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https://www.readbyqxmd.com/read/28737765/adrenocorticotropic-hormone-and-1-25-dihydroxyvitamin-d3-enhance-human-osteogenesis-in-vitro-by-synergistically-accelerating-the-expression-of-bone-specific-genes
#1
Irina L Tourkova, Li Liu, Nareerat Sutjarit, Quitterie C Larrouture, Jianhua Luo, Lisa J Robinson, Harry C Blair
To improve definition of the physical and hormonal support of bone formation, we studied differentiation of human osteoblasts in vitro at varying combinations of ACTH, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D), and extracellular calcium, with and without added cortisol. Bone mineralization, alkaline phosphatase activity, and osteoblast-specific markers RunX2, osterix, and collagen I increased with 10 pM ACTH, 10 nM 1,25(OH)2D, or at 2 mM calcium with important synergistic activity of combinations of any of these stimuli...
July 24, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28736298/calcitriol-mediated-reduction-in-ifn-%C3%AE-output-in-t-cell-large-granular-lymphocytic-leukemia-requires-vitamin-d-receptor-upregulation
#2
M Paige Kulling, C Kristine Olson, L Thomas Olson, E Cait Hamele, N Kathryn Carter, J David Feith, P Thomas Loughran
Constitutively activated STAT1 and elevated IFN-γ are both characteristic of T cell large granular lymphocytic leukemia (T-LGLL), a rare incurable leukemia with clonal expansion of cytotoxic T cells due to defective apoptosis. Interferon gamma (IFN-γ) is an inflammatory cytokine that correlates with worse progression and symptomology in multiple autoimmune diseases and cancers. In canonical IFN-γ-STAT1 signaling, IFN-γ activates STAT1, a transcription factor, via phosphorylation of tyrosine residue 701 (p-STAT1)...
July 20, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28727644/cariprazine-specificity-profile-in-the-treatment-of-acute-schizophrenia-a-meta-analysis-and-meta-regression-of-randomized-controlled-trials
#3
Filippo Corponi, Alessandro Serretti, Stuart Montgomery, Chiara Fabbri
Cariprazine is a new dopamine D2 and D3 receptor partial agonist antipsychotic. Meta-analytic evidence of efficacy in acute schizophrenia and specific groups of patients is lacking. We carried out a meta-analysis in patients with acute schizophrenia to evaluate the efficacy of cariprazine over placebo and active comparators in overall symptoms, positive and negative symptoms and quality of life. Low and high (≥6 mg/day) doses were tested separately. The possible effect of clinical-demographic modulators was also tested...
July 19, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28720548/pxapn5-serves-as-a-functional-receptor-of-cry2ab-in-plutella-xylostella-l-and-its-binding-domain-analysis
#4
Zhi-Zhen Pan, Lian Xu, Bo Liu, Jing Zhang, Zheng Chen, Qing-Xi Chen, Yu-Jing Zhu
Lepidopteran midgut aminopeptidases N (APNs) are widely studied for their potential roles as one of the receptors for the Bacillus thuringiensis (Bt) crystal insecticidal toxins. In the present study, a loss of function analyses by RNAi (RNA interference) silencing of the Plutella xylostella APN5 (PxAPN5), a binding protein of Cry2Ab, were performed. The knocking down of PxAPN5 in P. xylostella larvae greatly reduced their susceptibility to Cry2Ab and led to a decrease of Cry2Ab binding to P. xylostella midgut...
July 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28719834/the-exon3-deleted-growth-hormone-receptor-gene-polymorphism-d3-ghr-is-associated-with-insulin-and-spontaneous-growth-in-short-sga-children-nesgas
#5
Mathilde Gersel Wegmann, Ajay Thankamony, Edna Roche, Hilary Hoey, Jeremy Kirk, Guftar Shaikh, Sten-A Ivarsson, Olle Söder, David B Dunger, Anders Juul, Rikke Beck Jensen
OBJECTIVE: The effect of a common polymorphism in the Growth Hormone (GH) receptor (d3-GHR) gene on growth, metabolism and body composition was examined in short children born small for gestational age (SGA) on GH treatment. DESIGN: In 96 prepubertal, short SGA children treated with high-dose GH (67μg/kg/day) in the NESGAS study, insulin sensitivity (IS), insulin secretion and disposition index (DI) were determined during the first year of treatment. Body composition was analysed by DXA...
July 12, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28716760/properties-of-purified-cyp2r1-in-a-reconstituted-membrane-environment-and-its-25-hydroxylation-of-20-hydroxyvitamin-d3
#6
Chloe Y S Cheng, Tae-Kang Kim, Saowanee Jeayeng, Andrzej T Slominski, Robert C Tuckey
Recent studies indicate that CYP2R1 is the major 25-hydroxylase catalyzing the first step in vitamin D activation. Since the catalytic properties of CYP2R1 have been poorly studied to date and it is a membrane protein, we examined the purified enzyme in a membrane environment. CYP2R1 was expressed in E. coli and purified by nickel affinity- and hydrophobic interaction-chromatography and assayed in a reconstituted membrane system comprising phospholipid vesicles plus purified human NADPH-P450 oxidoreductase...
July 14, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28716664/advances-and-challenges-in-the-search-for-d2-and-d3-dopamine-receptor-selective-compounds
#7
REVIEW
Amy E Moritz, R Benjamin Free, David R Sibley
Compounds that target D2-like dopamine receptors (DRs) are currently used as therapeutics for several neuropsychiatric disorders including schizophrenia (antagonists) and Parkinson's disease (agonists). However, as the D2R and D3R subtypes are highly homologous, creating compounds with sufficient subtype-selectivity as well as drug-like properties for therapeutic use has proved challenging. This review summarizes the progress that has been made in developing D2R- or D3R-selective antagonists and agonists, and also describes the experimental conditions that need to be considered when determining the selectivity of a given compound, as apparent selectivity can vary widely depending on assay conditions...
July 14, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28708884/a-jak1-2-inhibitor-baricitinib-inhibits-osteoclastogenesis-by-suppressing-rankl-expression-in-osteoblasts-in-vitro
#8
Kohei Murakami, Yasuhiro Kobayashi, Shunsuke Uehara, Takako Suzuki, Masanori Koide, Teruhito Yamashita, Midori Nakamura, Naoyuki Takahashi, Hiroyuki Kato, Nobuyuki Udagawa, Yukio Nakamura
The Janus kinases (Jaks) are hubs in the signaling process of more than 50 cytokine or hormone receptors. However, the function of Jak in bone metabolism remains to be elucidated. Here, we showed that the inhibition of Jak1 and/or Jak2 in osteoblast-lineage cells led to impaired osteoclastogenesis due to the reduced expression of receptor activator of nuclear factor-κB ligand (RANKL). Murine calvaria-derived osteoblasts induced differentiation of bone marrow cells into osteoclasts in the presence of 1,25-dihydroxyvitamin D3 (1,25D3) and prostaglandin E2 (PGE2) in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28707894/vitamin-d-receptor-regulates-amyloid-beta-1-42-production-with-protein-disulfide-isomerase-a3
#9
Duygu Gezen-Ak, Irem L Atasoy, Esin Candas, Merve Alaylioglu, Selma Yilmazer, Erdinc Dursun
The challenge of understanding the biology of neuronal amyloid processing could provide a basis for understanding the amyloid pathology in Alzheimer's disease (AD). Based on our previous studies we have suggested that AD might be the consequence of a hormonal imbalance in which the critical hormone is vitamin D. The present study primarily focused on the creation of a condition that prevents the genomic or non-genomic action of vitamin D by disrupting vitamin D receptors (VDR or PDIA3/1,25MARRS); the effects of these disruptions on the series of proteins involved in secretases that play a crucial role in amyloid pathology and on amyloid beta (Aβ) production in primary cortical neurons were observed...
July 14, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28705801/the-mir-15-family-reinforces-the-transition-from-proliferation-to-differentiation-in-pre-b-cells
#10
Silke E Lindner, Michael Lohmüller, Bianka Kotkamp, Fabian Schuler, Zeynep Knust, Andreas Villunger, Sebastian Herzog
Precursor B lymphocytes expand upon expression of a pre-B cell receptor (pre-BCR), but then transit into a resting state in which immunoglobulin light chain gene recombination is initiated. This bi-phasic sequence is orchestrated by the IL-7 receptor (IL-7R) and pre-BCR signaling, respectively, but little is known about microRNAs fine-tuning these events. Here, we show that pre-B cells lacking miR-15 family functions exhibit prolonged proliferation due to aberrant expression of the target genes cyclin E1 and D3...
July 13, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28704278/trace-amine-associated-receptor-1-agonists-ro5263397-and-ro5166017-attenuate-quinpirole-induced-yawning-but-not-hypothermia-in-rats
#11
Justin N Siemian, Yanan Zhang, Jun-Xu Li
Increasing evidence suggests that trace amine-associated receptor 1 (TAAR1) is an important modulator of the dopaminergic system. Existing molecular evidence indicates that TAAR1 regulates dopamine levels through interactions with dopamine transporters and D2 receptors. However, investigations to date have not been exhaustive and other pathways may be involved. In this study, we used a well-described set of behaviors, quinpirole-induced yawning and hypothermia, to explore the potential interaction of TAAR1 and D3 receptors, which are members of the 'D2-like' dopamine receptor subfamily...
July 12, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28696084/can-vitamin-d-deficiency-influence-muscle-performance-in-post-menopausal-women-a-multicenter-retrospective-study
#12
Giovanni Iolascon, Giulia Letizia Mauro, Pietro Fiore, Carlo Cisari, Maria Grazia Benedetti, Lorenzo Panella, Alessandro DE Sire, Dario Calafiore, Antimo Moretti, Francesca Gimigliano
BACKGROUND: The presence of the vitamin D receptor (VDR) has been recently demonstrated in human muscle supporting the theory of a role of vitamin D in the proliferation and differentiation of muscle cells. So far only few studies investigated the association between vitamin D and muscle performance in post-menopausal women. AIM: To define the functional impact of vitamin D deficiency. DESIGN: Multicenter retrospective study. SETTING: Five Italian outpatient services of Physical and Rehabilitation Medicine (PRM)...
July 10, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28692485/safety-and-tolerability-of-cariprazine-in-patients-with-acute-exacerbation-of-schizophrenia-a-pooled-analysis-of-four-phase-ii-iii-randomized-double-blind-placebo-controlled-studies
#13
Willie Earley, Suresh Durgam, Kaifeng Lu, István Laszlovszky, Marc Debelle, John M Kane
Cariprazine, a potent dopamine D3 and D2 receptor partial agonist antipsychotic with preferential binding to D3 receptors, is Food and Drug Administration approved for treating schizophrenia and manic or mixed episodes of bipolar I disorder. A post-hoc safety/tolerability analysis of data from the four acute trials in the cariprazine schizophrenia clinical development program (NCT00404573; NCT00694707; NCT01104766; NCT01104779) was carried out using the overall safety population (all patients who received ≥1 dose of study drug) and modal daily dose subgroups (1...
July 7, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28692301/high-dose-vitamin-d3-during-tuberculosis-treatment-in-mongolia-a-randomised-controlled-trial
#14
Davaasambuu Ganmaa, Baatar Munkhzul, Wafaie Fawzi, Donna Spiegelman, Walter C Willett, Purev Bayasgalan, Erkhembayar Baasansuren, Burneebaatar Buyankhishig, Sereeter Oyun-Erdene, David A Jolliffe, Theodoros Xenakis, Sabri Bromage, Barry R Bloom, Adrian R Martineau
RATIONALE: Existing trials of adjunctive vitamin D in the treatment of pulmonary tuberculosis (PTB) are variously limited by small sample sizes, inadequate dosing regimens and high baseline vitamin D status among participants. Comprehensive analyses of the effects of genetic variation in the vitamin D pathway on response to vitamin D supplementation are lacking. OBJECTIVES: To determine the effect of high-dose vitamin D3 on response to antimicrobial therapy for PTB and to evaluate the influence of single nucleotide polymorphisms (SNPs) in vitamin D pathway genes on response to adjunctive vitamin D3...
July 10, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28689355/vitamin-d3-reverses-the-hippocampal-cytoskeleton-imbalance-but-not-memory-deficits-caused-by-ovariectomy-in-adult-wistar-rats
#15
Cassiana Siebert, Paula Pierozan, Janaina Kolling, Tiago Marcon Dos Santos, Matheus Coimbra Sebotaio, Eduardo Peil Marques, Helena Biasibetti, Aline Longoni, Fernanda Ferreira, Regina Pessoa-Pureur, Carlos Alexandre Netto, Angela T S Wyse
The objective of study was to investigate changes caused by ovariectomy (OVX) on aversive and non-aversive memories, as well as on cytoskeleton phosphorylating system and on vitamin D receptor (VDR) immunocontent in hippocampus. The neuroprotective role of vitamin D was also investigated. Ninety-day-old female Wistar rats were divided into four groups: SHAM, OVX, VITAMIN D and OVX + VITAMIN D; 30 days after the OVX, vitamin D supplementation (500 IU/kg), by gavage, for 30 days was started. Results showed that OVX impaired short-term and long-term recognition, and long-term aversive memories...
July 8, 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28686443/identification-of-peptidic-antagonists-of-vascular-endothelial-growth-factor-receptor-1-by-scanning-the-binding-epitopes-of-its-ligands
#16
Lei Wang, Lingyu Zhou, Marie Reille-Seroussi, Nathalie Gagey-Eilstein, Sylvain Broussy, Tianyu Zhang, Lili Ji, Michel Vidal, Wang-Qing Liu
Cancer angiogenesis is mainly initiated by the vascular endothelial growth factors (VEGFs). Based on the reported crystal structures of three natural ligands (VEGF-A, -B and PlGF) with the major receptors VEGFR-1 and VEGFR-2, we scanned receptor-binding epitopes of these ligands by designing linear and cyclic peptides in aim to disrupt the VEGF-A/VEGFR-1 interaction, which is implicated in cancer development. The ability of peptides to inhibit this interaction was evaluated by an ELISA-based assay. Several peptides, especially those mimicking loop one (L1) of these ligands that binds primarily to domain D3 of VEGFRs, have demonstrated higher inhibition for VEGF-A/VEGFR-1 binding...
July 7, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28684358/dopamine-d3-receptor-status-modulates-sexual-dimorphism-in-voluntary-wheel-running-behavior-in-mice
#17
Florian Klinker, Kathrin Ko Hnemann, Walter Paulus, David Liebetanz
Sexual dimorphism has been described in various aspects of physiological and pathophysiological processes involving dopaminergic signaling. This might account for the different disease characteristics in men and women in e.g. Parkinson's disease or ADHD. A better understanding might contribute to the future individualization of therapy. We examined spontaneous wheel running activity of male and female mice, homo- and heterozygote for dopamine D3 receptor deficiency (D3R -/- and D3R+/-), and compared them to wild type controls...
July 3, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28676457/on-the-role-of-classical-and-novel-forms-of-vitamin-d-in-melanoma-progression-and-management
#18
REVIEW
Andrzej T Slominski, Anna A Brozyna, Cezary Skobowiat, Michal A Zmijewski, Tae-Kang Kim, Zorica Janjetovic, Allen S Oak, Wojciech Jozwicki, Anton M Jetten, Rebecca S Mason, Craig Elmets, We Li, Robert M Hoffman, Robert C Tuckey
Melanoma represents a significant clinical problem affecting a large segment of the population with a relatively high incidence and mortality rate. Ultraviolet radiation (UVR) is an important etiological factor in malignant transformation of melanocytes and melanoma development. UVB, while being a full carcinogen in melanomagenesis, is also necessary for the cutaneous production of vitamin D3 (D3). Calcitriol (1,25(OH)2D3) and novel CYP11A1-derived hydroxyderivatives of D3 show anti-melanoma activities and protective properties against damage induced by UVB...
July 1, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28673024/ancestry-adjusted-vitamin-d-metabolite-concentrations-in-association-with-cytochrome-3a-cyp3a-polymorphisms
#19
Robin Taylor Wilson, Loren D Masters, Jill S Barnholtz-Sloan, Anna C Salzberg, Terryl J Hartman
This study investigates the association between genetic polymorphisms in CYP2R1, CYP24A1 and the CYP3A family with non-summer plasma concentrations of 25(OH)D3 and proportion 24,25(OH)2D3 among healthy individuals of Sub-Saharan African and European ancestry matched on age (±5 years; n = 188 in each ancestral group) in central suburban Pennsylvania (2006-09). Vitamin D metabolites were measured using high-performance liquid chromatography/tandem mass spectrometry. Paired multiple regression and adjusted least square means analyses were used to test for associations between genotype and log-transformed metabolite concentrations, adjusted for age, sex, West African genetic ancestry proportion, body mass index, oral contraceptive (OC) use, tanning bed use, vitamin D intake, days from summer solstice, time of day, and isoforms of the vitamin D receptor (VDR) and vitamin D binding protein...
June 30, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28672970/effect-of-vitamin-d-on-the-learning-and-memory-ability-of-fgr-rat-and-nmda-receptor-expression-in-hippocampus
#20
Lu Zong, Ping Chu, Pu Huang, Yulin Guo, Ye Lv
The aim of this study is to investigate the effect of vitamin D (VD) on the learning and memory ability of fetal growth restriction (FGR) rat and the expression of NMDA receptor in hippocampus. The FGR models of rat were established through passive smoking, and divided into two groups randomly, i.e. the control group and the observation group. Rats were fed regular diet with the addition of VD in the observation group. The serum level of 25(OH)-D3 was assayed in both groups of the rats at different time points using ELISA, and the learning and memory ability of rat aged 30 days were evaluated using Morris water maze and passive avoidance test...
July 2017: Experimental and Therapeutic Medicine
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