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https://www.readbyqxmd.com/read/27384690/rare-case-of-nephrocalcinosis-in-a-14-year-old-girl-questions
#1
Omar Bjanid, Piotr Adamczyk, Małgorzata Stojewska, Dagmara Roszkowska-Bjanid, Magdalena Paszyna-Grześkowiak, Agnieszka Jędzura, Joanna Oświęcimska, Katarzyna Ziora, Aurelia Morawiec-Knysak, Maria Szczepańska
A 14-year-old Caucasian girl with a history of primary hypoparathyroidism and unstable calcium and phosphorus levels and on ongoing treatment was admitted to the Department of Pediatric Nephrology because of the onset of nephrocalcinosis and difficulties achieving normocalcemia. Coexistence of hypoparathyroidism, oral candidiasis, dental enamel hypoplasia, and subclinical Hashimoto's disease was strongly suggestive for autoimmune polyglandular syndrome (APS) type I. One of the clinical implications of this diagnosis is the high probability of future occurrence of adrenal insufficiency and hence the importance of maintaining a high level of suspicion in case of the onset of symptoms like weakness, fainting, hypotonia, or hyperkaliemia...
July 6, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27369102/-gordon-syndrome-the-importance-of-measuring-blood-pressure-in-children
#2
A Bruel, R Vargas-Poussou, X Jeunemaitre, A Labbe, E Merlin, L Bessenay
Gordon's syndrome, or type II pseudo-hypoaldosteronism, is a rare cause of arterial hypertension in children. However, it is important to diagnose this syndrome because of the spectacular efficacy of thiazide diuretics. The typical clinical picture of Gordon syndrome includes, apart from arterial hypertension and dyskaliemia, hyperchloremia metabolic acidosis, hypercalciuria, a low rate of renin, and most frequently, a normal or high rate of aldosterone. Dental abnormalities and growth retardation can also be associated...
August 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27115525/finerenone-a-new-mineralocorticoid-receptor-antagonist-without-hyperkalemia-an-opportunity-in-patients-with-ckd
#3
REVIEW
Hermann Haller, Anna Bertram, Klaus Stahl, Jan Menne
Aldosterone binds to the mineralocorticoid receptor and has an important regulatory role in body fluid and electrolyte balance. It also influences a variety of different cell functions such as oxidative stress, inflammation and organ fibrosis. The important role of the tissue-specific mineralocorticoid receptors in cardiovascular and renal injury has been shown in knockout animals and in clinical studies Mineralocorticoid receptor antagonists seem to exert their beneficial effects via anti-oxidative, anti-inflammatory and anti-fibrotic effects...
April 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/26415323/coexistence-of-addison-s-disease-and-pernicious-anemia-is-the-new-classification-of-autoimmune-polyglandular-syndrome-appropriate
#4
Ana Marija Vrkljan, Ante Pašalić, Mateja Strinović, Božidar Perić, Ivan Kruljac, Gorana Miroševć
A case of autoimmune polyglandular syndrome (APS) is presented. A 45-year-old man was admitted due to fatigue, malaise and inappetence. He had a history of primary hypothyroidism and was on levothyroxine substitution therapy. One year before, he was diagnosed with normocytic anemia and vitamin B12 deficiency, which was treated with vitamin B12 substitution therapy. Physical examination revealed hypotension and marked hyperpigmentation. Laboratory testing showed hyponatremia, hyperkaliemia and severe normocytic anemia...
June 2015: Acta Clinica Croatica
https://www.readbyqxmd.com/read/25834708/late-care-in-marathon-runs-leading-to-exertional-heat-stroke-with-multiple-organ-failure
#5
Mohammed Asserraji, Ibrahim Benameur, Omar Maoujoud, Abdennasser El Kharras, Hicham Hajbi, Karim Filali
BACKGROUND: Exertional heat stroke (EHS) is still a main cause of death in sport. Many of EHS complications could have been prevented if EHS had been recognized and treated early and properly. CASE PRESENTATION: We report an unusual case of multiple organ failure caused by EHS due to intensive sportive activities in a hot environment with lack of primary care. A 35-year-old healthy sportive man was admitted in our hospital because of muscle aches and weakness as well as dark urine three days after a six hour marathon run (Agadir Semi-Marathon) in a very sunny day...
June 2014: Asian Journal of Sports Medicine
https://www.readbyqxmd.com/read/25539792/detailed-statistical-analysis-plan-for-the-pulmonary-protection-trial
#6
RANDOMIZED CONTROLLED TRIAL
Katrine B Buggeskov, Janus C Jakobsen, Niels H Secher, Thomas Jonassen, Lars W Andersen, Daniel A Steinbrüchel, Jørn Wetterslev
BACKGROUND: Pulmonary dysfunction complicates cardiac surgery that includes cardiopulmonary bypass. The pulmonary protection trial evaluates effect of pulmonary perfusion on pulmonary function in patients suffering from chronic obstructive pulmonary disease. This paper presents the statistical plan for the main publication to avoid risk of outcome reporting bias, selective reporting, and data-driven results as an update to the published design and method for the trial. RESULTS: The pulmonary protection trial is a randomized, parallel group clinical trial that assesses the effect of pulmonary perfusion with oxygenated blood or Custodiol™ HTK (histidine-tryptophan-ketoglutarate) solution versus no pulmonary perfusion in 90 chronic obstructive pulmonary disease patients...
December 23, 2014: Trials
https://www.readbyqxmd.com/read/24209502/-massive-rhabdomyolysis-an-uncommon-complication-of-cholesterol-embolization-syndrome
#7
J Mathieu, J-P Pertek, S Brua, Z Samia, M R Losser
A 79-year-old man with atherosclerosis presented blue toes and livedo reticularis. The patient had eroded aortic atheromatous plaques, and cholesterol embolization syndrome was suspected. An endovascular technique to exclude sources of cholesterol emboli was however performed. The patient immediately presented with severe muscle pain and total functional disability of lower limbs, new ischemic lesions of toes, anal and genital necrosis, and a livedo extended up to the abdomen. A massive rhabdomyolysis occurred associated with acute kidney injury and hyperkaliemia treated by continuous renal replacement therapy with regional citrate anticoagulation...
December 2013: Annales Françaises D'anesthèsie et de Rèanimation
https://www.readbyqxmd.com/read/23351185/predictive-factors-of-adrenal-insufficiency-in-patients-admitted-to-acute-medical-wards-a-case-control-study
#8
Jean-Baptiste Oboni, Pedro Marques-Vidal, François Pralong, Gérard Waeber
UNLABELLED: HASH(0x37778f0) BACKGROUND: Adrenal insufficiency is a rare and potentially lethal disease if untreated. Several clinical signs and biological markers are associated with glucocorticoid failure but the importance of these factors for diagnosing adrenal insufficiency is not known. In this study, we aimed to assess the prevalence of and the factors associated with adrenal insufficiency among patients admitted to an acute internal medicine ward. METHODS: Retrospective, case-control study including all patients with high-dose (250 μg) ACTH-stimulation tests for suspected adrenal insufficiency performed between 2008 and 2010 in an acute internal medicine ward (n = 281)...
2013: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/22925939/-changes-in-kaliemia-following-rapid-sequence-induction-with-succinylcholine-in-critically-ill-patients
#9
F Mégret, V Perrier, C Fleureau, A Germain, A Dewitte, H Rozé, A Ouattara
OBJECTIVE: Evaluate the changes in potassium following rapid sequence induction with succinylcholine in critically ill-patients and determine whether hospital length of stay could influence the succinylcholine-induced hyperkaliemia. STUDY DESIGN: Prospective and observational study. PATIENTS AND METHODS: After approval by our local ethical committee, we prospectively included 36 patients admitted from more than 24hours in ICU and who required succinylcholine for rapid tracheal intubation (1mg/kg)...
October 2012: Annales Françaises D'anesthèsie et de Rèanimation
https://www.readbyqxmd.com/read/22142051/intraoperative-hyperkaliemia-complicating-hand-assisted-live-donor-nephrectomy
#10
David van Dellen, Afshin Tavakoli, Richard Wadsworth, Titus Augustine
OBJECTIVES: Live donation has become increasingly valuable as a potential source of kidneys for transplant with hand-assisted laparoscopic donation is an important method of organ procurement. An important consideration is adequate preoperative and intraoperative planning, and precautions to minimize potential risks in the donor while providing a graft with good primary function. MATERIALS AND METHODS: We present a case of live donation in which a hand-assisted laparoscopic approach was used to facilitate kidney donation...
December 2011: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/21879662/preoperative-assessment-of-patients-with-end-stage-renal-failure
#11
REVIEW
Nebojsa Ladjević, Nevena Kalezić, Ivana Likić Ladjević, Aleksandar Vuksanović, Otas Durutović, Dijana Jovanović
Patients with end stage renal failure (ESRF) present a number of challenges to the anesthesiologist. They may be chronically ill and debilitated and have the potential for multisystem organ dysfunction. Patients with primary renal disease are likely younger and have good cardiopulmonary reserve. Older patients with renal failure secondary to diabetes mellitus or hypertension may suffer the ravages of diffuse atherosclerosis and heart disease. To safely manage these patients we need to understand the benefits and limitations of dialysis, problems related with primary disease, pathophysiological effects of ESRF, and the altered pharmacology of commonly used anesthetic agents and perioperative medications in ESRF...
2011: Acta Chirurgica Iugoslavica
https://www.readbyqxmd.com/read/21719239/-sugammadex-and-renal-failure-a-case-report
#12
M Briere, C Boisson, P Cuvillon, B Debaene, J Ripart
We report a case of delayed rocuronium-induced deep block antagonization with sugammadex, thus requiring a total of three injections and a cumulative dose of 12 mg/kg over a 30 min period. The patient was an emergency case with full stomach that had required a rapid sequence induction. Because of hyperkaliemia due to an acute renal failure, rocuronium was preferred to succinylcholine. Use of sugammadex in the acute renal failure context is discussed.
October 2011: Annales Françaises D'anesthèsie et de Rèanimation
https://www.readbyqxmd.com/read/21125214/-comments-on-the-2010-guidelines-on-cardiopulmonary-resuscitation-of-the-european-resuscitation-council
#13
V Wenzel, S G Russo, H R Arntz, J Bahr, M A Baubin, B W Böttiger, B Dirks, U Kreimeier, M Fries, C Eich
ADULTS: Administer chest compressions (minimum 100/min, minimum 5 cm depth) at a ratio of 30:2 with ventilation (tidal volume 500-600 ml, inspiration time 1 s, F(I)O₂ if possible 1.0). Avoid any interruptions in chest compressions. After every single defibrillation attempt (initially biphasic 120-200 J, monophasic 360 J, subsequently with the respective highest energy), chest compressions are initiated again immediately for 2 min independent of the ECG rhythm. Tracheal intubation is the optimal method for securing the airway during resuscitation but should be performed only by experienced airway management providers...
December 2010: Der Anaesthesist
https://www.readbyqxmd.com/read/20204181/severe-hyperkalemia-and-bilateral-adrenal-metastasis
#14
Michael Nagler, Beat Müller, Verena Briner, Ralph Winterhalder
Adrenal metastases are a common finding in metastatic lung and breast cancer. Often there are no clinical symptoms suggesting them. In this paper, we present a case of a 66-year-old man with metastatic lung cancer suffering from severe hyperkaliemia due to hypoaldosteronism as a result of bilateral adrenal metastasis.
2009: Journal of Oncology
https://www.readbyqxmd.com/read/19877558/-acute-glyphosate-surfactant-poisoning-with-neurological-sequels-and-fatal-outcome
#15
Olivera Potrebić, Jasmina Jović-Stosić, Slavica Vucinić, Jelena Tadić, Misel Radulac
INTRODUCTION: Clinical picture of severe glyphosate-surfactant poisoning is manifested by gastroenteritis, respiratory disturbances, altered mental status, hypotension refractory to the treatment, renal failure, shock. Single case report indicated possible neurotoxic sequels of glyphosate-surfactant exposure with white matter lesions and development of Parkinsonism. We described a patient with massive white matter damage which led to vigil coma and lethal outcome. CASE REPORT: A 56-year old woman ingested about 500 mL of herbicide containing glyphosate isopropylamine salt...
September 2009: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
https://www.readbyqxmd.com/read/19591858/double-lethal-coconut-crab-birgus-latro-l-poisoning
#16
C Maillaud, S Lefebvre, C Sebat, Y Barguil, P Cabalion, M Cheze, E Hnawia, M Nour, F Durand
We report a double lethal coconut crab Birgus latro L. poisoning in New Caledonia. Both patients died after showing gastro-intestinal symptoms, major bradycardia with marked low blood pressure, and finally asystolia. Both had significative hyperkaliemia, suggesting a digitaline-like substance intoxication. Traditional knowledge in the Loyalty Islands relates coconut crab toxicity to the consumption of the Cerbera manghas fruit by the crustacean. Elsewhere previous descriptions of human poisoning with the kernel of fruits of trees belonging to the genus Cerbera, known to contain cardiotoxic cardenolides, appear to be very similar to our cases...
January 2010: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/19246065/-non-specific-treatment-of-status-epilepticus
#17
REVIEW
N Engrand, S Demeret, D Savary, B Clair
The systemic consequences of status epilepticus occur in two stages: the first stage is a hyperadrenergic period (high blood pressure, tachycardia, arrhythmia, hyperventilation, hypermetabolism, hyperthermia), the second stage a collapsus period, sometimes with acute circulatory failure, and hypoxemia. Symptomatic resuscitation aimed at restoring vital functions should be undertaken. Resuscitation must be started immediately before hospital transfer, by a trained emergency team. Respiratory care includes at least oxygen intake, but it can also require oral intubation (crash induction) and mechanical ventilation...
April 2009: Revue Neurologique
https://www.readbyqxmd.com/read/19019496/-hyperkalemia-induced-by-atenolol
#18
H Kassem, C Hajjar, T El Gharbi, L Turner
We report a 53-year-old woman with hyperkaliemia secondary to treatment with atenolol. The diagnosis of atenolol induced hyperkaliemia was obtained after excluding other causes of hyperkaliemia and normalization of potassium serum level following the discontinuation of this medication without any other modification (treatment or diet). Furthermore, when atenolol was again introduced, serum potassium level increased and normalized when atenol was definitively discontinued. The mechanism of hyperkaliemia we suspected is probably a reduction of potassium intracellular transfer...
August 2009: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/18619762/-sedation-and-analgesia-for-the-brain-injured-patient
#19
L Abdennour, L Puybasset
Sedation-analgesia occupies an essential place in the specific therapeutic arsenal of the brain-injured patients. The maintenance of the perfusion of the brain, its relaxation and its protection are the fundamental objectives whose finality is to avoid the extension of the lesions and to preserve the neuronal capital. Sedation is instituted when patients are severely agitated or present a deterioration of their state of consciousness (GCS< or =8). Under cover of mechanical ventilation, sedation is the first line treatment of intracranial hypertension, a common pathway of various acute brain diseases of traumatic, vascular or other origin...
July 2008: Annales Françaises D'anesthèsie et de Rèanimation
https://www.readbyqxmd.com/read/18468430/-life-threatening-drug-induced-hyperkaliemia-case-report
#20
Joanna Konopa, Barbara Bullo, Bolesław Rutkowski
Patients with congestive heart failure are at increased risk of hyperkalemia due to coexisting morbidities and usage of multiple medications that impair potassium excretion--such as angiotensin-converting enzyme inhibitors or spironolactone. Because of the risk of this disturbance, knowledge of causation and prevention is mandatory. We described 3 patients with life threatening hyperkalemia (>8.5 mEq/t) caused by drugs. We showed the symptoms of increased potassium level, the list of medications and comorbidities predisposing to hyperkalemia...
March 2006: Polskie Archiwum Medycyny Wewnętrznej
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