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https://www.readbyqxmd.com/read/29775979/-the-open-retromuscular-preperitoneal-mesh-repair-of-the-incisional-lateral-hernia-technique-and-results-of-a-prospective-cohort-study
#1
Friedrich-Eckart Isemer, Ulrich Dietz, Maximilian Ackermann
INTRODUCTION: Surgical approaches to flank hernias have been poorly standardised. The most demanding issues in intermuscular net insertion are the limited area in the dorsal direction and the difficulties in fixing the net to the costal arch or the iliac crest. This is why many different surgical procedures have been published. PATIENTS/MATERIAL AND METHODS: From August 2015 to October 2016, nine patients with a primary incisional lateral hernia received open retromuscular preperitoneal mesh repair...
May 18, 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29774726/single-lung-ventilation-associated-to-ecmo-an-alternative-approach-to-manage-ventilator-induced-lung-injuries-in-infants
#2
Matteo Di Nardo, Joseph Nunziata, Francesca Stoppa, Margherita Lonero, Daniela Perrotta, Corrado Cecchetti, Salvatore Grasso
No abstract text is available yet for this article.
May 15, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29726304/retrorectus-repair-of-incisional-ventral-hernia-with-urinary-bladder-matrix-reinforcement-in-a-long-term-porcine-model
#3
D Adam Young, Nicolette Jackson, Catherine A Ronaghan, Collin Em Brathwaite, Thomas W Gilbert
AIM: Not all biologically derived materials elicit the same host response when used for reinforcement of ventral hernia repairs. This study aimed to evaluate the remodeling characteristics of the abdominal wall following reinforcement with urinary bladder matrix (UBM) in a large animal preclinical model of ventral hernia repair. MATERIALS & METHODS: Midline defects in 36 Yucatan minipigs were reinforced with UBM-derived surgical devices using a classic Rives-Stoppa-Wantz approach, and compared with primary repair controls...
May 4, 2018: Regenerative Medicine
https://www.readbyqxmd.com/read/29707112/full-in-frame-exon-3-skipping-of-brca2-confers-high-risk-of-breast-and-or-ovarian-cancer
#4
Sandrine M Caputo, Mélanie Léone, Francesca Damiola, Asa Ehlen, Aura Carreira, Pascaline Gaidrat, Alexandra Martins, Rita D Brandão, Ana Peixoto, Ana Vega, Claude Houdayer, Capucine Delnatte, Myriam Bronner, Danièle Muller, Laurent Castera, Marine Guillaud-Bataille, Inge Søkilde, Nancy Uhrhammer, Sophie Demontety, Hélène Tubeuf, Gaïa Castelain, Uffe Birk Jensen, Ambre Petitalot, Sophie Krieger, Cédrick Lefol, Virginie Moncoutier, Nadia Boutry-Kryza, Henriette Roed Nielsen, Olga Sinilnikova, Dominique Stoppa-Lyonnet, Amanda B Spurdle, Manuel R Teixeira, Florence Coulet, Mads Thomassen, Etienne Rouleau
Germline pathogenic variants in the BRCA2 gene are associated with a cumulative high risk of breast/ovarian cancer. Several BRCA2 variants result in complete loss of the exon-3 at the transcript level. The pathogenicity of these variants and the functional impact of loss of exon 3 have yet to be established. As a collaboration of the COVAR clinical trial group (France), and the ENIGMA consortium for investigating breast cancer gene variants, this study evaluated 8 BRCA2 variants resulting in complete deletion of exon 3...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29665859/morphology-and-genomic-hallmarks-of-breast-tumours-developed-by-atm-deleterious-variant-carriers
#5
Anne-Laure Renault, Noura Mebirouk, Laetitia Fuhrmann, Guillaume Bataillon, Eve Cavaciuti, Dorothée Le Gal, Elodie Girard, Tatiana Popova, Philippe La Rosa, Juana Beauvallet, Séverine Eon-Marchais, Marie-Gabrielle Dondon, Catherine Dubois d'Enghien, Anthony Laugé, Walid Chemlali, Virginie Raynal, Martine Labbé, Ivan Bièche, Sylvain Baulande, Jacques-Olivier Bay, Pascaline Berthet, Olivier Caron, Bruno Buecher, Laurence Faivre, Marc Fresnay, Marion Gauthier-Villars, Paul Gesta, Nicolas Janin, Sophie Lejeune, Christine Maugard, Sébastien Moutton, Laurence Venat-Bouvet, Hélène Zattara, Jean-Pierre Fricker, Laurence Gladieff, Isabelle Coupier, Georgia Chenevix-Trench, Janet Hall, Anne Vincent-Salomon, Dominique Stoppa-Lyonnet, Nadine Andrieu, Fabienne Lesueur
BACKGROUND: The ataxia telangiectasia mutated (ATM) gene is a moderate-risk breast cancer susceptibility gene; germline loss-of-function variants are found in up to 3% of hereditary breast and ovarian cancer (HBOC) families who undergo genetic testing. So far, no clear histopathological and molecular features of breast tumours occurring in ATM deleterious variant carriers have been described, but identification of an ATM-associated tumour signature may help in patient management. METHODS: To characterise hallmarks of ATM-associated tumours, we performed systematic pathology review of tumours from 21 participants from ataxia-telangiectasia families and 18 participants from HBOC families, as well as copy number profiling on a subset of 23 tumours...
April 17, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29609970/modified-stoppa-approach-for-operative-treatment-of-acetabular-fractures-10-year-experience-and-mid-term-follow-up
#6
Diederik O Verbeek, Kornelis J Ponsen, Mark van Heijl, J Carel Goslings
INTRODUCTION: The (modified) Stoppa approach for acetabular fracture surgery has gained significant popularity and early results have been encouraging but clinical outcome at extensive follow-up is scarce. The purpose of this study is to provide an update on our experience with this approach for operative treatment of acetabular fractures and to assess clinical outcome at mid-term follow-up. METHODS: In this retrospective study, all patients treated operatively for an acetabular fracture using the Stoppa approach over a 10-year period were included...
March 27, 2018: Injury
https://www.readbyqxmd.com/read/29568098/association-between-response-kinetics-and-outcomes-in-relapsed-refractory-multiple-myeloma-analysis-from-tourmaline-mm1
#7
Laurent Garderet, Jacob P Laubach, Anne-Marie Stoppa, Parameswaran Hari, Michele Cavo, Heinz Ludwig, María-Victoria Mateos, Katarina Luptakova, Jianchang Lin, Godwin Yung, Helgi van de Velde, Deborah Berg, Philippe Moreau, Paul G Richardson
No abstract text is available yet for this article.
March 12, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29559061/outcomes-after-ventral-hernia-repair-using-the-rives-stoppa-endoscopic-and-open-component-separation-techniques
#8
Thomas O Muse, Brittany A Zwischenberger, M Troy Miller, Daniel A Borman, Daniel L Davenport, J Scott Roth
Complex ventral hernias remain a challenge for general surgeons despite advances in minimally invasive surgical techniques. This study compares outcomes following Rives-Stoppa (RS) repair, components separation technique with mesh (CST-M) or without mesh (CST), and endoscopic components separation technique (ECST). A retrospective review of patients undergoing open ventral hernia repair between 2006 and 2011 was performed. Analysis included patient demographics, surgical site occurrences, hernia recurrence, hospital readmission, and mortality...
March 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29536110/easy-endoscopic-approach-to-the-symphysis-a-new-minimally-invasive-approach-for-the-plate-osteosynthesis-of-the-symphysis-and-the-anterior-pelvic-ring-a-cadaver-study-and-first-clinical-results
#9
Markus Alexander Küper, Alexander Trulson, Inga Maria Trulson, Christian Minarski, Leonard Grünwald, Christoph Gonser, Christian Bahrs, Bernhard Hirt, Ulrich Stöckle, Fabian Maria Stuby
BACKGROUND: Minimally invasive surgical approaches to reduce approach-associated morbidity are an interdisciplinary goal in surgery. In principle, the endoscopic approach for the extraperitoneal repair of groin hernias is the minimally invasive variant of the modified Stoppa-approach, which is used for the treatment of pelvic ring injuries in traumatology. METHOD: Anatomical feasibility study regarding the plate osteosynthesis of the anterior pelvic ring via a minimally invasive variant of the modified Stoppa-approach...
March 13, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29534413/-operative-treatment-of-delayed-acetabular-fractures-through-combined-anterior-and-kocher-langenbeck-approaches
#10
C Deng, W D Ni, S Q Guo, G Luo, W Shui, B Qiao
Objective: To discuss the clinical outcomes of treating delayed acetabular fractures by combined anterior and posterior approach. Methods: A retrospective analysis was conducted of 31 delayed acetabular fractures from February 2012 to February 2017 in the First Affiliated Hospital of Chongqing Medical University, including 18 males and 13 females with age of 48.5 years(23 to 67 years) .The injury to the operation time was 35.9 days(22 to 183 days). Of these 31 cases, there were 6 cases of transverse and posterior wall fracture, 8 cases with anterior column+ posterior half transverse fracture, 12 cases with double column fracture and 5 cases of "T" type fracture according to Letournel-Judet classification...
March 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29523884/extending-autologous-transplantation-as-first-line-therapy-in-multiple-myeloma-patients-with-severe-renal-impairment-a-retrospective-study-by-the-sfgm-tc
#11
Karine Augeul-Meunier, Marie-Lorraine Chretien, Anne-Marie Stoppa, Lionel Karlin, Lofti Benboubker, Jose Miguel Torregrosa Diaz, Mohamad Mohty, Ibrahim Yakoub-Agha, Jacques-Olivier Bay, Aurore Perrot, Claude-Eric Bulabois, Anne Huynh, Mélanie Mercier, Laurent Frenzel, Hervé Avet-Loiseau, Régis Peffault de Latour, Jérôme Cornillon
Renal impairment is a common complication of multiple myeloma (MM), accounting for 20-30% of MM patients at diagnosis and 40-50% of patients during the course of their disease. This feature is associated with poor prognosis and shorter survival as compared to patients with normal renal function (NRF). Therefore, therapeutic management is challenging as autologous stem cell transplantation (ASCT) is often not considered as a valuable strategy, mainly due to concerns of toxicity. In this retrospective and multicenter study, we included 55 MM patients with dialysis-dependent or independent renal failure who underwent high-dose melphalan-based ASCT in order to assess the efficacy outcomes and toxicities of this strategy...
March 9, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29519260/-inguinal-hernia-repair-bringing-order-to-variety
#12
C V van Hessen, J P J Burgmans, E J M M Verleisdonk
- With around 30,000 interventions a year, correction of an inguinal hernia is one of the most commonly performed surgeries in the Netherlands. One would therefore expect the same technique to be used all over the world by now. There are nevertheless different procedures, depending on a patient's age and history, the type of inguinal hernia and the expertise of the surgeon.- When the pathophysiology of an inguinal hernia became clear at the end of the 19th century, Bassini laid the foundation of modern inguinal hernia surgery: reinforcing the posterior wall of the inguinal canal after repositioning the hernial sac with its contents...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29508368/clinicians-use-of-breast-cancer-risk-assessment-tools-according-to-their-perceived-importance-of-breast-cancer-risk-factors-an-international-survey
#13
Anne Brédart, Jean-Luc Kop, Antonis C Antoniou, Alex P Cunningham, Antoine De Pauw, Marc Tischkowitz, Hans Ehrencrona, Marjanka K Schmidt, Sylvie Dolbeault, Kerstin Rhiem, Douglas F Easton, Peter Devilee, Dominique Stoppa-Lyonnet, Rita Schmutlzer
The BOADICEA breast cancer (BC) risk assessment model and its associated Web Application v3 (BWA) tool are being extended to incorporate additional genetic and non-genetic BC risk factors. From an online survey through the BOADICEA website and UK, Dutch, French and Swedish national genetic societies, we explored the relationships between the usage frequencies of the BWA and six other common BC risk assessment tools and respondents' perceived importance of BC risk factors. Respondents (N = 443) varied in age, country and clinical seniority but comprised mainly genetics health professionals (82%) and BWA users (93%)...
March 5, 2018: Journal of Community Genetics
https://www.readbyqxmd.com/read/29469200/mutiple-dicer1-related-lesions-associated-with-a-germline-deep-intronic-mutation
#14
Florian Verrier, Catherine Dubois d'Enghien, Marion Gauthier-Villars, Valérie Bonadona, Cécile Faure-Conter, Frédérique Dijoud, Dominique Stoppa-Lyonnet, Claude Houdayer, Lisa Golmard
Germline DICER1 pathogenic variants predispose to numerous benign and malignant tumors. In this report, we describe DICER1 gene analysis in an adolescent diagnosed with multinodular goiter, ovarian Sertoli-Leydig cell tumor, and lung cyst. DICER1 mutational screening at the DNA level failed to detect any pathogenic variant. Subsequent messenger RNA (mRNA) analysis revealed a 132 nucleotide intronic sequence exonization. This truncating event was caused by a deep intronic mutation generating a de novo acceptor splice site...
June 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29450631/preoperative-combination-of-progressive-pneumoperitoneum-and-botulinum-toxin-type-a-in-patients-with-loss-of-domain-hernia
#15
José Bueno-Lledó, Antonio Torregrosa, Raquel Jiménez, Providencia García Pastor
INTRODUCTION: Preoperative progressive pneumoperitoneum (PPP) and botulinum toxin type A (BT) are tools in the surgical preparation of patients with loss of domain hernias (LODH). The aim of this paper is to report our experience with these preoperative techniques in 70 patients with LODH. METHODS: Observational study of 70 consecutive patients with LODH was conducted between May 2010 and May 2016. Diameters of the hernia sac, incisional hernia (VIH), and abdominal cavity (VAC) volumes, and VIH/VAC ratio were measured before and after PPP and BT, using abdominal CT scan data...
February 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29439543/patient-centered-care-in-breast-cancer-genetic-clinics
#16
Anne Brédart, Amélie Anota, Julia Dick, Violetta Kuboth, Olivier Lareyre, Antoine De Pauw, Alejandra Cano, Dominique Stoppa-Lyonnet, Rita Schmutzler, Sylvie Dolbeault, Jean-Luc Kop
With advances in breast cancer (BC) gene panel testing, risk counseling has become increasingly complex, potentially leading to unmet psychosocial needs. We assessed psychosocial needs and correlates in women initiating testing for high genetic BC risk in clinics in France and Germany, and compared these results with data from a literature review. Among the 442 counselees consecutively approached, 212 (83%) in France and 180 (97%) in Germany, mostly BC patients (81% and 92%, respectively), returned the 'Psychosocial Assessment in Hereditary Cancer' questionnaire...
February 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29419433/impact-of-extramedullary-disease-in-patients-with-newly-diagnosed-multiple-myeloma-undergoing-autologous-stem-cell-transplantation-a-study-from-the-chronic-malignancies-working-party-of-the-ebmt
#17
Nico Gagelmann, Diderik-Jan Eikema, Simona Iacobelli, Linda Koster, Hareth Nahi, Anne-Marie Stoppa, Tamás Masszi, Denis Caillot, Stig Lenhoff, Miklos Udvardy, Charles Crawley, William Arcese, Clara Mariette, Ann Hunter, Xavier Leleu, Martin Schipperus, Michel Delforge, Pietro Pioltelli, John A Snowden, Maija Itälä-Remes, Maurizio Musso, Anja van Biezen, Laurent Garderet, Nicolaus Kröger
We investigated extramedullary disease in newly diagnosed multiple myeloma patients and its impact on outcome following first-line autologous stem cell transplantation. We identified 3744 adult myeloma patients who received up-front single (n=3391) or tandem transplantation (n=353) between 2005 and 2014 with available data on extramedullary involvement at diagnosis. The overall incidence of extramedullary disease was 18.2% (n=682) and increased per year from 6.5% (2005) to 23.7% (2014). Paraskeletal involvement was found in 543 (14...
May 2018: Haematologica
https://www.readbyqxmd.com/read/29330561/salvage-therapy-post-pomalidomide-based-regimen-in-relapsed-refractory-myeloma
#18
Guillemette Fouquet, Lionel Karlin, Margaret Macro, Denis Caillot, Murielle Roussel, Bertrand Arnulf, Brigitte Pegourie, Marie Odile Petillon, Claire Mathiot, Cyrille Hulin, Brigitte Kolb, Anne-Marie Stoppa, Sabine Brechiniac, Philippe Rodon, Mamoun Dib, Mourad Tiab, Valentine Richez, Carla Araujo, Marc Wetterwald, Laurent Garderet, Bruno Royer, Aurore Perrot, Lotfi Benboubker, Olivier Decaux, Martine Escoffre-Barbe, Jean Paul Fermand, Philippe Moreau, Hervé Avet-Loiseau, Michel Attal, Thierry Facon, Xavier Leleu
The combination of pomalidomide and low-dose dexamethasone (Pom-Dex) has proved effective and safe in patients with end-stage relapsed/refractory multiple myeloma (RRMM), otherwise characterized by a very poor outcome. MM remains an incurable disease with unavoidable relapses, and the outcome after pomalidomide is still dismal. However, some patients demonstrate prolonged survival even beyond pomalidomide therapy.We sought to analyze the treatment of RRMM patients following Pom-Dex therapy and the response and survival after this next treatment line...
May 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29279241/mri-evaluation-of-sacral-chordoma-treated-with-carbon-ion-radiotherapy-alone
#19
Lorenzo Preda, Davide Stoppa, Maria Rosaria Fiore, Giulia Fontana, Sofia Camisa, Roberto Sacchi, Michele Ghitti, Gisela Viselner, Piero Fossati, Francesca Valvo, Viviana Vitolo, Maria Bonora, Alberto Iannalfi, Barbara Vischioni, Alessandro Vai, Edoardo Mastella, Guido Baroni, Roberto Orecchia
BACKGROUND AND PURPOSE: To compare RECIST 1.1 with volume modifications in patients with sacral chordoma not suitable for surgery treated with carbon ions radiotherapy (CIRT) alone. To evaluate patients pain before and after CIRT. To detect if baseline Apparent Diffusion Coefficient values (ADC) from Diffusion Weighted sequences could predict response to treatment. MATERIAL AND METHODS: Patients included had one cycle of CIRT and underwent MRI before and after treatment...
December 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29242790/surgical-retrieval-of-an-impaled-tapestry-needle-from-the-true-pelvic-cavity-of-a-child-an-unusual-case-report
#20
Nirmal Raj Gopinathan, Rakesh John, Himanshu Kanwat, Pebam Sudesh
Introduction: Impalement injuries of pelvis have been reported in children but are uncommon. Impalement could be associated with injuries to deep organs, wound contamination, crush injuries, and in certain instances, can even be fatal. Case Report: We present a bizarre case of a 2-year-old female child who presented to us with a tapestry needle embedded in the true pelvic cavity after a history of fall on the buttock while playing at home. The impaled needle was eventually successfully extracted surgically using the modified Stoppa's approach and the post-operative period was uneventful...
September 2017: Journal of Orthopaedic Case Reports
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