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https://www.readbyqxmd.com/read/29934975/autism-throughout-genetics-perusal-of-the-implication-of-ion-channels
#1
REVIEW
Marwa Daghsni, Mohamad Rima, Ziad Fajloun, Michel Ronjat, Juan L Brusés, Ridha M'rad, Michel De Waard
BACKGROUND: Autism spectrum disorder (ASD) comprises a group of neurodevelopmental psychiatric disorders characterized by deficits in social interactions, interpersonal communication, repetitive and stereotyped behaviors and may be associated with intellectual disabilities. The description of ASD as a synaptopathology highlights the importance of the synapse and the implication of ion channels in the etiology of these disorders. METHODS: A narrative and critical review of the relevant papers from 1982 to 2017 known by the authors was conducted...
June 22, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29934097/test-characteristics-of-a-drug-cage-questionnaire-for-the-detection-of-non-alcohol-substance-use-disorders-in-trauma-inpatients
#2
Zachary D W Dezman, David A Gorelick, Carl A Soderstrom
BACKGROUND: Non-alcohol substance use disorders (drug use disorders [DUDs]) are common in trauma patients. OBJECTIVE: To determine the test characteristics of a 4-item drug CAGE questionnaire to detect DUDs in a cohort of adult trauma inpatients. METHODS: Observational cross-sectional cohort of 1,115 adult patients admitted directly to a level-one trauma center between September, 1994 and November, 1996. All participants underwent both a 4-item drug CAGE questionnaire and the substance use disorder section of a structured psychiatric diagnostic clinical interview (SCID) (DSM-IIIR criteria), administered by staff unaware of their clinical status...
June 13, 2018: Injury
https://www.readbyqxmd.com/read/29933206/the-pattern-of-pharmacological-treatment-of-bipolar-patients-discharged-from-psychiatric-units-in-poland
#3
Jan Jaracz, Edyta Tetera- Rudnicka, Magdalena Bierejszyk, Kaja Witczyk, Agnieszka Raczyńska, Wojciech Nowak, Anna Pisarczyk, Krzysztof Woźniak, Wojciech Czernaś, Adam Moniakowski, Krystyna Jaracz
BACKGROUND: The concomitant use of two or more mood stabilisers (MS), second-generation antipsychotics (SGA), lamotrigine as well as antidepressants, is frequently reported in the treatment of bipolar patients The aim of this study was to investigate the pattern of pharmacological treatment with special regard to polypharmacy defined as two or more psychiatric drugs taken at the same time in the same patients with bipolar disorder discharged from psychiatric units in Poland. METHOD: Pharmacotherapy of 127 consecutive patients (57 females and 70 males) with an ICD-10 diagnosis of bipolar disorder (BP) at the point of discharge from five psychiatric regional hospitals/units in Poland, was evaluated in 2015/2016 on the basis of medical files...
February 5, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29930934/synthetic-and-non-synthetic-cannabinoid-drugs-and-their-adverse-effects-a-review-from-public-health-prospective
#4
REVIEW
Koby Cohen, Aviv M Weinstein
There is a growing use of novel psychoactive substances containing synthetic cannabinoids. Synthetic cannabinoid products have effects similar to those of natural cannabis, yet, these drugs are more potent and dangerous, and have been associated with dangerous adverse effects. Here, we review current literature on the epidemiology, acute, and chronic effects of synthetic and natural cannabinoid-based drugs. Synthetic drugs contain a mixture of psychoactive compounds that mostly bind cannabinoid receptors with high potency...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29930388/the-risk-for-drug-abuse-alcohol-use-disorder-and-psychosocial-dysfunction-in-offspring-from-high-density-pedigrees-its-moderation-by-personal-family-and-community-factors
#5
Kenneth S Kendler, Henrik Ohlsson, Silviu Bacanu, Jan Sundquist, Kristina Sundquist
Previous high-risk family designs in psychiatry have focused largely on offspring of affected parents. We take a pedigree-based approach and examine the social, psychological, and psychiatric features of offspring from extended pedigrees selected for high-densities of alcohol use disorder (AUD) or drug abuse (DA). We identified, from the Swedish population, 665,715 pedigrees containing a mean of 17.9 parents, aunts/uncles, grandparents, and cousins of a core full-sibship we term the pedigree offspring. We then derived 13 empirical classes of these pedigrees based on the density of cases of AUD and DA...
June 21, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29929905/risk-factors-of-psychotropic-polypharmacy-in-the-treatment-of-children-and-adolescents-with-psychiatric-disorders
#6
Rohan Medhekar, Rajender Aparasu, Vinod Bhatara, Michael Johnson, Joy Alonzo, Heidi Schwarzwald, Hua Chen
OBJECTIVE: To examine patient and provider characteristics associated with the use of pediatric psychotropic polypharmacy. METHODS: A retrospective study was conducted on children with psychiatric disorder diagnosis and treatment using the 2013-2015 claims data from a Pediatric Medicaid Managed Care Plan. Psychotropic polypharmacy was defined as the receipt of ≥2 psychotropic medications from different drug classes concurrently for ≥60 days. Stratified logistic regression analyses based on the number of prescribers involved in the treatment, i...
June 13, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29928985/design-and-characterization-of-emulsified-spray-dried-alginate-microparticles-as-a-carrier-for-the-dually-acting-drug-roflumilast
#7
Azza A Mahmoud, Nermeen A Elkasabgy, Abdel Fatah A Abdelkhalek
Roflumilast is a selective inhibitor of phosphodiesterase-4 isoenzyme in lung cells. Having psychiatric adverse reactions when administered orally affects negatively the patients' adherence to the drug. This work aimed to prepare emulsified spray dried alginate microparticles for the pulmonary delivery of roflumilast. Sodium alginate was used as microparticle-forming material, isopropyl myristate as an oil, Tween®80 as surfactant and calcium beta-glycerophosphate as cross-linking agent to enhance the mechanical properties of the particles...
June 18, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29928290/psychotic-mania-as-the-solitary-manifestation-of-neurosyphilis
#8
Eun Hyun Seo, Hae Jung Yang, Sang Hoon Kim, Jung Hyun Park, Hyung-Jun Yoon
Background: Neurosyphilis remains a diagnostic challenge in current psychiatric practice because of its pleomorphic psychiatric manifestations. Although neurosyphilis can present with a wide range of psychiatric symptoms, psychotic mania as its solitary manifestation is an unusual phenomenon. Case presentation: A 46-year-old man, with no history of any psychiatric disorder, exhibited abruptly developed symptoms of psychotic mania. He was admitted to a psychiatric ward for further evaluation and treatment...
2018: Annals of General Psychiatry
https://www.readbyqxmd.com/read/29926268/investigation-into-the-plasma-concentration-of-%C3%AF-3-polyunsaturated-fatty-acids-in-japanese-attention-deficit-hyperactivity-disorder-patients
#9
Ken Yonezawa, Shunsuke Nonaka, Yuka Iwakura, Yuka Kusano, Yuko Funamoto, Nobukazu Kanchi, Naohiro Yamaguchi, Yuko Kusumoto, Akira Imamura, Hiroki Ozawa
Several studies report that patients with attention-deficit hyperactivity disorder (ADHD) have a low plasma concentration of polyunsaturated fatty acids (PUFAs). Since fish intake varies among countries and is high in Japan, those results may not apply to Japanese patients with ADHD. However, there is currently not enough evidence to support this. We compared the plasma PUFAs levels of patients with ADHD with the standard reference levels for healthy subjects, and examined the relationship between those PUFAs levels and the subject's psychological evaluation...
June 20, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29923970/vortioxetine-overdose-in-a-suicidal-attempt-a-case-report
#10
Mario Gennaro Mazza, Aurora Rossetti, Eugenia Rossana Botti, Massimo Clerici
RATIONALE: Vortioxetine is a new multimodal antidepressant approved by the Food and Drug Administration for the treatment of Major Depressive Disorder and recently introduced in Europe. While antidepressant properties of vortioxetine and its tolerability have been demonstrated by preclinical and clinical studies data on the safety of vortioxetine after overdose are still lacking. PATIENT CONCERNS: A 50-year-old Caucasian man presenting a severe depressive episode that in a suicide attempt he took vortioxetine at 250 mg...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923275/exploring-barriers-and-facilitators-in-the-implementation-and-use-of-guideline-recommendations-on-antipsychotic-drug-prescriptions-for-people-with-intellectual-disability
#11
Lotte Ramerman, Pieter J Hoekstra, Gerda de Kuijper
BACKGROUND: It is unknown why professionals' adherence to guideline recommendations on antipsychotic drug prescription in the intellectual disabilities care is insufficient. This study aimed to explore barriers and facilitators in the implementation and use of these recommendations. METHODS: In-depth interviews with four intellectual disability physicians, two psychiatrists and five behavioural scientists were used to explore the implementation and use of guideline recommendations...
June 20, 2018: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/29922129/sex-differences-in-psychiatric-disease-a-focus-on-the-glutamate-system
#12
REVIEW
Megan M Wickens, Debra A Bangasser, Lisa A Briand
Alterations in glutamate, the primary excitatory neurotransmitter in the brain, are implicated in several psychiatric diseases. Many of these psychiatric diseases display epidemiological sex differences, with either males or females exhibiting different symptoms or disease prevalence. However, little work has considered the interaction of disrupted glutamatergic transmission and sex on disease states. This review describes the clinical and preclinical evidence for these sex differences with a focus on two conditions that are more prevalent in women: Alzheimer's disease and major depressive disorder, and three conditions that are more prevalent in men: schizophrenia, autism spectrum disorder, and attention deficit hyperactivity disorder...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29920885/comprehensive-comparison-of-monotherapies-for-psychiatric-hospitalization-risk-in-bipolar-disorders
#13
Anastasiya Nestsiarovich, Aurélien J Mazurie, Nathaniel G Hurwitz, Berit Kerner, Stuart J Nelson, Annette S Crisanti, Mauricio Tohen, Ronald L Krall, Douglas J Perkins, Christophe G Lambert
OBJECTIVES: This study compared 29 drugs for risk of psychiatric hospitalization in bipolar disorders, addressing the evidence gap on the >50 drugs used by US patients for treatment. METHODS: The Truven Health Analytics MarketScan® database was used to identify 190 894 individuals with bipolar or schizoaffective disorder who filled a prescription for one of 29 drugs of interest: lithium, first- or second-generation antipsychotics, mood-stabilizing anticonvulsants, and antidepressants...
June 19, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29916839/aripiprazole-in-a-patient-of-pla2g6-associated-neurodegeneration-with-psychosis
#14
Mao-Hsuan Huang, Yu-Chuan Chiu, Chia-Fen Tsai
PLA2G6-associated neurodegeneration is a major subtype of neurodegeneration with brain iron accumulation. Patients with PLA2G6-associated neurodegeneration usually present degenerative motor symptoms with neuropsychiatric disturbance. This report presents a patient with PLA2G6-related dystonia-parkinsonism, who had neuropsychiatric symptoms preceding movement symptoms. Antipsychotic drug was prescribed, and he developed parkinsonism years later. Differential diagnosis between drug-induced parkinsonism and PLA2G6-related dystonia-parkinsonism could be challenging...
June 18, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29915963/a-translational-perspective-on-histone-acetylation-modulators-in-psychiatric-disorders
#15
REVIEW
Surajit Ganguly, Subhendu Seth
A large volume of research now provides evidence correlating aberrant histone deacetylase (HDAC) activities and hypoacetylation of histones to disruptions in synaptic plasticity, neuronal survival/regeneration, memory formation and consolidation. Hence, maintaining the acetyl-histone homeostasis as a component of neuronal mechanisms by targeting HDACs has emerged as an exciting intervention strategy for several neuropsychiatric disorders. Though extensive preclinical animal studies have elevated the translational potential of HDAC inhibitors (HDACis) in psychiatric disorders, so far, the translational gain remains low...
June 19, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29913994/patients-referred-from-a-multidisciplinary-pain-clinic-to-the-social-worker-their-general-health-pain-condition-treatment-and-outcome
#16
Heli Aho, Timo Kauppila, Maija Haanpää
Background and aims As far as we know, the range of issues particular to social work, when working with clients at a pain clinic has not been previously researched. Methods A retrospective study of referrals at the multidisciplinary Pain Clinic of Helsinki University Central Hospital was conducted based on medical records, focusing on pain conditions, treatments and patient flow. Variables used were age, gender, pain conditions, treatment interventions, pain duration and intensity, disruption in everyday life due to pain, psychiatric co-morbidities, referrals, outside care providers, post-treatment care and health habits...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913083/risk-factors-for-recurrent-neurotrauma-a-population-based-study-in-southeastern-michigan
#17
R David Hayward, Mary M Fessler, Joseph Buck, Richard D Fessler
INTRODUCTION: Studies have shown an increased risk of traumatic brain injury (TBI) for individuals who suffer an initial TBI. The current study hypothesized that individuals with recurrent neurotrauma would originate from populations considered 'vulnerable', i.e. low income and/or with psychiatric comorbidities. METHODS: Data from the Michigan State Inpatient Database from 2006 to 2014 for the Detroit metropolitan area enlisted a study population of 50 744 patients with neurotrauma...
June 18, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29907742/nmda-antagonists-for-treating-the-non-motor-symptoms-in-parkinson-s-disease
#18
REVIEW
Brigitte Vanle, William Olcott, Jaime Jimenez, Luma Bashmi, Itai Danovitch, Waguih William IsHak
Among patients with Parkinson's disease (PD), depression is prevalent and disabling, impacting both health outcomes and quality of life. There is a critical need for alternative pharmacological methods to treat PD depression, as mainstream antidepressant drugs are largely ineffective in this population. Currently, there are no recommendations for the optimal treatment of PD neuropsychiatric symptoms. Given the dual antidepressant and anti-dyskinetic effects of ketamine and other N-methyl-D-aspartate (NMDA) antagonists for PD, this review aims to examine the current evidence of NMDA antagonists for treating neuropsychiatric symptoms, including memantine, amantadine, ketamine, dizoclopine, and d-cycloserine...
June 15, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29907425/repurposing-steroidogenesis-inhibitors-for-the-therapy-of-neuropsychiatric-disorders-promises-and-caveats
#19
REVIEW
Roberto Frau, Marco Bortolato
Steroids exert a profound influence on behavioral reactivity, by modulating the functions of most neurotransmitters and shaping the impact of stress and sex-related variables on neural processes. This background - as well as the observation that most neuroactive steroids (including sex hormones, glucocorticoids and neurosteroids) are synthetized and metabolized by overlapping enzymatic machineries - points to steroidogenic pathways as a powerful source of targets for neuropsychiatric disorders. Inhibitors of steroidogenic enzymes have been developed and approved for a broad range of genitourinary and endocrine dysfunctions, opening to new opportunities to repurpose these drugs for the treatment of mental problems...
May 11, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29906718/review-adjunctive-pharmacologic-approaches-for-benzodiazepine-tapers
#20
REVIEW
Justine W Welsh, Valeria Tretyak, R Kathryn McHugh, Roger D Weiss, Olivera Bogunovic
BACKGROUND: Many patients require discontinuation of benzodiazepines due to a reduction in drug efficacy over time, the development of a sedative use disorder, or unwanted side effects. Benzodiazepine discontinuation can pose a significant challenge for prescribing clinicians due to potential withdrawal symptoms and a recurrence of psychiatric complaints. METHODS: A PubMed literature search was conducted using the medical subject heading of benzodiazepines in combination with the following key words: discontinuation, withdrawal, detoxification, cessation, dependence, addiction, substance use disorders, or long term...
May 31, 2018: Drug and Alcohol Dependence
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