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The devil

Farid Foroutan, Heather J Ross
No abstract text is available yet for this article.
May 1, 2018: Transplantation
Chelsea M Graham, Karlea L Kremer, Simon A Koblar, Monica A Hamilton-Bruce, Stephen B Pyecroft
Dental pulp stem cells (DPSC) are a heterogeneous population of highly proliferative stem cells located in the soft inner pulp tissue of the tooth. Demonstrated to have an affinity for neural differentiation, DPSC have been reported to generate functional Schwann cells (SC) through in vitro differentiation. Both DPSC and SC have neural crest origins, recently a significant population of DPSC have been reported to derive from peripheral nerve-associated glia. The predisposition DPSC have towards the SC lineage is not only a very useful tool for neural regenerative therapies in the medical field, it also holds great promise in the veterinary field...
May 8, 2018: Stem Cell Reviews
Gehendra Kharel, Andrei Kirilenko
Background: Water level fluctuations in endorheic lakes are highly susceptible to even slight changes in climate and land use. Devils Lake (DL) in North Dakota, USA is an endorheic system that has undergone multi-decade flooding driven by changes in regional climate. Flooding mitigation strategies have centered on the release of lake water to a nearby river system through artificial outlets, resulting in legal challenges and environmental concerns related to water quality, downstream flooding, species migration, stakeholder opposition, and transboundary water conflicts between the US and Canada...
2018: PeerJ
Mathieu Berthelot, Guillaume Hoffmann, Asmae Bousfiha, Julie Echaubard, Julien Roger, Hélène Cattey, Anthony Romieu, Dominique Lucas, Paul Fleurat-Lessard, Charles H Devillers
The mild (electro)chemical oxidation of pyridin-2-ylthio-meso substituted Ni(ii) porphyrins affords C-N fused cationic and dicationic pyridinium-based derivatives. These porphyrins are fully characterized and the molecular structure of one of them was confirmed by X-ray crystallography. A mechanism for the intramolecular oxidative C-N coupling is proposed based on theoretical calculations and cyclic voltammetry analyses.
May 4, 2018: Chemical Communications: Chem Comm
Sung Il Hwang, Hak Jong Lee
Purpose: The purpose of this study was to compare the diagnostic yield of five systematic randomized protocols using 12-20 biopsy cores with variably-sized phantoms. Methods: A total of 100 prostate phantom models were produced by casting liquid devil's tongue jelly using silicone molds. Sets of 20 phantoms were created with the following volumes: 20 mL, 40 mL, 60 mL, 80 mL, and 100 mL. Three focal lesions were created by injecting 0.5 mL of warm agar solution stained with red, blue, and green ink into each phantom model...
April 6, 2018: Ultrasonography
Anders Wimo
Although there have been so many failures in Alzheimer's disease (AD) modifying trials, there are still many compounds in the pipeline and the hope still remains that the entrance of disease-modifying treatment (DMT) for AD will positively and dramatically change the whole situation of AD treatment. However, if DMT does enter the market, it will be the beginning of a great number of challenges and problems. The current infrastructure for diagnostics of early (pre-dementia) AD does not have the capacity to meet the demands and expectations of the population...
April 25, 2018: Journal of Alzheimer's Disease: JAD
Cesar Tovar, Amanda L Patchett, Vitna Kim, Richard Wilson, Jocelyn Darby, A Bruce Lyons, Gregory M Woods
The Tasmanian devil (Sarcophilus harrisii), the largest extant carnivorous marsupial and endemic to Tasmania, is at the verge of extinction due to the emergence of a transmissible cancer known as devil facial tumour disease (DFTD). DFTD has spread over the distribution range of the species and has been responsible for a severe decline in the global devil population. To protect the Tasmanian devil from extinction in the wild, our group has focused on the development of a prophylactic vaccine. Although this work has shown that vaccine preparations using whole DFTD tumour cells supplemented with adjuvants can induce anti-DFTD immune responses, alternative strategies that induce stronger and more specific immune responses are required...
2018: PloS One
Jordi Puigdellivol, Carme Comellas Berenger, Miguel Ángel Pérez Fernández, Juan M Cowalinsky Millán, Christian Carreras Vidal, Inés Gil Gil, Julio Martínez Pagán, Borja Ruiz Nieto, Francisco Jiménez Gómez, Francesc X Comas Figuerola, María E Aguilar Hernández
This observational, open, multicenter clinical trial with a single treatment group aimed to evaluate the effectiveness of a dietary supplement whose main ingredients are hydrolyzed gelatin, chondroitin sulfate, glucosamine sulfate, and devil's claw and bamboo extracts for pain reduction and improvement of functional capacities in patients with osteoarthritis (OA) of the knee and/or hip (REDART study). In all, 130 patients with OA recruited from Spanish hospitals received the dietary supplement for 6 months...
April 27, 2018: Journal of Dietary Supplements
James B Whitfield, Robert J Nuelle Jr, Robert J Nuelle Iii
The braconid wasp parasitoid Cotesia nuellorum Whitfield, new species, is described from specimens reared from a caterpillar of the hickory horned devil, Citheronia regalis (F.), and from a caterpillar of the luna moth, Actias luna (L.), in eastern Texas. The species is diagnosed with respect to other species of Cotesia recorded from North American Saturniidae, and details of its biology are provided.
2018: ZooKeys
Dave Singh, Peter J Barnes, Robert Stockley, Maria Victorina Lopez Valera, Claus Vogelmeier, Alvar Agusti
No abstract text is available yet for this article.
April 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
John Roshan Jacob, Amal Paul, Anoop George Alex
A 15-year-old girl of Asian origin, hailing from a rural agrarian background, presented with history of multiple episodes of dizziness for 3 years. The episodes were precipitated mostly by emotional and/or physical stress and relieved on lying down, with a few episodes culminating in transient loss of consciousness. As preliminary cardiac and neurological evaluation were normal, she was being treated by the primary physician as a case of probable psychogenic syncope, supported by the consistent association of the episodes with emotional stress...
April 17, 2018: BMJ Case Reports
Amanda L Patchett, Richard Wilson, Jac C Charlesworth, Lynn M Corcoran, Anthony T Papenfuss, Bruce A Lyons, Gregory M Woods, Cesar Tovar
As a topical cancer immunotherapy, the toll-like receptor 7 ligand imiquimod activates tumor regression via stimulation of immune cell infiltration and cytotoxic responses. Imiquimod also exerts direct pro-apoptotic effects on tumor cells in vitro , but a role for these effects in imiquimod-induced tumor regression remains undefined. We previously demonstrated that cell lines derived from devil facial tumor disease (DFTD), a transmissible cancer threatening the survival of the Tasmanian devil ( Sarcophilus harrisii ), are sensitive to imiquimod-induced apoptosis...
March 23, 2018: Oncotarget
Jeffrey T Kullgren
No abstract text is available yet for this article.
April 16, 2018: Health Services Research
Michael J Reardon
No abstract text is available yet for this article.
March 16, 2018: Journal of Thoracic and Cardiovascular Surgery
Andrew Kneebone, Kirsten Van Gysen
In this issue, Ma and colleagues have published a provocative article assessing the burden of radiotherapy (RT) complications on a busy tertiary urology service [1]. Over a 6-month period, 21 patients contributed to 33 admissions attributed as radiotherapy complications accounting for 1.4% (13/924) of elective admissions and 7.2% (20/277) of emergency admissions. The majority were for control of bleeding but there were 4 sobering cases of major morbidity necessitating either a urinary diversion or cystoprostatectomy...
April 15, 2018: BJU International
David Alvarez-Ponce, María Torres-Sánchez, Felix Feyertag, Asmita Kulkarni, Taylen Nappi
DNA methylation is mediated by a conserved family of DNA methyltransferases (Dnmts). The human genome encodes three active Dnmts (Dnmt1, Dnmt3a and Dnmt3b), the tRNA methyltransferase Dnmt2, and the regulatory protein Dnmt3L. Despite their high degree of conservation among different species, genes encoding Dnmts have been duplicated and/or lost in multiple lineages throughout evolution, indicating that the DNA methylation machinery has some potential to undergo evolutionary change. However, little is known about the extent to which this machinery, or the methylome, varies among vertebrates...
2018: PloS One
Günther Schönrich, Martin J Raftery
Some of the clinically most important viruses persist in the human host after acute infection. In this situation, the host immune system and the viral pathogen attempt to establish an equilibrium. At best, overt disease is avoided. This attempt may fail, however, resulting in eventual loss of viral control or inadequate immune regulation. Consequently, direct virus-induced tissue damage or immunopathology may occur. The cluster of differentiation 1 (CD1) family of non-classical major histocompatibility complex class I molecules are known to present hydrophobic, primarily lipid antigens...
2018: Frontiers in Immunology
Francesca Giordano, Maximilian R Stammnitz, Elizabeth P Murchison, Zemin Ning
Motivation: The recent technological advances in genome sequencing techniques have resulted in an exponential increase in the number of sequenced human and non-human genomes. The ever increasing number of assemblies generated by novel de novo pipelines and strategies demands the development of new software to evaluate assembly quality and completeness. One way to determine the completeness of an assembly is by detecting its Presence-Absence variations (PAV) with respect to a reference, where PAVs between two assemblies are defined as the sequences present in one assembly but entirely missing in the other one...
March 28, 2018: Bioinformatics
Laura L W Cooling, Michelle Herrst, Sherri L Hugan
ABO-incompatible (ABOi) hematopoietic stem cell transplants (HSCTs) can present challenges in the blood bank. During transplantation, patients receive components that are ABO-compatible with both the donor graft and recipient; this practice can strain group O red blood cell (RBC) inventories.1 In addition, there are risks for acute hemolysis at the time of infusion and in the early post-transplant period.1,2 In ABO major-incompatible bone marrow HSCTs, which contain significant quantities of donor RBCs that are ABOi with recipient plasma, it is common to perform a RBC depletion of the bone marrow in an effort to minimize hemolysis at the time of infusion...
January 2018: Immunohematology
Kimberly Wong, Frempongma Wadee, Gali Ellenblum, Michael McCloskey
Knowledge of letter shapes is central to reading. In experiments focusing primarily on a single letter shape-the "looptail" lowercase print G -we found surprising gaps in skilled readers' knowledge. In Experiment 1 most participants failed to recall the existence of looptail g when asked if G has two lowercase print forms, and almost none were able to write looptail g accurately. In Experiment 2 participants searched for G s in text with multiple looptail g s. Asked immediately thereafter to write the g form they had seen, half the participants produced an "opentail" g (the typical handwritten form), and only one wrote looptail g accurately...
April 2, 2018: Journal of Experimental Psychology. Human Perception and Performance
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