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Oral suspensions

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https://www.readbyqxmd.com/read/29767471/converting-immunosuppression-from-an-oral-suspension-to-a-granule-formulation-of-tacrolimus-in-pediatric-renal-transplant-recipients
#1
Georgia Malakasioti, Christine Booth, Stephen D Marks
OS of tacrolimus prepared from tacrolimus powder is not licensed for children. A licensed GF for OS allows flexibility for body weight-based dose adjustments. This study aimed at exploring the efficacy of conversion from OS to the GF of tacrolimus in stable pediatric renal transplant recipients. Records of 25 pediatric renal transplant recipients aged under 18 years who were switched from an unlicensed tacrolimus OS to GF were reviewed. At day 0, 1 week, and 4-8 weeks post-conversion, there were no differences regarding daily tacrolimus dose (3...
May 16, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29755912/scrotal-rejuvenation
#2
REVIEW
Philip R Cohen
Genital rejuvenation is applicable not only to women (vaginal rejuvenation) but also to men (scrotal rejuvenation). There is an increased awareness, reflected by the number of published medical papers, of vaginal rejuvenation; however, rejuvenation of the scrotum has not received similar attention in the medical literature. Scrotal rejuvenation includes treatment of hair-associated scrotal changes (alopecia and hypertrichosis), morphology-associated scrotal changes (wrinkling and laxity), and vascular-associated scrotal changes (angiokeratomas)...
March 13, 2018: Curēus
https://www.readbyqxmd.com/read/29755551/antidepressant-like-effect-of-a-chalcone-compound-dhipc-and-its-possible-mechanism
#3
Dong-Hai Zhao, Yan-Chun Wang, Lian-Wen Zheng, Bing-Yu Liu, Li-Ping Guan
DHIPC (2,4-dichloro-2´-hydroxyl-4´,6´-diisoprenyloxychalcone) is a new chalcone compound. In this study, its antidepressant-like activity of compound DHIPC was evaluated by the forced swimming test and the tail suspension test in mice. The results showed that DHIPC significantly reduced the immobility time for 2 h after treatment through the oral administration at dose of 10, 20, and 30 mg/kg in the forced swimming test and the tail suspension test, indicating a significant antidepressant-like effect. The maximal effect was obtained at 30 mg/kg, which is similar to the positive control fluoxetine...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29753956/smart-gated-magnetic-silica-mesoporous-particles-for-targeted-colon-drug-delivery-new-approaches-for-inflammatory-bowel-diseases-treatment
#4
Adrián H Teruel, Édgar Pérez-Esteve, Isabel González-Álvarez, Marta González-Álvarez, Ana M Costero, Daniel Ferri, Margarita Parra, Pablo Gaviña, Virginia Merino, Ramón Martínez-Mañez, Félix Sancenón
Magnetic mesoporous silica microparticles were loaded with safranin O (S1) and with hydrocortisone (S2) and the outer surface functionalized with a bulky azo derivative bearing urea moieties. Aqueous suspensions of both solids at pH 7.4 showed negligible payload release whereas a marked delivery was observed in the presence of sodium dithionite due to the rupture of the azo bonds. Besides, a moderate cargo release was observed at acidic pH due to the hydrolysis of the urea bonds that linked the azo derivative onto the external surface of the inorganic scaffolds...
May 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29747745/the-potential-effect-of-garlic-extract-and-curcumin-nanoparticles-against-complication-accompanied-with-experimentally-induced-diabetes-in-rats
#5
Afaf D Abdel-Mageid, Mohamed E S Abou-Salem, Nancy M H A Salaam, Hoda A S El-Garhy
BACKGROUND: Modified herbal medicines implicate the combination of several therapeutic practices of native systems of medicine that may extend many earlier generations, which frequently afford valuable therapeutic benefits. PURPOSE: In this study, the role of nano-curcumin and aged garlic extract (AGE) as two modified phytomedicines on alleviating both of advanced glycation end products (AGEPs) and oxidative stress (OS) in streptozotocin (STZ) induced diabetic rats were investigated during this study...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29746955/micafungin-versus-posaconazole-prophylaxis-in-acute-leukemia-or-myelodysplastic-syndrome-a-randomized-study
#6
David J Epstein, Susan K Seo, Yao-Ting Huang, Jay H Park, Virginia M Klimek, Ellin Berman, Martin S Tallman, Mark G Frattini, Genovefa A Papanicolaou
OBJECTIVES: To compare the effectiveness and tolerability of micafungin versus posaconazole during chemotherapy-induced neutropenia in acute leukemia (AL) and myelodysplastic syndrome (MDS). METHODS: Patients with AL or MDS undergoing chemotherapy were randomized to open-label micafungin 100 mg intravenously daily or posaconazole suspension 400 mg orally twice daily until neutrophil recovery, up to 28 days. Patients were followed for 12 weeks. The primary endpoint was prophylaxis failure (premature discontinuation due to infection, intolerance, adverse event, or death)...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29737955/comparison-of-two-neutral-oral-contrast-agents-in-pediatric-patients-a-prospective-randomized-study
#7
Jonathan R Dillman, Alexander J Towbin, Rebecca Imbus, Julie Young, Erica Gates, Andrew T Trout
Purpose To prospectively compare small bowel distention provided by, as well as patient acceptance of, two different neutral (negative) oral contrast materials used for cross-sectional enterography in a pediatric population. Materials and Methods In this noninferiority study, 66 pediatric patients undergoing clinical computed tomographic (CT) or magnetic resonance (MR) enterography were randomized to receive either a flavored beverage for neutral abdominal and pelvic imaging (Breeza; Beekley Medical, Bristol, Conn) or a low-density barium sulfate suspension...
May 8, 2018: Radiology
https://www.readbyqxmd.com/read/29736050/stability-of-dapsone-in-extemporaneously-compounded-oral-suspensions
#8
Hugo Alarie, M Mihaela Friciu, Grégoire Leclair
No abstract text is available yet for this article.
March 2018: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/29730322/salt-formation-improved-the-properties-of-a-candidate-drug-during-early-formulation-development
#9
Kalle Sigfridsson, Matti Ahlqvist, Martin Lindsjö, Stefan Paulsson
The purpose of this study was to investigate if AZD5329, a dual neurokinin NK1/2 receptor antagonist, is a suitable candidate for further development as an oral immediate release (IR) solid dosage form as a final product. The neutral form of AZD5329 has only been isolated as amorphous material. In order to search for a solid material with improved physical and chemical stability and more suitable solid-state properties, a salt screen was performed. Crystalline material of a maleic acid salt and a fumaric acid salt of AZD5329 were obtained...
May 3, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29726648/-effects-of-zhibai-dihuang-decoction-on-mitochondrial-cytochrome-oxidase-in-the-spermatogenic-cells-of-rats-with-ureaplasma-urealyticum-infection
#10
Jun-Hua Guo, Ying-Qiu Li, Xuan-Zuo Guo, Chao-Sheng Liu, Qing-Hu He
Objective: To explore the effects of Zhibai Dihuang Decoction (ZDD) on mitochondrial cytochrome oxidase (COX) in the spermatogenic cells of rats with ureaplasma urealyticum (UU) infection. METHODS: From forty 4-5 months old SD rats, 30 were randomly selected for the establishment of the model of testicular UU infection by inoculating the bladder with UU suspension and the other 10 injected with normal saline as controls (group A). At 7 days after inoculation, the rat models of testicular UU infection were treated orally with normal saline (group B), ZDD at 1 g per kg of the body weight per day (group C), and azithromycin at 0...
August 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29719365/pharmaceutical-approval-update
#11
Mary Choy
Vancomycin hydrochloride for oral solution (Firvanq) for C. difficile -associated diarrhea and enterocolitis caused by S. aureus ; dexamethasone intraocular suspension 9% (Dexycu) for the treatment of inflammation after eye surgery; and apalutamide (Erleada) for prostate cancer.
May 2018: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/29713493/prophylaxis-of-acute-respiratory-infections-via-improving-the-immune-system-in-late-preterm-newborns-with-e-coli-strain-nissle-1917-a-controlled-pilot-trial
#12
Mykola L Aryayev, Liudmyla I Senkivska, Nataliya K Bredeleva, Irina V Talashova
Background: Acute respiratory infections (ARIs), caused by the high level of immaturity of the immune system, are a major cause of morbidity in preterm newborns. The probiotic Escherichia coli strain Nissle 1917 (EcN) is well known for its immuno-modulatory properties and may therefore enhance the immune competence. Thus, EcN administration may provide a promising possibility to decrease the risk of ARIs in this vulnerable group of children. However, clinical data supporting or refuting this hypothesis are, to our knowledge, not available...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29703430/relative-bioavailability-of-methylphenidate-extended-release-chewable-tablets-chewed-versus-swallowed-whole
#13
Richat Abbas, Ann C Childress, Praneeta Nagraj, Richard Rolke, Sally A Berry, Donna R Palumbo
PURPOSE: Methylphenidate hydrochloride extended-release chewable tablet (MPH ERCT) is approved for treatment of attention deficit hyperactivity disorder in patients aged 6 years and older. This article evaluates the pharmacokinetic parameters and relative bioavailability of MPH ERCT when chewed versus swallowed whole. METHODS: In this open-label, single-dose, 3-period, 3-treatment crossover study, 12 healthy adult volunteers were randomly assigned to treatment sequence...
April 24, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29694333/effect-of-taste-masking-technology-on-fast-dissolving-oral-film-dissolution-rate-and-bioavailability
#14
Ying Zhu, Xinru You, Keqing Huang, Faisal Raza, Xin Lu, Yuejian Chen, Arvind Dhinakar, Yuan Zhang, Yang Kang, Jun Wu, Liang Ge
Fast dissolving oral film is a stamp-style drug loaded polymer film with rapid disintegration and dissolution. This new kind of drug delivery system has harsh requirements on the taste-masking technology. Suspension intermediate and liposome intermediate were prepared respectively for the formulation of two kinds of fast dissolving oral films with aim of studying the effect of taste masking technology on bioavailability of oral films and loratadine was selected as the model drug. The surface pH of films was close to neutral without oral mucosal irritation or side effects...
April 25, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29693038/successful-treatment-of-cerebral-toxoplasmosis-using-pyrimethamine-oral-solution-compounded-from-inexpensive-bulk-powder
#15
Hayley A Hodgson, Taeyong Sim, Hemil Gonzalez, Mariam Aziz, Yoona Rhee, Paul O Lewis, Neel Jhobalia, Beth Shields, Sheila K Wang
A price increase of pyrimethamine tablets in the United States has made the life-saving drug difficult to acquire for hospitalized patients who need it most. We report the successful use of a pyrimethamine oral suspension compounded from an economical bulk powder in a patient with acute toxoplasmic encephalitis.
April 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29691267/stability-of-extemporaneously-prepared-cinacalcet-oral-suspensions
#16
Kara Thomson, David J Hutchinson, Lipika Chablani
PURPOSE: The stability of extemporaneously prepared cinacalcet suspensions over 90 days was evaluated. METHODS: Cinacalcet 5-mg/mL suspension was prepared by triturating 30-mg cinacalcet tablets. Twelve 30-mL batches were prepared with a 1:1 mixture of Ora-Plus and either Ora-Sweet or Ora-Sweet SF (sugar free). Three suspensions of each kind were stored at both room temperature and refrigerated conditions. A 1-mL sample was taken from each bottle at 0, 7, 18, 32, 64, and 90 days...
May 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29688077/comparative-study-of-nisoldipine-loaded-nanostructured-lipid-carriers-and-solid-lipid-nanoparticles-for-oral-delivery-preparation-characterization-permeation-and-pharmacokinetic-evaluation
#17
Narendar Dudhipala, Karthik Yadav Janga, Thirupathi Gorre
Nisoldipine (ND) has low oral bioavailability (5%) due to first-pass metabolism. Previously, solid lipid nanoparticles (SLNs) of ND were reported. In this study, nanostructured lipid carriers (NLCs) of ND are developed to enhance the oral bioavailability. ND-NLCs were prepared using hot homogenization-ultrasonication method, using oleic acid and trimyristate as liquid lipid and solid lipid, respectively. Prepared NLCs are evaluated for an optimal system using measuring size, zeta potential, entrapment efficiency, in-vitro release and in-situ absorption studies...
April 24, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29684813/metabolite-characterization-of-ambrisentan-in-in-vitro-and-in-vivo-matrices-by-uhplc-qtof-ms-ms-detection-of-glutathione-conjugate-of-epoxide-metabolite-evidenced-by-in-vitro-gsh-trapping-assay
#18
P Johnsi Rani, Chiguru Vishnuvardhan, Rakesh D Nimbalkar, Prabha Garg, N Satheeshkumar
The focus of the present study is on in vitro and in vivo metabolite identification of ambrisentan (AMBR) a selective endothelin type - A (ETA) receptor antagonist using quadruple time-of-flight mass spectrometry (QTOF/MS). in vitro metabolism study was conducted by incubating AMBR in rat liver microsomes (RLM), rat and human liver S9 fractions. In vivo study was carried out through the collection of urine, faeces and plasma samples at various time points after oral administration of AMBR in suspension form at a dose of 25 mg/kg to six male Sprague - Dawley (SD) rats...
April 12, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29677541/tert-butyl-4-1-phenyl-1h-pyrazol-4-yl-methyl-piperazine-1-carboxylate-lqfm104-new-piperazine-derivative-with-antianxiety-and-antidepressant-like-effects-putative-role-of-serotonergic-system
#19
Dayane Moreira da Silva, Germán Sanz, Boniek Gontijo Vaz, Flávio Silva de Carvalho, Luciano Morais Lião, Danillo Ramos de Oliveira, Lorrane Kelle da Silva Moreira, Carina Sofia Cardoso, Adriane Ferreira de Brito, Daiany Priscilla Bueno da Silva, Fabio Fagundes da Rocha, Ianca Gontijo Cavalcante Santana, Pablinny Moreira Galdino, Elson Alves Costa, Ricardo Menegatti
The piperazine derivatives correspond to an extensive chemical class of compounds with numerous neuropharmacological activities, including antidepressant (e.g., nefazodone, trazodone) and anxiolytic (e.g., buspirone) properties. Therefore, aiming to identify a new antidepressant and antianxiety lead-compound, our group designed, synthesized, and investigated the effects of a new piperazine compound, namely, LQFM104, on the behavior of mice. Male albino Swiss mice were treated with LQFM104 prior to predictive behavioral tests as open field (OFT), elevated plus maze (EPM), forced swimming (FST), and tail suspension tests (TST)...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29674001/in-vitro-assessment-of-competitive-and-time-dependent-inhibition-of-the-nevirapine-metabolism-by-nortriptyline-in-rats
#20
Iris Usach, José-Maria Ferrer, José-Esteban Peris
Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1) widely used as a component of High Active Antiretroviral Therapy (HAART) since it is inexpensive, readily absorbed after oral administration and non-teratogenic. In the present work, the mechanism of a previously described pharmacokinetic interaction between NVP and the antidepressant drug nortriptyline (NT) was studied using rat hepatic microsomes. The obtained results showed a competitive inhibition of the NVP metabolism by NT...
April 16, 2018: Biochemical Pharmacology
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