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https://www.readbyqxmd.com/read/29928079/versatile-use-of-dermal-substitutes-a-retrospective-survey-of-127-consecutive-cases
#1
Giovanni Nicoletti, Marco Mario Tresoldi, Alberto Malovini, Marco Visaggio, Angela Faga, Silvia Scevola
Background: Dermal substitutes are currently largely used for the treatment of huge skin loss in patients in critical general health conditions, for the treatment of severe burns and to promote the healing process in chronic wounds. Aims: The authors performed a retrospective assessment of their experience with bioengineered skin to possibly identify the most appropriate clinical indication and management for each substitute. Materials and Methods: The study involved 109 patients with 127 skin defects repaired with dermal substitutes over a 9 years period, from 2007 to 2016...
January 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29927863/endoscopic-esophageal-vacuum-therapy-a-novel-therapy-for-esophageal-perforations-in-pediatric-patients
#2
Michael A Manfredi, Susannah J Clark, Steven J Staffa, Peter D Ngo, C Jason Smithers, Thomas E Hamilton, Russell W Jennings
BACKGROUND: Esophageal perforation is a potentially life-threatening problem if not quickly diagnosed and treated appropriately. Negative pressure wound therapy (NPWT), commercially known as V.A.C.® therapy, was developed in the early 1990 s and is now standard of care for chronic surface wounds, ulcers, and burns. Adapting vacuum sponge therapy for use intraluminally for perforations of the esophagus was first reported in 2008. We report the first pediatric experience on a customized esophageal vacuum assisted closure (EVAC) device for closure of esophageal perforations...
June 20, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29927824/intracranial-hypotension-and-hypertension-associated-with-reconstructive-cranioplasty-after-decompressive-craniectomy-report-of-a-lethal-complication-with-recommended-strategies-for-future-avoidance
#3
Cecilia L Dalle Ore, Peter Abraham, Luke P Burns, Samuel Lance, Amanda Gosman, Hal S Meltzer
Reconstructive cranioplasty can be associated with many complications and add to the not insignificant potential risks associated with decompressive craniectomy. In the setting of post-traumatic hydrocephalus, treatment with a ventriculoperitoneal (VP) shunt prior to reconstructive cranioplasty likely increases these risks even further. The authors report a case of a 17-year-old male with a history of a severe closed head injury who initially suffered a life-threatening complication associated with intracranial hypotension after cranioplasty only to succumb to malignant intracranial hypertension following a second cranioplasty attempt...
June 20, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29926533/incidence-and-characteristics-of-the-nocebo-response-from-meta-analyses-of-the-placebo-arms-of-clinical-trials-of-olanzapine-for-bipolar-disorder
#4
Seetal Dodd, Adam J Walker, Alan J M Brnabic, Nancy Hong, Amber Burns, Michael Berk
OBJECTIVES: In the clinical setting, the nocebo phenomenon is where clinical worsening or adverse events occur as a response to a treatment, in a situation in which conditioning from previous treatment exposure and/or expectations of sickness or symptoms lead to sickness and symptoms in a conditioned or expectant individual. The nocebo response may thus be a confounder in clinical treatment and clinical research. There is a need to know how to predict if an individual is likely to be a nocebo responder, and how significant and commonplace the nocebo effect might be...
June 21, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29926301/ugandan-study-participants-experience-electronic-monitoring-of-antiretroviral-therapy-adherence-as-welcomed-pressure-to-adhere
#5
Jeffrey I Campbell, Nir Eyal, Angella Musiimenta, Bridget Burns, Sylvia Natukunda, Nicholas Musinguzi, Jessica E Haberer
Many new technologies monitor patients' and study participants' medical adherence. Some have cautioned that these devices transgress personal autonomy and ethics. But do they? This qualitative study explored how Ugandan study participants perceive the effect of electronic monitoring of their adherence to antiretroviral therapy (ART) on their freedoms to be non-adherent and pursue other activities that monitoring may inadvertently expose. Between August 2014 and June 2015, we interviewed 60 Ugandans living with HIV and enrolled in the Uganda AIDS Rural Treatment Outcomes (UARTO) study, a longitudinal, observational study involving electronic adherence monitors (EAMs) to assess ART adherence...
June 20, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29924242/treatment-of-cutaneous-leishmaniasis-with-thermotherapy-in-brazil-an-efficacy-and-safety-study
#6
Sheila Viana Castelo Branco Gonçalves, Carlos Henrique Nery Costa
BACKGROUND: Pentavalent antimonials remain as the standard drugs in the treatment of cutaneous leishmaniosis. The high cost, difficult administration, long treatment time, toxicity and increasing morbidity are factors that limit the use of these drugs. OBJECTIVES: To describe the response to radiofrequency thermotherapy in the treatment of localized cutaneous leishmaniasis in Brazil, and to evaluate its safety and tolerability. METHODS: We conducted a non-comparative open trial with a total of 15 patients confirmed to have cutaneous leishmaniasis on parasitological examination...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29923901/treatment-of-genital-burn-injuries-traditional-procedures-and-new-techniques
#7
Alexandra Schulz, Benedikt Ribitsch, Paul Christian Fuchs, Alexandra Lipensky, Jennifer Lynn Schiefer
OBJECTIVE: Because genital burns are rare, only limited information on treatment guidelines is available in the literature. Vital tissue should be preserved to promote spontaneous healing because reconstruction does not always lead to satisfying results. The aim of this report is to present a general overview of current, prevailing treatment for genital burns and compare this to study authors' experiences. In addition, the article describes an entirely new approach of tissue-preserving bromelain-based enzymatic debridement of genital burn wounds...
July 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29923030/-chemical-burns-caused-by-crust-anemone
#8
A Gaudchau, N Pfeiffer, A Gericke
We present a case of a toxic reaction in both eyes caused by secretions from an encrusting anemone of the genus Protopalythoa. The patient presented with chemosis and follicular reaction of the conjunctiva and whitish spots on the limbus. Under local treatment with steroids and antibiotic eyedrops, remission was achieved within a few days. Palytoxin, a poisonous component of Protopalythoa secretions, leads to inhibition of the sodium-potassium-ATPase, to destabilization of the membrane potential and to cell death...
June 19, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29922749/assessment-of-pain-quality-reveals-distinct-differences-between-nociceptive-innervation-of-low-back-fascia-and-muscle-in-humans
#9
Andreas Schilder, Walter Magerl, Thomas Klein, Rolf-Detlef Treede
Introduction/Objectives: Verbal descriptors are an important pain assessment parameter. The purpose of this study was to explore the ability to discriminate deep muscle pain and overlying fascia pain according to verbal descriptors and compare the pattern with skin stimulation (from previously published data). Methods: In 16 healthy human subjects, electrical stimulation was chosen to excite a broad spectrum of nociceptive primary afferents innervating the respective tissues...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29922525/spanning-external-fixation-for-the-treatment-of-open-joint-injuries-in-pediatric-burn-patients
#10
Kelly Carmichael, Daniel Torres, Carlos J Jimenez, Matthew C Comley, Ernest B Evans
In this article, we report a case series on spanning external fixation for the treatment of open joint burn injuries in a pediatric population. We reviewed the case logs of all orthopedic surgeons from 2000 to 2010 at a burn hospital to identify pediatric patients with open joints secondary to burn injuries. Nine patients who sustained open joint injuries after a burn and treated with a spanning external fixator (SEF) were identified. Characteristics of the burns included: five elbow, four knee; seven flame, two electrical; average total body surface area affected 49...
April 16, 2018: Curēus
https://www.readbyqxmd.com/read/29916601/integrating-and-monitoring-hand-burn-rehabilitative-treatment-using-virtual-reality
#11
Monica Pusineri, Serena Monteleone, Elisabetta De Bernardi, Ambrogina Lanzi, Claudio Lisi, Elena Dalla Toffola, Ettore Carlisi
OBJECTIVES: Hand burn is not a common condition in the clinical practice and needs a long and laboured rehabilitative treatment to restore the lost function. METHODS: This case report illustrates the achievable improvements in mobility and function by using innovative inertial systems for occupational exercise in a Virtual Reality, in addition to a traditional rehabilitative treatment. RESULTS: Through these instruments, we could promote and concurrently assess the recovery of a functional grasp and the ability in the execution of Activities of Daily Living...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29915642/patient-preferences-and-therapeutic-satisfaction-with-topical-agents-for-rosacea-a-survey-based-study
#12
Todd Williamson, Wendy Y Cheng, Nora McCormick, Francis Vekeman
Background: Rosacea is a chronic inflammatory skin disorder that primarily affects the convexities of the central face. Depending on the severity and type of rosacea, physicians may prescribe interventions such as behavioral changes, laser and intense pulsed light, as well as various pharmacologic therapies, including topical agents. The impact of side effects associated with topical treatments for rosacea on patient preferences and treatment satisfaction is not well-documented. Objective: To assess patients' concerns, treatment satisfaction, and quality of life (QOL) associated with topical treatments for rosacea...
April 2018: American Health & Drug Benefits
https://www.readbyqxmd.com/read/29914495/exploring-perceptions-of-common-practices-immediately-following-burn-injuries-in-rural-communities-of-bangladesh
#13
Animesh Biswas, Abu Sayeed Md Abdullah, Koustuv Dalal, Toity Deave, Fazlur Rahman, Saidur Rahman Mashreky
BACKGROUND: Burns can be the most devastating injuries in the world, they constitute a global public health problem and cause widespread public health concern. Every year in Bangladesh more than 365,000 people are injured by electrical, thermal and other causes of burn injuries. Among them 27,000 need hospital admission and over 5600 people die. Immediate treatment and medication has been found to be significant in the success of recovering from a burn. However, common practices used in the treatment of burn injuries in the community is not well documented in Bangladesh...
June 18, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29913873/postherpetic-neuralgia-new-hopes-in-prevention-with-adult-vaccination-and-in-treatment-with-a-concentrated-capsaicin-patch
#14
Ewa Gawecka, Oddbjørn Viken
Background and purpose Postherpetic neuralgia (PHN) is a complication of acute herpes zoster (HZ). The evidence base for management of PHN has increased by recent publications. Therefore, we reviewed incidence of HZ, prevalence, risk factors, and mechanism of PHN pain, prevention and treatment of PHN with special interest in studies on adult vaccination and topical application of lidocaine and concentrated capsaicin patch. Methods We searched databases with an English language restriction: MEDLINE 1944-2011, EMBASE 1988-2011, PubMed, and the Cochrane Controlled Trial Register and Cochrane Library (2011)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913375/versatile-graphene-biosensors-for-enhancing-human-cell-therapy
#15
REVIEW
George M Vlăsceanu, Roxana-Maria Amărandi, Mariana Ioniță, Teddy Tite, Horia Iovu, Luisa Pilan, Jorge S Burns
Technological advances in engineering and cell biology stimulate novel approaches for medical treatment, in particular cell-based therapy. The first cell-based gene therapy against cancer was recently approved by the US Food and Drug Administration. Progress in cancer diagnosis includes a blood test detecting five cancer types. Numerous stem cell phase I/II clinical trials showing safety and efficacy will soon pursue qualifying criteria for advanced therapy medicinal products (ATMP), aspiring to join the first stem-cell therapy approved by the European Medicines Agency...
May 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29913093/recent-advances-in-the-etiology-and-treatment-of-burning-mouth-syndrome
#16
A Ritchie, J M Kramer
Burning mouth syndrome (BMS) is a debilitating condition that has a striking female predilection. Although the oral mucosa is normal in appearance, patients with BMS experience oral burning that most commonly localizes to the lips and tongue. BMS is a diagnosis of exclusion, and all underlying pathoses associated with allodynia must be ruled out prior to rendering the diagnosis. The etiopathogenesis of BMS remains poorly understood, and thus patient management is challenging. Data indicate that oral and systemic factors both contribute to the development and persistence of the condition...
June 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29911087/retrospective-study-to-evaluate-the-treatment-of-digital-pulp-lesions-using-a-homodigital-flap
#17
Tarsila Pagnan Silva Dos Santos, Marcelo Tavares de Oliveira, Luiz Carlos Angelini
Objective: To assess the homodigital flap surgical procedure, as well as the function of the finger, pain, sensation, esthetics, and patient satisfaction. Method: Retrospective analysis of records and questionnaires of patients who underwent this surgical technique between the months of May 2013 and October 2016. Eight were included in the study, with an average follow-up period of 23 months. Patients with digital pulp lesions of the thumbs and those who did not perform rehabilitation were excluded...
March 2018: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29906578/immediate-and-long-term-outcomes-of-microvascular-decompression-for-mixed-trigeminal-neuralgia
#18
Adela Wu, Tina Doshi, Alice Hung, Tomas Garzon-Muvdi, Matthew T Bender, Chetan Bettegowda, Michael Lim
OBJECTIVE: Classic trigeminal neuralgia (TN) involves sharp, shooting pain in any trigeminal nerve distribution, whereas atypical TN presents with constant aching, numbness or burning that can appear with classic features, leading to a mixed presentation. Microvascular decompression (MVD) is an effective treatment for classic TN, but its utility in treating mixed TN is less studied. METHODS: We retrospectively studied 73 adult patients with mixed TN and 386 classic TN patients, who all underwent MVD between December 2007 and October 2016...
June 12, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29905673/blood-brain-barrier-dysfunction-after-smoke-inhalation-injury-with-and-without-skin-burn
#19
Anita C Randolph, Satoshi Fukuda, Koji Ihara, Perenlei Enkhbaatar, Maria-Adelaide Micci
Only a handful of published reports exist today that describe neurological complications following smoke inhalation injury. In this study, we characterize acute pathophysiological changes in the brain of sheep exposed to smoke inhalation, with- and without third-degree skin burn that models the injuries sustained by human victims of fire accidents. Blood-brain barrier integrity and hemorrhage were analyzed throughout the brain using specific histological stains: Hematoxylin & Eosin, Luxol fast blue, Periodic acid-Schiff (PAS), and Martius, Scarlet and Blue (MSB)...
June 13, 2018: Shock
https://www.readbyqxmd.com/read/29905137/getting-past-dax
#20
Monica L Gerrek
Much has been written about Dax Cowart's tragic burn injury, treatment, and recovery. While Dax's case is certainly important to conversations regarding decision making in burn care, his is not the only story there is. In this article, the case of Andrea Rubin, also a severe burn survivor, is introduced as another voice in this conversation. Her experience during treatment and recovery is very different from Dax's and should cause us to at least pause and reconsider how we think about treatment and decision making in burn care...
June 1, 2018: AMA Journal of Ethics
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