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https://www.readbyqxmd.com/read/28646816/the-devil-and-the-details
#1
EDITORIAL
Robert G Keim
No abstract text is available yet for this article.
March 2017: Journal of Clinical Orthodontics: JCO
https://www.readbyqxmd.com/read/28626387/the-case-for-abandoning-therapeutic-chelation-of-copper-ions-in-alzheimer-s-disease
#2
REVIEW
Simon C Drew
The "therapeutic chelation" approach to treating Alzheimer's disease (AD) evolved from the metals hypothesis, with the premise that small molecules can be designed to prevent transition metal-induced amyloid deposition and oxidative stress within the AD brain. Over more than 20 years, countless in vitro studies have been devoted to characterizing metal binding, its effect on Aβ aggregation, ROS production, and in vitro toxicity. Despite a lack of evidence for any clinical benefit, the conjecture that therapeutic chelation is an effective approach for treating AD remains widespread...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28620577/population-structure-of-the-soft-tick-ornithodoros-maritimus-and-its-associated-infectious-agents-within-a-colony-of-its-seabird-host-larus-michahellis
#3
Marlene Dupraz, Céline Toty, Elodie Devillers, Thomas Blanchon, Eric Elguero, Marion Vittecoq, Sara Moutailler, Karen D McCoy
The epidemiology of vector-borne zoonoses depends on the movement of both hosts and vectors, which can differ greatly in intensity across spatial scales. Because of their life history traits and small size, vector dispersal may be frequent, but limited in distance. However, little information is available on vector movement patterns at local spatial scales, and particularly for ticks, transmitting the greatest diversity of recognized infectious agents. To test the degree to which ticks can disperse and disseminate pathogens at local scales, we investigated the temporal dynamics and population structure of the soft tick Ornithodoros maritimus within a colony of its seabird host, the Yellow-legged gull Larus michahellis...
August 2017: International Journal for Parasitology. Parasites and Wildlife
https://www.readbyqxmd.com/read/28618299/is-the-devil-in-the-detail-a-randomised-controlled-trial-of-guided-internet-based-cbt-for-perfectionism
#4
Roz Shafran, Tracey D Wade, Sarah J Egan, Radha Kothari, Hannah Allcott-Watson, Per Carlbring, Alexander Rozental, Gerhard Andersson
An internet guided self-help cognitive-behavioural treatment (ICBT) for perfectionism was recently found to be effective (see this issue). Such studies stand in need of replication. The aim of this study was to report the outcomes and predictors of change when the treatment is delivered in a UK setting. A total of 120 people (Mean = 28.9 years; 79% female) were randomised to receive ICBT or wait-list control over 12 weeks (trial registration: NCT02756871). While there were strong similarities between the current study and its Swedish counterpart, there were also important differences in procedural details...
May 26, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28614869/a-rosa-canina-urtica-dioica-harpagophytum-procumbens-zeyheri-combination-significantly-reduces-gonarthritis-symptoms-in-a-randomized-placebo-controlled-double-blind-study
#5
Margret Moré, Joerg Gruenwald, Ute Pohl, Ralf Uebelhack
The special formulation MA212 (Rosaxan) is composed of rosehip (Rosa canina L.) puree/juice concentrate, nettle (Urtica dioica L.) leaf extract, and devil's claw (Harpagophytum procumbens DC. ex Meisn. or Harpagophytum zeyheri Decne.) root extract and also supplies vitamin D. It is a food for special medical purposes ([EU] No 609/2013) for the dietary management of pain in patients with gonarthritis.This 12-week randomized, placebo-controlled double-blind parallel-design study aimed to investigate the efficacy and safety of MA212 versus placebo in patients with gonarthritis...
June 14, 2017: Planta Medica
https://www.readbyqxmd.com/read/28604113/qsar-models-for-predicting-the-toxicity-of-piperidine-derivatives-against-aedes-aegypti
#6
J P Doucet, E Papa, A Doucet-Panaye, J Devillers
QSAR models are proposed for predicting the toxicity of 33 piperidine derivatives against Aedes aegypti. From 2D topological descriptors, calculated with the PaDEL software, ordinary least squares multilinear regression (OLS-MLR) treatment from the QSARINS software and machine learning and related approaches including linear and radial support vector machine (SVM), projection pursuit regression (PPR), radial basis function neural network (RBFNN), general regression neural network (GRNN) and k-nearest neighbours (k-NN), led to four-variable models...
June 12, 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/28591214/-the-devil-has-entered-you-a-qualitative-study-of-men-who-have-sex-with-men-msm-and-the-stigma-and-discrimination-they-experience-from-healthcare-professionals-and-the-general-community-in-bosnia-and-herzegovina
#7
Stela Stojisavljevic, Bosiljka Djikanovic, Bojana Matejic
Men who have sex with men (MSM) are often exposed to unequal treatment in societies worldwide as well as to various forms of stigma and discrimination in healthcare services. Bosnia and Herzegovina (B&H) is a postconflict developing country located in Southeast Europe and the Western Balkans, where little is known about the experiences of MSM regarding their communities and interactions with healthcare services. The aim of this study was to explore the types of experiences MSM face and to assess the level of stigma and discrimination they are exposed to in this setting...
2017: PloS One
https://www.readbyqxmd.com/read/28591206/erbb3-a-potential-serum-biomarker-for-early-detection-and-therapeutic-target-for-devil-facial-tumour-1-dft1
#8
Dane A Hayes, Dale A Kunde, Robyn L Taylor, Stephen B Pyecroft, Sukhwinder Singh Sohal, Elizabeth T Snow
Devil Facial Tumour 1 (DFT1) is one of two transmissible neoplasms of Tasmanian devils (Sarcophilus harrisii) predominantly affecting their facial regions. DFT1's cellular origin is that of Schwann cell lineage where lesions are evident macroscopically late in the disease. Conversely, the pre-clinical timeframe from cellular transmission to appearance of DFT1 remains uncertain demonstrating the importance of an effective pre-clinical biomarker. We show that ERBB3, a marker expressed normally by the developing neural crest and Schwann cells, is immunohistohemically expressed by DFT1, therefore the potential of ERBB3 as a biomarker was explored...
2017: PloS One
https://www.readbyqxmd.com/read/28583402/between-the-devil-and-the-deep-blue-sea-use-of-real-time-tools-to-identify-children-with-severe-sepsis-in-the-pediatric-emergency-department
#9
EDITORIAL
Andrea T Cruz
No abstract text is available yet for this article.
May 27, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28574996/conversing-with-a-devil-s-advocate-interpersonal-coordination-in-deception-and-disagreement
#10
Nicholas D Duran, Riccardo Fusaroli
This study investigates the presence of dynamical patterns of interpersonal coordination in extended deceptive conversations across multimodal channels of behavior. Using a novel "devil's advocate" paradigm, we experimentally elicited deception and truth across topics in which conversational partners either agreed or disagreed, and where one partner was surreptitiously asked to argue an opinion opposite of what he or she really believed. We focus on interpersonal coordination as an emergent behavioral signal that captures interdependencies between conversational partners, both as the coupling of head movements over the span of milliseconds, measured via a windowed lagged cross correlation (WLCC) technique, and more global temporal dependencies across speech rate, using cross recurrence quantification analysis (CRQA)...
2017: PloS One
https://www.readbyqxmd.com/read/28532572/rates-and-causes-of-accidents-for-general-aviation-aircraft-operating-in-a-mountainous-and-high-elevation-terrain-environment
#11
Marisa Aguiar, Alan Stolzer, Douglas D Boyd
BACKGROUND: Flying over mountainous and/or high elevation terrain is challenging due to rapidly changeable visibility, gusty/rotor winds and downdrafts and the necessity of terrain avoidance. Herein, general aviation accident rates and mishap cause/factors were determined (2001-2014) for a geographical region characterized by such terrain. METHODS: Accidents in single piston engine-powered aircraft for states west of the US continental divide characterized by mountainous terrain and/or high elevation (MEHET) were identified from the NTSB database...
May 19, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28529303/social-perception-of-infertility-and-its-treatment-in-late-medieval-italy-margherita-datini-an-italian-merchant-s-wife
#12
Jong Kuk Nam
Because the perception of infertility in medieval Europe ranged from the extremely religious view of it as a malediction of God or the devil's work, to the reasonable medical conception of it as a sort of disease to treat, it is very difficult to determine the general attitudes of ordinary people towards infertility. This article seeks to elucidate the common social perception of infertility and its treatment in late medieval Europe by analyzing the case of Margherita Datini, an Italian merchant's wife who lived in the 1400s...
December 2016: Ŭi Sahak
https://www.readbyqxmd.com/read/28526824/increasing-generations-in-captivity-is-associated-with-increased-vulnerability-of-tasmanian-devils-to-vehicle-strike-following-release-to-the-wild
#13
Catherine E Grueber, Elizabeth E Reid-Wainscoat, Samantha Fox, Katherine Belov, Debra M Shier, Carolyn J Hogg, David Pemberton
Captive breeding of threatened species, for release to the wild, is critical for conservation. This strategy, however, risks producing captive-raised animals with traits poorly suited to the wild. We describe the first study to characterise accumulated consequences of long-term captive breeding on behaviour, by following the release of Tasmanian devils to the wild. We test the impact of prolonged captive breeding on the probability that captive-raised animals are fatally struck by vehicles. Multiple generations of captive breeding increased the probability that individuals were fatally struck, a pattern that could not be explained by other confounding factors (e...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28518201/a-general-diastereoselective-synthesis-of-highly-functionalized-ferrocenyl-ambiphiles-enabled-on-a-large-scale-by-electrochemical-purification
#14
Emmanuel Lerayer, Patrice Renaut, Julien Roger, Nadine Pirio, Hélène Cattey, Charles H Devillers, Dominique Lucas, Jean-Cyrille Hierso
A general synthesis of highly functionalized ferrocenes, which include (P,B)- and (N,B)-ambiphiles, has been developed at a multigram scale. Diastereoselective stepwise modification of di-tert-butylated ferrocenes included the unprecedented separation of electroactive species. Bulky alkyl groups on ferrocenes ensure planar chirality of ambiphiles and enforce closer proximity of antagonist Lewis functions.
May 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28516231/molecular-evolution-of-type-ii-mage-genes-from-ancestral-maged2-gene-and-their-phylogenetic-resolution-of-basal-mammalian-clades
#15
Marcos De Donato, Sunday O Peters, Tanveer Hussain, Hectorina Rodulfo, Bolaji N Thomas, Masroor E Babar, Ikhide G Imumorin
Type II melanoma-associated antigens (MAGE) are a subgroup of about a dozen proteins found in various locations in the genome and expressed in normal tissues, thus are not related to cancer as the type I MAGE genes. This gene family exists as a single copy in non-mammals and monotremata, but found as two copies in metatherians and occur as a diverse group in all eutherians. Our studies suggest MAGED2 as the ancestor of this subfamily and the most likely evolutionary history of eutherian type II MAGE genes is hereby proposed based on synteny conservation, phylogenetic relations, genome location, homology conservation, and the protein and gene structures...
May 17, 2017: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/28515726/comparative-analysis-of-immune-checkpoint-molecules-and-their-potential-role-in-the-transmissible-tasmanian-devil-facial-tumor-disease
#16
Andrew S Flies, Nicholas B Blackburn, Alan Bruce Lyons, John D Hayball, Gregory M Woods
Immune checkpoint molecules function as a system of checks and balances that enhance or inhibit immune responses to infectious agents, foreign tissues, and cancerous cells. Immunotherapies that target immune checkpoint molecules, particularly the inhibitory molecules programmed cell death 1 and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), have revolutionized human oncology in recent years, yet little is known about these key immune signaling molecules in species other than primates and rodents. The Tasmanian devil facial tumor disease is caused by transmissible cancers that have resulted in a massive decline in the wild Tasmanian devil population...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28511937/hot-start-to-european-pluripotent-stem-cell-banking
#17
Paul A De Sousa, Rachel Steeg, Beate Kreisel, Timothy E Allsopp
Achieving consistency in standards of access to and quality of human induced pluripotent stem cells has lagged behind their use. In Europe, a network of academic and industrial partners has been established to overcome this challenge. The experience reveals the devil in the detail of worthy ambitions informing future efforts.
July 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28511762/a-conversation-with-henry-dephilips-md-the-doctor-in-the-teladoc-house
#18
Peter Wehrwein
The CMO of Teladoc, one of the country's largest telemedicine providers, certainly knows how to sing the praises of the industry, and handle devil's advocate kind of questions as well. Most of Teledoc's customers are commercial insurers and employers. Medicare? Not so much. Medicaid makes "perfect sense."
April 2017: Managed Care
https://www.readbyqxmd.com/read/28505813/devil-s-staircase-continuum-in-the-chiral-clock-spin-glass-with-competing-ferromagnetic-antiferromagnetic-and-left-right-chiral-interactions
#19
Tolga Çağlar, A Nihat Berker
The chiral clock spin-glass model with q=5 states, with both competing ferromagnetic-antiferromagnetic and left-right chiral frustrations, is studied in d=3 spatial dimensions by renormalization-group theory. The global phase diagram is calculated in temperature, antiferromagnetic bond concentration p, random chirality strength, and right-chirality concentration c. The system has a ferromagnetic phase, a multitude of different chiral phases, a chiral spin-glass phase, and a critical (algebraically) ordered phase...
April 2017: Physical Review. E
https://www.readbyqxmd.com/read/28501298/ace2-as-therapy-for-glomerular-disease-the-devil-is-in-the-detail
#20
Michael J Ross, Masaomi Nangaku
Angiotensin-converting enzyme 2 cleaves angiotensin (Ang) II to Ang(1-7), which antagonizes the deleterious effects of Ang II. In this issue, 2 groups administered angiotensin-converting enzyme 2 in murine models of kidney disease. Angiotensin-converting enzyme 2 did not improve glomerular injury in 2 models of mild diabetic nephropathy but was partially protective in an Alport syndrome model. These discrepant findings may be explained by the inability of angiotensin-converting enzyme 2 to reach the urinary space in the absence of severe proteinuria...
June 2017: Kidney International
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