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Oral liquid compounding

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https://www.readbyqxmd.com/read/29757931/in-vitro-human-microbiota-response-to-exposure-to-silver-nanoparticles-biosynthesized-with-mushroom-extract
#1
Emanuel Vamanu, Mihaela Ene, Bogdan Biță, Cristina Ionescu, Liviu Crăciun, Ionela Sârbu
The ability to orally administer silver nanoparticles (AgNPs) in enteric capsules implies a direct interaction with the colon microbiota. The in vitro effect provides a portrayal of the functional properties under in vivo conditions. The purpose of this study was to describe a green AgNP synthesis process, using aqueous extract from Lactarius piperatus mushroom, and to characterize the nanomaterial. We determined its antimicrobial and antioxidant effects in vitro in the microbiota of healthy individuals via the GIS1 system-a colon transit simulator...
May 14, 2018: Nutrients
https://www.readbyqxmd.com/read/29753212/quantification-of-doping-compounds-in-faecal-samples-from-racing-pigeons-by-liquid-chromatography-tandem-mass-spectrometry
#2
Fernando X Moreira, Renata Silva, Maria B André, Paula G de Pinho, Maria L Bastos, João Ruivo, Patrícia Ruivo, Helena Carmo
The use of performance enhancing drugs is not only common in humans, but also in animal sports, including racing of horses, greyhounds and pigeons. The development of accurate analytical procedures to detect doping agents in sports is crucial in order to protect the fair-play of the game, avoid financial fraud in the attribution of eventual awards and, even more important, to protect the animals from harmful drugs and/or dangerous dosage regimens. The present study aimed to develop and validate, a method that enabled the screening and confirmation of the presence of a beta-agonist (clenbuterol) and three corticosteroids (betamethasone, prednisolone and budesonide) in faeces from pigeons...
May 4, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29751639/novel-neuroprotective-lead-compound-ligustrazine-derivative-mass-spectrometry-fragmentation-rule-and-metabolites-in-rats-by-lc-ltq-orbitrap-ms
#3
Xinyu Zhang, Rui Zhao, Meng Chen, Tao Ma, Gaorong Wu, Nannan Xue, Guoliang Li, Hui Wang, Kang Fang, Wenxi Zhang, Penglong Wang, Haimin Lei
The neuroprotective evaluation of ligustrazine derivatives has become a research focus all over the world. A novel ligustrazine derivative, (3,5,6-Trimethylpyrazin-2-yl)methyl(E)-3-(4-((3,5,6-trimethylpyrazin-2-l)methoxy)phenyl)acrylate (T-CA), has shown protective effects against CoCl₂-induced neurotoxicity in a differentiated PC12 cell model and middle cerebral artery occlusion (MCAO) model in our previous studies. However, nearly none of the parent drugs existed after rapid metabolism due to uncertain reasons...
May 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29720840/rapid-screening-and-characterization-of-acetylcholinesterase-inhibitors-from-yinhuang-oral-liquid-using-ultrafiltration-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry
#4
Haomin Zhang, Yinan Guo, Lingwen Meng, Hui Sun, Yinping Yang, Ying Gao, Jiaming Sun
Background: At present, approximately 17-25 million people in the world suffer from Alzheimer's disease (AD). The most efficacious and acceptable therapeutic drug clinically are the acetylcholinesterase inhibitors (AChEIs). Yinhuang oral liquid is a Chinese medicine preparation which contains AChEIs according to the literatures. However, no strategy has been presented for rapid screening and identification of AChEIs from Yinhuang oral liquid. Objective: To develop a method for rapid screening and identification of AChEIs from Yinhuang oral liquid using ultrafiltration-liquid chromatography-electrospray ionization tandem mass spectrometry (UF-LC-ESI-MS/MS)...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29695040/gastroprotective-and-antioxidant-activity-of-kalanchoe-brasiliensis-and-kalanchoe-pinnata-leaf-juices-against-indomethacin-and-ethanol-induced-gastric-lesions-in-rats
#5
Edilane Rodrigues Dantas de Araújo, Gerlane Coelho Bernardo Guerra, Daline Fernandes de Souza Araújo, Aurigena Antunes de Araújo, Júlia Morais Fernandes, Raimundo Fernandes de Araújo Júnior, Valéria Costa da Silva, Thaís Gomes de Carvalho, Leandro de Santis Ferreira, Silvana Maria Zucolotto
Kalanchoe brasiliensis and Kalanchoe pinnata are used interchangeably in traditional medicine for treating peptic ulcers and inflammatory problems. In this context, this study aims to characterize the chemical constituents and evaluate the gastroprotective activity of the leaf juices of the two species in acute gastric lesions models. Thin Layer Chromatography (TLC) and Ultra High Performance Liquid Chromatography coupled to Mass Spectrometer (UHPLC-MS) were performed for chemical characterization. Wistar rats were pre-treated orally with leaf juices (125, 250 and 500 mg/kg) or ranitidine (50 mg/kg)...
April 24, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29691267/stability-of-extemporaneously-prepared-cinacalcet-oral-suspensions
#6
Kara Thomson, David J Hutchinson, Lipika Chablani
PURPOSE: The stability of extemporaneously prepared cinacalcet suspensions over 90 days was evaluated. METHODS: Cinacalcet 5-mg/mL suspension was prepared by triturating 30-mg cinacalcet tablets. Twelve 30-mL batches were prepared with a 1:1 mixture of Ora-Plus and either Ora-Sweet or Ora-Sweet SF (sugar free). Three suspensions of each kind were stored at both room temperature and refrigerated conditions. A 1-mL sample was taken from each bottle at 0, 7, 18, 32, 64, and 90 days...
May 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29677683/application-of-solid-phase-microextraction-followed-by-liquid-chromatography-mass-spectrometry-in-the-determination-of-antibiotic-drugs-and-their-metabolites-in-human-whole-blood-and-tissue-samples
#7
Malgorzata Szultka-Mlynska, Pawel Pomastowski, Boguslaw Buszewski
A sensitive, rapid and specific analytical method using high performance liquid chromatography coupled with mass spectrometry (HPLC-QqQ-MS) was developed to determine selected antibiotic drugs and their metabolites (amoxicillin, cefotaxime, ciprofloxacin, clindamycin and metronidazole; amoxycilloic acid, 4-hydroxyphenyl glycyl amoxicillin, desacetyl cefotaxime, 3-desacetyl cefotaxime lactone, ciprofloxacin N-oxide, N-demethylclindamycin, clindamycin sulfoxide, and hydroxy metronidazole) in human whole blood and vascularized tissue after single oral administration...
April 12, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29673871/tailored-on-demand-anti-coagulant-dosing-an-in-vitro-and-in-vivo-evaluation-of-3d-printed-purpose-designed-oral-dosage-forms
#8
Basel Arafat, Nidal Qinna, Milena Cieszynska, Robert T Forbes, Mohamed A Alhnan
Coumarin therapy has been associated with high levels of inter- and intra-individual variation in the required dose to reach a therapeutic anticoagulation outcome. Therefore, a dynamic system that is able to achieve accurate delivery of a warfarin dose is of significant importance. Here we assess, the ability of 3D printing to fabricate and deliver tailored individualised precision dosing using an in-vitro model. Sodium warfarin loaded filaments were compounded using hot melt extrusion (HME) and further fabricated via fused deposition modelling (FDM) 3D printing to produce capsular-ovoid-shaped dosage forms loaded at 200 and 400 µg dose...
April 16, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29662844/mineral-elements-bio-accessibility-and-antioxidant-indices-of-blanched-basella-rubra-at-different-phases-of-in-vitro-gastrointestinal-digestion
#9
Sule Ola Salawu, Bukola Eugenia Olukemi, Ikuosho Charity Asikhia, Akintunde Afolabi Akindahunsi
The present investigation was designed to evaluate the mineral element bio-accessibility and antioxidant indices of blanched Basella rubra at different phases of simulated in vitro digestion (oral, gastric, and intestinal). The phenolic composition of processed vegetable was determined using high-performance liquid chromatography (HPLC)-diode-array detection method. Mineral composition, total phenolic content (TPC), total flavonoid content (TFC), ferric reducing antioxidant power (FRAP), and total antioxidant activity (TAA) of the in vitro digested blanched and raw vegetable were also determined...
March 2018: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29609685/stability-of-regularly-prescribed-oral-liquids-formulated-with-syrspend-%C3%A2-sf
#10
M Uriel, C Gómez-Rincón, D Marro
The purpose of this research was to evaluate the stability of 12 oral liquid formulations frequently compounded in hospital and community settings formulated in a specific vehicle: SyrSpend® SF. The stability of melatonin, glycopyrrolate, ciclosporin, chloral hydrate, flecainide acetate, tiagabine HCl, labetalol HCl, ciprofloxacin HCl, spironolactone/hydrochlorothiazide, hydrocortisone, itraconazole and celecoxib in SyrSpend SF PH4 (liquid) was investigated at 0, 30, 60 and 90 days and stored at both controlled room temperature and refrigerated...
April 2, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29597038/simultaneous-determination-of-eight-bioactive-compounds-by-lc-ms-ms-and-its-application-to-the-pharmacokinetics-liver-first-pass-effect-liver-and-brain-distribution-of-orally-administrated-gouteng-baitouweng-gb-in-rats
#11
Xiaoting Tian, Zhou Xu, Mingcang Chen, Pei Hu, Fang Liu, Zhaolin Sun, Huan Liu, Xiaozheng Guo, Zhixiong Li, Chenggang Huang
Only focusing on the circulating levels is insufficient for the comprehensive understanding of the physiological disposition of herbal medicine in vivo. Therefore, we conducted the comprehensive investigation on the in vivo dynamic process of orally administrated Gouteng-Baitouweng (GB), a classical herb pair with anti-Parkinson potentials. Serving as the technical base, a sensitive and selective liquid chromatography-tandem mass spectrometry method was established and validated in the plasma, liver and brain, for simultaneous determination of five alkaloids (rhynchophylline, isorhynchophylline, corynoxeine, isocorynoxeine and geissoschizine methyl ether) and three saponins (anemoside B4, anemoside A3 and 23-hydroxybetulinic acid)...
March 9, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29575649/detection-and-pharmacokinetics-of-grapiprant-following-oral-administration-to-exercised-thoroughbred-horses
#12
Heather K Knych, Kelsey Seminoff, Dan S McKemie
Traditional therapeutic options for the treatment of lameness associated with inflammation in performance horses include administration of cyclooxygenase enzyme inhibiting non-steroidal anti-inflammatory drugs (NSAID). As long-term use of these drugs can adversely impact the health of the horse, anti-inflammatories with a more favorable safety profile are warranted. Grapiprant is a newly approved non-cyclooxygenase inhibiting NSAID that has demonstrated efficacy and safety in other species and which may be a valuable alternative to traditional NSAIDs used in the horse...
March 25, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29573149/freeze-thaw-approach-a-practical-sample-preparation-strategy-for-residue-analysis-of-multi-class-veterinary-drugs-in-chicken-muscle
#13
Meiyu Zhang, Erfen Li, Yijuan Su, Xuqin Song, Jingmeng Xie, Yingxia Zhang, Limin He
Seven drugs from different classes, namely, fluoroquinolones (enrofloxacin, ciprofloxacin, sarafloxacin), sulfonamides (sulfadimidine, sulfamonomethoxine) and macrolides (tilmicosin, tylosin), were used as test compounds in chickens by oral administration, a simple extraction step after cryogenic freezing might allow the effective extraction of multi-class veterinary drug residues from minced chicken muscles by mix vortexing. On basis of the optimized freeze-thaw approach, a convenient, selective and reproducible liquid chromatography with tandem mass spectrometry method was developed...
March 23, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29567258/a-new-strategy-for-choosing-q-markers-via-network-pharmacology-application-to-the-quality-control-of-a-chinese-medical-preparation
#14
Wei Xiang, Tong-Chuan Suo, Hua Yu, An-Ping Li, Shou-Qing Zhang, Chun-Hua Wang, Yan Zhu, Zheng Li
Due to its chemical complexity, proper quality control for a Chinese medical preparation (CMP) has been a great challenge. Choosing the appropriate quality markers (Q-markers) for quality control of CMP is an important work. Best of all, the chosen Q-markers are the main chemical compounds from the herbals as well as the active constituents of this CMP. Only in this way the established quality control system can really achieve the purpose of controlling the quality of CMP and ensuring the safely and effectively use of CMP...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29556193/pharmacokinetic-study-of-7-compounds-following-oral-administration-of-fructus-aurantii-to-depressive-rats
#15
Xianhua Zhang, Linran Han, Jin Liu, Qiuyue Xu, Yuxin Guo, Wan Zheng, Jian Wang, Xi Huang, Ping Ren
In the present study, the pharmacokinetics of multi-components (naringenin, nobiletin, meranzin hydrate, narirutin, naringin, hesperidin, and neohesperidin) were investigated in acute depressive rats following oral administration of Fructus Aurantii (Zhi-Qiao, ZQ) extract (20 g/kg). A rapid and reliable liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was established to quantitatively or qualitatively analyze the 7 absorbed ingredients in the plasma, hippocampus and cortex of acute depressive rats...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29534330/the-oral-bioavailability-of-trans-resveratrol-from-a-grapevine-shoot-extract-in-healthy-humans-is-significantly-increased-by-micellar-solubilization
#16
Laura A Calvo-Castro, Christina Schiborr, Franziska David, Heidi Ehrt, Jenny Voggel, Nadine Sus, Dariush Behnam, Anja Bosy-Westphal, Jan Frank
SCOPE: Grapevine-shoot extract Vineatrol® 30 contains abundant resveratrol monomers and oligomers with health-promoting potential. However, the oral bioavailability of these compounds in humans is low (˂1-2%). The aim of this study was to improve the oral bioavailability of resveratrol from vineatrol by micellar solubilization. METHODS AND RESULTS: Twelve healthy volunteers (6 women, 6 men) randomly ingested a single dose of 500 mg vineatrol (30 mg trans-resveratrol, 75 mg trans-ε-viniferin) as native powder or liquid micelles...
March 13, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29520993/ultraviolet-visible-phototransformation-of-dehydroacetic-acid-structural-characterization-of-photoproducts-and-global-ecotoxicity
#17
Ségolène De Vaugelade, Edith Nicol, Svetlana Vujovic, Sophie Bourcier, Stéphane Pirnay, Stéphane Bouchonnet
RATIONALE: The present work is devoted to the structural elucidation of by-products issued from the direct ultraviolet-visible (UV-vis) irradiation of dehydroacetic acid (DHA) in solution and in cosmetic emulsion. METHODS: Analyses were carried out using gas chromatography coupled with ion trap mass spectrometry and by high-performance liquid chromatography coupled with ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry (LC/UHRMS). The potential toxicities of by-products were estimated by in silico calculations based on a QSAR (Quantitative Structure-Activity Relationship) approach and by in vitro bioassays conducted on Vibrio fischeri bacteria...
June 15, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29518720/lc-ms-ms-method-for-the-simultaneous-quantification-of-luteolin-wedelolactone-and-apigenin-in-mice-plasma-using-hansen-solubility-parameters-for-liquid-liquid-extraction-application-to-pharmacokinetics-of-eclipta-alba-chloroform-fraction
#18
Hanumanth Srikanth Cheruvu, Navneet K Yadav, Guru R Valicherla, Rakesh K Arya, Zakir Hussain, Chetan Sharma, Kamal R Arya, Rama K Singh, Dipak Datta, Jiaur R Gayen
Eclipta alba (Bhringraj) in ayurveda has been widely used as a traditional medicine for its multi-therapeutic properties for ages. Luteolin (LTL), wedelolactone (WDL) and apigenin (APG) are the three main bioactive phytochemicals present in Eclipta alba extract. However there was a lack of sensitive bioanalytical method for the pharmacokinetics of these free compounds in plasma which majorly contributes for their activities after oral administration of Eclipta alba. The present study aims to develop a sensitive, rapid and reliable liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the simultaneous estimation of mice plasma concentrations of LTL, WDL and APG using quercetin as an internal standard for the pharmacokinetic analysis...
April 1, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29518030/absolute-oral-bioavailability-of-creatine-monohydrate-in-rats-debunking-a-myth
#19
Eman A Alraddadi, Ryan Lillico, Jonathan L Vennerstrom, Ted M Lakowski, Donald W Miller
Creatine is an ergogenic compound used by athletes to enhance performance. Supplementation with creatine monohydrate (CM) has been suggested for musculoskeletal and neurological disorders. Until now, little is known about its pharmacokinetic profile. Our objective was to determine the oral bioavailability of CM and the influence of dose on oral absorption. Rats were dosed orally with low dose (10 mg/kg) or high dose (70 mg/kg) 13 C-labeled CM. Blood samples were removed at various time points. Muscle and brain tissue were collected at the conclusion of the study...
March 8, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29501772/antihyperlipidemic-effect-of-a-rhamnus-alaternus-leaf-extract-in-triton-induced-hyperlipidemic-rats-and-human-hepg2-cells
#20
Mustapha Tacherfiout, Petar D Petrov, Marco Mattonai, Erika Ribechini, Joan Ribot, M Luisa Bonet, Bachra Khettal
The Mediterranean buckthorn, Rhamnus alaternus L., is a plant used in traditional medicine in Mediterranean countries. We aimed at characterizing its phenolic compounds and explore potential antihyperlipidemic activity of this plant. The profile of phenolic compounds in R. alaternus leaf crude methanolic extract (CME) and its liquid-liquid extraction-derived fractions were analyzed by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC/ESI-MS2 ). Effects of CME on: circulating lipids in rats with Triton WR-1339-induced hyperlipidemia, intracellular lipid accumulation and expression of genes of fatty acid metabolism in human hepatoma HepG2 cells, and adipogenesis in the 3T3-L1 murine adipocyte cell model were assessed...
May 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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