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https://www.readbyqxmd.com/read/29667796/isotretinoin-the-ups-are-just-as-troubling-as-the-downs
#1
Jay M Truitt, Jason S Reichenberg, Kevin G Sharghi, Shirlene M Sampson, Randall K Roenigk, Michelle Magid
INTRODUCTION: Isotretinoin, previously marketed as Accutane®, is an oral retinoid medication that is used to treat acne and other cutaneous disorders. Although the data is conflicting, previous reports suggest a causal relationship between isotretinoin and depression. When reviewing these previous reports, many patients who were diagnosed as 'depressed' did not undergo a thorough psychiatric evaluation and/or were not diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM)...
April 18, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29667271/syndrome-and-outcome-of-antibody-negative-limbic-encephalitis
#2
Francesc Graus, Domingo Escudero, Laura Oleaga, Jordi Bruna, Alberto Villarejo-Galende, Jordi Ballabriga, María Inés Barceló, Francisco Gilo, Stoyan Popkirov, Pavel Stourac, Josep Dalmau
OBJECTIVE: To report the clinical characteristics of 12 patients with limbic encephalitis (LE) who were antibody-negative after a comprehensive immunological study. METHODS: Review of clinical records of 163 patients with LE. Immunohistochemistry on rat brain, cultured neurons, and cell-based assays were used to identify neuronal autoantibodies. Patients were included if 1) there was adequate clinical, CSF, and MRI information to classify the syndrome as LE, 2) MRI images were accesible for central review, and 3) serum and CSF were available and confirmed negative for neuronal antibodies...
April 18, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29664808/trends-in-pharmacological-emergency-treatment-of-patients-suffering-from-schizophrenia-over-a-16-year-observation-period
#3
Monika Edlinger, Anna-Sophia Welte, Nursen Yalcin-Siedentopf, Georg Kemmler, Felix Neymeyer, W Wolfgang Fleischhacker, Alex Hofer
Patients suffering from schizophrenia are often treated in locked psychiatric units because of psychomotor agitation, hostility and aggressive behavior, or suicidality. Because of legal conditions, investigations on these acutely ill patients are difficult, and many studies do not represent 'real-life psychiatry'. This retrospective survey was conducted at the Department of Psychiatry, Psychotherapy and Psychosomatics of the Medical University, Innsbruck, Austria. Data were collected from the records of all adult inpatients suffering from a schizophrenia spectrum disorder according to the International Classification of Diseases, 10th ed...
April 16, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29664448/a-review-of-the-bidirectional-relationship-between-psychiatric-disorders-and-diabetes-mellitus
#4
Abdulrahman A Al-Atram
The prevalence of type 2 diabetes is rising worldwide, including Saudi Arabia. Among patients with diabetes, 30% suffer from mental disorders, such as depression, schizophrenia, delirium, and substance misuse (for example, tobacco smoking). Moreover, these disorders appear to share a bidirectional relationship with diabetes. For example, the incidence of diabetes has been shown to be 2-4 times greater in patients with schizophrenia than in normal individuals; also, there is a known association between depression and diabetes...
April 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/29663191/older-adults-with-autism-spectrum-disorders-in-sweden-a-register-study-of-diagnoses-psychiatric-care-utilization-and-psychotropic-medication-of-601-individuals
#5
Lena Nylander, Anna Axmon, Petra Björne, Gerd Ahlström, Christopher Gillberg
In a Swedish sample of persons eligible for disability services and aged 55 years or older in 2012, persons (n = 601) with autism spectrum disorder diagnoses registered in specialist care were identified. Register data concerning diagnoses of other psychiatric disorders, psychiatric care, and psychiatric medication were reviewed. More than 60% had been in contact with psychiatric care. The majority had no intellectual disability (ID) diagnosis recorded during the study period. Apart from ID, affective disorders, anxiety and psychotic disorders were most commonly registered; alcohol/substance abuse disorders were uncommon...
April 16, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29661694/descriptive-epidemiology-of-parkinsonism-in-the-canton-of-geneva-switzerland
#6
Vanessa Fleury, Pauline Brindel, Nicolas Nicastro, Pierre R Burkhard
OBJECTIVES: A large descriptive cross-sectional population-based prevalence study as well as a retrospective incidence study were undertaken to ascertain the frequency of Parkinson's Disease (PD) and other types of degenerative and non-degenerative parkinsonism in the Canton of Geneva, Switzerland. METHODS: An extensive case-finding approach including records from public hospitals, private neurologists and nursing homes was utilized. All patients with a diagnosis of parkinsonism established between 2003 and 2012 were included...
April 9, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29659374/intravenous-immunoglobulin-and-methylprednisolone-for-clozapine-associated-perimyocarditis
#7
Albert Cheng, Mohanned Ahmed, Waqas Shuaib
CLINICAL FEATURES: Cardiotoxicity is a rare but serious side effect of clozapine. We present a case of a psychiatric patient on chronic clozapine 75 mg daily, who presented with congestive heart failure secondary to the cardiotoxic effects of the psychiatric medication. THERAPEUTIC CHALLENGE: Conventional heart failure treatment failed to improve symptoms. SOLUTION: A course of 40 mg of intravenous immunoglobulin and 125 mg of steroids was implemented, after which the patient made a full recovery...
March 28, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29659348/evaluation-of-estrogen-and-g-protein-coupled-estrogen-receptor-1-gper-levels-in-drug-na%C3%A3-ve-patients-with-attention-deficit-hyperactivity-disorder-adhd
#8
Nilfer Sahin, Hatice Altun, Ergül Belge Kurutaş, Ebru Fındıklı
Estrogen has a crucial role in the regulation of reproductive and neuroendocrine function and exerts its effects through two classes of receptors, nuclear and membrane estrogen receptors (mERs). G protein-coupled estrogen receptor 1 (GPER) is a member of mERs, and despite limited research on the levels of GPER in patients with psychiatric diseases, a role of GPER in such conditions has been suggested. Here we evaluated serum estrogen and GPER levels in children with attention deficit hyperactivity disorder (ADHD) in relation to their age- and gender-matched healthy controls...
April 16, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29658982/behavioural-changes-in-patients-with-intellectual-disability-treated-with-brivaracetam
#9
E Andres, F Kerling, H Hamer, M Winterholler
OBJECTIVE: The purpose of this study was to evaluate the tolerability and efficacy of brivaracetam (BRV) in residential patients at our epilepsy centre. PATIENTS AND METHODS: We assessed retrospectively 33 patients (14 females; mean age 38.2 years, with range 17-63 years) with intellectual disability (ID) and drug-resistant epilepsy using an industry-independent, non-interventional study design based on standardized daily seizure records. Mean seizure frequency was compared between the 3-month baseline period and subsequent 3-month treatment period...
April 16, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29657697/characterizing-mortality-from-substance-abuse-in-iran-an-epidemiological-study-during-march-2014-to-february-2015
#10
Fatemeh Shahbazi, Seyed Davood Mirtorabi, Mohammad Reza Ghadirzadeh, Seyed Saeed Hashemi-Nazari, Abdolrazagh Barzegar
Background: Drug abuse is a severe and chronic disorder that leaves morbidity, disability and premature mortality in the society. The study of death due to substance abuse provides useful information for local, national and international administrators. Thus, by identifying the factors that have an impact on overdose-related mortality we can provide suitable intervention for vulnerable groups. The aim of this study was an investigation of mortality rate caused by consumption of narcotic and psychoactive substances in Iran...
July 2017: Addiction & Health
https://www.readbyqxmd.com/read/29657695/effectiveness-of-transactional-analysis-group-therapy-on-addiction-intensity-of-woman-patients-treated-with-methadone
#11
Niloofar Etemadi-Chardah, Bahman Matinpour, Rasoul Heshmati
Background: Addiction brings about severe and profound physical, psychological and social damages such as divorce, crime, and unemployment. The present study was to investigate the effectiveness of transactional analysis (TA) therapy on addiction intensity of woman patients treated with methadone. Methods: The research design was quasi-experimental with a pretest-posttest and a control group. The statistical population consisted of all the addicted women who referred to any drug rehabilitation center of Tehran, Iran, in 2016...
July 2017: Addiction & Health
https://www.readbyqxmd.com/read/29656188/inhibition-of-the-dopamine-transporter-as-an-animal-model-of-bipolar-disorder-mania-locomotor-response-neuroimmunological-profile-and-pharmacological-modulation
#12
Juliana R Bastos, Katherinne M Perico, Érica L Marciano Vieira, Antônio L Teixeira, Fabiana S Machado, Aline S de Miranda, Fabrício A Moreira
Inhibition of dopamine transporter (DAT) by GBR12909 has been proposed as a pharmacological model of mania related to bipolar disorder (BD). Here we tested the hypothesis that GBR12909 injection impairs habituation and induces hyperlocomotion in mice, along with changes in cytokines and neurotrophic factors levels, as observed in BD patients. We also tested if lithium carbonate, sodium valproate and aripiprazole prevent GBR12909-induced locomotion. Male Swiss mice received GBR12909 (15 mg/kg) injections and locomotor responses were quantified in an open field...
April 6, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29653321/neurodevelopmental-comorbidities-and-seizure-control-24-months-after-a-first-unprovoked-seizure-in-children
#13
Eva Åndell, Torbjörn Tomson, Sofia Carlsson, Kristina Tedroff, Per Åmark
PURPOSE: To follow children with newly diagnosed unprovoked seizures to determine (1) whether the prevalence of neurodevelopmental comorbidities and cerebral palsy (CP) changed after the initial seizure, and (2) the association between studied comorbidities and seizures 13-24 months after seizure onset or initiation of treatment. METHODS: Analyses were based on 750 children (28 days-18 years) with a first unprovoked seizure (index) included in a population-based Incidence Registry in Stockholm between 2001 and 2006...
March 20, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29652821/who-are-the-subjects-with-gambling-related-problems-requiring-treatment-a-study-in-northern-italy
#14
Raimondo Maria Pavarin, Angelo Fioritti, Silvia Marani, Daniele Gambini, Elsa Turino, Antonella Piazza
BACKGROUND: This study analyzes data related to Hospital (HOS), Public Treatment Service Dedicated to Drug Addicts (SERD), or Community Mental Health Center (CMHC) clients with a first diagnosis of Pathological Gambling (PG) in the period 2000/2016 in Northern Italy. The aims were to describe trends and characteristics of pathological gamblers (PGs) and to estimate the prevalence of other diagnoses before or after the diagnosis of PG. METHODS: Participants aged over 17 years with an ICD-9 or ICD-10 PG diagnosis were selected...
April 13, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29651743/polypharmacy-in-palliative-care-copd-and-multimorbidity-a-case-report
#15
Marcel Rowhani, Bernhard Iglseder
This is the case report of an 80-year-old woman with advanced chronic obstructive pulmonary disease (COPD), multimorbidity and frailty. Despite regular critical re-evaluation of on-going medication, a significant reduction of prescribed medication was not achieved up until the patient's terminal phase, and this may have contributed to several episodes of delirium. It was particularly difficult to reduce the number of prescribed drugs due to cardiovascular, endocrinologic, orthopaedic, neurologic, psychiatric and pulmonary comorbidities...
April 12, 2018: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29651622/utilization-of-psychiatric-care-and-antidepressants-among-people-with-different-severity-of-depression-a-population-based-cohort-study-in-stockholm-sweden
#16
Yuying Sun, Jette Möller, Andreas Lundin, Samuel Y S Wong, Benjamin H K Yip, Yvonne Forsell
PURPOSE: To identify how severity of depression predicts future utilization of psychiatric care and antidepressants. METHODS: Data derived from a longitudinal population-based study in Stockholm, Sweden, include 10443 participants aged 20-64 years. Depression was assessed by Major Depression Inventory and divided into subsyndromal, mild, moderate and severe depression. Outcomes were the first time of hospitalization, specialized outpatient care and prescribed drugs obtained from national register records...
April 12, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29644946/the-incidence-risk-factors-and-chronobiology-of-acute-myocardial-infarction-ten-years-after-hurricane-katrina
#17
John C Moscona, Matthew N Peters, Rohit Maini, Paul Katigbak, Bradley Deere, Holly Gonzales, Christopher Westley, Hassan Baydoun, Kapil Yadav, Patrick Ters, Ahmad Jabbar, Alaa Boulad, Indrajeet Mahata, Taraka V Gadiraju, Ryan Nelson, Sudesh Srivastav, Anand Irimpen
OBJECTIVE: The purpose of this study was to investigate the 10-year impact of Hurricane Katrina on the incidence of acute myocardial infarction (AMI) along with contributing risk factors and any alteration in chronobiology of AMI. METHODS: A single-center, retrospective, comparison study of AMI incidence was performed at Tulane University Health Sciences Center from 2 years before Hurricane Katrina to 10 years after Hurricane Katrina. A 6-year, pre-Katrina and 10-year, post-Katrina cohort were also compared according to pre-specified demographic, clinical, and chronobiological data...
April 12, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29644197/clinical-spectrum-of-autoerythrocyte-sensitization-syndrome-a-series-of-five-cases
#18
Nandakishore Singh Thokchom, D Pradeepa, N A Bishurul Hafi, Kapila Verma
Autoerythrocyte sensitization syndrome (Gardner Diamond syndrome or GDS) is a rare syndrome characterized by painful and spontaneous purpura commonly affecting adult women, and is mostly associated with psychiatric illness. Diagnosis is mainly based on clinical presentation, exclusion of other simulating diseases, and psychiatric evaluation. Only few cases have been reported till date. We report five cases of spontaneous purpura with a normal investigation profile, except for iron deficiency anemia in 1 patient, of which three had associated underlying psychiatric illness...
March 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29628879/dopamine-effort-based-choice-and-behavioral-economics-basic-and-translational-research
#19
REVIEW
John D Salamone, Merce Correa, Jen-Hau Yang, Renee Rotolo, Rose Presby
Operant behavior is not only regulated by factors related to the quality or quantity of reinforcement, but also by the work requirements inherent in performing instrumental actions. Moreover, organisms often make effort-related decisions involving economic choices such as cost/benefit analyses. Effort-based decision making is studied using behavioral procedures that offer choices between high-effort options leading to relatively preferred reinforcers vs. low effort/low reward choices. Several neural systems, including the mesolimbic dopamine (DA) system and other brain circuits, are involved in regulating effort-related aspects of motivation...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29628501/excitatory-and-inhibitory-synaptic-dysfunction-in-mania-an-emerging-hypothesis-from-animal-model-studies
#20
REVIEW
Yeunkum Lee, Yinhua Zhang, Shinhyun Kim, Kihoon Han
Bipolar disorder (BD) is a common psychiatric disorder characterized by recurrent mood swings between depression and mania, and is associated with high treatment costs. The existence of manic episodes is the defining feature of BD, during which period, patients experience extreme elevation in activity, energy, and mood, with changes in sleep patterns that together severely impair their ability to function in daily life. Despite some limitations in recapitulating the complex features of human disease, several rodent models of mania have been generated and characterized, which have provided important insights toward understanding its underlying pathogenic mechanisms...
April 9, 2018: Experimental & Molecular Medicine
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