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Yotam E Bar-Ephraim, Ferry Cornelissen, Natalie Papazian, Tanja Konijn, Remco M Hoogenboezem, Mathijs A Sanders, Bart A Westerman, Mehmet Gönültas, Jaap Kwekkeboom, Joke M M Den Haan, Rogier M Reijmers, Reina E Mebius, Tom Cupedo
A substantial number of human and mouse group 3 innate lymphoid cells (ILC3s) reside in secondary lymphoid organs, yet the phenotype and function of these ILC3s is incompletely understood. Here, we employed an unbiased cross-tissue transcriptomic approach to compare human ILC3s from non-inflamed lymph nodes and spleen to their phenotypic counterparts in inflamed tonsils and from circulation. These analyses revealed that, in the absence of inflammation, lymphoid organ-residing ILC3s lack transcription of cytokines associated with classical ILC3 functions...
October 17, 2017: Cell Reports
Eric K W Poon, Vikas Thondapu, Eve Revalor, Andrew Ooi, Peter Barlis
No abstract text is available yet for this article.
October 17, 2017: European Heart Journal
Arthur Lefevre, Raphaëlle Mottolese, Jérôme Redouté, Nicolas Costes, Didier Le Bars, Marie-Maude Geoffray, Marion Leboyer, Angela Sirigu
Oxytocin (OT), a neuropeptide involved in affiliation has been shown to enhance social skills in patients with autism spectrum disorders (ASD). Nevertheless, OT improvements seem ephemeral. Animal research has demonstrated OT action on serotonin (5-HT), an interaction that we also found in the healthy human brain. Whether such synaptic interplay also occurs in ASD patients is unknown. To address this issue, we mapped the effects of intranasal OT on 5-HT in 18 patients with ASD and 24 healthy controls (HC) in a double blind, placebo controlled, within subject PET-scan experiment...
October 17, 2017: Cerebral Cortex
Christoph Schwarz, Fabian Fitschek, David Bar-Or, Daniel A Klaus, Bianca Tudor, Edith Fleischmann, Georg Roth, Dietmar Tamandl, Thomas Wekerle, Michael Gnant, Martin Bodingbauer, Klaus Kaczirek
BACKGROUND: Postoperative complications are still a major concern after liver resection (LR). Systemic inflammation and deregulated reactive oxygen species during major abdominal surgery may impair outcome after hepatectomy. METHODS: Patients undergoing LR were included in this study (n = 40). Oxidative stress (OS) was measured peri- and post-operatively as static oxidation-reduction potential markers (sORP) and antioxidant capacity ORP (cORP) by using the RedoxSYS Diagnostic system...
2017: PloS One
Robert G Lockie, Matthew R Moreno, Ashley J Orjalo, Adrina Lazar, Tricia M Liu, Alyssa A Stage, Samantha A Birmingham-Babauta, John J Stokes, Dominic V Giuliano, Fabrice G Risso, DeShaun L Davis, Samuel J Callaghan
The study investigated relationships between arm (AL) and leg length (LL) and conventional deadlift (CD) and high-handle hexagonal bar deadlift (HHBD) mechanics. Twenty-three resistance-trained subjects (14 males, 9 females) completed a one-repetition maximum (1RM) CD and HHBD. A linear position transducer was used to measure: lift distance and duration; peak and mean power, velocity, and force; time to peak power and velocity; and work. Right AL and LL were measured, and AL-to-LL ratio (AL:LL) was also calculated...
October 16, 2017: Journal of Strength and Conditioning Research
Christian Bär, Thomas Thum
No abstract text is available yet for this article.
October 17, 2017: European Journal of Heart Failure
Pooja Viswanathan, Andreas Nieder
The concept of receptive field (RF) describes the responsiveness of neurons to sensory space. Neurons in the primate association cortices have long been known to be spatially selective but a detailed characterization and direct comparison of RFs between frontal and parietal association cortices is missing. We sampled the RFs of a large number of neurons from two interconnected areas of the frontal and parietal lobes, the dorsolateral prefrontal cortex (dlPFC) and ventral intraparietal area (VIP), of rhesus monkeys by systematically presenting a moving bar during passive fixation...
October 17, 2017: European Journal of Neuroscience
Robin M Bär, Stefan Kirschner, Martin Nieger, Stefan Bräse
Herein we report the addition of different thiols to the strained carbon-carbon bond of [1.1.1]propellane (1). We investigated the reaction pathway, performed the addition with substituted thiols, hydrogen sulfide and protected cysteine and verified further modifications of the products. The clean reaction proceeds probably through a radical chain process as we confirmed with different deuterium labelling experiments. It shows great functional group tolerance as halogen-, hydroxy-, methoxy-, carboxy-, amino- and nitro-substituted thiols could be added to 1 with few by-products in 16-90% yield...
October 16, 2017: Chemistry: a European Journal
Yaozu Liao, Zhonghua Cheng, Weiwei Zuo, Arne Thomas, Charl F J Faul
Nitrogen-rich conjugated microporous polymers (NCMPs) have attracted great attention in recent years owing to their polarity, basicity, and ability to coordinate metal ions. Herein three NCMPs, structurally close to polyaniline, were facilely synthesized via chemical oxidative polymerization between multi-connected aniline precursors. The NCMPs with high N content (11.84 wt%), intrinsic ultramicroporosity (<1 nm) and moderate surface area (485 m2 g-1), show wide-ranging adsorption functionality, e.g. CO2 uptake (11 wt%) and CO2-selectivity over N2 (360, 1 bar), 1...
October 18, 2017: ACS Applied Materials & Interfaces
Nasreen Mahomed, Nicholas Fancourt, John de Campo, Margaret de Campo, Aliu Akano, Thomas Cherian, Olivia G Cohen, David Greenberg, Stephen Lacey, Neera Kohli, Henrique M Lederman, Shabir A Madhi, Veronica Manduku, Eric D McCollum, Kate Park, Jose Luis Ribo-Aristizabal, Naor Bar-Zeev, Katherine L O'Brien, Kim Mulholland
Childhood pneumonia is among the leading infectious causes of mortality in children younger than 5 years of age globally. Streptococcus pneumoniae (pneumococcus) is the leading infectious cause of childhood bacterial pneumonia. The diagnosis of childhood pneumonia remains a critical epidemiological task for monitoring vaccine and treatment program effectiveness. The chest radiograph remains the most readily available and common imaging modality to assess childhood pneumonia. In 1997, the World Health Organization Radiology Working Group was established to provide a consensus method for the standardized definition for the interpretation of pediatric frontal chest radiographs, for use in bacterial vaccine efficacy trials in children...
October 2017: Pediatric Radiology
A Alan Moghissi, Lisa M Jaeger, Dania Shafei, Lindsey L Bloom
This paper provides an overview of the evolution of food labeling in the USA. It briefly describes the three phases of agricultural development consisting of naturally occurring, cross-bred, and genetically engineered, edited or modified crops, otherwise known as Genetically Modified Organisms (GMO). It uses the Best Available Regulatory Science (BARS) and Metrics for Evaluation of Regulatory Science Claims (MERSC) to evaluate the scientific validity of claims applicable to GMO and the Best Available Public Information (BAPI) to evaluate the pronouncements by public media and others...
October 17, 2017: Critical Reviews in Biotechnology
Yubin Chen, Zefeng Wang, Zhixian Li, Wei Huang, Xiaoming Xi, Qisheng Lu
We report on what is, to the best of our knowledge, the first ultra-efficient 1.5 μm Raman amplifier in a methane-filled anti-resonance hollow-core fiber. A 1.5 μm single frequency seed laser is coupled into the hollow-core fiber together with a 1064 nm pulsed pump laser using a shortpass dichromic mirror, and then amplified by stimulated Raman scattering of methane. A maximum optical-to-optical conversion efficiency of 66.4% has been obtained, resulting in a record near quantum-limit efficiency of 96.3% in a 2 m long hollow-core fiber filled with only 2 bar methane gas...
August 21, 2017: Optics Express
Hao Jia, Ting Zhou, Lei Zhang, Jianfeng Ding, Xin Fu, Lin Yang
We propose a 2 × 2 multimode optical switch, which is composed of two mode de-multiplexers, n 2 × 2 single-mode optical switches where n is the number of the supported spatial modes, and two mode multiplexers. As a proof of concept, asymmetric directional couplers are employed to construct the mode multiplexers and de-multiplexers, balanced Mach-Zehnder interferometer is utilized to construct the 2 × 2 single-mode optical switches. The fabricated silicon 2 × 2 multimode optical switch has a broad optical bandwidth and can support four spatial modes...
August 21, 2017: Optics Express
Daniel Frings, Antony C Moss, Ian P Albery, Guleser Eskisan, Thomas D W Wilcockson, Alexander P Marchant
Aims: Responsible drinking messages (RDMs) are used as a key tool to reduce alcohol-related harms. A common form of RDM is in a poster format displayed in places such as bars, bus stops and toilet cubicles. However, evidence for the effectiveness of RDMs remains limited. Moreover, it is not known how environmental contexts (e.g. the number of alcohol-related cues in the environment) impact how such RDMs are interacted with, nor how this in turn affects their efficacy. Methods: One hundred participants completed a pseudo taste preference task in either in a bar laboratory (alcohol cue rich environmental context) or a traditional laboratory...
October 13, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
C H Lasecki, F C Mujica, S Stutsman, A Y Williams, L Ding, J D Simmons, S B Brevard
BACKGROUND: Geographic information systems (GIS) have proven effective in studying intentional injury in various communities; however, GIS is not implemented widely for use by level I trauma centers in understanding patient populations. Our study of intentional injury combines the capabilities of GIS with a level I trauma center registry to determine the spatial distribution of victims and correlated socioeconomic factors. METHODS: 1,099 out of 3,109 total incidents of intentional trauma in the trauma registry from 2005-2015 had sufficient street address information to be mapped in GIS...
October 16, 2017: Journal of Trauma and Acute Care Surgery
Shirly Bar-Lev, Dizza Beimel
No abstract text is available yet for this article.
2017: Studies in Health Technology and Informatics
Zachary R Hanna, James B Henderson, Anna B Sellas, Jérôme Fuchs, Rauri C K Bowie, John P Dumbacher
We report here the successful assembly of the complete mitochondrial genomes of the northern spotted owl (Strix occidentalis caurina) and the barred owl (S. varia). We utilized sequence data from two sequencing methodologies, Illumina paired-end sequence data with insert lengths ranging from approximately 250 nucleotides (nt) to 9,600 nt and read lengths from 100-375 nt and Sanger-derived sequences. We employed multiple assemblers and alignment methods to generate the final assemblies. The circular genomes of S...
2017: PeerJ
Xueqiang Zeng, Gang Luo
PURPOSE: Machine learning is broadly used for clinical data analysis. Before training a model, a machine learning algorithm must be selected. Also, the values of one or more model parameters termed hyper-parameters must be set. Selecting algorithms and hyper-parameter values requires advanced machine learning knowledge and many labor-intensive manual iterations. To lower the bar to machine learning, miscellaneous automatic selection methods for algorithms and/or hyper-parameter values have been proposed...
December 2017: Health Information Science and Systems
Anshul Rai
The palatal fracture is rare. There are varieties of techniques mentioned in the literature for fixation of palatal fracture. The management with Kirschner wire fixation, maxillary arch stabilization with the arch bars, trans-palatal, intra osseous, inter-molar, figure of eight wiring were technique sensitive and having poor patient compliance. We recommended the use of isolated 3 dimensional plate for fixation of sagittal palatal fracture.
December 2017: Journal of Maxillofacial and Oral Surgery
M Sherif El-Eskandarany, Ehab Shaban, Fahad Aldakheel, Abdullah Alkandary, Montaha Behbehani, M Al-Saidi
Storing hydrogen gas into cylinders under high pressure of 350 bar is not safe and still needs many intensive studies dedic ated for tank's manufacturing. Liquid hydrogen faces also severe practical difficulties due to its very low density, leading to larger fuel tanks three times larger than traditional gasoline tank. Moreover, converting hydrogen gas into liquid phase is not an economic process since it consumes high energy needed to cool down the gas temperature to -252.8 °C. One practical solution is storing hydrogen gas in metal lattice such as Mg powder and its nanocomposites in the form of MgH2...
October 16, 2017: Scientific Reports
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