataxia, etc. The most common complication is infection. The highest death rates among hospitalized stroke patients are from pneumonia. Objective: To develop a score for predicting post-stroke pneumonia infection and identify risk factors for patients with post-stroke pneumonia...
2019: Journal of Multidisciplinary Healthcare
https://read.qxmd.com/read/31801183/elder-abuse-and-associated-factors-in-eastern-romania
#15
JOURNAL ARTICLE
Ioana Dana Alexa, Adina Carmen Ilie, Anca Iuliana Pislaru, Aliona Dronic, Ovidiu Gavrilovici, Teodora Alexa-Stratulat, Ramona Stefaniu, Ioana Sandu, Catalina Nuta, Anna Marie Herghelegiu
BACKGROUND: This article explores elder abuse in a hospitalised population. We wanted to identify details related to psychological and emotional abuse in the older population in our region and to determine the importance of the Elderly Abuse Suspicion Index (EASI© ) in comprehensive geriatric assessments. METHODS: This cross-sectional study conducted between March 2015 and May 2016 included 386 consecutive hospitalised patients over 65 years of age. All patients underwent a geriatric assessment, data were collected about their medical history, and the EASI© was administered to each...
March 2020: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://read.qxmd.com/read/31757216/in-line-filtration-of-intravenous-infusion-may-reduce-organ-dysfunction-of-adult-critical-patients
#16
JOURNAL ARTICLE
Elke Schmitt, Patrick Meybohm, Eva Herrmann, Karin Ammersbach, Raphaela Endres, Simone Lindau, Philipp Helmer, Kai Zacharowski, Holger Neb
BACKGROUND: The potential harmful effects of particle-contaminated infusions for critically ill adult patients are yet unclear. So far, only significant improved outcome in critically ill children and new-borns was demonstrated when using in-line filters, but for adult patients, evidence is still missing. METHODS: This single-centre, retrospective controlled cohort study assessed the effect of in-line filtration of intravenous fluids with finer 0.2 or 1.2 μm vs 5...
November 22, 2019: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/31735079/risk-stratification-model-for-post-stroke-pneumonia-in-patients-with-acute-ischemic-stroke
#17
JOURNAL ARTICLE
Ya-Wen Kuo, Yen-Chu Huang, Meng Lee, Tsong-Hai Lee, Jiann-Der Lee
BACKGROUND: Post-stroke pneumonia (PSP) has been implicated in the morbidity, mortality, and increased medical costs after acute ischemic stroke. AIM: The aim of this study was to develop a prediction model for PSP in patients with acute ischemic stroke. METHODS: A retrospective, case-control, secondary analysis study was conducted using data for 10,034 patients with ischemic stroke who presented to the hospital within 24 hours of onset of stroke symptoms...
August 2020: European Journal of Cardiovascular Nursing
https://read.qxmd.com/read/31629312/predicting-post-stroke-pneumonia-using-deep-neural-network-approaches
#18
JOURNAL ARTICLE
Yanqiu Ge, Qinghua Wang, Li Wang, Honghu Wu, Chen Peng, Jiajing Wang, Yuan Xu, Gang Xiong, Yaoyun Zhang, Yingping Yi
BACKGROUND AND PURPOSE: Pneumonia is a common complication after stroke, causing an increased length of hospital stay and death. Therefore, the timely and accurate prediction of post-stroke pneumonia would be highly valuable in clinical practice. Previous pneumonia risk score models were often built on simple statistical methods such as logistic regression. This study aims to investigate post-stroke pneumonia prediction models using more advanced machine learning algorithms, specifically deep learning approaches...
December 2019: International Journal of Medical Informatics
https://read.qxmd.com/read/31590645/braden-scale-for-assessing-pneumonia-after-acute-ischaemic-stroke
#19
JOURNAL ARTICLE
Yunlong Ding, Yazhou Yan, Jiali Niu, Yanrong Zhang, Zhiqun Gu, Ping Tang, Yan Liu
BACKGROUND: The prevention of pneumonia is critical for patients with acute ischaemic stroke (AIS). The six subscales in the Braden Scale seem to be related to the occurrence of pneumonia. We aimed to evaluate the feasibility of using the Braden Scale to predict the occurrence of pneumonia after AIS. METHODS: We studied a series of consecutive patients with AIS who were admitted to the hospital. The cohort was subdivided into pneumonia and no pneumonia groups. The scores on the Braden Scale, demographic characteristics and clinical characteristics were obtained and analysed by statistical comparisons between the two groups...
October 7, 2019: BMC Geriatrics
https://read.qxmd.com/read/31475211/mitral-valve-replacement-via-minimally-invasive-totally-thoracoscopic-surgery-versus-traditional-median-sternotomy-a-propensity-score-matched-comparative-study
#20
JOURNAL ARTICLE
Jian Liu, Bo Chen, Yu-Yuan Zhang, Liang-Zheng Fang, Bin Xie, Huan-Lei Huang, Jing Liu, Cong Lu, Wen-Da Gu, Zhao Chen, Jie-Xu Ma, Hai-Yun Yuan, Ji-Mei Chen, Jian Zhuang, Hui-Ming Guo
Background: To compare surgical outcomes after mitral valve replacement via either minimally invasive thoracoscopic (MIs) or traditional median sternotomy (MS) surgery and determine the short- and mid-term clinical outcomes of the MI approach. Methods: All patients who received either MIs (n=405) or MS (n=691) mitral valve replacement surgery at the Guangdong Cardiovascular Institute between January 2012 and July 2015 were analyzed for outcome differences due to surgical approach using propensity score matching...
July 2019: Annals of Translational Medicine
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