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https://www.readbyqxmd.com/read/29474677/review-of-autophagy-related-approaches-for-improving-nutrient-use-efficiency-and-crop-yield-protection
#1
Tamar Avin-Wittenberg, Frantisek Baluška, Peter V Bozhkov, Pernilla H Elander, Alisdair R Fernie, Gad Galili, Ammar Hassan, Daniel Hofius, Erika Isono, Romain Le Bars, Céline Masclaux-Daubresse, Elena A Minina, Hadas Peled-Zehavi, Núria S Coll, Luisa M Sandalio, Béatrice Satiat-Jeunemaitre, Agnieszka Sirko, Pilar S Testillano, Henri Batoko
Autophagy is a eukaryotic catabolic pathway essential for growth and development. In plants, it is activated in response to environmental cues or developmental stimuli. However, in contrast to other eukaryotic systems, we know relatively little regarding the molecular players involved in autophagy and the regulation of this complex pathway. In the framework of the COST (European Cooperation in Science and Technology) action TRANSAUTOPHAGY (2016-2020), we decided to review our current knowledge of autophagy responses in higher plants, with emphasis on knowledge gaps...
February 21, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29473467/checkpoint-inhibitors-raising-the-bar-also-in-brain-metastases-from-non-small-cell-lung-cancer
#2
Sabrina Rossi, Giovanna Finocchiaro, Silvia Marchetti, Luca Toschi, Armando Santoro
Despite efforts, brain metastases (BM) remain a critical issue in the management of patients affected by non-small-cell lung cancer (NSCLC). To date, radiotherapy is still considered the gold standard treatment; on the other hand, systemic chemotherapeutical agents are not so often an effective therapy for BM, whereas targeted agents in oncogene-addicted disease have shown a good activity also on BM. Anti-programmed death-1/programmed death ligand-1 agents represent a new valid therapeutic strategy for NSCLC as well as for several tumor types, but their efficacy on patients with BM is still unclear mainly due to the strict selection criteria adopted in clinical trials...
April 2018: Immunotherapy
https://www.readbyqxmd.com/read/29473018/a-global-analysis-of-kinase-function-in-candida-albicans-hyphal-morphogenesis-reveals-a-role-for-the-endocytosis-regulator-akl1
#3
Hagit Bar-Yosef, Tsvia Gildor, Bernardo Ramírez-Zavala, Christian Schmauch, Ziva Weissman, Mariel Pinsky, Rawi Naddaf, Joachim Morschhäuser, Robert A Arkowitz, Daniel Kornitzer
The human pathogenic fungus Candida albicans can switch between yeast and hyphal morphologies as a function of environmental conditions and cellular physiology. The yeast-to-hyphae morphogenetic switch is activated by well-established, kinase-based signal transduction pathways that are induced by extracellular stimuli. In order to identify possible inhibitory pathways of the yeast-to-hyphae transition, we interrogated a collection of C. albicans protein kinases and phosphatases ectopically expressed under the regulation of the TETon promoter...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29473012/nuss-procedure-for-a-patient-with-negative-haller-index
#4
Mariela Dore, Paloma Triana Junco, Carlos De La Torre, Alejandra Vilanova-Sánchez, Monserrat Bret, Gaspar Gonzalez, Vanesa Nuñez Cerezo, Javier Jimenez Gomez, Jose Luis Encinas, Francisco Hernandez, Leopoldo Martínez Martínez, Manuel Lopez Santamaria
Introduction  Minimally invasive repair for pectus excavatum (MIRPE) is controversial in extremely severe cases of pectus excavatum (PE) and an open repair is usually favored. Our aim is to describe a case of a patient with an extremely severe PE that underwent a minimally invasive approach. Case report  An 8-year-old girl with severe sternum depression was assessed. She had a history of exercise intolerance, nocturnal dyspnea, fatigue, and shortness of breath. Chest computed tomography showed that sternum depression was posterior to the anterior vertebral column; therefore, Haller and correction index could not be measured...
January 2018: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/29472761/more-new-deep-reef-basslets-teleostei-grammatidae-lipogramma-with-updates-on-the-eco-evolutionary-relationships-within-the-genus
#5
Carole C Baldwin, Luke Tornabene, D Ross Robertson, Ai Nonaka, R Grant Gilmore
Two new Lipogramma basslets are described, L. barrettorum and L. schrieri , captured during submersible diving to 300 m depth off Curaçao, southern Caribbean. Superficially resembling L. robinsi in having 11-12 bars of pigment on the trunk, L. barrettorum is distinct from L. robinsi in having a stripe of blue-white pigment along the dorsal midline of the head (vs. a cap of yellow pigment), in patterns of pigment on the median fins, and in having 8-10 gill rakers on the lower limb of the first arch (vs. 11-12)...
2018: ZooKeys
https://www.readbyqxmd.com/read/29472570/the-po-delta-is-restarting-progradation-geomorphological-evolution-based-on-a-47-years-earth-observation-dataset
#6
A Ninfo, P Ciavola, P Billi
From the 1950s, the Po delta, one of the largest anthropogenic world deltas, has been subjected to a fast degradation and shoreline retreat due a marked reduction of sediment supply, mainly controlled by human impacts/factors, including subsidence. Through the interpretation of satellite images, coupled with the analysis of the flow discharge, and of the annual frequency of marine storms, we show that recently (>2010) the Po River has resumed delta progradation, especially in its northern portion. This happens after decades of erosion, followed by alternating regrowth and degradation phases, indicating conditions of substantial stability (1970-2000)...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29471810/expression-and-function-of-microrna-9-in-the-mid-hindbrain-area-of-embryonic-chick
#7
A Alwin Prem Anand, Carola Huber, John Asnet Mary, Nancy Gallus, Christoph Leucht, Ruth Klafke, Bernhard Hirt, Andrea Wizenmann
BACKGROUND: MiR-9 is a small non-coding RNA that is highly conserved between species and primarily expressed in the central nervous system (CNS). It is known to influence proliferation and neuronal differentiation in the brain and spinal cord of different vertebrates. Different studies have pointed to regional and species-specific differences in the response of neural progenitors to miR-9. METHODS: In ovo and ex ovo electroporation was used to overexpress or reduce miR-9 followed by mRNA in situ hybridisation and immunofluorescent stainings to evaluate miR- expression and the effect of changed miR-9 expression...
February 22, 2018: BMC Developmental Biology
https://www.readbyqxmd.com/read/29471199/statistical-modelling-of-fat-oil-and-grease-fog-deposits-in-wastewater-pump-sumps
#8
Eva Nieuwenhuis, Johan Post, Alex Duinmeijer, Jeroen Langeveld, François Clemens
The accumulation of FOG (Fat, Oil and Grease) deposits in sewer pumping stations results in an increase in maintenance costs, malfunctioning of pumps and, a potential increase of wastewater spills in receiving open water bodies. It is thought that a variety of parameters (e.g. geometry of the pump sump, pump operation, socioeconomic parameters of the catchment) influences the built-up of FOG. Based on a database containing data of 126 pumping stations located in five Dutch municipalities a statistical model was built...
February 13, 2018: Water Research
https://www.readbyqxmd.com/read/29470808/comparative-analysis-of-recruitment-strategies-in-a-study-of-men-who-have-sex-with-men-msm-in-metropolitan-detroit
#9
Bradley E Iott, Tiffany C Veinot, Jimena Loveluck, Erin Kahle, Leon Golson, Akilah Benton
HIV/AIDS-related research requires recruitment of representative samples of MSM; yet, we know little about the comparative yield, diversity and cost-benefit tradeoffs between different recruitment venues. We compared 11 recruitment venues used for nine HIV prevention-related focus groups with MSM in Metropolitan Detroit. Of the 64 participants, 24 were clients recruited via an HIV/AIDS-focused nonprofit, 20 from Grindr advertisements, 6 from university-student email lists, and 5 from flyers/palmcards. Significantly more African-American, low-income and HIV-positive participants were recruited via the nonprofit...
February 22, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29470783/the-economic-foundations-of-cohabiting-couples-union-transitions
#10
Patrick Ishizuka
In recent decades, cohabitation has become an increasingly important relationship context for U.S. adults and their children, a union status characterized by high levels of instability. To understand why some cohabiting couples marry but others separate, researchers have drawn on theories emphasizing the benefits of specialization, the persistence of the male breadwinner norm, low income as a source of stress and conflict, and rising economic standards associated with marriage (the marriage bar). Because of conflicting evidence and data constraints, however, important theoretical questions remain...
February 22, 2018: Demography
https://www.readbyqxmd.com/read/29470067/tunable-robust-pacs-mofs-a-platform-for-systematic-enhancement-of-the-c-2-h-2-uptake-and-c-2-h-2-c-2-h-4-separation-performance
#11
Di-Ming Chen, Chun-Xiao Sun, Nan-Nan Zhang, Huan-Huan Si, Chun-Sen Liu, Miao Du
As a modulatable class of porous crystalline materials, metal-organic frameworks (MOFs) have gained intensive research attention in the domain of gas storage and separation. In this study, we report on the synthesis and gas adsorption properties of two robust MOFs with the general formula [Co3 (μ3 -OH)(cpt)3 Co3 (μ3 -OH)(L)3 (H2 O)9 ](NO3 )4 (guests)n [L = 3-amino-1,2,4-triazole (1) and 3,5-diamino-1,2,4-triazole (2); Hcpt = 4-(4-carboxyphenyl)-1,2,4-triazole], which show the same pacs topology. Both MOFs are isostructural to each other and show MIL-88-type frameworks whose pore spaces are partitioned by different functionlized trinuclear 1,2,4-triazolate-based clusters...
February 22, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29470059/low-pressure-nanofiltration-nf-hollow-fiber-membranes-for-effective-fractionation-of-dyes-and-inorganic-salts-in-textile-wastewater
#12
Gang Han, Tai-Shung Chung, Martin Weber, Christian Maletzko
In this work, novel loose nanofiltration (NF) hollow fiber membranes with ultrahigh water permeability and well-defined nanopore and surface charge characteristics were developed for effective fractionation of dyes and inorganic salts in textile wastewater treatment. The as-spun NF hollow fiber possesses a high pure water permeability (PWP) of 80 L.m-2.h-1.bar-1 with a small pore size of 1.0 nm in diameter and a MWCO of 1000 Da. The surface modification by means of hyperbranched polyethyleneimine (PEI) further lowers the pore diameter to 0...
February 22, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29469991/gene-expression-on-dna-biochips-patterned-with-strand-displacement-lithography
#13
Günther Pardatscher, Matthaeus Schwarz-Schilling, Shirley S Daube, Roy H Bar-Ziv, Friedrich Christian Simmel
Lithographic patterning of DNA molecules enables spatial organization of cell-free genetic circuits under well-controlled experimental conditions. Here, we present a biocompatible, DNA-based resist termed "Bephore" based on commercially available components, which can be patterned by both photo- and electron beam lithography. The patterning mechanism is based on cleavage of a chemically modified DNA hairpin by ultraviolet light or electrons, and a subsequent strand displacement reaction. All steps are performed in aqueous solution and do not require chemical development of the resist, which makes the lithographic process robust and biocompatible...
February 22, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29469829/measurement-of-multispecies-concentration-and-gas-temperature-in-an-ammonium-dinitramide-based-thruster-by-tunable-diode-lasers
#14
Hui Zeng, Fei Li, Xilong Yu, Dongbin Ou, Lianzhong Chen
In this paper, quantitative experiments were made to measure the concentration of key intermediate products (CO, N2 O, and NO) and the gas temperature for combustion flow based on near-infrared and mid-infrared laser absorption spectroscopy. This paper used the developed diagnostic system to study two main ignition modes of a real 1-Newton thruster based on ammonium dinitramide (ADN): steady-state firing and pulse-mode firing over a feed pressure of 5-12 bar. The steady-state firing experiments distinguished the whole process into catalytic decomposition stage and combustion stage, experimentally demonstrating the combustion kinetics mechanism of an ADN monopropellant...
February 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29469617/are-energy-drinks-scapegoats-decomposing-teenagers-caffeine-intake-from-energy-drinks-and-soda-beverages
#15
Ofir Turel
BACKGROUND: Energy drinks have been repeatedly blamed for contributing to caffeine intake among teenagers. OBJECTIVES: This study aimed to estimate and compare the caffeine intake of US teenagers from soda drinks versus energy drinks and shots. METHODS: Data were taken from a 2015 nationally representative survey (Monitoring the Future) of 8th and 10th graders in the US (47.2% 8th grade; 51.1% female). Participants reported their numbers of consumed sodas, diet sodas, energy drinks, and energy shots per day...
February 22, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29468627/terrorism-reports-the-tip-of-the-iceberg
#16
Eytan Ellenberg, Mark Taragin, Zvia Bar-On, Osnat Cohen, Ishay Ostfeld
IMPORTANCE: Medical impact of terror is a public health issue as the threat is growing all over the world. OBJECTIVE: Our objective was to compare the number of injured and incidents in the three different databases and reports [Global Terrorism Database (GTD), Israeli Security Agency (ISA) and National Insurance Institute (NII)] in Israel. DESIGN: Retrospective study. SETTING: Analyses of three different databases (GTD, ISA and NII) and basic comparison...
October 2017: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/29467609/phospho-tau-bar-code-analysis-of-phosphoisotypes-of-tau-and-its-application-to-tauopathy
#17
REVIEW
Taeko Kimura, Govinda Sharma, Koichi Ishiguro, Shin-Ichi Hisanaga
Tau is a microtubule-associated protein which regulates the assembly and stability of microtubules in the axons of neurons. Tau is also a major component of neurofibrillary tangles (NFTs), a pathological hallmark in Alzheimer's disease (AD). A characteristic of AD tau is hyperphosphorylation with more than 40 phosphorylation sites. Aggregates of hyperphosphorylated tau are also found in other neurodegenerative diseases which are collectively called tauopathies. Although a large number of studies have been performed on the phosphorylation of AD tau, it is not known if there is disease-specific phosphorylation among tauopathies...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29466683/mechanical-testing-of-a-steel-reinforced-epoxy-resin-bar-and-clamp-for-external-skeletal-fixation-of-long-bone-fractures-in-cats
#18
B J Leitch, A J Worth
AIMS: To provide veterinarians with confidence when using a commercially available epoxy resin in external skeletal fixators (ESF), testing was conducted to determine exothermia during curing of the epoxy resin compared to polymethylmethacrylate (PMMA); the hardness of the epoxy resin as a bar over 16 weeks, and the strength of the epoxy resin bar compared with metal clamps in similarly constructed Type 1a ESF constructs simulating the repair of feline long bone fractures. METHODS: Exothermia of the epoxy resin during curing was tested against PMMA with surface temperatures recorded over the first 15 minutes of curing, using four samples of each product...
February 21, 2018: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/29466636/-spatial-and-temporal-abundance-and-distribution-of-stomolophus-meleagris-rhizostomae-stomolophidae-in-a-lagoon-system-southern-gulf-of-mexico
#19
Francisco Javier Félix Torres, Arturo Garrido Mora, Yessenia Sánchez Alcudia, Alberto de Jesús Sánchez Martínez, Andrés Arturo Granados Berber, José Luis Ramos Palma
The scyphomedusae feed mainly on microscopic crustaceans, eggs and fish larvae, molluscs and some other jellyfishes. The distribution and abundance of the scyphomedusae has an economic and ecological impact as they are predators that have an influence on the population dynamics of other fisheries. This investigation took place in the lagoon system ‘Arrastradero-Redonda’, Tabasco, from September 2013 to August 2014, with the purpose to provide information on the distribution, and spatial and temporal abundance of Stomolophus meleagris; along with its relation to environmental parameters...
March 2017: Revista de Biología Tropical
https://www.readbyqxmd.com/read/29465599/primary-pulmonary-lymphoepithelioma-like-carcinoma-in-non-endemic-region-a-case-report-and-literature-review
#20
Chao Xie, Xia Xu, Bian Wu, Kun-Yu Yang, Jing Huang
RATIONALE: Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare type of lung squamous cell carcinoma. In situ hybridization test for Epstein-Bar virus-encoded RNA (EBER) is generally used for distinguishing it from other lung cancers. Although plasma EBV DNA quantification has been widely used as a tumor biomarker in nasopharyngeal carcinoma (NPC), only a limiting number of studies have suggested that plasma EBV DNA quantification may be used as a tumor marker in pulmonary LELC patients...
February 2018: Medicine (Baltimore)
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