spinalcord injury

Major depressive disorder (MDD) has shown to negatively impact physical recovery in a variety of medical events (e.g., stroke and spinal cord injuries). Yet depression assessments, which are typically subjective in nature, are seldom considered to develop or guide rehabilitation strategies. The present study developed a predictive depression assessment technique using functional near-infrared spectroscopy (fNIRS) that can be rapidly integrated or performed concurrently with existing physical rehabilitation tasks...

Chronic neuropathic pain is one of the primary causes of disability subsequent to spinal cord injury. Patients experiencingneuropathic pain after spinal cord injury suffer from poor quality of life, so complementary therapy is seriously needed.Dehydrocorybulbine is an alkaloid extracted from Corydalis yanhusuo. It effectively alleviates neuropathic pain. In thepresent study, we explored the effect of dehydrocorybulbine on neuropathic pain after spinal cord injury and delineated itspossible mechanism. Experiments were performed in rats to evaluate the contribution of dehydrocorybulbine to P2X4signaling in the modulation of pain-related behaviors and the levels of pronociceptive interleukins and proteins after spinalcord injury...

OBJECTIVE:Numerous studies in animals have shown the unique property of olfactory ensheathing cells tostimulate regeneration of lesioned axons in the spinal cord. In a Phase I clinical trial, weassessed the safety and feasibility of transplantation of autologous mucosal olfactoryensheathing cells and olfactory nerve fibroblasts in patients with complete spinal cord injury.METHODS:Six patients with chronic thoracic paraplegia (American Spinal Injury Association class AASIA A) were enrolled for the study. Three patients were operated and three served as acontrol group...

OBJECTIVE: The objective of this paper is to outline the proposed development process for the ICF Core Sets for Spinal Cord Injury (SCI) and to invite clinical and consumer experts to actively participate in this process. ICF Core Sets are selections of categories of the International Classification of Functioning, Disability and Health (ICF) that are relevant to persons with a specific condition or in a specific setting. METHOD: The project is a cooperation between the ICF Research Branch of the World Health Organization (WHO) Collaboration Centre of the Family of International Classifications (DIMDI, Germany), the Classification, Assessment and Terminology (CAT) team and the Disability and Rehabilitation (DAR) team at WHO, the International Spinal Cord Society (ISCoS) and International Society for Physical and Rehabilitation Medicine (ISPRM) and partner institutions across the world...

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Five young Shiloh Shepherd Dogs (4 males and 1 female) related by a common sire were studied because of progressive pelvic limb weakness and incoordination. All dogs had a spastic paraparesis and pelvic limb ataxia consistent with an upper motor neuron and general proprioceptive lesion between spinal cord segments T3 and L3. Proliferative lesions involving one or more of the articular processes from the 11th thoracic vertebrae to the 2nd lumbar vertebra were observed on radiographs of the thoracolumbar vertebrae...