keyword
MENU ▼
Read by QxMD icon Read
search

Oral suspensions

keyword
https://www.readbyqxmd.com/read/29348099/spray-dried-curcumin-nanoemulsion-a-new-road-to-improvement-of-oral-bioavailability-of-curcumin
#1
Liandong Hu, Qiaofeng Hu, Chenchen Yang
In this study a new soluble solid curcumin nanoemulsion powder was prepared using spray-drying technology to improve the solubility and bioavailability of curcumin. The liquid nanoemulsion consisted of curcumin, Capryol 90, Transcutol P, and Cremophor RH40. The solid nanoemulsion was prepared by spray-drying the liquid nanoemulsion in laboratory spray dryer, using lactose as solid carrier. The in vitro release from powder formulation was 97.6% within 15 min while the release from the curcumin crystalline was about 10%...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29338580/paeonol-nanoemulsion-for-enhanced-oral-bioavailability-optimization-and-mechanism
#2
Sufei Chen, Jing Zhang, Lei Wu, Hongfei Wu, Min Dai
AIM: The aim of this work was to optimize a nanoemulsion formulation and explain its absorption mechanism in improving the oral bioavailability of paeonol. METHOD: The bioavailability of paeonol was compared between paeonol nanoemulsion group and paeonol suspension group. The in situ single-pass intestine perfusion method, in vitro everted gut sacs method, Western blot analysis and Caco-2 cell transport studies were used to investigate the absorption mechanism of nanoemulsion...
January 17, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29337457/-pharmacovigilance-update
#3
Françoise Livio
The main pharmacovigilance updates in 2017 are reviewed. Denosumab : rebound-associated multiple vertebral fractures after discontinuation. Canagliflozine: increased risk of foot/leg amputations. Biologic and targeted cancer therapies, direct-acting antivirals for chronic hepatitis C: risk of hepatitis B reactivation. Checkpoint inhibitors : immune-related adverse events and graft rejection. Fingolimod : rebound-associated reactivation of MS following withdrawal. Daclizumab: risk of severe liver injury leading to restricted use in MS patients...
January 10, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29332231/stage-specific-therapeutic-strategies-of-medication-related-osteonecrosis-of-the-jaws-a-systematic-review-and-meta-analysis-of-the-drug-suspension-protocol
#4
REVIEW
Luca Ramaglia, Agostino Guida, Vincenzo Iorio-Siciliano, Alessandro Cuozzo, Andrea Blasi, Anton Sculean
OBJECTIVE: The most debated topic about medication-related osteonecrosis of the jaws (MRONJ) is its therapy, as there are no definitive guidelines. The aims of this systematic review were (a) to outline the best therapeutic approach according to the stage at diagnosis and (b) to perform a meta-analysis to assess whether the drug-holiday protocol may be or not an effective method in the management of MRONJ patients. MATERIALS AND METHODS: The systematic review was performed following the PRISMA principles...
January 13, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29331439/interactions-of-dimethylaminoethyl-methacrylate-copolymer-with-non-acidic-drugs-demonstrated-high-solubilization-in-vitro-and-pronounced-sustained-release-in-vivo
#5
Wiebke Saal, Nicole Wyttenbach, Jochem Alsenz, Martin Kuentz
Recent work demonstrated remarkable solubilization effects of methacrylate-copolymer Eudragit EPO (EPO) not only with acidic drugs but interestingly also with poorly soluble basic compounds. The current work studied EPO-mediated solubilization effects first in vitro using felodipine (FLP) and tamoxifen (TMX) as model compounds. EPO-containing solutions were subsequently compared in a rat pharmacokinetic study against reference solutions and suspensions. Surprisingly, solution formulations with EPO did not result in an increased relative oral bioavailability...
January 10, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29331368/in-vitro-and-in-vivo-safety-analysis-of-enterococcus-faecium-2c-isolated-from-human-breast-milk
#6
Soodabeh Khalkhali, Naheed Mojgani
INTRODUCTION: Safety analysis of probiotic bacteria is an obligatory characteristic to be evaluated prior to application in food or pharmacological products. This study was designed to evaluate in vitro and in vivo safety parameters of Enterococcus faecium 2C strain, a probiotic candidate isolated from human breast milk. MATERIAL AND METHODS: E.faecium 2C was studied for its hemolytic activity and phenotypic antibiotics resistance profile. In vivo safety of the mentioned Enterococcus strain was studied by determining acute oral toxicity in Wistar Male rats...
January 10, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29327653/preparation-and-in-vitro-and-in-vivo-evaluation-of-quercetin-loaded-mixed-micelles-for-oral-delivery
#7
Zhen Lu, Cuiping Bu, Weicheng Hu, Hui Zhang, Mengrui Liu, Meiqi Lu, Guangxi Zhai
Quercetin (QT) is a plant polyphenol with various pharmacological properties. However, the low water solubility limits its therapeutic efficacy. In the present study, QT-loaded sodium taurocholate-Pluronic P123 (QT-loaded ST/P123) mixed micelles were developed and characterized, and the effect of the formulation on improving the water solubility of QT was investigated. QT-loaded ST/P123 mixed micelles were prepared by thin film hydration-direct dissolution and optimized by uniform design. The optimal formulation possessed high drug loading (12...
January 12, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29322010/beneficiary-effect-of-commiphora-mukul-ethanolic-extract-against-high-fructose-diet-induced-abnormalities-in-carbohydrate-and-lipid-metabolism-in-wistar-rats
#8
Ramesh Bellamkonda, Rasineni Karuna, Bongu Sasi Bhusana Rao, Ketham Haritha, Bengeppagari Manjunatha, Somavarapu Silpa, Desireddy Saralakumari
The present study was proposed to elucidate the effect of Commiphora mukul gum resin elthanolic extract treatment on alterations in carbohydrate and lipid metabolisms in rats fed with high-fructose diet. Male Wistar rats were divided into four groups: two of these groups (group C and C+CM) were fed with standard pellet diet and the other two groups (group F and F+CM) were fed with high fructose (66 %) diet. C. mukul suspension in 5% Tween-80 in distilled water (200 mg/kg body weight/day) was administered orally to group C+CM and group F+CM...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29322003/preliminary-phytochemical-analysis-and-in%C3%A2-vivo-evaluation-of-antipyretic-effects-of-hydro-methanolic-extract-of-cleome-scaposa-leaves
#9
Waheed Mumtaz Abbasi, Saeed Ahmad, Sajida Perveen, Tayyeba Rehman
Cleome scaposa has been associated with the prevention of many diseases as fever, abdominal complaints and cancer. But its antipyretic effect is not reported so far. The aim of this study was to assess the efficacy of C. scaposa in reducing temperature in Baker's yeast-induced fever model of rabbits. Rabbits were randomized into 4 groups (n = 24). Fever was induced in by Saccharomyces cerevisae (3 mL/kg of 10% suspension subcutaneous) in all study groups. Afterward, group 1, 2, 3 and 4 were orally administered with paracetamol 150 mg/kg b...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29321994/the-effect-of-ethanolic-extract-of-thymus-kotschyanus-on-cancer-cell-growth-in%C3%A2-vitro-and-depression-like-behavior-in-the-mouse
#10
Mohammad-Hossein Doosti, Kazem Ahmadi, Mahdi Fasihi-Ramandi
Cancer and depression are known as two of the most debilitating disease and disorder increasing evidence suggest an urgent need for new therapeutic agents with lower toxicity and high efficacy. Some Thyme species extracts have remarkably been shown to positively affect depression and cancer cells. In the present study, we investigated the effect of Thymus kotschyanus on depression and cancer cells. To this end, in experiment 1, NMRI mice were treated orally with the ethanolic extract of T. kotschyanus (50, 150 and 250 mg/ml) for seven days and then depression-like behavior was measured by Forced Swim Test (FST) and Tail Suspension Test (TST)...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29319446/comparison-of-absorption-characteristics-of-oral-reference-and-compounded-itraconazole-formulations-in-healthy-cats
#11
Dianne I Mawby, Jacqueline C Whittemore, Leanne E Fowler, Mark G Papich
OBJECTIVE To compare absorption characteristics of orally administered compounded itraconazole capsules and suspension with those of reference (brand-name) formulations in healthy cats. DESIGN Randomized crossover study. ANIMALS 8 healthy adult cats. PROCEDURES After 12 hours of food withholding, cats received 50 mg of itraconazole (reference capsule, reference solution, compounded capsule, and compounded suspension) in a randomized crossover design, with a 21-day washout period. Capsules were administered with a small meal...
January 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29318993/a-case-of-severe-plasmodium-falciparum-malaria-co-infected-with-hiv-improved-with-exchange-transfusion
#12
Ayşe Sağmak Tartar, Ayhan Akbulut, Ömür Gökmen Sevindik, Hatice Handan Akbulut, Kutbeddin Demirdağ
In our country, within years, despite a dramatic drop in the number of patients with malaria, a dramatic increase in the number of patients with import malaria is noteworthy. A 32-year-old male patient presented with fever, shivering, malaise, and loss of appetite. He had travelled to West Africa. Laboratory findings were as follows: hemoglobin: 8.8 g/dL and anti-HIV: positive. Microscopic examinations of thin blood smears and thick blood preparations revealed widespread trophozoites. The presence of double-dotted ring forms and banana-shaped gametocytes resulted in Plasmodium falciparum malaria being diagnosed...
December 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29313261/enhancement-of-in-vivo-efficacy-and-oral-bioavailability-of-aripiprazole-with-solid-lipid-nanoparticles
#13
Silki, Vivek Ranjan Sinha
Aripiprazole (ARP), a second-generation or atypical antipsychotic, is poorly soluble and undergoes extensive hepatic metabolism and P-glycoprotein efflux which lead to reduced in vivo efficacy and increased dose-related side effects. To enhance in vivo efficacy and oral bioavailability of aripiprazole, aripiprazole-loaded solid lipid nanoparticles (SLNs) were developed using tristearin as solid lipid. Tween 80 and sodium taurocholate were used as surfactants to prepare SLNs using microemulsification method...
January 8, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29291438/synthesis-and-antidepressant-like-activity-of-novel-aralkyl-piperazine-derivatives-targeting-ssri-5-ht1a-5-ht7
#14
Zheng-Song Gu, Ai-Nan Zhou, Ying Xiao, Qing-Wei Zhang, Jian-Qi Li
A series of novel aralkyl piperazine derivatives were synthesized, and evaluated for their serotonin reuptake inhibitory and 5-HT1A/5-HT7 receptors affinities activity. Antidepressant activities in vivo of the compounds were screened using the forced swimming test (FST) and tail suspension test (TST). The results indicated that compounds 21k (RUI, IC50 = 31 nM; 5-HT1A, 5-HT7, ki = 62, 12 nM) and 21n (RUI, IC50 = 25 nM; 5-HT1A, 5-HT7, ki = 28, 3.3 nM) exhibited high affinities for the 5-HT1A/5-HT7 receptors coupled with potent serotonin reuptake inhibition...
December 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29286295/determination-of-tangeretin-in-rat-plasma-assessment-of-its-clearance-and-absolute-oral-bioavailability
#15
Mai Gamal Elhennawy, Hai-Shu Lin
Tangeretin (TAN) is a dietary polymethoxylated flavone that possesses a broad scope of pharmacological activities. A simple high-performance liquid chromatography (HPLC) method was developed and validated in this study to quantify TAN in plasma of Sprague-Dawley rats. The lower limit of quantification (LLOQ) was 15 ng/mL; the intra- and inter-day assay variations expressed in the form of relative standard deviation (RSD) were all less than 10%; and the assay accuracy was within 100 ± 15%. Subsequently, pharmacokinetic profiles of TAN were explored and established...
December 29, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/29279602/new-therapeutic-perceptions-in-a-patient-with-complicated-herpes-simplex-virus-1-keratitis-a-case-report-and-review-of-the-literature
#16
REVIEW
Dimitrios Kalogeropoulos, Aliki Geka, Konstantinos Malamos, Maria Kanari, Chris Kalogeropoulos
BACKGROUND Keratitis caused by herpes simplex virus (HSV) can have detrimental effects on the cornea leading to loss of vision. Modern therapies can contribute to the prevention of anatomical and functional damage. CASE REPORT An 80-year-old male with complicated HSV-1 keratitis of the left eye (confirmed diagnosis after microbiological investigation) presented three months after antiviral treatment with corneal blurring, severe epitheliopathy, thinning of the stroma, and neovascularization. At the time he was referred, the visual acuity of his left eye was very low, as he could only count fingers at a one-foot distance...
December 27, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29276267/limited-influence-of-excipients-in-extemporaneous-compounded-suspensions
#17
Eli Dijkers, Valerie Nanhekhan, Astrid Thorissen, Diego Marro, Marta Uriel
Objective: The objective of this study was to identify whether compounding oral suspensions with SyrSpend SF based on tablets or capsules is a suitable alternative for using raw pharmaceutical materials. Methods: Suspensions based on 5 different tablets and capsules were studied in SyrSpend SF. The summary of product characteristics of these different tablets and capsules were obtained from the manufacturer. Our hypothesis was that, if the maximum beyond-use date of the study was reached, the excipient did not seem to have an influence on the stability of the active pharmaceutical ingredient (API) within the studied time frame...
June 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/29275642/enhancement-of-dissolution-and-oral-bioavailability-of-lacidipine-via-pluronic-p123-f127-mixed-polymeric-micelles-formulation-optimization-using-central-composite-design-and-in-vivo-bioavailability-study
#18
Ahmed R Fares, Aliaa N ElMeshad, Mohamed A A Kassem
This study aims at preparing and optimizing lacidipine (LCDP) polymeric micelles using thin film hydration technique in order to overcome LCDP solubility-limited oral bioavailability. A two-factor three-level central composite face-centered design (CCFD) was employed to optimize the formulation variables to obtain LCDP polymeric micelles of high entrapment efficiency and small and uniform particle size (PS). Formulation variables were: Pluronic to drug ratio (A) and Pluronic P123 percentage (B). LCDP polymeric micelles were assessed for entrapment efficiency (EE%), PS and polydispersity index (PDI)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29274394/reduced-methicillin-resistant-staphylococcus-aureus-biofilm-formation-in-bone-cavities-by-photodynamic-therapy
#19
Thalita Santos Dantas Araújo, Paôlla Layanna Fernandes Rodrigues, Mariana Sousa Santos, Janeide Muritiba de Oliveira, Luciano Pereira Rosa, Vanderlei Salvador Bagnato, Kate Cristina Blanco, Francine Cristina da Silva
Photodynamic Therapy (PDT) is a promising alternative for the treatment of infectious bone lesions in the oral cavity. The objective of this study was to evaluate the antimicrobial effectiveness of PDT using blue LED associated with curcumin in methicillin-resistant Staphylococcus aureus biofilms (MRSA) in bovine bone cavities by fluorescence spectroscopy. Standardized suspensions of MRSA culture were inoculated into bone lesions to form biofilm. Forty bone species were distributed in three distinct groups: L-C- (control); L + C- (LED for 5 min...
December 20, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29273038/anti-stress-and-neuronal-cell-differentiation-induction-effects-of-rosmarinus-officinalis-l-essential-oil
#20
Myra O Villareal, Ayumi Ikeya, Kazunori Sasaki, Abdelkarim Ben Arfa, Mohamed Neffati, Hiroko Isoda
BACKGROUND: Mood disorder accounts for 13 % of global disease burden. And while therapeutic agents are available, usually orally administered, most have unwanted side effects, and thus making the inhalation of essential oils (EOs) an attractive alternative therapy. Rosmarinus officinalis EO (ROEO), Mediterranean ROEO reported to improve cognition, mood, and memory, the effect on stress of which has not yet been determined. Here, the anti-stress effect of ROEO on stress was evaluated in vivo and in vitro...
December 22, 2017: BMC Complementary and Alternative Medicine
keyword
keyword
81562
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"