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https://www.readbyqxmd.com/read/27916403/stability-of-synthetic-cathinones-in-oral-fluid-samples
#1
Briana Miller, Jiyoung Kim, Marta Concheiro
Synthetic cathinones are new stimulant drugs derived from cathinone that have been sold as "legal highs" worldwide. These compounds can elicit powerful effects such as delusions, hallucinations as well as other potentially dangerous behavior. New analogs with varying effects and potencies are constantly introduced in the market to evade legislation, and they are not detected by routine screening and confirmation methods. Oral fluid is an alternative matrix of increasing interest in forensic toxicology. Its collection is non-invasive and easily supervised, and positive drug findings typically reflect recent drug exposure...
December 1, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27907870/immunochromatographic-determination-of-bacopaside-i-in-biological-samples
#2
Sontaya Sookying, Dumrongsak Pekthong, Sarawut Oo-Puthinan, Watoo Phrompittayarat, Waraporn Putalun, Hiroyuki Tanaka, Jie Xing, Zhaoqi Zhan, Nantaka Khorana, Nitra Nuengchamnong, Kornkanok Ingkaninan
We describe a novel immunochromatographic method for qualitative and quantitative analyses of bacopaside I, a bioactive constituent in Bacopa monnieri (L.) Wettst in biological samples. The assay was performed on polyethersulfone membrane using a polyclonal antibody raised against bacopaside I. The finalised method could quantitatively determine bacopaside I in the range of 31.3-1000.0ng and the detection and quantification limits were 1.0 and 31.3ng, respectively. The percentage recoveries of bacopaside I in blood and urine were nearly 100% indicating the accuracy of the extraction...
November 23, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27907869/is-a-deuterated-internal-standard-appropriate-for-the-reliable-determination-of-olmesartan-in-human-plasma
#3
Edyta Piórkowska, Jacek Musijowski, Katarzyna Buś-Kwaśnik, Piotr J Rudzki
A right choice of the internal standard is one of the most challenging tasks during bioanalytical method development. Surprisingly, among the HPLC-MS methods for the determination of a cardiovascular drug olmesartan in plasma only structural analogues or similar compounds were used as internal standards. We have tried to answer the question whether the stable isotope labelled (deuterated) internal standard, as recommended by regulatory agencies, can be used for the reliable determination of olmesartan in human plasma...
November 16, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27896775/uplc-ms-ms-determination-of-deuterated-25-hydroxyvitamin-d-d3-25ohd3-and-other-vitamin-d-metabolites-for-the-measurement-of-25ohd-half-life
#4
Shima Assar, Inez Schoenmakers, Albert Koulman, Ann Prentice, Kerry S Jones
Plasma 25-hydroxyvitamin D (25OHD) half-life (25OHDt 1/2) is a dynamic marker of vitamin D metabolism that can be used to assess vitamin D expenditure and help inform vitamin D requirements. Our group recently established an approach to determine the 25OHDt 1/2 as an alternative biomarker of 25OHD expenditure in humans. The approach uses a small oral dose of stable isotope labeled 25OHD3 [3-(2)H-25OHD(3) (6,19,19-d3)] (d3-25OHD3) (tracer), which is distinguishable from endogenous 25OHD by liquid chromatography tandem-mass spectrometry (LC-MS/MS)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27877020/improved-oral-bioavailability-of-20-r-25-methoxyl-dammarane-3%C3%AE-12%C3%AE-20-triol-using-nanoemulsion-based-on-phospholipid-complex-design-characterization-and-in-vivo-pharmacokinetics-in-rats
#5
Xiangrong Zhang, Yi Zhang, Shuang Guo, Feifei Bai, Tong Wu, Yuqing Zhao
The aim of the study was to improve the oral absorption of the compound 25-OCH3-PPD with poor hydrophilicity and lipophilicity. 25-OCH3-PPD-phospholipid complex was prepared by solvent evaporation, then characterized by differential scanning calorimetry, scanning electron microscopy, and infrared absorption spectroscopy. The aqueous solubility and oil-water partition coefficient were compared with the free compound. A nanoemulsion loaded with 25-OCH3-PPD-phospholipid complex was developed by dissolving the complex in water in the presence of hydrophilic surfactant under sonication...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27874243/uhplc-esi-ms-ms-and-pharmacokinetic-analysis-of-justicidin-b-and-6-hydroxy-justicidin-c-in-rats
#6
Jiaoyang Luo, Yichen Hu, Jia'an Qin, Meihua Yang
Arylnaphthalene lignans have attracted considerable interest with the discovery of their antineoplastic activities. Two such compounds are justicidin B and 6'-hydroxy justicidin C, both of which have been isolated from the herb Justicia procumbens. We sought to develop and validate a sensitive and accurate, ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry method for the structural determination and pharmacokinetics of justicidin B and 6'-hydroxy justicidin C...
November 22, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27859436/tissue-distribution-of-capilliposide-b-capilliposide-c-and-their-bioactive-metabolite-in-mice-using-liquid-chromatography-tandem-mass-spectrometry
#7
Zhongzhe Cheng, Xing Zhou, Bingying Hu, Wenyi Li, Guiying Chen, Yang Zhang, Jingkui Tian, Lin Zhang, Ming Li, Hongliang Jiang
Lysimachia capillipes Hemsl (Primulaceae), a folk medicinal plant in China, showed significant anti-tumor activities in vivo and vitro. Capilliposide B (LC-B) and Capilliposide C (LC-C) were the main bioactive components in this plant. To explore their tissue distribution, a reliable bioanalytical method for the quantification of LC-B, LC-C, and their bioactive metabolite, Capilliposide A (LC-A) in mice tissues was developed and validated. In this study, the tissue distribution profiles of the three compounds were examined after intravenous administration of pure LC-B and oral administration of total saponins of L...
November 14, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27845609/bovine-teeth-as-a-novel-matrix-for-the-control-of-the-food-chain-liquid-chromatography-tandem-mass-spectrometry-detection-of-treatments-with-prednisolone-dexamethasone-estradiol-nandrolone-and-seven-%C3%AE-2-agonists
#8
Luca Maria Chiesa, Maria Nobile, Sara Panseri, Bartolomeo Biolatti, Francesca Tiziana Cannizzo, Radmila Pavlovic, Francesco Arioli
Veterinary drugs usually have rapid clearance rates in the liver and kidney, hampering their detection in conventional matrices such as the liver or urine. Pharmacological principles such as esterification may be applied to facilitate the administration of veterinary drugs and increase drug half-life. Prednisolone, whose therapeutic administration is regulated for food producing animals in the EU, is available in its acetate form as well as nandrolone, a banned anabolic steroid, which may be obtained as nandrolone phenylpropionate and estradiol as a benzoyl ester...
November 15, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27825899/influence-of-culture-conditions-on-porphyrin-production-in-aggregatibacter-actinomycetemcomitans-and-porphyromonas-gingivalis
#9
Jonas Fyrestam, Nadja Bjurshammar, Elin Paulsson, Nesrine Mansouri, Annsofi Johannsen, Conny Östman
BACKGROUND: Increasing antibiotic resistance among pathogens has raised the demands for new treatment methods such as antimicrobial photodynamic therapy (aPDT) and phototherapy (PT). Experiments for investigating the effects of these methods are often performed in vitro, but the procedures for cultivation of microbes vary between different studies. The aim of this study has been to elucidate how the profile of endogenously produced porphyrins differs by changing the variables of bacteria culturing conditions...
November 4, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27812583/the-modulatory-effect-of-infusions-of-green-tea-oolong-tea-and-black-tea-on-gut-microbiota-in-high-fat-induced-obese-mice
#10
Zhibin Liu, Zhichao Chen, Hongwen Guo, Dongping He, Huiru Zhao, Zhiyao Wang, Wen Zhang, Lan Liao, Chen Zhang, Li Ni
Tea consumption has been identified to have an anti-obesity effect. Whether it is associated with gut microbiota modulation is investigated in this study. Phenolic profiles of infusions of green tea, oolong tea and black tea were comprehensively compared first, by utilizing ultra-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry (UPLC-ESI-Q-TOFMS). Subsequently, high-fat-diet induced obese C57BL/6J mice were orally administered these three types of tea infusions for 13 weeks to evaluate their anti-obesity and gut microbiota modulatory effects...
November 4, 2016: Food & Function
https://www.readbyqxmd.com/read/27805254/effect-of-a-novel-oral-chemotherapeutic-agent-containing-a-combination-of-trifluridine-tipiracil-and-the-novel-triple-angiokinase-inhibitor-nintedanib-on-human-colorectal-cancer-xenografts
#11
Norihiko Suzuki, Fumio Nakagawa, Kazuaki Matsuoka, Teiji Takechi
Trifluridine/tipiracil (TFTD) is a combination drug that is used for the treatment of metastatic colorectal cancer and was formerly known as TAS-102. It is a combination of two active pharmaceutical compounds, trifluridine, an antineoplastic thymidine-based nucleoside analog, and tipiracil, which enhances the bioavailability of trifluridine in vivo. TFTD is used for the treatment of patients with unresectable advanced or recurrent colorectal cancer that is resistant to standard therapies. In the present study, the anticancer effects of trifluridine in combination with nintedanib, an oral triple angiokinase inhibitor, on human colorectal cancer cell lines were investigated...
December 2016: Oncology Reports
https://www.readbyqxmd.com/read/27793918/cytotoxic-components-against-human-oral-squamous-cell-carcinoma-isolated-from-andrographis-paniculata
#12
Ryuichiro Suzuki, Yasuaki Matsushima, Noriyuki Okudaira, Hiroshi Sakagami, Yoshiaki Shirataki
BACKGROUND: The 5-year survival rate of patients with oral cancer has remained approximately 50% during the past 30 years, possibly due to the poor tumor selectivity of conventional anticancer drugs. This prompted us to search for new candidates for anticancer drugs that have higher cytotoxicity and tumor selectivity. MATERIALS AND METHODS: Dried leaves of Andrographis paniculata were supplied from a market in Shanghai. The methanolic fraction of A. paniculata was further fractionated to identify cytotoxic principles by spectroscopic analysis and comparison with literature values...
November 2016: Anticancer Research
https://www.readbyqxmd.com/read/27781278/improving-the-oral-bioavailability-of-buprenorphine-an-in-vivo-proof-of-concept
#13
Anand Joshi, Matthew Halquist, Zacharoula Konsoula, Yongzhen Liu, J P Jones, Christian Heidbreder, Phillip M Gerk
OBJECTIVES: The aim of this study was to improve the oral bioavailability of buprenorphine by inhibiting presystemic metabolism via the oral co-administration of 'Generally Recognized as Safe' compounds, thus providing an orally administered drug product with less variability and comparable or higher exposure compared with the sublingual route. METHODS: The present studies were performed in Sprague Dawley rats following either intravenous or oral administration of buprenorphine/naloxone and oral co-administration of 'Generally Recognized as Safe' compounds referred to as 'adjuvants'...
October 26, 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27778479/rapid-discovery-of-absorbed-constituents-and-metabolites-in-rat-plasma-after-the-oral-administration-of-zi-shen-wan-using-high-throughput-uhplc-ms-with-a-multivariate-analysis-approach
#14
Xian-Na Li, Aihua Zhang, Hui Sun, Yanhua Song, Di Zou, Xijun Wang
Zi Shen Wan is a typical formula consisting of three herbs, Phellodendri Amurensis Cortex, Rhizoma Anemarrhenae, and Cortex Cinnamomi, and has been widely used for treating prostatitis and infection diseases. However, it lacks in-depth research of the constituents of Zi Shen Wan in vivo and in vitro. In this work, ultra high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry and MassLynx software was established to characterize the chemical compositions of Zi Shen Wan in vivo and in vitro...
October 24, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27774911/self-emulsifying-pellets-prepared-by-extrusion-spheronization-in-vitro-in-vivo-evaluation
#15
Md Akhlaquer Rahman, Md Mujahid, Arshad Hussain
AIMS: The purpose of the current study was to investigate the feasibility of producing solid self-emulsifying pellets using the extrusion/spheronization technique with an aim to increase the bioavailability of selected drug and also to encounter the problems associated with liquid lipid formulations. Self-emulsifying formulations are experiencing a very active development as reflected by the numerous publications and patents being granted on these systems. The patents on self-emulsifying formulation (US20036630150) and (US20006054136) helped in selecting the drug and excipients...
October 21, 2016: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/27751828/assessment-of-anti-diabetic-activity-of-the-aqueous-extract-of-leaves-of-astilboides-tabularis
#16
Zhihui Liu, Jianxiu Zhai, Na Han, Jun Yin
ETHNOPHARMACOLOGICAL RELEVANCE: Astilboides tabularis has a long history of usage as the functional food with the effect of adjunctive therapy of diabetic in northeast of China. The present study was undertaken to assess anti-diabetic activity of the aqueous extract of leaves of A. tabularis and provided experimental evidence for the clinical usage of A. tabularis in the treatment of diabetes mellitus. MATERIALS AND METHODS: The aqueous extracts of leaves of A. tabularis (EAT) were orally administered at 300 and 600mg/kg dose to epinephrine-induced and alloxan-induced diabetes mice...
October 14, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27747224/effect-of-oral-coadministration-of-ascorbic-acid-with-ling-zhi-preparation-on-pharmacokinetics-of-ganoderic-acid-a-in-healthy-male-subjects-a-randomized-crossover-study
#17
Patcharanee Tawasri, Chadarat Ampasavate, Somsak Tharatha, Natthakarn Chiranthanut, Supanimit Teekachunhatean
The objective of this randomized, open-label, single-dose, two-phase crossover study was to determine the effect of ascorbic acid on pharmacokinetics of ganoderic acid A, an important biologically active triterpenoid compound with anticancer activities, following oral administration of water extract of fruiting bodies of Ling Zhi in 12 healthy male subjects. Each subject was randomized to receive either one of the two regimens: (1) a single dose of 3,000 mg of the Ling Zhi preparation or (2) a single dose of 3,000 mg of the Ling Zhi preparation in combination with 2,500 mg of ascorbic acid...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27732901/uvaria-rufa-blume-attenuates-benign-prostatic-hyperplasia-via-inhibiting-5%C3%AE-reductase-and-enhancing-antioxidant-status
#18
Wararut Buncharoen, Kanokporn Saenphet, Supap Saenphet, Chatchote Titaram
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional medicine has used Uvaria rufa Blume as an ethnomedicinal plant for treating fever, skin allergies, intestinal ulcers and prostate disorders including BPH. However, no scientific evidence supports the traditional use. AIM OF THE STUDY: This study aimed to evaluate the therapeutic potential of U. rufa on BPH using in vitro and in vivo models. MATERIALS AND METHODS: In vitro studies screened the efficacy of a 5α-reductase (5αR) inhibition and antioxidant activity of petroleum ether, ethyl acetate, ethanol and aqueous extracts from the stem of U...
October 9, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27729163/higher-dermal-exposure-of-cashiers-to-bpa-and-its-association-with-dna-oxidative-damage
#19
Yanshan Lv, Shaoyou Lu, Yanyan Dai, Caiyan Rui, Yongjun Wang, Yuanxiu Zhou, Yanru Li, Qihua Pang, Ruifang Fan
Bisphenol A (BPA) is a widely used chemical in the production of many polycarbonate plastics, epoxy resin linings for food and beverage containers and thermal papers. Oral intakes from the contaminated diets were considered as the predominant source of BPA exposure for humans. However, due to the high levels of BPA on thermal receipts and their wide applications in our daily life, the amount of BPA be transferred to the skin after holding thermal paper should not be underestimated, particularly for cashiers...
October 8, 2016: Environment International
https://www.readbyqxmd.com/read/27727306/stability-of-diazoxide-in-extemporaneously-compounded-oral-suspensions
#20
Mihaela Friciu, Sarra Zaraa, V Gaëlle Roullin, Grégoire Leclair
The objective of this study was to evaluate the stability of diazoxide in extemporaneously compounded oral suspensions. Oral suspensions of diazoxide 10 mg/mL were prepared from either bulk drug or capsules dispersed in either Oral Mix or Oral Mix Sugar Free. These suspensions were stored at 5°C and 25°C/60%RH in bottles and oral syringes for a total of 90 days. At predetermined time intervals, suspensions were inspected for homogeneity, color or odor change; the pH was measured and the concentration of diazoxide was evaluated by ultraviolet detection using a stability-indicating high pressure liquid chromatography method...
2016: PloS One
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