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https://www.readbyqxmd.com/read/28532572/rates-and-causes-of-accidents-for-general-aviation-aircraft-operating-in-a-mountainous-and-high-elevation-terrain-environment
#1
Marisa Aguiar, Alan Stolzer, Douglas D Boyd
BACKGROUND: Flying over mountainous and/or high elevation terrain is challenging due to rapidly changeable visibility, gusty/rotor winds and downdrafts and the necessity of terrain avoidance. Herein, general aviation accident rates and mishap cause/factors were determined (2001-2014) for a geographical region characterized by such terrain. METHODS: Accidents in single piston engine-powered aircraft for states west of the US continental divide characterized by mountainous terrain and/or high elevation (MEHET) were identified from the NTSB database...
May 19, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28529303/social-perception-of-infertility-and-its-treatment-in-late-medieval-italy-margherita-datini-an-italian-merchant-s-wife
#2
Jong Kuk Nam
Because the perception of infertility in medieval Europe ranged from the extremely religious view of it as a malediction of God or the devil's work, to the reasonable medical conception of it as a sort of disease to treat, it is very difficult to determine the general attitudes of ordinary people towards infertility. This article seeks to elucidate the common social perception of infertility and its treatment in late medieval Europe by analyzing the case of Margherita Datini, an Italian merchant's wife who lived in the 1400s...
December 2016: Ŭi Sahak
https://www.readbyqxmd.com/read/28526824/increasing-generations-in-captivity-is-associated-with-increased-vulnerability-of-tasmanian-devils-to-vehicle-strike-following-release-to-the-wild
#3
Catherine E Grueber, Elizabeth E Reid-Wainscoat, Samantha Fox, Katherine Belov, Debra M Shier, Carolyn J Hogg, David Pemberton
Captive breeding of threatened species, for release to the wild, is critical for conservation. This strategy, however, risks producing captive-raised animals with traits poorly suited to the wild. We describe the first study to characterise accumulated consequences of long-term captive breeding on behaviour, by following the release of Tasmanian devils to the wild. We test the impact of prolonged captive breeding on the probability that captive-raised animals are fatally struck by vehicles. Multiple generations of captive breeding increased the probability that individuals were fatally struck, a pattern that could not be explained by other confounding factors (e...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28518201/a-general-diastereoselective-synthesis-of-highly-functionalized-ferrocenyl-ambiphiles-enabled-on-a-large-scale-by-electrochemical-purification
#4
Emmanuel Lerayer, Patrice Renaut, Julien Roger, Nadine Pirio, Hélène Cattey, Charles H Devillers, Dominique Lucas, Jean-Cyrille Hierso
A general synthesis of highly functionalized ferrocenes, which include (P,B)- and (N,B)-ambiphiles, has been developed at a multigram scale. Diastereoselective stepwise modification of di-tert-butylated ferrocenes included the unprecedented separation of electroactive species. Bulky alkyl groups on ferrocenes ensure planar chirality of ambiphiles and enforce closer proximity of antagonist Lewis functions.
May 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28516231/molecular-evolution-of-type-ii-mage-genes-from-ancestral-maged2-gene-and-their-phylogenetic-resolution-of-basal-mammalian-clades
#5
Marcos De Donato, Sunday O Peters, Tanveer Hussain, Hectorina Rodulfo, Bolaji N Thomas, Masroor E Babar, Ikhide G Imumorin
Type II melanoma-associated antigens (MAGE) are a subgroup of about a dozen proteins found in various locations in the genome and expressed in normal tissues, thus are not related to cancer as the type I MAGE genes. This gene family exists as a single copy in non-mammals and monotremata, but found as two copies in metatherians and occur as a diverse group in all eutherians. Our studies suggest MAGED2 as the ancestor of this subfamily and the most likely evolutionary history of eutherian type II MAGE genes is hereby proposed based on synteny conservation, phylogenetic relations, genome location, homology conservation, and the protein and gene structures...
May 17, 2017: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/28515726/comparative-analysis-of-immune-checkpoint-molecules-and-their-potential-role-in-the-transmissible-tasmanian-devil-facial-tumor-disease
#6
Andrew S Flies, Nicholas B Blackburn, Alan Bruce Lyons, John D Hayball, Gregory M Woods
Immune checkpoint molecules function as a system of checks and balances that enhance or inhibit immune responses to infectious agents, foreign tissues, and cancerous cells. Immunotherapies that target immune checkpoint molecules, particularly the inhibitory molecules programmed cell death 1 and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), have revolutionized human oncology in recent years, yet little is known about these key immune signaling molecules in species other than primates and rodents. The Tasmanian devil facial tumor disease is caused by transmissible cancers that have resulted in a massive decline in the wild Tasmanian devil population...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28511937/hot-start-to-european-pluripotent-stem-cell-banking
#7
Paul A De Sousa, Rachel Steeg, Beate Kreisel, Timothy E Allsopp
Achieving consistency in standards of access to and quality of human induced pluripotent stem cells has lagged behind their use. In Europe, a network of academic and industrial partners has been established to overcome this challenge. The experience reveals the devil in the detail of worthy ambitions informing future efforts.
May 13, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28511762/a-conversation-with-henry-dephilips-md-the-doctor-in-the-teladoc-house
#8
Peter Wehrwein
The CMO of Teladoc, one of the country's largest telemedicine providers, certainly knows how to sing the praises of the industry, and handle devil's advocate kind of questions as well. Most of Teledoc's customers are commercial insurers and employers. Medicare? Not so much. Medicaid makes "perfect sense."
April 2017: Managed Care
https://www.readbyqxmd.com/read/28505813/devil-s-staircase-continuum-in-the-chiral-clock-spin-glass-with-competing-ferromagnetic-antiferromagnetic-and-left-right-chiral-interactions
#9
Tolga Çağlar, A Nihat Berker
The chiral clock spin-glass model with q=5 states, with both competing ferromagnetic-antiferromagnetic and left-right chiral frustrations, is studied in d=3 spatial dimensions by renormalization-group theory. The global phase diagram is calculated in temperature, antiferromagnetic bond concentration p, random chirality strength, and right-chirality concentration c. The system has a ferromagnetic phase, a multitude of different chiral phases, a chiral spin-glass phase, and a critical (algebraically) ordered phase...
April 2017: Physical Review. E
https://www.readbyqxmd.com/read/28501298/ace2-as-therapy-for-glomerular-disease-the-devil-is-in-the-detail
#10
Michael J Ross, Masaomi Nangaku
Angiotensin-converting enzyme 2 cleaves angiotensin (Ang) II to Ang(1-7), which antagonizes the deleterious effects of Ang II. In this issue, 2 groups administered angiotensin-converting enzyme 2 in murine models of kidney disease. Angiotensin-converting enzyme 2 did not improve glomerular injury in 2 models of mild diabetic nephropathy but was partially protective in an Alport syndrome model. These discrepant findings may be explained by the inability of angiotensin-converting enzyme 2 to reach the urinary space in the absence of severe proteinuria...
June 2017: Kidney International
https://www.readbyqxmd.com/read/28500945/carbohydrate-based-electrochemical-biosensor-for-detection-of-a-cancer-biomarker-in-human-plasma
#11
Marion Devillers, Lama Ahmad, Hafsa Korri-Youssoufi, Laurent Salmon
Autocrine motility factor (AMF) is a tumor-secreted cytokine that stimulates tumor cell motility in vitro and metastasis in vivo. AMF could be detected in serum or urine of cancer patients with worse prognosis. Reported as a cancer biomarker, AMF secretion into body fluids might be closely related to metastases formation. In this study, a sensitive and specific carbohydrate-based electrochemical biosensor was designed for the detection and quantification of a protein model of AMF, namely phosphoglucose isomerase from rabbit muscle (RmPGI)...
April 23, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28500329/no-evidence-of-inbreeding-depression-in-a-tasmanian-devil-insurance-population-despite-significant-variation-in-inbreeding
#12
Rebecca Gooley, Carolyn J Hogg, Katherine Belov, Catherine E Grueber
Inbreeding depression occurs when inbred individuals experience reduced fitness as a result of reduced genome-wide heterozygosity. The Tasmanian devil faces extinction due to a contagious cancer, devil facial tumour disease (DFTD). An insurance metapopulation was established in 2006 to ensure the survival of the species and to be used as a source population for re-wilding and genetic rescue. The emergence of DFTD and the rapid decline of wild devil populations have rendered the species at risk of inbreeding depression...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28498593/involvement-in-decision-making-the-devil-is-in-the-detail
#13
Rose McCabe
No abstract text is available yet for this article.
June 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/28485627/reply-to-the-timing-of-early-antibiotics-and-hospital-mortality-in-sepsis-playing-devil-s-advocate
#14
Vincent Liu, Vikram Fielding-Singh, Theodore J Iwashyna, Jay Bhattacharya, Gabriel Escobar
No abstract text is available yet for this article.
May 9, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28485616/the-timing-of-early-antibiotics-and-hospital-mortality-in-sepsis-playing-devil-s-advocate
#15
Jason Chertoff, Ali Ataya
No abstract text is available yet for this article.
May 9, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28484632/relict-or-reintroduction-genetic-population-assignment-of-three-tasmanian-devils-sarcophilus-harrisii-recovered-on-mainland-australia
#16
Lauren C White, Jeremy J Austin
Today, the Tasmanian devil (Sarcophilus harrisii) is found only on the island of Tasmania, despite once being widespread across mainland Australia. While the devil is thought to have become extinct on the mainland approximately 3000 years ago, three specimens were collected in Victoria (south-eastern Australia) between 1912 and 1991, raising the possibility that a relict mainland population survived in the area. Alternatively, these devils may have escaped captivity or were deliberately released after being transported from Tasmania, a practice that has been strictly controlled since the onset of devil facial tumour disease in the early 1990s...
April 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28471291/thomas-mann-s-depiction-of-neurosyphilis-and-other-diseases
#17
François Boller, Nicoletta Caputi
Thomas Mann (1875-1955), a Nobel Prize recipient rightly considered one of the great novelists of the twentieth century, was one of the most medically perceptive writers of recent times. His novels take place against the background of the different plagues (tuberculosis, cholera) that characterized the eighteenth and nineteenth centuries. One of Mann's later novels, Doctor Faustus, is set against a background of syphilis. In the 500-page book, which is subtitled The Life of the German Composer Adrian Leverkühn as told by a Friend, we see the theologian turned composer make a pact with the devil...
May 4, 2017: Journal of the History of the Neurosciences
https://www.readbyqxmd.com/read/28460677/seasonality-and-breeding-success-of-captive-and-wild-tasmanian-devils-sarcophilus-harrisii
#18
T Keeley, T Russell, K Carmody, G Kirk, T Eastley, A Britt-Lewis, M Post, M Burridge, S Eccleston, T Faulkner, T Forge, J Leonard, R L Hughes
The synchrony and timing of reproductive events are crucially important factors to maximize individual and offspring survival, especially in seasonal environments. To increase our understanding of the physiological basis of seasonality and the influence of associated environmental factors (maximum temperature, day length and rate of day length change associated with different latitudes) on reproduction in Tasmanian devils, we reviewed records and research data from captive facilities throughout Australia in comparison to those from a wild population study (1974-1987)...
June 2017: Theriogenology
https://www.readbyqxmd.com/read/28445080/bridging-the-data-sharing-divide-seeing-the-devil-in-the-details-not-the-other-camp
#19
Lisa Rosenbaum
No abstract text is available yet for this article.
April 26, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28442814/syphilis-incognito-resurgence-of-the-covert-devil-keeping-the-eyes-open
#20
Ankita Srivastava
No abstract text is available yet for this article.
January 2017: Indian Journal of Sexually Transmitted Diseases
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