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https://www.readbyqxmd.com/read/28227014/random-forests-to-predict-tumor-recurrence-following-cervical-cancer-therapy-using-pre-and-per-treatment-18-f-fdg-pet-parameters
#1
Geoffrey Roman-Jimenez, Oscar Acosta, Julie Leseur, Anne Devillers, Henri Der Sarkissian, Lina Guzman, Eloi'se Grossiord, Juan-David Ospina, Renaud De Crevoisier, Geoffrey Roman-Jimenez, Oscar Acosta, Julie Leseur, Anne Devillers, Henri Der Sarkissian, Lina Guzman, Eloi'se Grossiord, Juan-David Ospina, Renaud De Crevoisier, Oscar Acosta, Julie Leseur, Juan-David Ospina, Geoffrey Roman-Jimenez, Henri Der Sarkissian, Renaud De Crevoisier, Anne Devillers, Eloise Grossiord, Lina Guzman
The ability to predict tumor recurrence after chemoradiotherapy of locally advanced cervical cancer is a crucial clinical issue to intensify the treatment of the most high-risk patients. The objective of this study was to investigate tumor metabolism characteristics extracted from pre- and per-treatment (18)F-FDG PET images to predict 3-year overall recurrence (OR). A total of 53 locally advanced cervical cancer patients underwent pre- and per-treatment (18)F-FDG PET (respectively PET1 and PET2). Tumor metabolism was characterized through several delineations using different thresholds, based on a percentage of the maximum uptake, and applied by region-growing...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225302/rapid-immunoassay-exploiting-nanoparticles-and-micromagnets-proof-of-concept-using-ovalbumin-model
#2
Sarah Delshadi, Guillaume Blaire, Paul Kauffmann, Mario Fratzl, Thibaut Devillers, Didier Delabouglise, Marianne Weidenhaupt, Nora M Dempsey, Orphée Cugat, Franz Bruckert, Patrice N Marche
AIM: We present a fast magnetic immunoassay, combining magnetic nanoparticles and micromagnets. High magnetic field gradients from micromagnets are used to develop a new approach to the standard ELISA. Materials & methods/results: A proof-of-concept based on colorimetric quantification of antiovalbumin antibody in buffer is performed and compared with an ELISA. After optimization, the magnetic immunoassay exhibits a limit of detection (40 ng/ml) and a dynamic range (40-2500 ng/ml) similar to that of ELISAs developed using same biochemical tools...
February 22, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28213450/optimal-vasodilation-protocols-the-devil-is-in-the-details
#3
EDITORIAL
Paul Knaapen
No abstract text is available yet for this article.
February 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28206794/the-devil-is-in-the-details-comparisons-of-episodic-simulations-of-positive-and-negative-future-events
#4
Vannia A Puig, Karl K Szpunar
Over the past decade, psychologists have devoted considerable attention to episodic simulation-the ability to imagine specific hypothetical events. Perhaps one of the most consistent patterns of data to emerge from this literature is that positive simulations of the future are rated as more detailed than negative simulations of the future, a pattern of results that is commonly interpreted as evidence for a positivity bias in future thinking. In the present article, we demonstrate across two experiments that negative future events are consistently simulated in more detail than positive future events when frequency of prior thinking is taken into account as a possible confounding variable and when level of detail associated with simulated events is assessed using an objective scoring criterion...
February 16, 2017: Emotion
https://www.readbyqxmd.com/read/28205368/cancer-as-a-contagious-disease
#5
REVIEW
H V Siddle
Contagious cancers are malignant cells that are physically transferred between individuals as a natural allograft, forming new clonal tumours. These cancers are highly unusual, but have emerged in 2 mammalian species, the dog and the Tasmanian devil, as well as 4 species of bivalve. The transfer of malignant cells in mammals should initiate a robust immune response and although invertebrates have a less complex immune system, these species still have mechanisms that should prevent engraftment and protect against cellular parasitism...
February 15, 2017: HLA
https://www.readbyqxmd.com/read/28187275/poisoning-the-devil
#6
Zhu Chen, Sai-Juan Chen
No abstract text is available yet for this article.
February 9, 2017: Cell
https://www.readbyqxmd.com/read/28164156/genome-wide-data-from-two-early-neolithic-east-asian-individuals-dating-to-7700-years-ago
#7
Veronika Siska, Eppie Ruth Jones, Sungwon Jeon, Youngjune Bhak, Hak-Min Kim, Yun Sung Cho, Hyunho Kim, Kyusang Lee, Elizaveta Veselovskaya, Tatiana Balueva, Marcos Gallego-Llorente, Michael Hofreiter, Daniel G Bradley, Anders Eriksson, Ron Pinhasi, Jong Bhak, Andrea Manica
Ancient genomes have revolutionized our understanding of Holocene prehistory and, particularly, the Neolithic transition in western Eurasia. In contrast, East Asia has so far received little attention, despite representing a core region at which the Neolithic transition took place independently ~3 millennia after its onset in the Near East. We report genome-wide data from two hunter-gatherers from Devil's Gate, an early Neolithic cave site (dated to ~7.7 thousand years ago) located in East Asia, on the border between Russia and Korea...
February 2017: Science Advances
https://www.readbyqxmd.com/read/28163889/ticks-and-tick-borne-diseases-in-ireland
#8
REVIEW
Annetta Zintl, Sara Moutailler, Peter Stuart, Linda Paredis, Justine Dutraive, Estelle Gonzalez, Jack O'Connor, Elodie Devillers, Barbara Good, Colm OMuireagain, Theo De Waal, Fergal Morris, Jeremy Gray
Throughout Europe interest in tick-borne agents is increasing, particularly with regard to those that can cause human disease. The reason for this is the apparent rise in the incidence of many tick-borne diseases (TBD's). While there has never been a national survey of ticks or TBD's in Ireland, the trend here appears to be the reverse with a decline in the incidence of some agents seemingly associated with decreasing tick numbers particularly on agricultural land. In the absence of robust baseline data, however, this development cannot be confirmed...
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/28161023/the-devil-is-in-the-details
#9
Samuel J Kuzminski
No abstract text is available yet for this article.
February 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28145480/attentional-deployment-impacts-neural-response-to-regret
#10
Zhiyuan Liu, Lin Li, Li Zheng, Min Xu, Fanzhi Anita Zhou, Xiuyan Guo
Regret results from comparing non-optimal outcomes containing both gain and loss parts to better alternatives during decision-making. The present fMRI study aimed to explore whether levels of regret could change when gain or loss part of a non-optimal outcome was focused during a sequential risk taking task, i.e. the effect of an important emotional regulation strategy named as attentional deployment on regret. Participants were asked to open a series of boxes consecutively and decided when to stop. Each box contained a reward, except for one containing a devil to zero one's gain in the trial...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28132863/immune-endocrine-interactions-in-marsupials-and-monotremes
#11
E Peel, K Belov
Interactions between the immune and endocrine systems are not well studied in marsupials and monotremes. One exception to this is the phenomenon of semelparity, which is well covered in the literature as this is an unusual reproductive strategy amongst mammals and is only observed in some dasyurid and didelphid marsupials. Thymus involution provides a direct link between the endocrine and immune systems and warrants further study in marsupials and monotremes. The thymus is a primary immune tissue which is essential for overall immune function...
January 27, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28127390/weird-genotypes-don-t-discard-them-transmissible-cancer-could-be-an-explanation
#12
Florentine Riquet, Alexis Simon, Nicolas Bierne
Genetic chimerism is rarely considered in the analysis of population genetics data, because assumed to be an exceptionally rare, mostly benign, developmental accident. An unappreciated source of chimerism is transmissible cancer, when malignant cells have become independent parasites and can infect other individuals. Parasitic cancers were thought to be rare exceptions, only reported in dogs (Murgia et al., Cell, 2006, 126, 477; Rebbeck et al., Evolution, 2009, 63, 2340), Tasmanian devils (Pearse and Swift, Nature, 2006, 439, 549; Pye et al...
February 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28120799/demonstration-of-immune-responses-against-devil-facial-tumour-disease-in-wild-tasmanian-devils
#13
Ruth Pye, Rodrigo Hamede, Hannah V Siddle, Alison Caldwell, Graeme W Knowles, Kate Swift, Alexandre Kreiss, Menna E Jones, A Bruce Lyons, Gregory M Woods
Devil facial tumour disease (DFTD) is a recently emerged fatal transmissible cancer decimating the wild population of Tasmanian devils (Sarcophilus harrisii). Biting transmits the cancer cells and the tumour develops in the new host as an allograft. The literature reports that immune escape mechanisms employed by DFTD inevitably result in host death. Here we present the first evidence that DFTD regression can occur and that wild devils can mount an immune response against the disease. Of the 52 devils tested, six had serum antibodies against DFTD cells and, in one case, prominent T lymphocyte infiltration in its tumour...
October 2016: Biology Letters
https://www.readbyqxmd.com/read/28114156/a-case-report-establishing-a-definitive-airway-in-a-trauma-patient-with-a-king-laryngeal-tube-in-situ-in-the-presence-of-a-closed-head-injury-and-difficult-airway-between-the-devil-and-the-deep-blue-sea
#14
Yuri Koumpan, John Murdoch, Jason A Beyea, Michael Kahn, Jaime Colbeck
Airway management in trauma is a crucial skill, because patients are at risk of aspiration, hypoxia, and hypoventilation, all of which may be fatal in the setting of increased intracranial pressure. The King Laryngeal Tube reusable supraglottic airway (King Systems, Noblesville, IN) allows for temporary management of a difficult airway but poses a challenge when an attempt is made to exchange the device for an endotracheal tube, often managed by emergency tracheostomy. We describe a novel fiberoptic, video laryngoscope-assisted approach to intubation in a difficult trauma airway with an in situ King Laryngeal Tube...
January 20, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28106392/anti-osteoporotic-activity-of-harpagoside-by-upregulation-of-the-bmp2-and-wnt-signaling-pathways-in-osteoblasts-and-suppression-of-differentiation-in-osteoclasts
#15
Hwa-Jin Chung, Won Kyung Kim, Jedo Oh, Me-Riong Kim, Joon-Shik Shin, Jinho Lee, In-Hyuk Ha, Sang Kook Lee
Harpagoside (1) is an iridoid glycoside isolated from the radix of Harpagophytum procumbens var. sublobatum, commonly called Devil's claw. The anti-osteoporotic effect of 1 was investigated in both in vitro cell cultures and in vivo using an ovariectomized (OVX) mouse model. Compound 1 induced bone formation by stimulating osteoblast proliferation, alkaline phosphatase activity, and mineralization in osteoblastic MC3T3-E1 cells. Treatment with 1 increased the mRNA and protein expression of bone formation biomarkers through regulation of the BMP2 and Wnt signaling pathway in MC3T3-E1 cells...
January 20, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28105677/lesser-devil-rays-mobula-cf-hypostoma-from-venezuela-are-almost-twice-their-previously-reported-maximum-size-and-may-be-a-new-sub-species
#16
N R Ehemann, L V González-González, A W Trites
Three rays opportunistically obtained near Margarita Island, Venezuela, were identified as lesser devil rays Mobula cf. hypostoma, but their disc widths were between 207 and 230 cm, which is almost double the reported maximum disc width of 120 cm for this species. These morphometric data suggest that lesser devil rays are either larger than previously recognized or that these specimens belong to an unknown sub-species of Mobula in the Caribbean Sea. Better data are needed to describe the distribution, phenotypic variation and population structure of this poorly known species...
January 20, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28104339/routine-corrected-qt-interval-monitoring-with-antipsychotic-use-in-consultation-liaison-setting-playing-the-devil-s-advocate
#17
EDITORIAL
Awais Aftab, Prakash Mishra, Jeanne Lackamp
No abstract text is available yet for this article.
November 11, 2016: Psychosomatics
https://www.readbyqxmd.com/read/28099446/reconstruction-of-the-cortical-maps-of-the-tasmanian-tiger-and-comparison-to-the-tasmanian-devil
#18
Gregory S Berns, Ken W S Ashwell
The last known Tasmanian tiger (Thylacinus cynocephalus)-aka the thylacine-died in 1936. Because its natural behavior was never scientifically documented, we are left to infer aspects of its behavior from museum specimens and historical recollections of bushmen. Recent advances in brain imaging have made it possible to scan postmortem specimens of a wide range of animals, even more than a decade old. Any thylacine brain, however, would be more than 100 years old. Here, we show that it is possible to reconstruct white matter tracts in two thylacine brains...
2017: PloS One
https://www.readbyqxmd.com/read/28095974/urgent-need-to-improve-pap-management-the-devil-is-in-two-fixable-details
#19
Robert Joseph Thomas, Matt Travis Bianchi
No abstract text is available yet for this article.
January 11, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28091764/isolation-of-campylobacter-spp-from-three-species-of-antarctic-penguins-in-different-geographic-locations
#20
F J García-Peña, M T Llorente, T Serrano, M J Ruano, J Belliure, J Benzal, S Herrera-León, V Vidal, V D'Amico, D Pérez-Boto, A Barbosa
The presence of Campylobacter species was studied in three Antarctic penguin species, Adélie (Pygoscelis adeliae), chinstrap (Pygoscelis antarctica) and gentoo (Pygoscelis papua). A total of 390 penguins were captured in 12 different rookeries along the Antarctic Peninsula with differences in the amount of human visitation: six colonies were highly visited [Stranger Point, King George Island (P. papua and P. adeliae); Hannah Point, Livingston Island (P. papua and P. antarctica); Deception Island (P. antarctica); and Paradise Bay, Antarctic Peninsula (P...
January 13, 2017: EcoHealth
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