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https://www.readbyqxmd.com/read/29339479/hif-signaling-in-osteoblast-lineage-cells-promotes-systemic-breast-cancer-growth-and-metastasis-in-mice
#1
Claire-Sophie Devignes, Yetki Aslan, Audrey Brenot, Audrey Devillers, Koen Schepers, Stéphanie Fabre, Jonathan Chou, Amy-Jo Casbon, Zena Werb, Sylvain Provot
Bone metastasis involves dynamic interplay between tumor cells and the local stromal environment. In bones, local hypoxia and activation of the hypoxia-inducible factor (HIF)-1α in osteoblasts are essential to maintain skeletal homeostasis. However, the role of osteoblast-specific HIF signaling in cancer metastasis is unknown. Here, we show that osteoprogenitor cells (OPCs) are located in hypoxic niches in the bone marrow and that activation of HIF signaling in these cells increases bone mass and favors breast cancer metastasis to bone locally...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29329516/bilateral-giant-retinal-tears-in-osteogenesis-imperfecta
#2
Paolo Scollo, Martin Paul Snead, Allan James Richards, Rebecca Pollitt, Catherine DeVile
BACKGROUND: Osteogenesis imperfecta (OI) is a rare primarily autosomal dominant condition in which the connective tissues of bones, ligaments and sclerae do not form properly. Typically, mutations in COL1A1 and COL1A2 genes lead to the defective formation or quantity of type I collagen, the principle matrix in these tissues. Molecular genetic studies have now elucidated multiple genetic subtypes of the disorder but little literature exists on the risk of retinal tears and detachments in OI...
January 12, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29322210/correction-to-dosimetry-in-clinical-radionuclide-therapy-the-devil-is-in-the-detail
#3
Francesco Giammarile, Kristoff Muylle, Roberto Delgado Bolton, Jolanta Kunikowska, Uwe Haberkorn, Wim Oyen
The above article which was published in Volume 44/ Issue 12 has incorrect page numbers. Instead of 1-3, it should have been 2137-2139.
January 11, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29313070/the-governance-of-indigenous-natural-products-in-namibia-a-policy-network-analysis
#4
Albertina Ndeinoma, K Freerk Wiersum, Bas Arts
At the end of the 20th century, optimism existed that non-timber forest products (NTFPs) can form an integral part in conservation and development strategies. However, there is limited knowledge on how the different stakeholders could relate to the state or to each other in promoting commercialization of NTFPs. Applying the policy network as an analytical framework, we investigated the structural patterns of actor relations in the governance structure of indigenous natural products (INPs) in Namibia, to understand the implications of such relations on INP policy process...
January 9, 2018: Environmental Management
https://www.readbyqxmd.com/read/29301772/cd19-car-t-therapy-and-sepsis-dancing-with-the-devil
#5
Lihua E Budde, John A Zaia
No abstract text is available yet for this article.
January 4, 2018: Blood
https://www.readbyqxmd.com/read/29299939/repurposing-drugs-for-use-against-zika-virus-infection
#6
J Devillers
Zika virus (ZIKV) is a mosquito-borne flavivirus for which there are no vaccines or specific therapeutics. To find drugs active on the virus is a complex, expensive and time-consuming process. The prospect of drug repurposing, which consists of finding new indications for existing drugs, is an interesting alternative to expedite drug development for specific diseases. In theory, drug repurposing is also able to respond much more rapidly to a crisis than a classical drug discovery process. Consequently, the methodology is attractive for vector-borne diseases that can emerge or re-emerge worldwide with the risk to become pandemic quickly...
January 4, 2018: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/29299641/responsibility-modulates-the-neural-correlates-of-regret-during-the-sequential-risk-taking-task
#7
Lin Li, Zhiyuan Liu, Huanghuang Niu, Li Zheng, Xuemei Cheng, Peng Sun, Fanzhi Anita Zhou, Xiuyan Guo
Responsibility is a necessary prerequisite in the experience of regret. The present fMRI study investigated the modulation of responsibility on the neural correlates of regret during a sequential risk-taking task. Participants were asked to open a series of boxes consecutively and decided when to stop. Each box contained a reward, except for one containing a devil to zero participant's gain in the trial. Once participants stopped, both collected gains and missed chances were revealed. We manipulated responsibility by setting two different contexts...
January 3, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29297829/occurrence-of-pasteurellaceae-bacteria-in-the-oral-cavity-of-selected-marsupial-species
#8
Mie Johanne Hansen, Mads F Bertelsen, Androo Kelly, Anders Miki Bojesen
Eighty-two Pasteurellaceae isolates from marsupials characterized by phylogenetic analysis of rpoB gene sequences formed five distinct groups. Twenty-one strains from long-nosed potoroos ( Potorous tridactylus apicalis), spotted-tailed quolls ( Dasyurus maculatus), and eastern quolls ( Dasyurus viverrinus) made up group 1, which classified with Frederiksenia canicola. Group 2, 15 strains from Tasmanian devils ( Sarcophilus harrisii), common wombats ( Vombatus ursinus), common ring-tailed possums ( Pseudocheirus peregrinus), and eastern quolls, grouped with Pasteurella multocida...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29297543/warfarin-better-the-devil-you-know
#9
EDITORIAL
Marc Blockman
No abstract text is available yet for this article.
November 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29282467/complete-revascularization-for-percutaneous-coronary-intervention-the-devil-is-in-the-details
#10
William S Weintraub
No abstract text is available yet for this article.
December 27, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29215911/weird-animals-sex-and-genome-evolution
#11
Jennifer A Marshall Graves
Making my career in Australia exposed me to the tyranny of distance, but it gave me opportunities to study our unique native fauna. Distantly related animal species present genetic variation that we can use to explore the most fundamental biological structures and processes. I have compared chromosomes and genomes of kangaroos and platypus, tiger snakes and emus, devils (Tasmanian) and dragons (lizards). I particularly love the challenges posed by sex chromosomes, which, apart from determining sex, provide stunning examples of epigenetic control and break all the evolutionary rules that we currently understand...
December 7, 2017: Annual Review of Animal Biosciences
https://www.readbyqxmd.com/read/29208849/possessions-including-poltergeist-are-you-there-madness
#12
Olivier Walusinski
Beliefs involving the devil and possession figured in the nosography of mental illness that alienists gradually established during the 19th century. The description of this form of cenesthetic hallucination resulted in "the possessed" being viewed as patients, which protected them from the trials and punishments they so frequently faced in earlier centuries. According to psychologists, this illusion of mental duality is linked to impairment of introspective capacities. Current brain imaging suggests inappropriate activity of the default mode network, which interferes with attentional systems during the hallucinatory episode...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29206499/expert-judgment-based-multicriteria-decision-models-to-assess-the-risk-of-pesticides-on-reproduction-failures-of-grey-partridge
#13
J Devillers, H Devillers, E Bro, F Millot
A suite of models is proposed for estimating the risk of pesticides against the grey partridge (Perdix perdix) and their clutches. Radio-tracked data of females, description and location of the clutches, and data on the pesticide treatments during the laying periods of the partridges were used as basic information. Quantitative structure-activity relationship (QSAR) and quantitative structure-property relationship (QSPR) modelling allowed us to characterize the pesticides by their 1-octanol/water partition coefficient (log P), vapour pressure, primary and ultimate biodegradation potential, acute toxicity (LD50) on P...
November 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/29201009/in-vitro-and-in-silico-risk-assessment-in-acquired-long-qt-syndrome-the-devil-is-in-the-details
#14
REVIEW
William Lee, Monique J Windley, Jamie I Vandenberg, Adam P Hill
Acquired long QT syndrome, mostly as a result of drug block of the Kv11. 1 potassium channel in the heart, is characterized by delayed cardiac myocyte repolarization, prolongation of the T interval on the ECG, syncope and sudden cardiac death due to the polymorphic ventricular arrhythmia Torsade de Pointes (TdP). In recent years, efforts are underway through the Comprehensive in vitro proarrhythmic assay (CiPA) initiative, to develop better tests for this drug induced arrhythmia based in part on in silico simulations of pharmacological disruption of repolarization...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29188006/radiation-of-the-polymorphic-little-devil-poison-frog-oophaga-sylvatica-in-ecuador
#15
Alexandre B Roland, Juan C Santos, Bella C Carriker, Stephanie N Caty, Elicio E Tapia, Luis A Coloma, Lauren A O'Connell
Some South American poison frogs (Dendrobatidae) are chemically defended and use bright aposematic colors to warn potential predators of their unpalatability. Aposematic signals are often frequency-dependent where individuals deviating from a local model are at a higher risk of predation. However, extreme diversity in the aposematic signal has been documented in poison frogs, especially in Oophaga. Here, we explore the phylogeographic pattern among color-divergent populations of the Little Devil poison frog Oophaga sylvatica by analyzing population structure and genetic differentiation to evaluate which processes could account for color diversity within and among populations...
November 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29183247/is-the-devil-in-the-detail-evidence-for-s-s-learning-after-unconditional-stimulus-revaluation-in-human-evaluative-conditioning-under-a-broader-set-of-experimental-conditions
#16
Hannah Jensen-Fielding, Camilla C Luck, Ottmar V Lipp
Whether valence change during evaluative conditioning is mediated by a link between the conditional stimulus (CS) and the unconditional stimulus (US; S-S learning) or between the CS and the unconditional response (S-R learning) is a matter of continued debate. Changing the valence of the US after conditioning, known as US revaluation, can be used to dissociate these accounts. Changes in CS valence after US revaluation provide evidence for S-S learning but if CS valence does not change, evidence for S-R learning is found...
November 28, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/29177364/hypertension-management-and-prevention-the-devil-is-ever-in-the-details
#17
EDITORIAL
Vernon Ms Oh
No abstract text is available yet for this article.
October 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29176811/dietary-partitioning-of-australia-s-two-marsupial-hypercarnivores-the-tasmanian-devil-and-the-spotted-tailed-quoll-across-their-shared-distributional-range
#18
Georgina E Andersen, Christopher N Johnson, Leon A Barmuta, Menna E Jones
Australia's native marsupial fauna has just two primarily flesh-eating 'hypercarnivores', the Tasmanian devil (Sarcophilus harrisii) and the spotted-tailed quoll (Dasyurus maculatus) which coexist only on the island of Tasmania. Devil populations are currently declining due to a fatal transmissible cancer. Our aim was to analyse the diet of both species across their range in Tasmania, as a basis for understanding how devil decline might affect the abundance and distribution of quolls through release from competition...
2017: PloS One
https://www.readbyqxmd.com/read/29162213/composition-of-marsupial-zona-pellucida-a-molecular-and-phylogenetic-approach
#19
Carla Moros-Nicolás, Pascale Chevret, María José Izquierdo-Rico, William V Holt, Daniela Esteban-Díaz, Manel López-Béjar, Eva Martínez-Nevado, Maria A Nilsson, José Ballesta, Manuel Avilés
The zona pellucida (ZP) is an extracellular matrix that surrounds mammalian oocytes. In eutherians it is formed from three or four proteins (ZP1, ZP2, ZP3, ZP4). In the few marsupials that have been studied, however, only three of these have been characterised (ZP2, ZP3, ZP4). Nevertheless, the composition in marsupials may be more complex, since a duplication of the ZP3 gene was recently described in one species. The aim of this work was to elucidate the ZP composition in marsupials and relate it to the evolution of the ZP gene family...
November 22, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29161957/induced-pluripotent-stem-cells-from-a-marsupial-the-tasmanian-devil-sarcophilus-harrisii-insight-into-the-evolution-of-mammalian-pluripotency
#20
Prasanna Weeratunga, Arash Shahsavari, Dmitry A Ovchinnikov, Ernst Jurgen Wolvetang, Deanne Jeanette Whitworth
We demonstrate the generation of Tasmanian devil (Sarcophilus harrisii) induced pluripotent stem cells (DeviPSCs) from dermal fibroblasts by lentiviral delivery of human transcription factors. DeviPSCs display characteristic pluripotent stem cell colony morphology, with individual cells having a high nuclear to cytoplasmic ratio and alkaline phosphatase activity. DeviPSCs are leukemia inhibitory factor-dependent and have reactivated endogenous OCT4 (POU5F1), POU2 (POU5F3), SOX2, NANOG and DAX1 genes, retained a normal karyotype, and concurrently silenced exogenous human transgenes...
November 22, 2017: Stem Cells and Development
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