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https://www.readbyqxmd.com/read/29166753/interventional-locoregional-treatment-and-metabolic-response-advantages-of-using-pet-ct-in-the-evaluation-of-response-to-treatment
#1
Monica Finessi, Marilena Bellò, Francesca P Giunta, Andrea Veltri, Désirée Deandreis
INTRODUCTION: Interventional oncology locoregional therapies are validated treatment modalities for primary and secondary tumors in liver, lung, kidney and bone. At this time, there is no accordance in the choice of imaging modality to assess treatment response. Morphological imaging and RECIST 1.1 criteria based on size variation are limited by several critical points. On the other hand the role of functional imaging, in particular by [18F]-fluorodeoxyglucose ([18F]-FDG) positron emission tomography (PET), in both staging and response evaluation of locoregional treatments remains unclear because of the heterogeneous nature of available data...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166328/18f-fdg-pet-ct-imaging-of-hidradenocarcinoma-arising-from-preexisting-hidradenoma-of-the-knee
#2
Tirth V Patel, Jorge Oldan
Malignant tumors of the sweat glands are exceedingly rare and aggressive tumors. We present here a case of a 60-year-old man with a malignant hidradenocarcinoma that developed in a background of preexisting benign hidradenoma on the lateral aspect of the knee that was initially resected, but rapidly recurred with associated inguinal lymphadenopathy. F-FDG PET/CT was performed as part of preoperative staging, which demonstrated abnormal inguinal lymph nodes and metastatic disease to the lungs. FDG PET/CT can play an invaluable role in the initial staging and follow-up of this rare malignancy...
November 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29166146/screening-for-lung-cancer-communicating-with-patients
#3
Daniel B Green, Bradley B Pua, Carolyn B Crawford, Genevieve N Abbey, Ian R Drexler, Alan C Legasto, James F Gruden
OBJECTIVE: The purposes of this article are to detail the experience of a single-center academic institution in applying the patient-centered approach to a lung cancer screening program and to examine how this approach can expand to other aspects of follow-up imaging of lung nodules. CONCLUSION: As the practice of patient-centered radiology gains attention, diagnostic radiologists are findings new ways to become more involved in patient care. A lung cancer screening program is one opportunity for radiologists to consult with and educate patients...
November 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29166136/the-gamma-aminobutyric-acid-b-receptor-gabab-encephalitis-clinical-manifestations-and-response-to-immunotherapy
#4
Junzhao Cui, Hui Bu, Junying He, Zeyan Zhao, Weixin Han, Ruiping Gao, Xiaoqing Li, Qing Li, Xiaosu Guo, Yueli Zou
PURPOSE: We report 11 patients diagnosed with GABAB receptor (GABABR) antibodies encephalitis in China and aim to analyse the clinical characteristics, laboratory and imaging findings, therapeutic modalities and outcomes. METHODS: Clinical data from patients diagnosed with anti-GABAB receptor encephalitis in the Second Affiliated Hospital of Hebei Medical University from February 2016 to October 2016 January were retrospectively collected and evaluated. RESULTS: Seven of the eleven patients were males, and a mean age at presentation of 63 years (range: 47-79 years)...
November 22, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29166129/initial-observations-of-intra-and-inter-fractional-motion-variation-in-mr-guided-lung-sbrt
#5
David H Thomas, Anand Santhanam, Amar U Kishan, Minsong Cao, James Lamb, Yugang Min, Dylan O'Connell, Yingli Yang, Nzhde Agazaryan, Percy Lee, Daniel Low
OBJECTIVE: To evaluate variations in intra- and inter-fractional tumor motion, and the effect on ITV contour accuracy, using deformable image registration of real-time 2D-sagital cine-mode MRI acquired during lung SBRT treatments. METHODS: Five lung tumor patients underwent free breathing SBRT treatments on the ViewRay system, with dose prescribed to a planning target volume (PTV; defined as a 3-6 mm expansion of the 4DCT-ITV). Sagittal slice cine-MR images (3.5x3...
November 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29163342/novel-anterior-brainstem-magnetic-resonance-imaging-findings-in-non-small-cell-lung-cancer-with-leptomeningeal-carcinomatosis
#6
Chun-Yu Cheng, Chia-Yu Hsu, Yuan-Hsiung Tsai, Kuang-Lin Lin, Cih-En Huang, Yi-Hong Fan, Shy-Chyi Chin, Yen-Chu Huang
Leptomeningeal carcinomatosis (LC) is found in around 4% of patients with non-small cell lung cancer (NSCLC). The most common radiological finding of LC is diffuse leptomeningeal enhancement on contrast-enhanced brain magnetic resonance imaging (MRI). Herein, we report a novel brain MRI finding-non-enhanced, band-like, symmetric restricted diffusion along the anterior surface of the brainstem-of LC in four patients with NSCLC. We also identified three additional cases with similar MRI findings in a literature review...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29162036/sorafenib-treatment-for-papillary-thyroid-carcinoma-with-diffuse-lung-metastases-in-a-child-with-autism-spectrum-disorder-a-case-report
#7
Yousuke Higuchi, Takayuki Motoki, Hisashi Ishida, Kiichiro Kanamitsu, Kana Washio, Takanori Oyama, Takuo Noda, Yasuko Tsurumaru, Ayumi Okada, Hirokazu Tsukahara, Akira Shimada
BACKGROUND: Pediatric papillary thyroid carcinoma frequently presents with lymph node involvement and distant metastases. Sorafenib, an oral multikinase inhibitor, has been used to treat radioactive iodine (RAI) therapy-refractory thyroid carcinoma in adults; however, pediatric experience is limited. Medical procedures and hospitalization for children with autism spectrum disorder may be challenging. CASE PRESENTATION: An 11-year-old boy with autism spectrum disorder and moderate intellectual impairment presented with dyspnea on exertion with thyroid carcinoma and diffuses lung metastases...
November 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29161579/correlation-between-lung-perfusion-blood-volume-and-spect-images-in-patients-with-chronic-thromboembolic-pulmonary-hypertension-by-balloon-pulmonary-angioplasty
#8
Hirofumi Koike, Eijun Sueyoshi, Ichiro Sakamoto, Masataka Uetani, Tomoo Nakata, Kouji Maemura
OBJECTIVES: We evaluated the reperfusion by balloon pulmonary angioplasty (BPA) in lung PBV and SPECT images. METHODS: In total, 17 patients and 57 sessions were evaluated. Pre-BPA and post-BPA lung PBV and SPECT/CT images, based on both anatomical segments and physiologic regions (upper/middle/lower) were compared. RESULTS: BPA had a positive effect on most hypoperfused/unperfused segments/regions. There was generally a high rate of agreement between PBV measurements and SPECT/CT...
November 11, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29160020/comparison-of-quantitative-regional-ventilation-weighted-fourier-decomposition-mri-with-dynamic-fluorinated-gas-washout-mri-and-lung-function-testing-in-copd-patients
#9
Till F Kaireit, Marcel Gutberlet, Andreas Voskrebenzev, Julia Freise, Tobias Welte, Jens M Hohlfeld, Frank Wacker, Jens Vogel-Claussen
BACKGROUND: Ventilation-weighted Fourier decomposition-MRI (FD-MRI) has matured as a reliable technique for quantitative measures of regional lung ventilation in recent years, but has yet not been validated in COPD patients. PURPOSE/HYPOTHESIS: To compare regional fractional lung ventilation obtained by ventilation-weighted FD-MRI with dynamic fluorinated gas washout MRI ((19) F-MRI) and lung function test parameters. STUDY TYPE: Prospective study...
November 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29159957/evaluating-performance-of-a-user-trained-mr-lung-tumor-autocontouring-algorithm-in-the-context-of-intra-and-inter-observer-variations
#10
Eugene Yip, Jihyun Yun, Zsolt Gabos, Sarah Baker, Don Yee, Keith Wachowicz, Satyapal Rathee, B Gino Fallone
PURPOSE: Real-time tracking of lung tumors using magnetic resonance imaging (MRI) has been proposed as a potential strategy to mitigate the ill-effects of breathing motion in radiation therapy. Several autocontouring methods have been evaluated against a "gold standard" of a single human expert user. However, contours drawn by experts have inherent intra- and inter-observer variations. In this study, we aim to evaluate our user-trained autocontouring algorithm with manually drawn contours from multiple expert users, and to contextualize the accuracy of these autocontours within intra- and inter- observer variations...
November 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/29159886/radiomics-in-lung-cancer-its-time-is-here
#11
Mannudeep Kalra, Ge Wang, Colin G Orton
Of the 8.8 million deaths from cancer in 2015, per the World Health Organization, lung cancer was the most common cause of death (1.69 million). With the introduction of low-dose CT for lung cancer screening and emergence of precision medicine for often-fatal lung cancer, there is a need for deep access to critical information, i.e. radiomics, not possible with conventional subjective interpretation of CT images. Quantitative image analyses for radiomics have been applied in lung cancers to determine their spatial complexity, genomic composition, viability or aggressiveness, and responses to targeted therapies...
November 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/29159180/the-influence-of-serum-prostate-specific-antigen-on-the-accuracy-of-magnetic-resonance-imaging-targeted-biopsy-versus-saturation-biopsy-in-patients-with-previous-negative-biopsy
#12
Chao-Hsiang Chang, Hung-Chieh Chiu, Wei-Ching Lin, Tzu-Lung Ho, Han Chang, Yi-Huei Chang, Chi-Ping Huang, Hsi-Chin Wu, Chi-Rei Yang, Po-Fan Hsieh
Objective: We compared the prostate cancer (PCa) detection rates of targeted biopsy (TB) and saturation biopsy (SB) in patients with previous negative biopsy and the accuracy of TB and SB stratified by different serum prostate-specific antigen (PSA) levels. Materials and Methods: Overall 185 patients were enrolled. In the magnetic resonance imaging (MRI) group, 65 men underwent TB and SB. In the control group, 120 men underwent SB alone. The primary outcome was the difference in PCa detection rate between the MRI group and control group...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29158832/clinical-translation-and-first-in-human-use-of-44-sc-sc-psma-617-for-pet-imaging-of-metastasized-castrate-resistant-prostate-cancer
#13
Elisabeth Eppard, Ana de la Fuente, Martina Benešová, Ambreen Khawar, Ralph A Bundschuh, Florian C Gärtner, Barbara Kreppel, Klaus Kopka, Markus Essler, Frank Rösch
BACKGROUND: Various trivalent radiometals are well suited for labeling of DOTA-conjugated variants of Glu-ureido-based prostate-specific membrane antigen (PSMA) inhibitors. The DOTA-conjugate PSMA-617 has proven high potential in PSMA radioligand therapy (PSMA-RLT) of prostate cancer as well as PET imaging when labeled with lutetium-177 and gallium-68 respectively. Considering the relatively short physical half-life of gallium-68 this positron emitter precludes prolonged acquisition periods, as required for pre-therapeutic dosimetry or intraoperative applications...
2017: Theranostics
https://www.readbyqxmd.com/read/29158729/evaluation-of-deformable-image-registration-for-three-dimensional-temporal-subtraction-of-chest-computed-tomography-images
#14
Ping Yan, Yoshie Kodera, Kazuhiro Shimamoto
Purpose: To perform lung image registration for reducing misregistration artifacts on three-dimensional (3D) temporal subtraction of chest computed tomography (CT) images, in order to enhance temporal changes in lung lesions and evaluate these changes after deformable image registration (DIR). Methods: In 10 cases, mutual information (MI) lung mask affine mapping combined with cross-correlation (CC) lung diffeomorphic mapping was used to implement lung volume registration...
2017: International Journal of Biomedical Imaging
https://www.readbyqxmd.com/read/29157388/future-directions-in-pet-imaging-of-lung-cancer
#15
REVIEW
Tim Akhurst
There is an ongoing and successful effort in developing new radiopharmaceuticals that coupled with new developments in chemistry and instrumentation offers the potential of rapidly defining imaging biomarkers and theranostic paradigms. The overarching challenge remains in funding and approving such agents; the Food and Drug Administration in the United States is making efforts to improve the process, but the time to release PET agents from the regulator shackles is surely now, to bring to patients the excellence of preclinical work that has already been done...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157387/non-small-cell-lung-cancer-pet-imaging-beyond-f18-fluorodeoxyglucose
#16
REVIEW
Gang Cheng
F18 Flurodeoxyglucose (FDG) is a nonspecific PET tracer representing tumor energy metabolism, with common false-positive and false-negative findings in clinical practice. Non-small cell lung cancer is highly heterogeneous histologically, biologically, and molecularly. Novel PET tracers designed to characterize a specific aspect of tumor biology or a pathway-specific molecular target have the potential to provide noninvasive key information in tumor heterogeneity for patient stratification and in the assessment of treatment response...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157385/treatment-planning-for-radiation-therapy
#17
REVIEW
Michael MacManus, Sarah Everitt
PET scanning plays key roles in planning the management of patients with lung cancer who are candidates for curative-intent treatment with radiotherapy and has contributed to improvements in survival. (18)F-fluorodeoxyglucose-PET is the most important modality for staging, patient selection, and radiotherapy target volume definition in patients with unresectable non-small cell lung cancer. Developments include the availability of alternative tracers, such as (18)F-fluorothymidine, for imaging proliferation and a range of hypoxia imaging agents...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157383/-18-f-fluoro-2-deoxy-d-glucose-pet-computed-tomography-evaluation-of-lung-cancer-in-populations-with-high-prevalence-of-tuberculosis-and-other-granulomatous-disease
#18
REVIEW
Alexandre Niyonkuru, Khamis Hassan Bakari, Xiaoli Lan
Pulmonary tuberculosis infects one-third of world's population and is responsible for the high mortality and morbidity in developing countries. The presence of a high number of macrophages and lymphocytes in active tuberculosis granulomas is associated with high uptake of (18)F-fluoro-2-deoxy-d-glucose on PET imaging mimicking lung cancer. In many cases, radiological features of pulmonary tuberculosis are undistinguishable from lung cancer, which makes the diagnosis difficult. Clinical history and computed tomographic (CT) findings on a hybrid PET/CT are as important as findings on a PET in the diagnosis of lung cancer...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157382/diagnostic-imaging-and-newer-modalities-for-thoracic-diseases-pet-computed-tomographic-imaging-and-endobronchial-ultrasound-for-staging-and-its-implication-for-lung-cancer
#19
REVIEW
Sarah J Counts, Anthony W Kim
Modalities to detect and characterize lung cancer are generally divided into those that are invasive [endobronchial ultrasound (EBUS), esophageal ultrasound (EUS), and electromagnetic navigational bronchoscopy (ENMB)] versus noninvasive [chest radiography (CXR), computed tomography (CT), positron emission tomography (PET), and magnetic resonance imaging (MRI)]. This chapter describes these modalities, the literature supporting their use, and delineates what tests to use to best evaluate the patient with lung cancer...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157381/lung-neoplasms-with-low-f18-fluorodeoxyglucose-avidity
#20
REVIEW
Yiyan Liu
Some malignant lung neoplasms may demonstrate low or absent uptake on F18-fluorodeoxyglucose (FDG) PET/computed tomography. Pathologic type and clinical stage are independent factors associated with FDG avidity. Among lung malignancies with low FDG avidity, adenocarcinoma in situ and carcinoid are the most common. Early stage disease often has low FDG uptake. Small lesion size is another significant factor associated with negative FDG PET findings, which is due to a partial volume effect. Morphology of lung lesions on anatomic images may also affect FDG avidity...
January 2018: PET Clinics
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