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Oral suspensions

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https://www.readbyqxmd.com/read/28208830/cefdinir-solid-dispersion-composed-of-hydrophilic-polymers-with-enhanced-solubility-dissolution-and-bioavailability-in-rats
#1
Hyun-Jong Cho, Jun-Pil Jee, Ji-Ye Kang, Dong-Yeop Shin, Han-Gon Choi, Han-Joo Maeng, Kwan Hyung Cho
The aim of this work was to develop cefdinir solid dispersions (CSDs) prepared using hydrophilic polymers with enhanced dissolution/solubility and in vivo oral bioavailability. CSDs were prepared with hydrophilic polymers such as hydroxypropyl-methylcellulose (HPMC; CSD1), carboxymethylcellulose-Na (CMC-Na; CSD2), polyvinyl pyrrolidone K30 (PVP K30; CSD3) at the weight ratio of 1:1 (drug:polymer) using a spray-drying method. The prepared CSDs were characterized by aqueous solubility, differential scanning calorimetry (DSC), powder X-ray diffraction (p-XRD), scanning electron microscopy (SEM), aqueous viscosity, and dissolution test in various media...
February 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28206732/clinical-efficacy-and-safety-of-a-new-once-daily-1000-mg-suspension-versus-twice-daily-500-mg-tablets-of-micronized-purified-flavonoid-fraction-in-patients-with-symptomatic-chronic-venous-disorders-a-randomized-controlled-trial
#2
Patrick Carpentier, Debora Karetova, Harunarashid Hanafiah, Elisabeth Enriquez-Vega, Andrej Dzupina, Miso Sabovic, Lourdes Reina Gutierrez, Somboom Subwongcharoen, Hasan Tüzün, Arnaud Maggioli
BACKGROUND: Chronic venous disorders (CVD) is estimated to affect 30% to 50% of women and 10% to 30% of men. The most widely prescribed treatment for CVD worldwide is micronized purified flavonoid fraction 500 mg (MPFF). The aim of this clinical trial was to develop a new once daily 1000 mg oral suspension of MPFF. METHODS: In an international, randomized, double-blind, parallel-group study, symptomatic individuals classified CEAP C0s to C4s were randomized in either treatment arm and treated for 8 weeks...
February 15, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28205322/efficacy-and-safety-of-autoinjected-exenatide-once-weekly-suspension-versus-sitagliptin-or-placebo-with-metformin-in-patients-with-type-2-diabetes-the-duration-neo-2-randomized-clinical-study
#3
Kishore M Gadde, Marion L Vetter, Nayyar Iqbal, Elise Hardy, Peter Öhman
AIMS: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors treat type 2 diabetes through incretin-signaling pathways. This study compared the efficacy and safety of the glucagon-like peptide-1 receptor agonist exenatide once-weekly (Miglyol) suspension for autoinjection (QWS-AI) with the dipeptidyl peptidase-4 inhibitor sitagliptin or placebo. MATERIALS AND METHODS: In this open-label, multicenter study of patients with type 2 diabetes who had suboptimal glycemic control on metformin monotherapy, 365 patients were randomized to receive exenatide 2...
February 16, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28188161/sildenafil-improves-clinical-signs-and-radiographic-features-in-dogs-with-congenital-idiopathic-megaoesophagus-a-randomised-controlled-trial
#4
F Quintavalla, A Menozzi, C Pozzoli, E Poli, P Donati, D K Wyler, P Serventi, S Bertini
We evaluated the efficacy of oral sildenafil citrate in dogs with congenital idiopathic megaoesophagus (CIM). Twenty-one puppies were randomly assigned to two groups (treatment and control). The dogs were given sildenafil oral suspension 1 mg/kg every 12 hours for 14 days or placebo in a masked fashion. Clinical signs (frequency of regurgitation and weight gain) and oesophagrams (relative oesophageal diameter, ROD) were evaluated in order to assess the efficacy of drug treatment, by examiners who were unaware of the study protocol...
February 10, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28179525/differentiation-dependent-lmp1-expression-is-required-for-efficient-lytic-ebv-reactivation-in-epithelial-cells
#5
Dhananjay M Nawandar, Makoto Ohashi, Reza Djavadian, Elizabeth Barlow, Kathleen Makielski, Ahmed Ali, Denis Lee, Paul F Lambert, Eric Johannsen, Shannon C Kenney
Epstein-Barr virus (EBV)-associated diseases of epithelial cells, including tumors such as nasopharyngeal carcinoma (NPC) that have latent infection, and oral hairy leukoplakia (OHL) lesions that have lytic infection, frequently express the viral latent membrane protein 1 (LMP1). In lytically-infected cells, LMP1 expression is activated by the BRLF1 (R) immediate-early (IE) protein. However, the mechanisms by which LMP1 expression is normally regulated in epithelial cells remain poorly understood, and its potential roles in regulating lytic reactivation in epithelial cells are as yet unexplored...
February 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28170182/primary-salivary-human-stem-progenitor-cells-undergo-microenvironment-driven-acinar-like-differentiation-in-hyaluronate-hydrogel-culture
#6
Padma Pradeepa Srinivasan, Vaishali N Patel, Shuang Liu, Daniel A Harrington, Matthew P Hoffman, Xinqiao Jia, Robert L Witt, Mary C Farach-Carson, Swati Pradhan-Bhatt
Radiotherapy for head and neck cancer often has undesirable effects on salivary glands that lead to xerostomia or severe dry mouth, which can increase oral infections. Our goal is to engineer functional, three-dimensional (3D) salivary gland neotissue for autologous implantation to provide permanent relief. An immediate need exists to obtain autologous adult progenitor cells as the use of embryonic and induced pluripotent stem cells potentially pose serious risks such as teratogenicity and immunogenic rejection...
January 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28169546/colloidal-vesicular-system-of-inositol-hexaphosphate-to-counteract-dmba-induced-dysregulation-of-markers-pertaining-to-cellular-proliferation-differentiation-and-inflammation-of-epidermal-layer-in-mouse-model
#7
Malti Arya, Prakash Tiwari, Chandra Bhushan Tripathi, Poonam Parashar, Mahendra Singh, Priyam Sinha, Narayan P Yadav, Gaurav Kaithwas, Krishna P Gupta, Shubhini A Saraf
Cancer is a global health problem and chemoprevention is a promising approach for reducing cancer burden. Inositol hexaphosphate (IP6), a natural bioactive constituent of cereals, legumes etc., has momentous potential as an antiangiogenic agent, that specifically affects malignant cells. The shortcoming is its quick absorption on oral/ topical administration. Niosomes are flexible carriers for topical drug delivery. The central venture of current research was to optimize and characterize niosomal delivery system of IP6 for treatment of skin cancer...
February 7, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28165806/enhancing-both-oral-bioavailability-and-brain-penetration-of-puerarin-using-borneol-in-combination-with-preparation-technologies
#8
Tao Yi, Dandan Tang, Fan Wang, Jiqiong Zhang, Jiao Zhang, Jirui Wang, Xiaoyu Xu, Jifen Zhang
Now there are few good oral preparations of puerarin used in cerebrovascular diseases because of its poor oral absorption caused by the low water solubility and the poor penetration into brain. In this study, three oral formulations of puerarin, nanocrystals suspension (NCS), inclusion compounds solution (ICS) and self-microemulsifying drug delivery system (SMEDDS) were prepared with borneol as an oral brain-targeting enhancer. A rat syngeneic in vitro model of the brain-blood barrier (BBB) was established to investigate effects of borneol on the permeability of puerarin across the BBB...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28165798/improving-anti-tumor-activity-of-sorafenib-tosylate-by-lipid-and-polymer-coated-nanomatrix
#9
Yang Guo, Ting Zhong, Xiao-Chuan Duan, Shuang Zhang, Xin Yao, Yi-Fan Yin, Dan Huang, Wei Ren, Qiang Zhang, Xuan Zhang
In the present study, we select the Sylysia 350 (Sylysia) as mesoporous material, distearoylphosphatidylethanolamine-poly(ethylene glycol)2000 (DSPE-PEG) as absorption enhancer and hydroxy propyl methyl cellulose (HPMC) as crystallization inhibitor to prepare sorafenib tosylate (SFN) nanomitrix (MSNM@SFN) for improving the anti-tumor activity of SFN. The MSNM@SFN was prepared by solvent evaporation method. The solubility, dissolution, and bioavailability of SFN in MSNM@SFN were also investigated. The anti-tumor activity of MSNM@SFN was evaluated in vitro and in vivo...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28161984/formulation-of-piperine-solid-lipid-nanoparticles-sln-for-treatment-of-rheumatoid-arthritis
#10
M R Bhalekar, A R Madgulkar, Puja S Desale, Gyce Marium
The purpose of this work was to formulate piperine solid lipid nanoparticle (SLN) dispersion to exploit its efficacy orally and topically. Piperine-SLN were prepared by melt emulsification method and formula was optimized by the application of 3(2) factorial design. The nanoparticulate dispersion was evaluated for particle size, entrapment efficiency (EE) and zeta potential(ZP). Optimized batch (128.80 nm average size, 78.71% EE and -23.34 Mv Zeta Potential) was characterized for differential scanning calorimetry (DSC), X-ray diffraction(XRD) which revealed amorphous nature of piperine in SLN...
February 6, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28156176/respirable-controlled-release-polymeric-colloid-rcrpc-of-bosentan-for-the-management-of-pulmonary-hypertension-in-vitro-aerosolization-histological-examination-and-in-vivo-pulmonary-absorption
#11
Lydia A Hanna, Emad B Basalious, Omaima N ELGazayerly
Bosentan is an endothelin receptor antagonist (ERA) prescribed for patients with pulmonary arterial hypertension (PAH). The oral delivery of bosentan possesses several drawbacks such as low bioavailability (about 50%), short duration of action, frequent administration, hepatotoxicity and systemic hypotension. The pulmonary administration would circumvent the pre-systemic metabolism thus improving the bioavailability and avoids the systemic adverse effects of oral bosentan. However, the short duration of action and the frequent administration are the major drawbacks of inhalation therapy...
November 2016: Drug Delivery
https://www.readbyqxmd.com/read/28154011/involvement-of-gut-microbiota-in-the-association-between-glp-1-glp-1-receptor-expression-and-gastrointestinal-motility
#12
Mo Yang, Hirokazu Fukui, Hirotsugu Eda, Xin Xu, Yoshitaka Kitayama, Ken Hara, Mio Kodani, Toshihiko Tomita, Tadayuki Oshima, Jiro Watari, Hiroto Miwa
Microbiota in the gut is known to play a pivotal role in host physiology by interacting with the immune and neuroendocrine systems in gastrointestinal (GI) tissues. Glucagon-like peptide 1 (GLP-1), a gut hormone, is involved in metabolism as well as GI motility. We examined how gut microbiota affects the link between GLP-1/GLP-1 receptor (GLP-1R) expression and motility of the GI tract. Germ-free (GF) mice (6 weeks old) were orally administered a fecal bacterial suspension prepared from specific pathogen-free (SPF) mice, and then after fecal transplantation (FT) GI tissues were obtained from the GF mice at various time points...
February 2, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28152481/in-vivo-evaluation-of-a-self-nanoemulsifying-drug-delivery-system-for-curcumin
#13
R Nazari-Vanani, L Moezi, H Heli
Curcumin has attracted particular attention in recent years due to its great variety of beneficial biological and pharmacological activities. However, its efficacy has been limited due to its low bioavailability, and this limitation can be overcome by novel drug delivery systems. Self-nanoemulsifying drug delivery system (SNEDDS) is a novel route to improve oral bioavailability of lipophilic drugs. SNEDDS spontaneously forms fine oil-in-water nanoemulsion by mild agitation. An optimal formula for a SNEDDS comprised ethyl oleate:tween 80:PEG 600 (50:40:10% w/w) with 11...
January 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28151825/current-trends-in-upper-and-lower-eyelid-blepharoplasty-among-american-society-of-ophthalmic-plastic-and-reconstructive-surgery-members
#14
Andrea L Kossler, Grace L Peng, Donald B Yoo, Babak Azizzadeh, Guy G Massry
PURPOSE: To assess current practice patterns for management of upper and lower eyelid blepharoplasty by active American Society of Ophthalmic Plastic and Reconstructive Surgery members. METHODS: An invitation to participate in a web-based anonymous survey was sent to the active American Society of Ophthalmic Plastic and Reconstructive Surgery membership via email. The survey consists of 34 questions, both multiple choice and free response, regarding upper and lower eyelid blepharoplasty surgery...
February 1, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28134229/-interaction-of-oral-form-anticancer-drugs-with-grapefruit-juice
#15
REVIEW
Magdalena Cholewka-Stafińska, Renata Polaniak, Marek Kardas, Mateusz Grajek, Elżbieta Grochowska-Niedworok
Oral medication (tablets, capsules, suspensions, liquids, etc.) are frequently used in therapy. This may arise due to the fact that oral medication patient can take at home and it reduce the stress associated with taking the drug. On the Polish pharmaceutical market can be observed more frequent registration to trading anticancer drugs in oral form. Is also growing interest about drug interactions with food, but they are still less accented than drug-drug interactions. The results of pharmacokinetic studies on the interaction of drugs used in antineoplastic therapy with food are particularly important because of the characteristics of cancer patients, and a growing number of people suffering from cancer and which may have a problem...
January 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28132566/long-term-comparative-pharmacovigilance-of-orally-transmitted-chagas-disease-first-report
#16
Belkisyolé Alarcón de Noya, Raiza Ruiz-Guevara, Oscar Noya, Julio Castro, John Ossenkopp, Zoraida Díaz-Bello, Cecilia Colmenares, José Antonio Suárez, Oscar Noya-Alarcón, Laura Naranjo, Humberto Gutiérrez, Giuseppa Quinci, Jaime Torres
BACKGROUND: Two old drugs are the only choice against Trypanosoma cruzi and little is known about their secondary effects in the acute stage of oral-transmitted Chagas disease (ChD). METHODS: A cross-sectional analytical surveillance study was conducted in a sizable cohort of patients seen during the largest acute foodborne ChD microepidemic registered so far. Individuals were treated with benznidazole (BNZ) or nifurtimox (NFX). "Common Terminology Criteria for Adverse Events" was assessed to categorize side effects according to severity...
January 30, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28130762/new-formulations-of-methylphenidate-for-the-treatment-of-attention-deficit-hyperactivity-disorder-pharmacokinetics-efficacy-and-tolerability
#17
REVIEW
Samuele Cortese, Giulia D'Acunto, Eric Konofal, Gabriele Masi, Benedetto Vitiello
Psychostimulants are the recommended first-line pharmacological treatment for attention-deficit/hyperactivity disorder (ADHD). Methylphenidate is one of the most commonly used psychostimulants worldwide. Given that immediate-release and/or tablet/capsule formulations may decrease adherence to methylphenidate treatment, several drug companies have been developing novel long-acting and/or liquid/chewable formulations that may improve adherence as well as (for long-acting formulations) reduce abuse potential, decrease stigma associated with multiple administrations per day, and decrease the potential for adverse effects related to dosage peak...
February 2017: CNS Drugs
https://www.readbyqxmd.com/read/28126184/-breaking-paradigms-intestinal-microbiota-transplantation-preliminar-report
#18
Álvaro Zamudio-Tiburcio, Héctor Bermúdez-Ruiz, Hugo Ricardo Lezama-Guzmán, María Del Pilar Guevara-Ortigoza, Elena Islas-Solares, Francisco Antonio Sosa-López
In the fourth century, during the Chinese Dong Jin dynasty, the doctor Ge Hong described good results after the oral administration of a suspension prepared from human faeces in patients with severe diarrhoea or food poisoning. Faecal microbiota transplantation has been used for five years in order to treat different diseases in addition to the severe diarrhoea caused by Clostridium difficile(1). This paper aims to confirm that intestinal microbiota transplantation succeeds in reducing the negative impact of diseases such as severe diarrhoea, irritable bowel syndrome, anxiety, allergies, metabolic syndrome and others and that it is not only indicated for severe diarrhoea caused by C...
January 23, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28123991/enhanced-bioavailability-of-danazol-nanosuspensions-by-wet-milling-and-high-pressure-homogenization
#19
Naveen Kanthamneni, Satyanarayana Valiveti, Mita Patel, Heather Xia, Yin-Chao Tseng
INTRODUCTION: The majority of drugs obtained through synthesis and development show poor aqueous solubility and dissolution velocity, resulting in reduced bioavailability of drugs. Most of these problems arise from formulation-related performance issues, and an efficient way to overcome these obstacles and to increase dissolution velocity is to reduce the particle size of drug substances to form drug nanosuspensions. MATERIALS AND METHODS: Danazol nanosuspensions were prepared by wet milling (WM) and high-pressure homogenization (HPH) methods...
October 2016: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28119098/anti-inflammatory-effects-of-brucea-javanica-oil-emulsion-by-suppressing-nf-%C3%AE%C2%BAb-activation-on-dextran-sulfate-sodium-induced-ulcerative-colitis-in-mice
#20
Yan-Feng Huang, Jiang-Tao Zhou, Chang Qu, Yao-Xing Dou, Qiong-Hui Huang, Zhi-Xiu Lin, Yan-Fang Xian, Jian-Hui Xie, You-Liang Xie, Xiao-Ping Lai, Zi-Ren Su
ETHNOPHARMACOLOGICAL RELEVANCE: Brucea javanica is an important traditional medicinal herb used for the treatment of dysentery, malaria, inflammation and cancer in southeast Asia for many years. However, the anti-inflammatory mechanism of Brucea javanica in the treatment of dysentery (also known as ulcerative colitis, UC) has not been fully illuminated. Brucea javanica oil emulsion (BJOE) is the major active and most common application form of Brucea javanica oil (BJO), which has a variety of pharmacological activities...
January 21, 2017: Journal of Ethnopharmacology
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