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https://www.readbyqxmd.com/read/28545255/frozen-accident-pushing-50-stereochemistry-expansion-and-chance-in-the-evolution-of-the-genetic-code
#1
Eugene V Koonin
Nearly 50 years ago, Francis Crick propounded the frozen accident scenario for the evolution of the genetic code along with the hypothesis that the early translation system consisted primarily of RNA. Under the frozen accident perspective, the code is universal among modern life forms because any change in codon assignment would be highly deleterious. The frozen accident can be considered the default theory of code evolution because it does not imply any specific interactions between amino acids and the cognate codons or anticodons, or any particular properties of the code...
May 23, 2017: Life
https://www.readbyqxmd.com/read/28545227/potential-use-of-chemoprotectants-against-the-toxic-effects-of-cyanotoxins-a-review
#2
REVIEW
Remedios Guzmán-Guillén, María Puerto, Daniel Gutiérrez-Praena, Ana I Prieto, Silvia Pichardo, Ángeles Jos, Alexandre Campos, Vitor Vasconcelos, Ana M Cameán
Cyanobacterial toxins, particularly microcystins (MCs) and cylindrospermopsin (CYN), are responsible for toxic effects in humans and wildlife. In order to counteract or prevent their toxicity, various strategies have been followed, such as the potential application of chemoprotectants. A review of the main substances evaluated for this aim, as well as the doses and their influence on cyanotoxin-induced toxicity, has been performed. A search of the literature shows that research on MCs is much more abundant than research on CYN...
May 23, 2017: Toxins
https://www.readbyqxmd.com/read/28545218/temporal-variability-in-taxonomic-and-trait-compositions-of-invertebrate-assemblages-in-two-climatic-regions-with-contrasting-flow-regimes
#3
Sylvain Dolédec, Jessica Tilbian, Núria Bonada
CONTEXT: Understanding natural temporal changes in Mediterranean rivers with contrasting flow regimes in relation to those of temperate rivers may prove helpful in predicting effects of climate change on aquatic biodiversity. GOAL: We aimed to compare temporal variability in taxonomic and trait compositions of nearly natural rivers in two climatic regions with varying flow regimes to address the effects of future climate changes on aquatic biodiversity in reference conditions...
May 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28544927/estuarine-sediment-resuspension-and-acidification-release-behaviour-of-contaminants-under-different-oxidation-levels-and-acid-sources
#4
M Camino Martín-Torre, Eva Cifrian, Gema Ruiz, Berta Galán, Javier R Viguri
Carbon dioxide (CO2) Capture and Storage (CCS) is a technology to reduce the emissions of this gas to the atmosphere by sequestering it in geological formations. In the case of offshore storage, unexpected CO2 leakages will acidify the marine environment. Reductions of the pH might be also caused by anthropogenic activities or natural events such as acid spills and dredging operations or storms and floods. Changes in the pH of the marine environment will trigger the mobilisation of elements trapped in contaminated shallow sediments with unclear redox boundary...
May 22, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28544926/understanding-the-influence-of-power-and-empathic-perspective-taking-on-collaborative-natural-resource-management
#5
Dara M Wald, Elizabeth A Segal, Erik W Johnston, Ajay Vinze
Public engagement in collaborative natural resource management necessitates shared understanding and collaboration. Empathic perspective-taking is a critical facilitator of shared understanding and positive social interactions, such as collaboration. Yet there is currently little understanding about how to reliably generate empathic perspective-taking and collaboration, particularly in situations involving the unequal distribution of environmental resources or power. Here we examine how experiencing the loss or gain of social power influenced empathic perspective-taking and behavior within a computer-mediated scenario...
May 22, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28544857/new-treatment-directions-for-ipf-current-status-of-ongoing-and-upcoming-clinical-trials
#6
Francesco Macagno, Francesco Varone, Paolo Maria Leone, Pier-Valerio Mari, Loredana Panico, Ludovica Berardini, Luca Richeldi
The main objective of this review is to explore the wide and expanding field of new clinical trials in IPF. Recent trials have confirmed the efficacy of the approved drugs pirfenidone and nintedanib; nonetheless, the discovery of new biological pathways has opened new horizons in this field. Areas Covered: New strategies against matrix deposition are under study and so is for the role of immunity and autoimmunity. Recent advances in the use of stem cells are opening new possibilities for the recovery of damaged lung tissues...
May 25, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28544805/a-comparison-of-attitudes-to-laryngeal-cancer-treatment-outcomes-a-time-trade-off-study
#7
David W Hamilton, Ami Pedersen, Hannah Blanchford, Janneke E Bins, Peter McMeekin, Richard Thomson, Vinidh Paleri, Janet A Wilson
DESIGN: Time trade-off choice experiment. SETTING: Two large head and neck cancer centres. PARTICIPANTS: Patients who have received treatment for head and neck cancer and members of the head and neck cancer multidisciplinary team. MAIN OUTCOME MEASURES: Participants were asked to rank the outcome scenarios, assign utility values using time trade-off and rate the importance of survival on treatment choice. RESULTS: 49 head and neck cancer patients and 73 staff members were recruited...
May 19, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28544662/tracheal-replacement-therapy-with-a-stem-cell-seeded-graft-lessons-from-compassionate-use-application-of-a-gmp-compliant-tissue-engineered-medicine
#8
Martin J Elliott, Colin R Butler, Aikaterini Varanou-Jenkins, Leanne Partington, Carla Carvalho, Edward Samuel, Claire Crowley, Peggy Lange, Nicholas J Hamilton, Robert E Hynds, Tahera Ansari, Paul Sibbons, Anja Fierens, Claire McLaren, Derek Roebuck, Colin Wallis, Nagarajan Muthialu, Richard Hewitt, David Crabbe, Sam M Janes, Paolo De Coppi, Mark W Lowdell, Martin A Birchall
Tracheal replacement for the treatment of end-stage airway disease remains an elusive goal. The use of tissue-engineered tracheae in compassionate use cases suggests that such an approach is a viable option. Here, a stem cell-seeded, decellularized tissue-engineered tracheal graft was used on a compassionate basis for a girl with critical tracheal stenosis after conventional reconstructive techniques failed. The graft represents the first cell-seeded tracheal graft manufactured to full good manufacturing practice (GMP) standards...
June 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28544622/an-investigation-into-the-two-stage-meta-analytic-copula-modelling-approach-for-evaluating-time-to-event-surrogate-endpoints-which-comprise-of-one-or-more-events-of-interest
#9
Natalie Dimier, Susan Todd
Clinical trials of experimental treatments must be designed with primary endpoints that directly measure clinical benefit for patients. In many disease areas, the recognised gold standard primary endpoint can take many years to mature, leading to challenges in the conduct and quality of clinical studies. There is increasing interest in using shorter-term surrogate endpoints as substitutes for costly long-term clinical trial endpoints; such surrogates need to be selected according to biological plausibility, as well as the ability to reliably predict the unobserved treatment effect on the long-term endpoint...
May 19, 2017: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/28544361/drug-coated-balloons-for-the-treatment-of-in-stent-restenosis-in-diabetic-patients-a-review-of-currently-available-scientific-data
#10
Alberto Minacapelli, Davide Piraino, Dario Buccheri, Bernardo Cortese
After the introduction of drug eluting stent (DES) the rate of in-stent restenosis (ISR) has decreased if compared to the BMS era; however, treatment of patients with ISR remained a major issue for the interventional cardiologist. DES has been largely used with good results also as second layer for the treatment of ISR, but the overall percentage of patients suffering from restenosis still remains high, especially in some subgroups of patients as ones with diabetes mellitus (DM). In this clinical scenario, drug coated balloon (DCB) has been gaining an important role for the treatment of ISR...
May 22, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28544319/selected-copper-based-reactions-for-c-n-c-o-c-s-and-c-c-bond-formation
#11
Dawei Ma, Subhajit Bhunia, Govind Goroba Pawar, S Vijay Kumar, Yongwen Jiang
The metal catalyzed cross-coupling reactions are one of the most important transformations in organic synthesis. Copper catalysis has received great attention due to its low toxicity and inexpensive nature. However, traditional Ullmann-type coupling reactions suffered from limited substrate scope and harsh reaction conditions. The introduction of some bidentate ligands such as amino acids, diamines, 1,3-diketones and oxalic diamides during the past two decades has totally changed its scenario, allowing the coupling reactions of aryl halides and nucleophiles to take place at both low reaction temperatures and catalytic loadings...
May 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28544184/did-some-red-alga-derived-plastids-evolve-via-kleptoplastidy-a-hypothesis
#12
Andrzej Bodył
The evolution of plastids has a complex and still unresolved history. These organelles originated from a cyanobacterium via primary endosymbiosis, resulting in three eukaryotic lineages: glaucophytes, red algae, and green plants. The red and green algal plastids then spread via eukaryote-eukaryote endosymbioses, known as secondary and tertiary symbioses, to numerous heterotrophic protist lineages. The number of these horizontal plastid transfers, especially in the case of red alga-derived plastids, remains controversial...
May 23, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28544181/the-k-2-conundrum
#13
Jasmine K Janes, Joshua M Miller, Julian R Dupuis, René M Malenfant, Jamieson C Gorrell, Catherine I Cullingham, Rose L Andrew
Assessments of population genetic structure have become an increasing focus as they can provide valuable insight into patterns of migration and gene flow. STRUCTURE, the most highly cited of several clustering-based methods, was developed to provide robust estimates without the need for populations to be determined a priori. STRUCTURE introduces the problem of selecting the optimal number of clusters and as a result the ΔK method was proposed to assist in the identification of the 'true' number of clusters...
May 21, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28544070/the-importance-of-assessing-out-of-pocket-payments-when-the-financing-of-antiretroviral-therapy-is-transitioned-to-domestic-funding-findings-from-vietnam
#14
Benjamin Johns, Le Bao Chau, Kieu Huu Hanh, Nguyen Thuy Huong, Hoa Mai Do, Anh Thuy Duong, Long Hoang Nguyen
OBJECTIVE: To assess out-of-pocket payments and catastrophic health expenditures among antiretroviral therapy (ART) patients in Vietnam, and to model catastrophic payments under different copayment scenarios when the primary financing of ART changes to social health insurance. METHODS: Cross-sectional facility-based survey of 843 patients at 42 health facilities representative of 87% of ART patients in 2015. RESULTS: Because of donor and government funding, no payments were made for antiretroviral drugs...
May 19, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28543951/determination-of-genetic-relatedness-from-low-coverage-human-genome-sequences-using-pedigree-simulations
#15
Michael D Martin, Flora Jay, Sergi Castellano, Montgomery Slatkin
We develop and evaluate methods for inferring relatedness among individuals from low-coverage DNA sequences of their genomes, with particular emphasis on sequences obtained from fossil remains. We suggest the major factors complicating the determination of relatedness among ancient individuals are sequencing depth, the number of overlapping sites, the sequencing error rate, and the presence of contamination from present-day genetic sources. We develop a theoretical model that facilitates the exploration of these factors and their relative effects, via measurement of pairwise genetic distances, without calling genotypes, and determine the power to infer relatedness under various scenarios of varying sequencing depth, present-day contamination, and sequencing error...
May 25, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28543449/the-ascending-projections-of-the-nuclei-of-the-descending-trigeminal-tract-nttd-in-the-zebra-finch-taeniopygia-guttata
#16
Macarena Faunes, J Martin Wild
In our traditional view of the avian somatosensory system, input from the beak and head reaches the telencephalon via a disynaptic pathway, involving projections from the principal sensory nucleus (PrV) directly to nucleus basorostralis (previously called nucleus basalis), whereas input from the rest of the body follows a trisynatic pathway similar to that in mammals, involving projections from the dorsal column nuclei to the thalamus, and thence to somatosensory cortex. However, the role of the nuclei of the descending trigeminal tract (nTTD) in this scenario is unclear, partly because their ascending projections have been examined in only one species, the mallard duck (Arends & Dubbeldam, 1984, Neuroscience 13(3):797-817)...
May 23, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28543228/scenario-evaluator-for-electrical-resistivity-survey-pre-modeling-tool
#17
Neil Terry, Frederick D Day-Lewis, Judith L Robinson, Lee D Slater, Keith Halford, Andrew Binley, John W Lane, Dale Werkema
Geophysical tools have much to offer users in environmental, water resource, and geotechnical fields; however, techniques such as electrical resistivity imaging (ERI) are often oversold and/or overinterpreted due to a lack of understanding of the limitations of the techniques, such as the appropriate depth intervals or resolution of the methods. The relationship between ERI data and resistivity is nonlinear; therefore, these limitations depend on site conditions and survey design and are best assessed through forward and inverse modeling exercises prior to field investigations...
May 23, 2017: Ground Water
https://www.readbyqxmd.com/read/28543218/the-time-course-of-indirect-moral-judgment-in-gossip-processing-modulated-by-different-agents
#18
Xiaozhe Peng, Can Jiao, Fang Cui, Qingfei Chen, Peng Li, Hong Li
Previous studies have investigated personal moral violations with different references (i.e., the protagonists in moral scenarios are the participants themselves or unknown other individuals). However, the roles of various agents in moral judgments have remained unclear. In the present study, ERPs were used to investigate moral judgments when the participants viewed gossip that described (im)moral behaviors committed by different agents (self, friend, celebrity). The results demonstrate that the P2 and late positive component (LPC) correspond to two successive processes of indirect moral judgment when individuals process gossip...
May 24, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28542636/influence-of-learning-styles-on-the-practical-performance-after-the-four-step-basic-life-support-training-approach-an-observational-cohort-study
#19
Hanna Schröder, Alexandra Henke, Lina Stieger, Stefan Beckers, Henning Biermann, Rolf Rossaint, Saša Sopka
BACKGROUND: Learning and training basic life support (BLS)-especially external chest compressions (ECC) within the BLS-algorithm-are essential resuscitation training for laypersons as well as for health care professionals. The objective of this study was to evaluate the influence of learning styles on the performance of BLS and to identify whether all types of learners are sufficiently addressed by Peyton's four-step approach for BLS training. METHODS: A study group of first-year medical students (n = 334) without previous medical knowledge was categorized according to learning styles using the German Lernstilinventar questionnaire based on Kolb's Learning Styles Inventory...
2017: PloS One
https://www.readbyqxmd.com/read/28542580/endovascular-stentectomy-using-the-snare-over-stent-retriever-sos-technique-an-experimental-feasibility-study
#20
Tareq Meyer, Omid Nikoubashman, Lisa Kabelitz, Marguerite Müller, Ahmed Othman, Saif Afat, Martin Kramer, Martin Wiesmann, Marc A Brockmann, Carolin Brockmann
Feasibility of endovascular stentectomy using a snare over stent-retriever (SOS) technique was evaluated in a silicon flow model and an in vivo swine model. In vitro, stentectomy of different intracranial stents using the SOS technique was feasible in 22 out of 24 (92%) retrieval maneuvers. In vivo, stentectomy was successful in 10 out of 10 procedures (100%). In one case self-limiting vasospasm was observed angiographically as a technique related complication in the animal model. Endovascular stentectomy using the SOS technique is feasible in an experimental setting and may be transferred to a clinical scenario...
2017: PloS One
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