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https://www.readbyqxmd.com/read/28065687/restless-legs-syndrome-and-cardiovascular-disease-a-research-roadmap
#1
REVIEW
Daniel J Gottlieb, Virend K Somers, Naresh M Punjabi, John W Winkelman
In this paper, we first critically appraise the epidemiologic literature examining the association of restless legs syndrome (RLS) with cardiovascular disease (CVD) and then consider whether lessons learned from the study of cardiovascular consequences of other sleep disorders might inform a research agenda to examine the potential mechanisms of cardiovascular morbidity of RLS. Cross-sectional and longitudinal studies are both mixed as to whether there is a meaningful association of RLS and CVD. On the other hand, numerous cross-sectional and longitudinal observational studies have shown a strong association of obstructive sleep apnea (OSA) with CVD risk...
October 27, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28065402/genetics-of-restless-legs-syndrome
#2
Juliane Winkelmann, Barbara Schormair, Lan Xiong, Patrick A Dion, David B Rye, Guy A Rouleau
At the outset of genetic studies in restless legs syndrome (RLS), the disorder was assumed to be a classical monogenic disorder that runs in families. However, years of family studies did not reveal any causally-related genes or genetic variants. The advent of high-throughput genotyping technology led to a change; genome-wide association studies in large case-control samples became feasible, which led to the identification of first genetic risk variants for RLS. Variants detected by this approach are common ones, which that individually confer only a minor increase in risk of disease...
November 12, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28010837/raptor-acupuncture-for-treating-chronic-degenerative-joint-disease
#3
Keum Hwa Choi, Gail Buhl, Julia Ponder
A permanently captive 21-year-old male bald eagle was diagnosed with chronic degenerative joint disease in the right stifle with severe lameness (Grade 5) based on radiography. Clinical signs included decreased movement, vocalization, non weight-bearing on the affected limb, inappetence, depression, and pododermatitis on the left foot (bumblefoot, Grade 3). The eagle was treated with anti-inflammatory or analgesic drugs including carprofen and celecoxib. As there was no observed clinical improvement with any of the treatments, acupuncture treatment was provided...
December 2016: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28004950/stimulation-of-5-ht2a-receptors-recovers-sensory-responsiveness-in-acute-spinal-neonatal-rats
#4
Hillary E Swann, Sierra D Kauer, Jacob T Allmond, Michele R Brumley
Quipazine is a 5-HT2A-receptor agonist that has been used to induce motor activity and promote recovery of function after spinal cord injury in neonatal and adult rodents. Sensory stimulation also activates sensory and motor circuits and promotes recovery after spinal cord injury. In rats, tail pinching is an effective and robust method of sacrocaudal sensory afferent stimulation that induces motor activity, including alternating stepping. In this study, responsiveness to a tail pinch following treatment with quipazine (or saline vehicle control) was examined in spinal cord transected (at midthoracic level) and intact neonatal rats...
December 22, 2016: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28004392/a-critical-period-of-corticomuscular-and-emg-emg-coherence-detection-in-9-25-week-old-healthy-infants
#5
Anina Ritterband-Rosenbaum, Anna Herskind, Xi Li, Maria Willerslev-Olsen, Mikkel Damgaard Olsen, Simon Francis Farmer, Jens Bo Nielsen
The early postnatal development of functional corticospinal connections in human infants is not fully clarified. We used EEG and EMG to investigate the development of corticomuscular and intramuscular coherence as indicators of functional corticospinal connectivity in healthy infants aged 1-66 weeks. EEG was recorded over leg and hand area of motor cortex. EMG recordings were made from right ankle dorsiflexor and right wrist extensor muscles. Quantification of the amount of corticomuscular coherence in the 20-40 Hz frequency band showed a significantly larger coherence for infants aged 9-25 weeks compared to younger and older infants...
December 22, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/28002679/ocrelizumab-versus-interferon-beta-1a-in-relapsing-multiple-sclerosis
#6
Stephen L Hauser, Amit Bar-Or, Giancarlo Comi, Gavin Giovannoni, Hans-Peter Hartung, Bernhard Hemmer, Fred Lublin, Xavier Montalban, Kottil W Rammohan, Krzysztof Selmaj, Anthony Traboulsee, Jerry S Wolinsky, Douglas L Arnold, Gaelle Klingelschmitt, Donna Masterman, Paulo Fontoura, Shibeshih Belachew, Peter Chin, Nicole Mairon, Hideki Garren, Ludwig Kappos
Background B cells influence the pathogenesis of multiple sclerosis. Ocrelizumab is a humanized monoclonal antibody that selectively depletes CD20+ B cells. Methods In two identical phase 3 trials, we randomly assigned 821 and 835 patients with relapsing multiple sclerosis to receive intravenous ocrelizumab at a dose of 600 mg every 24 weeks or subcutaneous interferon beta-1a at a dose of 44 μg three times weekly for 96 weeks. The primary end point was the annualized relapse rate. Results The annualized relapse rate was lower with ocrelizumab than with interferon beta-1a in trial 1 (0...
December 21, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27997256/ultrasound-functional-evaluation-of-fetuses-with-myelomeningocele-study-of-the-interpretation-of-results
#7
A Maroto, T Illescas, M Meléndez, S Arévalo, C Rodó, J L Peiró, M Belfort, A Cuxart, E Carreras
OBJECTIVE: To assess the reliability of the interpretation of a new technique for the ultrasound evaluation of the level of neurological lesion in fetuses with myelomeningocele. METHODS: Observational study including myelomeningocele fetuses, referred to our center for the sonographic assessment of the fetal lower-limb movements, made and recorded by an expert in Maternal-fetal medicine and a specialist in Rehabilitation. Two observers, with different levels of expertise and blinded to each other's results, interpreted each recorded scan two different times...
December 20, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27990668/femoral-head-ostectomy-for-the-treatment-of-acetabular-fracture-and-coxofemoral-joint-luxation-in-a-potbelly-pig
#8
Joe S Smith, Munashe Chigerwe, Carly Kanipe, Sarah Gray
OBJECTIVE: To report the successful surgical treatment of a comminuted left acetabular fracture, a dorsally luxated left femoral head, and avulsion of the ligament of the femoral head by femoral head ostectomy (FHO) and physical therapy in a companion Potbelly pig. STUDY DESIGN: Case report. ANIMALS: A 1-year-old, 13 kg, castrated male, companion Potbelly pig. METHODS: The pig presented with a nonweight bearing left pelvic limb lameness of 3 weeks' duration that was noticed shortly after the pig got caught under a fence...
December 19, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27987045/continuous-fetal-head-flexion-as-a-marker-for-prenatal-diagnosis-of-lethal-multiple-pterygium-syndrome-a-case-report
#9
Akihiro Hasegawa, Mieko Hanaoka, Takeshi Murakoshi
Lethal multiple pterygium syndrome (LMPS) is a fatal hereditary disease associated with abnormalities such as pterygium-induced congenital contractures. Fetal hydrops is present in more than half of all patients with LMPS, and all patients with LMPS are either stillborn or die in the early neonatal period. Ultrasonography findings for the prenatal diagnosis of LMPS include the detection of cutaneous webbing at multiple joints, multiple joint contractures, absent limb movement, and increased nuchal translucency...
December 16, 2016: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27940321/monitoring-infants-by-automatic-video-processing-a-unified-approach-to-motion-analysis
#10
Luca Cattani, Davide Alinovi, Gianluigi Ferrari, Riccardo Raheli, Elena Pavlidis, Carlotta Spagnoli, Francesco Pisani
A unified approach to contact-less and low-cost video processing for automatic detection of neonatal diseases characterized by specific movement patterns is presented. This disease category includes neonatal clonic seizures and apneas. Both disorders are characterized by the presence or absence, respectively, of periodic movements of parts of the body-e.g., the limbs in case of clonic seizures and the chest/abdomen in case of apneas. Therefore, one can analyze the data obtained from multiple video sensors placed around a patient, extracting relevant motion signals and estimating, using the Maximum Likelihood (ML) criterion, their possible periodicity...
December 1, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27939173/proposing-a-new-index-to-quantify-instantaneous-symmetry-during-manual-wheelchair-propulsion
#11
Félix Chénier, Julien Malbequi, Dany H Gagnon
Propelling a manual wheelchair (MWC) is a strenuous task that causes upper limb musculoskeletal disorders (MSD) in a large proportion of MWC users. Although most studies on MWC propulsion biomechanics assume that MWC propulsion is a relatively symmetric task, recent literature suggests that this is the case only when the assessed outcome measures are averaged over long periods of time, and not over short periods (i.e., instantaneously). No method is currently available to assess instantaneous symmetry. In this work, we present the Instantaneous Symmetry Index (ISI), a new method that quantifies how a variable has been instantaneously asymmetric during a selected time period...
January 25, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/27924251/free-vascularized-fibular-graft-transfer-in-the-reconstruction-of-defects-for-premalignant-and-malignant-musculoskeletal-conditions-of-the-femur-in-a-tertiary-care-setting-in-pakistan-a-series-of-six-cases
#12
Avais Raja, Hana Manzoor, Imad-Ud-Din Saqib, Waqar Jan, Mamoon Rashid
OBJECTIVE: To determine the application, success and complications of the utilization of free vascularized fibular grafts (FVFG) in the reconstruction of lower limb defects after resection of primary lower limb musculoskeletal tumors. METHODOLOGY: This descriptive retrospective case series analysis was conducted at Shifa International Hospital from January 2011 to January 2016. It included patients who had premalignant and malignant conditions of the lower limb and subsequently had the lesion resected followed by FVFG surgery...
November 4, 2016: Curēus
https://www.readbyqxmd.com/read/27923426/periodic-limb-movements-during-sleep-mimicking-rem-sleep-behavior-disorder
#13
Carles Gaig, Alex Iranzo, Montserrat Pujo, Hernando Perez, Joan Santamaria
STUDY OBJECTIVE: To describe a group of patients referredbecause of abnormal sleep behaviors that were suggestive ofREM sleep behavior disorder (RBD) in whom videopolysomnographyruled out RBD and showed the reportedbehaviors associated with vigorous periodic limb movementsduring sleep (PLMS). METHODS: Clinical history and video-polysomnography reviewof patients identified during routine visits in a sleepcenter. RESULTS: Patients were fifteen men and two women with a median age of 66 (range 48-77) years...
November 28, 2016: Sleep
https://www.readbyqxmd.com/read/27908587/higher-nocturnal-systolic-blood-pressure-in-patients-with-restless-legs-syndrome-compared-with-patients-with-insomnia
#14
Mariusz Sieminski, Kamil Chwojnicki, Markku Partinenen
BACKGROUND: There is evidence linking restless legs syndrome (RLS) with increased blood pressure (BP), but the mechanism of this relation remains unclear. Is the BP increased due to some features of RLS or to deterioration of sleep caused by RLS? This study compared values of nocturnal BP in patients with RLS and patients with insomnia. If increased BP in RLS is a consequence of disordered sleep, then it should be similar to increased BP in insomnia. METHODS: Polysomnographic recordings of patients admitted to a sleep center with RLS or insomnia were analyzed...
November 1, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27898361/movement-symptoms-in-european-moyamoya-angiopathy-first-systematic-questionnaire-study
#15
Markus Kraemer, Leonidas Trakolis, Jens Platzen, Jan Claudius Schwitalla, Anna Bersano, Philipp Albrecht, Marc Schlamann, Peter Berlit
OBJECTIVE: Movement disorders are a rare manifestation of Moyamoya angiopathy (MMA). Data on prevalence and clinical presentation are warranted. Possible involuntary movements include focal motor seizures, tremor, limb-shaking transient ischemic attacks, choreiform and spastic or dystonic movement disorders. PATIENTS AND METHODS: We developed a questionnaire to systematically assess movement disorders in MMA. Patients' history of involuntary movements and their clinical presentation were assessed systematically by interview...
January 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27863901/a-systematic-review-of-the-literature-on-disorders-of-sleep-and-wakefulness-in-parkinson-s-disease-from-2005-to-2015
#16
REVIEW
Lama M Chahine, Amy W Amara, Aleksandar Videnovic
Sleep disorders are among the most common non-motor manifestations in Parkinson's disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005 to 2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders...
August 31, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/27856776/practice-guideline-summary-treatment-of-restless-legs-syndrome-in-adults-report-of-the-guideline-development-dissemination-and-implementation-subcommittee-of-the-american-academy-of-neurology
#17
John W Winkelman, Melissa J Armstrong, Richard P Allen, K Ray Chaudhuri, William Ondo, Claudia Trenkwalder, Phyllis C Zee, Gary S Gronseth, David Gloss, Theresa Zesiewicz
OBJECTIVE: To make evidence-based recommendations regarding restless legs syndrome (RLS) management in adults. METHODS: Articles were classified per the 2004 American Academy of Neurology evidence rating scheme. Recommendations were tied to evidence strength. RESULTS AND RECOMMENDATIONS: In moderate to severe primary RLS, clinicians should consider prescribing medication to reduce RLS symptoms. Strong evidence supports pramipexole, rotigotine, cabergoline, and gabapentin enacarbil use (Level A); moderate evidence supports ropinirole, pregabalin, and IV ferric carboxymaltose use (Level B)...
December 13, 2016: Neurology
https://www.readbyqxmd.com/read/27852775/eeg-oscillations-are-modulated-in-different-behavior-related-networks-during-rhythmic-finger-movements
#18
Martin Seeber, Reinhold Scherer, Gernot R Müller-Putz
: Sequencing and timing of body movements are essential to perform motoric tasks. In this study, we investigate the temporal relation between cortical oscillations and human motor behavior (i.e., rhythmic finger movements). High-density EEG recordings were used for source imaging based on individual anatomy. We separated sustained and movement phase-related EEG source amplitudes based on the actual finger movements recorded by a data glove. Sustained amplitude modulations in the contralateral hand area show decrease for α (10-12 Hz) and β (18-24 Hz), but increase for high γ (60-80 Hz) frequencies during the entire movement period...
November 16, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27836220/does-kinesiology-taping-of-the-ankles-affect-proprioceptive-control-in-professional-football-soccer-players
#19
Daniel Bailey, Paul Firth
OBJECTIVE: To determine whether the bilateral application of kinesiology tape (KT) to professional footballers' ankles can improve their lower limb proprioception. DESIGN: A single blind randomised crossover study. Participants were randomly assigned to complete a proprioception test in either a taped or not taped condition first. Following a wash out period, participants were then re-tested in the alternate condition. SETTING: A UK Championship League Football Club, mid-season...
September 3, 2016: Physical Therapy in Sport
https://www.readbyqxmd.com/read/27833057/25-years-of-lower-limb-joint-kinematics-by-using-inertial-and-magnetic-sensors-a-review-of-methodological-approaches
#20
REVIEW
Pietro Picerno
Joint kinematics is typically limited to the laboratory environment, and the restricted volume of capture may vitiate the execution of the motor tasks under analysis. Conversely, clinicians often require the analysis of motor acts in non-standard environments and for long periods of time, such as in ambulatory settings or during daily life activities. The miniaturisation of motion sensors and electronic components, generally associated with wireless communications technology, has opened up a new perspective: movement analysis can be carried out outside the laboratory and at a relatively lower cost...
January 2017: Gait & Posture
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