keyword
MENU ▼
Read by QxMD icon Read
search

Oral liquid drug

keyword
https://www.readbyqxmd.com/read/28437488/the-novel-carboxylesterase-1-variant-c-662a-g-may-decrease-the-bioactivation-of-oseltamivir-in-humans
#1
Jaeseong Oh, SeungHwan Lee, Howard Lee, Joo-Youn Cho, Seo Hyun Yoon, In-Jin Jang, Kyung-Sang Yu, Kyoung Soo Lim
BACKGROUND: Human carboxylesterase 1 (CES1) is a serine esterase that hydrolyses various exogenous and endogenous compounds including oseltamivir, a prodrug used to treat influenza. A novel CES1 c.662A>G single nucleotide polymorphism (SNP) was predicted to decrease CES1 enzymatic activity in an in silico analysis. This study evaluated the effect of the c.662A>G SNP on the pharmacokinetics (PK) of oseltamivir in humans. METHODS: A single oral dose of oseltamivir at 75 mg was administered to 20 healthy subjects, 8 heterozygous c...
2017: PloS One
https://www.readbyqxmd.com/read/28421776/drugs-via-enteral-feeding-tubes-in-inpatients-dispersion-analysis-and-safe-use-of-dispensers
#2
Milena Pontes Portela Beserra, Cristiani Lopes Capistrano Gonçalves De Oliveira, Mileyde Ponte Portela, Marcos Venícios de Oliveira Lopes, Marta Maria de França Fonteles
OBJECTIVE: This study aimed to improve knowledge about drug administration through enteral feeding tubes (EFTs) in order to minimize efficacy and safety problems. MATERIAL AND METHODS: The study was performed in a public secondary care hospital with level II accreditation by the National Accreditation Organization (Organização Nacional de Acreditação ONA), in Fortaleza, Ceará, north-eastern Brazil. RESULTS: One hundred and eight oral solid medications that could be administered through EFTs and were not available in liquid forms were evaluated via transformation of their solid dosage forms into liquid forms...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28419964/effects-of-paeonia-emodi-on-hepatic-cytochrome-p450-cyp3a2-and-cyp2c11-expression-and-pharmacokinetics-of-carbamazepine-in-rats
#3
Mohammad Raish, Ajaz Ahmad, Khalid M Alkharfy, Basit L Jan, Kazi Mohsin, Abdul Ahad, Fahad I Al-Jenoobi, Abdullah M Al-Mohizea
Herbal medicines, dietary supplements, and other foods may pharmacokinetically and/or pharmacodynamically interact with carbamazepine (CBZ), which could lead to potential clinical consequences. Paeonia emodi (PE) is one of the herbs used as complementary therapy in the treatment of epileptic patients in some cultures, and may also be co-administered with CBZ. This study evaluates the effects of PE on the pharmacokinetics of CBZ and determines a possible mechanism of interaction. Rats were administered vehicle saline or PE (200mg/kg, p...
April 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28413326/effect-of-b-complex-vitamins-on-the-antifatigue-activity-and-bioavailability-of-ginsenoside-re-after-oral-administration
#4
Yin Bin Chen, Yu Fang Wang, Wei Hou, Ying Ping Wang, Sheng Yuan Xiao, Yang Yang Fu, Jia Wang, Si Wen Zheng, Pei He Zheng
BACKGROUND: Both ginsenoside Re and B-complex vitamins are widely used as nutritional supplements. They are often taken together so as to fully utilize their antifatigue and refreshing effects, respectively. Whether actually a drug-nutrient interaction exists between ginsenoside Re and B-complex vitamins is still unknown. The objective of this study was to simultaneously investigate the effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after their oral administration...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28412446/development-and-characterization-of-mucoadhesive-buccal-gels-containing-lipid-nanoparticles-of-ibuprofen
#5
Ana Camila Marques, Ana Isabel Rocha, Paula Leal, Marilene Estanqueiro, José Manuel Sousa Lobo
The lipid nanoparticles, namely Nanostructured Lipid Carriers (NLC), as drug delivery systems have been investigated for several years. One of the delivery routes for which these carriers can be applied is buccal administration. However, the liquid dispersions of lipid nanoparticles can be rapidly removed from oral cavity by saliva. Thus, the development of a system that allows increased retention time on the mucosa is necessary. For this reason, the development of mucoadhesive preparations for buccal administration of lipid nanoparticles becomes important...
April 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28406320/underestimated-impact-of-novel-psychoactive-substances-laboratory-confirmation-of-recreational-drug-toxicity-in-oslo-norway
#6
Odd Martin Vallersnes, Per Sverre Persett, Elisabeth Leere Øiestad, Ritva Karinen, Fridtjof Heyerdahl, Knut Erik Hovda
CONTEXT: Recreational drug toxicity is frequent. Availability of new psychoactive substances is steadily increasing. However, data with verified analyses from clinical settings are limited. To evaluate the impact of novel psychoactive substances (NPS) on recreational drug toxicity in Oslo, Norway, we analysed samples from a selection of patients. METHODS: All the patients presenting with recreational drug toxicity at the Oslo Accident and Emergency Outpatient Clinic (OAEOC) and at the Oslo University Hospital (OUH) were registered from April through September 2014...
April 13, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28400289/mathematical-modelling-of-liquid-transport-in-swelling-pharmaceutical-immediate-release-tablets
#7
Daniel Markl, Samy Yassin, D Ian Wilson, Daniel J Goodwin, Andrew Anderson, J Axel Zeitler
Oral dosage forms are an integral part of modern health care and account for the majority of drug delivery systems. Traditionally the analysis of the dissolution behaviour of a dosage form is used as the key parameter to assess the performance of a drug product. However, understanding the mechanisms of disintegration is of critical importance to improve the quality of drug delivery systems. The disintegration performance is primarily impacted by the hydration and subsequent swelling of the powder compact. Here we compare liquid ingress and swelling data obtained using terahertz pulsed imaging (TPI) to a set of mathematical models...
April 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28396527/leveraging-of-rifampicin-dosed-cynomolgus-monkeys-to-identify-bile-acid-3-o-sulfate-conjugates-as-potential-novel-biomarkers-for-organic-anion-transporting-polypeptides
#8
Rhishikesh Thakare, Hongying Gao, Rachel E Kosa, Yi-An Bi, Manthena V S Varma, Matthew Cerny, Raman Sharma, Max Kuhn, Bingshou Huang, Yiping Liu, Aijia Yu, Gregory S Walker, Mark Niosi, Larry M Tremaine, Yazen Alnouti, A David Rodrigues
In the search for novel bile acid (BA) biomarkers of liver organic anion-transporting polypeptides (OATPs), cynomolgus monkeys received oral rifampicin (RIF) at four dose levels (1, 3, 10 and 30 mg/kg) that generated plasma free Cmax values (0.06, 0.66, 2.57 and 7.79 μM, respectively) that covered the reported in vitro IC50s for OATP1B1 and OATP1B3 (≤ 1.7 μM). As expected, the area under the plasma concentration-time curve (AUC) of an OATP probe drug (intravenous (2)H4-pitavastatin, 0.2 mg/kg) was increased 1...
April 10, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28395991/simultaneous-determination-of-cocaine-crack-and-its-metabolites-in-oral-fluid-urine-and-plasma-by-liquid-chromatography-mass-spectrometry-and-its-application-in-drug-users
#9
Taís Regina Fiorentin, Felipe Bianchini D'Avila, Eloisa Comiran, Amanda Zamboni, Juliana Nichterwitz Scherer, Flavio Pechansky, Paulo Eduardo Mayorga Borges, Pedro Eduardo Fröehlich, Renata Pereira Limberger
INTRODUCTION: A single LC-MS equipment was used to validate three methods for simultaneously analyzing cocaine (COC), benzoylecgonine (BZE), cocaethylene (CE), anhydroecgonine methyl ester (AEME) and anhydroecgonine (AEC) in oral fluid (OF), urine and plasma. METHODS: The methods were carried out using a Kinetex HILIC column for polar compounds at 30°C. Mobile phase with isocratic condition of acetonitrile: 13mM ammonium acetate pH 6.0: methanol (55:35:10 v/v/v) at 0...
April 7, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28387740/protective-effect-of-bicyclol-on-anti-tuberculosis-drug-induced-liver-injury-in-rats
#10
Xin Liu, Manman Zhao, Jiaqi Mi, Hui Chen, Li Sheng, Yan Li
The present study was performed to investigate the effect of bicyclol, a synthetic anti-hepatitis drug with anti-oxidative and anti-inflammatory properties, on anti-tuberculosis (anti-TB) drug-induced liver injury and related mechanisms in rats. Bicyclol was given to rats by gavage 2 h before the oral administration of an anti-TB drug once a day for 30 days. Liver injury was evaluated by biochemical and histopathological examinations. Lipid peroxidation, mitochondrial function, and the activity of antioxidants were measured by spectrophotometric methods...
April 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28385011/pharmacokinetics-of-tilmicosin-in-healthy-pigs-and-in-pigs-experimentally-infected-with-haemophilus-parasuis
#11
Ling Zhang, Li Zhao, Yonghong Liu, Junfeng Liu, Xianqiang Li
A comparative in vivo pharmacokinetic (PK) study of tilmicosin (TIL) was conducted in 6 crossbred healthy pigs and 6 crossbred pigs infected with Haemophilus parasuis (H. parasuis) following oral administration of a single dose of 40 mg/kg. The infected model was established by intranasal inoculation and confirmed by clinical signs, blood biochemical and microscopic examination. TIL concentrations in plasma were determined by a validated high-performance liquid chromatography (HPLC) method with ultra violet detection at a wavelength of 285 nm and PK parameters were calculated by using the Winnonlin software...
April 6, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28377742/dysphagia-in-amyotrophic-lateral-sclerosis-impact-on-patient-behavior-diet-adaptation-and-riluzole-management
#12
Emanuela Onesti, Ilenia Schettino, Maria Cristina Gori, Vittorio Frasca, Marco Ceccanti, Chiara Cambieri, Giovanni Ruoppolo, Maurizio Inghilleri
This retrospective study aimed to investigate the clinical features associated with deteriorated swallow in amyotrophic lateral sclerosis (ALS) patients with spinal and bulbar onset, describe the modification of diet and liquid intake, and assess the impact of dysphagia on the use of riluzole. One hundred forty-five patients were observed periodically every 3-6 months. They underwent routinely fiberoptic endoscopic evaluation of swallowing (FEES) and spirometry; dysphagia severity was classified according to the Penetration Aspiration Scale and the Pooling score (P-score) integrated with other parameters such as sensation, collaboration, and age (P-SCA score)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28371693/pharmacokinetic-pharmacodynamic-modeling-of-benazepril-and-benazeprilat-after-administration-of-intravenous-and-oral-doses-of-benazepril-in-healthy-horses
#13
Juan Manuel Serrano-Rodríguez, Manuel Gómez-Díez, María Esgueva, Cristina Castejón-Riber, Antonio Mena-Bravo, Feliciano Priego-Capote, Nahúm Ayala, Juan Manuel Serrano Caballero, Ana Muñoz
Pharmacokinetic and pharmacodynamic (PK/PD) properties of the angiotensin-converting enzyme inhibitor (ACEI) benazeprilat have not been evaluated in horses. This study was designed to establish PK profiles for benazepril and benazeprilat after intravenous (IV) and oral (PO) administration of benazepril using a PK/PD model. This study also aims to determine the effects of benazeprilat on serum angiotensin converting enzyme (ACE), selecting the most appropriate dose that suppresses ACE activity. Six healthy horses in a crossover design received IV benazepril at 0...
March 28, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28371488/bioequivalence-study-of-warfarin-in-healthy-chinese-volunteers-with-a-validated-high-performance-liquid-chromatography-mass-spectrometry-method
#14
Wenlong Li, Fanlong Bu, Rong Li, Benjie Wang, Abdul Sami Shaikh, Yunyun Zhang, Ruichen Guo, Rui Zhang
This study was designed to investigate the pharmacokinetics of an innovative film-coated warfarin sodium tablet and to compare it with the marketed sugar-coated warfarin sodium tablet in humans. A single-dose, open-label, randomized, two-way crossover study was performed in 24 healthy Chinese male volunteers. They were administered 2.5 mg of innovative film-coated warfarin sodium tablets or the marketed sugar-coated warfarin sodium tablets. Blood samples were collected at different time points after dosing for investigation of the pharmacokinetics of warfarin in human plasma...
April 3, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28366653/preformulation-investigation-and-challenges-salt-formation-salt-disproportionation-and-hepatic-recirculation
#15
Kalle Sigfridsson, Lena Nilsson, Matti Ahlqvist, Thomas Andersson, Anna-Karin Granath
A compound, which is a selective peroxisome proliferator activated receptor (PPAR) agonist, was investigated. The aim of the presented studies was to evaluate the potential of the further development of the compound. Fundamental physicochemical properties and stability of the compound were characterized in solution by liquid chromatography and NMR and in solid-state by various techniques. The drug itself is a lipophilic acid with tendency to form aggregates in solution. The neutral form was only obtained in amorphous form with a glass-transition temperature of approximately 0°C...
March 31, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28353056/pharmacokinetics-of-escalating-doses-of-oral-psilocybin-in-healthy-adults
#16
Randall T Brown, Christopher R Nicholas, Nicholas V Cozzi, Michele C Gassman, Karen M Cooper, Daniel Muller, Chantelle D Thomas, Scott J Hetzel, Kelsey M Henriquez, Alexandra S Ribaudo, Paul R Hutson
INTRODUCTION: Psilocybin is a psychedelic tryptamine that has shown promise in recent clinical trials for the treatment of depression and substance use disorders. This open-label study of the pharmacokinetics of psilocybin was performed to describe the pharmacokinetics and safety profile of psilocybin in sequential, escalating oral doses of 0.3, 0.45, and 0.6 mg/kg in 12 healthy adults. METHODS: Eligible healthy adults received 6-8 h of preparatory counseling in anticipation of the first dose of psilocybin...
March 28, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28352156/fixed-dose-combination-orally-disintegrating-tablets-to-treat-cardiovascular-disease-formulation-in-vitro-characterization-and-physiologically-based-pharmacokinetic-modeling-to-assess-bioavailability
#17
Thomas J Dennison, Julian C Smith, Raj K Badhan, Afzal R Mohammed
Cardiovascular disease (CVD) is the leading cause of death among men and women worldwide. In CVD, hypertension and dyslipidemia commonly coexist and are managed through coadministration of amlodipine and atorvastatin, respectively. The case for fixed-dose combination (FDC) oral dosage forms and orally disintegrating tablet (ODT) technology to enhance outcomes and compliance is strong. This work follows the development and characterization of single and FDC ODTs containing amlodipine and atorvastatin, followed by bioequivalence comparison between these single and FDC formulations, using in vitro dissolution and Caco-2 apparent permeability (Papp) and in silico physiologically based pharmacokinetic modeling approaches...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28350806/pharmacokinetics-of-a-single-1g-dose-of-azithromycin-in-rectal-tissue-in-men
#18
Fabian Y S Kong, Thusitha W Rupasinghe, Julie A Simpson, Lenka A Vodstrcil, Christopher K Fairley, Malcolm J McConville, Jane S Hocking
Chlamydia is the most common bacterial sexually transmitted infection among men who have sex with men. Repeat infection following treatment with 1g azithromycin is common and treatment failure of up to 22% has been reported. This study measured the pharmacokinetics of azithromycin in rectal tissue in men following a single 1g dose to assess whether azithromycin reaches the rectal site in adequate concentrations to kill chlamydia. Ten healthy men took a single oral dose of 1g azithromycin and provided nine self-collected swabs and one blood sample over 14 days...
2017: PloS One
https://www.readbyqxmd.com/read/28346840/fabrication-and-evaluation-of-phytomenadione-as-a-nanostructure-lipid-carrier-for-enhancement-of-bioavailability
#19
Bader Mubarak Aljaeid, Khaled Mohamed Hosny
Owing to its limited aqueous solubility, Phytomenadione (vitamin K) undergoes a low bioavailability (50%) with a large inter-individual variability after oral administration. Therefore, the aim of this work was to incorporate vitamine K into nanostructure lipid carrier systems to improve its aqueous solubility and bioavailability. Phytomenadione was used as a liquid lipid, Precirol ATO5, and Compritol ATO were used as solid lipids, Labrasol and Cremophore EL as water soluble surfactants, Capryol 90 and Lauroglycol as lipid soluble surfactants...
March 27, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28342305/metabolic-profiling-of-nuciferine-in-rat-urine-plasma-bile-and-feces-after-oral-administration-using-ultra-high-performance-liquid-chromatography-diode-array-detection-quadrupole-time-of-flight-mass-spectrometry
#20
Xiao-Lei Wu, Ming-Jiang Wu, Xin-Ze Chen, Hao-Ling Ma, Li-Qin Ding, Feng Qiu, Qin Pan, De-Qin Zhang
Nuciferine, a major alkaloid found in Nelumbinis Folium, exhibits a broad spectrum of bioactivities, such as antiobesity, anti-diabetes and anti-inflammatory. However, many research regarding nuciferine focused on the extraction, isolation and biological activity, the metabolism is not comprehensively explained in vivo. Thence, the present of this paper is to establish a simple method for speculating metabolites of nuciferine. A total of 15 metabolites were detected and tentatively identified through ultra high performance liquid chromatography-diode array detection-quadrupole time-of-flight mass spectrometry (UHPLC-DAD-QTOF-MS), including 7 new metabolites...
June 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
keyword
keyword
81561
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"