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https://www.readbyqxmd.com/read/28808600/simultaneous-determination-of-11-compounds-in-gualou-guizhi-granule-and-pharmacokinetics-study-by-uplc-ms-ms
#1
Chengtao Sun, Wen Xu, Yuqin Zhang, Lishuang Yu, Miao Ye, Kedan Chu, Wei Xu, Yu Lin
A rapid and sensitive ultrafast performance liquid chromatography-tandem mass spectrometry method (UPLC-MS/MS) was developed for the simultaneous determination of 11 compounds in Gualou Guizhi Granule (GLGZG), including liquiritin, isoliquiritin, liquirtin apioside, isoliquiritin apioside, liquiritigenin, isoliquiritigenin, glycyrrhizic acid, glycyrrhetinic acid, paeoniflorin, albiflorin, and paeoniflorin sulfonate in rat plasma. UPLC-MS/MS assay with negative ion mode was performed on a Waters CORTECS C18 (2...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28807848/hydroalcoholic-extract-from-bark-of-persea-major-meisn-l-e-kopp-lauraceae-exerts-antiulcer-effects-in-rodents-by-the-strengthening-of-the-gastric-protective-factors
#2
Lincon Bordignon Somensi, Thaise Boeing, Benhur Judah Cury, Viviane Miranda Bispo Steimbach, Rivaldo Niero, Lauro Mera de Souza, Luisa Mota da Silva, Sérgio Faloni de Andrade
ETHOPHARMACOLOGICAL RELEVANCE: The Persea major (Meisn.) L.E. Kopp (Lauraceae) (botanical synonym: Persea pyrifolia (D. Don) Spreng, Persea pyrifolia Nees and Mart., Persea cordata var. major (Meisn.) Mez and Persea willdenovii Kosterm) is a medicinal plant native in the south of Brazil, where is popularly known as Pau de Andrade, Maçaranduba or Abacate-do-Mato. Its barks are commonly used to prepare an infusion which is administered orally or topically to treat ulcers and wounds, respectively...
August 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28807230/global-identification-of-chemical-constituents-and-rat-metabolites-of-si-miao-wan-by-liquid-chromatography-electrospray-ionization-quadrupole-time-of-flight-mass-spectrometry
#3
Jin-Jin Lu, Xue-Wen Hu, Ping Li, Jun Chen
Si-Miao-Wan (SMW), a tradiational Chinese medicinal formula consisting of Atractylodis Rhizoma, Phellodendri Chinensis Cortex, Coicis Semen, and Achyranthis Bidentatae Radix, has been used for the treatment of gout and gouty arthritis for many years. In the present study, a liquid chromatography quadrupole-time-of-flight mass spectrometry (LC-Q-TOF/MS) method was established to identify the multiple constituents of SMW and its metabolites in rat biological samples after oral administration. A total of 48 compounds in SMW, including 21 alkaloids, 12 organic acids, 2 terpenes, 3 lactones, 2 phytosterols, and 8 other compounds, were tentatively characterized with the diagnostic-ion filtering strategy...
July 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28806568/a-simple-high-performance-liquid-chromatography-mass-spectrometry-method-for-therapeutic-drug-monitoring-of-isavuconazole-and-four-other-antifungal-drugs-in-human-plasma-samples
#4
Giovanna Fatiguso, Fabio Favata, Ilaria Zedda, Amedeo De Nicolò, Jessica Cusato, Valeria Avataneo, Giovanni Di Perri, Antonio D'Avolio
Triazoles chanced the prevention and treatment of invasive fungal infections, but their pharmacokinetic properties are still unclear. In particular, isavuconazole (ISC) is a new broad-spectrum antifungal triazole approved in 2015 as first-line treatment for intravenous and oral use against invasive aspergillosis and for mucormycosis. Nowadays, the optimal management of the treatments with triazoles requires the use of Therapeutic Drug Monitoring (TDM), in order to prevent sub-therapeutic or toxic concentrations...
August 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28802242/an-lc-ms-ms-method-for-simultaneous-determination-of-nine-steroidal-saponins-from-paris-polyphylla-var-in-rat-plasma-and-its-application-to-pharmacokinetic-study
#5
Guangyi Yang, Wei Lu, Meng Pan, Chenning Zhang, Yuan Zhou, Pei Hu, Ming Hu, Gao Song
Paris polyphylla var is an herbal plant herb widely used in Traditional Chinese Medicine. The purpose of this study is to develop an Ultra Performance Liquid Chromatography-tandem mass spectrometer (UPLC-MS) method to quantify the major components (i.e., nine saponins) from P. polyphylla in plasma samples. A UItra BiPh column (100×2.1mm, 5μm) was used with acetonitrile/0.1% formic acid in water as mobile phases. The analytes were quantified using a Waters XEVO TQ mass spectrometer via multiple reaction monitoring (MRM) with positive scan mode...
August 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28800124/uplc-qtof-ms-identification-of-the-chemical-constituents-in-rat-plasma-and-urine-after-oral-administration-of-rubia-cordifolia-l-extract
#6
Zuoliang Zheng, Shengqing Li, Yuping Zhong, Ruoting Zhan, Yan Yan, Huafeng Pan, Ping Yan
An effective ultra-performance liquid chromatography coupled with the quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF/MS) method was developed for analysing the chemical constituents in rat plasma and urine after the oral administration of Rubia cordifolia L. extract. Under the optimized conditions, nine of 11 prototypes in rat plasma and four prototypes in urine were identified or characterized by comparing the retention time, accurate mass, fragmentation patterns, reference compounds, and literature data...
August 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28793175/identification-of-the-constituents-and-metabolites-in-rats-after-oral-administration-of-zi-shen-formula-by-uplc-q-tof-ms-combined-pattern-recognition-analysis
#7
Yanchao Zheng, Yidan Zhang, Shihan Geng, Mengxi Xu, Qingshen Yin, Lili Song, Pengwei Zhuang, Yanjun Zhang
An ultra high-performance liquid chromatography mass spectrometry method was established to detect and identify the chemical constituents of Zi Shen Formula (ZSF) and its metabolites in serum, urine and feces, after oral administration into rats. A total of 68 compounds were characterized in ZSF extracts. In vivo, 38 prototype components and 32 metabolites of ZSF were tentatively identified in rat serum, urine and feces. 7 metabolic pathways including demethylation, hydroxylation, oxidation, sulfation, glucuronidation, methylation, de-caffeoyl were proposed to involve in the generation of these metabolites...
August 9, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28783562/simultaneous-determination-of-paeonilactone-a-and-paeonilactone-b-in-rat-plasma-after-oral-administration-of-albiflorin-by-uplc-tof-ms-following-picolinoyl-derivatization
#8
Zhigang Wang, Shuhan Tang, Masao Hattori, Hailong Zhang, Xiuhong Wu
A new highly sensitive analytical method was developed to investigate the in vivo metabolism of albiflorin, one of the most principal components in traditional Chinese medicine. After hydrolyzation with sulfatase, the main metabolites paeonilactone A and paeonilactone B of paeoniflorin in rat plasma were successfully detected for the first time by liquid chromatography mass spectrometry following picolinoyl derivatization. Borneol was used as the internal standard compound to quantify paeonilactone A and paeonilactone B in rat plasma...
July 29, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28778039/simultaneous-quantification-six-active-compounds-in-rat-plasma-by-uplc-ms-ms-and-its-application-to-a-pharmacokinetic-study-of-pien-tze-huang
#9
Wen Xu, Yiping Zhang, Caijie Zhou, Yanni Tai, Xiaoqing Zhang, Jie Liu, Mei Sha, Mingqing Huang, Yanlin Zhu, Jun Peng, Jin-Jian Lu
Pien-Tze-Huang (PZH) is a popular traditional Chinese medicine (TCM) formula in China, but its pharmacokinetics has not been investigated yet. To better study the pharmacokinetic behaviors of PZH, an optimal ultra-performance liquid chromatography with triple quadrupole mass spectrometry (UPLC-MS/MS) method was developed for rapid quantification of six compounds (notoginsenoside R1, ginsenosides Re, Rg1, Rb1, Rd, and muscone) in rat plasma after oral administration of PZH. All analytes were extracted by protein precipitation with acetonitrile and separated on a Waters Acquity Cortecs C18 column within 3...
July 23, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28769792/danshen-chuanxiong-honghua-ameliorates-cerebral-impairment-and-improves-spatial-cognitive-deficits-after-transient-focal-ischemia-and-identification-of-active-compounds
#10
Xianhua Zhang, Wan Zheng, Tingrui Wang, Ping Ren, Fushun Wang, Xinliang Ma, Jian Wang, Xi Huang
Previously, we only apply a traditional Chinese medicine (TCM) Danshen-Chuanxiong-Honghua (DCH) for cardioprotection via anti-inflammation in rats of acute myocardial infarction by occluding coronary artery. Presently, we select not only DCH but also its main absorbed compound ferulic acid (FA) for cerebra protection via similar action of mechanism above in animals of the transient middle cerebral artery occlusion (tMCAO). We investigated whether oral administration of DCH and FA could ameliorate MCAO-induced brain lesions in animals...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28759935/a-rapid-and-sensitive-uplc-ms-ms-method-for-quantification-of-bruceantinol-in-rat-plasma-and-its-application-to-a-pharmacokinetic-study
#11
Jun Li, Dayong Zheng, Bixian Zhen, Yunfeng Sun, Fen Chen, Kaixuan Zhan, Ning Wei, Lide Zhang
Bruceantinol (BOL), a quassinoid compound isolated from the fruits of Brucea javanica, has been reported to have cytotoxic and antibacterial effects. In this study, a rapid, sensitive, and specific ultra-performance liquid chromatography with tandem mass spectrometry (UPLC-MS/MS) method was developed for the quantitative determination of BOL in rat plasma. The samples were treated by simple liquid-liquid extraction with ethyl acetate and separated on an UPLC BEH C18 column (2.1 mm × 50 mm) using a 3-min gradient elution scheme, which consists of water (0...
July 31, 2017: Planta Medica
https://www.readbyqxmd.com/read/28755076/comparative-pharmacokinetics-of-three-phenylpropanoids-in-rat-plasma-after-oral-administration-of-ramulus-cinnamomi-and-ramulus-cinnamomi-ephedrae-herba-herb-couple-extract
#12
Ping Wei, Qing-Fa Tang, Hui-Ling Huo, Fei-Long Chen, Shuai Song, Xue-Feng Xing, Jia-Bo Luo
OBJECTIVE: To investigate the pharmacokinetic characteristics of three phenylpropanoids (cinnamic acid, cinnamic alcohol and coumarin) in Ramulus Cinnamomi (GZ) and Ramulus Cinnamomi-Ephedrae Herba (MH) herb-couple (GZMH). METHODS: Twelve male Sprague-Dawley rats were randomly and equally divided into the GZ and GZMH herb-couple groups. Blood samples were collected at 0, 0.08, 0.25, 0.5, 0.75, 1.5, 3, 4, 6, 8, 12, 24, 36 and 48 h after oral administration. The three phenylpropanoids in rat plasma were quantified using an ultra-performance liquid-chromatography with tandem mass spectrometry (UPLC-MS/MS) method for pharmacokinetic study...
July 28, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28753987/chemical-analysis-of-astragali-complanati-semen-and-its-hypocholesterolemic-effect-using-serum-metabolomics-based-on-gas-chromatography-mass-spectrometry
#13
Tung Ting Sham, Huan Zhang, Daniel Kam Wah Mok, Shun Wan Chan, Jianhong Wu, Songyun Tang, Chi On Chan
The hypocholesterolemic protective effect of the dried seed of Astragalus complanatus (ACS) was investigated in rats fed with normal diet, high cholesterol diet (HCD), and HCD plus 70% ethanol extract of ACS (600 mg/kg/day) by oral gavage for four weeks. ACS extract was tested to be rich in antioxidants, which may be contributed to its high content of phenolic compounds. Consumption of ACS remarkably suppressed the elevated total cholesterol (p < 0.01) and LDL-C (p < 0.001) induced by HCD. Chemical constituents of ACS extract were analyzed by ultra-performance liquid chromatography coupled with electrospray ionization orbitrap mass spectrometry and the results showed that the ACS extract mainly consisted of phenolic compounds including flavonoids and flavonoid glycosides...
July 21, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28750774/effects-of-sub-chronic-exposure-to-terbuthylazine-on-dna-damage-oxidative-stress-and-parent-compound-metabolite-levels-in-adult-male%C3%A2-rats
#14
Blanka Tariba Lovaković, Alica Pizent, Vilena Kašuba, Nevenka Kopjar, Vedran Micek, Gordana Mendaš, Marija Dvoršćak, Anja Mikolić, Mirta Milić, Suzana Žunec, Ana Lucić Vrdoljak, Davor Želježić
Terbuthylazine is a selective pre- and post-emergency chloro-triazine herbicide used for a broad spectrum of weed control. We evaluated the potential of low doses of terbuthylazine to induce oxidative stress and cytogenetic damage in peripheral blood samples of adult male Wistar rats. Following 28-day repeated oral exposure at 0.004 mg/kg b.w./day, 0.4 mg/kg b.w./day and 2.29 mg/kg b.w./day, parameters of lipid peroxidation, total antioxidant capacity, and activities of antioxidant enzymes were measured in blood samples...
July 24, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28744886/development-and-validation-of-an-lc-ms-ms-method-for-the-simultaneous-quantification-of-seven-constituents-in-rat-plasma-and-application-in-a-pharmacokinetic-study-of-the-zaoren-anshen-prescription
#15
Ajing Zhao, Li Zhang, Rong Li, Jiao Shang, Huihui Yi, Yuan Wang, Dian Zhang, Shixiang Wang, Minfeng Fang
A sensitive, specific and accurate liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of seven constituents of the Zaoren Anshen prescription (ZAP) in rat plasma after oral administration of the ZAP: spinosin, salvianic acid A, 6"'-feruloylspinosin, protocatechualdehyde, salvianolic acid B, schisandrin and deoxyschisandrin. The plasma samples and the internal standard (IS) sulfamethoxazole were extracted using acetonitrile. Chromatographic separation was performed with an Agilent HC-C18 column using a gradient elution profile and a mobile phase consisting of 0...
July 26, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28743078/metabolite-identification-of-azd8055-in-sprague-dawley-rats-after-a-single-oral-administration-using-ultra-performance-liquid-chromatography-and-mass-spectrometry
#16
Md Mamunur Rashid, Hyun-A Oh, Hyunbeom Lee, Byung Hwa Jung
AZD8055 is an ATP-competitive specific dual mTOR inhibitor and exhibited potent antitumor activity on several types of solid tumors. However, the metabolism of AZD8055 in the body still remains unknown. In this study, metabolite identification of AZD8055 was performed using ultra high-performance liquid chromatography-ion trap mass spectrometry (UHPLC-IT-MS) through both in vitro and in vivo approaches using rat liver microsomes (RLMs) and rat plasma, urine and feces, respectively. A total of eight putative metabolites (five phase I and three phase II) were identified, and a tentative metabolic pathway was suggested for the first time...
July 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28734962/analyzing-the-hepatoprotective-effect-of-the-swertia-cincta-burkillextract-against-anit-induced-cholestasis-in-rats-by-modulating-the-expression-of-transporters-and-metabolic-enzymes
#17
Lili Xu, Tingting Sheng, Xiaolong Liu, Tong Zhang, Zhengtao Wang, Han Han
ETHNOPHARMACOLOGICAL RELEVANCE: Swertia cincta Burkill was traditionally used for treating jaundice and various types of chronic and acute hepatitis in Yunnan and Tibet in China for hundreds of years. This study aims to investigate the protective effect of S. cincta Burkill (ESC) extract on alpha-naphthylisothiocyanate (ANIT)-induced hepatotoxicity and cholestasis in rats. MATERIALS AND METHODS: Crude extracts were prepared using 90% ethanol and by vacuum drying...
July 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28719377/stability-of-acetazolamide-baclofen-dipyridamole-mebeverine-hydrochloride-propylthiouracil-quinidine-sulfate-and-topiramate-oral-suspensions-in-syrspend-sf-ph4
#18
Anderson de Oliveira Ferreira, Hudson Polonini, Sharlene Loures da Silva, Natália Cristina Buzinari Aglio, Jordana Abreu, Brandão Marcos Antônio Fernandes
The objective of this study was to evaluate the stability of 7 commonly used active pharmaceutical ingredients compounded in oral suspensions using an internationally used suspending vehicle (SyrSpend SF PH4): acetazolamide 25.0 mg/mL, baclofen 10.0 mg/mL, dipyridamole 10.0 mg/mL, mebeverine hydrochloride 10.0 mg/mL, propylthiouracil 5.0 mg/mL, quinidine sulfate 10.0 mg/mL, and topiramate 5.0 mg/mL. All suspensions were stored both at controlled refrigerated (2°C to 8°C) and room temperature (20°C to 25°C)...
July 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28719376/stability-of-spironolactone-oral-suspension-in-pcca-base-suspendit
#19
Richard Graves, Kelly V Phan, Levon A Bostanian, Tarun K Mandal, Yashoda V Pramar
Spironolactone (Aldactone) is a potassium-sparing diuretic used to treat hypertension and heart failure and may also be used to treat edema resulting from kidney disease, low potassium levels, or excess aldosterone. No commercial liquid dosage form of spironolactone exists. An extemporaneously compounded suspension from pure drug powder or commercial tablets would provide an alternative option to meet unique patient needs. The purpose of this study was to determine the physicochemical stability of spironolactone in the PCCA base SuspendIt...
July 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28719374/physical-and-chemical-stability-of-budesonide-mucoadhesive-oral-suspensions-mucolox
#20
Kendice Ip, Maria Carvalho, Ashley Shan, Daniel Banov
Budesonide is a corticosteroid that has been shown effective in the treatment of eosinophilic esophagitis, but there are currently no commercial medicines to treat this chronic allergic/immune condition, despite its prevalence in the U.S. Therefore, pharmaceutical compounding is the alternative choice to meet the therapeutic need of eosinophilic esophagitis patients. Two budesonide mucoadhesive oral suspensions (1 mg/10 mL and 2 mg/10 mL) were developed using the compounding vehicle MucoLox, a proprietary mucoadhesive polymer blend that promotes mucosal adhesion...
July 2017: International Journal of Pharmaceutical Compounding
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