Nikolina Basić-Jukić, Ivana Jurić, Petar Kes, Ljubica Bubić-Filipi, Bruna Brunetta, Josip Pasini
Arterial hypertension develops in up to 80% of renal transplant recipients. Uncontrolled hypertension induces left ventricular hypertrophy, heart failure and death, but also promotes deterioration of allograft function. Cadaveric transplantation, delayed graft function, renal artery stenosis, presence of native kidneys, increased body weight and therapy with calcineurin inhibitors and steroids have been associated with an increased incidence of hypertension after kidney transplantation. Cyclosporine increases both systemic and renal vascular resistance, enhances sympathetic activation, endothelin production and, possibly, decreases vascular relaxation by decreasing the generation of nitric oxide...
April 2007: Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti