Sarwat Amna, Thomas Øhlenschlaeger, Eva Aggerholm Saedder, Jarl Voss Sigaard, Troels Korshøj Bergmann
Clonidine is an α-adrenoceptor agonist acting on receptors in the brain and peripheral tissues, leading to a reduction in sympathetic outflow and release of certain neurotransmitters. Clonidine has multiple uses across various medical conditions. One of its uses is as adjuvant to anaesthetic and analgesic agents specially opioids, mostly administered through intravenous and epidural routes. The opioids, effective in cancer pain management, are associated with various side effects such as sedation, pruritus, constipation, nausea, respiratory depression, tolerance and dependence...
January 26, 2024: Basic & Clinical Pharmacology & Toxicology