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https://www.readbyqxmd.com/read/28235838/accuracy-of-enteral-syringes-with-commonly-prescribed-paediatric-liquid-medicines
#1
Sara Arenas-López, Karuna Gurung, Shane M Tibby, Miguel Ángel Calleja Hernández, Catherine Tuleu
OBJECTIVE: Oral syringes are the preferred method for delivering paediatric enteral drugs; however, little is known about factors affecting accuracy, particularly at volumes <5 mL. We investigated volumetric accuracy for enteral syringes, using commercially available liquid drug formulations with various physicochemical properties at clinically relevant volumes. DESIGN: In vitro experiment. INTERVENTIONS: Ten drugs were tested using two syringe brands (Baxa, Medicina) across a range of formulation volumes (0...
February 24, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28222659/antimalarial-solid-self-emulsifying-system-for-oral-use-in-vitro-investigation
#2
Sameer Bhandari, Vikas Rana, Ashok K Tiwary
AIM: The low aqueous solubility of artemether and lumefantrine makes them less bioavailable. It is expected that by formulating self-microemulsifying drug-delivery systems (SMEDDS), their aqueous solubility and absorption will thus be enhanced. Results & methodology: Optimized liquid SMEDDS containing artemether and lumefantrine was adsorbed on Neusilin US2(®) employing spray drying technique to convert it into solid SMEDDS. Almost 90% of both drugs were released within 15 min in their respective official dissolution media...
April 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28222334/a-quantification-method-for-determination-of-racemate-praziquantel-and-r-enantiomer-in-rat-plasma-for-comparison-of-their-pharmacokinetics
#3
Danlu Zhang, Haina Wang, Jianbo Ji, Lei Nie, Dequn Sun
Praziquantel is the drug of first choice for the control and treatment of all forms of schistosomiasis. Praziquantel is administered as a racemate, including R-enantiomer and S-enantiomer. Among them, R-enantiomer has main contribution to schistosomicidal activity. In this study, a sensitive and rapid liquid chromatography with tandem mass spectrometry was established and validated to determine the concentration of racemate praziquantel and R-enantiomer in rat plasma after oral administration. Chromatographic separation was performed on an Agilent Zorbax SB-C18 column...
February 14, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28216902/feeble-antipyretic-analgesic-and-anti-inflammatory-activities-were-found-with-regular-dose-4-o-%C3%AE-d-glucosyl-5-o-methylvisamminol-one-of-the-conventional-marker-compounds-for-quality-evaluation-of-radix-saposhnikoviae
#4
Jing-Ming Yang, Hua Jiang, Hong-Liang Dai, Zi-Wei Wang, Gui-Zhi Jia, Xiang-Cai Meng
INTRODUCTION: 4'-O-β-D-glucosyl-5-O-methylvisamminol (GML) is a conventional marker compound for quality control of Radix Saposhnikoviae. Despite that, neither pharmacodynamic or pharmacokinetic information is available with regard to GML. As such, the aim of thisstudy was to assess the conventional evaluation indices for the quality of Radix Saposhnikoviae. MATERIALS AND METHODS: Pyretic animal model, hot plate test, and ear edema model were established to evaluate and compare the antipyretic, analgesic, and anti-inflammatory effect of the chromone derivativescimifugin, prime-O-glucosylcimifugin (PGCN), and GML in Radix Saposhnikoviae...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28216465/increased-intestinal-permeation-and-modulation-of-presystemic-metabolism-of-resveratrol-formulated-into-self-emulsifying-drug-delivery-systems
#5
G Mamadou, C Charrueau, J Dairou, N Limas Nzouzi, B Eto, G Ponchel
Despite various beneficial biological properties, resveratrol lacks therapeutic applications because of poor bioavailability due to variable absorption and extensive metabolism. The present study aims at evaluating the capability of self-emulsifying drug delivery systems (SEDDS) to enhance resveratrol permeation across rat intestine and to modulate its presystemic metabolism. For that purpose, semi-solid (SS) and liquid (L) SEDDS were prepared and dispersed in an aqueous buffer to produce nanoemulsions (NE)...
February 17, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28214542/several-hpept1-transported-drugs-are-substrates-of-the-escherichia-coli-proton-coupled-oligopeptide-transporter-ydgr
#6
Bala K Prabhala, Nanda G Aduri, Mazhar Iqbal, Moazur Rahman, Michael Gajhede, Paul R Hansen, Osman Mirza
Proton-dependent oligopeptide transporters (POTs) are secondary active transporters found in all kingdoms of life. POTs utilize the proton electrochemical gradient for the uptake of nutrient dipeptides and tripeptides. The human POT hPepT1 is known to transport a number of drugs. As part of ongoing studies on substrate specificities of POTs from Escherichia coli, our aim in this study was to investigate whether bacterial POTs could also transport these drugs. For this, we selected the common orally administered drugs sulpiride, bestatin, valacyclovir, ampicillin and oseltamivir, that are all transported by hPepT1...
February 16, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28205294/simultaneous-determination-of-the-bioactive-components-in-rat-plasma-by-uplc-ms-ms-and-application-in-pharmacokinetic-studies-after-oral-administration-of-radix-scutellariae-extract
#7
Jin-Hua Tao, Jun Xu, Shu Jiang, Yong Ling, Dong-Geng Wang
A highly sensitive and rapid ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) has been developed and validated for simultaneous quantification of the four main bioactive compounds, i.e., baicalin, baicalein, wogonoside and wogonin in rat plasma after oral administration of Radix scutellariae extract. Clarithromycin was used as an internal standard (IS). Plasma samples were processed by protein precipitation with methanol. The separation was performed on an Acquity BEH C18 column (100 mm × 2...
February 16, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28205246/pharmacokinetics-of-valnemulin-after-intravenous-intramuscular-and-oral-administration-in-layer-chickens
#8
F Sun, R Fan, J Wang, L Xiong, J Shen, S Zhang, X Cao
The pharmacokinetic characteristics of valnemulin in layer chickens were studied after single intravenous, intramuscular, and oral administration at a dose of 15 mg/kg body weight. Plasma samples at certain time points were collected and the drug concentrations in them by ultra high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS). The concentration-time data for each individual were plotted by noncompartmental analysis for the whole three routes. Following intravenous administration, the plasma concentration showed tiny fluctuation...
February 15, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28203684/crushed-sublingual-versus-oral-ticagrelor-administration-strategies-in-patients-with-unstable-angina-a-pharmacokinetic-pharmacodynamic-study
#9
Piotr Niezgoda, Joanna Sikora, Malwina Barańska, Adam Sikora, Katarzyna Buszko, Emilia Siemińska, Michał Piotr Marszałł, Jolanta M Siller-Matula, Bernd Jilma, Dimitrios Alexopoulos, Tomasz Fabiszak, Jacek Kubica
Oral administration of crushed ticagrelor tablets turned out to be an efficacious method that improves its pharmacokinetics and pharmacodynamics. This strategy, however, is unlikely to eliminate the drug-drug interaction in patients receiving intravenous morphine, as the impairment of the P2Y12 inhibitor absorption related to decreased propulsive motility of the gastro-intestinal tract is the most likely mechanism of interaction. Thus, we designed a pharmacokinetic and pharmacodynamic study setting the feasibility of platelet inhibition with a loading dose of ticagrelor given as crushed tablets sublingually compared with two other ticagrelor loading dose administration strategies: integral tablet given orally and crushed tablet given orally in patients with unstable angina...
February 16, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28199409/effect-of-chinese-patent-medicine-si-mo-tang-oral-liquid-for-functional-dyspepsia-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#10
Yunxia Hu, Yu Bai, Zhiyun Hua, Jie Yang, Huahui Yang, Wenjun Chen, Junwei Xu, Zhiqiang Zhao
BACKGROUND: Si-Mo-Tang oral liquid (SMT) has been widely used to treat functional dyspepsia (FD), but the effectiveness is still controversial. A systematic review and meta-analysis of randomized controlled trials (RCTs) were performed to assess the efficacy and adverse effects of SMT for FD. METHODS: Investigators searched for articles with publication dates to June 21, 2016, from 9 English and Chinese electronic databases. Comparisons were SMT alone or SMT in combination with western medicine as experimental intervention, and western medicine or placebo as the control...
2017: PloS One
https://www.readbyqxmd.com/read/28196046/bioequivalence-of-a-new-oral-levosulpiride-formulation-compared-with-a-standard-one-in-healthy-volunteers
#11
Simona De Gregori, Laura Cipollina, Annalisa De Silvestri, Marianna Ventura, Roberta Michelini, Monica Morosini, Michela Montagna, Carmine Tinelli, Mario Regazzi, Mariadelfina Molinaro, Roberto Imberti
BACKGROUND: A monocentric, single-dose, open-label, two-way, crossover randomized study was conducted by the San Matteo Phase I Clinical Trial Unit and Experimental Therapy (Pavia, Italy) to assess the bioequivalence and the systemic tolerability of a new oral formulation of levosulpiride (tablet 25 mg: test) versus a commercially available formulation on the Italian market (tablet 25 mg: reference). METHODS: Thirty-five healthy adult volunteers, males (n = 19) and females (n = 16), aged between 18 and 55 years were screened and 32 of them were enrolled in the study...
February 11, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28194636/evaluation-of-the-utility-of-chimeric-mice-with-humanized-livers-for-the-characterization-and-profiling-of-the-metabolites-of-a-selective-inhibitor-ym543-of-the-sodium-glucose-cotransporter-2
#12
Naoyuki Nakada
PURPOSE: YM543 is a novel selective inhibitor of the sodium-glucose cotransporter 2. The objectives of the current study were to evaluate the utility of mice with humanized livers to predict human drug metabolites using YM543 as a case example. METHODS: Metabolites of YM543 generated in humans and experimental animals including chimeric mice with humanized liver, PXB mice, were analyzed via liquid chromatography-mass spectrometry, liquid chromatography-radiometric detector or nuclear magnetic resonance spectrometer...
February 13, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28192604/dapagliflozin-lowered-blood-glucose-reduces-respiratory-p-aeruginosa-infection-in-diabetic-mice
#13
Annika Åstrand, Cecilia Wingren, Audra Benjamin, John S Tregoning, James P Garnett, Helen Groves, Simren Gill, Maria Orogo-Wenn, Anders J Lundqvist, Dafydd Walters, David M Smith, John D Taylor, Emma H Baker, Deborah L Baines
BACKGROUND AND PURPOSE: Hyperglycaemia increases glucose concentrations in airway surface liquid (ASL) and increases the risk of pulmonary Pseudomonas aeruginosa infection. We determined whether reduction of blood and airway glucose concentrations by the anti-diabetic drug dapagliflozin could reduce P. aeruginosa growth/survival in the lungs of diabetic mice. EXPERIMENTAL APPROACH: The effect of dapagliflozin on blood and airway glucose concentration, the inflammatory response and infection were investigated in C57BL/6 J (wild type, WT) or db/db (leptin receptor-deficient) mice, treated orally with dapagliflozin prior to intranasal dosing with lipopolysaccharide (LPS) or inoculation with P...
February 13, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28187732/comparative-studies-on-the-multi-component-pharmacokinetics-of-aristolochiae-fructus-and-honey-fried-aristolochiae-fructus-extracts-after-oral-administration-in-rats
#14
COMPARATIVE STUDY
Jinbin Yuan, Gang Ren, Jian Liang, Chong-Zhi Wang, Zhihong Yan, Qun Huang, Jiankang Li, Yang Chen, Yi Tang, Xiaofei Liu, Chun-Su Yuan
BACKGROUND: Aristolochiae Fructus (AF) and honey-fried Aristolochiae Fructus (HAF) have been used in China for a long time as anti-tussive and expectorant drugs. Few clinical cases have been reported to be associated with the toxicity of AF and HAF, although relatively high amounts of aristolochic acids (AAs) have been found in them. Our previous experiments have verified from the chemical changes and from traditional toxicology that honey-processing can significantly reduce the toxicity of AF...
February 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28178908/oral-dosage-forms-and-drug-delivery-systems-tablets-oral-films-liquid-dosage-forms-oral-bioavailability-enhancement
#15
Raid Alany
No abstract text is available yet for this article.
March 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28178597/determination-of-topiramate-in-dried-blood-spots-using-single-quadrupole-gas-chromatography-mass-spectrometry-after-flash-methylation-with-trimethylanilinium-hydroxide
#16
Roberta Zilles Hahn, Marina Venzon Antunes, Priscila Costa Arnhold, Natalia Bordin Andriguetti, Simone Gasparin Verza, Rafael Linden
Dried blood spots (DBS) sampling obtained from fingerpricks is a promising and patient friendly alternative for obtaining samples for drug quantification, that could be of interest for topiramate (TOP) therapeutic drug monitoring. The aim of this study was to develop and validate a simple and fast GC-MS assay for TOP measurement in dried blood spots (DBS). The method uses a liquid extraction of one 8mm DBS, followed by a flash methylation with TMAH, and separation in a DB-5ms capillary column. Total analytical run time was 15min...
February 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28178590/the-pharmacokinetics-of-oral-ketoprofen-in-patients-after-gastric-resection
#17
Joanna Porażka, Agnieszka Karbownik, Dawid Murawa, Arkadiusz Spychała, Magdalena Firlej, Tomasz Grabowski, Paweł Murawa, Edmund Grześkowiak, Edyta Szałek
BACKGROUND: Total and partial gastric resection may affect the pharmacokinetics of drugs, especially orally administered a few days after surgery. Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) broadly used to treat postoperative pain, including patients after gastric resection. The aim of the research was to analyse the pharmacokinetics (PK) of orally administered ketoprofen in patients after gastrectomy. METHODS: The research was carried out on two groups of patients after total (TG; Roux-Y procedure) and partial (PG; Billroth II procedure) gastrectomy...
December 9, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28170419/determination-of-rivaroxaban-in-patient-s-plasma-samples-by-anti-xa-chromogenic-test-associated-to-high-performance-liquid-chromatography-tandem-mass-spectrometry-hplc-ms-ms
#18
Priscilla Bento Matos Derogis, Livia Rentas Sanches, Valdir Fernandes de Aranda, Marjorie Paris Colombini, Cristóvão Luis Pitangueira Mangueira, Marcelo Katz, Adriana Caschera Leme Faulhaber, Claudio Ernesto Albers Mendes, Carlos Eduardo Dos Santos Ferreira, Carolina Nunes França, João Carlos de Campos Guerra
Rivaroxaban is an oral direct factor Xa inhibitor, therapeutically indicated in the treatment of thromboembolic diseases. As other new oral anticoagulants, routine monitoring of rivaroxaban is not necessary, but important in some clinical circumstances. In our study a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was validated to measure rivaroxaban plasmatic concentration. Our method used a simple sample preparation, protein precipitation, and a fast chromatographic run...
2017: PloS One
https://www.readbyqxmd.com/read/28167558/pharmacokinetic-and-tissue-distribution-of-benznidazole-after-oral-administration-in-mice
#19
Luísa Perin, Rodrigo Moreira da Silva, Kátia da Silva Fonseca, Jamille Mirelle de Oliveira Cardoso, Fernando Augusto Siqueira Mathias, Levi Eduardo Soares Reis, Israel Molina, Rodrigo Correa-Oliveira, Paula Melo de Abreu Vieira, Cláudia Martins Carneiro
Specific chemotherapy using Benznidazole (BNZ) for Chagas disease during the chronic stage is controversial due to its limited efficacy and toxic effects. Although BNZ has been used to treat Chagas disease since the 1970s, few studies about the biodistribution of this drug exist. In this study, BNZ tissue biodistribution in a murine model and its pharmacokinetic profile in plasma were monitored. A bioanalytical high-performance liquid chromatography with an ultraviolet detector (HPLC-UV) method was developed and validated according to the European Medicines Agency for quantification of BNZ in organs and plasma samples prepared by liquid-liquid extraction using ethyl acetate...
February 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28167418/evaluation-of-in-silico-pharmacokinetic-properties-and-in-vitro-cytotoxic-activity-of-selected-newly-synthesized-n-succinimide-derivatives
#20
Natasa P Milosevic, Vesna Kojic, Jelena Curcic, Dimitar Jakimov, Natasa Milic, Nebojsa Banjac, Gordana Uscumlic, Roman Kaliszan
Design of a new drug entity is usually preceded by analysis of quantitative structure activity (properties) relationships, QSA(P)R. Six newly synthesized succinimide derivatives have been determined for (i) in silico physico-chemical descriptors, pharmacokinetic and toxicity predictors, (ii) in vitro biological activity on four different carcinoma cell lines and on normal fetal lung cells and (iii) lipophilicity on liquid chromatography. All compounds observed were predicted for good permeability and solubility, good oral absorption rate and moderate volume of distribution as well as for modest blood brain permeation, followed by acceptable observed toxicity...
January 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
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