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Oral liquid compounding

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https://www.readbyqxmd.com/read/28069869/determination-of-%C3%A2-9-tetrahydrocannabinol-thc-11-hydroxy-thc-11-nor-9-carboxy-thc-and-cannabidiol-in-human-plasma-using-gas-chromatography-tandem-mass-spectrometry
#1
David M Andrenyak, David E Moody, Matthew H Slawson, Daniel S O'Leary, Margaret Haney
Two marijuana compounds of particular medical interest are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). A gas chromatography-tandem mass spectrometry (GC-MS-MS) method was developed to test for CBD, THC, hydroxy-THC (OH-THC) and carboxy-THC (COOH-THC) in human plasma. Calibrators (THC and OH-THC, 0.1 to 100; CBD, 0.25 to 100; COOH-THC, 0.5-500 ng/mL) and controls (0.3, 5 and 80 ng/mL, except COOH-THC at 1.5, 25 and 400 ng/mL) were prepared in blank matrix. Deuterated (d3) internal standards were added to 1-mL samples...
January 8, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28062204/impact-of-formulation-properties-and-process-parameters-on-the-dispensing-and-depositioning-of-drug-nanosuspensions-using-micro-valve-technology
#2
Bastian Bonhoeffer, Arno Kwade, Michael Juhnke
Flexible manufacturing processes with continuously adjustable dose strengths are considered particularly innovative and interesting for applications in personalized medicine, continuous manufacturing or early drug development. A piezo-actuated micro-valve has been investigated for the dispensing and depositioning of drug nanosuspensions onto substrates to facilitate the manufacturing of solid oral dosage forms. The investigated micro-valve has been characterized regarding dispensing behavior, mass flow, accuracy and robustness...
January 3, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28054450/simultaneous-analysis-of-bisphenol-a-based-compounds-and-other-monomers-leaching-from-resin-based-dental-materials-by-uhplc-ms-ms
#3
Eveline Putzeys, Stevan M Cokic, Hui Chong, Mario Smet, Jeroen Vanoirbeek, Lode Godderis, Bart Van Meerbeek, Kirsten L Van Landuyt, Radu Corneliu Duca
Resin-based dental materials have raised debates concerning their safety and biocompatibility, resulting in a growing necessity of profound knowledge on the quantity of released compounds into the oral cavity. In this context, the aim of this study was to develop a comprehensive and reliable procedure based on liquid chromatography with mass spectrometry for the simultaneous analysis of various leached compounds (including bisphenol A based compounds) in samples from in vitro experiments. Different experiments were performed to determine the optimal analytical parameters, comprising mass spectrometry parameters, chromatographic separation conditions and sample preparation...
January 5, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28039926/quantification-of-highly-selective-sigma-1-receptor-antagonist-cm304-using-liquid-chromatography-tandem-mass-spectrometry-and-its-application-to-a-pre-clinical-pharmacokinetic-study
#4
Bonnie A Avery, Pradeep K Vuppala, Seshulatha Jamalapuram, Abhisheak Sharma, Christophe Mesangeau, Frederick T Chin, Christopher R McCurdy
An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for quantification CM304, a novel and highly selective sigma-1 receptor antagonist that has recently entered into human clinical trials. A structural analogue of CM304, SN56, was used as the internal standard (IS). Chromatographic separation was achieved on an Acquity UPLC(TM) BEH C18 (1.7 µm, 2.1 mm × 50 mm) column using a mobile phase [water : methanol (0.1 %v/v formic acid; 50 : 50, %v/v)] at a flow rate of 0...
December 30, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28033584/identification-bioactivity-evaluation-and-pharmacokinetics-of-multiple-components-in-rat-serum-after-oral-administration-of-xian-ling-gu-bao-capsule-by-ultra-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-tandem-mass-spectrometry
#5
Zhi-Hong Yao, Zi-Fei Qin, Liang-Liang He, Xin-Luan Wang, Yi Dai, Ling Qin, Frank J Gonzalez, Wen-Cai Ye, Xin-Sheng Yao
The Xian-Ling-Gu-Bao capsule (XLGB) is a famous traditional Chinese medicine prescription (TCMP), which has proven effective in osteoporosis treatment. However, due to the lack of a dynamic XLGB profile, the in vivo pharmacokinetics of multiple bioactive components within this medicine remains unknown. In the present study, ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS) identified a total of eighteen prototypes (using reference standards) in rat serum after oral administration of XLGB...
January 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28029115/development-of-orally-administered-%C3%AE-tocotrienol-gt3-nanoemulsion-for-radioprotection
#6
Grace A Ledet, Shukla Biswas, Vidya P Kumar, Richard A Graves, Demaurian M Mitchner, Taylor M Parker, Levon A Bostanian, Sanchita P Ghosh, Tarun K Mandal
The purpose of this study was two-fold: (1) to formulate γ-tocotrienol (GT3) in a nanoemulsion formulation as a prophylactic orally administered radioprotective agent; and (2) to optimize the storage conditions to preserve the structural integrity of both the formulation and the compound. γ-tocotrienol was incorporated into a nanoemulsion and lyophilized with lactose. Ultra performance liquid chromatography-mass spectroscopy (UPLC-MS) was used to monitor the chemical stability of GT3 over time, the particle size and ζ potential, and scanning electron microscopy (SEM) were used to study the physical stability of the nanoemulsion...
December 24, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28001462/comparative-pharmacokinetics-between-madecassoside-and-asiaticoside-presented-in-a-standardised-extract-of-centella-asiatica-eca-233-and-their-respective-pure-compound-given-separately-in-rats
#7
Patcharaporn Hengjumrut, Tosapol Anukunwithaya, Mayuree H Tantisira, Boonyong Tantisira, Phisit Khemawoot
1. ECa 233, the standardised extract of Centella asiatica, contains not less than 80% triterpenoid glycosides, in a madecassoside:asiaticoside ratio of 1.5 (± 0.5): 1. 2. The pharmacokinetic comparison of madecassoside and asiaticoside was performed in rats following intravenous and oral administration of ECa 233, or an equivalent dose of the individual compounds. Blood, tissues, urine and faeces were collected after dosing to determine drug and metabolite levels using liquid chromatography-tandem mass spectrometry...
December 21, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28000096/relationship-between-tissue-distributions-of-modified-wuzi-yanzong-prescription-in-rats-and-meridian-tropism-theory
#8
Lin-Lin Wang, Wei-Wei Li, Cai-Sheng Wu, Jin-Lan Zhang, Yi-Xiang Song, Fang-Jiao Song, Hong Fu, Geng-Xin Liu, Xue-Mei Wang
OBJECTIVE: To investigate the relationship between tissue distributions of modified Wuzi Yanzong prescription (, MWP) in rats and meridian tropism theory. METHODS: A high-performance liquid chromatography with Fourier transform-mass spectrometry (HPLC-FT) method was used to identify the metabolites of MWP in different tissues of rats after continued oral administration of MWP for 7 days. The relationship between MWP and meridian tropism theory was studied according to the tissue distributions of the metabolites of MWP in rats and the relevant literature...
December 20, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27999285/simultaneous-determination-of-multiple-components-in-guanjiekang-in-rat-plasma-via-the-uplc-ms-ms-method-and-its-application-in-pharmacokinetic-study
#9
Jian Wu, Ying Xie, Zheng Xiang, Canjian Wang, Hua Zhou, Liang Liu
Guanjiekang (GJK) that is formed by five medicinal herbs including Astragali Radix, Aconiti Lateralis Radix Praeparaia, Glycyrrhizae Radix et Rhizoma, Corydalis Rhizoma and Paeoniae Radix Alba was used for the treatment of rheumatoid arthritis (RA). However, the pharmacokinetic (PK) profile of active components in GJK remains unclear. This study aims to evaluate the pharmacokinetic behavior of seven representative active constituents in GJK (i.e., benzoylhypaconine, benzoylmesaconine, paeoniflorin, tetrahydropalmatine, calycosin-7-glucoside, formononetin and isoliquiritigenin) after oral administration of GJK in rats...
December 16, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27978495/brazilian-red-propolis-improves-cutaneous-wound-healing-suppressing-inflammation-associated-transcription-factor-nf%C3%AE%C2%BAb
#10
Flavia Regina Sobreira Corrêa, Fernanda Seabra Schanuel, Nathalia Moura-Nunes, Andréa Monte-Alto-Costa, Julio Beltrame Daleprane
The use of natural products in wound healing has been extensively studied in the context of complementary and alternative medicine. Propolis, a natural product, is a polyphenol-rich resin used for this purpose. This study aimed to investigate the effect of Brazilian Red Propolis Extract (BRPE) on inflammation and wound healing in mice, using a tissue repair model. The BRPE polyphenol content was analyzed by liquid chromatography coupled to mass spectrometry (LC/MS). A full-thickness excision lesion was created, and mice were treated orally with daily doses of vehicle solution (water-alcohol solution containing 2% of ethanol, control group) or 100mg/kg of BRPE (P100 group) during nine consecutive days...
December 12, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27932283/development-and-validation-of-a-liquid-chromatography-tandem-mass-spectrometry-assay-for-the-measurement-of-faecal-metronidazole
#11
Jinny Jeffery, Zoe J Vincent, Ruth M Ayling, Stephen J Lewis
BACKGROUND: Metronidazole is an oral antibiotic which is widely used in the treatment of patients with Clostridium difficile associated disease. METHODS: This article describes the validation of a LC-MS/MS assay for the measurement of metronidazole in human faecal samples. RESULTS: Matrix matched and aqueous standards showed no significant difference in performance for the routine calibration of the assay. D(4) deuterated metronidazole internal standard eluted with a different retention time to the undeuterated metronidazole on chromatography, hence zidovudine was used as an internal standard...
December 5, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27924594/adhesion-of-yeast-and-bacteria-to-oral-surfaces
#12
Richard D Cannon, Karl M Lyons, Kenneth Chong, Kathryn Newsham-West, Kyoko Niimi, Ann R Holmes
Colonization of surfaces in the human body by microorganisms is an early, essential, step in the initiation of infectious disease. We have developed in vitro assays to investigate interactions between yeast or bacterial cells and human tissues, fluids, or prostheses. Such assays can be used to identify the adhesins, ligands, and receptors involved in these interactions, for example, by determining which components of the microbe or human tissue/fluid interfere with adherence in the assay. The assays can also be applied to finding ways of preventing adhesion, and subsequent disease, by investigating the effects of different conditions and added compounds on adherence in the in vitro assays...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27916403/stability-of-synthetic-cathinones-in-oral-fluid-samples
#13
Briana Miller, Jiyoung Kim, Marta Concheiro
Synthetic cathinones are new stimulant drugs derived from cathinone that have been sold as "legal highs" worldwide. These compounds can elicit powerful effects such as delusions, hallucinations as well as other potentially dangerous behavior. New analogs with varying effects and potencies are constantly introduced in the market to evade legislation, and they are not detected by routine screening and confirmation methods. Oral fluid is an alternative matrix of increasing interest in forensic toxicology. Its collection is non-invasive and easily supervised, and positive drug findings typically reflect recent drug exposure...
December 1, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27907870/immunochromatographic-determination-of-bacopaside-i-in-biological-samples
#14
Sontaya Sookying, Dumrongsak Pekthong, Sarawut Oo-Puthinan, Watoo Phrompittayarat, Waraporn Putalun, Hiroyuki Tanaka, Jie Xing, Zhaoqi Zhan, Nantaka Khorana, Nitra Nuengchamnong, Kornkanok Ingkaninan
We describe a novel immunochromatographic method for qualitative and quantitative analyses of bacopaside I, a bioactive constituent in Bacopa monnieri (L.) Wettst in biological samples. The assay was performed on polyethersulfone membrane using a polyclonal antibody raised against bacopaside I. The finalised method could quantitatively determine bacopaside I in the range of 31.3-1000.0ng and the detection and quantification limits were 1.0 and 31.3ng, respectively. The percentage recoveries of bacopaside I in blood and urine were nearly 100% indicating the accuracy of the extraction...
January 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27907869/is-a-deuterated-internal-standard-appropriate-for-the-reliable-determination-of-olmesartan-in-human-plasma
#15
Edyta Piórkowska, Jacek Musijowski, Katarzyna Buś-Kwaśnik, Piotr J Rudzki
A right choice of the internal standard is one of the most challenging tasks during bioanalytical method development. Surprisingly, among the HPLC-MS methods for the determination of a cardiovascular drug olmesartan in plasma only structural analogues or similar compounds were used as internal standards. We have tried to answer the question whether the stable isotope labelled (deuterated) internal standard, as recommended by regulatory agencies, can be used for the reliable determination of olmesartan in human plasma...
January 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27896775/uplc-ms-ms-determination-of-deuterated-25-hydroxyvitamin-d-d3-25ohd3-and-other-vitamin-d-metabolites-for-the-measurement-of-25ohd-half-life
#16
Shima Assar, Inez Schoenmakers, Albert Koulman, Ann Prentice, Kerry S Jones
Plasma 25-hydroxyvitamin D (25OHD) half-life (25OHDt 1/2) is a dynamic marker of vitamin D metabolism that can be used to assess vitamin D expenditure and help inform vitamin D requirements. Our group recently established an approach to determine the 25OHDt 1/2 as an alternative biomarker of 25OHD expenditure in humans. The approach uses a small oral dose of stable isotope labeled 25OHD3 [3-(2)H-25OHD(3) (6,19,19-d3)] (d3-25OHD3) (tracer), which is distinguishable from endogenous 25OHD by liquid chromatography tandem-mass spectrometry (LC-MS/MS)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27877020/improved-oral-bioavailability-of-20-r-25-methoxyl-dammarane-3%C3%AE-12%C3%AE-20-triol-using-nanoemulsion-based-on-phospholipid-complex-design-characterization-and-in-vivo-pharmacokinetics-in-rats
#17
Xiangrong Zhang, Yi Zhang, Shuang Guo, Feifei Bai, Tong Wu, Yuqing Zhao
The aim of the study was to improve the oral absorption of the compound 25-OCH3-PPD with poor hydrophilicity and lipophilicity. 25-OCH3-PPD-phospholipid complex was prepared by solvent evaporation, then characterized by differential scanning calorimetry, scanning electron microscopy, and infrared absorption spectroscopy. The aqueous solubility and oil-water partition coefficient were compared with the free compound. A nanoemulsion loaded with 25-OCH3-PPD-phospholipid complex was developed by dissolving the complex in water in the presence of hydrophilic surfactant under sonication...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27874243/ultra-high-performance-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry-and-pharmacokinetic-analysis-of-justicidin-b-and-6-hydroxy-justicidin-c-in-rats
#18
Jiaoyang Luo, Yichen Hu, Jia'an Qin, Meihua Yang
Arylnaphthalene lignans have attracted considerable interest with the discovery of their antineoplastic activities. Two such compounds are justicidin B and 6'-hydroxy justicidin C, both of which have been isolated from the herb Justicia procumbens. We sought to develop and validate a sensitive and accurate, ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry method for the structural determination and pharmacokinetics of justicidin B and 6'-hydroxy justicidin C...
November 22, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27859436/tissue-distribution-of-capilliposide-b-capilliposide-c-and-their-bioactive-metabolite-in-mice-using-liquid-tandem-mass-spectrometry
#19
Zhongzhe Cheng, Xing Zhou, Bingying Hu, Wenyi Li, Guiying Chen, Yang Zhang, Jingkui Tian, Lin Zhang, Ming Li, Hongliang Jiang
Lysimachia capillipes Hemsl (Primulaceae), a folk medicinal plant in China, showed significant anti-tumor activities in vivo and in vitro. Capilliposide B (LC-B) and capilliposide C (LC-C) are the main bioactive components in this plant. To explore their tissue distribution, a reliable bioanalytical method for the quantification of LC-B, LC-C and their bioactive metabolite, capilliposide A (LC-A), in mouse tissues was developed and validated. In this study, the tissue distribution profiles of the three compounds were examined after intravenous administration of pure LC-B and oral administration of total saponins of L...
November 14, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27845609/bovine-teeth-as-a-novel-matrix-for-the-control-of-the-food-chain-liquid-chromatography-tandem-mass-spectrometry-detection-of-treatments-with-prednisolone-dexamethasone-estradiol-nandrolone-and-seven-%C3%AE-2-agonists
#20
Luca Maria Chiesa, Maria Nobile, Sara Panseri, Bartolomeo Biolatti, Francesca Tiziana Cannizzo, Radmila Pavlovic, Francesco Arioli
Veterinary drugs usually have rapid clearance rates in the liver and kidney, hampering their detection in conventional matrices such as the liver or urine. Pharmacological principles such as esterification may be applied to facilitate the administration of veterinary drugs and increase drug half-life. Prednisolone, whose therapeutic administration is regulated for food producing animals in the EU, is available in its acetate form as well as nandrolone, a banned anabolic steroid, which may be obtained as nandrolone phenylpropionate and estradiol as a benzoyl ester...
January 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
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