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A Aberkane, W Essahib, C Spits, C De Paepe, K Sermon, T Adriaenssens, S Mackens, H Tournaye, J J Brosens, Velde H Van de
STUDY QUESTION: What are the changes in human embryos, in terms of morphology and gene expression, upon attachment to endometrial epithelial cells? SUMMARY ANSWER: Apposition and adhesion of human blastocysts to endometrial epithelial cells are predominantly initiated at the embryonic pole and these steps are associated with changes in expression of adhesion and extracellular matrix (ECM) genes in the embryo. WHAT IS KNOWN ALREADY: Both human and murine embryos have been co-cultured with Ishikawa cells, although embryonic gene expression associated with attachment has not yet been investigated in an in-vitro implantation model...
May 26, 2018: Molecular Human Reproduction
Carsten Oliver Schmidt, Christine E M Krabbe, Janka Schössow, Klaus Berger, Cornelia Enzenbach, Panagiotis Kamtsiuris, Gina Schöne, Robin Houben, Christa Meisinger, Fabian Bamberg, Thomas Hendel, Sonja Selder, Michael Nonnemacher, Susanne Moebus, Jürgen Stausberg
BACKGROUND: Cohort studies are a longitudinal observational study type. They are firmly established within epidemiology to assess the course of diseases and risk factors. Yet, standards to describe and evaluate quality characteristics of cohort studies need further development. OBJECTIVE: Within the TMF ("Technologie- und Methodenplattform für die vernetzte medizinische Forschung e. V.") project "Quality management standards in cohort studies", a catalogue of requirements was compiled and evaluated, focusing on the preparation and conduct of epidemiologic cohort studies...
January 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
F Sánchez, F Lolicato, S Romero, M De Vos, H Van Ranst, G Verheyen, E Anckaert, J E J Smitz
STUDY QUESTION: Are meiotic and developmental competence of human oocytes from small (2-8 mm) antral follicles improved by applying an optimized IVM method involving a prematuration step in presence of C-Type Natriuretic Peptide (CNP) followed by a maturation step in presence of FSH and Amphiregulin (AREG)? SUMMARY ANSWER: A strategy involving prematuration culture (PMC) in the presence of CNP followed by IVM using FSH + AREG increases oocyte maturation potential leading to a higher availability of Day 3 embryos and good-quality blastocysts for single embryo transfer...
October 1, 2017: Human Reproduction
Rob Martell, Jason T Macartney, Danielle Portnik
La technologie médicale connaît une croissance exponentielle dans le milieu de la santé, mais elle n'a toutefois pas suivi le rythme observé dans des industries similaires, telles que l'aéronautique. Les nouvelles technologies ont le potentiel d'accroître la sécurité des patients, mais si leur introduction dans le milieu de la santé n'est pas coordonnée de manière réfléchie et proactive, la chaîne de la sécurité risque de s'en trouver affaiblie, ce qui exposera les patients à des risques. Trois concepts qui représentent la chaîne de la sécurité sont décrits...
January 2017: Healthcare Management Forum
Gary R S Barron
In this paper, I describe dividing practices in making up a specific medical-legal category-the revolving door patient-to identify, label, and direct the actions of particular people living with mental illness. The revolving door patient was a category that had been spoken of for some time, but became a formal legal subject with the introduction of the Alberta Mental Health Act 2010 and Community Treatment Orders (CTOs). I demonstrate how a rationale of control over unpredictable and dangerous individuals was primary in creating this new category, and that the characterization of the revolving door patient required a disciplinary technology to reduce danger...
2016: Canadian Review of Sociology, Revue Canadienne de Sociologie
Sara Ortiz-Toquero, Guadalupe Rodriguez, Victoria de Juan, Raul Martin
PURPOSE: To determine and compare the repeatability of anterior corneal higher order aberrations (HOAs) using a Placido-based topographer (Allegro Topolyzer; WaveLight Technologie AG, Alcon Laboratories, Erlangen, Germany) in a sample of normal and keratoconic eyes. METHODS: Three repeated measurements of each cornea of normal and keratoconic eyes were taken with the Allegro Topolyzer. Repeatability of the HOAs (3rd- and 4th-order individual values and normalized polar Zernike coefficients, coma-like, root mean square (RMS) up to 8th-order values, HOA RMS, and total RMS for 6-mm pupil diameter) and central corneal power (3-mm pupil) were analyzed...
May 1, 2016: Journal of Refractive Surgery
Giacomo Savini, Arthur B Cummings, Nicole Balducci, Piero Barboni, Jinhai Huang, Marco Lombardo, Sebastiano Serrao, Pietro Ducoli
PURPOSE: To investigate agreement between the predicted ablation depth calculated by the EX500 excimer laser (Wavelight Laser Technologie AG, Erlangen, Germany) and the measured ablation depth in eyes that have undergone femtosecond laser-assisted LASIK (FS-LASIK) for myopia. METHODS: Corneal thickness was measured with a rotating Scheimpflug camera preoperatively and 3 months postoperatively and the difference between these values was defined as the measured ablation depth...
March 2016: Journal of Refractive Surgery
Taige Cao, Hong Liang Tey
Die Diagnose von Hautkrankheiten beruht derzeit, über die klinische Beurteilung hinaus, hauptsächlich auf der Histologie. Hautbiopsien haben jedoch zahlreiche Nachteile, beispielsweise Schmerzen, Narbenbildung, Infektionsrisiko und Fehler bei der Probennahme. Mit den Fortschritten bezüglich dermatologischer Bildgebungstechnologien in jüngerer Zeit eröffneten sich klinische Anwendungsmöglichkeiten von Bildgebungsmethoden bei der Behandlung von Hautkrankheiten. Vor Kurzem wurde die hochauflösende optische Kohärenztomografie (HD-OCT) für die In-vivo-Anwendung entwickelt und kommerzialisiert (Skintell®; Agfa, Belgien)...
September 2015: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
K Ounaissa, I Ksira, M Ben Romdhane, S Boumefteh, H Sfar, W Grira, A Ben Brahim, A Abid, H Jamoussi
OBJECTIFS: L'obésité infantile est un problème de santé publique. Elle constitue un véritable tremplin aux complications métaboliques et cardiovasculaires, dont l'hypertension artérielle. Les objectifs de notre étude étaient de décrire le profil tensionnel d'une population d'enfants et d'adolescents obèses et d'étudier les relations entre le profil tensionnel de ces jeunes, et d'une part les paramètres anthropométriques, et d'autre part l'alimentation spontanée. MéTHODES: Il s'agit d'une étude transversale rétrospective ayant concerné 39 enfants et adolescents obèses recrutés à l'Unité de Recherche sur l'Obésité Humaine à l'Institut National de Nutrition et de Technologie Alimentaire de Tunis...
December 2015: Annales de Cardiologie et D'angéiologie
Anastasios John Kanellopoulos, George Asimellis
PURPOSE: To evaluate the safety, efficacy, and refractive and keratometric stability of myopic femtosecond laser in situ keratomileusis (LASIK) with concurrent prophylactic high-fluence corneal collagen crosslinking (CXL) compared with the outcomes of standard femtosecond LASIK. SETTING: Private clinical practice, Athens, Greece. DESIGN: Consecutive randomized prospective comparative study. METHODS: Eyes that had myopic LASIK or myopic LASIK with concurrent high-fluence CXL were evaluated preoperatively and up to 2 years postoperatively for manifest refraction spherical equivalent (MRSE), refractive astigmatism, visual acuity, corneal keratometry (K), and endothelial cell count...
July 2015: Journal of Cataract and Refractive Surgery
Jennifer Whitty, Alexandra Filby, Adam B Smith, Louise M Carr
OBJECTIVES: Differences in the process of using liver imaging technologies might be important to patients. This study aimed to investigate preferences for scanning modalities used in diagnosing focal liver lesions. METHODS: A discrete choice experiment was administered to 504 adults aged 25 ≥years. Respondents made repeated choices between two hypothetical scans, described according to waiting time for scan and results, procedure type, the chance of minor side-effects, and whether further scanning procedures were likely to be required...
January 2015: International Journal of Technology Assessment in Health Care
Anastasios John Kanellopoulos, George Asimellis, Stella Georgiadou
PURPOSE: To compare postoperative changes in apparent photopic and mesopic pupil size and centration in relation to cornea reflection landmarks after cataract surgery. SETTING: Clinical and Research Eye Institute, Athens, Greece. DESIGN: Prospective consecutive case study. METHODS: Pupils were imaged for pupil size and corneal vertex location before and 1-month after cataract surgery. Digital analysis of pupil images was used to determine the Cartesian coordinates (nasal-temporal, horizontal axis, superior-inferior, vertical axis) of the first Purkinje reflection point (approximating the corneal intersection of the visual axis [corneal vertex]) to the pupil geometric center (approximating the corneal intersection of the line of sight [corneal apex])...
February 2015: Journal of Cataract and Refractive Surgery
Anastasios John Kanellopoulos, George Asimellis
PURPOSE: To compare epithelial remodeling in keratoconic eyes that had photorefractive keratectomy and corneal collagen crosslinking (Athens protocol) with that in untreated keratoconic eyes and healthy eyes. SETTING: Private clinical practice, Athens, Greece. DESIGN: Comparative case series. METHODS: Fourier-domain anterior segment optical coherence tomography (AS-OCT) was used to obtain in vivo 3-dimensional epithelial thickness maps and center, superior, inferior, maximum, minimum, mean, midperipheral, and variability data...
October 2014: Journal of Cataract and Refractive Surgery
J Kuhtz, S Romero, M De Vos, J Smitz, T Haaf, E Anckaert
STUDY QUESTION: Does in vitro maturation (IVM) of cumulus-enclosed germinal vesicle (GV) stage oocytes retrieved from small antral follicles in minimally stimulated cycles without an ovulatory hCG dose induce imprinting errors at LIT1, SNRPN, PEG3 and GTL2 in human oocytes? SUMMARY ANSWER: There is no significant increase in imprinting mutations at LIT1, SNRPN, PEG3 and GTL2 after IVM of cumulus-enclosed GV oocytes from small antral follicles in minimally stimulated cycles without hCG priming...
September 2014: Human Reproduction
Giacomo Savini, Antonio Calossi, Massimo Camellin, Francesco Carones, Marco Fantozzi, Kenneth J Hoffer
PURPOSE: To evaluate whether the refractive changes induced by excimer laser surgery can be accurately measured by corneal ray tracing performed by a combined rotating Scheimpflug camera-Placido-disk corneal topographer (Sirius). SETTING: Private practices. DESIGN: Evaluation of diagnostic test. METHODS: This multicenter retrospective study comprised patients who had myopic or hyperopic excimer laser refractive surgery...
July 2014: Journal of Cataract and Refractive Surgery
Philippe Merviel, Rosalie Cabry, Emmanuelle Lourdel, Frédéric Barbier, Florence Scheffler, Naïma Mansouri, Aviva Devaux, Moncef Benkhalifa, Henri Copin
The intrauterine insemination with husband's sperm is an assisted reproductive technologie, as proposed in the case of cervical infertility, moderate male infertility, dysovulation, mild or moderate endometriosis or unexplained infertility. In the last three indications the ovarian stimulation is necessary. The couple demographic criteria (age of both partners, lifestyle, duration of infertility) and the results of the infertility evaluation (ovarian reserve, uterus, spermogram-spermocytogram) increase the chances of pregnancy by intrauterine insemination with husband's sperm and reduce the risk of multiple pregnancies...
January 2014: La Revue du Praticien
Esmeralda Costa, Nuno Franqueira, Andreia M Rosa, Cristina Tavares, Maria J Quadrado, Conceição Lobo, Joaquim N Murta
To analyze photorefractive keratectomy (PRK) outcomes in myopia and myopic astigmatism correction using the WaveLight Allegretto Wave Eye-Q(®) excimer laser system (WaveLight Laser Technologie AG, Erlangen, Germany). 222 eyes of 151 patients underwent PRK (mean age 33.5 ± 6.8 years). Pre-operative best spectacle-corrected visual acuity (BSCVA) ranged from 0.4 to -0.1 logMAR (mean -0.03 ± 0.06). Mean spherical equivalent (SE) was -3.29 ± 1.20 D. Efficacy, predictability and safety were evaluated. Minimum follow-up was 3 months...
June 2014: International Ophthalmology
I Guber, L Moetteli, L Magnin, F Majo
BACKGROUND: To evaluate outcomes after optimized laser in situ keratomileusis (LASIK) for astigmatism correction with flap created by a mechanical microkeratome or a femtosecond laser. PATIENTS AND METHODS: In this retrospective study, a total of 102 eyes of 71 consecutive patients were enrolled undergoing optimized LASIK treatments using the Allegretto laser system (WaveLight Laser Technologie AG, Erlangen, Germany). A mechanical microkeratome for flap creation was used (One Use, Moria®) in 46 eyes (31 patients, spherical equivalent [SE] -4...
April 2013: Klinische Monatsblätter Für Augenheilkunde
R Geßler
Barley samples (n = 128) from Central Canada (Manitoba) of the 1993 and 1994 crop years were analysed using enzyme immunoassays for the detection of the mycotoxins deoxy-nivalenol, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, and zearalenone. For this study enzyme immunoassays, which were developed at the Lehrstuhl für Hygiene und Technologie der Milch as well as a commercial testkit (Ridascreen® DON, specific for deoxynivalenol and its acetylated derivatives) were used. In addition, some samples were analysed by using a combination of HPLC and enzyme immunoassay (immunochromatography)...
March 1997: Mycotoxin Research
A Mertzanidou, L Wilton, J Cheng, C Spits, E Vanneste, Y Moreau, J R Vermeesch, K Sermon
STUDY QUESTION: What are the aneuploidy rates and incidence of mosaicism in good-quality human preimplantation embryos. SUMMARY ANSWER: High-level mosaicism and structural aberrations are not restricted to arrested or poorly developing embryos but are also common in good-quality IVF embryos. WHAT IS KNOWN ALREADY: Humans, compared with other mammals, have a poor fertility rate, and even IVF treatments have a relatively low success rate. It is known that human gametes and early preimplantation embryos carry chromosomal abnormalities that are thought to lower their developmental potential...
January 2013: Human Reproduction
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