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https://www.readbyqxmd.com/read/28086903/negative-immune-factors-might-predominate-local-tumor-immune-status-and-promote-carcinogenesis-in-cervical-carcinoma
#1
Minyi Zhao, Yang Li, Xing Wei, Qian Zhang, Hongran Jia, Shimin Quan, Di Cao, Li Wang, Ting Yang, Juan Zhao, Meili Pei, Sijuan Tian, Yang Yu, Yanping Guo, Xiaofeng Yang
BACKGROUND: The disequilibrium of local immune microenvironment is an essential element during tumorigenesis. METHOD: By conducting real-time polymerase chain reaction, we identified the mRNA level of immune factors, FoxP3 (forkhead box protein P3), CCL22/CCR4 (chemokine (C-C motif) ligand 22/CC chemokine receptor 4), OX40L/OX40 (tumor necrosis factor superfamily member 4/tumor necrosis factor receptor superfamily member 4) and Smad3 (SMAD family member 3) in neoplastic foci and its periphery tissues from 30 cases of squamous cervical carcinoma and 20 cases of normal cervix...
January 13, 2017: Virology Journal
https://www.readbyqxmd.com/read/28086795/atherosclerotic-and-thrombotic-genetic-and-environmental-determinants-in-egyptian-coronary-artery-disease-patients-a-pilot-study
#2
Manal S Fawzy, Eman A Toraih, Nagwa M Aly, Abeer Fakhr-Eldeen, Dahlia I Badran, Mohammad H Hussein
BACKGROUND: Coronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide. Multiple genetic variants in combination with various environmental risk factors have been implicated. This study aimed to investigate the association of twelve thrombotic and atherosclerotic gene variants in combination with other environmental risk factors with CAD risk in a preliminary sample of Egyptian CAD patients. METHODS: Twenty three consecutive CAD patients undergoing diagnostic coronary angiography and 34 unrelated controls, have been enrolled in the study...
January 13, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28081196/how-social-ties-influence-consumer-evidence-from-event-related-potentials
#3
Jing Luan, Zhong Yao, Yan Bai
A considerable amount of marketing research has reported that consumers are more saliently influenced by friends (strong social ties) than by acquaintances and strangers (weak social ties). To shed light on the neural and psychological processes underlying such phenomenon, in this study we designed an amended S1-S2 paradigm (product-[reviewer-review]) that is based on realistic consumer purchase experiences. After incoming all given information (product, reviewer, review), participants were required to state their purchase intentions...
2017: PloS One
https://www.readbyqxmd.com/read/28077821/ascending-aortic-constriction-promotes-cardiomyocyte-proliferation-in-neonatal-rats
#4
Zhenhua Wang, Sebastian Schmull, Hui Zheng, Jianggui Shan, Rongjiang Zou, Song Xue
Adult heart suffering from increased workload will undergo myocardial hypertrophy, subsequent cardiomyocyte (CM) death, and eventually heart failure. However, the effect of increasing afterload on the neonatal heart remains unknown. We performed ascending aortic constriction (AAC) in neonatal rats 8-12 hours after birth (P0, P indicates postpartum). Seven days after surgery, in vivo heart function was evaluated using cardiac ultrasonography. Haematoxylineosin and Masson staining were used to assess CM diameter and collagen deposition...
January 11, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28069381/establishment-of-a-mutation-system-in-tetrahymena-outer-arm-dynein-and-p-loop-functions-of-the-alpha-heavy-chain-dyh3p
#5
Masaki Edamatsu
Axonemal dyneins are large AAA+ type motor proteins that exhibit unique motor properties during ciliary beating. This study established a mutation system for Tetrahymena outer arm dynein and characterized four nucleotide-binding loops (P-loops; P1-P4) in the alpha heavy chain (Dyh3p). Macronuclear transformation of the mutant DYH3 genes in DYH3-knockout (KO-DYH3) cells enabled P-loop mutations that abolish the ability of nucleotide binding to be stably maintained in the polyploid genome. This mutation system revealed that the P3 and P4 mutant dyneins rescued lethality in macronuclear KO-DYH3 cells and exhibited normal ciliary localization...
January 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28068353/speech-timing-deficit-of-stuttering-evidence-from-contingent-negative-variations
#6
Ning Ning, Danling Peng, Xiangping Liu, Shuang Yang
The aim of the present study was to investigate the speech preparation processes of adults who stutter (AWS). Fifteen AWS and fifteen adults with fluent speech (AFS) participated in the experiment. The event-related potentials (ERPs) were recorded in a foreperiod paradigm. The warning signal (S1) was a color square, and the following imperative stimulus (S2) was either a white square (the Go signal that required participants to name the color of S1) or a white dot (the NoGo signal that prevents participants from speaking)...
2017: PloS One
https://www.readbyqxmd.com/read/28059473/striosomal-dysfunction-affects-behavioral-adaptation-but-not-impulsivity-evidence-from-x-linked-dystonia-parkinsonism
#7
Christian Beste, Moritz Mückschel, Raymond Rosales, Aloysius Domingo, Lillian Lee, Arlene Ng, Christine Klein, Alexander Münchau
BACKGROUND: Executive functions including behavioral adaptation and impulse control are commonly impaired in movement disorders caused by striatal pathology. However, as yet it is unclear what aspects of behavioral abnormalities are related to pathology in which striatal subcomponent, that is, the matrix and the striosomes. We therefore studied cognitive control in X-linked dystonia-parkinsonism, a model disease of striosomal degeneration, using behavioral paradigms and EEG. METHODS: We studied genetically confirmed X-linked dystonia-parkinsonism patients (N = 21) in their early disease stages and healthy matched controls...
January 6, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28057925/decreased-empathy-response-to-other-people-s-pain-in-bipolar-disorder-evidence-from-an-event-related-potential-study
#8
Jingyue Yang, Xinglong Hu, Xiaosi Li, Lei Zhang, Yi Dong, Xiang Li, Chunyan Zhu, Wen Xie, Jingjing Mu, Su Yuan, Jie Chen, Fangfang Chen, Fengqiong Yu, Kai Wang
Bipolar disorder (BD) patients often demonstrate poor socialization that may stem from a lower capacity for empathy. We examined the associated neurophysiological abnormalities by comparing event-related potentials (ERP) between 30 BD patients in different states and 23 healthy controls (HCs, matched for age, sex, and education) during a pain empathy task. Subjects were presented pictures depicting pain or neutral images and asked to judge whether the person shown felt pain (pain task) and to identify the affected side (laterality task) during ERP recording...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28053670/the-complete-genome-sequence-of-cronobacter-sakazakii-atcc-29544-t-a-food-borne-pathogen-isolated-from-a-child-s-throat
#9
Seongok Kim, You-Tae Kim, Hyunjin Yoon, Ju-Hoon Lee, Sangryeol Ryu
BACKGROUND: Cronobacter sakazakii is an emerging opportunistic pathogen that is associated with rare but life-threatening cases of severe diseases: meningitis, necrotizing enterocolitis, and sepsis in premature and full-term infants. However, the pathogenesis mechanism of this pathogen remains largely unknown. To determine its pathogenesis at the genomic level, the genome of C. sakazakii ATCC 29544(T) was completely sequenced and analyzed. RESULTS: The genomic DNA, containing a circular chromosome and three plasmids, is composed of 4,511,265 bp with a GC content of 56...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28052712/the-effects-of-perinatal-steroid-therapy-on-growth-factor-levels-during-different-stages-of-the-developing-brain
#10
Burçin İşcan, Funda Tuzun, Serap Cilaker Micili, Kazim Tugyan, Nuray Duman, Hasan Ozkan, Abdullah Kumral
OBJECTIVE: Excess glucocorticoid exposure on the fetal brain during critical stages of development has considerable effects on the development of the central nervous system. This study thus aimed to evaluate the differential effects of glucocorticoid exposure on critical growth factor levels during different stages of brain maturation. METHODS: For this purpose, forty-two rat pups were divided into six groups based on the timing of betamethasone administration. Rats in the treatment groups were exposed to intraperitoneal betamethasone injections beginning at different time points (postnatal days 1, 2, and 3)...
January 4, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28049590/inhibitory-potential-of-flavonoids-on-ptdins-3-4-5-p3-binding-with-the-phosphoinositide-dependent-kinase-1-pleckstrin-homology-domain
#11
Yelin Kang, Bong-Gyu Kim, Sunghoon Kim, Youngshim Lee, Youngdae Yoon
Many membrane-associated proteins are involved in various signaling pathways, including the phosphoinositide 3-kinase (PI3K) pathway, which has key roles in diverse cellular processes. Disruption of the activities of these proteins is involved in the development of disease in humans, making these proteins promising targets for drug development. In most cases, the catalytic domain is targeted; however, it is also possible to target membrane associations in order to regulate protein activity. In this study, we established a novel method to study protein-lipid interactions and screened for flavonoid-derived antagonists of PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 (PDK1) pleckstrin homology (PH) domain...
December 23, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28043368/chicken-egg-yolk-plasma-in-tris-citric-acid-extender-improves-the-quality-and-fertility-of-cryopreserved-water-buffalo-bubalus-bubalis-spermatozoa
#12
S Aftab Hussain Shah, S Murtaza Hassan Andrabi, Hussain Ahmed, Irfan Zia Qureshi
This study was primarily designed to evaluate the effect of different concentrations of ultraviolet (UV)-C-irradiated chicken egg yolk plasma (EYP; v:v; 10%, P1; 15%, P2; 20%, P3) or 20% (v:v) of whole chicken egg yolk (WCEY) in tris-citric acid (TCA) extender on water buffalo sperm quality during cryopreservation (postdilution, PD; postequilibration, PE; post-thawing, PT). Also the effect of best evolved concentration of UV-C-irradiated EYP in extender on in vivo fertility of buffalo spermatozoa was evaluated...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/28040266/angiotensin-ii-at1-receptor-signaling-is-necessary-for-cyclooxygenase-2-dependent-postnatal-nephron-generation
#13
Stefanie Frölich, Patrick Slattery, Dominique Thomas, Itamar Goren, Nerea Ferreiros, Boye L Jensen, Rolf M Nüsing
Deletion of cyclooxygenase-2 (COX-2) causes impairment of postnatal kidney development. Here we tested whether the renin angiotensin system contributes to COX-2-dependent nephrogenesis in mice after birth and whether a rescue of impaired renal development and function in COX-2(-/-) mice was achievable. Plasma renin concentration in mouse pups showed a birth peak and a second peak around day P8 during the first 10 days post birth. Administration of the angiotensin II receptor AT1 antagonist telmisartan from day P1 to P3 did not result in cortical damage...
December 28, 2016: Kidney International
https://www.readbyqxmd.com/read/28040012/enhanced-auditory-spatial-performance-using-individualized-head-related-transfer-functions-an-event-related-potential-study
#14
Matthew G Wisniewski, Griffin D Romigh, Stephanie M Kenzig, Nandini Iyer, Brian D Simpson, Eric R Thompson, Clayton D Rothwell
This study examined event-related potential (ERP) correlates of auditory spatial benefits gained from rendering sounds with individualized head-related transfer functions (HRTFs). Noise bursts with identical virtual elevations (0°-90°) were presented back-to-back in 5-10 burst "runs" in a roving oddball paradigm. Detection of a run's start (i.e., elevation change detection) was enhanced when bursts were rendered with an individualized compared to a non-individualized HRTF. ERPs showed increased P3 amplitudes to first bursts of a run in the individualized HRTF condition...
December 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28039922/the-p3-cognitive-erp-has-at-least-some-sensory-modality-specific-generators-evidence-from-high-resolution-eeg
#15
Jurij Dreo, Daniel Attia, Zvezdan Pirtošek, Grega Repovš
The P3 can arguably be named the most intensely studied ERP. In spite of more than 40 years of research, fundamental questions regarding the nature of its neural generators remain unresolved. While most studies conclude that the P3 is a true classical "endogenous" potential, and that its surface potential distribution remains constant across sensory modalities, these results are largely based on low-density EEG recordings, without the use of high-resolution methods such as the spherical spline Laplacian (SSL)...
December 31, 2016: Psychophysiology
https://www.readbyqxmd.com/read/28034803/computational-eeg-modelling-of-decision-making-under-ambiguity-reveals-spatio-temporal-dynamics-of-outcome-evaluation
#16
Lee Jollans, Robert Whelan, Louise Venables, Oliver H Turnbull, Matteo Cella, Simon Dymond
Complex human cognition, such as decision-making under ambiguity, is reflected in dynamic spatio-temporal activity in the brain. Here, we combined event-related potentials with computational modelling of the time course of decision-making and outcome evaluation during the Iowa Gambling Task. Measures of choice probability generated using the Prospect Valence Learning Delta (PVL-Delta) model, in addition to objective trial outcomes (outcome magnitude and valence), were applied as regressors in a general linear model of the EEG signal...
December 26, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/28032678/nacnac-cobalt-mediated-p4-transformations
#17
Manfred Scheer, Fabian Spitzer, Christian Graßl, Gabor Balazs, Eric Mädl, Eva Zolnhofer, Martin Keilwerth, Karsten Meyer
A comparison of P4 activations mediated by low-valent β diketiminato (L) cobalt complexes is presented. The formal Co(0) source [K2(L3Co)2(µ2:ƞ1,ƞ1-N2)] (1) reacts with P4 to form a mixture of the monoanionic complexes [K(thf)6][(L3Co)2(µ2:ƞ4,ƞ4-P4)] (2) and [K(thf)6][(L3Co)2(µ2:ƞ3,ƞ3-P3)] (3). The analogue Co(I) precursor [L3Co(tol)] (4a), however, selectively yields the corresponding neutral derivative [(L3Co)2(µ2:ƞ4,ƞ4-P4)] (5a). Compound 5a undergoes thermal P atom loss to form the unprecedented complex [(L3Co)2(µ2:ƞ3,ƞ3-P3)] (6)...
December 29, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28031198/a-phage-like-incy-plasmid-carrying-the-mcr-1-gene-in-escherichia-coli-from-a-pig-farm-in-china
#18
Chunping Zhang, Yuqing Feng, Fei Liu, Hui Jiang, Zhina Qu, Meng Lei, Jianfeng Wang, Bing Zhang, Yongfei Hu, Jiabo Ding, Baoli Zhu
We report here a new type of plasmid that carries the mcr-1 gene, the pMCR-1-P3 plasmid, harbored in an Escherichia coli strain isolated from a pig farm in China. pMCR-1-P3 belongs to the IncY incompatibility group, and is a phage-like plasmid that contains a large portion of phage-related sequences. The backbone of this plasmid is different from other mcr-1-carrying plasmids reported previously.
December 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28026876/variability-of-ica-decomposition-may-impact-eeg-signals-when-used-to-remove-eyeblink-artifacts
#19
Matthew B Pontifex, Kathryn L Gwizdala, Andrew C Parks, Martin Billinger, Clemens Brunner
Despite the growing use of independent component analysis (ICA) algorithms for isolating and removing eyeblink-related activity from EEG data, we have limited understanding of how variability associated with ICA uncertainty may be influencing the reconstructed EEG signal after removing the eyeblink artifact components. To characterize the magnitude of this ICA uncertainty and to understand the extent to which it may influence findings within ERP and EEG investigations, ICA decompositions of EEG data from 32 college-aged young adults were repeated 30 times for three popular ICA algorithms...
December 27, 2016: Psychophysiology
https://www.readbyqxmd.com/read/28026196/unresolved-loss-a-risk-factor-for-offspring-predicts-event-related-potential-responses-to-death-related-imagery
#20
Naomi I Gribneau Bahm, Emiliana R Simon-Thomas, Mary Main, Erik Hesse
This study investigates whether individual differences in attachment status can be detected by electrophysiological responses to loss-themed pictures. The Adult Attachment Interview (AAI) was used to identify discourse/reasoning lapses during the discussion of loss experiences via death that place speakers in the Unresolved/disorganized AAI category. In parents, Unresolved AAI status has been associated with Disorganized infant Strange Situation response, a known risk factor for psychopathology (e.g., internalizing/externalizing/dissociation)...
January 2017: Developmental Psychology
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