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https://www.readbyqxmd.com/read/29444518/effects-of-environmental-enrichment-on-nicotine-sensitization-in-rats-neonatally-treated-with-quinpirole-analyses-of-glial-cell-line-derived-neurotrophic-factor-and-implications-towards-schizophrenia
#1
Russell W Brown, Marjorie A Schlitt, Alex S Owens, Caitlynn C DePreter, Elizabeth D Cummins, Seth L Kirby, W Drew Gill, Katherine C Burgess
The current study analyzed the effects of environmental enrichment versus isolation housing on the behavioral sensitization to nicotine in the neonatal quinpirole (NQ; dopamine D2-like agonist) model of dopamine D2 receptor supersensitivity, a rodent model of schizophrenia. NQ treatment in rats increases dopamine D2 receptor sensitivity throughout the animal's lifetime, consistent with schizophrenia. Animals were administered NQ (1 mg/kg) or saline (NS) from postnatal day (P)1 to P21, weaned, and immediately placed into enriched housing or isolated in wire cages throughout the experiment...
February 14, 2018: Developmental Neuroscience
https://www.readbyqxmd.com/read/29441778/nickel-catalyzed-phosphine-free-direct-n-alkylation-of-amides-with-alcohols
#2
Jagadish Das, Debasis Banerjee
Herein, we developed an operational simple, practical and selective Ni-catalyzed synthesis of secondary amides. Application of renewable alcohols, earth-abundant and non-precious nickel catalyst enable the transformations, releasing water as by product. The catalytic system is tolerant to variety of functional groups including nitrile, allylic ether and alkene and could be extended to the synthesis of bis-amide, antiemetic drug Tigan and dopamine D2 receptor antagonist Itopride. Preliminary mechanistic studies, revealed the participation of benzylic C-H bond in the rate-determining step...
February 14, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29440639/the-small-gtpase-rhou-lays-downstream-of-jak-stat-signaling-and-mediates-cell-migration-in-multiple-myeloma
#3
Sara Canovas Nunes, Martina Manzoni, Marco Pizzi, Elisa Mandato, Marilena Carrino, Laura Quotti Tubi, Renato Zambello, Fausto Adami, Andrea Visentin, Gregorio Barilà, Livio Trentin, Sabrina Manni, Antonino Neri, Gianpietro Semenzato, Francesco Piazza
Multiple myeloma is a post-germinal center B-cell neoplasm, characterized by the proliferation of malignant bone marrow plasma cells, whose survival and proliferation is sustained by growth factors and cytokines present in the bone marrow microenvironment. Among them, IL-6 triggers the signal downstream of its receptor, leading to the activation of the JAK/STAT pathway. The atypical GTPase RhoU lays downstream of STAT3 transcription factor and could be responsible for mediating its effects on cytoskeleton dynamics...
February 13, 2018: Blood Cancer Journal
https://www.readbyqxmd.com/read/29439730/resolvin-d2-protects-against-cerebral-ischemia-reperfusion-injury-in-rats
#4
Gang Zuo, Dongping Zhang, Rutao Mu, Haitao Shen, Xiang Li, Zhong Wang, Haiying Li, Gang Chen
Cerebral ischemia/reperfusion (I/R) injury is a critical factor leading to a poor prognosis for ischemic stroke patients. ω-3 fatty acid supplements taken as part of a daily diet have been shown to improve the prognosis of patients with ischemic stroke. In this study, we aimed to investigate the potential effects of resolvin D2 (RvD2), a derivative of ω-3 fatty acids, and its possible advantage on cerebral I/R injury in rats. Cerebral I/R caused by middle cerebral artery occlusion and reperfusion (MCAO/R) was established in Sprague-Dawley rats...
February 13, 2018: Molecular Brain
https://www.readbyqxmd.com/read/29439547/prostaglandin-d2-mediated-dp2-and-akt-signal-regulate-the-activation-of-androgen-receptors-in-human-dermal-papilla-cells
#5
Kwan Ho Jeong, Ji Hee Jung, Jung Eun Kim, Hoon Kang
Prostaglandin D2 (PGD2) and prostaglandin D2 receptor 2 (DP2) is known to be an important factor in androgenetic alopecia (AGA). However, the effect of PGD2 in human dermal papilla cells (hDPCs) is not fully understood. The function of PGD2-induced expression of the androgen receptor (AR), DP2, and AKT (protein kinase B) signal were examined by using real time-PCR (qRT-PCR), western blot analysis, immunocytochemistry (ICC), and siRNA transfection system. PGD2 stimulated AR expression and AKT signaling through DP2...
February 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29439093/dysregulated-genes-and-their-functional-pathways-in-luteinized-granulosa-cells-from-pcos-patients-after-cabergoline-treatment
#6
Hortensia Ferrero, Patricia Diaz-Gimeno, Patricia Sebastian-Leon, Amparo Faus, Raul Gómez, Antonio Pellicer
Polycystic ovarian syndrome (PCOS) is a common reproductive disorder frequently associated with a substantial risk factor for ovarian hyperstimulation syndrome (OHSS). Dopamine receptor 2 (D2) agonists, like Cabergoline (Cb2), have been used to reduce the OHSS risk. However, lutein granulosa cells (LGCs) from PCOS patients treated with Cb2 still show a deregulated dopaminergic tone (decreased D2 expression and low dopamine production) and increased vascularization compared to non-PCOS LGCs. Therefore, to understand the PCOS ovarian physiology, it is important to explore the mechanisms that underlie syndrome based on the therapeutic effects of Cb2...
February 9, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29434188/dopamine-d2-receptor-mediated-neuroprotection-in-a-g2019s-lrrk2-genetic-model-of-parkinson-s-disease
#7
Alessandro Tozzi, Michela Tantucci, Saverio Marchi, Petra Mazzocchetti, Michele Morari, Paolo Pinton, Andrea Mancini, Paolo Calabresi
Parkinson's disease (PD) is a neurodegenerative disorder in which genetic and environmental factors synergistically lead to loss of midbrain dopamine (DA) neurons. Mutation of leucine-rich repeated kinase2 (Lrrk2) genes is responsible for the majority of inherited familial cases of PD and can also be found in sporadic cases. The pathophysiological role of this kinase has to be fully understood yet. Hyperactivation of Lrrk2 kinase domain might represent a predisposing factor for both enhanced striatal glutamatergic release and mitochondrial vulnerability to environmental factors that are observed in PD...
February 12, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29432603/in-vitro-screening-for-seizure-liability-using-microelectrode-array-technology
#8
Jenifer A Bradley, Harry H Luithardt, Monica R Metea, Christopher J Strock
Drug induced seizure liabilities produce significant compound attrition during drug discovery. Currently available in vitro cytotoxicity assays cannot predict all toxicity mechanisms due to the failure of these assays to predict sublethal target specific electrophysiological liabilities. Identification of seizurogenic and other electrophysiological effects at early stages of the drug development process is important to ensure that safe candidate compounds can be developed while chemical design is taking place, long before these liabilities are discovered in costly preclinical in vivo studies...
February 8, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29432503/therapeutic-drug-monitoring-of-atypical-antipsychotics
#9
REVIEW
Anna Emilia Urban, Wiesław Jerzy Cubała
The paper presents an overview and analysis of the results of research on therapeutic ranges of concentrations and receptor occupancy, mainly D2 receptors, in the treatment with some atypical antipsychotic drugs. Amisulpride, aripiprazole, clozapine, quetiapine, olanzapine, risperidone, paliperidone, sertindole, and ziprasidone were taken into account. The benefits of therapeutic drug monitoring to optimize the effectiveness of treatment and avoid side effects or toxicity were shown. The safety of patients, with the possibility to use the lowest effective dose, is an undoubted profit of TDM...
December 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29432300/dopamine-modulates-striatal-response-to-reward-and-punishment-in-patients-with-parkinson-s-disease-a-pharmacological-challenge-fmri-study
#10
Miklos Argyelan, Mohammad Herzallah, Wataru Sako, Ivana DeLucia, Deepak Sarpal, An Vo, Toni Fitzpatrick, Ahmed A Moustafa, David Eidelberg, Mark Gluck
It is well established that Parkinson's disease leads to impaired learning from reward and enhanced learning from punishment. The administration of dopaminergic medications reverses this learning pattern. However, few studies have investigated the neural underpinnings of these cognitive processes. In this study, using fMRI, we tested a group of Parkinson's disease patients on and off dopaminergic medications and matched healthy individuals. All individuals completed an fMRI cognitive task that dissociates feedback learning from reward versus punishment...
February 9, 2018: Neuroreport
https://www.readbyqxmd.com/read/29431143/effects-of-prophylactic-anticholinergic-medications-to-decrease-extrapyramidal-side-effects-in-patients-taking-acute-antiemetic-drugs-a-systematic-review-and-meta-analysis
#11
Ryan S D'Souza, Christopher Mercogliano, Elizabeth Ojukwu, Shawn D'Souza, Andrew Singles, Jaymin Modi, Alexandra Short, Anthony Donato
OBJECTIVES: To determine the effectiveness of prophylactic anticholinergic medications in reducing extrapyramidal symptoms in patients taking acute antiemetics with a dopamine D2 receptor antagonist effect. METHODS: Systematic searches of all published studies through March 2017 were identified from PubMed, Cochrane library, Embase, Web of Science and Scopus. Only randomised controlled trials of patients receiving dopamine D2 antagonist antiemetic therapy for acute migraine in which an anticholinergic or placebo was compared were included...
February 3, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29429048/peptide-yy-causes-apathy-like-behavior-via-the-dopamine-d2-receptor-in-repeated-water-immersed-mice
#12
Chihiro Yamada, Sachiko Mogami, Hitomi Kanno, Tomohisa Hattori
Apathy is observed across several neurological and psychiatric conditions; however, its pathogenesis remains unclear. We clarified the involvement of brain-gut signaling in the disruption of goal-directed behavior. Male C57BL/6J mice were exposed to water immersion (WI) stress for 3 days. Food intake and nesting behavior were measured as indexes of motivation. Repeated WI caused decrease in food intake and nesting behavior. Plasma levels of peptide YY (PYY), IL-6, and ratio of dopamine metabolites in the striatum were significantly elevated after WI...
February 10, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29427922/psychotomimetic-like-behavioral-effects-of-memantine-in-the-mouse
#13
Nobue Kitanaka, Junichi Kitanaka, F Scott Hall, Yoshiro Kubota, Yumi Mimura, Sayaka Ogura, Yukiya Okada, George R Uhl, Motohiko Takemura
A single administration of mice with memantine (1-amino-3,5-dimethyladamantane), a glutamatergic N-methyl-d-aspartate (NMDA) receptor antagonist, induced stereotyped behaviors in dose- and time-dependent manners. The predominant behavioral component of the stereotypy was a continuous, exaggerated sniffing which was accompanied by persistent locomotion. In contrast, a psychostimulant methamphetamine (METH) predominantly induced a stereotyped biting and other forms of intense stationary stereotypical behaviors...
February 7, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29427081/effects-of-tolcapone-and-bromocriptine-on-cognitive-stability-and-flexibility
#14
Ian G M Cameron, Deanna L Wallace, Ahmad Al-Zughoul, Andrew S Kayser, Mark D'Esposito
RATIONALE: The prefrontal cortex (PFC) and basal ganglia (BG) have been associated with cognitive stability and cognitive flexibility, respectively. We hypothesized that increasing PFC dopamine tone by administering tolcapone (a catechol-O-methyltransferase (COMT) inhibitor) to human subjects should promote stability; conversely, increasing BG dopamine tone by administering bromocriptine (a D2 receptor agonist) should promote flexibility. OBJECTIVE: We assessed these hypotheses by administering tolcapone, bromocriptine, and a placebo to healthy subjects who performed a saccadic eye movement task requiring stability and flexibility...
February 9, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29423959/low-resilience-to-stress-is-associated-with-candidate-gene-expression-alterations-in-the-dopaminergic-signalling-pathway
#15
Esfandiar Azadmarzabadi, Arvin Haghighatfard, Alireza Mohammadi
BACKGROUND: In stressful situations, a person's ability to appropriately complete tasks with minimal anxiety is known as stress resilience. Genetic variants in neuropeptide Y, Corticotropin releasing hormone receptor 1 (CRHR1), and serotonin transporter have been previously reported to be associated with low resilience, but the relationship between low resilience and the dopaminergic signalling pathway is not well understood. Here, we aimed to describe the association between comprehensive psychological characteristics and messenger RNA levels of dopamine receptor D1 (DRD1), dopamine receptor D2 (DRD2), dopamine receptor D3 (DRD3), dopamine receptor D4 (DRD4), dopamine receptor D5 (DRD5), COMT, Dopamine Beta-Hydroxylase (DBH), Tyrosine hydroxylase (TH), monoamine oxidase A (MAOM), dopa decarboxylase (DDC), dopamine transporter (DAT), serotonin transporter (5-HTT), brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) genes based on peripheral blood samples from 400 subjects who react differently to major life event stressors...
February 8, 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/29423319/improvement-of-long-term-memory-access-with-a-pro-dopamine-regulator-in-an-elderly-male-are-we-targeting-dopamine-tone
#16
Thomas McLaughlin, David Han, James Nicholson, Bruce Steinberg, Kenneth Blum, Marcelo Febo, Eric Braverman, Mona Li, Lyle Fried, Rajendra Badgaiyan
With aging, there is decline in both short-term and long-term memory. This effect is magnified by epigenetic insults on specific, dopamine- related genes (e.g., DRD2, DAT1) as well as by impaired or reduced mRNA transcription. In addition, long-term memory ability is positively correlated with dopamine function and there is evidence that aging is associated with a reduction in brain dopamine D2 receptors, with an acceleration seen in aging-induced dementia. As a result, the authors tested the acute effect of a Pro-Dopamine Regulator (KB220Z, liquid Nano variant) on an aspect of long-term memory performance in a 77-year-old, highly functional male, using the Animal Naming Test (ANT)...
May 2017: Journal of Systems and Integrative Neuroscience
https://www.readbyqxmd.com/read/29421751/veterinary-drug-17%C3%AE-trenbolone-promotes-the-proliferation-of-human-prostate-cancer-cell-line-through-the-akt-ar-signaling-pathway
#17
Hee-Seok Lee, Da-Woon Jung, Songyi Han, Hui-Seung Kang, Jin-Hyang Suh, Hyun-Suk Oh, Myung-Sil Hwang, Guiim Moon, Yooheon Park, Jin-Hwan Hong, Yong Eui Koo
Trenbolone acetate (TBA) is a synthetic anabolic steroidal growth factor that is used for rapid muscle development in cattle. The absorbed TBA is hydrolyzed to the active form, 17β-trenbolone (17 TB; 17β-hydroxy-estra-4,9,11-trien-3-one) in meat and milk products, which can cause adverse health effects in humans. Similar to 5α-dihydrotestosterone (DHT), 17 TB was reported to exhibit endocrine disrupting effects on animals and humans due to its androgenic effect via binding to the androgen receptor. The purpose of this study is to investigate the molecular mechanism of cell proliferation in prostate cancer (PCa) cells treated with 17 TB...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29421436/dopamine-noradrenaline-and-serotonin-receptor-densities-in-the-striatum-of-hemiparkinsonian-rats-following-botulinum-neurotoxin-a-injection
#18
T Mann, K Zilles, H Dikow, A Hellfritsch, M Cremer, M Piel, F Rösch, A Hawlitschka, O Schmitt, A Wree
Parkinson's disease (PD) is characterized by a degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) that causes a dopamine (DA) deficit in the caudate-putamen (CPu) accompanied by compensatory changes in other neurotransmitter systems. These changes result in severe motor and non-motor symptoms. To disclose the role of various receptor binding sites for DA, noradrenaline, and serotonin in the hemiparkinsonian (hemi-PD) rat model induced by unilateral 6-hydroxydopamine (6-OHDA) injection, the densities of D1, D2/D3, α 1, α 2, and 5HT2A receptors were longitudinally visualized and measured in the CPu of hemi-PD rats by quantitative in vitro receptor autoradiography...
February 5, 2018: Neuroscience
https://www.readbyqxmd.com/read/29421337/role-of-d1-and-d2-like-dopaminergic-receptors-in-the-nucleus-accumbens-in-modulation-of-formalin-induced-orofacial-pain-involvement-of-lateral-hypothalamus
#19
Iman Shafiei, Mahsaneh Vatankhah, Leila Zarepour, Somayeh Ezzatpanah, Abbas Haghparast
The role of dopaminergic system in modulation of formalin-induced orofacial nociception has been established. The present study aims to investigate the role of dopaminergic receptors in the nucleus accumbens (NAc) in modulation of nociceptive responses induced by formalin injection in the orofacial region. One hundred and six male Wistar rats were unilaterally implanted with two cannulae into the lateral hypothalamus (LH) and NAc. Intra-LH microinjection of carbachol, a cholinergic receptor agonist, was done 5min after intra-accumbal administration of different doses of SCH23390 (D1-like receptor antagonist) or sulpiride (D2-like receptor antagonist)...
January 29, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29417763/combined-treatment-with-a-selective-pde10a-inhibitor-tak-063-and-either-haloperidol-or-olanzapine-at-subeffective-doses-produces-potent-antipsychotic-like-effects-without-affecting-plasma-prolactin-levels-and-cataleptic-responses-in-rodents
#20
Kazunori Suzuki, Akina Harada, Hirobumi Suzuki, Clizia Capuani, Annarosa Ugolini, Mauro Corsi, Haruhide Kimura
Activation of indirect pathway medium spiny neurons (MSNs) via promotion of cAMP production is the principal mechanism of action of current antipsychotics with dopamine D2 receptor antagonism. TAK-063 [1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one] is a novel phosphodiesterase 10A inhibitor that activates both direct and indirect pathway MSNs through increasing both cAMP and cGMP levels by inhibition of their degradation. The activation of indirect pathway MSNs through the distinct mechanism of action of these drugs raises the possibility of augmented pharmacological effects by combination therapy...
February 2018: Pharmacology Research & Perspectives
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