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https://www.readbyqxmd.com/read/28642641/inequality-in-human-capital-and-endogenous-credit-constraints
#1
Rong Hai, James J Heckman
This paper investigates the determinants of inequality in human capital with an emphasis on the role of the credit constraints. We develop and estimate a model in which individuals face uninsured human capital risks and invest in education, acquire work experience, accumulate assets and smooth consumption. Agents can borrow from the private lending market and from government student loan programs. The private market credit limit is explicitly derived by extending the natural borrowing limit of Aiyagari (1994) to incorporate endogenous labor supply, human capital accumulation, psychic costs of working, and age...
April 2017: Review of Economic Dynamics
https://www.readbyqxmd.com/read/28616801/life-course-perspectives-on-the-onset-and-continuity-of-preventive-healthcare-behaviors
#2
REVIEW
Preecha Yingwattanakul, George P Moschis
Preventive healthcare is considered a cornerstone of good health and well-being that can play a major role in reducing a country's healthcare costs and improving both the length and quality of people's lives. Previous research on preventive healthcare behaviors has been predominantly cross-sectional, ignoring the dynamic nature of people's health behaviors over a full life span. As a result, the reasons for the development, stability, and changes of individuals' preventive healthcare behaviors over time remain relatively unknown...
June 14, 2017: Journal of Primary Prevention
https://www.readbyqxmd.com/read/28614394/first-report-of-naturally-infected-aedes-aegypti-with-chikungunya-virus-genotype-ecsa-in-the-americas
#3
André Luis Costa-da-Silva, Rafaella Sayuri Ioshino, Vivian Petersen, Antonio Fernando Lima, Marielton Dos Passos Cunha, Michael R Wiley, Jason T Ladner, Karla Prieto, Gustavo Palacios, Danuza Duarte Costa, Lincoln Suesdek, Paolo Marinho de Andrade Zanotto, Margareth Lara Capurro
BACKGROUND: The worldwide expansion of new emergent arboviruses such as Chikungunya and Zika reinforces the importance in understanding the role of mosquito species in spreading these pathogens in affected regions. This knowledge is essential for developing effective programs based on species specificity to avoid the establishment of endemic transmission cycles sustained by the identified local vectors. Although the first autochthonous transmission of Chikungunya virus was described in 2014 in the north of Brazil, the main outbreaks were reported in 2015 and 2016 in the northeast of Brazil...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28606131/improving-primary-health-care-facility-performance-in-ghana-efficiency-analysis-and-fiscal-space-implications
#4
Jacob Novignon, Justice Nonvignon
BACKGROUND: Health centers in Ghana play an important role in health care delivery especially in deprived communities. They usually serve as the first line of service and meet basic health care needs. Unfortunately, these facilities are faced with inadequate resources. While health policy makers seek to increase resources committed to primary healthcare, it is important to understand the nature of inefficiencies that exist in these facilities. Therefore, the objectives of this study are threefold; (i) estimate efficiency among primary health facilities (health centers), (ii) examine the potential fiscal space from improved efficiency and (iii) investigate the efficiency disparities in public and private facilities...
June 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28603836/rates-characteristics-and-circumstances-of-methamphetamine-related-death-in-australia-a-national-7-year-study
#5
Shane Darke, Sharlene Kaye, Johan Duflou
AIMS: Assess trends in the number, and mortality rates, of methamphetamine-related death in Australia, 2009-2015; 2. Assess the characteristics, and the cause, manner and circumstances of death; and 3. Assess the blood methamphetamine concentrations and the presence of other drugs in methamphetamine-related death. DESIGN: Analysis of cases of methamphetamine-related death retrieved from the National Coronial Information System (NCIS). SETTING: Australia...
June 11, 2017: Addiction
https://www.readbyqxmd.com/read/28599360/lessons-learned-from-khartoum-flash-flood-impacts-an-integrated-assessment
#6
Mohamad Ibrahim Mahmood, Nadir Ahmed Elagib, Finlay Horn, Suhair A G Saad
This study aims at enabling the compilation of key lessons for decision makers and urban planners in rapidly urbanizing cities regarding the identification of representative, chief causal natural and human factors for the increased level of flash flood risk. To achieve this, the impacts of flash flood events of 2013 and 2014 in the capital of Sudan, Khartoum, were assessed using seven integrated approaches, i.e. rainfall data analysis, document analysis of affected people and houses, observational fieldwork in the worst flood affected areas, people's perception of causes and mitigation measures through household interviews, reported drinking water quality, reported water-related diseases and social risk assessment...
June 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28598711/twelve-tips-for-just-in-time-teaching-of-communication-skills-for-difficult-conversations-in-the-clinical-setting
#7
Laura Jean Hinkle, Lyle Patrick Fettig, William Graham Carlos, Gabriel Bosslet
The ability to communicate well with patients and other members of the healthcare team is a vital skill for physicians to have, but one that is often not emphasized in medical education. Learners of all levels can obtain and develop good communication skills regardless of their natural ability in this area, and the clinical setting represents an underutilized resource to accomplish this task. With this in mind, we have reviewed the growing body of literature on the subject and organized our findings into twelve tips to help educators capitalize on these missed opportunities...
June 9, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28589278/hydrologic-monitoring-tools-for-freshwater-municipal-planning-in-the-arctic-the-case-of-iqaluit-nunavut-canada
#8
Michael Bakaic, Andrew Scott Medeiros, Jessica F Peters, Brent B Wolfe
Freshwater and the services it provides are vital to both natural ecosystems and human needs; however, extreme climates and their influence on freshwater availability can be challenging for municipal planners and engineers to manage these resources effectively. In Arctic Canada, financial and human capital limitations have left a legacy of freshwater systems that underserve current communities and may be inadequate in the near future under a warming climate, growing population, and increasing demand. We address this challenge to community water resource planning by applying several novel water supply forecasting methods to evaluate the Apex River as an alternative freshwater source for Iqaluit, Nunavut (Canada)...
June 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28588145/ecosystem-based-management-and-the-wealth-of-ecosystems
#9
Seong Do Yun, Barbara Hutniczak, Joshua K Abbott, Eli P Fenichel
We merge inclusive wealth theory with ecosystem-based management (EBM) to address two challenges in the science of sustainable management of ecosystems. First, we generalize natural capital theory to approximate realized shadow prices for multiple interacting natural capital stocks (species) making up an ecosystem. These prices enable ecosystem components to be better included in wealth-based sustainability measures. We show that ecosystems are best envisioned as portfolios of assets, where the portfolio's performance depends on the performance of the underlying assets influenced by their interactions...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28587134/measuring-blue-space-visibility-and-blue-recreation-in-the-everyday-lives-of-children-in-a-capital-city
#10
Amber L Pearson, Ross Bottomley, Tim Chambers, Lukar Thornton, James Stanley, Moira Smith, Michelle Barr, Louise Signal
Blue spaces (water bodies) may promote positive mental and physical health through opportunities for relaxation, recreation, and social connections. However, we know little about the nature and extent of everyday exposure to blue spaces, particularly in settings outside the home or among children, nor whether exposure varies by individual or household characteristics. Wearable cameras offer a novel, reliable method for blue space exposure measurement. In this study, we used images from cameras worn over two days by 166 children in Wellington, New Zealand, and conducted content and blue space quantification analysis on each image (n = 749,389)...
May 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28579736/human-capital-growth-and-poverty-evidence-from-ethiopia-and-peru
#11
Orazio Attanasio, Costas Meghir, Emily Nix, Francesca Salvati
In this paper we use high quality data from two developing countries, Ethiopia and Peru, to estimate the production functions of human capital from age 1 to age 15. We characterize the nature of persistence and dynamic complementarities between two components of human capital: health and cognition. We also explore the implications of different functional form assumptions for the production functions. We find that more able and higher income parents invest more, particularly at younger ages when investments have the greatest impacts...
April 2017: Review of Economic Dynamics
https://www.readbyqxmd.com/read/28577697/economic-impacts-of-the-generic-drug-user-fee-act-fee-structure
#12
Ke Dong, Garth Boehm, Qiang Zheng
BACKGROUND: A Food and Drug Administration (FDA) Generic Drug User system, Generic Drug User Fee Amendment of 2012 (GDUFA), started October 1, 2012, and has been in place for over 3 years. There is controversy about the GDUFA fee structure but no analysis of GDUFA data that we could find. OBJECTIVE: To look at the economic impact of the GDUFA fee structure. METHODS: We compared the structure of GDUFA with that of other FDA Human Drug User fees...
June 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28570056/intensity-independent-noise-filtering-in-ft-ms-and-ft-ms-ms-spectra-for-shotgun-lipidomics
#13
Kai Schuhmann, Henrik Thomas, Jacobo Miranda Ackerman, Konstantin O Nagornov, Yury O Tsybin, Andrej Shevchenko
Shotgun lipidomics relies on the direct infusion of total lipid extracts into a high resolution tandem mass spectrometer. A single shotgun analysis produces several hundred of densely populated FT MS and FT MS/MS spectra, each of which might comprise thousands of peaks although a very small percentage of those belong to lipids. Eliminating noise by adjusting a minimal peak intensity threshold is biased and inefficient since lipid species and classes vary in their natural abundance and ionization capacity. We developed a method of peak intensity-independent noise filtering in shotgun FT MS and FT MS/MS spectra that capitalizes on a stable composition of the infused analyte leading to consistent time-independent detection of its bona fide components...
June 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28558634/differential-regulation-of-cyp3a4-and-cyp3a5-and-its-implication-in-drug-discovery
#14
Ogheneochukome Lolodi, Yue-Ming Wang, William C Wright, Taosheng Chen
Cancer cells use several mechanisms to resist the cytotoxic effects of drugs, resulting in tumor progression and invasion. One such mechanism capitalizes on the body's natural defense against xenobiotics. Recent reports indicate that components of the xenobiotic response system are upregulated in some diseases, including many cancers. Such components include the pregnane X receptor and the cytochrome P450 3A4 and 3A5 enzymes. Intense research is ongoing to understand the functional ramifications of aberrant expression of these components in diseased states with the goal of designing novel drugs that can selectively target them...
May 30, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28555353/information-and-communications-technologies-health-projects-in-panama-a-systematic-review-and-their-relation-with-public-policies
#15
Gema Anabel Castillo Sánchez, Aranzazu Berbey, Isabel de la Torre-Díez, Miguel López-Coronado
This paper presents a review about Information and Communications Technologies (ICTs) health projects in Panama. The main contribution is to provide a vision of the situation in Panama, allowing an understanding of the dynamics of health policies and how they have affected the implementation of ICT's Projects to improve the health of Panamanians. We analyze the projects found with ICT's in health of Panama, which allow us to see a perspective of projects information is obtained from 2000 to 2016, however it is important to highlight that there may be other projects that we do not know because we did not find enough information or evidence of the same...
July 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28550625/make-it-real-belief-in-occurrence-within-episodic-future-thought
#16
Alexandra Ernst, Arnaud D'Argembeau
While the cognitive and neural bases of episodic future thinking are well documented, questions remain as to what gives the sense that an imagined event belongs to one's personal future. Capitalizing on previous research on metacognitive appraisals in autobiographical remembering, we propose that episodic future thinking involves, in varying degrees, a subjective belief in the potential occurrence of imagined future events and we explore the nature and determinants of such belief. To this aim, participants provided justifications for belief in occurrence for a series of past and future events...
May 26, 2017: Memory & Cognition
https://www.readbyqxmd.com/read/28513428/slipped-capital-femoral-epiphysis-a-review-of-management-in-the-hip-impingement-era
#17
Mahmoud A Mahran, Mostafa M Baraka, Hany M Hefny
Slipped capital femoral epiphysis (SCFE) remains the most common adolescent hip disorder. Most cases present with stable slips, and in situ fixation is the most commonly adopted treatment worldwide. The introduction of the concept of femoroacetabular impingement and subsequent studies have revealed SCFE-related hip impingement to be a significant pre-arthritic condition, and the previously suggested remodeling of the proximal femur after in situ fixation has been called into question. Complex proximal femoral osteotomies and more recently intra-articular procedures via surgical hip dislocation have been employed...
2017: SICOT-J
https://www.readbyqxmd.com/read/28508047/kin-based-cultural-transmission-of-tool-use-in-wild-chimpanzees
#18
Noemie Lamon, Christof Neumann, Thibaud Gruber, Klaus Zuberbühler
Current research on animal culture has focused strongly on cataloging the diversity of socially transmitted behaviors and on the social learning mechanisms that sustain their spread. Comparably less is known about the persistence of cultural behavior following innovation in groups of wild animals. We present observational data and a field experiment designed to address this question in a wild chimpanzee community, capitalizing on a novel tool behavior, moss-sponging, which appeared naturally in the community in 2011...
April 2017: Science Advances
https://www.readbyqxmd.com/read/28502014/inventions-and-patents-a-practical-tutorial
#19
Hina Mehta, Lille Tidwell, Lance A Liotta
Patents are designed to protect and encourage creativity and innovation. Patenting a biomedical discovery can be a requirement before a pharmaceutical company or biotech entity will invest in the lengthy and capital-intensive drug development and clinical trials necessary to achieve patient benefit. Although scientists and clinicians are well versed in research publication requirements, patent descriptions and claims are formatted in a manner quite different from a research paper. Patents require (a) a series of logical statements clearly delineating the boundaries of the novel aspects of the invention and (b) sufficient disclosure of the invention so that it can be reproduced by others...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28497798/phosphorylation-induces-sequence-specific-conformational-switches-in-the-rna-polymerase-ii-c-terminal-domain
#20
Eric B Gibbs, Feiyue Lu, Bede Portz, Michael J Fisher, Brenda P Medellin, Tatiana N Laremore, Yan Jessie Zhang, David S Gilmour, Scott A Showalter
The carboxy-terminal domain (CTD) of the RNA polymerase II (Pol II) large subunit cycles through phosphorylation states that correlate with progression through the transcription cycle and regulate nascent mRNA processing. Structural analyses of yeast and mammalian CTD are hampered by their repetitive sequences. Here we identify a region of the Drosophila melanogaster CTD that is essential for Pol II function in vivo and capitalize on natural sequence variations within it to facilitate structural analysis. Mass spectrometry and NMR spectroscopy reveal that hyper-Ser5 phosphorylation transforms the local structure of this region via proline isomerization...
May 12, 2017: Nature Communications
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