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https://www.readbyqxmd.com/read/27906363/construction-of-the-optical-part-of-a-time-of-flight-detector-prototype-for-the-afp-detector
#1
L Nozka, L Adamczyk, G Avoni, A Brandt, P Buglewicz, E Cavallaro, G Chiodini, L Chytka, K Ciesla, P M Davis, M Dyndal, S Grinstein, P Hamal, M Hrabovsky, K Janas, K Jirakova, M Kocian, T Komarek, K Korcyl, J Lange, D Mandat, V Michalek, I Lopez Paz, D Northacker, M Rijssenbeek, L Seabra, P Schovanek, R Staszewski, P Swierska, T Sykora
We present the construction of the optical part of the ToF (time-of-flight) subdetector prototype for the AFP (ATLAS Forward Proton) detector. The ToF detector in conjunction with a 3D silicon pixel tracker will tag and measure protons originating in central exclusive interactions p + p → p + X + p, where the two outgoing protons are scattered in the very forward directions. The ToF is required to reduce so-called pileup backgrounds that arise from multiple proton interactions in the same bunch crossing at high luminosity...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906212/influence-of-co-sub-2-sub-pressure-on-the-emission-spectra-and-plasma-parameters-in-underwater-laser-induced-breakdown-spectroscopy
#2
Christian L Goueguel, Dustin L McIntyre, Jinesh C Jain
Optical emission spectroscopic studies have been carried out to investigate the pressure effect of CO<sub>2</sub> on laser-produced underwater plasma. The plasma was generated by focusing 1064 nm, 6 ns pulses from a Nd:YAG laser in a CO<sub>2</sub>-bearing solution. The temporal evolution of the continuum emission, Sr and Ba lines, and plasma electron density and temperature was characterized under CO<sub>2</sub> pressure ranging from 10 to 300 bars. The electron density measurements were made using the Stark broadening of the 455...
December 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27906169/automated-identification-of-mouse-visual-areas-with-intrinsic-signal-imaging
#3
Ashley L Juavinett, Ian Nauhaus, Marina E Garrett, Jun Zhuang, Edward M Callaway
Intrinsic signal optical imaging (ISI) is a rapid and noninvasive method for observing brain activity in vivo over a large area of the cortex. Here we describe our protocol for mapping retinotopy to identify mouse visual cortical areas using ISI. First, surgery is performed to attach a head frame to the mouse skull (∼1 h). The next day, intrinsic activity across the visual cortex is recorded during the presentation of a full-field drifting bar in the horizontal and vertical directions (∼2 h). Horizontal and vertical retinotopic maps are generated by analyzing the response of each pixel during the period of the stimulus...
January 2017: Nature Protocols
https://www.readbyqxmd.com/read/27905592/the-conformational-landscape-of-2-4-fluoro-phenyl-ethylamine-consequences-of-fluorine-substitution-at-the-para-position
#4
Afik Shachar, Nitzan Mayorkas, Hanan Sachs, Ilana Bar
Fluorination is considered as a possible means for alteration of conformational landscapes in molecules. The effect of fluorine substitution was studied here by measuring the vibronic and vibrational spectra of gas phase 2-(4-fluoro-phenyl)-ethylamine (4-FPEA) by resonant two-photon ionization (R2PI) and by ionization-loss stimulated Raman spectroscopy (ILSRS). The measurement of survey ILSR spectra of 4-FPEA in the amino group region allowed to associate the bands in the R2PI spectrum to origin and vibronic transitions of the ground (S0) to the excited (S1) electronic states of three different conformers...
December 1, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27904094/design-and-synthesis-of-functional-molecules-based-on-complexation-and-their-biological-applications
#5
Yosuke Hisamatsu
 In this review, we introduce the development of supermolecules, host-guest complexes, and metal complexes formed from the combination of non-covalent interactions and/or coordination bonds, as well as their biological applications. An adenine selective host molecule 1 provides a correctly oriented array of complementary hydrogen bonding sites for the adenine nucleobase. Furthermore, the new DDAA (D: hydrogen bond donor, A: hydrogen bond acceptor) module 4 and ADDA module 7 have been developed as quadruple hydrogen-bonding modules...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27904090/effect-of-bidirectional-loading-on-contact-and-force-characteristics-under-a-newly-developed-masticatory-simulator-with-a-dual-direction-loading-system
#6
Weerachai Singhatanadgit, Puttiporn Junkaew, Pairod Singhatanadgid
Mechanical responses of the test specimen under bidirectional and unidirectional loading were investigated using a newly developed masticatory simulator. The simulator adopted a four-bar linkage mechanism to create both loading patterns. Scratch/occlusal contact characteristics, contact force profiles and the fracture of restored tooth samples were investigated. With bidirectional loading, which imitates the nature of human chewing cycle closer than the unidirectional loading does, the occlusal contact was ovoid in shape whereas a small circular area was observed from the test with unidirectional loading...
2016: Dental Materials Journal
https://www.readbyqxmd.com/read/27903707/formation-of-long-term-locomotor-memories-is-associated-with-functional-connectivity-changes-in-the-cerebellar-thalamic-cortical-network
#7
Firas Mawase, Simona Bar-Haim, Lior Shmuelof
: Although motor adaptation is typically rapid, accumulating evidence shows that it is also associated with long-lasting behavioural and neuronal changes. Two processes were suggested to explain the formation of long-term motor memories: recall -- reflecting a retrieval of previous motor actions, and faster relearning -- reflecting an increased sensitivity to errors. While these manifestations of motor memories were initially demonstrated in the context of adaptation experiments in reaching, indications of long-term motor memories were also recently demonstrated in other kinds of adaptation, such as in locomotor adaptation...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27903554/a-new-microextraction-technique-for-the-assay-of-alkaloids-in-chinese-compound-formula-based-polyether-sulfone-membrane-fiber-decorated-by-tio2-nanoparticles
#8
Xinjie Sun, Yingqin Wei, Baojuan Hou, Guowei Zhou
A new nanocomposite membrane was used to clean up impurities from complex samples and the obvious synergy was obtained in this paper. The nanocomposite membrane was prepared by dispersing TiO2 nanoparticles in chloroform and filled in the pores and lumen of polyether sulfone membrane fiber. The novel microextraction method showed the ideal selective extraction effect for alkaloids in the formulae composed of Rhizoma coptidis and the excellent clean-up efficiency compared with the single membrane method. The optimum extraction conditions were as follows: chloroform as accepted phase; the number of nanocomposite membrane fiber bars, 7; extraction time, 30 min; pH of the sample solution, 10...
November 29, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27903141/does-the-second-amendment-protect-the-gun-rights-of-persons-with-mental-illness
#9
Paul S Appelbaum
Under federal law, persons who have been involuntarily hospitalized for psychiatric reasons are permanently barred from gun possession. That policy was challenged in 2012 by a Michigan man who had been committed 25 years earlier and who was blocked in 2011 from buying a gun. Considering his claim, the Sixth Circuit held that people with mental illness are not categorically excluded from Second Amendment protection and that an irreversible lifetime ban was unconstitutional. Although many mental health organizations and practitioners favor gun restrictions, they oppose discriminatory treatment of persons with mental illness, creating ambivalence about the decision, which presages greater involvement of mental health professionals in decisions regarding gun rights restoration...
December 1, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27900391/erratum-to-protease-activated-receptor-2-affects-protease-activated-receptor-1-driven-breast-cancer
#10
Mohammad Jaber, Miriam Maoz, Arun Kancharla, Daniel Agranovich, Tamar Peretz, Sorina Grisaru-Granovsky, Beatrice Uziely, Rachel Bar-Shavit
No abstract text is available yet for this article.
November 30, 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27900194/chair-based-fidgeting-and-energy-expenditure
#11
Gabriel A Koepp, Graham K Moore, James A Levine
INTRODUCTION: Sedentariness is associated with chronic health conditions, impaired cognitive function and obesity. Work contributes significantly to sedentariness because many work tasks necessitate sitting. Few sustained solutions exist to reverse workplace sedentariness. Here, we evaluated a chair and an under-table device that were designed to promote fidgeting while seated. Our hypothesis was that an under-table leg-fidget bar and/or a fidget-promoting chair significantly increased energy expenditure...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27900147/complex-shoulder-girdle-injuries-following-mountain-bike-accidents-and-a-review-of-the-literature
#12
Matthew Alexander Lea, Navnit Makaram, Makaram S Srinivasan
BACKGROUND: Mountain and road bike accidents are particularly common with the increased popularity of the sport. We reviewed the attendances in our emergency department over a 4-year period looking at cycling injuries to detect the level and grade of these injuries and their outcomes. METHOD: Royal Blackburn Hospital caters for a population of 550 000. A search through the Hospital information system revealed 104 patients with fractures following mountain bike injuries...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27898700/sbg1-is-a-novel-regulator-for-the-localization-of-the-%C3%AE-glucan-synthase-bgs1-in-fission-yeast
#13
Reshma Davidson, Josef A Pontasch, Jian-Qiu Wu
Glucan synthases synthesize glucans, complex polysaccharides that are the major components in fungal cell walls and division septa. Studying regulation of glucan synthases is important as they are essential for fungal cell survival and thus popular targets for anti-fungal drugs. Linear 1,3-β-glucan is the main component of primary septum and is synthesized by the conserved β-glucan synthase Bgs1 in fission yeast cytokinesis. It is known that Rho1 GTPase regulates Bgs1 catalytic activity and the F-BAR protein Cdc15 plays a role in Bgs1 delivery to the plasma membrane...
2016: PloS One
https://www.readbyqxmd.com/read/27898422/national-evidence-in-israel-supporting-reevaluation-of-respiratory-syncytial-virus-prophylactic-guidelines
#14
Itai Gross, Yael Siedner-Weintraub, Wiessam Abu Ahmad, Benjamin Bar-Oz, Smadar Eventov-Friedman
BACKGROUND: The American Academy of Pediatrics (AAP) recently narrowed the indications for respiratory syncytial virus (RSV) prophylaxis, while in Israel the guidelines have not changed. OBJECTIVE: To compare the prevalence and severity of RSV infection among preterm infants born earlier than 340/7 weeks of gestation (PI), late preterm infants born at 340/7-366/7 weeks (LPTI), and term infants born after 370/7 weeks of gestation (TI) and to determine whether the results support a change in local policy...
November 30, 2016: Neonatology
https://www.readbyqxmd.com/read/27896859/paraneoplastic-pityriasis-rubra-pilaris-case-report-and-literature-review
#15
E Bar-Ilan, A Gat, E Sprecher, T Zeeli
Pityriasis rubra pilaris (PRP; MIM 173200) is an uncommon papulosquamous inflammatory dermatosis. Only a few cases of PRP associated with an underlying malignancy have been documented. We investigated a 59-year-old patient presenting with a fulminant form of PRP recalcitrant to systemic retinoid therapy, in whom the skin disease heralded a diagnosis of cholangiocarcinoma. We searched the MEDLINE database to find articles reporting on similar associations of PRP with malignancies. We identified 10 studies linking PRP and malignancies, but an association between PRP and cholangiocarcinoma has not yet been reported...
November 29, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27893479/complex-training-the-effect-of-exercise-selection-and-training-status-on-post-activation-potentiation-in-rugby-league-players
#16
David J Scott, Massimiliano Ditroilo, Phil Marshall
This study compared the post-activation potentiation (PAP) response of the hex bar deadlift (HBD) and back squat (BS) exercises. The PAP response between different levels of athletes was also compared. Ten professional and ten amateur rugby league players performed two experimental sessions. Participants performed a countermovement jump (CMJ) before and 2, 4, 6, 8, 10, 12, 14 and 16 minutes after a conditioning activity (CA) that contained 1 set of 3 repetitions at 93% 1RM of either HBD or BS. A force platform determined peak power output (PPO), force at PPO, velocity at PPO and jump height of each CMJ...
November 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27893476/comparison-of-muscle-involvement-and-posture-between-the-conventional-deadlift-and-a-walk-in-style-deadlift-machine
#17
Benjamin J Snyder, Courtney P Cauthen, Scott R Senger
The deadlift exercise is one of the most effective exercises for developing lower-body strength; however, technique errors can lead to low back injuries. The use of a 'walk-in' deadlift machine removes the weight bar by using a lever system with independent handles on either side of the body. Theoretically, this would allow alignment of the load with the center of gravity, encouraging a more upright torso and decreasing the involvement of the low back extensors. This study compared trunk angle, knee angle and electrical activity of key muscles between the conventional deadlift (CDL) and two foot positions (ball of foot or toe alignment) with pronated grip, (called BallPro and ToePro) of a walk-in deadlift machine among high-skilled and low-skilled lifters...
November 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27890532/what-governs-successful-performance-of-a-complex-whole-body-movement-the-kovacs-release-regrasp-on-horizontal-bar
#18
Michael J Hiley, Maurice R Yeadon
The Kovacs is a release and regrasp skill performed on the horizontal bar in men׳s artistic gymnastics. It is a popular skill in elite competitive gymnastics with over 40% of male gymnasts performing a variation of the Kovacs at the London 2012 Olympics. In the qualifying competition 84% of Kovacs were successfully regrasped, with the remaining 16% resulting in a fall. The aim of the present study was to determine why some gymnasts are more successful than others at regrasping the bar, with a secondary aim to determine how a less successful gymnast could alter his technique in order to become more successful...
November 16, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27890326/the-effect-of-metabolic-comorbidities-and-commonly-used-drugs-on-the-prognosis-of-patients-with-ovarian-cancer
#19
Daniel Bar, Ofer Lavie, Nili Stein, Ido Feferkorn, Ayelet Shai
BACKGROUND: Diabetes mellitus is associated with an increased risk of recurrence in patients with ovarian cancer. Retrospective studies suggested that the use of statins, metformin and beta blockers is associated with improved prognosis in these patients. Patients with diabetes often suffer from hypertension and are usually treated concomitantly by several classes of drugs. Our aim was to assess the independent contribution of diabetes mellitus and hypertension and of the use of aspirin, statins, metformin and beta blockers on the risk of ovarian cancer recurrence and mortality...
October 14, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27889896/decreased-anxiety-related-behaviour-but-apparently-unperturbed-numb-function-in-ligand-of-numb-protein-x-lnx-1-2-double-knockout-mice
#20
Joan A Lenihan, Orthis Saha, Victoria Heimer-McGinn, John F Cryan, Guoping Feng, Paul W Young
NUMB is a key regulator of neurogenesis and neuronal differentiation that can be ubiquitinated and targeted for proteasomal degradation by ligand of numb protein-X (LNX) family E3 ubiquitin ligases. However, our understanding of LNX protein function in vivo is very limited. To examine the role of LNX proteins in regulating NUMB function in vivo, we generated mice lacking both LNX1 and LNX2 expression in the brain. Surprisingly, these mice are healthy, exhibit unaltered levels of NUMB protein and do not display any neuroanatomical defects indicative of aberrant NUMB function...
November 26, 2016: Molecular Neurobiology
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