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https://www.readbyqxmd.com/read/29236145/-non-coding-rna-innovative-regulators-with-therapeutic-perspective
#1
A Bührke, C Bär, T Thum
As a result of the Human Genome Project it became evident that only 1-3% of all gene transcripts encode proteins. The vast majority of gene transcripts are in fact characterized as non-coding RNAs (ncRNAs). These ncRNAs have a huge impact on diverse physiological and pathological mechanisms within an organism. In particular, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), which are differentiated by their size and function, are involved in the regulation and development of many illnesses. In the context of heart and cardiovascular diseases numerous ncRNAs have also already been described in some detail...
December 13, 2017: Herz
https://www.readbyqxmd.com/read/29235840/a-newly-designed-covalent-triazine-framework-based-on-novel-n-heteroaromatic-building-block-for-efficient-co2-and-h2-capture-and-storage
#2
Guangbo Wang, Karen Leus, Shuna Zhao, Pascal Van Der Voort
In this article, a set of novel covalent triazine frameworks were prepared by trimerization of 4,4',4'',4'''-(1,4-phenylenebis(pyridine-4,2,6-triyl))tetrabenzonitrile in molten ZnCl2 under ionothermal conditions. The influence of several parameters such as the ZnCl2/monomer ratio and reaction temperature on the structure and porosity of the resulting frameworks was systematically examined. After a thorough characterization, their performance in H2 and CO2 adsorption as well as their selectivity of CO2 over N2 was assessed...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235052/salvage-fractionated-stereotactic-re-irradiation-fsrt-for-patients-with-recurrent-high-grade-gliomas-progressed-after-bevacizumab-treatment
#3
Wenyin Shi, Erik S Blomain, Joshua Siglin, Joshua J Palmer, Tu Dan, Yang Wang, Maria Werner-Wasik, Jon Glass, Lyndon Kim, Voichita Bar Ad, Deepak Bhamidipati, James J Evans, Kevin Judy, Christopher J Farrell, David W Andrews
Bevacizumab failure is a major clinical problem in the management of high grade gliomas (HGG), with a median overall survival (OS) of < 4 months. This study evaluated the feasibility and efficacy of fractionated stereotactic re-irradiation (FSRT) for patients progressed after Bevacizumab treatment. Retrospective review was conducted of 36 patients treated with FSRT after progression on bevacizumab. FSRT was most commonly delivered in 3.5 Gy fractions to a total dose of 35 Gy. Survival from initial diagnosis, as well as from recurrence and re-irradiation, were utilized as study endpoints...
December 12, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29234869/a-controlled-trial-of-inhaled-bronchodilators-in-familial-dysautonomia
#4
Bat-El Bar-Aluma, Ori Efrati, Horacio Kaufmann, Jose-Alberto Palma, Lucy Norcliffe-Kaufmann
BACKGROUND: Chronic lung disease is a leading cause of premature death in patients with familial dysautonomia (FD). A significant number of patients have obstructive airway disease, yet it is not known whether this is pharmacologically reversible. METHODS: We conducted a double-blind, placebo-controlled, randomized clinical trial comparing the beta 2 agonist albuterol with the muscarinic blocker ipratropium bromide in patients homozygous for the IKBKAP founder mutation...
December 12, 2017: Lung
https://www.readbyqxmd.com/read/29234759/a-sims-study-of-cation-and-anion-diffusion-in-tantalum-oxide
#5
U N Gries, H Schraknepper, K Skaja, F Gunkel, S Hoffmann-Eifert, R Waser, R A De Souza
Ion transport in ceramics of the low-temperature phase of tantalum pentoxide, L-Ta2O5, was examined by means of diffusion experiments and subsequent analysis of diffusion profiles with time-of-flight secondary ion mass spectrometry (ToF-SIMS). 18O/16O isotope anneals were used to investigate oxygen diffusion, and oxygen tracer diffusion coefficients were obtained for the temperature range of 623 ≤ T/K ≤ 873 at an oxygen partial pressure of pO2 = 0.2 bar and for the oxygen partial pressure range of 10-2 ≤ pO2/bar ≤ 100 at a temperature of T = 723 K...
December 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29234725/computerized-cognitive-training-for-older-diabetic-adults-at-risk-of-dementia-study-protocol-for-a-randomized-controlled-trial
#6
Rachel Bloom, Michal Schnaider-Beeri, Ramit Ravona-Springer, Anthony Heymann, Hai Dabush, Lior Bar, Shirel Slater, Yuri Rassovsky, Alex Bahar-Fuchs
Introduction: Older adults with type 2 diabetes are at high risk of cognitive decline and dementia and form an important target group for dementia risk reduction studies. Despite evidence that computerized cognitive training (CCT) may benefit cognitive performance in cognitively healthy older adults and those with mild cognitive impairment, whether CCT may benefit cognitive performance or improve disease self-management in older diabetic adults has not been studied to date. In addition, whether adaptive difficulty levels and tailoring of interventions to individuals' cognitive profile are superior to generic training remains to be established...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29233974/author-correction-nanoscale-control-of-competing-interactions-and-geometrical-frustration-in-a-dipolar-trident-lattice
#7
Alan Farhan, Charlotte F Petersen, Scott Dhuey, Luca Anghinolfi, Qi Hang Qin, Michael Saccone, Sven Velten, Clemens Wuth, Sebastian Gliga, Paula Mellado, Mikko J Alava, Andreas Scholl, Sebastiaan van Dijken
The original version of this article contained an error in the legend to Figure 4. The yellow scale bar should have been defined as '~600 nm', not '~600 µm'. This has now been corrected in both the PDF and HTML versions of the article.
December 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29232648/template-directed-fabrication-of-mil-101-cr-mesoporous-silica-composite-layer-packed-structure-and-enhanced-performance-for-co2-capture
#8
Chong Chen, Nengjie Feng, Qirui Guo, Zhong Li, Xue Li, Jing Ding, Lei Wang, Hui Wan, Guofeng Guan
A novel hybrid material constituted of MIL-101(Cr) and mesoporous silica was successfully assembled through an in-situ hydrothermal method. The MCM-41 with well-ordered mesopores acted as the structure-directing agent, which regulated the growth of MIL-101(Cr) crystals along a certain direction and restricted the expansion of framework. Meanwhile, the hydroxyl groups existed in MCM-41 preferentially coordinated with the Cr3+ centers in MOF, followed by the layer-packed arrangement of MIL-101(Cr) nanocrystals on the surface of matrix...
December 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29231039/alcohol-service-practices-a-survey-of-bar-and-restaurant-managers
#9
Dawn M Nederhoff, Kathleen M Lenk, Keith J Horvath, Toben F Nelson, Alexandra M Ecklund, Darin J Erickson, Traci L Toomey
Excessive alcohol consumption can result from illegal sales to intoxicated patrons at bars and restaurants. We surveyed bar/restaurant managers about their practices in reducing illegal sales to intoxicated patrons. We found that managers were confident that they could refuse service to intoxicated customers but were less likely to have communicated necessary information to their staff on how to refuse such sales. Managers who agreed that a business in their community would be cited for overservice were more likely to be confident that they could handle customers who had been cut off from alcohol service...
January 1, 2017: Journal of Drug Education
https://www.readbyqxmd.com/read/29231023/-analysis-on-the-injury-mechanism-and-characteristics-of-ox-horn
#10
W L Zhang, Y L Du
OBJECTIVES: To study the morphological characteristics of the injury caused by ox horn on human body and its injury mechanism, and to discuss the rules and characteristics of injury by ox horn and provide forensic evidences for identification of such cases. METHODS: The comparative analysis of position and morphological characteristics were performed by summarizing the data of 100 victims gored by ox accepted by Heilongjiang agricultural areas public security bureau during 2004-2014...
April 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29230952/children-tolerate-intradialytic-oral-nutrition
#11
Andrew M South, Bonnie Fainman, Scott M Sutherland, Cynthia J Wong
BACKGROUND: People undergoing haemodialysis (HD) often have poor nutrition, which in turn can contribute to worse outcomes. Inadequate nutrition has a particularly deleterious effect on growth and neurocognitive development, as well as mortality, in children and adolescents. Nutritional supplementation can improve outcomes but can be difficult to administer. OBJECTIVE: Determine the tolerability of intradialytic oral nutrition in children and adolescents. DESIGN: A cross-sectional quality improvement study in an outpatient paediatric HD unit...
December 12, 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/29230070/assessing-climate-change-impacts-on-the-stability-of-small-tidal-inlets-part-2-data-rich-environments
#12
Trang Minh Duong, Roshanka Ranasinghe, Marcus Thatcher, Sarith Mahanama, Zheng Bing Wang, Pushpa Kumara Dissanayake, Mark Hemer, Arjen Luijendijk, Janaka Bamunawala, Dano Roelvink, Dirkjan Walstra
Climate change (CC) is likely to affect the thousands of bar-built or barrier estuaries (here referred to as Small tidal inlets - STIs) around the world. Any such CC impacts on the stability of STIs, which governs the dynamics of STIs as well as that of the inlet-adjacent coastline, can result in significant socio-economic consequences due to the heavy human utilisation of these systems and their surrounds. This article demonstrates the application of a process based snap-shot modelling approach, using the coastal morphodynamic model Delft3D, to 3 case study sites representing the 3 main STI types; Permanently open, locationally stable inlets (Type 1), Permanently open, alongshore migrating inlets (Type 2) and Seasonally/Intermittently open, locationally stable inlets (Type 3)...
January 1, 2018: Marine Geology
https://www.readbyqxmd.com/read/29229670/kras-and-tumor-immunity-friend-or-foe
#13
Jane Cullis, Shipra Das, Dafna Bar-Sagi
With the recent breakthroughs in immunotherapy as curative treatments in certain tumor types, there has been renewed interest in the relationship between immunity and tumor growth. Although we are gaining a greater understanding of the complex interplay of immune modulating components in the tumor microenvironment, the specific role that tumor cells play in shaping the immune milieu is still not well characterized. In this review, we focus on how mutant Kras tumor cells contribute to tumor immunity, with a specific focus on processes induced directly or indirectly by the oncogene...
December 11, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29229655/new-zealand-policy-experts-appraisal-of-interventions-to-reduce-smoking-in-young-adults-a-qualitative-investigation
#14
Jude Ball, Janet Hoek, El Shadan Tautolo, Heather Gifford
OBJECTIVES: Reducing smoking in young adults, particularly young Māori and Pacific, is vital for reducing tobacco harm and health inequalities in New Zealand (NZ). We investigated how NZ policy experts appraised the feasibility and likely effectiveness of interventions designed to reduce smoking prevalence among 18-24 year olds. DESIGN: We used a qualitative design, conducting semistructured interviews and applying thematic analysis. PARTICIPANTS: We interviewed 15 key informants, including politicians, senior policy analysts and leading tobacco control advocates...
December 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/29229564/alternative-myplate-menus-effects-of-ultra-processed-foods-on-saturated-fat-sugar-and-sodium-content
#15
Marilyn Tseng, Dawn B Neill, Stephanie F Teaford, Aydin Nazmi
OBJECTIVE: Compare saturated fat, sugar, and sodium in the US Department of Agriculture sample menu with a version in which menu items were replaced with comparable ultra-processed foods. DESIGN AND SETTING: The authors modified 7 days of a US Department of Agriculture sample menu providing approximately 2,000 kcal/d by replacing foods with comparable ultra-processed alternatives and then visited 2 chain supermarkets in San Luis Obispo, CA (August, 2016) to locate shopping list items for the 2 menu versions...
December 8, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29227234/could-you-buy-me-a-beer-measuring-secondary-supply-of-alcohol-in-dutch-on-premise-outlets
#16
Ruud T J Roodbeen, Suzie Geurtsen, Karen Schelleman-Offermans
OBJECTIVE: Alcohol is largely available for Dutch minors through on-premise secondary supply, which occurs when an adult furnishes an alcoholic drink to a minor in an on-premise outlet. Vendors allowing this secondary supply on their premises are in violation of the Dutch Licensing and Catering Act (legal age limit is 18 years old for the sale and possession of alcohol). Using existing mystery shopping protocols as a standard, our study objective was the development and field testing of a novel procedure, measuring vendors' compliance with secondary supply...
January 2018: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/29226443/lessons-from-analyzing-the-medical-costs-of-civilian-terror-victims-planning-resources-allocation-for-a-new-era-of-confrontations
#17
Eytan Ellenberg, Mark I Taragin, Jay R Hoffman, Osnat Cohen, Daniella Luft-Afik, Zvia Bar-On, Ishay Ostfeld
Policy Points: Across the globe, the threat from terrorist attacks is rising, which requires a careful assessment of long-term medical support. We found 3 major sources of costs: hospital expenditures, mental health services dedicated to acute stress reactions, and ambulatory follow-up. During the first year, most of the costs were related to hospitalization and support for stress relief. During the second year, ambulatory and rehabilitation costs continued to grow. Public health specialists should consider these major components of costs and their evolution over time to properly advise the medical and social authorities on allocating resources for the medical and nonmedical support of civilian casualties resulting from war or terror...
December 2017: Milbank Quarterly
https://www.readbyqxmd.com/read/29226437/on-effective-graphic-communication-of-health-inequality-considerations-for-health-policy-researchers
#18
Yukiko Asada, Hannah Abel, Chris Skedgel, Grace Warner
Policy Points: Effective graphs can be a powerful tool in communicating health inequality. The choice of graphs is often based on preferences and familiarity rather than science. According to the literature on graph perception, effective graphs allow human brains to decode visual cues easily. Dot charts are easier to decode than bar charts, and thus they are more effective. Dot charts are a flexible and versatile way to display information about health inequality. Consistent with the health risk communication literature, the captions accompanying health inequality graphs should provide a numerical, explicitly calculated description of health inequality, expressed in absolute and relative terms, from carefully thought-out perspectives...
December 2017: Milbank Quarterly
https://www.readbyqxmd.com/read/29223704/decellularized-heart-ecm-hydrogel-using-supercritical-carbon-dioxide-for-improved-angiogenesis
#19
Yoojin Seo, Youngmee Jung, Soo Hyun Kim
Initial angiogenesis within the first 3 days is critical for healing ischemic diseases such as myocardial infarction. Recently, decellularized extracellular matrix (dECM) has been reported to provide tissue-derived ECM components and can be used as a scaffold for cell delivery for angiogenesis in tissue engineering. Decellularization by various detergents such as sodium dodecyl sulfate (SDS) and triton X-100 can remove the cell nuclei in tissue organs. However, this leads to ECM structure denaturation, decreased presence of various ECM proteins and cytokines, and loss of mechanical properties...
December 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29223667/selective-versus-routine-patch-metal-allergy-testing-to-select-bar-material-for-the-nuss-procedure-in-932-patients-over-10years
#20
Robert J Obermeyer, Sheema Gaffar, Robert E Kelly, M Ann Kuhn, Frazier W Frantz, Margaret M McGuire, James F Paulson, Cynthia S Kelly
AIM OF THE STUDY: The aim of the study was to determine the role of patch metal allergy testing to select bar material for the Nuss procedure. METHODS: An IRB-approved (11-04-WC-0098) single institution retrospective, cohort study comparing selective versus routine patch metal allergy testing to select stainless steel or titanium bars for Nuss repair was performed. In Cohort A (9/2004-1/2011), selective patch testing was performed based on clinical risk factors...
November 14, 2017: Journal of Pediatric Surgery
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