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Oral liquid compounding

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https://www.readbyqxmd.com/read/28346214/suspensions-as-a-valuable-alternative-to-extemporaneously-compounded-capsules
#1
Eli Dijkers, Valerie Nanhekhan, Astrid Thorissen, Hudson Polonini
The objective of this study was to determine the variation in content of 74 different active pharmaceutical ingredients (APIs) and compare it with what is known in the literature for the content uniformity of extemporaneous prepared capsules. Active pharmaceutical ingredients quantification was performed by high-performance liquid chromatography, via a stability-indicating method. Samples for all active pharmaceutical ingredients were taken throughout a 90-day period and the content was determined. In total, 5,190 different samples were analyzed for 74 different active pharmaceutical ingredients at room (15°C to 25°C) or controlled refrigerated temperature (2°C to 8°C)...
March 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28346212/stability-of-extemporaneously-prepared-hydroxycarbamide-oral-suspensions
#2
Djamila Kabiche, Issa-Bella Balde, Elyes Majoul, Sofiane Kabiche, Elodie Bourguignon, Jean-Eudes Fontan, Salvatore Cisternino, Jöel Schlatter
Hydroxycarbamide, available as tablets, is a pharmacological agent for fetal hemoglobin induction such as sickle cell anemia. The need for alternative dosage form options for patients unable to take tablets led hospital pharmacies to prepare solutions and suspensions. The objective of this study was to determine the stability of hydroxycarbamide in Ora-Plus in combination with either Ora-Sweet or Ora-Sweet SF, Ora-Blend, or Ora-Blend SF suspending agents. The studied samples were compounded into 100-mg/mL suspensions and stored in 60-mL amber glass bottles at room (22°C to 25°C) or refrigerated (4°C to 8°C) temperature...
March 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28346002/quality-assessment-of-fluconazole-capsules-and-oral-suspensions-compounded-by-pharmacies-located-in-the-united-states
#3
Carine M Laporte, Crisanta Cruz-Espindola, Kamoltip Thungrat, Anthea E Schick, Thomas P Lewis, Dawn M Boothe
OBJECTIVE To evaluate pharmaceutical characteristics (strength or concentration, accuracy, and precision), physical properties, and bacterial contamination of fluconazole compounded products. SAMPLE Fluconazole compounded products (30- and 240-mg capsules; 30- and 100-mg/mL oral suspensions) from 4 US veterinary compounding pharmacies. PROCEDURES Fluconazole compounded products were ordered 3 times from each of 4 pharmacies at 7- or 10-day intervals. Generic fluconazole products (50- and 200-mg tablets; 10- and 40-mg/mL oral suspensions) served as references...
April 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28339378/stability-of-allopurinol-amitriptyline-hydrochloride-carbamazepine-domperidone-isoniazid-ketoconazole-lisinopril-naproxen-paracetamol-acetaminophen-and-sertraline-hydrochloride-in-syrspend-sf-ph4-oral-suspensions
#4
Hudson C Polonini, Sharlene Loures, Edson Peter de Araujo, Marcos Antônio F Brandão, Anderson O Ferreira
Oral liquids are safe alternatives to solid dosage forms, notably for elderly and pediatric patients that present dysphagia. The use of ready-to-use suspending vehicles such as SyrSpend SF PH4 is a suitable resource for pharmacists as they constitute a safe and timesaving option that has been studied often. The objective of this study was to evaluate the stability of 10 commonly used active pharmaceutical ingredients (allopurinol 20 mg/mL; amitriptyline hydrochloride 10 mg/mL; carbamazepine 25 mg/mL; domperidone 5 mg/mL; isoniazid 10 mg/mL; ketoconazole 20 mg/mL; lisinopril 1 mg/mL; naproxen 25 mg/mL; paracetamol [acetaminophen] 50 mg/mL; and sertraline hydrochloride 10 mg/mL) compounded in oral suspensions using SyrSpend SF PH4 as the vehicle throughout the study period and stored both at controlled refrigerated (2°C to 8°C) and room temperature (20°C to 25°C)...
September 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28335189/synergistic-antibacterial-effects-of-nanoparticles-encapsulated-with-scutellaria-baicalensis-and-pure-chlorhexidine-on-oral-bacterial-biofilms
#5
Ken Cham-Fai Leung, Chaminda Jayampath Seneviratne, Xuan Li, Ping Chung Leung, Clara Bik San Lau, Chi-Hin Wong, Ka Yan Pang, Chun Wai Wong, Elaine Wat, Lijian Jin
Scutellariabaicalensis (SB) is a traditional Chinese medicine for treating infectious and inflammatory diseases. Our recent study shows potent antibacterial effects of nanoparticle-encapsulated chlorhexidine (Nano-CHX). Herein, we explored the synergistic effects of the nanoparticle-encapsulated SB (Nano-SB) and Nano-CHX on oral bacterial biofilms. Loading efficiency of Nano-SB was determined by thermogravimetric analysis, and its releasing profile was assessed by high-performance liquid chromatographyusing baicalin (a flavonoid compound of SB) as the marker...
April 7, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28333668/development-of-extemporaneously-compounded-aripiprazole-oral-suspensions-for-use-in-children
#6
Lance A Pramann, Lawrence W Davidow, Leon van Haandel, Ryan S Funk
The purpose of this study was to develop extemporaneously compounded oral liquid formulations of aripiprazole for use in pediatric patients and those patients unable to swallow the solid oral dosage forms. Aripiprazole tablets(30 mg) were ground to a fine powder and suspended at a concentration of 1.0 mg/mL in either a 1:1 blend of Ora-Plus and Ora-Sweet, or 1% methylcellulose and Simple Syrup NF. Five amber, plastic liquid prescription bottles of each formulation were stored at 4°C, and aripiprazole content was measured by ultra-performance liquid chromatography time-of-flight mass spectrometry at 0, 14, 32, 67, and 91 days...
May 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28332230/screening-and-identification-of-multiple-constituents-and-their-metabolites-of-zhi-zi-chi-decoction-in-rat-urine-and-bile-by-uplc-q-tof-ms-ms
#7
Wei Feng, Qiuju Dong, Minyan Liu, Si Li, Ting Liu, Xinguo Wang, Liying Niu
Zhi-zi-chi decoction (ZZCD) is a classical formula widely used in Chinese clinical application. In the present study, a novel and efficient strategy has been developed for screening and identification of multiple constituents and their metabolites of ZZCD using ultra high performance liquid chromatography combined with triple TOF mass spectrometry. The novel approach of an on-line data acquisition method dependent on multiple mass defect filter and dynamic background subtraction is combined with multiple data processing techniques...
March 23, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28304352/in-vitro-anti-inflammatory-and-cytotoxic-effects-of-aqueous-extracts-from-the-edible-sea-anemones-anemonia-sulcata-and-actinia-equina
#8
Tânia Costa Silva, Paula Branquinho de Andrade, Fátima Paiva-Martins, Patrícia Valentão, David Micael Pereira
Marine invertebrates have been attracting the attention of researchers for their application in nutrition, agriculture, and the pharmaceutical industry, among others. Concerning sea anemones (Cnidaria), little is known regarding their metabolic profiles and potential value as a source of pharmacologically-active agents. In this work, the chemical profiles of two species of sea anemones Actinia equina and Anemonia sulcata, were studied by high-performance liquid chromatography with diode-array detection (HPLC-DAD) and its impact upon immune and gastric cells was evaluated...
March 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28296744/hypouricemic-and-arthritis-relapse-reducing-effects-of-compound-tufuling-oral-liquid-in-intercritical-and-chronic-gout-a-double-blind-placebo-controlled-multicenter-randomized-trial
#9
RANDOMIZED CONTROLLED TRIAL
Zhijun Xie, Huaxiang Wu, Xiaoqing Jing, Xiuyang Li, Yasong Li, Yongmei Han, Xiangfu Gao, Xiaopo Tang, Jing Sun, Yongshen Fan, Chengping Wen
TRIAL DESIGN: In the double-blind, randomized, controlled trial, we aimed to evaluate the effects of compound tufuling oral liquid (CoTOL) on serum uric acid (sUA) levels and recurrence of acute gouty arthritis in intercritical and chronic gout treatment. METHODS: A total of 210 patients with gout were screened from 8 hospitals to observe the sUA and acute gouty arthritis recurrence rate-reducing effects of CoTOL in intercritical and chronic gout during a 12-week treatment...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28285620/evidence-against-the-participation-of-a-pharmacokinetic-interaction-in-the-protective-effect-of-single-dose-curcumin-against-gastrointestinal-damage-induced-by-indomethacin-in-rats
#10
Liliana Zazueta-Beltrán, Lorena Medina-Aymerich, Nadia Estela Díaz-Triste, Aracely Evangelina Chávez-Piña, Gilberto Castañeda-Hernández, Leticia Cruz-Antonio
OBJECTIVE: To determine the role of a pharmacokinetic interaction in the protective effect of curcumin against the gastric damage induced by indomethacin administration as such or as its prodrug acemetacin. METHODS: Wistar rats orally received single dose of indomethacin (30 mg/kg) with and without curcumin (30 mg/kg); gastric injury was evaluated by determining the total damaged area. Additional groups of rats received an oral single dose of indomethacin (30 mg/kg) or its prodrug acemetacin (34...
March 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28284081/an-integrated-strategy-using-uplc-qtof-ms-e-and-uplc-qtof-mrm-enhanced-target-for-pharmacokinetics-study-of-wine-processed-schisandra-chinensis-fructus-in-rats
#11
Kuangyi Liu, Yonggui Song, Yali Liu, Mi Peng, Hanyun Li, Xueliang Li, Bingwei Feng, Pengfei Xu, Dan Su
Currently the pharmacokinetic (PK) research of herbal medicines is still limited and facing critical technical challenges on quantitative analysis of multi-components from biological matrices which often accompanied by lacking of authentic standards and low concentration. This present work contributes to the development of an integrated strategy for extensive pharmacokinetics assessments, and a selective and sensitive method independent of authentic standards for multi-components analysis based on the use of ultra-performance liquid chromatography/quadrupole-time-of-flight/MS(E) (UPLC-TOF-MS(E)) and UPLC-TOF-MRM (rnhanced target)...
February 27, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28273367/lc-ms-ms-method-for-simultaneous-determination-of-flavonoids-and-physalins-in-rat-plasma-application-to-pharmacokinetic-study-after-oral-administration-of-physalis-alkekengi-var-franchetii-chinese-lantern-extract
#12
Yaqing Guo, Hongxia Liu, Liqin Ding, Mahmood Oppong, Guixiang Pan, Feng Qiu
A rapid and sensitive liquid chromatography with tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of luteolin, luteolin-7-O-glucopyranoside, physalin A, physalin D and physalin L in rat plasma. Scutellarein and dexamethasone were used as the internal standards (IS). Plasma samples were prepared by liquid-liquid extraction with ethyl acetate. The five constituents were separated on an Acquity UPLC BEH C18 column (100 mm × 2.1 mm, 1.7 µm). A gradient elution procedure was used with acetonitrile(A) - 0...
March 8, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28272302/a-new-oleanolic-acid-derivative-against-ccl%C3%A2-induced-hepatic-fibrosis-in-rats
#13
Hongjun Xiang, Yaotian Han, Yuzhong Zhang, Wenqiang Yan, Bing Xu, Fuhao Chu, Tianxin Xie, Menglu Jia, Mengmeng Yan, Rui Zhao, Penglong Wang, Haimin Lei
A novel hepatoprotective oleanolic acid derivative, 3-oxours-oleana-9(11), 12-dien-28-oic acid (Oxy-Di-OA), has been reported. In previous studies, we found that Oxy-Di-OA presented the anti-HBV (Hepatitis B Virus) activity (IC50 = 3.13 µg/mL). Remarkably, it is superior to lamivudine in the inhibition of the rebound of the viral replication rate. Furthermore, Oxy-Di-OA showed good performance of anti-HBV activity in vivo. Some studies showed that liver fibrosis may affiliate with HBV gene mutations. In addition, the anti-hepatic fibrosis activity of Oxy-Di-OA has not been studied...
March 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28265851/evaluation-of-antinociceptive-and-anti-inflammatory-effects-of-aqueous-extract-of-armadillidium-vulgare-latreille
#14
Shen-Shen Guo, Meng-Yue Ren, Shuai Song, Ping Wei, Jia-Bo Luo
OBJECTIVE: To assess the antinociceptive and anti-inflammatory properties of the aqueous extract of Armadillidium vulgare (AV). METHODS: The antinociceptive effect of AV (400, 600 and 800 mg/kg) was investigated in mice using the acetic acid-induced writhing, formalin-induced nociceptive, and hot plate tests. Phlogogen-induced paw edema using carrageenan, dextran, or compound 48/80 as phlogogen was used as inflammatory models to evaluate AV's anti-inflammatory effect...
February 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28262508/the-role-of-ntcp-oatp2-bsep-and-mrp2-in-liver-injury-induced-by-dioscorea-bulbifera-l-and-diosbulbin-b-in-mice
#15
Xiao-Yu Qu, Li-Na Tao, Si-Xi Zhang, Jing-Meng Sun, Jun-Qi Niu, Yan-Hua Ding, Yan-Qing Song
Dioscorea bulbifera L. (DB) is a traditional Chinese herb used in thyroid disease and cancer. However, the clinical use of DB remains a challenge due to its hepatotoxicity, which is caused, in part, by the presence of Diosbulbin B (DIOB), a toxin commonly found in DB extracts. As abnormal expression of hepatobiliary transporters plays an important role in drug-induced liver injury, we assessed the hepatotoxicity induced by DB and DIOB, and explored their impacts on hepatobiliary transporter expression levels...
February 28, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28254113/development-and-in%C3%A2-vivo-evaluation-of-self-microemulsion-as-delivery-system-for-%C3%AE-mangostin
#16
Wen-Ke Xu, Hui Jiang, Kui Yang, Ya-Qin Wang, Qian Zhang, Jian Zuo
α-Mangostin (MG) is a versatile bioactive compound isolated from mangosteen and possesses significant pharmacokinetic shortages. To augment the potential clinical efficacy, MG-loaded self-microemulsion (MG-SME) was designed and prepared in this study, and its potential as a drug loading system was evaluated based on the pharmacokinetic performance and tissue distribution feature. The formula of MG-SME was optimized by an orthogonal test under the guidance of ternary phase diagram, and the prepared MG-SME was characterized by encapsulation efficiency, size distribution, and morphology...
March 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28243062/oral-and-transdermal-drug-delivery-systems-role-of-lipid-based-lyotropic-liquid-crystals
#17
REVIEW
Rajan Rajabalaya, Muhammad Nuh Musa, Nurolaini Kifli, Sheba R David
Liquid crystal (LC) dosage forms, particularly those using lipid-based lyotropic LCs (LLCs), have generated considerable interest as potential drug delivery systems. LCs have the physical properties of liquids but retain some of the structural characteristics of crystalline solids. They are compatible with hydrophobic and hydrophilic compounds of many different classes and can protect even biologicals and nucleic acids from degradation. This review, focused on research conducted over the past 5 years, discusses the structural evaluation of LCs and their effects in drug formulations...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28236316/simultaneous-determination-of-wogonin-oroxylin-a-schisandrin-paeoniflorin-and-emodin-in-rat-serum-by-hplc-ms-ms-and-application-to-the-pharmacokinetic-studies
#18
Minting Chen, Suying Wei, Chaohua Luo, Feilong Chen, Shuai Song, Qun Shen, Zhixian Mo, Fenghuan Wei
Wogonin and oroxylin A in Scutellariae Radix, schisandrin in Chinensis fructus, paeoniflorin in Moutan Cortex and emodin in Polygoni Cuspidate Rhizome et Radix are anti-inflammatory active compounds. A method for simultaneous determination of the five compounds in rat was developed and validated using high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The separation was performed on a Symmetry C18 column (4.6 × 50 mm, 3.5 µm) with acetonitrile and 0.1% formic acid aqueous solution as the mobile phases...
February 24, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28223118/characterization-of-the-dinophysistoxin-2-acute-oral-toxicity-in-mice-to-define-the-toxicity-equivalency-factor
#19
Paula Abal, M Carmen Louzao, José Manuel Cifuentes, Natalia Vilariño, Ines Rodriguez, Amparo Alfonso, Mercedes R Vieytes, Luis M Botana
Ingestion of shellfish with dinophysistoxin-2 (DTX2) can lead to diarrheic shellfish poisoning (DSP). The official control method of DSP toxins in seafood is the liquid chromatography-mass spectrometry analysis (LC-MS). However in order to calculate the total toxicity of shellfish, the concentration of each compound must be multiplied by individual Toxicity Equivalency Factor (TEF). Considering that TEFs caused some controversy and the scarce information about DTX2 toxicity, the aim of this study was to characterize the oral toxicity of DTX2 in mice...
April 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28216902/feeble-antipyretic-analgesic-and-anti-inflammatory-activities-were-found-with-regular-dose-4-o-%C3%AE-d-glucosyl-5-o-methylvisamminol-one-of-the-conventional-marker-compounds-for-quality-evaluation-of-radix-saposhnikoviae
#20
Jing-Ming Yang, Hua Jiang, Hong-Liang Dai, Zi-Wei Wang, Gui-Zhi Jia, Xiang-Cai Meng
INTRODUCTION: 4'-O-β-D-glucosyl-5-O-methylvisamminol (GML) is a conventional marker compound for quality control of Radix Saposhnikoviae. Despite that, neither pharmacodynamic or pharmacokinetic information is available with regard to GML. As such, the aim of thisstudy was to assess the conventional evaluation indices for the quality of Radix Saposhnikoviae. MATERIALS AND METHODS: Pyretic animal model, hot plate test, and ear edema model were established to evaluate and compare the antipyretic, analgesic, and anti-inflammatory effect of the chromone derivativescimifugin, prime-O-glucosylcimifugin (PGCN), and GML in Radix Saposhnikoviae...
January 2017: Pharmacognosy Magazine
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