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https://www.readbyqxmd.com/read/29678723/modulatory-effect-of-dopamine-receptor-5-on-the-neurosecretory-dahlgren-cells-of-the-olive-flounder-paralichthys-olivaceus
#1
Zhaohui Lan, Wei Zhang, Jinling Xu, Mo Zhou, Yingxin Chen, Huafeng Zou, Weiqun Lu
A neuromodulatory role for dopamine has been reported for magnocellular neuroendocrine cells in the mammalian hypothalamus. We examined its potential role as a local intercellular messenger in the neuroendocrine Dahlgren cell population of the caudal neurosecretory system (CNSS) of the euryhaline flounder Paralichthys olivaceus. In vitro application of dopamine (DA) caused an increase in electrical activity (firing frequency, recorded extracellularly) of Dahlgren cells, recruitment of previously silent cells, together with a greater proportion of cells showing phasic (irregular) activity...
April 17, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29675928/differential-cardiac-sympatho-inhibitory-responses-produced-by-the-agonists-b-ht-933-quinpirole-and-immepip-in-normoglycemic-and-diabetic-pithed-rats
#2
Eduardo Rivera-Mancilla, Alain H Altamirano-Espinoza, Guadalupe Manrique-Maldonado, Belinda Villanueva-Castillo, Carlos M Villalón
This study compared the cardiac sympatho-inhibitory responses produced by agonists at α2 -adrenergic (B-HT 933), dopamine D2 -like (quinpirole) and histamine H3 /H4 (immepip) receptors between normoglycemic and streptozotocin-pretreated (diabetic) pithed rats. Intravenous (i.v.) continuous infusions of B-HT 933, quinpirole or immepip were used in normoglycemic and diabetic pithed rats to analyse their sympatho-inhibitory effects on the electrically-stimulated cardioaccelerator sympathetic outflow. Both in normoglycemic and diabetic animals, B-HT 933 (until 100 μg/kg...
April 19, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29671049/parent-offspring-cohabitation-after-weaning-inhibits-partner-preference-and-alters-central-oxytocin-and-dopamine-systems-in-adult-mandarin-vole
#3
Ruiyong Wu, Zhenzhen Song, Fadao Tai
In some mammals, offspring may live with their parents for a very long time after weaning, but little is known about the effect of post-weaning parent-offspring cohabitation on the behavioral and neurobiological development of offspring. Here, we explored the effect of this experience on partner preference in adult mandarin vole (Microtus mandarinus). Levels of central oxytocin (OT), tyrosine hydroxylase (TH), as well as OT receptor (OTR), dopamine D1-type and D2-type receptors (D1R and D2R) mRNA expression in the nucleus accumbens (NAcc) and medial amygdala (MeA) were also measured...
April 18, 2018: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/29669297/effects-of-apomorphine-a-dopamine-agonist-on-daphnia-magna-imaging-of-swimming-track-density-as-a-novel-tool-in-the-assessment-of-swimming-activity
#4
Adam Bownik, Natalia Sokołowska, Brygida Ślaska
Apomorphine (APO) is a non-selective agonist of dopamine receptor activating D2-like receptors. Although Daphnia has been used in neurotoxicology in toxicity testing, little is known on its behavioural and physiological responses to dopamine receptors ligands. Therefore, the aim of our study was to determine swimming behaviour (swimming track density, speed, turning activity) and physiological parameters such as heart rate, thoracic limb activity and post-abdominal claw movement frequency in daphnids exposed for 1, 2 and 4h to concentrations of 0...
April 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29664745/cross-tolerance-between-nitric-oxide-synthase-inhibition-and-atypical-antipsychotics-modify-nicotinamide-adenine-dinucleotide-phosphate-diaphorase-activity-in-mouse-lateral-striatum
#5
Sonia G Prieto, João C S Silva, Mairon O de Lima, Maria C Almeida, Marcela B Echeverry
Previous research indicates that the subchronic administration of NG-nitro-L-arginine (L-NOARG) produces tolerance to haloperidol-induced catalepsy in Swiss mice. The present study aimed to further investigate whether intermittent subchronic systemic administration of L-NOARG induces tolerance to the cataleptic effects of haloperidol as well as olanzapine or clozapine (Clz) in C57Bl mice after subchronic administration for 5 consecutive days. Striatal FosB protein expression was measured in an attempt to gain further insights into striatal mechanisms in antipsychotic-induced extrapyramidal symptoms side effects...
April 16, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29661100/progesterone-induced-mir-145-mir-143-inhibits-the-proliferation-of-endometrial-epithelial-cells
#6
Dong-Zhi Yuan, Yi Lei, Dan Zhao, Jun-Li Pan, You-Bo Zhao, Li Nie, Min Liu, Yun Long, Jin-Hu Zhang, Li-Min Yue
Our previous study showed that progesterone (P4) can specifically regulate the expression of some microRNAs (miRNAs) in endometrial epithelium. In the present study, we verified the P4-dependent expression of miR-145/miR-143 in endometrial epithelial cells, explored the regulative mechanism of the P4 receptor (PR), and investigated their effects on the proliferation of endometrial epithelial cells. Our results showed that P4 can induce the expression of miR-145/143 in endometrial epithelial cells by acting on the PR A subtype...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29660611/effect-of-in-vivo-exposure-to-ambient-fine-particles-pm-2-5-on-the-density-of-dopamine-d-2-like-receptors-and-dopamine-induced-35-s-gtp%C3%AE-s-binding-in-rat-prefrontal-cortex-and-striatum-membranes
#7
María-de-Los-Angeles Andrade-Oliva, Octavio-Gamaliel Aztatzi-Aguilar, Francisco García-Sierra, Andrea De Vizcaya-Ruiz, José-Antonio Arias-Montaño
Male Sprague-Dawley rats (8-9 weeks-old) were exposed for three days (acute exposure) or eight weeks (subchronic exposure) to purified air or concentrated ambient fine particles, PM2.5 (≤2.5 μm; 15 to 18-fold of ambient air; 370-445 μg/m3 ). In membranes from rat prefrontal cortex (PFC) or striatum, the density and function of dopamine D2 -like receptors (D2 Rs) were assessed by [3 H]-spiperone binding and dopamine-stimulated [35 S]-GTPγS binding, respectively. Glial activation was evaluated by immunoperoxidase labeling of the glial fibrillary acidic protein (GFAP)...
April 10, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29658442/evaluation-of-in-silico-anti-parkinson-potential-of-%C3%AE-asarone
#8
Meenakshi Gupta, Kamal Kant, Ruchika Sharma, Anoop Kumar
INTRODUCTION: Parkinson's disease is affecting millions of people worldwide. The prevalence of Parkinson's disease is 0.3% globally, rising to 1% in more than 60 years of age and 4% in more than 80 years of age and the figures are thought to be doubled by 2030. Thus, there is a great need to identify novel therapeutic strategies or candidate drug molecule which can rescue neuronal degeneration. β-asarone has potential to act as a neuroprotective agent but regarding its role in Parkinson disease, very few reports are available...
April 16, 2018: Central Nervous System Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29656874/regional-heterogeneity-of-d2-receptor-signaling-in-the-dorsal-striatum-and-nucleus-accumbens
#9
Pamela F Marcott, Sheng Gong, Prashant Donthamsetti, Steven G Grinnell, Melissa N Nelson, Amy H Newman, Lutz Birnbaumer, Kirill A Martemyanov, Jonathan A Javitch, Christopher P Ford
Dopamine input to the dorsal and ventral striatum originates from separate populations of midbrain neurons. Despite differences in afferent inputs and behavioral output, little is known about how dopamine release is encoded by dopamine receptors on medium spiny neurons (MSNs) across striatal subregions. Here we examined the activation of D2 receptors following the synaptic release of dopamine in the dorsal striatum (DStr) and nucleus accumbens (NAc) shell. We found that D2 receptor-mediated synaptic currents were slower in the NAc and this difference occurred at the level of D2-receptor signaling...
April 10, 2018: Neuron
https://www.readbyqxmd.com/read/29648626/regulation-of-intracellular-triiodothyronine-is-essential-for-optimal-macrophage-function
#10
Anne H van der Spek, Olga V Surovtseva, Kin Ki Jim, Adri van Oudenaren, Matthijs C Brouwer, Christina M J E Vandenbroucke-Grauls, Pieter J M Leenen, Diederik van de Beek, Arturo Hernandez, Eric Fliers, Anita Boelen
Innate immune cells, including macrophages, have recently been identified as novel target cells for thyroid hormone. We hypothesized that optimal intracellular concentrations of the active thyroid hormone triiodothyronine (T3) are essential for pro-inflammatory macrophage function. T3 is generated intracellularly by type 2 deiodinase (D2) and acts via the nuclear thyroid hormone receptor (TR). In zebrafish embryos, D2 knockdown increased mortality during pneumococcal meningitis. Primary murine D2KO macrophages exhibited impaired phagocytosis and partially reduced cytokine response to stimulation with bacterial endotoxin...
April 10, 2018: Endocrinology
https://www.readbyqxmd.com/read/29644470/ruthenium-ii-n-alkyl-phenothiazine-complexes-as-potential-anticancer-agents
#11
Andreja Leskovac, Sandra Petrovic, Tamara Lazarevic-Pasti, Milena Krstic, Vesna Vasic
In recent years, the search for effective anticancer compounds based on transition metal complexes has been the focus of medical investigations. The synergy between the ruthenium(II) and N-alkylphenothiazine counter-ions (chlorpromazine hydrochloride, thioridazine hydrochloride and trifluoperazine dihydrochloride, respectively) through the formation of three different complexes (1-3) was investigated. We explored whether the selected counter-ions and complexes might affect redox homeostasis and genome integrity of normal human blood cells, and induce an inhibition of Na+ /K+ -ATPase and AChE at pharmacologically relevant doses...
April 11, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29643379/publisher-correction-role-of-dopamine-d2-receptor-in-stress-induced-myelin-loss
#12
Mi-Hyun Choi, Ji Eun Na, Ye Ran Yoon, Hyo Jin Lee, Sehyoun Yoon, Im Joo Rhyu, Ja-Hyun Baik
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29627696/effects-of-the-141c-insertion-deletion-polymorphism-in-the-dopamine-d2-receptor-gene-on-the-dopamine-system-in-the-striatum-in-patients-with-schizophrenia
#13
Junya Matsumoto, Atsuko Nagaoka, Yasuto Kunii, Itaru Miura, Mizuki Hino, Shin-Ichi Niwa, Hiroyuki Nawa, Hitoshi Takahashi, Akiyoshi Kakita, Hirooki Yabe
The relationships between -141C insertion/deletion (Ins/Del) polymorphisms in the dopamine D2 receptor gene and the two dopamine system integrators, i.e., dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32) and calcineurin (CaN), are still unclear. In this study, we assessed the effect of this polymorphism on DARPP-32 and CaN protein expression in the postmortem striatum of patients with schizophrenia and control individuals. The expression levels of truncated DARPP and CaN were lower in Del allele carriers...
March 29, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29620250/poligoni-multiflori-radix-enhances-osteoblast-formation-and-reduces-osteoclast-differentiation
#14
Sang-Yong Han, Kyung-Hee Lee, Yun-Kyung Kim
Poligoni Multiflori Radix (PMR) is a traditional Korean medicinal herb that is known to have various pharmacological effects, including antihyperlipidemic, anticancer, and anti‑inflammatory effects. However, the effects of PMR on bone metabolism have not been elucidated to date. The present study aimed to investigate the in vitro and in vivo effect of PMR water extract on the regulation of osteoblast and osteoclast activity. Effects of PMR water extract on receptor activator of nuclear factor‑kB ligand (RANKL)‑induced osteoclast differentiation and survival of mouse bone marrow macrophages (BMMs) obtained from femurs were investigated by tartrate‑acid resistant acid phosphatase (TRAP)‑positive cells and XTT assay...
March 30, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29616101/expression-of-cancer-associated-fibroblast-markers-in-advanced-colorectal-cancer
#15
Rie Nishishita, Satoko Morohashi, Hiroko Seino, Yunyan Wu, Tadashi Yoshizawa, Toshihiro Haga, Kensuke Saito, Kenichi Hakamada, Shinsaku Fukuda, Hiroshi Kijima
Colorectal cancer is one of the most common causes of mortality from cancer worldwide. Previous studies have demonstrated that cancer-associated fibroblasts (CAFs) promote neoangiogenesis and tumor growth for various tumors. The present study analyzed CAF markers, including α-smooth muscle actin (α-SMA), collagen I, platelet-derived growth factor receptor-β (PDGFR-β), and D2-40 (antibody recognizing podoplanin), and vessel markers, including cluster of differentiation (CD)31 and CD34, for 121 advanced colorectal cancer cases using a digital image analyzing technique...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29615922/sensory-processing-and-integration-at-the-carotid-body-tripartite-synapse-neurotransmitter-functions-and-effects-of-chronic-hypoxia
#16
REVIEW
Erin M Leonard, Shaima Salman, Colin A Nurse
Maintenance of homeostasis in the respiratory and cardiovascular systems depends on reflexes that are initiated at specialized peripheral chemoreceptors that sense changes in the chemical composition of arterial blood. In mammals, the bilaterally-paired carotid bodies (CBs) are the main peripheral chemoreceptor organs that are richly vascularized and are strategically located at the carotid bifurcation. The CBs contribute to the maintenance of O2 , CO2 /H+ , and glucose homeostasis and have attracted much clinical interest because hyperactivity in these organs is associated with several pathophysiological conditions including sleep apnea, obstructive lung disease, heart failure, hypertension, and diabetes...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29615894/trpc1-deletion-causes-striatal-neuronal-cell-apoptosis-and-proteomic-alterations-in-mice
#17
Dian Wang, Haitao Yu, Benhong Xu, Hua Xu, Zaijun Zhang, Xiaohu Ren, Jianhui Yuan, Jianjun Liu, Yi Guo, Peter S Spencer, Xifei Yang
Transient receptor potential channel 1 (TRPC1) is widely expressed throughout the nervous system, while its biological role remains unclear. In this study, we showed that TRPC1 deletion caused striatal neuronal loss and significantly increased TUNEL-positive and 8-hydroxy-2'-deoxyguanosine (8-OHdG) staining in the striatum. Proteomic analysis by two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) coupled with mass spectrometry (MS) revealed a total of 51 differentially expressed proteins (26 increased and 25 decreased) in the stratum of TRPC1 knockout (TRPC1-/- ) mice compared to that of wild type (WT) mice...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29615863/the-d2-dopamine-receptor-interferes-with-the-protective-effect-of-the-a-2a-adenosine-receptor-on-tdp-43-mislocalization-in-experimental-models-of-motor-neuron-degeneration
#18
Chia-You Lai, Yu-Ju Liu, Hsing-Lin Lai, Hui-Mei Chen, Hung-Chi Kuo, Yu-Ping Liao, Yijuang Chern
The A2A adenosine receptor (A2A R) and D2 dopamine receptor (D2 R) are two G-protein-coupled receptors that can form dimers and negatively regulate their partners. TAR DNA-binding protein (TDP-43) is a nuclear protein that has been implicated in amyotrophic lateral sclerosis (ALS). Mislocalization of TDP-43 from the nucleus to the cytoplasm is an early step of TDP-43 proteinopathy. Our previous studies indicated that A2A R is a potential drug target for ALS because treatment with an A2A R agonist (JMF1907; a T1-11 analog) prevents reactive oxygen species (ROS)-induced TDP-43 mislocalization in a motor neuron cell line (NSC34) and delays motor impairment in a TDP-43 transgenic ALS mouse model...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29611323/leptin-attenuates-d-2-receptor-mediated-inhibition-of-putative-ventral-tegmental-area-dopaminergic-neurons
#19
Takami Murakami, Munechika Enjoji, Susumu Koyama
Obesity causes hyperleptinemia. We have previously shown that D2 receptor-mediated inhibition of ventral tegmental area (VTA) dopaminergic neurons is attenuated in diet-induced mice with obesity. Consequently, we hypothesized that high concentrations of serum leptin during obesity might modulate D2 receptor-mediated effects on VTA dopaminergic neurons. To investigate our hypothesis, we examined leptin effects on D2 receptor-mediated inhibition of putative VTA dopaminergic neurons from lean mice using electrophysiological techniques...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29607536/dp1-receptor-signaling-prevents-the-onset-of-intrinsic-apoptosis-in-eosinophils-and-functions-as-a-transcriptional-modulator
#20
Miriam Peinhaupt, David Roula, Anna Theiler, Miriam Sedej, Rudolf Schicho, Gunther Marsche, Eva M Sturm, Ian Sabroe, Marc E Rothenberg, Akos Heinemann
Prostaglandin (PG) D2 is the ligand for the G-protein coupled receptors DP1 (D-type prostanoid receptor 1) and DP2 (also known as chemoattractant receptor homologous molecule, expressed on Th2 cells; CRTH2). Both, DP1 and DP2 are expressed on the cellular surface of eosinophils; although it has become quite clear that PGD2 induces eosinophil migration mainly via DP2 receptors, the role of DP1 in eosinophil responses has remained elusive. In this study, we addressed how DP1 receptor signaling complements the pro-inflammatory effects of DP2...
April 1, 2018: Journal of Leukocyte Biology
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